ZNF680

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.43776433
2CENP-A containing nucleosome assembly (GO:0034080)4.04735111
3replication fork processing (GO:0031297)4.03471806
4chromatin remodeling at centromere (GO:0031055)4.03436171
5negative regulation of DNA-dependent DNA replication (GO:2000104)3.81386826
6resolution of meiotic recombination intermediates (GO:0000712)3.66216211
7regulation of DNA endoreduplication (GO:0032875)3.53681269
8histone exchange (GO:0043486)3.53287098
9regulation of centriole replication (GO:0046599)3.46933139
10protein K6-linked ubiquitination (GO:0085020)3.34619924
11regulation of mitotic spindle checkpoint (GO:1903504)3.27866434
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27866434
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27437138
14centriole replication (GO:0007099)3.14292385
15DNA replication-independent nucleosome assembly (GO:0006336)3.13390661
16DNA replication-independent nucleosome organization (GO:0034724)3.13390661
17regulation of spindle organization (GO:0090224)3.12729675
18mitotic sister chromatid cohesion (GO:0007064)3.09486082
19kinetochore organization (GO:0051383)3.06061124
20protein prenylation (GO:0018342)3.05853330
21prenylation (GO:0097354)3.05853330
22negative regulation of DNA recombination (GO:0045910)3.00680591
23synapsis (GO:0007129)3.00554567
24histone H2A acetylation (GO:0043968)2.94355425
25ribosome assembly (GO:0042255)2.93789080
26seminiferous tubule development (GO:0072520)2.92402020
27spindle checkpoint (GO:0031577)2.87456913
28recombinational repair (GO:0000725)2.87003468
29respiratory chain complex IV assembly (GO:0008535)2.86948403
30metaphase plate congression (GO:0051310)2.85901602
31double-strand break repair via homologous recombination (GO:0000724)2.84675423
32negative regulation of sister chromatid segregation (GO:0033046)2.82257359
33negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82257359
34negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82257359
35negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82257359
36negative regulation of mitotic sister chromatid separation (GO:2000816)2.82257359
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78746844
38negative regulation of translation, ncRNA-mediated (GO:0040033)2.78746844
39regulation of translation, ncRNA-mediated (GO:0045974)2.78746844
40mitotic spindle checkpoint (GO:0071174)2.77911459
41double-strand break repair via nonhomologous end joining (GO:0006303)2.77371947
42non-recombinational repair (GO:0000726)2.77371947
43regulation of mitotic spindle organization (GO:0060236)2.75903380
44regulation of nuclear cell cycle DNA replication (GO:0033262)2.75685086
45negative regulation of chromosome segregation (GO:0051985)2.73941823
46intraciliary transport (GO:0042073)2.73341858
47nuclear pore complex assembly (GO:0051292)2.72199052
48mitotic metaphase plate congression (GO:0007080)2.71376141
49regulation of sister chromatid segregation (GO:0033045)2.69689085
50regulation of mitotic sister chromatid separation (GO:0010965)2.69689085
51regulation of mitotic sister chromatid segregation (GO:0033047)2.69689085
52somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69301594
53somatic hypermutation of immunoglobulin genes (GO:0016446)2.69301594
54regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68144193
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68144193
56kinetochore assembly (GO:0051382)2.65991436
57microtubule depolymerization (GO:0007019)2.65615663
58regulation of centrosome duplication (GO:0010824)2.64764158
59nuclear pore organization (GO:0006999)2.64544232
60DNA replication-dependent nucleosome organization (GO:0034723)2.63920416
61DNA replication-dependent nucleosome assembly (GO:0006335)2.63920416
62nonmotile primary cilium assembly (GO:0035058)2.63339329
63presynaptic membrane assembly (GO:0097105)2.63044273
64mitotic spindle assembly checkpoint (GO:0007094)2.62056973
65protein localization to kinetochore (GO:0034501)2.61821174
66spindle assembly checkpoint (GO:0071173)2.61476091
67sister chromatid segregation (GO:0000819)2.60004139
