ZNF658

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)4.62639449
2protein polyglutamylation (GO:0018095)3.99383307
3intraciliary transport (GO:0042073)3.85294750
4DNA integration (GO:0015074)3.74264999
5nonmotile primary cilium assembly (GO:0035058)3.39855954
6fucose catabolic process (GO:0019317)3.37478607
7L-fucose metabolic process (GO:0042354)3.37478607
8L-fucose catabolic process (GO:0042355)3.37478607
9neural tube formation (GO:0001841)3.33278253
10DNA double-strand break processing (GO:0000729)3.32666435
11regulation of meiosis I (GO:0060631)3.26924871
12G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25174782
13seminiferous tubule development (GO:0072520)3.21900983
14regulation of action potential (GO:0098900)3.14495467
15regulation of sarcomere organization (GO:0060297)3.12528499
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11482531
17retinal cone cell development (GO:0046549)3.05814948
18regulation of relaxation of muscle (GO:1901077)3.00618503
19protein K11-linked deubiquitination (GO:0035871)2.99884608
20interkinetic nuclear migration (GO:0022027)2.99395335
21cellular ketone body metabolic process (GO:0046950)2.98826052
22detection of light stimulus involved in visual perception (GO:0050908)2.98465862
23detection of light stimulus involved in sensory perception (GO:0050962)2.98465862
24epithelial cilium movement (GO:0003351)2.95698872
25pyrimidine nucleobase catabolic process (GO:0006208)2.94252790
26regulation of cilium movement (GO:0003352)2.93123587
27regulation of male gonad development (GO:2000018)2.91119018
28axoneme assembly (GO:0035082)2.90634077
29cilium morphogenesis (GO:0060271)2.90463447
30branched-chain amino acid catabolic process (GO:0009083)2.88420005
31cilium organization (GO:0044782)2.87045749
32lactate metabolic process (GO:0006089)2.78833758
33cilium assembly (GO:0042384)2.78423166
34ketone body metabolic process (GO:1902224)2.76867934
35cilium movement (GO:0003341)2.75552719
36protein localization to cilium (GO:0061512)2.75261109
37indolalkylamine metabolic process (GO:0006586)2.75187807
38acrosome reaction (GO:0007340)2.73593086
39photoreceptor cell maintenance (GO:0045494)2.73060811
40regulation of cell communication by electrical coupling (GO:0010649)2.71911268
41positive regulation of male gonad development (GO:2000020)2.68796029
42reflex (GO:0060004)2.68530405
43tryptophan metabolic process (GO:0006568)2.66778060
44positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.66723620
45mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.66723620
46indole-containing compound catabolic process (GO:0042436)2.66144232
47indolalkylamine catabolic process (GO:0046218)2.66144232
48tryptophan catabolic process (GO:0006569)2.66144232
49inositol phosphate catabolic process (GO:0071545)2.65896238
50regulation of telomere maintenance (GO:0032204)2.65569868
51Golgi to endosome transport (GO:0006895)2.64933234
52somite rostral/caudal axis specification (GO:0032525)2.64727705
53presynaptic membrane assembly (GO:0097105)2.64458084
54positive regulation of dendritic spine morphogenesis (GO:0061003)2.63626979
55transepithelial transport (GO:0070633)2.61574387
56retinal ganglion cell axon guidance (GO:0031290)2.61559836
57response to pheromone (GO:0019236)2.58756217
58response to nitrosative stress (GO:0051409)2.57704188
59limb bud formation (GO:0060174)2.56696281
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56379015
61piRNA metabolic process (GO:0034587)2.55724275
62central nervous system neuron axonogenesis (GO:0021955)2.55214886
63preassembly of GPI anchor in ER membrane (GO:0016254)2.54532313
64polyol catabolic process (GO:0046174)2.54294987
65female gonad development (GO:0008585)2.52886560
66acrosome assembly (GO:0001675)2.52569198
67neurotransmitter-gated ion channel clustering (GO:0072578)2.48679113
68central nervous system projection neuron axonogenesis (GO:0021952)2.48461644
69glycosphingolipid biosynthetic process (GO:0006688)2.48154794
70prenylation (GO:0097354)2.46831198
71protein prenylation (GO:0018342)2.46831198
72aggressive behavior (GO:0002118)2.46084466
