ZNF679

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)7.23936362
2meiosis I (GO:0007127)6.20277957
3multicellular organism reproduction (GO:0032504)4.65305138
4male meiosis (GO:0007140)4.28530780
5regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.23072562
6regulation of acrosome reaction (GO:0060046)4.17959030
7histone H3-K9 demethylation (GO:0033169)4.12527249
8mitotic metaphase plate congression (GO:0007080)4.06382678
9negative regulation of retinoic acid receptor signaling pathway (GO:0048387)36.4479760
10regulation of retinoic acid receptor signaling pathway (GO:0048385)30.5416953
11regulation of DNA methylation (GO:0044030)3.99149333
12positive regulation of protein homooligomerization (GO:0032464)3.75108106
13transcription from mitochondrial promoter (GO:0006390)3.68027597
14chromosome condensation (GO:0030261)3.67488050
15rRNA modification (GO:0000154)3.65890612
16binding of sperm to zona pellucida (GO:0007339)3.45664339
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40446229
18mitotic chromosome condensation (GO:0007076)3.39500622
19positive regulation of uterine smooth muscle contraction (GO:0070474)3.38761270
20reproduction (GO:0000003)3.37438513
21regulation of exit from mitosis (GO:0007096)3.26493835
22chaperone-mediated protein transport (GO:0072321)3.26448973
23meiotic nuclear division (GO:0007126)3.25451511
24DNA packaging (GO:0006323)3.24244015
25rRNA methylation (GO:0031167)3.17318069
26metaphase plate congression (GO:0051310)3.16472336
27ribosome assembly (GO:0042255)3.08506510
28acrosome reaction (GO:0007340)3.08301888
29spermatid nucleus differentiation (GO:0007289)3.07045463
30regulation of histone H3-K9 methylation (GO:0051570)3.07022850
31regulation of female receptivity (GO:0045924)3.05219459
32oocyte development (GO:0048599)3.03881632
33meiotic cell cycle (GO:0051321)3.03857386
34regulation of female gonad development (GO:2000194)2.98068580
35meiotic cell cycle process (GO:1903046)2.97606688
36sperm-egg recognition (GO:0035036)2.96134602
37piRNA metabolic process (GO:0034587)2.95603133
38autophagic vacuole assembly (GO:0000045)2.95333625
39aggressive behavior (GO:0002118)2.93852590
40N-terminal protein amino acid acetylation (GO:0006474)2.85433674
41ventricular cardiac muscle cell development (GO:0055015)2.84311049
42regulation of spindle organization (GO:0090224)2.82367336
43maturation of SSU-rRNA (GO:0030490)2.79850111
44attachment of spindle microtubules to kinetochore (GO:0008608)2.79582306
45histone exchange (GO:0043486)2.73494908
46CENP-A containing nucleosome assembly (GO:0034080)2.72756999
47protein localization to chromosome, centromeric region (GO:0071459)2.72380099
48fusion of sperm to egg plasma membrane (GO:0007342)2.71540994
49polyamine biosynthetic process (GO:0006596)2.68906704
50drinking behavior (GO:0042756)2.68339715
51hyperosmotic salinity response (GO:0042538)2.66823507
52protein K6-linked ubiquitination (GO:0085020)2.66726560
53single fertilization (GO:0007338)2.65713604
54retinal cone cell development (GO:0046549)2.65650513
55snRNA transcription (GO:0009301)2.65018232
56single strand break repair (GO:0000012)2.62044868
57female mating behavior (GO:0060180)2.60827824
58regulation of cytokine production involved in inflammatory response (GO:1900015)2.60277830
59microtubule polymerization or depolymerization (GO:0031109)2.59432768
60positive regulation of catecholamine secretion (GO:0033605)2.59204784
61regulation of mitotic spindle organization (GO:0060236)2.58472393
62regulation of uterine smooth muscle contraction (GO:0070472)2.55657667
63positive regulation of histone H3-K4 methylation (GO:0051571)2.53889691
64kinetochore assembly (GO:0051382)2.53784553
65positive regulation of gastrulation (GO:2000543)2.52936457
66sleep (GO:0030431)2.50669243
67regulation of G0 to G1 transition (GO:0070316)2.48129269
68primitive streak formation (GO:0090009)2.46773618
69chromatin remodeling at centromere (GO:0031055)2.46392632
70negative regulation of reproductive process (GO:2000242)2.45969484
71positive regulation of prostaglandin secretion (GO:0032308)2.45512149
72regulation of penile erection (GO:0060405)2.44857973
