ZNF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.77835677
2piRNA metabolic process (GO:0034587)4.64294709
3DNA deamination (GO:0045006)4.46089406
4DNA methylation involved in gamete generation (GO:0043046)4.10731055
5negative regulation of telomere maintenance (GO:0032205)4.08872499
6fucose catabolic process (GO:0019317)3.98145694
7L-fucose metabolic process (GO:0042354)3.98145694
8L-fucose catabolic process (GO:0042355)3.98145694
9kynurenine metabolic process (GO:0070189)3.82300615
10preassembly of GPI anchor in ER membrane (GO:0016254)3.77220096
11tryptophan catabolic process (GO:0006569)3.74054792
12indole-containing compound catabolic process (GO:0042436)3.74054792
13indolalkylamine catabolic process (GO:0046218)3.74054792
14meiotic chromosome segregation (GO:0045132)3.74040026
15response to pheromone (GO:0019236)3.72275872
16regulation of nuclear cell cycle DNA replication (GO:0033262)3.65414337
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63912292
18detection of light stimulus involved in sensory perception (GO:0050962)3.52970305
19detection of light stimulus involved in visual perception (GO:0050908)3.52970305
20indolalkylamine metabolic process (GO:0006586)3.50068151
21protein complex biogenesis (GO:0070271)3.40606198
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40159427
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.40159427
24NADH dehydrogenase complex assembly (GO:0010257)3.40159427
25reciprocal DNA recombination (GO:0035825)3.38761435
26reciprocal meiotic recombination (GO:0007131)3.38761435
27regulation of telomere maintenance (GO:0032204)3.33219641
28mannosylation (GO:0097502)3.28596478
29L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27672956
30respiratory chain complex IV assembly (GO:0008535)3.27261603
31water-soluble vitamin biosynthetic process (GO:0042364)3.24595279
32mitochondrial respiratory chain complex assembly (GO:0033108)3.21255754
33tryptophan metabolic process (GO:0006568)3.15201681
34male meiosis I (GO:0007141)3.12013327
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09647905
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09647905
37recombinational repair (GO:0000725)3.09377336
38double-strand break repair via homologous recombination (GO:0000724)3.09229381
39sulfation (GO:0051923)3.07277301
40epithelial cilium movement (GO:0003351)3.06567318
41replication fork processing (GO:0031297)3.06353960
42male meiosis (GO:0007140)3.05963376
43regulation of hippo signaling (GO:0035330)3.02204681
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01139689
45cytochrome complex assembly (GO:0017004)3.00399043
46cornea development in camera-type eye (GO:0061303)3.00028111
47negative regulation of mast cell activation (GO:0033004)2.97794999
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96639362
49neural tube formation (GO:0001841)2.92228361
50regulation of meiosis I (GO:0060631)2.90837410
51rRNA catabolic process (GO:0016075)2.87177674
52negative regulation of DNA-dependent DNA replication (GO:2000104)2.86863160
53axoneme assembly (GO:0035082)2.85585354
54synapsis (GO:0007129)2.85075225
55pseudouridine synthesis (GO:0001522)2.84544427
56photoreceptor cell maintenance (GO:0045494)2.84078239
57protein K11-linked deubiquitination (GO:0035871)2.83836664
58regulation of mitotic spindle checkpoint (GO:1903504)2.83143121
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83143121
60cellular ketone body metabolic process (GO:0046950)2.83010834
61protein-cofactor linkage (GO:0018065)2.80915898
62ubiquinone biosynthetic process (GO:0006744)2.80042298
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.79067692
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79067692
65regulation of translation, ncRNA-mediated (GO:0045974)2.78668705
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78668705
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.78668705
68L-methionine salvage (GO:0071267)2.76850410
69L-methionine biosynthetic process (GO:0071265)2.76850410
70amino acid salvage (GO:0043102)2.76850410
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73292362