73cellular component assembly involved in morphogenesis (GO:0010927)2.45396390
74positive regulation of glycolytic process (GO:0045821)2.43242418
75tachykinin receptor signaling pathway (GO:0007217)2.42509702
76regulation of Rac protein signal transduction (GO:0035020)2.42028711
77positive regulation of cell size (GO:0045793)2.41622141
78nucleobase catabolic process (GO:0046113)2.40735979
79kynurenine metabolic process (GO:0070189)2.40529390
80regulation of keratinocyte proliferation (GO:0010837)2.39112782
81regulation of dendritic spine morphogenesis (GO:0061001)2.38035451
82establishment of protein localization to Golgi (GO:0072600)2.37107872
83regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.36531967
84cilium or flagellum-dependent cell motility (GO:0001539)2.35819331
85respiratory chain complex IV assembly (GO:0008535)2.35113433
86retinal rod cell development (GO:0046548)2.33996711
87left/right axis specification (GO:0070986)2.31583542
88negative regulation of neurological system process (GO:0031645)2.31293654
89cornea development in camera-type eye (GO:0061303)2.30454061
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.30079363
91behavioral response to ethanol (GO:0048149)2.28857916
92artery development (GO:0060840)2.27872786
93pyrimidine dimer repair (GO:0006290)2.27065024
94platelet dense granule organization (GO:0060155)2.26627313
95short-term memory (GO:0007614)2.26163932
96histone mRNA catabolic process (GO:0071044)2.25978732
97inner ear receptor stereocilium organization (GO:0060122)2.25906558
98embryonic epithelial tube formation (GO:0001838)2.23854401
99protein targeting to vacuole (GO:0006623)2.23810429
100establishment of protein localization to vacuole (GO:0072666)2.23810429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.70304779
2GBX2_23144817_ChIP-Seq_PC3_Human3.40012423
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.17273879
4ZNF274_21170338_ChIP-Seq_K562_Hela3.11148890
5IGF1R_20145208_ChIP-Seq_DFB_Human3.03979310
6ZFP57_27257070_Chip-Seq_ESCs_Mouse3.02556270
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90523205
8FUS_26573619_Chip-Seq_HEK293_Human2.70556765
9VDR_22108803_ChIP-Seq_LS180_Human2.51849210
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45232985
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34260173
12EWS_26573619_Chip-Seq_HEK293_Human2.33950179
13TAF15_26573619_Chip-Seq_HEK293_Human2.26333274
14P300_19829295_ChIP-Seq_ESCs_Human2.26060037
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.23312326
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13586379
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05000572
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.94353828
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86326282
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84238619
21ER_23166858_ChIP-Seq_MCF-7_Human1.83043639
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82080847
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81531641
24SMAD4_21799915_ChIP-Seq_A2780_Human1.76871641
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.74115412
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73958527
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71641912
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70301573
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.70300778
30* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68283299
31* CBP_20019798_ChIP-Seq_JUKART_Human1.68283299
32STAT3_23295773_ChIP-Seq_U87_Human1.65083917
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63813131
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63786909
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62165922
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.60036007
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56180088
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56180088
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54526876
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54422761
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54171660
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51790490
