ZNF696

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.81092578
2maturation of SSU-rRNA (GO:0030490)5.02261339
3viral transcription (GO:0019083)4.64441797
4behavioral response to nicotine (GO:0035095)4.44812833
5translational termination (GO:0006415)4.44804383
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.43931273
7regulation of mitochondrial translation (GO:0070129)4.34928746
8metallo-sulfur cluster assembly (GO:0031163)4.13850804
9iron-sulfur cluster assembly (GO:0016226)4.13850804
10translational elongation (GO:0006414)3.97638210
11ribonucleoprotein complex biogenesis (GO:0022613)3.90733625
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.89794827
13NADH dehydrogenase complex assembly (GO:0010257)3.89794827
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89794827
15ribosomal small subunit assembly (GO:0000028)3.86716989
16mitochondrial respiratory chain complex assembly (GO:0033108)3.86521640
17cell migration in hindbrain (GO:0021535)3.83974302
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.82074864
19chaperone-mediated protein transport (GO:0072321)3.70150888
20protein complex biogenesis (GO:0070271)3.66828838
21viral life cycle (GO:0019058)3.62043424
22regulation of nuclear cell cycle DNA replication (GO:0033262)3.61651002
23cellular component biogenesis (GO:0044085)3.60874169
24ribosome biogenesis (GO:0042254)3.59545537
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53469525
26peptidyl-histidine modification (GO:0018202)3.51358498
27cotranslational protein targeting to membrane (GO:0006613)3.48884912
28tRNA modification (GO:0006400)3.47965018
29pseudouridine synthesis (GO:0001522)3.46120946
30protein targeting to ER (GO:0045047)3.43918695
31cellular protein complex disassembly (GO:0043624)3.37522500
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.28171281
33mitochondrial calcium ion transport (GO:0006851)3.27956992
34ribosomal large subunit biogenesis (GO:0042273)3.27256665
35protein complex disassembly (GO:0043241)3.22177106
36establishment of mitochondrion localization (GO:0051654)3.21937068
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20926656
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20926656
39protein localization to endoplasmic reticulum (GO:0070972)3.15657332
40translational initiation (GO:0006413)3.12903216
41positive regulation of mitochondrial fission (GO:0090141)3.10956065
42rRNA processing (GO:0006364)3.08472203
43macromolecular complex disassembly (GO:0032984)3.06639917
44pyrimidine nucleobase catabolic process (GO:0006208)3.02524350
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00952387
46rRNA metabolic process (GO:0016072)2.98146585
47UTP biosynthetic process (GO:0006228)2.97363026
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93025451
49mitochondrion transport along microtubule (GO:0047497)2.93025451
50spliceosomal complex assembly (GO:0000245)2.88604015
51ATP synthesis coupled proton transport (GO:0015986)2.86491343
52energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86491343
53ubiquinone biosynthetic process (GO:0006744)2.85422417
54tRNA processing (GO:0008033)2.83298604
55DNA replication checkpoint (GO:0000076)2.83081853
56mitochondrial RNA metabolic process (GO:0000959)2.79697664
57GTP biosynthetic process (GO:0006183)2.76911074
58nuclear-transcribed mRNA catabolic process (GO:0000956)2.76519049
59DNA damage response, detection of DNA damage (GO:0042769)2.75318613
60negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74879785
61spliceosomal snRNP assembly (GO:0000387)2.74767108
62ncRNA processing (GO:0034470)2.73468499
63UTP metabolic process (GO:0046051)2.73197481
64ubiquinone metabolic process (GO:0006743)2.72497384
65mitochondrion morphogenesis (GO:0070584)2.71969558
66translation (GO:0006412)2.71832174
67mRNA catabolic process (GO:0006402)2.70986996
68postsynaptic membrane organization (GO:0001941)2.70460453
69L-serine metabolic process (GO:0006563)2.69585264
70pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.68587147
71ncRNA 3-end processing (GO:0043628)2.63984232
72establishment of protein localization to mitochondrion (GO:0072655)2.62031718
