ZNF658B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of glycoprotein biosynthetic process (GO:0010560)5.62244881
2mitotic sister chromatid cohesion (GO:0007064)5.31690488
3interkinetic nuclear migration (GO:0022027)5.13626196
4regulation of protein glycosylation (GO:0060049)5.02569596
5regulation of Rac protein signal transduction (GO:0035020)4.86375232
6gonadal mesoderm development (GO:0007506)4.58539148
7misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.49774438
8limb bud formation (GO:0060174)4.29729429
9positive regulation of glycoprotein metabolic process (GO:1903020)4.22011527
10energy homeostasis (GO:0097009)4.13626698
11regulation of meiosis I (GO:0060631)4.10222929
12autophagic vacuole fusion (GO:0000046)3.92330999
13inner mitochondrial membrane organization (GO:0007007)3.86687886
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85915883
15keratinocyte development (GO:0003334)3.82827857
16amino-acid betaine metabolic process (GO:0006577)3.79456733
17carnitine metabolic process (GO:0009437)3.71126031
18piRNA metabolic process (GO:0034587)3.69347348
19otic vesicle formation (GO:0030916)3.68707628
20regulation of male gonad development (GO:2000018)3.65781264
21positive regulation of male gonad development (GO:2000020)3.60396466
22appendage development (GO:0048736)3.53290998
23limb development (GO:0060173)3.53290998
24histone mRNA catabolic process (GO:0071044)3.51174221
25organelle membrane fusion (GO:0090174)3.46825431
26activation of Rac GTPase activity (GO:0032863)3.45773567
27Golgi to endosome transport (GO:0006895)3.41297588
28L-fucose catabolic process (GO:0042355)3.40557813
29fucose catabolic process (GO:0019317)3.40557813
30L-fucose metabolic process (GO:0042354)3.40557813
31nucleus localization (GO:0051647)3.40529427
32artery smooth muscle contraction (GO:0014824)3.29777351
33regulation of establishment of cell polarity (GO:2000114)3.29036245
34phasic smooth muscle contraction (GO:0014821)3.22156472
35retinal ganglion cell axon guidance (GO:0031290)3.17025053
36cerebral cortex radially oriented cell migration (GO:0021799)3.14653347
37ganglion development (GO:0061548)3.14121070
38epithelial cilium movement (GO:0003351)3.07428400
39innervation (GO:0060384)3.07390003
40intraciliary transport (GO:0042073)3.01687465
41protein K11-linked deubiquitination (GO:0035871)2.97835146
42cilium movement (GO:0003341)2.95973171
43microtubule nucleation (GO:0007020)2.95850098
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92638087
45respiratory chain complex IV assembly (GO:0008535)2.92480865
46male meiosis I (GO:0007141)2.90743672
47cilium morphogenesis (GO:0060271)2.90621398
48lactate metabolic process (GO:0006089)2.88453151
49magnesium ion transport (GO:0015693)2.88098799
50male meiosis (GO:0007140)2.86497972
51neural tube formation (GO:0001841)2.85748470
52somite rostral/caudal axis specification (GO:0032525)2.82898107
53regulation of establishment or maintenance of cell polarity (GO:0032878)2.82758926
54sister chromatid cohesion (GO:0007062)2.81898736
55positive regulation of meiosis (GO:0045836)2.81220300
56kidney morphogenesis (GO:0060993)2.79259914
57polyol catabolic process (GO:0046174)2.77724712
58negative regulation of JUN kinase activity (GO:0043508)2.77278465
59vascular smooth muscle contraction (GO:0014829)2.76718911
60inner ear receptor cell development (GO:0060119)2.71839537
61cytochrome complex assembly (GO:0017004)2.68565480
62cytoplasmic microtubule organization (GO:0031122)2.68464347
63basic amino acid transport (GO:0015802)2.66995919
64diterpenoid biosynthetic process (GO:0016102)2.66527270
65tonic smooth muscle contraction (GO:0014820)2.66449735
66cell morphogenesis involved in neuron differentiation (GO:0048667)2.65646613
67aggressive behavior (GO:0002118)2.65007839
68thyroid hormone metabolic process (GO:0042403)2.63576907
69proline transport (GO:0015824)2.62587126
70inner ear receptor stereocilium organization (GO:0060122)2.61695709
71prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.61620994
72smoothened signaling pathway (GO:0007224)2.60370587
73acrosome reaction (GO:0007340)2.60369003