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51477210
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48651921
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.48503307
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.47033646
47TCF4_23295773_ChIP-Seq_U87_Human1.44139278
48BCAT_22108803_ChIP-Seq_LS180_Human1.44004644
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41957996
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40986596
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40967145
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36452340
53IRF1_19129219_ChIP-ChIP_H3396_Human1.36025711
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34867115
55AR_25329375_ChIP-Seq_VCAP_Human1.34116390
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.34028395
57P53_22387025_ChIP-Seq_ESCs_Mouse1.32322272
58* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32280672
59NANOG_19829295_ChIP-Seq_ESCs_Human1.31588118
60SOX2_19829295_ChIP-Seq_ESCs_Human1.31588118
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31333711
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.31272661
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.30190120
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29005187
65TCF4_22108803_ChIP-Seq_LS180_Human1.28376324
66RUNX2_22187159_ChIP-Seq_PCA_Human1.26688181
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25953663
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25953663
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25878992
70ELK1_19687146_ChIP-ChIP_HELA_Human1.23951961
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.23664767
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21908891
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21761076
74RNF2_27304074_Chip-Seq_NSC_Mouse1.21450521
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.21051883
76CDX2_22108803_ChIP-Seq_LS180_Human1.20497213
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.20126072
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18766962
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15948843
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15910413
81P300_18555785_Chip-Seq_ESCs_Mouse1.15444286
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12571622
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.10850214
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.08732219
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07996179
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07899412
87SOX2_18555785_Chip-Seq_ESCs_Mouse1.07784514
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04391873
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.03632678
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03434168
91TP53_22573176_ChIP-Seq_HFKS_Human1.03079318
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02959370
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01784582
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01496357
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00312219
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99709414
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.99111120
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.99082240
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.98711410
100KDM2B_26808549_Chip-Seq_REH_Human0.98459972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence3.15283610
2MP0000569_abnormal_digit_pigmentation3.13541347
3MP0002102_abnormal_ear_morphology3.11837383
4MP0000516_abnormal_urinary_system3.07611457
5MP0005367_renal/urinary_system_phenotyp3.07611457
6MP0008877_abnormal_DNA_methylation2.79783260
7MP0000372_irregular_coat_pigmentation2.58133714
8MP0001984_abnormal_olfaction2.46269967
9MP0006054_spinal_hemorrhage2.28568271
10MP0003315_abnormal_perineum_morphology1.96480084
11MP0003195_calcinosis1.93531286
12MP0003121_genomic_imprinting1.89311761
13MP0008789_abnormal_olfactory_epithelium1.84368617
14MP0004215_abnormal_myocardial_fiber1.83133140
15MP0005187_abnormal_penis_morphology1.81101487
16MP0003786_premature_aging1.79814616
