ZNF688

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.77099337
2DNA deamination (GO:0045006)5.42246163
3sulfation (GO:0051923)4.54609995
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.23010564
5NADH dehydrogenase complex assembly (GO:0010257)4.23010564
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23010564
7water-soluble vitamin biosynthetic process (GO:0042364)4.14173066
8protein complex biogenesis (GO:0070271)3.93998938
9cell proliferation in forebrain (GO:0021846)3.73704046
10cellular response to ATP (GO:0071318)3.70583493
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65273808
12indolalkylamine metabolic process (GO:0006586)3.64954819
13negative regulation of mast cell activation (GO:0033004)3.57368816
14protein polyglutamylation (GO:0018095)3.54252403
15tryptophan catabolic process (GO:0006569)3.54076280
16indole-containing compound catabolic process (GO:0042436)3.54076280
17indolalkylamine catabolic process (GO:0046218)3.54076280
18mitochondrial respiratory chain complex assembly (GO:0033108)3.49313041
19tryptophan metabolic process (GO:0006568)3.48248939
20pharyngeal system development (GO:0060037)3.47863544
21negative regulation of systemic arterial blood pressure (GO:0003085)3.45892536
22kynurenine metabolic process (GO:0070189)3.41758483
23positive regulation of cAMP-mediated signaling (GO:0043950)3.38463416
24cytidine deamination (GO:0009972)3.34518885
25cytidine metabolic process (GO:0046087)3.34518885
26cytidine catabolic process (GO:0006216)3.34518885
27regulation of mesoderm development (GO:2000380)3.23607383
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21413348
29axoneme assembly (GO:0035082)3.20761784
30somite development (GO:0061053)3.19242274
31preassembly of GPI anchor in ER membrane (GO:0016254)3.13373378
32detection of light stimulus involved in visual perception (GO:0050908)3.13020404
33detection of light stimulus involved in sensory perception (GO:0050962)3.13020404
34regulation of glomerulus development (GO:0090192)3.12604054
35regulation of germinal center formation (GO:0002634)3.11232960
36negative regulation of telomere maintenance (GO:0032205)3.10708549
37L-fucose catabolic process (GO:0042355)3.05566829
38fucose catabolic process (GO:0019317)3.05566829
39L-fucose metabolic process (GO:0042354)3.05566829
40positive regulation of defense response to virus by host (GO:0002230)3.04431005
41purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.02181345
423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.02181345
43regulation of female receptivity (GO:0045924)2.98160252
44cellular response to exogenous dsRNA (GO:0071360)2.95970261
45indole-containing compound metabolic process (GO:0042430)2.95434249
46cellular anion homeostasis (GO:0030002)2.91294784
47gamma-aminobutyric acid transport (GO:0015812)2.88847033
48serotonin metabolic process (GO:0042428)2.88095193
49positive regulation of cardiac muscle cell differentiation (GO:2000727)2.86756675
50DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.86457321
51parturition (GO:0007567)2.82390373
52positive regulation of fatty acid transport (GO:2000193)2.82378033
53primary amino compound metabolic process (GO:1901160)2.82346200
54pyrimidine ribonucleoside catabolic process (GO:0046133)2.78358566
55regulation of action potential (GO:0098900)2.76950925
56positive regulation of fatty acid oxidation (GO:0046321)2.75792615
57adaptation of signaling pathway (GO:0023058)2.75102860
58negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.73616382
59positive regulation of digestive system process (GO:0060456)2.72234096
60negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71760605
61GPI anchor metabolic process (GO:0006505)2.70446856
62epithelial cilium movement (GO:0003351)2.68585708
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68498184
64negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67029138
65neuronal action potential (GO:0019228)2.66940786
66negative regulation of appetite (GO:0032099)2.62568274
67negative regulation of response to food (GO:0032096)2.62568274
68positive regulation of prostaglandin secretion (GO:0032308)2.59087302
69regulation of cell proliferation involved in kidney development (GO:1901722)2.57658700