74prostate gland growth (GO:0060736)2.59270807
75gene silencing by RNA (GO:0031047)2.59086106
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58511795
77positive regulation of meiotic cell cycle (GO:0051446)2.57247954
78regulation of timing of cell differentiation (GO:0048505)2.56029786
79oxidative demethylation (GO:0070989)2.54722029
80somite development (GO:0061053)2.53025615
81negative regulation of potassium ion transmembrane transport (GO:1901380)2.51813207
82presynaptic membrane assembly (GO:0097105)2.49335720
83histone H3-K4 trimethylation (GO:0080182)2.49195773
84regulation of microtubule-based movement (GO:0060632)2.48382312
85cilium organization (GO:0044782)2.47275461
86neuron fate determination (GO:0048664)2.46801166
87terpenoid biosynthetic process (GO:0016114)2.46012735
88fructose metabolic process (GO:0006000)2.45945483
89regulation of cilium movement (GO:0003352)2.45634786
90DNA unwinding involved in DNA replication (GO:0006268)2.45465363
91centriole replication (GO:0007099)2.45214915
92cilium assembly (GO:0042384)2.45051238
93negative regulation of Ras GTPase activity (GO:0034261)2.44989783
94negative regulation of epidermal cell differentiation (GO:0045605)2.38877354
95inositol phosphate catabolic process (GO:0071545)2.38033421
96type B pancreatic cell proliferation (GO:0044342)2.37805073
97olfactory bulb development (GO:0021772)2.36678451
98hindbrain development (GO:0030902)2.35119818
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35084620
100regulation of translation, ncRNA-mediated (GO:0045974)2.35084620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.49624988
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.87735987
3VDR_22108803_ChIP-Seq_LS180_Human3.65255217
4IGF1R_20145208_ChIP-Seq_DFB_Human3.16381837
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.11208644
6GBX2_23144817_ChIP-Seq_PC3_Human2.75438607
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73131127
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60037253
9FUS_26573619_Chip-Seq_HEK293_Human2.59201710
10ZNF274_21170338_ChIP-Seq_K562_Hela2.59106177
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57311076
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33777152
13P300_19829295_ChIP-Seq_ESCs_Human2.28579309
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.20473383
15ER_23166858_ChIP-Seq_MCF-7_Human2.20357666
16TAF15_26573619_Chip-Seq_HEK293_Human2.19502305
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17857863
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.13809918
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11956363
20EWS_26573619_Chip-Seq_HEK293_Human1.94504433
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93878295
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93375902
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88844576
24BCAT_22108803_ChIP-Seq_LS180_Human1.84419821
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.80836070
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.79150924
27SMAD4_21799915_ChIP-Seq_A2780_Human1.75722438
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73013977
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72864446
30STAT3_23295773_ChIP-Seq_U87_Human1.70301172
31* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69099748
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68953315
33AR_25329375_ChIP-Seq_VCAP_Human1.67111370
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61280696
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.58181146
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55402963
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52772616
38TCF4_22108803_ChIP-Seq_LS180_Human1.51068889
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50748365
40CBP_20019798_ChIP-Seq_JUKART_Human1.50748365
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50243317
42TCF4_23295773_ChIP-Seq_U87_Human1.48524672
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47193850
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45941342
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44843063
