ZNF675

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.49692571
2DNA double-strand break processing (GO:0000729)4.45373393
3L-fucose catabolic process (GO:0042355)3.85213786
4fucose catabolic process (GO:0019317)3.85213786
5L-fucose metabolic process (GO:0042354)3.85213786
6neural tube formation (GO:0001841)3.75055762
7indolalkylamine metabolic process (GO:0006586)3.57319269
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56667675
9regulation of nuclear cell cycle DNA replication (GO:0033262)3.51184154
10indole-containing compound catabolic process (GO:0042436)3.50985687
11indolalkylamine catabolic process (GO:0046218)3.50985687
12tryptophan catabolic process (GO:0006569)3.50985687
13response to pheromone (GO:0019236)3.48276513
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.40613754
15kynurenine metabolic process (GO:0070189)3.38176262
16replication fork processing (GO:0031297)3.37215426
17rRNA catabolic process (GO:0016075)3.33309235
18centriole replication (GO:0007099)3.28323574
19negative regulation of translation, ncRNA-mediated (GO:0040033)3.28268169
20regulation of translation, ncRNA-mediated (GO:0045974)3.28268169
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28268169
22piRNA metabolic process (GO:0034587)3.21541163
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.21537799
24recombinational repair (GO:0000725)3.17864115
25double-strand break repair via homologous recombination (GO:0000724)3.15287382
26DNA deamination (GO:0045006)3.09515852
27epithelial cilium movement (GO:0003351)3.07710230
28regulation of DNA endoreduplication (GO:0032875)3.07284028
29reciprocal DNA recombination (GO:0035825)3.06428033
30reciprocal meiotic recombination (GO:0007131)3.06428033
31RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05387653
32protein K11-linked deubiquitination (GO:0035871)3.05046155
33tryptophan metabolic process (GO:0006568)3.02258314
34somite development (GO:0061053)3.00208760
35microtubule depolymerization (GO:0007019)2.98711121
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95013759
37regulation of mitotic spindle checkpoint (GO:1903504)2.95013759
38water-soluble vitamin biosynthetic process (GO:0042364)2.93766714
39axoneme assembly (GO:0035082)2.93053707
40synapsis (GO:0007129)2.91000082
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84564202
42mitochondrial respiratory chain complex I assembly (GO:0032981)2.84564202
43NADH dehydrogenase complex assembly (GO:0010257)2.84564202
44prenylation (GO:0097354)2.84119143
45protein prenylation (GO:0018342)2.84119143
46pyrimidine nucleobase catabolic process (GO:0006208)2.82751793
47nonmotile primary cilium assembly (GO:0035058)2.82707387
48cilium or flagellum-dependent cell motility (GO:0001539)2.82519132
49ncRNA catabolic process (GO:0034661)2.81974446
50meiotic chromosome segregation (GO:0045132)2.78863749
51respiratory chain complex IV assembly (GO:0008535)2.74942285
52detection of light stimulus involved in visual perception (GO:0050908)2.74700984
53detection of light stimulus involved in sensory perception (GO:0050962)2.74700984
54regulation of gene silencing by RNA (GO:0060966)2.74654487
55regulation of posttranscriptional gene silencing (GO:0060147)2.74654487
56regulation of gene silencing by miRNA (GO:0060964)2.74654487
57protein polyglutamylation (GO:0018095)2.72344113
58chromatin remodeling at centromere (GO:0031055)2.71905640
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71662904
60negative regulation of telomere maintenance (GO:0032205)2.67841557
61cilium organization (GO:0044782)2.67661727
62DNA methylation involved in gamete generation (GO:0043046)2.67144963
63microtubule anchoring (GO:0034453)2.66705891
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66468103
65male meiosis I (GO:0007141)2.66254273
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65777420
67male meiosis (GO:0007140)2.65494712
68platelet dense granule organization (GO:0060155)2.65325011
69cilium morphogenesis (GO:0060271)2.65073252
70photoreceptor cell maintenance (GO:0045494)2.64153608
71cilium movement (GO:0003341)2.62999757