17MP0005551_abnormal_eye_electrophysiolog1.78204658
18MP0003221_abnormal_cardiomyocyte_apopto1.77026304
19MP0000537_abnormal_urethra_morphology1.74379129
20MP0005253_abnormal_eye_physiology1.69713575
21MP0002638_abnormal_pupillary_reflex1.67299791
22MP0003880_abnormal_central_pattern1.65514226
23MP0008057_abnormal_DNA_replication1.63145774
24MP0003567_abnormal_fetal_cardiomyocyte1.61400755
25MP0009046_muscle_twitch1.60295620
26MP0001529_abnormal_vocalization1.58967968
27MP0003890_abnormal_embryonic-extraembry1.58458454
28MP0006072_abnormal_retinal_apoptosis1.57163296
29MP0003122_maternal_imprinting1.50765660
30MP0001486_abnormal_startle_reflex1.45121571
31MP0006276_abnormal_autonomic_nervous1.44579638
32MP0008058_abnormal_DNA_repair1.36381039
33MP0002233_abnormal_nose_morphology1.35351668
34MP0003787_abnormal_imprinting1.34617106
35MP0000427_abnormal_hair_cycle1.33554413
36MP0005645_abnormal_hypothalamus_physiol1.33542740
37MP0004133_heterotaxia1.33216170
38MP0003950_abnormal_plasma_membrane1.33050889
39MP0004270_analgesia1.31671679
40MP0000647_abnormal_sebaceous_gland1.27807672
41MP0005084_abnormal_gallbladder_morpholo1.26909112
42MP0002837_dystrophic_cardiac_calcinosis1.26155350
43MP0005499_abnormal_olfactory_system1.25535532
44MP0005394_taste/olfaction_phenotype1.25535532
45MP0002735_abnormal_chemical_nociception1.24771289
46MP0008872_abnormal_physiological_respon1.24350509
47MP0008961_abnormal_basal_metabolism1.20129350
48MP0003119_abnormal_digestive_system1.18138676
49MP0002736_abnormal_nociception_after1.12931434
50MP0006035_abnormal_mitochondrial_morpho1.12711897
51MP0000613_abnormal_salivary_gland1.12527642
52MP0000383_abnormal_hair_follicle1.12067818
53MP0010386_abnormal_urinary_bladder1.10516228
54MP0004484_altered_response_of1.09421867
55MP0009697_abnormal_copulation1.07845761
56MP0000778_abnormal_nervous_system1.05997603
57MP0003943_abnormal_hepatobiliary_system1.05620361
58MP0004043_abnormal_pH_regulation1.05332760
59MP0000631_abnormal_neuroendocrine_gland1.05244244
60MP0005647_abnormal_sex_gland1.04946933
61MP0002653_abnormal_ependyma_morphology1.02808859
62MP0005386_behavior/neurological_phenoty0.98563641
63MP0004924_abnormal_behavior0.98563641
64MP0003937_abnormal_limbs/digits/tail_de0.97337151
65MP0001968_abnormal_touch/_nociception0.96093915
66MP0005171_absent_coat_pigmentation0.93926668
67MP0001501_abnormal_sleep_pattern0.93890637
68MP0002938_white_spotting0.92852245
69MP0002254_reproductive_system_inflammat0.92425834
70MP0004085_abnormal_heartbeat0.92059487
71MP0005195_abnormal_posterior_eye0.89583265
72MP0003698_abnormal_male_reproductive0.88830670
73MP0009703_decreased_birth_body0.88764592
74MP0003718_maternal_effect0.88019838
75MP0001177_atelectasis0.87332338
76MP0004885_abnormal_endolymph0.87085291
77MP0002168_other_aberrant_phenotype0.84928814
78MP0003646_muscle_fatigue0.83775865
79MP0002160_abnormal_reproductive_system0.83588460
80MP0001986_abnormal_taste_sensitivity0.82150951
81MP0005174_abnormal_tail_pigmentation0.81939691
82MP0000653_abnormal_sex_gland0.81871418
83MP0003011_delayed_dark_adaptation0.81329765
84MP0003755_abnormal_palate_morphology0.81128367
85MP0002090_abnormal_vision0.79392818
86MP0002572_abnormal_emotion/affect_behav0.79083770
87MP0001661_extended_life_span0.79047858
88MP0006292_abnormal_olfactory_placode0.78990557
89MP0001929_abnormal_gametogenesis0.77887947
90MP0002557_abnormal_social/conspecific_i0.77841942
91MP0005395_other_phenotype0.77033458
92MP0005391_vision/eye_phenotype0.76457943
93MP0002067_abnormal_sensory_capabilities0.76311478
94MP0004142_abnormal_muscle_tone0.75668222
95MP0002751_abnormal_autonomic_nervous0.74878040
96MP0005620_abnormal_muscle_contractility0.74800913
97MP0002752_abnormal_somatic_nervous0.74417877
98MP0001286_abnormal_eye_development0.73956413
99MP0000639_abnormal_adrenal_gland0.73613920
100MP0002272_abnormal_nervous_system0.73462652

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.84461831
2Medial flaring of the eyebrow (HP:0010747)3.80770467
3Pancreatic cysts (HP:0001737)3.68674723
4Abnormality of midbrain morphology (HP:0002418)3.42869074
