ZNF655

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.58607285
2regulation of B cell receptor signaling pathway (GO:0050855)5.20467122
3negative regulation of cell killing (GO:0031342)5.11535713
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.11535713
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11133371
6positive regulation of granulocyte differentiation (GO:0030854)4.93746287
7regulation of gamma-delta T cell differentiation (GO:0045586)4.85008538
8regulation of gamma-delta T cell activation (GO:0046643)4.83697738
9negative thymic T cell selection (GO:0045060)4.78318065
10negative T cell selection (GO:0043383)4.71685216
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45336345
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.37073158
13antigen processing and presentation of endogenous antigen (GO:0019883)4.19389694
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17664968
15response to interleukin-15 (GO:0070672)3.97357051
16positive T cell selection (GO:0043368)3.87424841
17B cell receptor signaling pathway (GO:0050853)3.79846580
18positive thymic T cell selection (GO:0045059)3.78478623
19cellular response to ethanol (GO:0071361)3.69602076
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69184953
21interferon-gamma production (GO:0032609)3.68812220
22mannose metabolic process (GO:0006013)3.63959575
23response to muramyl dipeptide (GO:0032495)3.63899519
24tolerance induction (GO:0002507)3.63587126
25activated T cell proliferation (GO:0050798)3.60326718
26embryonic process involved in female pregnancy (GO:0060136)3.59117988
27histone H3-K4 trimethylation (GO:0080182)3.56486036
28negative regulation of erythrocyte differentiation (GO:0045647)3.53544869
29cellular extravasation (GO:0045123)3.52103020
30T cell migration (GO:0072678)3.49171511
31T cell selection (GO:0045058)3.48345826
32regulation of histone H3-K27 methylation (GO:0061085)3.36721275
33negative regulation of T cell mediated immunity (GO:0002710)3.33046520
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.30328837
35regulation of granulocyte differentiation (GO:0030852)3.30188311
36detection of other organism (GO:0098543)3.26773577
37negative regulation of neurotransmitter secretion (GO:0046929)3.26684709
38cellular response to interleukin-15 (GO:0071350)3.25399244
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.24335631
40leukocyte aggregation (GO:0070486)3.23895964
41thymic T cell selection (GO:0045061)3.23635158
42positive regulation of B cell differentiation (GO:0045579)3.22469506
43regulation of B cell differentiation (GO:0045577)3.17123641
44phospholipid scrambling (GO:0017121)3.15750630
45mature B cell differentiation (GO:0002335)3.15278873
46regulation of regulatory T cell differentiation (GO:0045589)3.13965441
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10809761
48detection of bacterium (GO:0016045)3.06433768
49neutrophil activation involved in immune response (GO:0002283)3.01866923
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98777534
51regulation of T cell tolerance induction (GO:0002664)2.97480515
52histone H3-K9 modification (GO:0061647)2.96380868
53regulation of alpha-beta T cell proliferation (GO:0046640)2.96062114
54B cell homeostasis (GO:0001782)2.95943420
55mature B cell differentiation involved in immune response (GO:0002313)2.93553973
56histone H3-K36 demethylation (GO:0070544)2.93042960
57germinal center formation (GO:0002467)2.93001624
58Peyers patch development (GO:0048541)2.85917793
59mucosal-associated lymphoid tissue development (GO:0048537)2.85917793
60monoubiquitinated protein deubiquitination (GO:0035520)2.84722310
61T cell homeostasis (GO:0043029)2.82238435
62histone H3-K9 demethylation (GO:0033169)2.82003595
63regulation of necroptotic process (GO:0060544)2.81933548
64negative regulation of leukocyte mediated immunity (GO:0002704)2.80885623
65regulation of tolerance induction (GO:0002643)2.80808376
66antigen receptor-mediated signaling pathway (GO:0050851)2.80015942
67interleukin-6-mediated signaling pathway (GO:0070102)2.79752234
68dendritic cell chemotaxis (GO:0002407)2.79500674
69detection of external biotic stimulus (GO:0098581)2.71275036
70negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69929670
71negative regulation of T-helper cell differentiation (GO:0045623)2.69929670
72dendritic cell migration (GO:0036336)2.69445456
73lymphocyte homeostasis (GO:0002260)2.69385424
74negative regulation of interleukin-12 production (GO:0032695)2.69208937
75regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68309809
76positive regulation by organism of defense response of other organism involved in symbiotic interact2.68167396
77modulation by symbiont of host immune response (GO:0052553)2.68167396
78positive regulation by symbiont of host defense response (GO:0052509)2.68167396
79modulation by symbiont of host defense response (GO:0052031)2.68167396
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68167396
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68167396
82alpha-beta T cell differentiation (GO:0046632)2.68112992
83regulation of interferon-beta biosynthetic process (GO:0045357)2.66600515
84positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66571140
85natural killer cell differentiation (GO:0001779)2.65601873
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65569412
87positive regulation of tolerance induction (GO:0002645)2.65466259
88T cell receptor signaling pathway (GO:0050852)2.65435060
89positive regulation of interleukin-2 production (GO:0032743)2.63768212
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.63730874
91dosage compensation (GO:0007549)2.63722758
92macrophage activation involved in immune response (GO:0002281)2.62980170
93detection of molecule of bacterial origin (GO:0032490)2.62931873
94regulation of natural killer cell mediated immunity (GO:0002715)2.62194446
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62194446
96interkinetic nuclear migration (GO:0022027)2.59324038
97peptidyl-lysine trimethylation (GO:0018023)2.57066780