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69172586
73cellular response to ATP (GO:0071318)2.68859997
74protein polyglutamylation (GO:0018095)2.67719413
75cellular response to exogenous dsRNA (GO:0071360)2.65841915
76behavioral response to ethanol (GO:0048149)2.64770285
77regulation of cilium movement (GO:0003352)2.64528970
78protein K6-linked ubiquitination (GO:0085020)2.61614785
79centriole replication (GO:0007099)2.61421286
80platelet dense granule organization (GO:0060155)2.60787048
81GPI anchor metabolic process (GO:0006505)2.60103715
82cilium morphogenesis (GO:0060271)2.59632612
83endoderm formation (GO:0001706)2.59133804
84ubiquinone metabolic process (GO:0006743)2.58834608
85methionine biosynthetic process (GO:0009086)2.57743946
86ketone body metabolic process (GO:1902224)2.56754175
87peptidyl-histidine modification (GO:0018202)2.55744261
88positive regulation of mitochondrial fission (GO:0090141)2.55425504
89oxidative demethylation (GO:0070989)2.55261840
90tRNA processing (GO:0008033)2.53997700
91positive regulation of defense response to virus by host (GO:0002230)2.53604337
92aromatic amino acid family catabolic process (GO:0009074)2.50067752
93indole-containing compound metabolic process (GO:0042430)2.49897835
94negative regulation of reactive oxygen species metabolic process (GO:2000378)2.49343380
95tRNA modification (GO:0006400)2.47259061
96cilium or flagellum-dependent cell motility (GO:0001539)2.47176968
97C-terminal protein lipidation (GO:0006501)2.46836551
98prenylation (GO:0097354)2.44446553
99protein prenylation (GO:0018342)2.44446553
100nephron tubule morphogenesis (GO:0072078)2.43533621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.45471339
2VDR_22108803_ChIP-Seq_LS180_Human3.04932079
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04007122
4IGF1R_20145208_ChIP-Seq_DFB_Human3.01867405
5GBX2_23144817_ChIP-Seq_PC3_Human2.79803050
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63075016
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51921975
8EWS_26573619_Chip-Seq_HEK293_Human2.48905997
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.43354730
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38861987
11* GABP_17652178_ChIP-ChIP_JURKAT_Human2.37530970
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35353736
13FUS_26573619_Chip-Seq_HEK293_Human2.34050474
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28001609
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27994106
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.24004730
17ER_23166858_ChIP-Seq_MCF-7_Human2.05385621
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98424475
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.97826966
20EZH2_22144423_ChIP-Seq_EOC_Human1.96691204
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.92628681
22TAF15_26573619_Chip-Seq_HEK293_Human1.87983808
23P300_19829295_ChIP-Seq_ESCs_Human1.85976218
24* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85948315
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85434629
26TP53_22573176_ChIP-Seq_HFKS_Human1.76469078
27* VDR_23849224_ChIP-Seq_CD4+_Human1.75032544
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74888857
29IRF1_19129219_ChIP-ChIP_H3396_Human1.74798171
30MYC_18940864_ChIP-ChIP_HL60_Human1.74062933
31ELK1_19687146_ChIP-ChIP_HELA_Human1.58041765
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55586122
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55320298
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53564042
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53437387
36CBP_20019798_ChIP-Seq_JUKART_Human1.53437387
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.51598467
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49984369
39STAT3_23295773_ChIP-Seq_U87_Human1.48437438
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46704939
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45736850
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41065209
43BCAT_22108803_ChIP-Seq_LS180_Human1.41012092
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39385980
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35859478