73protein-cofactor linkage (GO:0018065)2.62009170
74pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.61759802
75maturation of 5.8S rRNA (GO:0000460)2.61339018
76intracellular protein transmembrane import (GO:0044743)2.59316754
77negative regulation of telomere maintenance (GO:0032205)2.57841857
78protein targeting to mitochondrion (GO:0006626)2.57650505
79tRNA methylation (GO:0030488)2.57624657
80proline metabolic process (GO:0006560)2.56711128
81peptidyl-arginine N-methylation (GO:0035246)2.56642914
82peptidyl-arginine methylation (GO:0018216)2.56642914
83nuclear envelope reassembly (GO:0031468)2.55352714
84mitotic nuclear envelope reassembly (GO:0007084)2.55352714
85negative regulation of DNA-templated transcription, elongation (GO:0032785)2.54964998
86chromatin remodeling at centromere (GO:0031055)2.53573017
87RNA catabolic process (GO:0006401)2.51670705
88termination of RNA polymerase III transcription (GO:0006386)2.51319962
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.51319962
90ncRNA metabolic process (GO:0034660)2.50799051
91termination of RNA polymerase II transcription (GO:0006369)2.49507089
92inner mitochondrial membrane organization (GO:0007007)2.49149028
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.48361378
94mitochondrial fusion (GO:0008053)2.47942644
95heterochromatin organization (GO:0070828)2.47260130
96peptidyl-arginine omega-N-methylation (GO:0035247)2.45519465
97chaperone-mediated protein complex assembly (GO:0051131)2.45352948
98regulation of development, heterochronic (GO:0040034)2.43323438
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.42437690
100tRNA metabolic process (GO:0006399)2.40893679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.93996012
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65859732
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27011035
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.21912027
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09259853
6XRN2_22483619_ChIP-Seq_HELA_Human3.02746921
7* ETS1_20019798_ChIP-Seq_JURKAT_Human2.80708893
8THAP11_20581084_ChIP-Seq_MESCs_Mouse2.63132664
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58289270
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40480389
11E2F7_22180533_ChIP-Seq_HELA_Human2.32668978
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16640660
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15522332
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.15294814
15TTF2_22483619_ChIP-Seq_HELA_Human2.13901808
16* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10130305
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06712839
18* GABP_19822575_ChIP-Seq_HepG2_Human2.06052601
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02622454
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99151821
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.90799673
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89133460
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88562950
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.88233650
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87550047
26* DCP1A_22483619_ChIP-Seq_HELA_Human1.85818442
27* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84054862
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.83269355
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79635788
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79466915
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79077244
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73028552
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68049265
34EZH2_22144423_ChIP-Seq_EOC_Human1.66598248
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66460137
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.65418269
37* KDM5A_27292631_Chip-Seq_BREAST_Human1.64434128
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57569691
39ZNF274_21170338_ChIP-Seq_K562_Hela1.54254314
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.53874507
41FOXP1_21924763_ChIP-Seq_HESCs_Human1.53377311
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53139422