68intra-S DNA damage checkpoint (GO:0031573)2.55093420
69DNA ligation (GO:0006266)2.53107135
70regulation of centrosome cycle (GO:0046605)2.52736619
71postreplication repair (GO:0006301)2.51591219
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51548939
73regulation of meiosis I (GO:0060631)2.51235435
74neural tube formation (GO:0001841)2.50508196
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50120552
76DNA replication checkpoint (GO:0000076)2.50063879
77DNA catabolic process, exonucleolytic (GO:0000738)2.49581593
78proteasome assembly (GO:0043248)2.49126503
79water-soluble vitamin biosynthetic process (GO:0042364)2.46878378
80attachment of spindle microtubules to kinetochore (GO:0008608)2.46285947
81regulation of chromosome segregation (GO:0051983)2.45254736
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44416594
83cytochrome complex assembly (GO:0017004)2.43378645
84microtubule polymerization or depolymerization (GO:0031109)2.43336806
85mitochondrial respiratory chain complex assembly (GO:0033108)2.40914447
86microtubule anchoring (GO:0034453)2.40267871
87centrosome organization (GO:0051297)2.39891525
88protein complex biogenesis (GO:0070271)2.38825698
89microtubule organizing center organization (GO:0031023)2.37915303
90mitotic sister chromatid segregation (GO:0000070)2.37502402
91meiotic chromosome segregation (GO:0045132)2.36703916
92sister chromatid cohesion (GO:0007062)2.36437443
93keratinocyte development (GO:0003334)2.35341769
94transcription from mitochondrial promoter (GO:0006390)2.34568490
95C4-dicarboxylate transport (GO:0015740)2.34414827
96negative regulation of mitosis (GO:0045839)2.33550110
97response to pheromone (GO:0019236)2.33424337
98otic vesicle formation (GO:0030916)2.33395138
99acrosome assembly (GO:0001675)2.31468448
100regulation of helicase activity (GO:0051095)2.30323615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.70728185
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89982777
3ZNF274_21170338_ChIP-Seq_K562_Hela2.79545573
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76577419
5IGF1R_20145208_ChIP-Seq_DFB_Human2.61581210
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56882412
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51653062
8FUS_26573619_Chip-Seq_HEK293_Human2.50491706
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40945035
10E2F7_22180533_ChIP-Seq_HELA_Human2.39207226
11EWS_26573619_Chip-Seq_HEK293_Human2.33904127
12TAF15_26573619_Chip-Seq_HEK293_Human2.31599092
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30761859
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.27752544
15GBX2_23144817_ChIP-Seq_PC3_Human2.25889253
16ELK1_19687146_ChIP-ChIP_HELA_Human2.24849732
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23768808
18VDR_22108803_ChIP-Seq_LS180_Human2.14406717
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.13503171
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00966846
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99679380
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.97001518
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88807404
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87293257
25P300_19829295_ChIP-Seq_ESCs_Human1.87202563
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82064124
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.76429726
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75591852
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71632597
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68977912
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65160567
32ER_23166858_ChIP-Seq_MCF-7_Human1.61154497
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56780199
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56626358
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55604831
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54902470
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54298252
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52299641
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47687823
40SMAD4_21799915_ChIP-Seq_A2780_Human1.47408514
