ZNF683

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.55947074
2negative regulation of cell killing (GO:0031342)7.44740644
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.44740644
4sperm motility (GO:0030317)5.86025310
5fusion of sperm to egg plasma membrane (GO:0007342)5.81816626
6acrosome reaction (GO:0007340)5.74062321
7activated T cell proliferation (GO:0050798)5.30641380
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08857386
9positive regulation of gamma-delta T cell activation (GO:0046645)5.06948919
10regulation of natural killer cell mediated immunity (GO:0002715)4.89705083
11regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.89705083
12regulation of T cell mediated cytotoxicity (GO:0001914)4.86422289
13positive regulation of T cell mediated cytotoxicity (GO:0001916)4.83452162
14response to pheromone (GO:0019236)4.82403359
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.81367949
16positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.79636851
17cellular response to interleukin-15 (GO:0071350)4.75843456
18regulation of leukocyte mediated cytotoxicity (GO:0001910)4.75334386
19regulation of gamma-delta T cell differentiation (GO:0045586)4.71700715
20antigen processing and presentation of endogenous antigen (GO:0019883)4.66911924
21positive thymic T cell selection (GO:0045059)4.62596111
22positive regulation of natural killer cell mediated immunity (GO:0002717)4.62525020
23negative T cell selection (GO:0043383)4.60607379
24positive T cell selection (GO:0043368)4.60368782
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54337691
26response to interleukin-15 (GO:0070672)4.44570000
27regulation of gamma-delta T cell activation (GO:0046643)4.41561200
28regulation of B cell receptor signaling pathway (GO:0050855)4.40052492
29RNA destabilization (GO:0050779)4.39631371
30mast cell activation (GO:0045576)4.32295967
31positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.30936219
32plasma membrane fusion (GO:0045026)4.30442477
33sperm capacitation (GO:0048240)4.28409567
34regulation of cell killing (GO:0031341)4.27523570
35positive regulation of cell killing (GO:0031343)4.27520855
36mast cell activation involved in immune response (GO:0002279)4.24499406
37mast cell degranulation (GO:0043303)4.24499406
38negative thymic T cell selection (GO:0045060)4.23650114
39phosphatidylethanolamine biosynthetic process (GO:0006646)3.98530871
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.87752713
41spermatid development (GO:0007286)3.83581423
42NIK/NF-kappaB signaling (GO:0038061)3.80056302
43multicellular organism reproduction (GO:0032504)3.79262385
44phosphatidylethanolamine metabolic process (GO:0046337)3.69358944
45leukocyte aggregation (GO:0070486)3.65569987
46single strand break repair (GO:0000012)3.62827652
47antigen processing and presentation via MHC class Ib (GO:0002475)3.60347328
48spermatid nucleus differentiation (GO:0007289)3.60002933
49protein targeting to Golgi (GO:0000042)3.56277543
50regulation of T cell tolerance induction (GO:0002664)3.52683599
51respiratory burst (GO:0045730)3.48638145
52thymic T cell selection (GO:0045061)3.46717677
53establishment of protein localization to Golgi (GO:0072600)3.46088051
54reproduction (GO:0000003)3.45439351
55T cell selection (GO:0045058)3.43105787
56positive regulation of granulocyte differentiation (GO:0030854)3.42166309
57T cell migration (GO:0072678)3.41297561
58negative regulation of innate immune response (GO:0045824)3.39941165
59regulation of regulatory T cell differentiation (GO:0045589)3.39843290
60leukocyte degranulation (GO:0043299)3.38654843
61cytidine metabolic process (GO:0046087)3.36156202
62cytidine catabolic process (GO:0006216)3.36156202
63cytidine deamination (GO:0009972)3.36156202
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34692329
65type I interferon signaling pathway (GO:0060337)3.32445992
66cellular response to type I interferon (GO:0071357)3.32445992
67negative regulation of leukocyte mediated immunity (GO:0002704)3.31680460
68negative regulation of T cell mediated immunity (GO:0002710)3.31267193
69rRNA methylation (GO:0031167)3.30821637