72DNA replication checkpoint (GO:0000076)2.62997359
73regulation of mesoderm development (GO:2000380)2.61543243
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.61310914
75somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61310914
76regulation of hippo signaling (GO:0035330)2.60359741
77regulation of meiosis I (GO:0060631)2.60284254
78intraciliary transport (GO:0042073)2.60101137
79protein complex biogenesis (GO:0070271)2.59967229
80cilium assembly (GO:0042384)2.59142072
81regulation of telomere maintenance (GO:0032204)2.56145122
82protein-cofactor linkage (GO:0018065)2.55736373
83retinal cone cell development (GO:0046549)2.54744863
84CENP-A containing nucleosome assembly (GO:0034080)2.54736102
85kidney morphogenesis (GO:0060993)2.53845238
86indole-containing compound metabolic process (GO:0042430)2.53516636
87mitochondrial respiratory chain complex assembly (GO:0033108)2.52221824
88DNA demethylation (GO:0080111)2.48905545
89microtubule polymerization or depolymerization (GO:0031109)2.48899637
90positive regulation of oligodendrocyte differentiation (GO:0048714)2.48610837
91neuron fate determination (GO:0048664)2.48134644
92resolution of meiotic recombination intermediates (GO:0000712)2.48133681
93photoreceptor cell development (GO:0042461)2.46976927
94atrial cardiac muscle cell action potential (GO:0086014)2.46657003
95regulation of centriole replication (GO:0046599)2.46473384
96head development (GO:0060322)2.45760733
97postreplication repair (GO:0006301)2.44138847
98negative regulation of mast cell activation (GO:0033004)2.44112907
99histone exchange (GO:0043486)2.43386426
100establishment of protein localization to Golgi (GO:0072600)2.42586647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.89092117
2VDR_22108803_ChIP-Seq_LS180_Human3.40285306
3IGF1R_20145208_ChIP-Seq_DFB_Human2.87604819
4GBX2_23144817_ChIP-Seq_PC3_Human2.82827669
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.76840593
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64056979
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63474804
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61480094
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57214275
10EWS_26573619_Chip-Seq_HEK293_Human2.49917737
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47140149
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45275975
13TAF15_26573619_Chip-Seq_HEK293_Human2.32628221
14FUS_26573619_Chip-Seq_HEK293_Human2.29564184
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.29004134
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18020178
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15825980
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15605332
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12148063
20P300_19829295_ChIP-Seq_ESCs_Human2.10512722
21EZH2_22144423_ChIP-Seq_EOC_Human1.95594293
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.93922604
23ER_23166858_ChIP-Seq_MCF-7_Human1.82553099
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78271670
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.77318121
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75440503
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74138655
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71913481
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.70796946
30IRF1_19129219_ChIP-ChIP_H3396_Human1.65671490
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65282699
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62394679
33ELK1_19687146_ChIP-ChIP_HELA_Human1.60782201
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59709600
35* STAT3_23295773_ChIP-Seq_U87_Human1.55725536
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55491535
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55148905
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54952850
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54265448
40CBP_20019798_ChIP-Seq_JUKART_Human1.54265448
41* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51493725
42SMAD4_21799915_ChIP-Seq_A2780_Human1.47885703
43* MYC_18940864_ChIP-ChIP_HL60_Human1.46836457