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.44522894
42VDR_23849224_ChIP-Seq_CD4+_Human1.44368976
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43971658
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43819001
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40119769
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38677237
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.34196250
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32948267
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32382323
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32213911
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30540445
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29040076
53CBP_20019798_ChIP-Seq_JUKART_Human1.29040076
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28722430
55STAT3_23295773_ChIP-Seq_U87_Human1.27676335
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26747596
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.26731643
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24405206
59* MYC_18940864_ChIP-ChIP_HL60_Human1.23842179
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23625600
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.22708913
62BCAT_22108803_ChIP-Seq_LS180_Human1.22653677
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21867213
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21632187
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21575266
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19702253
67AR_25329375_ChIP-Seq_VCAP_Human1.18237355
68TCF4_23295773_ChIP-Seq_U87_Human1.15191135
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15097272
70TCF4_22108803_ChIP-Seq_LS180_Human1.14700922
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13072131
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.11461432
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.10623723
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10120651
75HTT_18923047_ChIP-ChIP_STHdh_Human1.09946421
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09759345
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09245244
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.08923750
79P53_22387025_ChIP-Seq_ESCs_Mouse1.06901898
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.06266558
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05813408
82FOXP3_21729870_ChIP-Seq_TREG_Human1.05443070
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.05111944
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04977205
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.04688471
86AR_21909140_ChIP-Seq_LNCAP_Human1.04661289
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04485414
88SOX2_19829295_ChIP-Seq_ESCs_Human1.03787640
89NANOG_19829295_ChIP-Seq_ESCs_Human1.03787640
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.02513570
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.02293050
92IRF1_19129219_ChIP-ChIP_H3396_Human1.01343578
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00895139
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00225669
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99420100
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.99288404
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.99020488
98TP53_22573176_ChIP-Seq_HFKS_Human0.98140249
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.97940519
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94629588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.68068966
2MP0008057_abnormal_DNA_replication3.59731627
3MP0008877_abnormal_DNA_methylation3.34806147
4MP0010094_abnormal_chromosome_stability2.72798238
5MP0003195_calcinosis2.25633900
6MP0008058_abnormal_DNA_repair2.20138924
7MP0003890_abnormal_embryonic-extraembry2.19358514
8MP0002837_dystrophic_cardiac_calcinosis2.10016886
9MP0009697_abnormal_copulation1.99054065
10MP0000372_irregular_coat_pigmentation1.95978928
11MP0003693_abnormal_embryo_hatching1.91585460
12MP0003880_abnormal_central_pattern1.87163103
13MP0002938_white_spotting1.86067584
14MP0003787_abnormal_imprinting1.84368160