70response to type I interferon (GO:0034340)3.30583722
71positive regulation of tolerance induction (GO:0002645)3.27707936
72T cell receptor signaling pathway (GO:0050852)3.27639563
73positive regulation of T cell mediated immunity (GO:0002711)3.25729025
74pyrimidine ribonucleoside catabolic process (GO:0046133)3.23853893
75microtubule depolymerization (GO:0007019)3.23500098
76regulation of alpha-beta T cell proliferation (GO:0046640)3.21964758
77regulation of T cell mediated immunity (GO:0002709)3.19096502
78retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17606500
79chromosome condensation (GO:0030261)3.13162725
80response to interferon-beta (GO:0035456)3.12470239
81DNA packaging (GO:0006323)3.12157343
82positive regulation of interleukin-4 production (GO:0032753)3.08921906
83regulation of tolerance induction (GO:0002643)3.08389847
84DNA deamination (GO:0045006)3.08384888
85positive regulation of lymphocyte mediated immunity (GO:0002708)3.08252045
86sperm-egg recognition (GO:0035036)3.08079484
87myeloid cell activation involved in immune response (GO:0002275)3.07997206
88protein polyglutamylation (GO:0018095)3.06402417
89antigen receptor-mediated signaling pathway (GO:0050851)3.03635529
90coenzyme catabolic process (GO:0009109)3.03462744
91cilium or flagellum-dependent cell motility (GO:0001539)3.02174595
92cellular ketone body metabolic process (GO:0046950)2.99337172
93regulation of Rab GTPase activity (GO:0032313)2.99207205
94positive regulation of Rab GTPase activity (GO:0032851)2.99207205
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97504119
96cellular extravasation (GO:0045123)2.94418946
97regulation of lymphocyte mediated immunity (GO:0002706)2.92138754
98calcium ion-dependent exocytosis (GO:0017156)2.92083346
99positive regulation of interleukin-8 secretion (GO:2000484)2.90693818
100cellular defense response (GO:0006968)2.87528637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.33499525
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.25496799
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10800124
4* RUNX_20019798_ChIP-Seq_JUKART_Human3.23164492
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.20367219
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.88113928
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.75901938
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73753853
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45197811
10MYB_26560356_Chip-Seq_TH2_Human2.44430642
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30676427
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08006344
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02144306
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01931330
15* GATA3_27048872_Chip-Seq_THYMUS_Human1.90464316
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.90104805
17VDR_22108803_ChIP-Seq_LS180_Human1.87733450
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85257198
19* BCL6_27268052_Chip-Seq_Bcells_Human1.82645886
20GATA3_26560356_Chip-Seq_TH2_Human1.74896309
21MYB_26560356_Chip-Seq_TH1_Human1.74078087
22* UTX_26944678_Chip-Seq_JUKART_Human1.71521842
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64061536
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.63964734
25DROSHA_22980978_ChIP-Seq_HELA_Human1.62675885
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57912415
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57560550
28* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57119691
29* ERA_21632823_ChIP-Seq_H3396_Human1.56669577
30* NANOG_20526341_ChIP-Seq_ESCs_Human1.56488520
31MAF_26560356_Chip-Seq_TH2_Human1.55539552
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.55191293
33MAF_26560356_Chip-Seq_TH1_Human1.54253588
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.52802858
35* BCOR_27268052_Chip-Seq_Bcells_Human1.50265390
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49697149
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49064534
38RAC3_21632823_ChIP-Seq_H3396_Human1.45904373
39SPI1_23127762_ChIP-Seq_K562_Human1.45016070
40EZH2_22144423_ChIP-Seq_EOC_Human1.41980492