73histone mRNA metabolic process (GO:0008334)2.44407450
74gamete generation (GO:0007276)2.42375201
75regulation of helicase activity (GO:0051095)2.41130030
76regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.41005556
77termination of RNA polymerase III transcription (GO:0006386)2.40608913
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.40608913
79DNA replication checkpoint (GO:0000076)2.38254957
80synaptonemal complex organization (GO:0070193)2.38051995
81microtubule depolymerization (GO:0007019)2.37235494
82cell-cell recognition (GO:0009988)2.37177497
83response to acidic pH (GO:0010447)2.35497907
84spermatogenesis (GO:0007283)2.35227982
85male gamete generation (GO:0048232)2.34450281
86negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.30575186
87spermatid development (GO:0007286)2.30402303
88telomere maintenance via telomere lengthening (GO:0010833)2.28925642
89positive regulation of meiotic cell cycle (GO:0051446)2.28720728
90oocyte maturation (GO:0001556)2.28056050
91positive regulation of chromosome segregation (GO:0051984)2.27863921
92DNA methylation involved in gamete generation (GO:0043046)2.27660754
93fertilization (GO:0009566)2.27337984
94positive regulation of digestive system process (GO:0060456)2.26827741
95regulation of cell cycle G2/M phase transition (GO:1902749)2.24320186
96cellular response to pH (GO:0071467)2.24269268
97establishment of chromosome localization (GO:0051303)2.24208597
98centriole replication (GO:0007099)2.23331344
99regulation of meiosis I (GO:0060631)2.22254944
100nuclear pore complex assembly (GO:0051292)2.20765253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95956966
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.90995957
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.81470838
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.74679578
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.17300176
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.17300176
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.17300176
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.91366359
9NOTCH1_21737748_ChIP-Seq_TLL_Human3.83607013
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.56378501
11E2F7_22180533_ChIP-Seq_HELA_Human3.56235207
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.32445631
13TP63_19390658_ChIP-ChIP_HaCaT_Human3.16504003
14ZNF274_21170338_ChIP-Seq_K562_Hela3.00600205
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91745805
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80906249
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59258346
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49101147
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.45028655
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31656737
21ETV1_20927104_ChIP-Seq_GIST48_Human2.27536492
22RBPJ_21746931_ChIP-Seq_IB4_Human2.18924357
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13707793
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.11157467
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07827645
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.07483751
27TBL1_22424771_ChIP-Seq_293T_Human1.95494282
28NFYB_21822215_ChIP-Seq_K562_Human1.91022692
29PHF8_20622853_ChIP-Seq_HELA_Human1.88772375
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82791915
31MYC_18940864_ChIP-ChIP_HL60_Human1.80461370
32AR_21909140_ChIP-Seq_LNCAP_Human1.75651447
33GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.67813129
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.67286917
35GATA6_21074721_ChIP-Seq_CACO-2_Human1.64791594
36HNFA_21074721_ChIP-Seq_CACO-2_Human1.57605664
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53673755
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51497949
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41499639
40TTF2_22483619_ChIP-Seq_HELA_Human1.40885810
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38880483
42VDR_23849224_ChIP-Seq_CD4+_Human1.35636793
43NFYA_21822215_ChIP-Seq_K562_Human1.31244083
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.30644925