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53095914
44* P68_20966046_ChIP-Seq_HELA_Human1.53008771
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52660219
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.52639743
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.52633824
48CIITA_25753668_ChIP-Seq_RAJI_Human1.51299970
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.51188239
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50857459
51VDR_21846776_ChIP-Seq_THP-1_Human1.49594751
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46750277
53ZNF263_19887448_ChIP-Seq_K562_Human1.41767761
54VDR_23849224_ChIP-Seq_CD4+_Human1.41395040
55FOXP3_21729870_ChIP-Seq_TREG_Human1.41292036
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40738494
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39108648
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.38599093
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35251166
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34459034
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33639110
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32167240
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31829602
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31749320
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31518954
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.27706445
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25968608
68MYC_18940864_ChIP-ChIP_HL60_Human1.25845803
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22402998
70IRF1_19129219_ChIP-ChIP_H3396_Human1.21702036
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20913118
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18830487
73LXR_22292898_ChIP-Seq_THP-1_Human1.17259613
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14146928
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.12283143
76* MYC_22102868_ChIP-Seq_BL_Human1.11604352
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10646649
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10130404
79PHF8_20622854_ChIP-Seq_HELA_Human1.09966107
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09526107
81BCL6_27268052_Chip-Seq_Bcells_Human1.09224202
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08186351
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07388080
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07341705
85E2F1_20622854_ChIP-Seq_HELA_Human1.06431873
86CTCF_27219007_Chip-Seq_Bcells_Human1.05868964
87RARA_24833708_ChIP-Seq_LIVER_Mouse1.04225124
88* ERA_21632823_ChIP-Seq_H3396_Human1.03837315
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01791737
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.01453190
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01411162
92ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98906311
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97337397
94* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97054679
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95521194
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.94909778
97BCOR_27268052_Chip-Seq_Bcells_Human0.93688189
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.92673354
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.92510086
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92053652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.87411637
2MP0001529_abnormal_vocalization2.75325313
3MP0000049_abnormal_middle_ear2.64353861
4MP0003693_abnormal_embryo_hatching2.49852066
5MP0003136_yellow_coat_color2.29126603
6MP0009379_abnormal_foot_pigmentation2.27337010
7MP0008789_abnormal_olfactory_epithelium2.14316379
8MP0010030_abnormal_orbit_morphology2.11539254
9MP0003111_abnormal_nucleus_morphology2.10365321
10MP0002249_abnormal_larynx_morphology1.98550982
11MP0005499_abnormal_olfactory_system1.95894899
12MP0005394_taste/olfaction_phenotype1.95894899
13MP0005645_abnormal_hypothalamus_physiol1.88361675
14MP0010094_abnormal_chromosome_stability1.88003146
15MP0004133_heterotaxia1.72530740
16MP0008932_abnormal_embryonic_tissue1.71133738