70positive regulation of potassium ion transmembrane transport (GO:1901381)2.52461119
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.52263373
72female mating behavior (GO:0060180)2.50441364
73positive regulation of icosanoid secretion (GO:0032305)2.50311270
74piRNA metabolic process (GO:0034587)2.49838901
75DNA damage response, signal transduction resulting in transcription (GO:0042772)2.48462309
76endoderm formation (GO:0001706)2.48057386
77multicellular organism reproduction (GO:0032504)2.45634032
78negative regulation of multicellular organism growth (GO:0040015)2.45621249
79transmission of nerve impulse (GO:0019226)2.45133415
80positive regulation of glomerulus development (GO:0090193)2.45051532
81energy coupled proton transport, down electrochemical gradient (GO:0015985)2.44845948
82ATP synthesis coupled proton transport (GO:0015986)2.44845948
83regulation of skeletal muscle contraction (GO:0014819)2.43404878
84positive regulation of oligodendrocyte differentiation (GO:0048714)2.43179809
85amine catabolic process (GO:0009310)2.42770267
86cellular biogenic amine catabolic process (GO:0042402)2.42770267
87regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42393874
88negative regulation of T cell differentiation in thymus (GO:0033085)2.40972374
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40397810
90response to xenobiotic stimulus (GO:0009410)2.39686453
91photoreceptor cell development (GO:0042461)2.38359207
92flavonoid metabolic process (GO:0009812)2.38106997
93cilium movement (GO:0003341)2.35040686
94DNA methylation involved in gamete generation (GO:0043046)2.32965248
95mannosylation (GO:0097502)2.32292575
96membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.32106306
97regulation of sequestering of triglyceride (GO:0010889)2.31210212
98rRNA catabolic process (GO:0016075)2.30960870
99spinal cord motor neuron differentiation (GO:0021522)2.29493308
100synaptic transmission, cholinergic (GO:0007271)2.29400199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.01833440
2EZH2_22144423_ChIP-Seq_EOC_Human4.63825028
3ZNF274_21170338_ChIP-Seq_K562_Hela2.81118422
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78573628
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.72715917
6VDR_22108803_ChIP-Seq_LS180_Human2.38812486
7GBX2_23144817_ChIP-Seq_PC3_Human2.24787531
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03839072
9EED_16625203_ChIP-ChIP_MESCs_Mouse1.98470974
10ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83870455
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79898211
12IRF8_22096565_ChIP-ChIP_GC-B_Human1.78872650
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78482141
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78318946
15IRF1_19129219_ChIP-ChIP_H3396_Human1.74474920
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72312047
17IGF1R_20145208_ChIP-Seq_DFB_Human1.68096670
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.67068104
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65413376
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64321398
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55447000
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.53675195
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.53398374
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51547139
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.51359992
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51218683
27EWS_26573619_Chip-Seq_HEK293_Human1.50498362
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49605288
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44383224
30REST_21632747_ChIP-Seq_MESCs_Mouse1.42562441
31ER_23166858_ChIP-Seq_MCF-7_Human1.38147104
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37761833
33* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.36095668
34FUS_26573619_Chip-Seq_HEK293_Human1.35338035
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34472725
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32877028
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32471997
38TP53_22573176_ChIP-Seq_HFKS_Human1.32211516
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30769649