5Molar tooth sign on MRI (HP:0002419)3.42869074
6Congenital primary aphakia (HP:0007707)3.23499368
7Gait imbalance (HP:0002141)3.22354651
8Pancreatic fibrosis (HP:0100732)3.18416698
9Nephrogenic diabetes insipidus (HP:0009806)3.04071429
10Hyperventilation (HP:0002883)2.99857715
11Progressive inability to walk (HP:0002505)2.94691923
12Nephronophthisis (HP:0000090)2.92353965
13Genital tract atresia (HP:0001827)2.85429389
14Vaginal atresia (HP:0000148)2.78751208
15Intestinal atresia (HP:0011100)2.68096437
16Abnormality of the renal cortex (HP:0011035)2.62272165
17Febrile seizures (HP:0002373)2.55402862
18Abnormality of the renal medulla (HP:0100957)2.55372537
19Dyskinesia (HP:0100660)2.54489869
20Male pseudohermaphroditism (HP:0000037)2.54177225
21Drooling (HP:0002307)2.53195372
22Absent speech (HP:0001344)2.52338624
23Broad-based gait (HP:0002136)2.49996744
24Type II lissencephaly (HP:0007260)2.48232641
25Chronic hepatic failure (HP:0100626)2.43062512
26Renal cortical cysts (HP:0000803)2.42419903
27Volvulus (HP:0002580)2.38467918
28Failure to thrive in infancy (HP:0001531)2.37564316
29Amyotrophic lateral sclerosis (HP:0007354)2.29085322
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28379253
31Gonadal dysgenesis (HP:0000133)2.28346702
32Excessive salivation (HP:0003781)2.23741247
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.20538216
34Inability to walk (HP:0002540)2.18898243
35Lissencephaly (HP:0001339)2.17407579
36Abnormal biliary tract physiology (HP:0012439)2.15179647
37Bile duct proliferation (HP:0001408)2.15179647
38Narrow forehead (HP:0000341)2.12852667
39Postaxial foot polydactyly (HP:0001830)2.12696906
40Polyphagia (HP:0002591)2.12639531
41Hypothermia (HP:0002045)2.10417801
42Cerebellar dysplasia (HP:0007033)2.08117444
43Gaze-evoked nystagmus (HP:0000640)2.06339159
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.06333687
45Long clavicles (HP:0000890)2.06320575
46Postaxial hand polydactyly (HP:0001162)2.06297478
47Retinal dysplasia (HP:0007973)2.04652413
48Poor coordination (HP:0002370)2.04256899
49Cystic liver disease (HP:0006706)2.03438210
50Sclerocornea (HP:0000647)2.00783655
51Abnormal biliary tract morphology (HP:0012440)1.97558608
52Gonadotropin excess (HP:0000837)1.97355386
53Small hand (HP:0200055)1.97064103
54Tubulointerstitial nephritis (HP:0001970)1.96728814
55Degeneration of the lateral corticospinal tracts (HP:0002314)1.95263099
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95263099
57Attenuation of retinal blood vessels (HP:0007843)1.95009250
58Abolished electroretinogram (ERG) (HP:0000550)1.94923133
59Bifid tongue (HP:0010297)1.94914232
60Congenital hepatic fibrosis (HP:0002612)1.94763665
61Abnormality of chromosome stability (HP:0003220)1.94223535
62Occipital encephalocele (HP:0002085)1.90790880
63Specific learning disability (HP:0001328)1.87521231
64Short tibia (HP:0005736)1.86048177
65Astigmatism (HP:0000483)1.85586654
66Broad foot (HP:0001769)1.83430685
67Long nose (HP:0003189)1.81393604
68Calf muscle hypertrophy (HP:0008981)1.78841857
69Abnormal ciliary motility (HP:0012262)1.77564750
70Hypokalemic alkalosis (HP:0001949)1.77552104
71Atonic seizures (HP:0010819)1.74818314
72Anencephaly (HP:0002323)1.73614325
73Prominent nasal bridge (HP:0000426)1.73611760
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.71719652
75Ketoacidosis (HP:0001993)1.71625468
76Abnormal respiratory motile cilium physiology (HP:0012261)1.70652507
77Protruding tongue (HP:0010808)1.70543502
78Biliary tract neoplasm (HP:0100574)1.70500852
79Short 1st metacarpal (HP:0010034)1.70304981
80Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70304981
81Genetic anticipation (HP:0003743)1.70252424
82Abnormal respiratory epithelium morphology (HP:0012253)1.69928114
83Abnormal respiratory motile cilium morphology (HP:0005938)1.69928114
84Impaired vibration sensation in the lower limbs (HP:0002166)1.69714064
85Aplasia/hypoplasia of the uterus (HP:0008684)1.68722781
86Urinary urgency (HP:0000012)1.68656846
87Pachygyria (HP:0001302)1.68094118
88Hyperglycinemia (HP:0002154)1.68054189
89Tubular atrophy (HP:0000092)1.67860415