17MP0002102_abnormal_ear_morphology1.66796479
18MP0003937_abnormal_limbs/digits/tail_de1.60518491
19MP0004858_abnormal_nervous_system1.57662313
20MP0000631_abnormal_neuroendocrine_gland1.57403431
21MP0002736_abnormal_nociception_after1.57196399
22MP0003077_abnormal_cell_cycle1.56481678
23MP0001986_abnormal_taste_sensitivity1.55273053
24MP0000778_abnormal_nervous_system1.54703607
25MP0001293_anophthalmia1.53095834
26MP0002653_abnormal_ependyma_morphology1.52038798
27MP0000537_abnormal_urethra_morphology1.48982323
28MP0002234_abnormal_pharynx_morphology1.41571714
29MP0003567_abnormal_fetal_cardiomyocyte1.41498907
30MP0009278_abnormal_bone_marrow1.40079270
31MP0003315_abnormal_perineum_morphology1.39906419
32MP0003938_abnormal_ear_development1.36403438
33MP0002160_abnormal_reproductive_system1.34905243
34MP0001968_abnormal_touch/_nociception1.33303897
35MP0002938_white_spotting1.32473319
36MP0003718_maternal_effect1.29769349
37MP0006276_abnormal_autonomic_nervous1.25046972
38MP0004142_abnormal_muscle_tone1.21717687
39MP0001919_abnormal_reproductive_system1.21581860
40MP0003119_abnormal_digestive_system1.20684604
41MP0002638_abnormal_pupillary_reflex1.20374404
42MP0003122_maternal_imprinting1.20170713
43MP0003861_abnormal_nervous_system1.18004835
44MP0001286_abnormal_eye_development1.17304705
45MP0005083_abnormal_biliary_tract1.17066139
46MP0002163_abnormal_gland_morphology1.16820295
47MP0000026_abnormal_inner_ear1.16717870
48MP0003942_abnormal_urinary_system1.16541523
49MP0008058_abnormal_DNA_repair1.15981229
50MP0002697_abnormal_eye_size1.15547911
51MP0000566_synostosis1.15315483
52MP0001984_abnormal_olfaction1.12681490
53MP0008995_early_reproductive_senescence1.12388039
54MP0003283_abnormal_digestive_organ1.11585776
55MP0002111_abnormal_tail_morphology1.10798308
56MP0000678_abnormal_parathyroid_gland1.09321075
57MP0002210_abnormal_sex_determination1.08212118
58MP0005646_abnormal_pituitary_gland1.07667695
59MP0005423_abnormal_somatic_nervous1.06566772
60MP0005389_reproductive_system_phenotype1.06182960
61MP0006072_abnormal_retinal_apoptosis1.05475531
62MP0008007_abnormal_cellular_replicative1.04995409
63MP0006035_abnormal_mitochondrial_morpho1.04965912
64MP0005551_abnormal_eye_electrophysiolog1.03952749
65MP0001502_abnormal_circadian_rhythm1.03199470
66MP0003121_genomic_imprinting1.01943578
67MP0005187_abnormal_penis_morphology0.99079913
68MP0002751_abnormal_autonomic_nervous0.98046826
69MP0002752_abnormal_somatic_nervous0.96717745
70MP0003880_abnormal_central_pattern0.95691077
71MP0004957_abnormal_blastocyst_morpholog0.95581383
72MP0003755_abnormal_palate_morphology0.95233506
73MP0002822_catalepsy0.94833752
74MP0001905_abnormal_dopamine_level0.94371291
75MP0001485_abnormal_pinna_reflex0.94225786
76MP0005195_abnormal_posterior_eye0.92737784
77MP0005084_abnormal_gallbladder_morpholo0.92172311
78MP0004742_abnormal_vestibular_system0.90779199
79MP0002152_abnormal_brain_morphology0.89574945
80MP0002092_abnormal_eye_morphology0.87970430
81MP0003385_abnormal_body_wall0.87548948
82MP0005391_vision/eye_phenotype0.87148650
83MP0005377_hearing/vestibular/ear_phenot0.86842119
84MP0003878_abnormal_ear_physiology0.86842119
85MP0002233_abnormal_nose_morphology0.86151687
86MP0002557_abnormal_social/conspecific_i0.83976500
87MP0004811_abnormal_neuron_physiology0.83286936
88MP0002932_abnormal_joint_morphology0.83088504
89MP0002085_abnormal_embryonic_tissue0.82623142
90MP0004145_abnormal_muscle_electrophysio0.82405226
91MP0004197_abnormal_fetal_growth/weight/0.81425674
92MP0000955_abnormal_spinal_cord0.80973064
93MP0000647_abnormal_sebaceous_gland0.78659818
94MP0002116_abnormal_craniofacial_bone0.78117616
95MP0002882_abnormal_neuron_morphology0.78030531
96MP0002733_abnormal_thermal_nociception0.78019181
97MP0005379_endocrine/exocrine_gland_phen0.77875442
98MP0000350_abnormal_cell_proliferation0.77870646
99MP0003698_abnormal_male_reproductive0.74817523
100MP0002177_abnormal_outer_ear0.74533871

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.44734313
2Abnormality of cells of the erythroid lineage (HP:0012130)4.22257502
3Aplasia/Hypoplasia of the patella (HP:0006498)3.38887256