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44843063
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41370630
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.40933677
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39013866
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.38923219
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38849639
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38849639
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.38758639
54RUNX2_22187159_ChIP-Seq_PCA_Human1.36823489
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35719008
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35583253
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35535100
58E2F7_22180533_ChIP-Seq_HELA_Human1.35486987
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34989826
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30050558
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29542062
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.28754234
63P53_22387025_ChIP-Seq_ESCs_Mouse1.28378505
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.25675726
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.25571828
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23150359
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.19723145
68RNF2_27304074_Chip-Seq_NSC_Mouse1.18247886
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17341165
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14400904
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.14270394
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14268000
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.13416897
74KDM2B_26808549_Chip-Seq_REH_Human1.12261092
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.12211424
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11665116
77P300_18555785_Chip-Seq_ESCs_Mouse1.11466938
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.10101105
79SOX9_26525672_Chip-Seq_HEART_Mouse1.08723511
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08247041
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07938792
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07763889
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06752095
84SOX2_19829295_ChIP-Seq_ESCs_Human1.06617900
85NANOG_19829295_ChIP-Seq_ESCs_Human1.06617900
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.05878027
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05596999
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05232211
89AHR_22903824_ChIP-Seq_MCF-7_Human1.03044942
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.02371981
91TBL1_22424771_ChIP-Seq_293T_Human1.02258933
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.01442970
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00324859
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.00128156
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99281779
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99056503
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98289749
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97219045
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97083875
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95564774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.24933044
2MP0003787_abnormal_imprinting3.62364498
3MP0003123_paternal_imprinting3.45365311
4MP0008877_abnormal_DNA_methylation3.24073344
5MP0002938_white_spotting3.03658023
6MP0003121_genomic_imprinting2.79980667
7MP0000647_abnormal_sebaceous_gland2.50996956
8MP0005379_endocrine/exocrine_gland_phen2.31405009
9MP0006292_abnormal_olfactory_placode2.23195176
10MP0005187_abnormal_penis_morphology2.20555977
11MP0005174_abnormal_tail_pigmentation2.16477048
12MP0005253_abnormal_eye_physiology2.02270724
13MP0004215_abnormal_myocardial_fiber2.00364659
14MP0008995_early_reproductive_senescence1.94404383
15MP0005248_abnormal_Harderian_gland1.92248171
16MP0002837_dystrophic_cardiac_calcinosis1.90871546
17MP0003122_maternal_imprinting1.84429227
18MP0000427_abnormal_hair_cycle1.72760006