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29825965
41MYC_18940864_ChIP-ChIP_HL60_Human1.28581530
42RNF2_27304074_Chip-Seq_NSC_Mouse1.27946224
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26904657
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25716866
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25368656
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24709063
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23351572
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21359944
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.21359944
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.21290904
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.20047361
52P300_19829295_ChIP-Seq_ESCs_Human1.19410567
53ERA_21632823_ChIP-Seq_H3396_Human1.19123780
54* NCOR_22424771_ChIP-Seq_293T_Human1.18629889
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.17529962
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15819450
57CBP_20019798_ChIP-Seq_JUKART_Human1.12783207
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12783207
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12379565
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12052043
61TAF2_19829295_ChIP-Seq_ESCs_Human1.10861650
62NANOG_20526341_ChIP-Seq_ESCs_Human1.09112084
63BCAT_22108803_ChIP-Seq_LS180_Human1.08905231
64TAF15_26573619_Chip-Seq_HEK293_Human1.08160715
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.05843060
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05545860
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05408104
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04870737
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.03926192
70* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03532886
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03524740
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03524740
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02858850
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02546893
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02522474
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02176211
77AR_25329375_ChIP-Seq_VCAP_Human1.01476042
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.01230477
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01102826
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99805443
81SOX2_19829295_ChIP-Seq_ESCs_Human0.98279190
82NANOG_19829295_ChIP-Seq_ESCs_Human0.98279190
83AR_20517297_ChIP-Seq_VCAP_Human0.98248620
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98081687
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97109059
86DROSHA_22980978_ChIP-Seq_HELA_Human0.96837958
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96769419
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96447411
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95800796
90* MYC_19829295_ChIP-Seq_ESCs_Human0.95580103
91* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95152340
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94975298
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94700950
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92949597
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.92629478
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92246384
97HOXB7_26014856_ChIP-Seq_BT474_Human0.91959740
98TCF4_23295773_ChIP-Seq_U87_Human0.91051608
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90569768
100SMAD4_21799915_ChIP-Seq_A2780_Human0.88369212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland2.90592037
2MP0006292_abnormal_olfactory_placode2.76422272
3MP0002138_abnormal_hepatobiliary_system2.62514411
4MP0004885_abnormal_endolymph2.40587577
5MP0001968_abnormal_touch/_nociception2.36416422
6MP0003646_muscle_fatigue2.35312269
7MP0002876_abnormal_thyroid_physiology2.30188749
8MP0002837_dystrophic_cardiac_calcinosis2.29114743
9MP0002160_abnormal_reproductive_system2.18732322
10MP0002102_abnormal_ear_morphology2.15185613
11MP0008872_abnormal_physiological_respon2.11902554
12MP0001485_abnormal_pinna_reflex1.97013550
13MP0002653_abnormal_ependyma_morphology1.96159221
14MP0000049_abnormal_middle_ear1.95101871
15MP0005551_abnormal_eye_electrophysiolog1.89404627