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40757252
42SMRT_27268052_Chip-Seq_Bcells_Human1.34351280
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.33706988
44ER_23166858_ChIP-Seq_MCF-7_Human1.32922574
45TAF2_19829295_ChIP-Seq_ESCs_Human1.32620262
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32008493
47* P300_27268052_Chip-Seq_Bcells_Human1.31652585
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30716393
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30716393
50* E2F1_20622854_ChIP-Seq_HELA_Human1.30242601
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29143540
52SCL_19346495_ChIP-Seq_HPC-7_Human1.28854796
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.28541970
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.23719367
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23560360
56TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22125593
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21469405
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.21263663
59ZNF274_21170338_ChIP-Seq_K562_Hela1.21177784
60* OCT4_20526341_ChIP-Seq_ESCs_Human1.20566089
61CBP_20019798_ChIP-Seq_JUKART_Human1.19443077
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19443077
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18887571
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18710523
65P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16647449
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16601780
67SPI1_23547873_ChIP-Seq_NB4_Human1.16302230
68CEBPB_22108803_ChIP-Seq_LS180_Human1.16018409
69VDR_24787735_ChIP-Seq_THP-1_Human1.15550975
70PHF8_20622854_ChIP-Seq_HELA_Human1.13674299
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11566659
72RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11203596
73* SA1_27219007_Chip-Seq_Bcells_Human1.10129015
74MYC_19829295_ChIP-Seq_ESCs_Human1.09545920
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08752039
76GATA3_26560356_Chip-Seq_TH1_Human1.08127509
77TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06988988
78SPI1_20517297_ChIP-Seq_HL60_Human1.06297145
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06249129
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05549181
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05026590
82* P68_20966046_ChIP-Seq_HELA_Human1.02509017
83* CTCF_20526341_ChIP-Seq_ESCs_Human1.01989852
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00798812
85SMC4_20622854_ChIP-Seq_HELA_Human0.98873678
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98130000
87ERG_20517297_ChIP-Seq_VCAP_Human0.97857856
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96622757
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96267282
90KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96176115
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95791315
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95306269
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94989110
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93954225
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91918343
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.91866715
97* GATA6_21074721_ChIP-Seq_CACO-2_Human0.91214096
98* TP63_22573176_ChIP-Seq_HFKS_Human0.91145600
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.89876482
100* RBPJ_21746931_ChIP-Seq_IB4_Human0.89799902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.40123481
2MP0005671_abnormal_response_to4.74315797
3MP0001835_abnormal_antigen_presentation3.21973141
4MP0001800_abnormal_humoral_immune2.82329888
5MP0009785_altered_susceptibility_to2.75509415
6MP0003436_decreased_susceptibility_to2.75372989
7MP0003878_abnormal_ear_physiology2.72131629
8MP0005377_hearing/vestibular/ear_phenot2.72131629
9MP0003763_abnormal_thymus_physiology2.64314318
10MP0005000_abnormal_immune_tolerance2.60696839
11MP0002723_abnormal_immune_serum2.54357346
12MP0005025_abnormal_response_to2.53037722
13MP0005387_immune_system_phenotype2.49542501
14MP0001790_abnormal_immune_system2.49542501
15MP0003724_increased_susceptibility_to2.44507836
16MP0002132_abnormal_respiratory_system2.41567040