19MP0002653_abnormal_ependyma_morphology1.71148629
20MP0006072_abnormal_retinal_apoptosis1.67304903
21MP0003890_abnormal_embryonic-extraembry1.65414802
22MP0008058_abnormal_DNA_repair1.56875304
23MP0001986_abnormal_taste_sensitivity1.52602546
24MP0002638_abnormal_pupillary_reflex1.45731830
25MP0005551_abnormal_eye_electrophysiolog1.44044090
26MP0002163_abnormal_gland_morphology1.41138778
27MP0003136_yellow_coat_color1.39167096
28MP0003786_premature_aging1.39102328
29MP0008789_abnormal_olfactory_epithelium1.39063749
30MP0002254_reproductive_system_inflammat1.38968194
31MP0003119_abnormal_digestive_system1.37913392
32MP0002557_abnormal_social/conspecific_i1.36302958
33MP0006054_spinal_hemorrhage1.35689570
34MP0002102_abnormal_ear_morphology1.34279121
35MP0002095_abnormal_skin_pigmentation1.33412329
36MP0005647_abnormal_sex_gland1.30018369
37MP0000383_abnormal_hair_follicle1.25832460
38MP0001529_abnormal_vocalization1.25356250
39MP0009697_abnormal_copulation1.21698294
40MP0002909_abnormal_adrenal_gland1.20227049
41MP0000778_abnormal_nervous_system1.18046968
42MP0004145_abnormal_muscle_electrophysio1.17016511
43MP0000372_irregular_coat_pigmentation1.16545913
44MP0000516_abnormal_urinary_system1.16127993
45MP0005367_renal/urinary_system_phenotyp1.16127993
46MP0006035_abnormal_mitochondrial_morpho1.15405154
47MP0001984_abnormal_olfaction1.14044673
48MP0004885_abnormal_endolymph1.13230096
49MP0003880_abnormal_central_pattern1.08751894
50MP0000613_abnormal_salivary_gland1.06010847
51MP0000631_abnormal_neuroendocrine_gland1.04677119
52MP0002751_abnormal_autonomic_nervous1.02556746
53MP0005391_vision/eye_phenotype1.01609567
54MP0009703_decreased_birth_body1.01528518
55MP0009046_muscle_twitch0.98047019
56MP0001929_abnormal_gametogenesis0.95556940
57MP0002971_abnormal_brown_adipose0.92209574
58MP0000566_synostosis0.91794247
59MP0010352_gastrointestinal_tract_polyps0.91494441
60MP0004084_abnormal_cardiac_muscle0.90705907
61MP0003698_abnormal_male_reproductive0.90318211
62MP0004270_analgesia0.88800713
63MP0010678_abnormal_skin_adnexa0.87604621
64MP0005646_abnormal_pituitary_gland0.87057019
65MP0000653_abnormal_sex_gland0.86880411
66MP0003755_abnormal_palate_morphology0.84918678
67MP0005386_behavior/neurological_phenoty0.83848639
68MP0004924_abnormal_behavior0.83848639
69MP0002127_abnormal_cardiovascular_syste0.83198050
70MP0002067_abnormal_sensory_capabilities0.82332770
71MP0002736_abnormal_nociception_after0.82031166
72MP0004197_abnormal_fetal_growth/weight/0.81886541
73MP0008057_abnormal_DNA_replication0.81431491
74MP0001968_abnormal_touch/_nociception0.80191924
75MP0002572_abnormal_emotion/affect_behav0.79625741
76MP0005075_abnormal_melanosome_morpholog0.79192624
77MP0002272_abnormal_nervous_system0.79172885
78MP0005394_taste/olfaction_phenotype0.79001829
79MP0005499_abnormal_olfactory_system0.79001829
80MP0002210_abnormal_sex_determination0.78671702
81MP0006138_congestive_heart_failure0.78359240
82MP0001188_hyperpigmentation0.77468829
83MP0001486_abnormal_startle_reflex0.76618685
84MP0001145_abnormal_male_reproductive0.75571594
85MP0003315_abnormal_perineum_morphology0.73727389
86MP0003937_abnormal_limbs/digits/tail_de0.73547820
87MP0010307_abnormal_tumor_latency0.73518901
88MP0004043_abnormal_pH_regulation0.72895708
89MP0010368_abnormal_lymphatic_system0.72867783
90MP0004134_abnormal_chest_morphology0.72651764
91MP0010094_abnormal_chromosome_stability0.72596357
92MP0001346_abnormal_lacrimal_gland0.70591663
93MP0002109_abnormal_limb_morphology0.69982156
94MP0005195_abnormal_posterior_eye0.69356336
95MP0001944_abnormal_pancreas_morphology0.67000311
96MP0008775_abnormal_heart_ventricle0.66751248
97MP0001177_atelectasis0.65863783
98MP0002233_abnormal_nose_morphology0.65649060
99MP0008875_abnormal_xenobiotic_pharmacok0.65326838
100MP0002277_abnormal_respiratory_mucosa0.64087959

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.55422645
2True hermaphroditism (HP:0010459)3.26939294
3Molar tooth sign on MRI (HP:0002419)3.20780410
4Abnormality of midbrain morphology (HP:0002418)3.20780410
5Congenital stationary night blindness (HP:0007642)3.16897480