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35640828
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35409179
48HOXB7_26014856_ChIP-Seq_BT474_Human1.35406639
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33850896
50TCF4_23295773_ChIP-Seq_U87_Human1.33108647
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32954790
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.32954790
53AR_25329375_ChIP-Seq_VCAP_Human1.29268430
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28217015
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27886016
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.26293601
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.26177217
58SOX2_19829295_ChIP-Seq_ESCs_Human1.25706004
59NANOG_19829295_ChIP-Seq_ESCs_Human1.25706004
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.25032024
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.23867222
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20762827
63TCF4_22108803_ChIP-Seq_LS180_Human1.20652075
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20447447
65SMAD4_21799915_ChIP-Seq_A2780_Human1.20170346
66AR_20517297_ChIP-Seq_VCAP_Human1.19273752
67NCOR_22424771_ChIP-Seq_293T_Human1.19069203
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18147212
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17416376
70FOXP3_21729870_ChIP-Seq_TREG_Human1.15536937
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14135008
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14135008
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13740138
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12780287
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12621924
76AR_21572438_ChIP-Seq_LNCaP_Human1.11107319
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10712791
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10631246
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10061018
80RUNX2_22187159_ChIP-Seq_PCA_Human1.09074061
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.07409810
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.07199077
83ERA_21632823_ChIP-Seq_H3396_Human1.07131389
84RNF2_27304074_Chip-Seq_NSC_Mouse1.07048539
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03719344
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01174092
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00555727
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.00362504
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99942916
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99734782
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.99388588
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98569739
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98525359
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98399354
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.97391505
96CBX2_27304074_Chip-Seq_ESCs_Mouse0.96639128
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96147929
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.95958914
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95766249
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94354101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.04460227
2MP0008877_abnormal_DNA_methylation2.92794713
3MP0003136_yellow_coat_color2.84095149
4MP0003195_calcinosis2.81691333
5MP0002837_dystrophic_cardiac_calcinosis2.76386608
6MP0005551_abnormal_eye_electrophysiolog2.53478167
7MP0004043_abnormal_pH_regulation2.43918013
8MP0008058_abnormal_DNA_repair2.32008857
9MP0002102_abnormal_ear_morphology2.18999462
10MP0000372_irregular_coat_pigmentation2.12777695
11MP0006072_abnormal_retinal_apoptosis2.07378550
12MP0000569_abnormal_digit_pigmentation1.98317525
13MP0002928_abnormal_bile_duct1.97424406
14MP0004133_heterotaxia1.95535844
15MP0000427_abnormal_hair_cycle1.94592319
16MP0008872_abnormal_physiological_respon1.89135633
17MP0005253_abnormal_eye_physiology1.88109881
18MP0001968_abnormal_touch/_nociception1.84448088
19MP0005646_abnormal_pituitary_gland1.83875333
20MP0002138_abnormal_hepatobiliary_system1.83613496