17MP0002420_abnormal_adaptive_immunity2.36406323
18MP0001819_abnormal_immune_cell2.31544551
19MP0001348_abnormal_lacrimal_gland2.30283302
20MP0002452_abnormal_antigen_presenting2.20009423
21MP0006082_CNS_inflammation2.09286110
22MP0002419_abnormal_innate_immunity2.08076789
23MP0000685_abnormal_immune_system2.06528195
24MP0003698_abnormal_male_reproductive1.99656407
25MP0002148_abnormal_hypersensitivity_rea1.89244710
26MP0003787_abnormal_imprinting1.87419144
27MP0002405_respiratory_system_inflammati1.85994816
28MP0002398_abnormal_bone_marrow1.77603179
29MP0000716_abnormal_immune_system1.76569489
30MP0001929_abnormal_gametogenesis1.73380832
31MP0000703_abnormal_thymus_morphology1.72411243
32MP0009333_abnormal_splenocyte_physiolog1.68663135
33MP0008877_abnormal_DNA_methylation1.58997565
34MP0005670_abnormal_white_adipose1.58818045
35MP0001501_abnormal_sleep_pattern1.58056513
36MP0005075_abnormal_melanosome_morpholog1.55469243
37MP0003866_abnormal_defecation1.54285036
38MP0002166_altered_tumor_susceptibility1.51893875
39MP0000015_abnormal_ear_pigmentation1.50826263
40MP0000689_abnormal_spleen_morphology1.46865762
41MP0002722_abnormal_immune_system1.45730242
42MP0005379_endocrine/exocrine_gland_phen1.44482574
43MP0002277_abnormal_respiratory_mucosa1.43577771
44MP0001533_abnormal_skeleton_physiology1.42666442
45MP0003011_delayed_dark_adaptation1.42173759
46MP0002933_joint_inflammation1.39974587
47MP0001845_abnormal_inflammatory_respons1.37501506
48MP0005464_abnormal_platelet_physiology1.35445279
49MP0002102_abnormal_ear_morphology1.31344414
50MP0002429_abnormal_blood_cell1.28822559
51MP0005083_abnormal_biliary_tract1.28076508
52MP0004381_abnormal_hair_follicle1.24640994
53MP0001873_stomach_inflammation1.21805983
54MP0008469_abnormal_protein_level1.20119138
55MP0005310_abnormal_salivary_gland1.17517824
56MP0002138_abnormal_hepatobiliary_system1.16097919
57MP0009764_decreased_sensitivity_to1.14954574
58MP0010155_abnormal_intestine_physiology1.12718292
59MP0003172_abnormal_lysosome_physiology1.11175768
60MP0002006_tumorigenesis1.05353420
61MP0000569_abnormal_digit_pigmentation1.05005270
62MP0001765_abnormal_ion_homeostasis0.98984115
63MP0001968_abnormal_touch/_nociception0.97891649
64MP0002161_abnormal_fertility/fecundity0.96097645
65MP0004742_abnormal_vestibular_system0.92284840
66MP0002693_abnormal_pancreas_physiology0.90320884
67MP0006276_abnormal_autonomic_nervous0.85478053
68MP0004947_skin_inflammation0.80102216
69MP0003300_gastrointestinal_ulcer0.77031597
70MP0002210_abnormal_sex_determination0.76988733
71MP0003646_muscle_fatigue0.76230386
72MP0005645_abnormal_hypothalamus_physiol0.74508362
73MP0002998_abnormal_bone_remodeling0.73336074
74MP0004883_abnormal_blood_vessel0.72982015
75MP0001905_abnormal_dopamine_level0.69777999
76MP0002909_abnormal_adrenal_gland0.69620005
77MP0005084_abnormal_gallbladder_morpholo0.68485251
78MP0000230_abnormal_systemic_arterial0.67161249
79MP0003303_peritoneal_inflammation0.66962704
80MP0008872_abnormal_physiological_respon0.65762436
81MP0001485_abnormal_pinna_reflex0.65482833
82MP0005365_abnormal_bile_salt0.64901846
83MP0008961_abnormal_basal_metabolism0.63319680
84MP0002095_abnormal_skin_pigmentation0.61523698
85MP0002136_abnormal_kidney_physiology0.60615073
86MP0008569_lethality_at_weaning0.58726774
87MP0000653_abnormal_sex_gland0.57136298
88MP0005174_abnormal_tail_pigmentation0.56306264
89MP0005535_abnormal_body_temperature0.55262418
90MP0001145_abnormal_male_reproductive0.54977475
91MP0001486_abnormal_startle_reflex0.54592886
92MP0002736_abnormal_nociception_after0.53204098
93MP0004510_myositis0.52840222
94MP0002653_abnormal_ependyma_morphology0.52778183
95MP0005551_abnormal_eye_electrophysiolog0.52434078
96MP0003183_abnormal_peptide_metabolism0.52274117
97MP0005167_abnormal_blood-brain_barrier0.52157641
98MP0008874_decreased_physiological_sensi0.51763735
99MP0005636_abnormal_mineral_homeostasis0.51672650
100MP0005248_abnormal_Harderian_gland0.51573151

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.68889438
2Elevated erythrocyte sedimentation rate (HP:0003565)4.83454882
3T lymphocytopenia (HP:0005403)4.48425878