15MP0006072_abnormal_retinal_apoptosis1.76730110
16MP0008995_early_reproductive_senescence1.74896554
17MP0003718_maternal_effect1.71301171
18MP0001984_abnormal_olfaction1.66218306
19MP0005551_abnormal_eye_electrophysiolog1.60252646
20MP0006292_abnormal_olfactory_placode1.54423295
21MP0002102_abnormal_ear_morphology1.51944043
22MP0003121_genomic_imprinting1.47362107
23MP0001293_anophthalmia1.46829195
24MP0004957_abnormal_blastocyst_morpholog1.45994083
25MP0000427_abnormal_hair_cycle1.45391575
26MP0003136_yellow_coat_color1.45168806
27MP0005253_abnormal_eye_physiology1.44220822
28MP0003567_abnormal_fetal_cardiomyocyte1.42295397
29MP0004215_abnormal_myocardial_fiber1.42087602
30MP0002090_abnormal_vision1.39560218
31MP0009046_muscle_twitch1.37084291
32MP0005174_abnormal_tail_pigmentation1.35019555
33MP0003077_abnormal_cell_cycle1.32852214
34MP0003011_delayed_dark_adaptation1.31779256
35MP0000631_abnormal_neuroendocrine_gland1.29038982
36MP0006054_spinal_hemorrhage1.27557745
37MP0003111_abnormal_nucleus_morphology1.27474304
38MP0005075_abnormal_melanosome_morpholog1.25737791
39MP0003786_premature_aging1.25048776
40MP0000383_abnormal_hair_follicle1.24306746
41MP0006035_abnormal_mitochondrial_morpho1.22941725
42MP0001324_abnormal_eye_pigmentation1.19407734
43MP0005645_abnormal_hypothalamus_physiol1.18289761
44MP0003937_abnormal_limbs/digits/tail_de1.17131647
45MP0008007_abnormal_cellular_replicative1.15319225
46MP0002009_preneoplasia1.14719805
47MP0001486_abnormal_startle_reflex1.14473996
48MP0008789_abnormal_olfactory_epithelium1.13919323
49MP0001929_abnormal_gametogenesis1.13845544
50MP0002638_abnormal_pupillary_reflex1.11333797
51MP0003943_abnormal_hepatobiliary_system1.11225638
52MP0004133_heterotaxia1.09858673
53MP0000647_abnormal_sebaceous_gland1.09751855
54MP0002233_abnormal_nose_morphology1.08457147
55MP0001485_abnormal_pinna_reflex1.08185170
56MP0005646_abnormal_pituitary_gland1.06915414
57MP0006276_abnormal_autonomic_nervous1.05026620
58MP0000778_abnormal_nervous_system1.03305221
59MP0008932_abnormal_embryonic_tissue1.02654357
60MP0002095_abnormal_skin_pigmentation1.02297315
61MP0002210_abnormal_sex_determination1.00611177
62MP0002234_abnormal_pharynx_morphology0.98792040
63MP0000015_abnormal_ear_pigmentation0.97637150
64MP0002751_abnormal_autonomic_nervous0.97168403
65MP0004084_abnormal_cardiac_muscle0.97040297
66MP0001529_abnormal_vocalization0.96066476
67MP0003941_abnormal_skin_development0.94609757
68MP0002736_abnormal_nociception_after0.93654481
69MP0000653_abnormal_sex_gland0.92224380
70MP0001145_abnormal_male_reproductive0.92146760
71MP0002160_abnormal_reproductive_system0.91952754
72MP0004885_abnormal_endolymph0.91739423
73MP0003698_abnormal_male_reproductive0.91262851
74MP0004270_analgesia0.90945113
75MP0003122_maternal_imprinting0.90338565
76MP0004147_increased_porphyrin_level0.90119820
77MP0001286_abnormal_eye_development0.90078928
78MP0003646_muscle_fatigue0.89906024
79MP0010678_abnormal_skin_adnexa0.88622011
80MP0005394_taste/olfaction_phenotype0.85846274
81MP0005499_abnormal_olfactory_system0.85846274
82MP0006036_abnormal_mitochondrial_physio0.85271704
83MP0002084_abnormal_developmental_patter0.84605161
84MP0009703_decreased_birth_body0.82512719
85MP0005248_abnormal_Harderian_gland0.82504343
86MP0002272_abnormal_nervous_system0.79517794
87MP0005391_vision/eye_phenotype0.79310734
88MP0000358_abnormal_cell_content/0.78759489
89MP0002653_abnormal_ependyma_morphology0.78535061
90MP0005187_abnormal_penis_morphology0.78269699
91MP0009745_abnormal_behavioral_response0.78253913
92MP0001188_hyperpigmentation0.78035447
93MP0005395_other_phenotype0.78027104
94MP0001697_abnormal_embryo_size0.77063461
95MP0004085_abnormal_heartbeat0.76265111
96MP0002697_abnormal_eye_size0.75870979
97MP0001968_abnormal_touch/_nociception0.75574471
98MP0000371_diluted_coat_color0.74220499
99MP0004043_abnormal_pH_regulation0.71984796
100MP0002735_abnormal_chemical_nociception0.71381327

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.58289077
2True hermaphroditism (HP:0010459)3.39667445
3Abnormality of chromosome stability (HP:0003220)3.18732972
4Aplasia/Hypoplasia of the uvula (HP:0010293)2.91041114