21MP0002653_abnormal_ependyma_morphology1.78588102
22MP0004142_abnormal_muscle_tone1.76992715
23MP0004147_increased_porphyrin_level1.72600613
24MP0002876_abnormal_thyroid_physiology1.68589562
25MP0001986_abnormal_taste_sensitivity1.64976278
26MP0006292_abnormal_olfactory_placode1.64537282
27MP0005171_absent_coat_pigmentation1.61003716
28MP0005084_abnormal_gallbladder_morpholo1.59315207
29MP0008875_abnormal_xenobiotic_pharmacok1.58484356
30MP0005645_abnormal_hypothalamus_physiol1.57307992
31MP0002736_abnormal_nociception_after1.54411764
32MP0003890_abnormal_embryonic-extraembry1.54406523
33MP0005174_abnormal_tail_pigmentation1.53459644
34MP0009046_muscle_twitch1.49263071
35MP0002160_abnormal_reproductive_system1.45648499
36MP0002938_white_spotting1.45509307
37MP0002638_abnormal_pupillary_reflex1.45216293
38MP0003718_maternal_effect1.44680809
39MP0006276_abnormal_autonomic_nervous1.44414344
40MP0010386_abnormal_urinary_bladder1.42542325
41MP0010094_abnormal_chromosome_stability1.37912477
42MP0000383_abnormal_hair_follicle1.37325607
43MP0002163_abnormal_gland_morphology1.35147436
44MP0005389_reproductive_system_phenotype1.34491630
45MP0003252_abnormal_bile_duct1.32418350
46MP0009745_abnormal_behavioral_response1.31577489
47MP0000631_abnormal_neuroendocrine_gland1.29481794
48MP0002277_abnormal_respiratory_mucosa1.29279412
49MP0008995_early_reproductive_senescence1.28290482
50MP0003786_premature_aging1.27276437
51MP0005075_abnormal_melanosome_morpholog1.24384606
52MP0001485_abnormal_pinna_reflex1.23677958
53MP0002272_abnormal_nervous_system1.22200606
54MP0003011_delayed_dark_adaptation1.21326842
55MP0002095_abnormal_skin_pigmentation1.17701558
56MP0003693_abnormal_embryo_hatching1.16608089
57MP0005220_abnormal_exocrine_pancreas1.16145211
58MP0004145_abnormal_muscle_electrophysio1.14141207
59MP0001919_abnormal_reproductive_system1.12169026
60MP0001764_abnormal_homeostasis1.10461556
61MP0002210_abnormal_sex_determination1.10419759
62MP0001501_abnormal_sleep_pattern1.08303476
63MP0001929_abnormal_gametogenesis1.07574775
64MP0004885_abnormal_endolymph1.06642231
65MP0003698_abnormal_male_reproductive1.05187574
66MP0006035_abnormal_mitochondrial_morpho1.03446869
67MP0001984_abnormal_olfaction1.03324296
68MP0005332_abnormal_amino_acid1.02442630
69MP0001324_abnormal_eye_pigmentation1.00438015
70MP0008057_abnormal_DNA_replication0.98187436
71MP0005195_abnormal_posterior_eye0.98028616
72MP0001486_abnormal_startle_reflex0.96587630
73MP0002557_abnormal_social/conspecific_i0.94288218
74MP0002735_abnormal_chemical_nociception0.93645068
75MP0003119_abnormal_digestive_system0.93503243
76MP0000653_abnormal_sex_gland0.91497281
77MP0005410_abnormal_fertilization0.91491921
78MP0008775_abnormal_heart_ventricle0.91128192
79MP0003937_abnormal_limbs/digits/tail_de0.90330983
80MP0008961_abnormal_basal_metabolism0.90110145
81MP0003943_abnormal_hepatobiliary_system0.88618915
82MP0002572_abnormal_emotion/affect_behav0.86938116
83MP0005083_abnormal_biliary_tract0.86028378
84MP0001661_extended_life_span0.85991258
85MP0003283_abnormal_digestive_organ0.85168850
86MP0001145_abnormal_male_reproductive0.85073914
87MP0001970_abnormal_pain_threshold0.83543859
88MP0000647_abnormal_sebaceous_gland0.82422825
89MP0000538_abnormal_urinary_bladder0.82237792
90MP0005379_endocrine/exocrine_gland_phen0.82112647
91MP0003137_abnormal_impulse_conducting0.79043655
92MP0005085_abnormal_gallbladder_physiolo0.78499482
93MP0001119_abnormal_female_reproductive0.78053243
94MP0000015_abnormal_ear_pigmentation0.77997676
95MP0000230_abnormal_systemic_arterial0.77864422
96MP0002751_abnormal_autonomic_nervous0.77199884
97MP0004924_abnormal_behavior0.76722921
98MP0005386_behavior/neurological_phenoty0.76722921
99MP0002733_abnormal_thermal_nociception0.73903721
100MP0006036_abnormal_mitochondrial_physio0.73857362

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.48061628
2Congenital stationary night blindness (HP:0007642)3.95780784
3Pancreatic fibrosis (HP:0100732)3.66091493
4Abnormality of midbrain morphology (HP:0002418)3.65640632
5Molar tooth sign on MRI (HP:0002419)3.65640632
6Abnormality of the renal cortex (HP:0011035)3.45628030