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.26974952
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26616058
47NANOG_20526341_ChIP-Seq_ESCs_Human1.24218663
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21446544
49PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20402796
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19774925
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17073996
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.14113824
53RAC3_21632823_ChIP-Seq_H3396_Human1.13972564
54KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12115778
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11973046
56ELK1_19687146_ChIP-ChIP_HELA_Human1.09967771
57LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06040641
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04831772
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04508572
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03065687
61FOXP3_21729870_ChIP-Seq_TREG_Human1.02076393
62TP53_22573176_ChIP-Seq_HFKS_Human1.01593576
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00431048
64NCOR_22424771_ChIP-Seq_293T_Human0.99807964
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99773906
66AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99338834
67* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98647808
68VDR_22108803_ChIP-Seq_LS180_Human0.98086993
69NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97249837
70RNF2_27304074_Chip-Seq_NSC_Mouse0.96676540
71MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95836866
72TAF15_26573619_Chip-Seq_HEK293_Human0.95397582
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95050077
74XRN2_22483619_ChIP-Seq_HELA_Human0.93970506
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92813724
76GABP_19822575_ChIP-Seq_HepG2_Human0.91998116
77CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89041572
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88554577
79ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85590410
80STAT1_20625510_ChIP-Seq_HELA_Human0.84080895
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82574154
82HOXB7_26014856_ChIP-Seq_BT474_Human0.81600938
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81534365
84IRF1_19129219_ChIP-ChIP_H3396_Human0.81165768
85CTCF_20526341_ChIP-Seq_ESCs_Human0.80485043
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80091750
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79906190
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79795780
89KDM5A_27292631_Chip-Seq_BREAST_Human0.79391905
90MYC_19829295_ChIP-Seq_ESCs_Human0.78227261
91IGF1R_20145208_ChIP-Seq_DFB_Human0.76225204
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75116531
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74435201
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72113524
95GATA3_26560356_Chip-Seq_TH1_Human0.71071893
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.69991962
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69991962
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.69677129
99STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.69520655
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.68813056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.00458627
2MP0005423_abnormal_somatic_nervous5.07856719
3MP0001986_abnormal_taste_sensitivity4.97655627
4MP0003718_maternal_effect4.42220005
5MP0005410_abnormal_fertilization3.72356109
6MP0009379_abnormal_foot_pigmentation3.47662575
7MP0003693_abnormal_embryo_hatching3.05450453
8MP0005394_taste/olfaction_phenotype2.92296404
9MP0005499_abnormal_olfactory_system2.92296404
10MP0003136_yellow_coat_color2.76727114
11MP0001929_abnormal_gametogenesis2.63853154
12MP0002127_abnormal_cardiovascular_syste2.40989088
13MP0008877_abnormal_DNA_methylation2.39580495
14MP0010307_abnormal_tumor_latency2.39352619
15MP0004957_abnormal_blastocyst_morpholog2.30630470
16MP0010030_abnormal_orbit_morphology2.30623898
17MP0002160_abnormal_reproductive_system2.25369165
18MP0003077_abnormal_cell_cycle2.18015689
19MP0002210_abnormal_sex_determination2.15324062