6Intestinal atresia (HP:0011100)3.11616772
7Hypothermia (HP:0002045)3.09742328
8Pancreatic cysts (HP:0001737)3.05053441
9Hypoplasia of the pons (HP:0012110)2.99123954
10Chromsome breakage (HP:0040012)2.96165532
11Hepatoblastoma (HP:0002884)2.92893021
12Pancreatic fibrosis (HP:0100732)2.92296004
13Papillary thyroid carcinoma (HP:0002895)2.88111724
14Type II lissencephaly (HP:0007260)2.86254132
15Diastasis recti (HP:0001540)2.84885801
16Abnormality of the pons (HP:0007361)2.76689970
17White forelock (HP:0002211)2.70366019
18Cerebellar dysplasia (HP:0007033)2.65475680
19Medial flaring of the eyebrow (HP:0010747)2.64855662
20Nephronophthisis (HP:0000090)2.64403475
21Esophageal atresia (HP:0002032)2.64169494
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57586039
23Sclerocornea (HP:0000647)2.53860566
24Abnormality of the labia minora (HP:0012880)2.52800659
25Patchy hypopigmentation of hair (HP:0011365)2.52389371
26Gastrointestinal atresia (HP:0002589)2.51925210
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51867297
28Abnormality of chromosome stability (HP:0003220)2.49822513
29Medulloblastoma (HP:0002885)2.48860521
30Volvulus (HP:0002580)2.45333742
31Neuroendocrine neoplasm (HP:0100634)2.43243128
32Absent eyebrow (HP:0002223)2.40484780
33Disproportionate short-trunk short stature (HP:0003521)2.38109778
34Drooling (HP:0002307)2.36247032
35Abnormality of the renal cortex (HP:0011035)2.30702241
36Abnormal ciliary motility (HP:0012262)2.29739383
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.28304367
38Thyroid carcinoma (HP:0002890)2.27322964
39Broad-based gait (HP:0002136)2.26355010
40Gait imbalance (HP:0002141)2.26320168
41Congenital primary aphakia (HP:0007707)2.23382619
42Vaginal atresia (HP:0000148)2.18926991
43Genital tract atresia (HP:0001827)2.18692193
44Aqueductal stenosis (HP:0002410)2.17047743
45Focal motor seizures (HP:0011153)2.16548858
46Barrel-shaped chest (HP:0001552)2.16512435
47Glioma (HP:0009733)2.16130023
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.15137458
49Absent/shortened dynein arms (HP:0200106)2.15137458
50Male pseudohermaphroditism (HP:0000037)2.13812579
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13206720
52Excessive salivation (HP:0003781)2.12948449
53Abnormality of abdominal situs (HP:0011620)2.10921914
54Abdominal situs inversus (HP:0003363)2.10921914
55Dyskinesia (HP:0100660)2.09791230
56Abnormal rod and cone electroretinograms (HP:0008323)2.08275368
57Blue irides (HP:0000635)2.07331253
58Neoplasm of the adrenal cortex (HP:0100641)2.06613751
59Abnormal respiratory epithelium morphology (HP:0012253)2.06569156
60Abnormal respiratory motile cilium morphology (HP:0005938)2.06569156
61Adrenal hypoplasia (HP:0000835)2.06046495
62Hyperglycinuria (HP:0003108)2.02395677
63Cystic liver disease (HP:0006706)2.01842488
64Preaxial hand polydactyly (HP:0001177)2.01277684
65Abnormal biliary tract morphology (HP:0012440)2.00934757
66Flat capital femoral epiphysis (HP:0003370)2.00109662
67Narrow forehead (HP:0000341)1.99144221
68Progressive cerebellar ataxia (HP:0002073)1.96330299
69Abnormality of renal excretion (HP:0011036)1.96232848
70Abnormality of the renal medulla (HP:0100957)1.95269682
71Oligodactyly (hands) (HP:0001180)1.94110559
72High anterior hairline (HP:0009890)1.93281124
73Aplasia/Hypoplasia of the nipples (HP:0006709)1.92701961
74Dialeptic seizures (HP:0011146)1.90491321
75Tented upper lip vermilion (HP:0010804)1.90233777
7611 pairs of ribs (HP:0000878)1.89936276
77Abnormality of the antihelix (HP:0009738)1.87425286
78Potter facies (HP:0002009)1.86606948
79Facial shape deformation (HP:0011334)1.86606948
80Absent speech (HP:0001344)1.86325012
81Absence seizures (HP:0002121)1.85678903
82Broad nasal tip (HP:0000455)1.85242566
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.84659936
84Nephrogenic diabetes insipidus (HP:0009806)1.84271464
85Astigmatism (HP:0000483)1.82134928
86Widely patent fontanelles and sutures (HP:0004492)1.81494037
87Abnormal sex determination (HP:0012244)1.79497637
88Sex reversal (HP:0012245)1.79497637
89Tubular atrophy (HP:0000092)1.79411101