7Nephronophthisis (HP:0000090)3.44652819
8True hermaphroditism (HP:0010459)3.33271634
9Type II lissencephaly (HP:0007260)3.25999060
10Abnormality of the renal medulla (HP:0100957)3.25659285
11Attenuation of retinal blood vessels (HP:0007843)2.90949468
12Medial flaring of the eyebrow (HP:0010747)2.81662612
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77255634
14Abnormality of alanine metabolism (HP:0010916)2.77255634
15Hyperalaninemia (HP:0003348)2.77255634
16Pendular nystagmus (HP:0012043)2.74138141
17Tubular atrophy (HP:0000092)2.67914210
18Abolished electroretinogram (ERG) (HP:0000550)2.59224604
19Decreased central vision (HP:0007663)2.54487730
20Cystic liver disease (HP:0006706)2.50796876
21Hyperventilation (HP:0002883)2.49710399
22Renal cortical cysts (HP:0000803)2.46255994
23Progressive inability to walk (HP:0002505)2.44363338
24Chronic hepatic failure (HP:0100626)2.44314539
25Cerebellar dysplasia (HP:0007033)2.42165479
26Abnormality of the pons (HP:0007361)2.40581548
27Lissencephaly (HP:0001339)2.40446220
28Patellar aplasia (HP:0006443)2.39262333
29Hypoplasia of the pons (HP:0012110)2.34072623
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.33442855
31Abnormal drinking behavior (HP:0030082)2.32935525
32Polydipsia (HP:0001959)2.32935525
33Increased CSF lactate (HP:0002490)2.29689062
34Aplasia/Hypoplasia of the patella (HP:0006498)2.29673142
35Congenital hepatic fibrosis (HP:0002612)2.25955583
36Abnormal rod and cone electroretinograms (HP:0008323)2.25639438
37Mitochondrial inheritance (HP:0001427)2.21373390
38Gaze-evoked nystagmus (HP:0000640)2.19676027
39Lipid accumulation in hepatocytes (HP:0006561)2.18898974
40Acute necrotizing encephalopathy (HP:0006965)2.18733802
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17402954
42Methylmalonic acidemia (HP:0002912)2.16377577
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.15340035
44Genetic anticipation (HP:0003743)2.14238304
45Gait imbalance (HP:0002141)2.13260405
46Nephrogenic diabetes insipidus (HP:0009806)2.12646183
47Congenital primary aphakia (HP:0007707)2.11866256
48Colon cancer (HP:0003003)2.11025210
49Sclerocornea (HP:0000647)2.09946660
50Concave nail (HP:0001598)2.08168714
51Methylmalonic aciduria (HP:0012120)2.06217226
52Inability to walk (HP:0002540)2.04552328
53Birth length less than 3rd percentile (HP:0003561)2.04506605
54Keratoconus (HP:0000563)2.03498036
55Increased corneal curvature (HP:0100692)2.03498036
56Abnormality of DNA repair (HP:0003254)2.01182650
57Hepatocellular necrosis (HP:0001404)2.01121450
58Acute encephalopathy (HP:0006846)1.98770491
59Polyuria (HP:0000103)1.98684506
60Bile duct proliferation (HP:0001408)1.98404912
61Abnormal biliary tract physiology (HP:0012439)1.98404912
62Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97432591
63Abnormality of the ileum (HP:0001549)1.94740757
64Abnormal mitochondria in muscle tissue (HP:0008316)1.94687284
65Protruding tongue (HP:0010808)1.94541853
66Abnormality of the renal collecting system (HP:0004742)1.94435627
67Absent/shortened dynein arms (HP:0200106)1.94312844
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.94312844
69Retinal dysplasia (HP:0007973)1.92815506
70Small hand (HP:0200055)1.92718209
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92542373
72Abnormal protein N-linked glycosylation (HP:0012347)1.92542373
73Abnormal protein glycosylation (HP:0012346)1.92542373
74Abnormal glycosylation (HP:0012345)1.92542373
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.92359025
76Hepatic necrosis (HP:0002605)1.92153149
77Meckel diverticulum (HP:0002245)1.92152474
78Decreased circulating renin level (HP:0003351)1.91508920
79Clumsiness (HP:0002312)1.91480311
80Tubulointerstitial nephritis (HP:0001970)1.89730065
81Absent thumb (HP:0009777)1.89369000
82Type I transferrin isoform profile (HP:0003642)1.88886204
83Optic disc pallor (HP:0000543)1.86982739
84Bony spicule pigmentary retinopathy (HP:0007737)1.86773595
85Sloping forehead (HP:0000340)1.86336641
86Progressive macrocephaly (HP:0004481)1.84573493
87Anencephaly (HP:0002323)1.84395305
88Increased serum lactate (HP:0002151)1.84362896