4Myositis (HP:0100614)4.23916374
5Abnormality of T cell number (HP:0011839)4.06414326
6Recurrent bacterial skin infections (HP:0005406)3.94297775
7Absent/shortened dynein arms (HP:0200106)3.84273070
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.84273070
9Recurrent abscess formation (HP:0002722)3.67402273
10Abnormal rod and cone electroretinograms (HP:0008323)3.54526811
11Stomatitis (HP:0010280)3.52049269
12Attenuation of retinal blood vessels (HP:0007843)3.46017569
13Hypochromic microcytic anemia (HP:0004840)3.43387448
14Nasal polyposis (HP:0100582)3.42960655
15Severe combined immunodeficiency (HP:0004430)3.37183846
16Retrobulbar optic neuritis (HP:0100654)3.34310999
17Optic neuritis (HP:0100653)3.34310999
18Abnormality of T cells (HP:0002843)3.30054046
19Keratoconjunctivitis sicca (HP:0001097)3.29401342
20Encephalitis (HP:0002383)3.26605880
21Orchitis (HP:0100796)3.19243542
22Abnormality of macrophages (HP:0004311)3.17842515
23Keratoconjunctivitis (HP:0001096)3.16873235
24IgG deficiency (HP:0004315)3.11482745
25Gastrointestinal infarctions (HP:0005244)3.11462473
26Recurrent skin infections (HP:0001581)3.07262049
27Pustule (HP:0200039)3.02766761
28Slow saccadic eye movements (HP:0000514)2.99961188
29Eczematoid dermatitis (HP:0000976)2.93857499
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91009294
31Spastic paraparesis (HP:0002313)2.86233018
32Meningitis (HP:0001287)2.79866485
33Sensory axonal neuropathy (HP:0003390)2.77554401
34Hypoplasia of the thymus (HP:0000778)2.72142509
35Abnormality of the nasal mucosa (HP:0000433)2.71911953
36Hypochromic anemia (HP:0001931)2.65868776
37Abnormal ciliary motility (HP:0012262)2.64072973
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.63772520
39Abnormal respiratory motile cilium morphology (HP:0005938)2.58816039
40Abnormal respiratory epithelium morphology (HP:0012253)2.58816039
41Chronic hepatic failure (HP:0100626)2.58732580
42Recurrent fungal infections (HP:0002841)2.58610272
43Chronic obstructive pulmonary disease (HP:0006510)2.58220854
44Obstructive lung disease (HP:0006536)2.58220854
45Inflammation of the large intestine (HP:0002037)2.56642919
46Increased IgM level (HP:0003496)2.55130014
47Abnormal respiratory motile cilium physiology (HP:0012261)2.54041547
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49117106
49Leukocytosis (HP:0001974)2.47906918
50Pulmonary infiltrates (HP:0002113)2.40818046
51Recurrent bronchitis (HP:0002837)2.36375327
52Combined immunodeficiency (HP:0005387)2.35031621
53Abnormality of eosinophils (HP:0001879)2.34522819
54Bony spicule pigmentary retinopathy (HP:0007737)2.33768651
55Autoimmune hemolytic anemia (HP:0001890)2.33388009
56Panhypogammaglobulinemia (HP:0003139)2.32577675
57Gastrointestinal inflammation (HP:0004386)2.31877467
58IgM deficiency (HP:0002850)2.31590295
59Hypoproteinemia (HP:0003075)2.29616202
60Joint swelling (HP:0001386)2.29131725
61Gingivitis (HP:0000230)2.28510180
62Vasculitis (HP:0002633)2.28401449
63Recurrent cutaneous fungal infections (HP:0011370)2.24559678
64Chronic mucocutaneous candidiasis (HP:0002728)2.24559678
65Lymphopenia (HP:0001888)2.24496987
66Abnormal drinking behavior (HP:0030082)2.24425057
67Polydipsia (HP:0001959)2.24425057
68Thyroiditis (HP:0100646)2.20360085
69Chest pain (HP:0100749)2.18098484
70Bronchiectasis (HP:0002110)2.15591398
71Aplastic anemia (HP:0001915)2.14698700
72Abnormality of T cell physiology (HP:0011840)2.13516514
73Mediastinal lymphadenopathy (HP:0100721)2.12719789
74Abnormality of macular pigmentation (HP:0008002)2.12259909
75Episodic fever (HP:0001954)2.09514337
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08680962
77Microcytic anemia (HP:0001935)2.07655405
78Increased IgE level (HP:0003212)2.07115850
79Chronic diarrhea (HP:0002028)2.06146475
80Keratitis (HP:0000491)2.04375294
81Recurrent gram-negative bacterial infections (HP:0005420)2.02185452
82Prolonged bleeding time (HP:0003010)2.02087606
83Hypoalbuminemia (HP:0003073)2.01782436
84Abnormal albumin level (HP:0012116)2.01782436
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.01559147
86Spontaneous hematomas (HP:0007420)1.98262918