5Pancreatic cysts (HP:0001737)2.90570740
6Pancreatic fibrosis (HP:0100732)2.87936655
7Colon cancer (HP:0003003)2.85004812
8Abnormality of midbrain morphology (HP:0002418)2.84428659
9Molar tooth sign on MRI (HP:0002419)2.84428659
10Degeneration of the lateral corticospinal tracts (HP:0002314)2.80922408
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80922408
12Intestinal atresia (HP:0011100)2.73701605
13Nephronophthisis (HP:0000090)2.72078420
14Meckel diverticulum (HP:0002245)2.71670905
15Abnormality of the labia minora (HP:0012880)2.69979434
16Medial flaring of the eyebrow (HP:0010747)2.64595844
17Abnormality of the ileum (HP:0001549)2.62155318
18Methylmalonic acidemia (HP:0002912)2.58004333
19Chromsome breakage (HP:0040012)2.51483827
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50299352
21Abnormal lung lobation (HP:0002101)2.43046039
22Chronic hepatic failure (HP:0100626)2.36189104
23Congenital primary aphakia (HP:0007707)2.32564235
24Abnormality of methionine metabolism (HP:0010901)2.32258293
25Abnormality of the preputium (HP:0100587)2.30520227
26Gait imbalance (HP:0002141)2.26203836
27Hyperinsulinemic hypoglycemia (HP:0000825)2.21566812
28Abnormality of the renal medulla (HP:0100957)2.20561245
29Sloping forehead (HP:0000340)2.20242142
30Gonadotropin excess (HP:0000837)2.18711183
31Genital tract atresia (HP:0001827)2.16158100
32Nephrogenic diabetes insipidus (HP:0009806)2.15760062
33Abnormality of the duodenum (HP:0002246)2.15137286
34Abnormality of the corticospinal tract (HP:0002492)2.15030298
35Vaginal atresia (HP:0000148)2.12013242
36Male pseudohermaphroditism (HP:0000037)2.10350267
37Glioma (HP:0009733)2.07299488
38Small intestinal stenosis (HP:0012848)2.06973822
39Duodenal stenosis (HP:0100867)2.06973822
40Abnormality of the renal cortex (HP:0011035)2.06543169
41Renal cortical cysts (HP:0000803)2.02552191
42Poor coordination (HP:0002370)2.02179296
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.01749394
44Abnormality of vitamin B metabolism (HP:0004340)1.98516209
45Tubulointerstitial nephritis (HP:0001970)1.98493122
46Hyperglycinemia (HP:0002154)1.98491388
47Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97395049
48Hypoglycemic coma (HP:0001325)1.97170472
49Progressive macrocephaly (HP:0004481)1.94225680
50Acute necrotizing encephalopathy (HP:0006965)1.93550132
51Acute encephalopathy (HP:0006846)1.92936493
52Rhabdomyosarcoma (HP:0002859)1.90885985
53Congenital malformation of the right heart (HP:0011723)1.88204921
54Double outlet right ventricle (HP:0001719)1.88204921
55Myelodysplasia (HP:0002863)1.87499390
56Astigmatism (HP:0000483)1.86405531
57Clubbing of toes (HP:0100760)1.85183466
58Abnormality of the vitamin B12 metabolism (HP:0004341)1.84238379
59Gaze-evoked nystagmus (HP:0000640)1.83883711
60Hyperventilation (HP:0002883)1.83364579
61Gastrointestinal atresia (HP:0002589)1.82203279
62Progressive inability to walk (HP:0002505)1.81760925
63Aplasia/Hypoplasia of the tibia (HP:0005772)1.80842882
64Bifid tongue (HP:0010297)1.79769186
65Medulloblastoma (HP:0002885)1.79712314
66Abnormality of homocysteine metabolism (HP:0010919)1.79673620
67Homocystinuria (HP:0002156)1.79673620
68Increased CSF lactate (HP:0002490)1.78445521
69Postaxial hand polydactyly (HP:0001162)1.78388724
70Triphalangeal thumb (HP:0001199)1.76961952
71Nephroblastoma (Wilms tumor) (HP:0002667)1.76631613
72Clitoromegaly (HP:0000057)1.75628019
73Impaired vibration sensation in the lower limbs (HP:0002166)1.75003767
74Sclerocornea (HP:0000647)1.74646862
75Papillary thyroid carcinoma (HP:0002895)1.74407430
76Abnormality of the astrocytes (HP:0100707)1.74405355
77Astrocytoma (HP:0009592)1.74405355
78Abnormality of the carotid arteries (HP:0005344)1.74172109
79Gonadal dysgenesis (HP:0000133)1.74005513
80Postaxial foot polydactyly (HP:0001830)1.73299422
81Pancreatic islet-cell hyperplasia (HP:0004510)1.71254657
82Embryonal renal neoplasm (HP:0011794)1.70894943
83Hypoglycemic seizures (HP:0002173)1.70309376
84Congenital hepatic fibrosis (HP:0002612)1.69690405
85Increased hepatocellular lipid droplets (HP:0006565)1.69083592
86Bile duct proliferation (HP:0001408)1.68938534