44* BCAT_22108803_ChIP-Seq_LS180_Human1.45982724
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45348701
46TP53_22573176_ChIP-Seq_HFKS_Human1.44663822
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.43854774
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43600558
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.43133708
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40779675
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39367500
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38027012
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38027012
54TCF4_23295773_ChIP-Seq_U87_Human1.37274347
55* VDR_23849224_ChIP-Seq_CD4+_Human1.37221397
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35576636
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35451599
58AR_25329375_ChIP-Seq_VCAP_Human1.34532051
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33372233
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.32563510
61RNF2_27304074_Chip-Seq_NSC_Mouse1.30975706
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27867425
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27024574
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26758932
65AR_21572438_ChIP-Seq_LNCaP_Human1.25067736
66* TCF4_22108803_ChIP-Seq_LS180_Human1.23833524
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.23485104
68NANOG_19829295_ChIP-Seq_ESCs_Human1.23387712
69SOX2_19829295_ChIP-Seq_ESCs_Human1.23387712
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.22610489
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22097464
72RUNX2_22187159_ChIP-Seq_PCA_Human1.21859219
73* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21268669
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19830491
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.16871617
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14397328
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.13845252
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.13495287
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12409343
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12160888
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09476464
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.08679811
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07839754
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.07627386
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07627386
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.06962960
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04993908
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.03959437
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03010677
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02025503
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00891545
92NCOR_22424771_ChIP-Seq_293T_Human1.00203790
93REST_21632747_ChIP-Seq_MESCs_Mouse0.99004203
94P53_22387025_ChIP-Seq_ESCs_Mouse0.97334329
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96351628
96* HOXB7_26014856_ChIP-Seq_BT474_Human0.95750473
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94595702
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91596834
99AR_20517297_ChIP-Seq_VCAP_Human0.91416411
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.90931510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.48674187
2MP0008057_abnormal_DNA_replication2.88698854
3MP0000569_abnormal_digit_pigmentation2.86226260
4MP0002102_abnormal_ear_morphology2.85948275
5MP0003890_abnormal_embryonic-extraembry2.50094382
6MP0006292_abnormal_olfactory_placode2.46722437
7MP0008058_abnormal_DNA_repair2.35982343
8MP0005551_abnormal_eye_electrophysiolog2.28342032
9MP0003136_yellow_coat_color2.22817885
10MP0003787_abnormal_imprinting2.18503658
11MP0003195_calcinosis2.16524949
12MP0002736_abnormal_nociception_after2.04906571
13MP0001968_abnormal_touch/_nociception1.98712822
14MP0006072_abnormal_retinal_apoptosis1.96148044
15MP0005253_abnormal_eye_physiology1.86309892
16MP0003880_abnormal_central_pattern1.75849206
17MP0009046_muscle_twitch1.73838658