87Abnormality of dental color (HP:0011073)1.97833006
88Facial shape deformation (HP:0011334)1.96782636
89Potter facies (HP:0002009)1.96782636
90Nephronophthisis (HP:0000090)1.95927976
91Petechiae (HP:0000967)1.94758670
92Bronchitis (HP:0012387)1.92974562
93Recurrent pneumonia (HP:0006532)1.92243030
94Hemoptysis (HP:0002105)1.92211334
95Prostate neoplasm (HP:0100787)1.90740885
96Aplasia/Hypoplasia of the earlobes (HP:0009906)1.90698475
97Hyperkalemia (HP:0002153)1.89297064
98Abnormality of the prostate (HP:0008775)1.88906571
99Congenital stationary night blindness (HP:0007642)1.88211599
100Abnormal urine output (HP:0012590)1.85795841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.18670021
2MAP4K13.87004714
3TESK13.26587072
4FES3.05726415
5PLK42.69155228
6TESK22.58853732
7IKBKE2.29445215
8TNK22.23249775
9TLK12.16326886
10CSK2.11018178
11TYK22.10963067
12ZAP702.05215249
13INSRR2.04739065
14GRK61.85202188
15RIPK41.78753626
16BRD41.74199625
17JAK11.71606904
18BTK1.67097954
19SIK31.66585351
20MAP3K111.66279085
21CAMKK21.65535231
22KDR1.59316322
23TYRO31.58188555
24STK381.57139180
25MAP4K21.55776705
26MARK31.52869837
27LCK1.50617447
28GRK71.46845671
29SYK1.45924124
30SIK21.43556723
31IRAK41.41232653
32ADRBK21.40987698
33BLK1.39191504
34PINK11.38633489
35ITK1.37463744
36DDR21.37412260
37ACVR1B1.37015435
38JAK31.25472376
39TAOK31.25190651
40TEC1.24844465
41HCK1.24762908
42PRKCQ1.22452626
43PIK3CG1.15563995
44IKBKB1.13969084
45LYN1.12951874
46MAP3K121.12355840
47STK101.11427493
48PTK2B1.10514410
49PDK11.06762365
50TBK11.02278376
51MAPK150.91510692
52MAP3K40.87587493
53BCKDK0.82694237
54NEK60.78245060
55ZAK0.75947985
56KIT0.75552803
57CAMKK10.75091255
58CDK40.74572931
59MST40.71934298
60CSF1R0.71289254
61FYN0.70676054
62BMPR1B0.70670084
63WNK40.70221765
64DYRK1B0.63189459
65BMX0.60778810
66FGR0.60725199
67HIPK20.58772594
68VRK10.57820001
69CDK30.57316390
70MAPKAPK30.56370049
71PDPK10.54246500
72FRK0.49424111
73JAK20.48918506
74MAP2K20.48073548
75MAP2K60.43755140
76PRKCH0.41027867
77MAP3K10.39172026
78CAMK10.38947533
79STK110.38209739
80RPS6KA60.37539670
81PLK20.36792944
82MAPKAPK20.36499512
83ROCK10.33620297
84RPS6KA20.31131458
85IGF1R0.30820116
86BMPR20.30727602
87PRPF4B0.30310887
88PRKG20.30271362
89WNK10.30022273
90RPS6KA40.29918909
91PASK0.29829356
92LIMK10.29760699
93MAPK130.29669199
94DAPK10.29279803
95TAOK10.28860979
96RPS6KA10.28031448
97PRKG10.27902285
98CDK190.27768581
99PIM10.27206327
100RPS6KC10.27112666

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.55926566
2Primary immunodeficiency_Homo sapiens_hsa053404.47686816
3Antigen processing and presentation_Homo sapiens_hsa046123.75844511
4Allograft rejection_Homo sapiens_hsa053303.64865504
5Autoimmune thyroid disease_Homo sapiens_hsa053203.54914122
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.45818382
7T cell receptor signaling pathway_Homo sapiens_hsa046602.88157588
8Type I diabetes mellitus_Homo sapiens_hsa049402.86235717
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60035763
10Measles_Homo sapiens_hsa051622.16158503
11Viral myocarditis_Homo sapiens_hsa054162.10553753
12Hematopoietic cell lineage_Homo sapiens_hsa046402.09467102
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06411990
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.74684633
15Staphylococcus aureus infection_Homo sapiens_hsa051501.63821631
16Osteoclast differentiation_Homo sapiens_hsa043801.58801937
17Olfactory transduction_Homo sapiens_hsa047401.58037386
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56351282
19Leishmaniasis_Homo sapiens_hsa051401.54763211
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46817560
21Malaria_Homo sapiens_hsa051441.46794438
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41075109
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35015259
24Chemokine signaling pathway_Homo sapiens_hsa040621.33151991
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.32691248
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31374397
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28942374
28Fatty acid biosynthesis_Homo sapiens_hsa000611.26777094