90Abnormal respiratory motile cilium physiology (HP:0012261)1.79121694
91Pheochromocytoma (HP:0002666)1.76144601
92Abnormality of permanent molar morphology (HP:0011071)1.76131218
93Abnormality of the dental root (HP:0006486)1.76131218
94Taurodontia (HP:0000679)1.76131218
95Small hand (HP:0200055)1.73830938
96Abnormality of the dental pulp (HP:0006479)1.71460550
97Postaxial hand polydactyly (HP:0001162)1.70634307
98Specific learning disability (HP:0001328)1.70618724
99Biliary tract neoplasm (HP:0100574)1.70129142
100Optic nerve hypoplasia (HP:0000609)1.69654434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L4.79955326
2FRK4.15841195
3NEK93.75255276
4BRSK22.95852770
5PNCK2.91709185
6MKNK22.80229793
7CDK192.75740958
8MAP3K42.61146976
9CASK2.58569534
10ACVR1B2.42332105
11GRK12.34539416
12MAP2K71.82316934
13FGFR21.72967144
14WNK11.72854296
15OBSCN1.70945887
16PTK2B1.62539740
17WNK41.47140810
18WEE11.46258258
19MKNK11.41966921
20MAP3K61.35520945
21CAMK1G1.33463209
22OXSR11.32826517
23PLK21.32292867
24ERBB31.28247408
25PAK31.24772182
26MAPK131.24722286
27IRAK21.23738147
28YES11.20225622
29MAP2K41.18312013
30MAPK151.17160762
31EPHA41.15503320
32IRAK11.15071089
33CDC71.12276448
34CAMKK21.10192381
35BRSK11.09241911
36PINK11.09005307
37MAP4K21.08986499
38BCR1.05963885
39ADRBK21.04857138
40STK241.03629238
41VRK11.03517676
42CSNK1G21.03338358
43WNK30.99629702
44NEK10.96593981
45PHKG10.93298137
46PHKG20.93298137
47PLK40.92116430
48ROCK10.91072923
49PRKCE0.90464091
50PLK30.84682203
51NTRK20.82831169
52TRIM280.79674797
53FGFR30.78145156
54STK380.77622595
55CSNK1G10.77521969
56BLK0.77341336
57CSNK1G30.74577201
58BMPR1B0.74277768
59NUAK10.72935916
60CAMK1D0.72934548
61MARK10.72473709
62FER0.67654923
63STK390.67569906
64TGFBR10.61706514
65PRKAA20.60615135
66SGK20.59071098
67ATM0.58606872
68TIE10.58039695
69MUSK0.57739961
70ERBB20.57633058
71PASK0.57112357
72TSSK60.55306988
73PRKCG0.53783259
74MAP3K70.53400882
75AKT30.50817713
76PLK10.50694852
77PRKDC0.49941828
78FGFR10.48779813
79MET0.48755550
80RPS6KB10.48504741
81PIK3CA0.48202426
82STK30.48031839
83NTRK30.47707330
84CSNK1D0.47102405
85DYRK20.46252949
86PRKG10.45538906
87PKN10.41810501
88CAMK2A0.40587898
89INSRR0.39456014
90UHMK10.39368752
91DYRK1A0.38486380
92MAP3K20.38171665
93CDK30.38008367
94DAPK20.37644106
95CAMK10.34478998
96DMPK0.34110652
97CAMK40.33709946
98PRKCZ0.31367069
99PIK3CG0.30064904
100EIF2AK30.29633015

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.75139567
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.67048841
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.52834359
4Fatty acid biosynthesis_Homo sapiens_hsa000612.33190705
5Non-homologous end-joining_Homo sapiens_hsa034502.11028171
6Dorso-ventral axis formation_Homo sapiens_hsa043201.92916202
7Circadian rhythm_Homo sapiens_hsa047101.91777651
8Propanoate metabolism_Homo sapiens_hsa006401.89975084
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89269048
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86337942
11Phototransduction_Homo sapiens_hsa047441.81314353
12Steroid biosynthesis_Homo sapiens_hsa001001.79318568
13Nicotine addiction_Homo sapiens_hsa050331.76175071
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.69486323
15Fatty acid degradation_Homo sapiens_hsa000711.69340731
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64111332
17Fatty acid metabolism_Homo sapiens_hsa012121.63057307
18Fanconi anemia pathway_Homo sapiens_hsa034601.60805454
19Caffeine metabolism_Homo sapiens_hsa002321.54497966
20Protein export_Homo sapiens_hsa030601.51909502
21Tryptophan metabolism_Homo sapiens_hsa003801.51750463
22Homologous recombination_Homo sapiens_hsa034401.47230485
23Lysine degradation_Homo sapiens_hsa003101.44860497
24Butanoate metabolism_Homo sapiens_hsa006501.44562520
25Taste transduction_Homo sapiens_hsa047421.42821096
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41990443
27Serotonergic synapse_Homo sapiens_hsa047261.41623332
28Morphine addiction_Homo sapiens_hsa050321.39737105
29Regulation of autophagy_Homo sapiens_hsa041401.39282655
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38323958