4Breast hypoplasia (HP:0003187)3.19401469
5Birth length less than 3rd percentile (HP:0003561)3.16107192
6Patellar aplasia (HP:0006443)3.09828195
7Reticulocytopenia (HP:0001896)2.97148715
8Pendular nystagmus (HP:0012043)2.93619198
9Rib fusion (HP:0000902)2.90943837
10Abnormal mitochondria in muscle tissue (HP:0008316)2.85261574
11Acute necrotizing encephalopathy (HP:0006965)2.68002885
12Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65795073
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65795073
14Concave nail (HP:0001598)2.65281510
15Congenital stationary night blindness (HP:0007642)2.56021778
16Mitochondrial inheritance (HP:0001427)2.55536833
17Type II lissencephaly (HP:0007260)2.49754579
18Partial agenesis of the corpus callosum (HP:0001338)2.49256092
19Abnormality of alanine metabolism (HP:0010916)2.46624446
20Hyperalaninemia (HP:0003348)2.46624446
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46624446
22Increased intramyocellular lipid droplets (HP:0012240)2.44669683
23Hepatocellular necrosis (HP:0001404)2.40976114
24Fibular aplasia (HP:0002990)2.34073318
25Retinal dysplasia (HP:0007973)2.32564737
26Increased CSF lactate (HP:0002490)2.30003642
27Acute encephalopathy (HP:0006846)2.29503753
28Cortical dysplasia (HP:0002539)2.28500157
29Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.27465907
30Short 1st metacarpal (HP:0010034)2.27465907
31Absent thumb (HP:0009777)2.25908924
32Abnormal number of incisors (HP:0011064)2.23464264
33Hyperglycinuria (HP:0003108)2.22468728
34Pallor (HP:0000980)2.21238353
35Increased serum lactate (HP:0002151)2.21073448
36Progressive microcephaly (HP:0000253)2.15201949
37Macrocytic anemia (HP:0001972)2.14275738
38Hepatic necrosis (HP:0002605)2.11931287
39Abnormality of reticulocytes (HP:0004312)2.10082327
40Increased muscle lipid content (HP:0009058)2.09596326
41Hypoplasia of the radius (HP:0002984)2.08411701
42Short thumb (HP:0009778)2.06891423
43Molar tooth sign on MRI (HP:0002419)2.03729377
44Abnormality of midbrain morphology (HP:0002418)2.03729377
45Nephronophthisis (HP:0000090)2.00888068
46Gait imbalance (HP:0002141)1.99707948
47Pancreatic cysts (HP:0001737)1.99007870
48Broad distal phalanx of finger (HP:0009836)1.98628840
49Abnormality of the 1st metacarpal (HP:0010009)1.95242833
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94638149
51Increased hepatocellular lipid droplets (HP:0006565)1.92798093
52Lissencephaly (HP:0001339)1.92729492
53Humeroradial synostosis (HP:0003041)1.91942289
54Synostosis involving the elbow (HP:0003938)1.91942289
55Abnormality of glycine metabolism (HP:0010895)1.90755309
56Abnormality of serine family amino acid metabolism (HP:0010894)1.90755309
57Microretrognathia (HP:0000308)1.89506599
5811 pairs of ribs (HP:0000878)1.89154923
59Shoulder girdle muscle weakness (HP:0003547)1.89026921
60Pachygyria (HP:0001302)1.88271014
61Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86627054
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.86430721
63Hypoplasia of the pons (HP:0012110)1.85503441
64Congenital primary aphakia (HP:0007707)1.83301323
65Progressive macrocephaly (HP:0004481)1.82396695
66Lipid accumulation in hepatocytes (HP:0006561)1.81937208
67Lactic acidosis (HP:0003128)1.80653623
68Abnormality of the pons (HP:0007361)1.79680696
69Medial flaring of the eyebrow (HP:0010747)1.79593674
70Short phalanx of the thumb (HP:0009660)1.79272776
71Meckel diverticulum (HP:0002245)1.78346176
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76870189
73True hermaphroditism (HP:0010459)1.76400465
74Squamous cell carcinoma (HP:0002860)1.75925465
75Abnormality of the ileum (HP:0001549)1.75211649
76Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74222904
77Cerebral edema (HP:0002181)1.73916900
78Abnormality of the 2nd finger (HP:0004100)1.73298838
79Septo-optic dysplasia (HP:0100842)1.72103687
80Abnormality of the carotid arteries (HP:0005344)1.71919951
81Cerebellar hypoplasia (HP:0001321)1.71324239
82Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71165205
83Hypoplasia of the brainstem (HP:0002365)1.71165205
84Poor suck (HP:0002033)1.70276063