90Polyuria (HP:0000103)1.67838997
91Congenital stationary night blindness (HP:0007642)1.67793131
92Preaxial hand polydactyly (HP:0001177)1.67618542
93Renal hypoplasia (HP:0000089)1.67489174
94Focal motor seizures (HP:0011153)1.67337249
95Abnormal rod and cone electroretinograms (HP:0008323)1.66768148
96Decreased testicular size (HP:0008734)1.65704383
97Tubulointerstitial abnormality (HP:0001969)1.65591872
98Short foot (HP:0001773)1.65085083
99Aplasia/Hypoplasia of the lens (HP:0008063)1.64293621
100Papillary thyroid carcinoma (HP:0002895)1.64146588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.81088345
2FRK3.64082240
3CASK3.31960736
4MAP3K43.27973934
5PINK12.94315620
6BCR2.64899324
7STK38L2.61869776
8BRSK22.47891739
9MAPK132.37905397
10ERBB32.32596424
11MAP2K72.31186819
12WNK32.25496183
13NUAK12.23323151
14PRKD32.16110171
15GRK11.98172779
16MAP4K21.97323215
17OBSCN1.49621486
18PAK31.48317780
19STK391.47344395
20BRD41.46896635
21NEK91.46766069
22MAP3K61.35224507
23INSRR1.34867237
24BCKDK1.32098124
25SIK31.31860391
26MAP2K41.29526426
27WEE11.24362317
28TNIK1.20466633
29MARK11.20307421
30ZAK1.20288732
31ADRBK21.20254647
32OXSR11.18121278
33SRPK11.17350455
34BMPR1B1.13649422
35PNCK1.13245037
36CSNK1G11.11183439
37CSNK1G21.09619235
38PLK21.04549597
39DAPK21.02472663
40PRKCE1.01645023
41MKNK21.00380557
42EIF2AK30.99948404
43LATS10.99245598
44CAMKK20.90265542
45CSNK1G30.88357998
46AKT30.87874558
47CSNK1A1L0.86829935
48TSSK60.85365954
49ACVR1B0.81811429
50PKN10.80085551
51NLK0.78822794
52MKNK10.77691578
53DYRK1A0.72665911
54WNK40.72002533
55PHKG20.71903492
56PHKG10.71903492
57CDK190.62677318
58PLK30.60947866
59PLK40.56763144
60SGK20.56063388
61STK380.53871296
62PIK3CG0.53718563
63PRKCG0.51941383
64ATM0.51329706
65EPHA40.50472733
66YES10.48488295
67CCNB10.48148898
68DYRK30.47477959
69FGFR30.47442691
70STK30.45505576
71TEC0.45501780
72CSNK1D0.45392450
73VRK10.45279994
74PBK0.45237428
75GRK70.43183928
76PRKAA10.43180910
77FER0.42730943
78MINK10.42567760
79CAMK2A0.40830655
80RPS6KB10.40574496
81PRKACB0.40161969
82ERBB40.40035281
83FGFR10.39862074
84PLK10.39744463
85ROCK10.39177350
86MST40.38995230
87MAP3K70.38904880
88MAP2K60.38291252
89CAMK1G0.37486285
90PASK0.37378557
91PRKD20.35048870
92PRKACA0.34154743
93TGFBR10.33579397
94WNK10.33450441
95PRKDC0.33002509
96DYRK20.32523853
97PRKAA20.32389126
98RPS6KA40.32360607
99EGFR0.30077809
100PRKG10.28423578

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32066151
2Propanoate metabolism_Homo sapiens_hsa006403.27452348
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.67306212
4Non-homologous end-joining_Homo sapiens_hsa034502.66957448
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56782874
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53261044
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40092188
8Butanoate metabolism_Homo sapiens_hsa006502.31338915
9Protein export_Homo sapiens_hsa030602.17840676
10Circadian rhythm_Homo sapiens_hsa047102.15398120
11Phototransduction_Homo sapiens_hsa047442.01441386
12Taste transduction_Homo sapiens_hsa047421.98587767
13Nicotine addiction_Homo sapiens_hsa050331.98337289
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93630316
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81634687
16Caffeine metabolism_Homo sapiens_hsa002321.81437326
17Basal transcription factors_Homo sapiens_hsa030221.73547172
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69668034
19Fanconi anemia pathway_Homo sapiens_hsa034601.56953016
20Ether lipid metabolism_Homo sapiens_hsa005651.54813019
21RNA degradation_Homo sapiens_hsa030181.52135320
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.45015712
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43224401
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35673715
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33102250
26Regulation of autophagy_Homo sapiens_hsa041401.32204551
27Olfactory transduction_Homo sapiens_hsa047401.30395531
28Linoleic acid metabolism_Homo sapiens_hsa005911.30162786
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.27238789
30Tryptophan metabolism_Homo sapiens_hsa003801.19906513