31GABAergic synapse_Homo sapiens_hsa047271.37737236
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34320073
33Dopaminergic synapse_Homo sapiens_hsa047281.33991249
34Hedgehog signaling pathway_Homo sapiens_hsa043401.33497401
35Histidine metabolism_Homo sapiens_hsa003401.33255026
36Basal transcription factors_Homo sapiens_hsa030221.32441064
37Renin-angiotensin system_Homo sapiens_hsa046141.25950732
38beta-Alanine metabolism_Homo sapiens_hsa004101.25384133
39Circadian entrainment_Homo sapiens_hsa047131.22070630
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21872251
41Insulin secretion_Homo sapiens_hsa049111.20112075
42Nitrogen metabolism_Homo sapiens_hsa009101.11206177
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10095796
44Renin secretion_Homo sapiens_hsa049241.07560941
45Cocaine addiction_Homo sapiens_hsa050301.05690456
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05025932
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03826745
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97992586
49Glutamatergic synapse_Homo sapiens_hsa047240.97769283
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97140090
51Amphetamine addiction_Homo sapiens_hsa050310.95240451
52Long-term depression_Homo sapiens_hsa047300.93146698
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92722632
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88136398
55Retinol metabolism_Homo sapiens_hsa008300.82823443
56ABC transporters_Homo sapiens_hsa020100.82112973
57Wnt signaling pathway_Homo sapiens_hsa043100.80799262
58Oocyte meiosis_Homo sapiens_hsa041140.80709803
59Chemical carcinogenesis_Homo sapiens_hsa052040.77679747
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77186586
61RNA degradation_Homo sapiens_hsa030180.74822283
62Peroxisome_Homo sapiens_hsa041460.70257504
63cAMP signaling pathway_Homo sapiens_hsa040240.66255293
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61093844
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60709435
66Salivary secretion_Homo sapiens_hsa049700.58917330
67Cholinergic synapse_Homo sapiens_hsa047250.57376419
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57254203
69Calcium signaling pathway_Homo sapiens_hsa040200.57139272
70DNA replication_Homo sapiens_hsa030300.56900097
71Type II diabetes mellitus_Homo sapiens_hsa049300.56242262
72Sphingolipid metabolism_Homo sapiens_hsa006000.55984452
73Starch and sucrose metabolism_Homo sapiens_hsa005000.55715085
74TGF-beta signaling pathway_Homo sapiens_hsa043500.52881068
75AMPK signaling pathway_Homo sapiens_hsa041520.51878945
76Linoleic acid metabolism_Homo sapiens_hsa005910.51740615
77Thyroid hormone synthesis_Homo sapiens_hsa049180.51478660
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50640432
79Basal cell carcinoma_Homo sapiens_hsa052170.50219592
80Glycerolipid metabolism_Homo sapiens_hsa005610.50082410
81Pyruvate metabolism_Homo sapiens_hsa006200.49829665
82Oxytocin signaling pathway_Homo sapiens_hsa049210.49503650
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49078297
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48886813
85RNA transport_Homo sapiens_hsa030130.48529982
86Olfactory transduction_Homo sapiens_hsa047400.48256724
87Tight junction_Homo sapiens_hsa045300.48232846
88Hippo signaling pathway_Homo sapiens_hsa043900.47956016
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47507133
90Cardiac muscle contraction_Homo sapiens_hsa042600.46490575
91Axon guidance_Homo sapiens_hsa043600.44921562
92Fatty acid elongation_Homo sapiens_hsa000620.44919162
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44875862
94Folate biosynthesis_Homo sapiens_hsa007900.43155795
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41612180
96Nucleotide excision repair_Homo sapiens_hsa034200.41563033
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38364912
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37617345
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37608929
100Arginine and proline metabolism_Homo sapiens_hsa003300.36322777

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