85Elfin facies (HP:0004428)1.69508144
86Bilateral microphthalmos (HP:0007633)1.69457936
87Reticulocytosis (HP:0001923)1.68840354
88Delayed CNS myelination (HP:0002188)1.67807083
89Hyperacusis (HP:0010780)1.67455107
90Polymicrogyria (HP:0002126)1.65005334
91Hyperglycinemia (HP:0002154)1.64968814
92Trigonocephaly (HP:0000243)1.64768523
93Triphalangeal thumb (HP:0001199)1.64321864
94Optic disc pallor (HP:0000543)1.63560981
95Short 5th finger (HP:0009237)1.62574562
96Fibular hypoplasia (HP:0003038)1.61931345
97Chorioretinal atrophy (HP:0000533)1.61746834
98Poor coordination (HP:0002370)1.61476596
99Hemivertebrae (HP:0002937)1.60388001
100High anterior hairline (HP:0009890)1.60034502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.34765400
2PLK43.29276013
3SRPK12.99737732
4NME22.73212732
5TLK12.69462254
6DYRK32.44803358
7NME12.31087851
8CDC72.19109905
9WNK42.09753381
10RPS6KA42.08154581
11BCKDK1.99262942
12DYRK21.87360231
13SIK21.80521531
14SIK11.78563334
15MAPK151.74004388
16EPHB21.70386387
17MAP2K71.69362399
18EPHA21.68407269
19PDK21.62288996
20MAP3K111.59970713
21NEK21.59222597
22PIM21.51944349
23BUB11.49341213
24STK161.48464195
25ICK1.43461801
26CASK1.38212679
27AURKA1.36685094
28BMPR1B1.32525434
29DYRK1B1.31855272
30VRK21.30182357
31WEE11.27882907
32MAP3K101.24503870
33PNCK1.19952981
34CHEK21.19578637
35NTRK21.17785106
36PLK11.17318723
37ATR1.14034900
38MAP3K41.10540094
39MAP4K21.10539780
40RPS6KA51.09921556
41NEK11.09313680
42INSRR1.07443448
43MKNK21.05415089
44MARK11.00663070
45WNK30.95523176
46RPS6KA60.92860829
47AURKB0.90138677
48TRIB30.87099285
49VRK10.86963026
50MAPKAPK30.83886548
51TTK0.81410065
52EEF2K0.78752054
53MKNK10.76742922
54MAP2K20.76056033
55MUSK0.75438729
56TESK20.75200761
57CHEK10.74967496
58IRAK30.74759754
59PRKCI0.70735673
60BMX0.70551858
61MAP3K90.69671958
62RPS6KL10.69285118
63RPS6KC10.69285118
64DMPK0.66331569
65SMG10.65815349
66RPS6KB20.64052869
67PKN10.64034548
68CDK70.62919054
69RPS6KA10.61951817
70ADRBK20.61616201
71TRIM280.60622319
72TSSK60.59642688
73RPS6KA20.59432959
74CDK40.58768254
75CSNK2A20.57495175
76CDK20.56032576
77LATS20.55948918
78PRKCG0.55705244
79MAP4K10.55621075
80CSNK2A10.55511838
81CAMK2B0.52729805
82DAPK10.51408022
83PHKG20.50240884
84PHKG10.50240884
85ALK0.49753253
86AKT10.49494554
87LMTK20.48707332
88CDK10.48398622
89AKT20.47407459
90UHMK10.46887953
91CAMK1D0.46317494
92CSNK1E0.45193677
93PASK0.43922264
94MAPK130.42899130
95PRKG20.42264480
96TNIK0.42222863
97MTOR0.40842702
98ATM0.40564237
99PIM10.39172335
100CAMK2G0.38792854

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.92590375
2Ribosome_Homo sapiens_hsa030104.50182337
3Base excision repair_Homo sapiens_hsa034102.94521021
4Selenocompound metabolism_Homo sapiens_hsa004502.89135946
5Spliceosome_Homo sapiens_hsa030402.64265535
6DNA replication_Homo sapiens_hsa030302.54356880
7Oxidative phosphorylation_Homo sapiens_hsa001902.46244457
8RNA polymerase_Homo sapiens_hsa030202.31891479
9Folate biosynthesis_Homo sapiens_hsa007902.31719835
10Parkinsons disease_Homo sapiens_hsa050122.15076220
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98916639
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97859923
13Pyrimidine metabolism_Homo sapiens_hsa002401.95895890
14Homologous recombination_Homo sapiens_hsa034401.95479685
15Fanconi anemia pathway_Homo sapiens_hsa034601.85251329
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84011923
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79693020
18RNA transport_Homo sapiens_hsa030131.76861771
19Huntingtons disease_Homo sapiens_hsa050161.75605464
20Mismatch repair_Homo sapiens_hsa034301.70476406
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66695379
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.59352207
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48712945
24Basal cell carcinoma_Homo sapiens_hsa052171.46984920
25RNA degradation_Homo sapiens_hsa030181.44697681
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42506119
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37765778
28Cardiac muscle contraction_Homo sapiens_hsa042601.35094170
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31743794