89Enlarged kidneys (HP:0000105)1.84161247
90Chorioretinal atrophy (HP:0000533)1.83484609
91Congenital, generalized hypertrichosis (HP:0004540)1.80794375
92Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78318653
93Furrowed tongue (HP:0000221)1.77391386
94Stomach cancer (HP:0012126)1.77190489
95Oligohydramnios (HP:0001562)1.76659104
96Chromsome breakage (HP:0040012)1.75959224
97Large for gestational age (HP:0001520)1.75620023
98Severe muscular hypotonia (HP:0006829)1.74965715
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74835218
100Clubbing of toes (HP:0100760)1.72875907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.90848717
2BMPR1B3.63933073
3ACVR1B3.26714515
4ZAK3.16849846
5ADRBK22.75771564
6WNK42.57169092
7TAOK32.45331115
8GRK12.44829661
9TLK12.35380291
10NUAK12.24321842
11WNK32.08550833
12INSRR2.05705052
13PINK12.00125893
14MAP4K21.91765638
15MKNK21.68143029
16STK391.65347064
17OXSR11.63606052
18TRIM281.55653038
19BRSK21.49145353
20MAPK131.45261986
21MST41.44337240
22MAP3K41.39700415
23STK38L1.28517701
24PNCK1.28478455
25AKT31.21915868
26ADRBK11.21470489
27WEE11.20905032
28CASK1.17621152
29MAPKAPK31.13861234
30TGFBR11.07707464
31MAPK151.06064038
32BCKDK1.02538845
33PDK20.98938345
34LMTK20.95990901
35VRK10.95674772
36DAPK20.93601540
37MAP2K70.89042817
38STK160.88956273
39PIK3CA0.87925568
40PLK40.87539050
41MUSK0.87198691
42SRPK10.86148567
43MELK0.81587299
44TXK0.81007868
45NME10.80420560
46ATR0.80369846
47CAMKK20.79369345
48MAP2K60.76730183
49DYRK20.73884940
50FLT30.72517683
51LATS10.67276719
52BCR0.66441488
53PAK30.66140796
54IKBKB0.66130763
55PRKCQ0.65393193
56PTK2B0.65160552
57PRKCE0.65120819
58PLK10.64623580
59MKNK10.64168683
60CSNK1A1L0.62891127
61MAP2K20.62338244
62CDC70.62210408
63TNIK0.61129803
64NEK20.59693124
65CHEK20.59057599
66STK30.58971599
67STK110.57995946
68PRKCG0.56450337
69RPS6KA50.56355366
70EIF2AK30.55392255
71TEC0.53994945
72SIK20.53805387
73NLK0.53124859
74VRK20.52642983
75TAF10.50492299
76CSNK1G20.50252854
77CSNK1G10.49034019
78PLK30.48954713
79ERBB30.48230878
80PRKCI0.46916682
81ATM0.46461789
82CDK190.45556050
83MARK30.44394482
84PHKG10.42491335
85PHKG20.42491335
86CSNK1G30.42336305
87GRK70.41905471
88CDK80.40189779
89KIT0.39996250
90TNK20.39858722
91PRKACA0.37255543
92PLK20.37083601
93CCNB10.35688143
94CHUK0.33688439
95CAMK2A0.32172897
96PRKAA10.31867503
97OBSCN0.31220801
98PIM10.28088555
99MAPKAPK50.26881171
100CSNK1A10.26639012

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84370669
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.82004196
3Homologous recombination_Homo sapiens_hsa034402.76177202
4Phototransduction_Homo sapiens_hsa047442.62589370
5Fanconi anemia pathway_Homo sapiens_hsa034602.48329965
6RNA polymerase_Homo sapiens_hsa030202.23484360
7Selenocompound metabolism_Homo sapiens_hsa004502.23306507
8Nitrogen metabolism_Homo sapiens_hsa009102.19689993
9Linoleic acid metabolism_Homo sapiens_hsa005912.05480013
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00115848
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99438983
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96311754
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95764268
14Oxidative phosphorylation_Homo sapiens_hsa001901.91171129
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84119007
16One carbon pool by folate_Homo sapiens_hsa006701.80913491
17Basal transcription factors_Homo sapiens_hsa030221.80010056
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79177874
19Nicotine addiction_Homo sapiens_hsa050331.77782748
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77437223
21Non-homologous end-joining_Homo sapiens_hsa034501.73690669
22Butanoate metabolism_Homo sapiens_hsa006501.69075693
23Protein export_Homo sapiens_hsa030601.63053726
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59282164
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.51649702
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48257264
27RNA degradation_Homo sapiens_hsa030181.45859951
28Parkinsons disease_Homo sapiens_hsa050121.45828204
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44219360