20MP0008789_abnormal_olfactory_epithelium2.15316058
21MP0010094_abnormal_chromosome_stability2.12148588
22MP0008058_abnormal_DNA_repair2.11659067
23MP0003111_abnormal_nucleus_morphology2.06851533
24MP0000372_irregular_coat_pigmentation1.96730413
25MP0002277_abnormal_respiratory_mucosa1.92624488
26MP0008057_abnormal_DNA_replication1.92209018
27MP0003698_abnormal_male_reproductive1.92117730
28MP0002161_abnormal_fertility/fecundity1.62090224
29MP0002234_abnormal_pharynx_morphology1.61307257
30MP0005395_other_phenotype1.56554823
31MP0000653_abnormal_sex_gland1.49863348
32MP0003646_muscle_fatigue1.48062037
33MP0001293_anophthalmia1.47230482
34MP0005389_reproductive_system_phenotype1.45807178
35MP0003890_abnormal_embryonic-extraembry1.40730285
36MP0003699_abnormal_female_reproductive1.39440669
37MP0001145_abnormal_male_reproductive1.36952564
38MP0000049_abnormal_middle_ear1.31009507
39MP0003121_genomic_imprinting1.30244778
40MP0006276_abnormal_autonomic_nervous1.27410757
41MP0002138_abnormal_hepatobiliary_system1.27191307
42MP0001881_abnormal_mammary_gland1.23197167
43MP0009333_abnormal_splenocyte_physiolog1.22432903
44MP0001672_abnormal_embryogenesis/_devel1.16030361
45MP0005380_embryogenesis_phenotype1.16030361
46MP0005647_abnormal_sex_gland1.11535154
47MP0008932_abnormal_embryonic_tissue1.11342432
48MP0008995_early_reproductive_senescence1.03421088
49MP0009840_abnormal_foam_cell1.01989474
50MP0001730_embryonic_growth_arrest1.01906190
51MP0008260_abnormal_autophagy1.01765605
52MP0003879_abnormal_hair_cell0.99581230
53MP0003119_abnormal_digestive_system0.97798370
54MP0003938_abnormal_ear_development0.95806052
55MP0005646_abnormal_pituitary_gland0.95211426
56MP0000678_abnormal_parathyroid_gland0.91944064
57MP0001502_abnormal_circadian_rhythm0.88101393
58MP0002751_abnormal_autonomic_nervous0.87858397
59MP0002233_abnormal_nose_morphology0.87610035
60MP0001666_abnormal_nutrient_absorption0.87017467
61MP0000350_abnormal_cell_proliferation0.86964811
62MP0003984_embryonic_growth_retardation0.86119812
63MP0001119_abnormal_female_reproductive0.85209033
64MP0002254_reproductive_system_inflammat0.82890613
65MP0002088_abnormal_embryonic_growth/wei0.81767877
66MP0003936_abnormal_reproductive_system0.80591860
67MP0005551_abnormal_eye_electrophysiolog0.79412584
68MP0003950_abnormal_plasma_membrane0.78647569
69MP0006036_abnormal_mitochondrial_physio0.78305826
70MP0001286_abnormal_eye_development0.76635780
71MP0001697_abnormal_embryo_size0.75429435
72MP0010368_abnormal_lymphatic_system0.74094349
73MP0002102_abnormal_ear_morphology0.72773068
74MP0000762_abnormal_tongue_morphology0.70008029
75MP0000631_abnormal_neuroendocrine_gland0.69552046
76MP0002085_abnormal_embryonic_tissue0.68798927
77MP0003755_abnormal_palate_morphology0.68278597
78MP0004215_abnormal_myocardial_fiber0.67729903
79MP0005360_urolithiasis0.67675647
80MP0002084_abnormal_developmental_patter0.65968901
81MP0001968_abnormal_touch/_nociception0.65651516
82MP0000428_abnormal_craniofacial_morphol0.64842398
83MP0002163_abnormal_gland_morphology0.64278812
84MP0004381_abnormal_hair_follicle0.63130625
85MP0005379_endocrine/exocrine_gland_phen0.62503826
86MP0002653_abnormal_ependyma_morphology0.62114246
87MP0001485_abnormal_pinna_reflex0.61410589
88MP0002697_abnormal_eye_size0.58881982
89MP0003880_abnormal_central_pattern0.56499027
90MP0002080_prenatal_lethality0.54590702
91MP0004019_abnormal_vitamin_homeostasis0.53706694
92MP0000627_abnormal_mammary_gland0.52986940
93MP0004142_abnormal_muscle_tone0.50440046
94MP0003195_calcinosis0.50277312
95MP0002873_normal_phenotype0.50262908
96MP0002169_no_abnormal_phenotype0.50164295
97MP0003567_abnormal_fetal_cardiomyocyte0.48520686
98MP0000358_abnormal_cell_content/0.48331355
99MP0001919_abnormal_reproductive_system0.48210908
100MP0005197_abnormal_uvea_morphology0.47396346

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.81129469
2Congenital malformation of the right heart (HP:0011723)4.14011536
3Double outlet right ventricle (HP:0001719)4.14011536
4Premature ovarian failure (HP:0008209)3.96593317
5Short tibia (HP:0005736)3.84173718
6Abnormality of abdominal situs (HP:0011620)3.75179004