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.23188921
30Herpes simplex infection_Homo sapiens_hsa051681.22757910
31Asthma_Homo sapiens_hsa053101.21977588
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.16229726
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14560461
34Influenza A_Homo sapiens_hsa051641.08028699
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07802015
36B cell receptor signaling pathway_Homo sapiens_hsa046621.07684497
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02196942
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97705981
39Legionellosis_Homo sapiens_hsa051340.96613443
40Endocytosis_Homo sapiens_hsa041440.94460590
41Tuberculosis_Homo sapiens_hsa051520.84917392
42Toxoplasmosis_Homo sapiens_hsa051450.84366376
43Platelet activation_Homo sapiens_hsa046110.79342379
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72511442
45Linoleic acid metabolism_Homo sapiens_hsa005910.69147264
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68164188
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67746580
48Regulation of autophagy_Homo sapiens_hsa041400.67484116
49TNF signaling pathway_Homo sapiens_hsa046680.66780191
50Acute myeloid leukemia_Homo sapiens_hsa052210.65939689
51Morphine addiction_Homo sapiens_hsa050320.64066935
52Taste transduction_Homo sapiens_hsa047420.62712945
53Nitrogen metabolism_Homo sapiens_hsa009100.61815406
54Butanoate metabolism_Homo sapiens_hsa006500.60819035
55Rheumatoid arthritis_Homo sapiens_hsa053230.58778920
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.58746194
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58513233
58Epstein-Barr virus infection_Homo sapiens_hsa051690.58035904
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57327286
60cAMP signaling pathway_Homo sapiens_hsa040240.52456095
61Inositol phosphate metabolism_Homo sapiens_hsa005620.50610853
62Phagosome_Homo sapiens_hsa041450.49093885
63Pertussis_Homo sapiens_hsa051330.48997461
64Viral carcinogenesis_Homo sapiens_hsa052030.48209935
65Glycerolipid metabolism_Homo sapiens_hsa005610.47919934
66ABC transporters_Homo sapiens_hsa020100.47168496
67MAPK signaling pathway_Homo sapiens_hsa040100.47111939
68African trypanosomiasis_Homo sapiens_hsa051430.46752082
69VEGF signaling pathway_Homo sapiens_hsa043700.42784795
70Phototransduction_Homo sapiens_hsa047440.41178225
71Chemical carcinogenesis_Homo sapiens_hsa052040.40845787
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40342447
73Apoptosis_Homo sapiens_hsa042100.37721767
74Dorso-ventral axis formation_Homo sapiens_hsa043200.37714993
75Shigellosis_Homo sapiens_hsa051310.35807177
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.34976553
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34223684
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33956329
79Calcium signaling pathway_Homo sapiens_hsa040200.32136732
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.32053357
81HTLV-I infection_Homo sapiens_hsa051660.30916206
82Oxidative phosphorylation_Homo sapiens_hsa001900.28536416
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28506074
84Selenocompound metabolism_Homo sapiens_hsa004500.28463763
85Type II diabetes mellitus_Homo sapiens_hsa049300.28196589
86Salivary secretion_Homo sapiens_hsa049700.27911571
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26347688
88Peroxisome_Homo sapiens_hsa041460.24592766
89Basal transcription factors_Homo sapiens_hsa030220.22562715
90Cardiac muscle contraction_Homo sapiens_hsa042600.20846865
91Arachidonic acid metabolism_Homo sapiens_hsa005900.19761145
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.19079461
93Parkinsons disease_Homo sapiens_hsa050120.18618927
94Renin secretion_Homo sapiens_hsa049240.17864098
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17520170
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.17275406
97Ether lipid metabolism_Homo sapiens_hsa005650.16409984
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16403221
99Hepatitis B_Homo sapiens_hsa051610.15656292
100Tryptophan metabolism_Homo sapiens_hsa003800.15044308

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