18MP0010094_abnormal_chromosome_stability1.71630960
19MP0006276_abnormal_autonomic_nervous1.69453426
20MP0001529_abnormal_vocalization1.66725912
21MP0003646_muscle_fatigue1.62987466
22MP0008872_abnormal_physiological_respon1.60599793
23MP0004142_abnormal_muscle_tone1.60539581
24MP0000427_abnormal_hair_cycle1.60494522
25MP0000631_abnormal_neuroendocrine_gland1.60188773
26MP0001986_abnormal_taste_sensitivity1.58120474
27MP0005646_abnormal_pituitary_gland1.56207194
28MP0002638_abnormal_pupillary_reflex1.53155366
29MP0002938_white_spotting1.51651288
30MP0009745_abnormal_behavioral_response1.49771587
31MP0003718_maternal_effect1.43834709
32MP0004133_heterotaxia1.43583393
33MP0002234_abnormal_pharynx_morphology1.42389505
34MP0005084_abnormal_gallbladder_morpholo1.40511126
35MP0001485_abnormal_pinna_reflex1.37597599
36MP0001984_abnormal_olfaction1.34985071
37MP0008875_abnormal_xenobiotic_pharmacok1.32407747
38MP0000372_irregular_coat_pigmentation1.32276551
39MP0004043_abnormal_pH_regulation1.31918728
40MP0008789_abnormal_olfactory_epithelium1.30833684
41MP0008995_early_reproductive_senescence1.30726723
42MP0002272_abnormal_nervous_system1.29758200
43MP0004885_abnormal_endolymph1.28975990
44MP0000778_abnormal_nervous_system1.28362252
45MP0001486_abnormal_startle_reflex1.26788497
46MP0005645_abnormal_hypothalamus_physiol1.26068705
47MP0005499_abnormal_olfactory_system1.24282085
48MP0005394_taste/olfaction_phenotype1.24282085
49MP0005174_abnormal_tail_pigmentation1.23818899
50MP0003693_abnormal_embryo_hatching1.23655683
51MP0003119_abnormal_digestive_system1.22076789
52MP0002735_abnormal_chemical_nociception1.21751695
53MP0002751_abnormal_autonomic_nervous1.21664486
54MP0002653_abnormal_ependyma_morphology1.21529151
55MP0005389_reproductive_system_phenotype1.21307675
56MP0003011_delayed_dark_adaptation1.21100977
57MP0001293_anophthalmia1.18112249
58MP0002210_abnormal_sex_determination1.17336135
59MP0003121_genomic_imprinting1.17018087
60MP0001929_abnormal_gametogenesis1.16917928
61MP0002160_abnormal_reproductive_system1.15528935
62MP0001188_hyperpigmentation1.15393887
63MP0002928_abnormal_bile_duct1.14936348
64MP0001919_abnormal_reproductive_system1.12981577
65MP0001501_abnormal_sleep_pattern1.12804753
66MP0003937_abnormal_limbs/digits/tail_de1.10185689
67MP0003698_abnormal_male_reproductive1.09451223
68MP0000383_abnormal_hair_follicle1.08768842
69MP0004147_increased_porphyrin_level1.07709976
70MP0004742_abnormal_vestibular_system1.07586021
71MP0002572_abnormal_emotion/affect_behav1.06088208
72MP0004924_abnormal_behavior1.02813882
73MP0005386_behavior/neurological_phenoty1.02813882
74MP0002557_abnormal_social/conspecific_i1.02360636
75MP0002837_dystrophic_cardiac_calcinosis1.02309990
76MP0002067_abnormal_sensory_capabilities1.01703063
77MP0003567_abnormal_fetal_cardiomyocyte0.99557101
78MP0005423_abnormal_somatic_nervous0.98965431
79MP0005195_abnormal_posterior_eye0.98175572
80MP0000653_abnormal_sex_gland0.97350030
81MP0001145_abnormal_male_reproductive0.97059548
82MP0005391_vision/eye_phenotype0.95056069
83MP0001324_abnormal_eye_pigmentation0.93009943
84MP0000647_abnormal_sebaceous_gland0.91891362
85MP0002752_abnormal_somatic_nervous0.90566132
86MP0005075_abnormal_melanosome_morpholog0.89833601
87MP0002095_abnormal_skin_pigmentation0.89641432
88MP0002064_seizures0.83759939
89MP0000049_abnormal_middle_ear0.83753834
90MP0001764_abnormal_homeostasis0.83037714
91MP0002163_abnormal_gland_morphology0.82724427
92MP0002184_abnormal_innervation0.81786532
93MP0003137_abnormal_impulse_conducting0.81277471
94MP0004215_abnormal_myocardial_fiber0.81194134
95MP0003635_abnormal_synaptic_transmissio0.80116446
96MP0002063_abnormal_learning/memory/cond0.79403123
97MP0005187_abnormal_penis_morphology0.79112005
98MP0002876_abnormal_thyroid_physiology0.79071896
99MP0001970_abnormal_pain_threshold0.78481909
100MP0004145_abnormal_muscle_electrophysio0.78417324

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.08221252
2True hermaphroditism (HP:0010459)3.79266076
3Molar tooth sign on MRI (HP:0002419)3.56681209
4Abnormality of midbrain morphology (HP:0002418)3.56681209