7Abdominal situs inversus (HP:0003363)3.75179004
8Aplasia/Hypoplasia of the tibia (HP:0005772)3.63260748
9Abnormality of the septum pellucidum (HP:0007375)3.60706954
10Septo-optic dysplasia (HP:0100842)3.60565866
11Posterior subcapsular cataract (HP:0007787)3.51600958
12Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.49980452
13Impulsivity (HP:0100710)3.39102949
14Patent foramen ovale (HP:0001655)3.35261519
15Carpal bone hypoplasia (HP:0001498)3.30996801
16Absent septum pellucidum (HP:0001331)3.21865615
17Abnormal pancreas size (HP:0012094)3.21463091
18Single umbilical artery (HP:0001195)3.16556865
19Abnormality of the fetal cardiovascular system (HP:0010948)3.16556865
20Abnormal umbilical cord blood vessels (HP:0011403)3.16556865
21Attenuation of retinal blood vessels (HP:0007843)3.14283632
22Rhinitis (HP:0012384)3.13288499
23Malnutrition (HP:0004395)3.12999567
24Hypophosphatemic rickets (HP:0004912)3.11529267
25Aplasia/hypoplasia of the uterus (HP:0008684)3.09830076
26Infertility (HP:0000789)3.09380819
27Preauricular pit (HP:0004467)3.04179058
28Periauricular skin pits (HP:0100277)3.04179058
29Abnormal ciliary motility (HP:0012262)2.97745032
30Birth length less than 3rd percentile (HP:0003561)2.90507217
31Meckel diverticulum (HP:0002245)2.82179407
32Abnormality of the preputium (HP:0100587)2.74762817
33Abnormality of the ileum (HP:0001549)2.72956589
34Subcapsular cataract (HP:0000523)2.72316124
35Facial cleft (HP:0002006)2.69420280
36Chromsome breakage (HP:0040012)2.64222679
37Aplasia/Hypoplasia involving the musculature (HP:0001460)2.63570612
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.62550265
39Absent/shortened dynein arms (HP:0200106)2.62550265
40Midline defect of the nose (HP:0004122)2.61936001
41Constricted visual fields (HP:0001133)2.61418830
42Abnormal rod and cone electroretinograms (HP:0008323)2.60298528
43Aplasia/hypoplasia of the humerus (HP:0006507)2.57833596
44Abnormality of the aortic arch (HP:0012303)2.56250088
45Reticulocytopenia (HP:0001896)2.56018707
46Myokymia (HP:0002411)2.55077280
47Azoospermia (HP:0000027)2.53439626
48Hypercortisolism (HP:0001578)2.53315656
49Bony spicule pigmentary retinopathy (HP:0007737)2.51347248
50Median cleft lip (HP:0000161)2.50841420
51Abnormal respiratory motile cilium physiology (HP:0012261)2.49209070
52Osteomalacia (HP:0002749)2.46148114
53Abnormal spermatogenesis (HP:0008669)2.42922176
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41041807
55Microretrognathia (HP:0000308)2.38484467
56Maternal diabetes (HP:0009800)2.36151635
57Ureteral duplication (HP:0000073)2.35955055
58Severe visual impairment (HP:0001141)2.33781981
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.33020165
60Abnormal respiratory motile cilium morphology (HP:0005938)2.31740572
61Abnormal respiratory epithelium morphology (HP:0012253)2.31740572
62Hypoplasia of the uterus (HP:0000013)2.30503633
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29105821
64Abnormal number of incisors (HP:0011064)2.23622263
65Absent radius (HP:0003974)2.23221030
66Hypoglycemic seizures (HP:0002173)2.23217854
67Supernumerary spleens (HP:0009799)2.21108883
68Absent thumb (HP:0009777)2.20425140
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19308741
70Sensory axonal neuropathy (HP:0003390)2.17319015
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16085913
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.14257695
73Abnormality of chromosome stability (HP:0003220)2.12699129
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12102935
75Skin pits (HP:0100276)2.11021892
76Glycosuria (HP:0003076)2.10233208
77Abnormality of urine glucose concentration (HP:0011016)2.10233208
78Optic nerve hypoplasia (HP:0000609)2.09199618
79Absent forearm bone (HP:0003953)2.08902630
80Aplasia involving forearm bones (HP:0009822)2.08902630
81Horseshoe kidney (HP:0000085)2.06327175
82Progressive sensorineural hearing impairment (HP:0000408)2.01780442
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.98184744
84Hypoplasia of the fovea (HP:0007750)1.98184744
85Fused cervical vertebrae (HP:0002949)1.97507192