16MP0008877_abnormal_DNA_methylation1.87216944
17MP0001986_abnormal_taste_sensitivity1.85477946
18MP0004145_abnormal_muscle_electrophysio1.84145016
19MP0000631_abnormal_neuroendocrine_gland1.84035200
20MP0003195_calcinosis1.80290339
21MP0005389_reproductive_system_phenotype1.80060019
22MP0005671_abnormal_response_to1.79332840
23MP0003724_increased_susceptibility_to1.68121430
24MP0002736_abnormal_nociception_after1.67589227
25MP0002272_abnormal_nervous_system1.65441904
26MP0002638_abnormal_pupillary_reflex1.63399532
27MP0004142_abnormal_muscle_tone1.61770466
28MP0009745_abnormal_behavioral_response1.60066198
29MP0004130_abnormal_muscle_cell1.54108757
30MP0002735_abnormal_chemical_nociception1.52135573
31MP0008875_abnormal_xenobiotic_pharmacok1.49571118
32MP0005083_abnormal_biliary_tract1.49537127
33MP0006072_abnormal_retinal_apoptosis1.48672243
34MP0004133_heterotaxia1.44611147
35MP0005645_abnormal_hypothalamus_physiol1.44293373
36MP0003283_abnormal_digestive_organ1.43679491
37MP0003879_abnormal_hair_cell1.41068203
38MP0003011_delayed_dark_adaptation1.37259286
39MP0000678_abnormal_parathyroid_gland1.36097588
40MP0005084_abnormal_gallbladder_morpholo1.32757229
41MP0002163_abnormal_gland_morphology1.30038591
42MP0001905_abnormal_dopamine_level1.27825896
43MP0009046_muscle_twitch1.26468752
44MP0002277_abnormal_respiratory_mucosa1.25445913
45MP0000372_irregular_coat_pigmentation1.25328055
46MP0002733_abnormal_thermal_nociception1.22581059
47MP0001970_abnormal_pain_threshold1.21655703
48MP0001919_abnormal_reproductive_system1.18344214
49MP0003938_abnormal_ear_development1.17557702
50MP0003787_abnormal_imprinting1.14934849
51MP0002064_seizures1.14798627
52MP0001440_abnormal_grooming_behavior1.14190041
53MP0006276_abnormal_autonomic_nervous1.13812105
54MP0005253_abnormal_eye_physiology1.13131309
55MP0002928_abnormal_bile_duct1.11120062
56MP0008789_abnormal_olfactory_epithelium1.11064305
57MP0005410_abnormal_fertilization1.09134411
58MP0003638_abnormal_response/metabolism_1.08936496
59MP0005174_abnormal_tail_pigmentation1.06790913
60MP0001963_abnormal_hearing_physiology1.04140224
61MP0000026_abnormal_inner_ear1.03301413
62MP0004134_abnormal_chest_morphology1.01823263
63MP0001486_abnormal_startle_reflex1.00472036
64MP0000230_abnormal_systemic_arterial0.99687078
65MP0005670_abnormal_white_adipose0.97265212
66MP0003880_abnormal_central_pattern0.95464079
67MP0002572_abnormal_emotion/affect_behav0.95152052
68MP0003119_abnormal_digestive_system0.95056841
69MP0003635_abnormal_synaptic_transmissio0.91580913
70MP0001502_abnormal_circadian_rhythm0.90876315
71MP0010386_abnormal_urinary_bladder0.90395749
72MP0001765_abnormal_ion_homeostasis0.89466961
73MP0002734_abnormal_mechanical_nocicepti0.88170187
74MP0004742_abnormal_vestibular_system0.87419802
75MP0009250_abnormal_appendicular_skeleto0.85777782
76MP0000613_abnormal_salivary_gland0.85710535
77MP0001800_abnormal_humoral_immune0.85092276
78MP0001873_stomach_inflammation0.84426893
79MP0005195_abnormal_posterior_eye0.84107997
80MP0002557_abnormal_social/conspecific_i0.83717581
81MP0005379_endocrine/exocrine_gland_phen0.82903073
82MP0002148_abnormal_hypersensitivity_rea0.82679442
83MP0009764_decreased_sensitivity_to0.81686235
84MP0005360_urolithiasis0.80710230
85MP0002063_abnormal_learning/memory/cond0.80066261
86MP0005171_absent_coat_pigmentation0.78992341
87MP0005423_abnormal_somatic_nervous0.76909830
88MP0001501_abnormal_sleep_pattern0.76723833
89MP0009785_altered_susceptibility_to0.74966332
90MP0004043_abnormal_pH_regulation0.74930066
91MP0009384_cardiac_valve_regurgitation0.74827706
92MP0002752_abnormal_somatic_nervous0.74060412
93MP0002249_abnormal_larynx_morphology0.72695952
94MP0000013_abnormal_adipose_tissue0.70624479
95MP0000685_abnormal_immune_system0.70248861
96MP0009765_abnormal_xenobiotic_induced0.69368681
97MP0008775_abnormal_heart_ventricle0.68305609
98MP0000681_abnormal_thyroid_gland0.67322991
99MP0003252_abnormal_bile_duct0.65684034
100MP0002132_abnormal_respiratory_system0.65392763

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.70374698
2Pancreatic cysts (HP:0001737)3.68430894
3Pendular nystagmus (HP:0012043)3.60806755
4Abolished electroretinogram (ERG) (HP:0000550)3.38978497