31Retinol metabolism_Homo sapiens_hsa008301.17302360
32Steroid biosynthesis_Homo sapiens_hsa001001.16866037
33TGF-beta signaling pathway_Homo sapiens_hsa043501.16720971
34Hedgehog signaling pathway_Homo sapiens_hsa043401.14400657
35beta-Alanine metabolism_Homo sapiens_hsa004101.12242410
36Peroxisome_Homo sapiens_hsa041461.11655908
37Sphingolipid metabolism_Homo sapiens_hsa006001.07578578
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06479368
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05261204
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.05102519
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04859173
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04704713
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04444207
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03174548
45Homologous recombination_Homo sapiens_hsa034401.00677733
46Selenocompound metabolism_Homo sapiens_hsa004501.00674948
47Circadian entrainment_Homo sapiens_hsa047130.99859715
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99297504
49Morphine addiction_Homo sapiens_hsa050320.95858364
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95531342
51Oocyte meiosis_Homo sapiens_hsa041140.94487856
52Dorso-ventral axis formation_Homo sapiens_hsa043200.91621080
53GABAergic synapse_Homo sapiens_hsa047270.91512380
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90869249
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90541426
56Dopaminergic synapse_Homo sapiens_hsa047280.87515976
57Glutamatergic synapse_Homo sapiens_hsa047240.86763719
58Nitrogen metabolism_Homo sapiens_hsa009100.84406505
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83813889
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.83541517
61Serotonergic synapse_Homo sapiens_hsa047260.82635611
62Lysine degradation_Homo sapiens_hsa003100.82465379
63Chemical carcinogenesis_Homo sapiens_hsa052040.82307075
64Calcium signaling pathway_Homo sapiens_hsa040200.77675834
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77145372
66RNA polymerase_Homo sapiens_hsa030200.77020216
67Amphetamine addiction_Homo sapiens_hsa050310.72630522
68RNA transport_Homo sapiens_hsa030130.66855237
69Salivary secretion_Homo sapiens_hsa049700.65034465
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63725907
71Fatty acid degradation_Homo sapiens_hsa000710.62830445
72Insulin secretion_Homo sapiens_hsa049110.61169548
73Fatty acid metabolism_Homo sapiens_hsa012120.59907747
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59687782
75Sulfur metabolism_Homo sapiens_hsa009200.59368220
76ABC transporters_Homo sapiens_hsa020100.57972668
77Renin secretion_Homo sapiens_hsa049240.55219164
78Ovarian steroidogenesis_Homo sapiens_hsa049130.53243889
79Glucagon signaling pathway_Homo sapiens_hsa049220.51223141
80Pyruvate metabolism_Homo sapiens_hsa006200.51156311
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50601439
82Metabolic pathways_Homo sapiens_hsa011000.49484444
83Fatty acid elongation_Homo sapiens_hsa000620.47416211
84Purine metabolism_Homo sapiens_hsa002300.46633215
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46012499
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44742333
87Long-term depression_Homo sapiens_hsa047300.43338357
88Histidine metabolism_Homo sapiens_hsa003400.43031750
89Nucleotide excision repair_Homo sapiens_hsa034200.42704733
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42173355
91Wnt signaling pathway_Homo sapiens_hsa043100.41970348
92Starch and sucrose metabolism_Homo sapiens_hsa005000.40892012
93cAMP signaling pathway_Homo sapiens_hsa040240.40485764
94Mismatch repair_Homo sapiens_hsa034300.39907703
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38098889
96mRNA surveillance pathway_Homo sapiens_hsa030150.37667806
97Axon guidance_Homo sapiens_hsa043600.37267325
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34616432
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33442534
100Arachidonic acid metabolism_Homo sapiens_hsa005900.32258625

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