86Glossoptosis (HP:0000162)1.93360225
87Stenosis of the external auditory canal (HP:0000402)1.90455253
88Tetraparesis (HP:0002273)1.90002922
89Cleft eyelid (HP:0000625)1.89835404
90Pendular nystagmus (HP:0012043)1.86610357
91Cortical visual impairment (HP:0100704)1.85462480
92Concave nail (HP:0001598)1.84962399
93Pancreatic cysts (HP:0001737)1.79279849
94Limb dystonia (HP:0002451)1.78946703
95Progressive hearing impairment (HP:0001730)1.78775069
96Retinal atrophy (HP:0001105)1.78389439
97Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77261556
98Dysphonia (HP:0001618)1.76961603
99Abnormality of the umbilical cord (HP:0010881)1.75438100
100Decreased central vision (HP:0007663)1.75426918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.53667954
2SRPK14.22232264
3LATS23.90983871
4TESK23.56259426
5PLK43.47468711
6STK163.44113792
7TRIM283.20006729
8CDK192.73841346
9NEK62.31441721
10PLK12.28322355
11DYRK32.26834873
12BRSK11.95796281
13TTK1.90694748
14TAOK31.89196991
15AURKA1.80798884
16CDC71.78494678
17PLK31.77320208
18CDK91.72035293
19MAP3K91.70364506
20TNIK1.69002688
21AURKB1.66980860
22ZAK1.64793639
23WNK11.59951874
24CDK121.52944318
25CDK71.42144417
26BRSK21.42015023
27NEK21.39951381
28WNK31.38041553
29TESK11.33509901
30PBK1.27052693
31PDK21.25796050
32MARK31.23665183
33CHEK11.22302591
34INSRR1.17888440
35VRK11.09110827
36CSNK1E1.03444695
37BRD41.02206636
38TLK10.98988336
39PIM20.98975165
40BMPR1B0.95148111
41CHEK20.94077669
42ATR0.89437801
43ACVR1B0.89096992
44PRKCI0.87077875
45CDK20.86753060
46GSK3A0.86273036
47MAP4K20.82368598
48NUAK10.82037772
49PKN10.81132366
50PIM10.80254721
51CSNK2A10.79105986
52CDK10.78085944
53MELK0.77260965
54CSNK2A20.74634820
55ATM0.72252441
56WEE10.71487214
57RAF10.71075278
58EIF2AK30.70271889
59PLK20.66871069
60MAPK130.66450744
61BRAF0.61887684
62CDK30.59592383
63STK30.57354614
64PRKG10.57208330
65DDR20.55597797
66PAK20.54450368
67MTOR0.54426955
68PRKACB0.53705434
69STK40.53394180
70STK390.51673667
71LRRK20.50348365
72MAP3K80.49175068
73GSK3B0.47990145
74MAP3K50.44880097
75PAK10.44344360
76MAPK10.43603322
77TSSK60.39760424
78TEC0.38893184
79RPS6KA10.38816371
80GRK10.38794936
81MAPK140.34397359
82CSNK1D0.33396834
83STK38L0.32792716
84CDK11A0.31921959
85PRKACA0.29831757
86MAP3K40.29435089
87PRKCE0.27783587
88AKT20.27453849
89KDR0.27201352
90PRKCG0.26759060
91DYRK1A0.26690425
92STK100.26240641
93EPHB20.25877479
94PRKD10.25754560
95CSNK1A10.25110849
96IRAK20.25098932
97NME10.24213878
98TIE10.20805900
99TBK10.20329547
100CAMK10.19759277

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.35523174
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.18477897
3Regulation of autophagy_Homo sapiens_hsa041403.50108797
4Ribosome_Homo sapiens_hsa030103.47216053
5RNA polymerase_Homo sapiens_hsa030203.32352561
6mRNA surveillance pathway_Homo sapiens_hsa030153.27034938
7RNA transport_Homo sapiens_hsa030133.17831814
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.82560915
9Spliceosome_Homo sapiens_hsa030402.66817023
10Cell cycle_Homo sapiens_hsa041102.65423644
11Oocyte meiosis_Homo sapiens_hsa041142.45204801
12Folate biosynthesis_Homo sapiens_hsa007902.40485499
13Homologous recombination_Homo sapiens_hsa034402.36044815
14p53 signaling pathway_Homo sapiens_hsa041152.25404241
15Mismatch repair_Homo sapiens_hsa034302.21885509
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.05984098
17Fanconi anemia pathway_Homo sapiens_hsa034602.05083440
18Taste transduction_Homo sapiens_hsa047421.85789525
19RNA degradation_Homo sapiens_hsa030181.76081563
20Caffeine metabolism_Homo sapiens_hsa002321.66671588
21Huntingtons disease_Homo sapiens_hsa050161.47407054
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.39143053
23Base excision repair_Homo sapiens_hsa034101.37270863
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33317708
25Olfactory transduction_Homo sapiens_hsa047401.30881472
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.27972670
27Pyrimidine metabolism_Homo sapiens_hsa002401.25743083
28Cardiac muscle contraction_Homo sapiens_hsa042601.24248059
29DNA replication_Homo sapiens_hsa030301.22224719