5Pancreatic fibrosis (HP:0100732)3.49843075
6Congenital stationary night blindness (HP:0007642)3.35871415
7Nephronophthisis (HP:0000090)3.22495139
8Abnormality of the labia minora (HP:0012880)3.19273157
9Chronic hepatic failure (HP:0100626)2.94591531
10Hyperventilation (HP:0002883)2.89708399
11Abnormality of the renal medulla (HP:0100957)2.83775387
12Birth length less than 3rd percentile (HP:0003561)2.74206812
13Medial flaring of the eyebrow (HP:0010747)2.73691912
14Abnormality of the renal cortex (HP:0011035)2.72616804
15Attenuation of retinal blood vessels (HP:0007843)2.56534608
16Abolished electroretinogram (ERG) (HP:0000550)2.52830008
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50250314
18Abnormality of alanine metabolism (HP:0010916)2.50250314
19Hyperalaninemia (HP:0003348)2.50250314
20Colon cancer (HP:0003003)2.47029824
21Type II lissencephaly (HP:0007260)2.43393631
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.42253938
23Progressive inability to walk (HP:0002505)2.37411897
24Inability to walk (HP:0002540)2.36874973
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.33677543
26Pendular nystagmus (HP:0012043)2.31520974
27Patellar aplasia (HP:0006443)2.31065700
28Protruding tongue (HP:0010808)2.28874755
29Lissencephaly (HP:0001339)2.27944488
30Cystic liver disease (HP:0006706)2.26923287
31Gait imbalance (HP:0002141)2.26234787
32Gaze-evoked nystagmus (HP:0000640)2.25586080
33Stomach cancer (HP:0012126)2.25247752
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.23324341
35Absent/shortened dynein arms (HP:0200106)2.23324341
36Volvulus (HP:0002580)2.20625620
37Congenital primary aphakia (HP:0007707)2.20071144
38Abnormality of the ileum (HP:0001549)2.18998543
39Renal cortical cysts (HP:0000803)2.18169929
40Abnormality of the pons (HP:0007361)2.18110986
41Aplasia/Hypoplasia of the patella (HP:0006498)2.17683356
42Abnormal rod and cone electroretinograms (HP:0008323)2.15537376
43Genetic anticipation (HP:0003743)2.14875033
44Progressive cerebellar ataxia (HP:0002073)2.13966301
45Meckel diverticulum (HP:0002245)2.13928143
46Nephrogenic diabetes insipidus (HP:0009806)2.13611604
47Hypoplasia of the pons (HP:0012110)2.10573312
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.06660260
49Broad-based gait (HP:0002136)2.04931650
50Male pseudohermaphroditism (HP:0000037)2.03612416
51Sclerocornea (HP:0000647)2.03206547
52Anencephaly (HP:0002323)2.02531003
53Genital tract atresia (HP:0001827)2.00039790
54Intestinal atresia (HP:0011100)1.99595731
55Small hand (HP:0200055)1.98795480
56Oligodactyly (hands) (HP:0001180)1.97006167
57Abnormal drinking behavior (HP:0030082)1.96597428
58Polydipsia (HP:0001959)1.96597428
59Abnormality of chromosome stability (HP:0003220)1.96437733
60Bile duct proliferation (HP:0001408)1.95142439
61Abnormal biliary tract physiology (HP:0012439)1.95142439
62Febrile seizures (HP:0002373)1.93094339
63Vaginal atresia (HP:0000148)1.92789099
64Sloping forehead (HP:0000340)1.90340394
65Bony spicule pigmentary retinopathy (HP:0007737)1.89936755
66Optic nerve hypoplasia (HP:0000609)1.88646521
67Abnormal respiratory motile cilium morphology (HP:0005938)1.88501020
68Abnormal respiratory epithelium morphology (HP:0012253)1.88501020
69Methylmalonic acidemia (HP:0002912)1.87109190
70Tubular atrophy (HP:0000092)1.86912252
71Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86688545
72Short tibia (HP:0005736)1.85807793
73Postaxial foot polydactyly (HP:0001830)1.85699561
74Ectopic kidney (HP:0000086)1.85400183
75Chorioretinal atrophy (HP:0000533)1.83333286
76Retinal dysplasia (HP:0007973)1.81934760
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81034030
78Cerebellar dysplasia (HP:0007033)1.80728282
79Hyperglycinemia (HP:0002154)1.80395193
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80232459
81Fair hair (HP:0002286)1.79725322
82Abnormal ciliary motility (HP:0012262)1.79093038
83Chromsome breakage (HP:0040012)1.78213212
84Dandy-Walker malformation (HP:0001305)1.77608240
85Atonic seizures (HP:0010819)1.76005406
86Hyperglycinuria (HP:0003108)1.75621611
87Poor coordination (HP:0002370)1.75175794