30Nucleotide excision repair_Homo sapiens_hsa034201.31271808
31Alzheimers disease_Homo sapiens_hsa050101.30427075
32Basal transcription factors_Homo sapiens_hsa030221.27500961
33Fructose and mannose metabolism_Homo sapiens_hsa000511.25202428
34Nicotine addiction_Homo sapiens_hsa050331.19277332
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17883641
36Biosynthesis of amino acids_Homo sapiens_hsa012301.16803890
37mRNA surveillance pathway_Homo sapiens_hsa030151.15864079
38One carbon pool by folate_Homo sapiens_hsa006701.11683687
39Notch signaling pathway_Homo sapiens_hsa043301.09934430
40Phototransduction_Homo sapiens_hsa047441.08027651
41Steroid biosynthesis_Homo sapiens_hsa001001.06691038
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06405480
43Purine metabolism_Homo sapiens_hsa002300.96073631
44Hedgehog signaling pathway_Homo sapiens_hsa043400.94130860
45Cell cycle_Homo sapiens_hsa041100.93892235
46Hippo signaling pathway_Homo sapiens_hsa043900.89598817
47Alcoholism_Homo sapiens_hsa050340.86906811
48Proteasome_Homo sapiens_hsa030500.86183512
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85584607
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84930909
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81523018
52Pyruvate metabolism_Homo sapiens_hsa006200.78909111
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.77340267
54Metabolic pathways_Homo sapiens_hsa011000.69423499
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66726122
56Vitamin B6 metabolism_Homo sapiens_hsa007500.66723163
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66320490
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61026722
59Non-homologous end-joining_Homo sapiens_hsa034500.59612130
60Axon guidance_Homo sapiens_hsa043600.58877385
61Carbon metabolism_Homo sapiens_hsa012000.58244841
62Lysine degradation_Homo sapiens_hsa003100.54958740
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54843617
64Cocaine addiction_Homo sapiens_hsa050300.53909175
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53690386
66Ether lipid metabolism_Homo sapiens_hsa005650.50802065
67Arginine and proline metabolism_Homo sapiens_hsa003300.49667935
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46344592
69Peroxisome_Homo sapiens_hsa041460.44594027
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43716553
71Taste transduction_Homo sapiens_hsa047420.43493204
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40845011
73Bladder cancer_Homo sapiens_hsa052190.40604657
74Butanoate metabolism_Homo sapiens_hsa006500.39663841
75Linoleic acid metabolism_Homo sapiens_hsa005910.37662792
76Nitrogen metabolism_Homo sapiens_hsa009100.34584539
77Systemic lupus erythematosus_Homo sapiens_hsa053220.34289965
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33947777
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33887478
80Glutathione metabolism_Homo sapiens_hsa004800.33314017
81Melanoma_Homo sapiens_hsa052180.33043761
82Protein export_Homo sapiens_hsa030600.32881496
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32629855
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32518986
85Wnt signaling pathway_Homo sapiens_hsa043100.32142483
86Morphine addiction_Homo sapiens_hsa050320.30428515
87p53 signaling pathway_Homo sapiens_hsa041150.27730464
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.27227635
89ABC transporters_Homo sapiens_hsa020100.26301719
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25923204
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22631163
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22339168
93Pentose phosphate pathway_Homo sapiens_hsa000300.21636071
94TGF-beta signaling pathway_Homo sapiens_hsa043500.21414191
95Synaptic vesicle cycle_Homo sapiens_hsa047210.20742106
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20150247
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.18940573
98Melanogenesis_Homo sapiens_hsa049160.18266468
99AMPK signaling pathway_Homo sapiens_hsa041520.17929287
100Oocyte meiosis_Homo sapiens_hsa041140.17888280

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