5Pancreatic fibrosis (HP:0100732)3.34514185
6Abnormality of the renal collecting system (HP:0004742)3.29105973
7True hermaphroditism (HP:0010459)3.21604559
8Nephronophthisis (HP:0000090)3.17411858
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11941236
10Abnormal rod and cone electroretinograms (HP:0008323)3.04598380
11Molar tooth sign on MRI (HP:0002419)3.02611095
12Abnormality of midbrain morphology (HP:0002418)3.02611095
13Absent/shortened dynein arms (HP:0200106)2.94320792
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.94320792
15Decreased central vision (HP:0007663)2.84760370
16Stenosis of the external auditory canal (HP:0000402)2.84210210
17Attenuation of retinal blood vessels (HP:0007843)2.84077072
18Abnormal respiratory epithelium morphology (HP:0012253)2.75312655
19Abnormal respiratory motile cilium morphology (HP:0005938)2.75312655
20Methylmalonic acidemia (HP:0002912)2.71655021
21Abnormality of the renal cortex (HP:0011035)2.70490797
22Asplenia (HP:0001746)2.69566219
23Increased corneal curvature (HP:0100692)2.66488764
24Keratoconus (HP:0000563)2.66488764
25Morphological abnormality of the middle ear (HP:0008609)2.65607441
26Short 1st metacarpal (HP:0010034)2.64917559
27Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.64917559
283-Methylglutaconic aciduria (HP:0003535)2.62497242
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59971001
30Abnormality of the renal medulla (HP:0100957)2.59457543
31Aplasia/Hypoplasia of the spleen (HP:0010451)2.58048921
32Congenital, generalized hypertrichosis (HP:0004540)2.53189541
33Congenital sensorineural hearing impairment (HP:0008527)2.49426592
34Mitochondrial inheritance (HP:0001427)2.46904957
35Abnormal ciliary motility (HP:0012262)2.42792139
36Methylmalonic aciduria (HP:0012120)2.39675395
37Absent thumb (HP:0009777)2.38093480
38Chorioretinal atrophy (HP:0000533)2.35026215
39Genetic anticipation (HP:0003743)2.33723896
40Type II lissencephaly (HP:0007260)2.33535077
41IgG deficiency (HP:0004315)2.33050106
42Abnormality of the 1st metacarpal (HP:0010009)2.32348995
43Abnormality of the proximal phalanges of the hand (HP:0009834)2.28173630
44Short phalanx of the thumb (HP:0009660)2.25831645
45Bony spicule pigmentary retinopathy (HP:0007737)2.25458336
46Acute necrotizing encephalopathy (HP:0006965)2.24510955
47Cystic liver disease (HP:0006706)2.23714473
48Progressive cerebellar ataxia (HP:0002073)2.23076030
49Medial flaring of the eyebrow (HP:0010747)2.18354014
50Abnormal drinking behavior (HP:0030082)2.17565646
51Polydipsia (HP:0001959)2.17565646
52Severe visual impairment (HP:0001141)2.17356399
53Decreased circulating renin level (HP:0003351)2.16269225
54Abnormality of the nasal septum (HP:0000419)2.15016485
55Increased CSF lactate (HP:0002490)2.13863238
56Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.13424626
57Hepatocellular necrosis (HP:0001404)2.11831937
58Renal cortical cysts (HP:0000803)2.11589256
59Agitation (HP:0000713)2.10642384
60Hypoplasia of the uterus (HP:0000013)2.09146912
61Abnormal mitochondria in muscle tissue (HP:0008316)2.08653831
62Abnormal respiratory motile cilium physiology (HP:0012261)2.08273066
63Clumsiness (HP:0002312)2.07636892
64Tubular atrophy (HP:0000092)2.05454172
65Sclerocornea (HP:0000647)2.02398580
66Concave nail (HP:0001598)2.00624861
67Aplasia/hypoplasia of the uterus (HP:0008684)1.96492548
68Abnormality of DNA repair (HP:0003254)1.96392330
69Short hallux (HP:0010109)1.94537077
70Progressive macrocephaly (HP:0004481)1.94160916
71Abnormality of the phalanges of the 5th finger (HP:0004213)1.94147661
72Abnormality of the middle phalanges of the toes (HP:0010183)1.93229843
73Aplasia/Hypoplasia of the hallux (HP:0008362)1.92978492
74Abnormality of alanine metabolism (HP:0010916)1.92417955
75Hyperalaninemia (HP:0003348)1.92417955
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92417955
77Furrowed tongue (HP:0000221)1.90724101
78Symphalangism affecting the phalanges of the hand (HP:0009773)1.90134132
79Short femoral neck (HP:0100864)1.88345569
80Thyroid-stimulating hormone excess (HP:0002925)1.86972432
81Abnormality of cochlea (HP:0000375)1.85853379
82Male pseudohermaphroditism (HP:0000037)1.85123313
83Hepatic necrosis (HP:0002605)1.82915684