883-Methylglutaconic aciduria (HP:0003535)1.75044325
89Large for gestational age (HP:0001520)1.74594703
90Congenital hepatic fibrosis (HP:0002612)1.74325033
91Tubulointerstitial nephritis (HP:0001970)1.73523039
92Hypothermia (HP:0002045)1.72889136
93Postaxial hand polydactyly (HP:0001162)1.72509246
94Supernumerary spleens (HP:0009799)1.70821345
95Preaxial hand polydactyly (HP:0001177)1.68762029
96Furrowed tongue (HP:0000221)1.67679552
97Pachygyria (HP:0001302)1.66507694
98Astigmatism (HP:0000483)1.66285604
99Aplasia/hypoplasia of the uterus (HP:0008684)1.66024601
100Increased corneal curvature (HP:0100692)1.65945627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.00751182
2ACVR1B2.94943593
3WNK32.91785659
4ZAK2.69545275
5BMPR1B2.65555379
6NUAK12.51614543
7MAP4K22.36791115
8PINK12.29043543
9CASK2.28339296
10ADRBK22.25834173
11MKNK22.13971227
12BRSK21.93402540
13TRIM281.91660109
14GRK11.82147494
15INSRR1.80914106
16TNIK1.79834324
17MAP3K41.68916685
18MAPK131.68102184
19TAOK31.63589637
20WNK41.58871721
21WEE11.55696802
22PLK41.54055116
23TLK11.50802743
24ERBB31.36771080
25MKNK11.36200870
26PNCK1.31683720
27STK161.25249130
28CAMKK21.23217241
29CDC71.22305031
30VRK11.20881998
31DYRK21.19226989
32OXSR11.19212842
33SRPK11.17842475
34BCR1.16157657
35STK391.13119858
36PLK31.11729058
37MARK11.05829176
38TSSK61.03741314
39PAK31.01032606
40EIF2AK30.99327235
41TXK0.98646705
42BUB10.91967211
43PLK20.90603070
44EPHA40.88150949
45CSNK1G20.87333831
46TGFBR10.86652819
47CSNK1G10.86561519
48MAP2K70.85029882
49STK38L0.82487290
50NLK0.80969830
51NEK20.80855721
52DAPK20.79653298
53TEC0.77697631
54PLK10.76090973
55BRD40.76036964
56CSNK1A1L0.74702953
57PRKCG0.74485338
58PRKCE0.74131995
59DYRK30.73026170
60CSNK1G30.72320878
61ATR0.72143023
62BCKDK0.70726855
63NTRK30.68743249
64ADRBK10.68346125
65AKT30.66532461
66PIK3CA0.65609680
67RPS6KA50.64866660
68CCNB10.62060376
69CHEK20.61678932
70FGFR20.57458992
71SGK20.56242278
72STK30.56041443
73MAPK150.55611457
74MST40.55394857
75ATM0.54303944
76NTRK20.53958732
77NEK10.48899227
78RPS6KA40.47146892
79PRKCQ0.44693944
80IRAK10.43034691
81PKN10.42631176
82CSNK1A10.42177945
83CSNK1D0.40504163
84CAMK2A0.39748616
85CDK30.38310977
86CDK190.36691478
87TTK0.36629760
88DYRK1A0.35975743
89MUSK0.35883256
90LATS10.35281738
91EIF2AK20.33353876
92SGK4940.32611480
93SGK2230.32611480
94CAMK10.32577135
95PRKACA0.32299986
96BRSK10.32283815
97TIE10.32195153
98PASK0.31398327
99ITK0.30114643
100MAPKAPK50.29713653

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.83394356
2Phototransduction_Homo sapiens_hsa047442.64972500
3Fanconi anemia pathway_Homo sapiens_hsa034602.62650512
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33544495
5Basal transcription factors_Homo sapiens_hsa030222.32577865
6Nicotine addiction_Homo sapiens_hsa050332.26373688
7Butanoate metabolism_Homo sapiens_hsa006502.20700791
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17159323
9Protein export_Homo sapiens_hsa030602.10928381
10RNA polymerase_Homo sapiens_hsa030202.08896016
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05808573
12Linoleic acid metabolism_Homo sapiens_hsa005912.05291051
13Selenocompound metabolism_Homo sapiens_hsa004502.04094438
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03178107
15RNA degradation_Homo sapiens_hsa030181.95714588
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95081719
17Non-homologous end-joining_Homo sapiens_hsa034501.94756514
18Nitrogen metabolism_Homo sapiens_hsa009101.89693785
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85425513
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84120953
21Caffeine metabolism_Homo sapiens_hsa002321.80080666
22Propanoate metabolism_Homo sapiens_hsa006401.77665054
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77654812
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74622335
25Tryptophan metabolism_Homo sapiens_hsa003801.59103893
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55969920
27Ether lipid metabolism_Homo sapiens_hsa005651.50911729
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47717455
29Mismatch repair_Homo sapiens_hsa034301.42549304