87Abnormal biliary tract physiology (HP:0012439)1.68938534
88Ovarian neoplasm (HP:0100615)1.68774138
89Agnosia (HP:0010524)1.68263145
90Lipid accumulation in hepatocytes (HP:0006561)1.68257059
91Median cleft lip (HP:0000161)1.66519090
92Ependymoma (HP:0002888)1.65774130
93Hyperglycinuria (HP:0003108)1.65685525
94Narrow forehead (HP:0000341)1.64483596
95Specific learning disability (HP:0001328)1.63795372
96Abnormality of macular pigmentation (HP:0008002)1.62629449
97Absent eyebrow (HP:0002223)1.62128330
98Oculomotor apraxia (HP:0000657)1.61265625
99Supernumerary spleens (HP:0009799)1.61234148
100Preaxial hand polydactyly (HP:0001177)1.60495080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.39201188
2MKNK22.54134039
3WNK32.44925156
4BRSK22.32113089
5PLK42.31039663
6BUB12.29982379
7PBK2.22918270
8ZAK2.22582744
9EIF2AK32.19757898
10BMPR1B2.18177470
11TTK1.99199883
12MST41.96794159
13TRIM281.93987527
14WEE11.92253115
15MKNK11.87789010
16PLK31.87328271
17NEK11.85561303
18MAP4K21.84033029
19TNIK1.82358014
20EIF2AK11.76221831
21TSSK61.68468877
22INSRR1.67415776
23ACVR1B1.63136348
24MAPK131.60155622
25MAP3K41.59070702
26CDC71.58494942
27CASK1.57992207
28NUAK11.53920959
29SRPK11.49584916
30PINK11.49137898
31PNCK1.44312519
32STK391.37756015
33VRK11.34486285
34ERBB31.32380132
35OBSCN1.31932462
36AKT31.23944343
37OXSR11.21812964
38BCR1.21505581
39CCNB11.18287705
40PLK11.16261906
41EPHA41.15376815
42STK38L1.13856906
43FGFR21.07855401
44PLK21.06578871
45CSNK1G11.05233767
46STK161.02157222
47VRK20.99499590
48NTRK30.98803817
49CSNK1G20.96716667
50STK30.96006310
51BRD40.95654237
52PAK30.94774112
53TAF10.91779353
54CDK30.88754648
55ATR0.87653740
56NLK0.86623770
57MAP2K70.85859525
58CSNK1G30.81996094
59GRK10.81886741
60ATM0.79065276
61FER0.71905912
62CDK190.69461507
63LATS10.66234590
64EIF2AK20.65133904
65PRKCE0.64649084
66AURKB0.63338834
67CHEK20.63258710
68CSNK1A1L0.60711684
69MINK10.58628627
70PHKG20.57940378
71PHKG10.57940378
72TGFBR10.57179913
73DYRK20.55416591
74YES10.55128065
75BRSK10.53484345
76CHEK10.52989551
77PRKCG0.52977765
78EPHA30.52114249
79MAP3K120.50786456
80PASK0.48982242
81PKN10.48884112
82STK40.48232909
83NEK60.46761560
84MUSK0.45816942
85FGFR10.45438639
86CSNK1E0.43701350
87RPS6KA40.43653169
88PRKDC0.43543414
89DYRK30.43196558
90CDK10.42102583
91MARK10.41603737
92NTRK20.40280371
93CSNK1D0.37528633
94NEK20.36926476
95CAMK2A0.35102915
96PDK20.34770617
97PRKACB0.34341942
98CSNK1A10.33871421
99RPS6KB10.33601629
100SGK20.33314654

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.93144901
2Propanoate metabolism_Homo sapiens_hsa006402.82814302
3Non-homologous end-joining_Homo sapiens_hsa034502.75043167
4Homologous recombination_Homo sapiens_hsa034402.66944146
5Mismatch repair_Homo sapiens_hsa034302.65229509
6Protein export_Homo sapiens_hsa030602.51656037
7Basal transcription factors_Homo sapiens_hsa030222.30328496
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11293599
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03892657
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03458831
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83525825
12Butanoate metabolism_Homo sapiens_hsa006501.79590600
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78979466
14Proteasome_Homo sapiens_hsa030501.78197802
15Selenocompound metabolism_Homo sapiens_hsa004501.75060306
16RNA degradation_Homo sapiens_hsa030181.74792158
17Nucleotide excision repair_Homo sapiens_hsa034201.73850093
18RNA transport_Homo sapiens_hsa030131.73635547
19RNA polymerase_Homo sapiens_hsa030201.70740759
20DNA replication_Homo sapiens_hsa030301.69611609
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66138525
22Oxidative phosphorylation_Homo sapiens_hsa001901.65381797
23Fatty acid elongation_Homo sapiens_hsa000621.59905776
24One carbon pool by folate_Homo sapiens_hsa006701.56922708
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.48413688
26Cell cycle_Homo sapiens_hsa041101.45762387
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.41817169
28Parkinsons disease_Homo sapiens_hsa050121.35480639
29Circadian rhythm_Homo sapiens_hsa047101.30910570