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19276918
31Dorso-ventral axis formation_Homo sapiens_hsa043201.17852244
32Purine metabolism_Homo sapiens_hsa002301.17723539
33Steroid biosynthesis_Homo sapiens_hsa001001.12673128
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12145797
35Sulfur metabolism_Homo sapiens_hsa009201.11515158
36Fatty acid elongation_Homo sapiens_hsa000621.00735230
37Parkinsons disease_Homo sapiens_hsa050121.00169212
38Fatty acid biosynthesis_Homo sapiens_hsa000610.96796984
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89276556
40Nucleotide excision repair_Homo sapiens_hsa034200.83465676
41Viral carcinogenesis_Homo sapiens_hsa052030.82792722
42Ovarian steroidogenesis_Homo sapiens_hsa049130.80744813
43Arginine and proline metabolism_Homo sapiens_hsa003300.80369175
44Inositol phosphate metabolism_Homo sapiens_hsa005620.78060636
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76499316
46Protein export_Homo sapiens_hsa030600.75747607
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75243398
48Non-homologous end-joining_Homo sapiens_hsa034500.72594180
49Insulin secretion_Homo sapiens_hsa049110.71735901
50Nicotine addiction_Homo sapiens_hsa050330.66744924
51Epstein-Barr virus infection_Homo sapiens_hsa051690.64853072
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61518822
53Wnt signaling pathway_Homo sapiens_hsa043100.61396983
54MicroRNAs in cancer_Homo sapiens_hsa052060.56201877
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55137260
56Oxidative phosphorylation_Homo sapiens_hsa001900.55050988
57Herpes simplex infection_Homo sapiens_hsa051680.54821106
58Proteasome_Homo sapiens_hsa030500.52450112
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52423579
60TGF-beta signaling pathway_Homo sapiens_hsa043500.51840667
61Alcoholism_Homo sapiens_hsa050340.48985193
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44926325
63Serotonergic synapse_Homo sapiens_hsa047260.42944331
64Systemic lupus erythematosus_Homo sapiens_hsa053220.42772490
65Bile secretion_Homo sapiens_hsa049760.39530664
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37905797
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.37806044
68GABAergic synapse_Homo sapiens_hsa047270.36822849
69Glutathione metabolism_Homo sapiens_hsa004800.36813654
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32499771
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32166571
72Retinol metabolism_Homo sapiens_hsa008300.31192640
73Metabolic pathways_Homo sapiens_hsa011000.30939446
74Calcium signaling pathway_Homo sapiens_hsa040200.29976392
75Amphetamine addiction_Homo sapiens_hsa050310.29513107
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28287080
77Hippo signaling pathway_Homo sapiens_hsa043900.27485624
78Protein digestion and absorption_Homo sapiens_hsa049740.27159414
79Phototransduction_Homo sapiens_hsa047440.26943733
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.25788043
81Hedgehog signaling pathway_Homo sapiens_hsa043400.24989394
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24253787
83Mineral absorption_Homo sapiens_hsa049780.23130064
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23065701
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22778705
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18934058
87Morphine addiction_Homo sapiens_hsa050320.18443781
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17712155
89AMPK signaling pathway_Homo sapiens_hsa041520.15411668
90Linoleic acid metabolism_Homo sapiens_hsa005910.13944852
91Hepatitis B_Homo sapiens_hsa051610.13635931
92cAMP signaling pathway_Homo sapiens_hsa040240.13561043
93Small cell lung cancer_Homo sapiens_hsa052220.10227533
94Chemical carcinogenesis_Homo sapiens_hsa052040.09273874
95ABC transporters_Homo sapiens_hsa020100.08291298
96Circadian entrainment_Homo sapiens_hsa047130.07190635
97Nitrogen metabolism_Homo sapiens_hsa009100.06715056
98Alzheimers disease_Homo sapiens_hsa050100.06362752
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06221505
100Legionellosis_Homo sapiens_hsa051340.05039018

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