84Goiter (HP:0000853)1.81394555
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.80372685
86Acute encephalopathy (HP:0006846)1.78740765
87Severe muscular hypotonia (HP:0006829)1.78551180
88Chronic sinusitis (HP:0011109)1.78535108
89Hypothermia (HP:0002045)1.77246155
90Lipid accumulation in hepatocytes (HP:0006561)1.76781761
91Congenital hepatic fibrosis (HP:0002612)1.75797765
92Gaze-evoked nystagmus (HP:0000640)1.75601840
93Thyroiditis (HP:0100646)1.75504014
94Porencephaly (HP:0002132)1.73046967
95Small hand (HP:0200055)1.72817215
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71792846
97Tachypnea (HP:0002789)1.71772093
98Anencephaly (HP:0002323)1.70178453
99Optic disc pallor (HP:0000543)1.69932467
100Chronic hepatic failure (HP:0100626)1.68818960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.81869132
2FRK3.90797512
3ADRBK23.87730618
4GRK13.65484721
5TAOK33.12661305
6ZAK2.44180953
7TXK2.42959698
8MAP4K22.41400776
9PINK12.27911458
10BMPR1B2.26226152
11BCKDK1.92075271
12MAPK131.81135126
13NUAK11.79556873
14WNK41.65255466
15ACVR1B1.60430934
16MAPK151.52507166
17WNK31.40944082
18INSRR1.37266589
19IKBKB1.37254085
20GRK61.35208005
21KIT1.33130059
22MAP3K41.31861535
23MUSK1.27071355
24DAPK21.19235459
25MAP2K71.16205693
26VRK11.16001707
27ADRBK11.13045860
28PHKG11.10876152
29PHKG21.10876152
30MAP2K61.10738570
31DYRK21.07956054
32GRK71.05298336
33MAPKAPK31.05268054
34MAP2K21.04217610
35STK161.03267670
36MAP4K11.02787607
37TIE11.01671254
38OXSR11.01555995
39PRKCG1.00284742
40PRKD20.96882597
41TEC0.94409139
42SYK0.94082083
43RPS6KA50.92875129
44CASK0.91329283
45ITK0.88890947
46PTK2B0.88168651
47PRKCQ0.86836383
48CSNK1G30.85493194
49EPHA30.83037251
50CSNK1G20.83036641
51PRKCI0.82636258
52GRK50.81059037
53VRK20.80839964
54STK390.79672452
55PRKCE0.75095494
56CAMKK20.74505362
57PKN10.74490884
58PIK3CA0.73750150
59CSNK1G10.68345250
60RPS6KA60.67106676
61CSNK1A1L0.65359346
62LYN0.64005890
63PRKACA0.63854522
64SIK20.60974866
65KDR0.59694145
66FES0.58609974
67IKBKE0.57614549
68TNK20.55532561
69CSNK1A10.55257373
70OBSCN0.54032242
71MAPKAPK50.53305903
72NTRK20.53129516
73MAP2K10.52621291
74AURKA0.52461744
75LCK0.51022182
76BTK0.50305133
77MAP2K40.49957414
78CAMK2A0.49608496
79PRKCZ0.48441361
80NME10.48123116
81PRKCA0.47642207
82CAMK10.46239334
83PIM10.45325574
84HIPK20.44942371
85PAK30.44899828
86PRKCH0.44212224
87MARK10.44098692
88ABL20.43389595
89NTRK30.42554112
90CHUK0.41158390
91MAP3K110.41052254
92BLK0.40826332
93STK110.40814219
94PLK20.40466435
95SGK20.39819696
96SGK4940.38483544
97SGK2230.38483544
98ABL10.37597716
99IGF1R0.36143507
100RPS6KA20.35740789

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84699685
2Oxidative phosphorylation_Homo sapiens_hsa001902.53985406
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51368752
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.46346956
5Phototransduction_Homo sapiens_hsa047442.45115480
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32516298
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.10642338
8Nicotine addiction_Homo sapiens_hsa050332.07843284
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.07594579
10Linoleic acid metabolism_Homo sapiens_hsa005912.07192208
11Primary immunodeficiency_Homo sapiens_hsa053402.03938208
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93675836
13Parkinsons disease_Homo sapiens_hsa050121.91495869
14Asthma_Homo sapiens_hsa053101.88763586
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87301430
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81904697
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79076387
18Sulfur metabolism_Homo sapiens_hsa009201.65749734
19Sulfur relay system_Homo sapiens_hsa041221.64348057
20Graft-versus-host disease_Homo sapiens_hsa053321.62075858
21Selenocompound metabolism_Homo sapiens_hsa004501.55427999
22Nitrogen metabolism_Homo sapiens_hsa009101.54177398
23Chemical carcinogenesis_Homo sapiens_hsa052041.53802685
24Systemic lupus erythematosus_Homo sapiens_hsa053221.49441982
25Allograft rejection_Homo sapiens_hsa053301.48092398
26Tryptophan metabolism_Homo sapiens_hsa003801.46256872
27Autoimmune thyroid disease_Homo sapiens_hsa053201.43383872
28Homologous recombination_Homo sapiens_hsa034401.43090870