30Oocyte meiosis_Homo sapiens_hsa041141.26854115
31Spliceosome_Homo sapiens_hsa030401.24882570
32Pyruvate metabolism_Homo sapiens_hsa006201.21341744
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21086891
34Steroid biosynthesis_Homo sapiens_hsa001001.20594501
35beta-Alanine metabolism_Homo sapiens_hsa004101.19619351
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16014593
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.14025658
38Huntingtons disease_Homo sapiens_hsa050161.13868277
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08903266
40Peroxisome_Homo sapiens_hsa041461.08397669
41Regulation of autophagy_Homo sapiens_hsa041401.07213834
42Fatty acid metabolism_Homo sapiens_hsa012121.07125671
43Base excision repair_Homo sapiens_hsa034101.03553746
44Purine metabolism_Homo sapiens_hsa002301.02760941
45Vitamin B6 metabolism_Homo sapiens_hsa007501.02166852
46Phototransduction_Homo sapiens_hsa047440.98562069
47Lysine degradation_Homo sapiens_hsa003100.96743710
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96609185
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96405185
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96204339
51mRNA surveillance pathway_Homo sapiens_hsa030150.95751775
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95343247
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94282740
54Caffeine metabolism_Homo sapiens_hsa002320.92843791
55Fatty acid degradation_Homo sapiens_hsa000710.92166557
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88386188
57Nicotine addiction_Homo sapiens_hsa050330.88005620
58Folate biosynthesis_Homo sapiens_hsa007900.87040288
59Tryptophan metabolism_Homo sapiens_hsa003800.86841859
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84333290
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83099480
62Alzheimers disease_Homo sapiens_hsa050100.82378107
63Retinol metabolism_Homo sapiens_hsa008300.81247574
64Insulin secretion_Homo sapiens_hsa049110.81049150
65Pyrimidine metabolism_Homo sapiens_hsa002400.80264630
66Taste transduction_Homo sapiens_hsa047420.78311982
67Chemical carcinogenesis_Homo sapiens_hsa052040.76720165
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.70201749
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67513323
70Cardiac muscle contraction_Homo sapiens_hsa042600.65695362
71Metabolic pathways_Homo sapiens_hsa011000.63944481
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62959056
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62423588
74Glutathione metabolism_Homo sapiens_hsa004800.61045207
75p53 signaling pathway_Homo sapiens_hsa041150.59364367
76Nitrogen metabolism_Homo sapiens_hsa009100.59196320
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57992907
78TGF-beta signaling pathway_Homo sapiens_hsa043500.55254435
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51747179
80Olfactory transduction_Homo sapiens_hsa047400.50946540
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49452549
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48305814
83Alcoholism_Homo sapiens_hsa050340.47973131
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46276223
85Collecting duct acid secretion_Homo sapiens_hsa049660.46159513
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45285440
87Glutamatergic synapse_Homo sapiens_hsa047240.39673468
88ABC transporters_Homo sapiens_hsa020100.37808180
89Ether lipid metabolism_Homo sapiens_hsa005650.37502125
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36771796
91GABAergic synapse_Homo sapiens_hsa047270.36482757
92Hippo signaling pathway_Homo sapiens_hsa043900.35740262
93Circadian entrainment_Homo sapiens_hsa047130.35705856
94Linoleic acid metabolism_Homo sapiens_hsa005910.34648084
95Hedgehog signaling pathway_Homo sapiens_hsa043400.33670803
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33570315
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33198008
98Carbon metabolism_Homo sapiens_hsa012000.32876626
99Arginine and proline metabolism_Homo sapiens_hsa003300.31830160
100Ribosome_Homo sapiens_hsa030100.31243856

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