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39752364
31One carbon pool by folate_Homo sapiens_hsa006701.38660466
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36525824
33Taste transduction_Homo sapiens_hsa047421.35264178
34Oxidative phosphorylation_Homo sapiens_hsa001901.29718289
35RNA transport_Homo sapiens_hsa030131.29577739
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28333737
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.24752275
38Olfactory transduction_Homo sapiens_hsa047401.19922395
39Steroid biosynthesis_Homo sapiens_hsa001001.19876895
40Peroxisome_Homo sapiens_hsa041461.19104837
41Regulation of autophagy_Homo sapiens_hsa041401.16145035
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.14328670
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11278713
44ABC transporters_Homo sapiens_hsa020101.04566847
45Nucleotide excision repair_Homo sapiens_hsa034201.02088125
46Morphine addiction_Homo sapiens_hsa050321.01177557
47Parkinsons disease_Homo sapiens_hsa050120.96339623
48DNA replication_Homo sapiens_hsa030300.95774377
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.95635287
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91734444
51Chemical carcinogenesis_Homo sapiens_hsa052040.90932100
52Retinol metabolism_Homo sapiens_hsa008300.88485479
53Serotonergic synapse_Homo sapiens_hsa047260.84454550
54Huntingtons disease_Homo sapiens_hsa050160.83084068
55Purine metabolism_Homo sapiens_hsa002300.82519378
56GABAergic synapse_Homo sapiens_hsa047270.81615929
57Primary immunodeficiency_Homo sapiens_hsa053400.78789199
58Base excision repair_Homo sapiens_hsa034100.78634910
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.77522733
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76686220
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75643199
62Cell cycle_Homo sapiens_hsa041100.72096694
63Circadian entrainment_Homo sapiens_hsa047130.72017850
64Dorso-ventral axis formation_Homo sapiens_hsa043200.71568776
65Glutamatergic synapse_Homo sapiens_hsa047240.70070970
66Proteasome_Homo sapiens_hsa030500.69660038
67beta-Alanine metabolism_Homo sapiens_hsa004100.69547270
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68751844
69Spliceosome_Homo sapiens_hsa030400.67509321
70Pyrimidine metabolism_Homo sapiens_hsa002400.66990262
71mRNA surveillance pathway_Homo sapiens_hsa030150.66923022
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65177983
73Glycerolipid metabolism_Homo sapiens_hsa005610.63342296
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63106363
75Hedgehog signaling pathway_Homo sapiens_hsa043400.60089098
76Lysine degradation_Homo sapiens_hsa003100.58851192
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58581371
78Circadian rhythm_Homo sapiens_hsa047100.58302475
79Arachidonic acid metabolism_Homo sapiens_hsa005900.57034387
80p53 signaling pathway_Homo sapiens_hsa041150.56282135
81Metabolic pathways_Homo sapiens_hsa011000.55744212
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.54468899
83Insulin secretion_Homo sapiens_hsa049110.48394807
84Basal cell carcinoma_Homo sapiens_hsa052170.46703387
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46263127
86Calcium signaling pathway_Homo sapiens_hsa040200.46136985
87Oocyte meiosis_Homo sapiens_hsa041140.44921464
88Ovarian steroidogenesis_Homo sapiens_hsa049130.44786102
89Vitamin digestion and absorption_Homo sapiens_hsa049770.43202491
90Salivary secretion_Homo sapiens_hsa049700.43094057
91Alcoholism_Homo sapiens_hsa050340.41589271
92Dopaminergic synapse_Homo sapiens_hsa047280.40237146
93Systemic lupus erythematosus_Homo sapiens_hsa053220.40217364
94Alzheimers disease_Homo sapiens_hsa050100.39938279
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39686977
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39519500
97Amphetamine addiction_Homo sapiens_hsa050310.37434853
98Histidine metabolism_Homo sapiens_hsa003400.37278792
99Cardiac muscle contraction_Homo sapiens_hsa042600.35305558
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34613687

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