29Alzheimers disease_Homo sapiens_hsa050101.40639504
30Morphine addiction_Homo sapiens_hsa050321.40141271
31Type I diabetes mellitus_Homo sapiens_hsa049401.38731980
32Caffeine metabolism_Homo sapiens_hsa002321.34257891
33Cardiac muscle contraction_Homo sapiens_hsa042601.33009975
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30607433
35RNA polymerase_Homo sapiens_hsa030201.29707027
36Ribosome_Homo sapiens_hsa030101.29478808
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27743474
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26221309
39Taste transduction_Homo sapiens_hsa047421.25871643
40Huntingtons disease_Homo sapiens_hsa050161.24351310
41Olfactory transduction_Homo sapiens_hsa047401.22905262
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22334871
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.16006517
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11532873
45Retinol metabolism_Homo sapiens_hsa008301.11096183
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08188328
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05281853
48Ether lipid metabolism_Homo sapiens_hsa005651.03299174
49Fanconi anemia pathway_Homo sapiens_hsa034601.02358937
50Arachidonic acid metabolism_Homo sapiens_hsa005900.99393373
51Protein export_Homo sapiens_hsa030600.96723492
52Collecting duct acid secretion_Homo sapiens_hsa049660.93170837
53Insulin secretion_Homo sapiens_hsa049110.90441528
54Rheumatoid arthritis_Homo sapiens_hsa053230.90221080
55Circadian entrainment_Homo sapiens_hsa047130.89019913
56RNA degradation_Homo sapiens_hsa030180.88010609
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87835939
58Peroxisome_Homo sapiens_hsa041460.87635369
59Glycerolipid metabolism_Homo sapiens_hsa005610.85253071
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84412929
61Regulation of autophagy_Homo sapiens_hsa041400.82123833
62GABAergic synapse_Homo sapiens_hsa047270.81862417
63Basal transcription factors_Homo sapiens_hsa030220.79445848
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79007554
65Serotonergic synapse_Homo sapiens_hsa047260.76483822
66Butanoate metabolism_Homo sapiens_hsa006500.75346406
67Calcium signaling pathway_Homo sapiens_hsa040200.74753680
68Vitamin digestion and absorption_Homo sapiens_hsa049770.72969154
69Hematopoietic cell lineage_Homo sapiens_hsa046400.71904935
70Salivary secretion_Homo sapiens_hsa049700.70113951
71Alcoholism_Homo sapiens_hsa050340.68257274
72Glutamatergic synapse_Homo sapiens_hsa047240.68055374
73Renin secretion_Homo sapiens_hsa049240.67221089
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64503721
75Fat digestion and absorption_Homo sapiens_hsa049750.63519247
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58802449
77ABC transporters_Homo sapiens_hsa020100.56323668
78Ovarian steroidogenesis_Homo sapiens_hsa049130.56172070
79Antigen processing and presentation_Homo sapiens_hsa046120.54516788
80Dorso-ventral axis formation_Homo sapiens_hsa043200.51400265
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46396809
82Cholinergic synapse_Homo sapiens_hsa047250.44555772
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.42408679
84Purine metabolism_Homo sapiens_hsa002300.42140209
85Metabolic pathways_Homo sapiens_hsa011000.41930633
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41446904
87cAMP signaling pathway_Homo sapiens_hsa040240.41273739
88Renin-angiotensin system_Homo sapiens_hsa046140.40208639
89beta-Alanine metabolism_Homo sapiens_hsa004100.39019512
90Pyrimidine metabolism_Homo sapiens_hsa002400.38840261
91Dopaminergic synapse_Homo sapiens_hsa047280.38397755
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.38190309
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37721839
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37592689
95Mineral absorption_Homo sapiens_hsa049780.37448588
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36485342
97Histidine metabolism_Homo sapiens_hsa003400.35493046
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33809367
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33722236
100Staphylococcus aureus infection_Homo sapiens_hsa051500.30106417

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