30Tryptophan metabolism_Homo sapiens_hsa003801.43327391
31Taste transduction_Homo sapiens_hsa047421.39552999
32Propanoate metabolism_Homo sapiens_hsa006401.37432864
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.33081649
34Ether lipid metabolism_Homo sapiens_hsa005651.32951806
35Peroxisome_Homo sapiens_hsa041461.21930618
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19326531
37Caffeine metabolism_Homo sapiens_hsa002321.19174898
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.13973801
39Chemical carcinogenesis_Homo sapiens_hsa052041.13013205
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.11447905
41Sulfur relay system_Homo sapiens_hsa041221.10555654
42Huntingtons disease_Homo sapiens_hsa050161.08085970
43ABC transporters_Homo sapiens_hsa020101.06108062
44Morphine addiction_Homo sapiens_hsa050321.04978173
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04523969
46Regulation of autophagy_Homo sapiens_hsa041401.03653908
47Olfactory transduction_Homo sapiens_hsa047401.00022709
48Proteasome_Homo sapiens_hsa030500.98499148
49Pyrimidine metabolism_Homo sapiens_hsa002400.98003372
50Nucleotide excision repair_Homo sapiens_hsa034200.96713191
51Purine metabolism_Homo sapiens_hsa002300.95980931
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90927607
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87894858
54Retinol metabolism_Homo sapiens_hsa008300.86002602
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83413786
56Mismatch repair_Homo sapiens_hsa034300.82854669
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82780677
58Alzheimers disease_Homo sapiens_hsa050100.81240675
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79079101
60Ovarian steroidogenesis_Homo sapiens_hsa049130.72494221
61Cardiac muscle contraction_Homo sapiens_hsa042600.71687512
62beta-Alanine metabolism_Homo sapiens_hsa004100.71402870
63Arachidonic acid metabolism_Homo sapiens_hsa005900.70426276
64RNA transport_Homo sapiens_hsa030130.69966324
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.69565978
66GABAergic synapse_Homo sapiens_hsa047270.68610322
67Circadian rhythm_Homo sapiens_hsa047100.68003215
68Metabolic pathways_Homo sapiens_hsa011000.67746579
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66392802
70Base excision repair_Homo sapiens_hsa034100.62832526
71Primary immunodeficiency_Homo sapiens_hsa053400.61018808
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60767009
73Sulfur metabolism_Homo sapiens_hsa009200.59556516
74Glycerolipid metabolism_Homo sapiens_hsa005610.58407433
75Serotonergic synapse_Homo sapiens_hsa047260.56184649
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56027589
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55762870
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.53625625
79Histidine metabolism_Homo sapiens_hsa003400.52731832
80Collecting duct acid secretion_Homo sapiens_hsa049660.52505617
81Calcium signaling pathway_Homo sapiens_hsa040200.51715059
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50205521
83Fatty acid degradation_Homo sapiens_hsa000710.50013661
84Asthma_Homo sapiens_hsa053100.49174894
85Circadian entrainment_Homo sapiens_hsa047130.47682970
86Lysine degradation_Homo sapiens_hsa003100.47356158
87Insulin secretion_Homo sapiens_hsa049110.47117027
88Glutamatergic synapse_Homo sapiens_hsa047240.44770714
89Sphingolipid metabolism_Homo sapiens_hsa006000.41744396
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40948386
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40454967
92TGF-beta signaling pathway_Homo sapiens_hsa043500.38925189
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38659018
94Salivary secretion_Homo sapiens_hsa049700.37982247
95p53 signaling pathway_Homo sapiens_hsa041150.37266562
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37216091
97Steroid biosynthesis_Homo sapiens_hsa001000.36789157
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36594721
99Fatty acid metabolism_Homo sapiens_hsa012120.36392265
100Dorso-ventral axis formation_Homo sapiens_hsa043200.34114137

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