98histone H3-K9 methylation (GO:0051567)2.56126161
99neutrophil activation (GO:0042119)2.55283860
100alpha-beta T cell activation (GO:0046631)2.53957899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.82179534
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.89315273
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.89053858
4RUNX_20019798_ChIP-Seq_JUKART_Human3.26365715
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.20863075
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.06109901
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.03231166
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90866180
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85807065
10MYB_26560356_Chip-Seq_TH2_Human2.68523564
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67970456
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.57357548
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.55993520
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48577248
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42145904
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41536633
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38615363
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23753873
19MYB_26560356_Chip-Seq_TH1_Human2.23000002
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10840865
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09446796
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01267299
23GATA3_27048872_Chip-Seq_THYMUS_Human1.97966020
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.97414974
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94839088
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89972860
27MYC_22102868_ChIP-Seq_BL_Human1.86208345
28* SPI1_23127762_ChIP-Seq_K562_Human1.82467329
29VDR_24787735_ChIP-Seq_THP-1_Human1.73529829
30* SPI1_23547873_ChIP-Seq_NB4_Human1.73158462
31SCL_19346495_ChIP-Seq_HPC-7_Human1.70509098
32MAF_26560356_Chip-Seq_TH1_Human1.70462612
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67535524
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58945293
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57409431
36GATA1_22025678_ChIP-Seq_K562_Human1.56021739
37GATA3_26560356_Chip-Seq_TH2_Human1.53267911
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53252583
39UTX_26944678_Chip-Seq_JUKART_Human1.52392364
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50721110
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47749980
42VDR_24763502_ChIP-Seq_THP-1_Human1.43374442
43TP53_16413492_ChIP-PET_HCT116_Human1.41088919
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38692614
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38171810
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.37734617
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.37329332
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37253647
49TCF7_22412390_ChIP-Seq_EML_Mouse1.35757949
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.32480663
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.31902873
52PU_27001747_Chip-Seq_BMDM_Mouse1.30287093
53GATA1_19941826_ChIP-Seq_K562_Human1.25008556
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24371014
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.21059260
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20741123
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.18317744
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13280500
59GATA2_19941826_ChIP-Seq_K562_Human1.11624466
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11141594
61CIITA_25753668_ChIP-Seq_RAJI_Human1.10663012
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.10514163
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07205076
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06686057
65MAF_26560356_Chip-Seq_TH2_Human1.06622799
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01472708
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00920713
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00745846
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99012680
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97211641
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97200550
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96762877
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95383812
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92241318
75GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90559476
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90396050
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.90396021
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89814588
79BRD4_25478319_ChIP-Seq_HGPS_Human0.87818869
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.86809595
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86391077
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84150083
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.83782182
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83592716
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83564691
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83348230
87SMRT_27268052_Chip-Seq_Bcells_Human0.82450259
88VDR_21846776_ChIP-Seq_THP-1_Human0.82221560
89TCF4_18268006_ChIP-ChIP_LS174T_Human0.81846482
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.81030744
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80829910
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.80705727
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79863086
94KDM2B_26808549_Chip-Seq_DND41_Human0.78189162
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78100303
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77298500
97STAT3_23295773_ChIP-Seq_U87_Human0.77077529
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77021212
99IGF1R_20145208_ChIP-Seq_DFB_Human0.75892679
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75803200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.78368088
2MP0001835_abnormal_antigen_presentation3.53515982
3MP0003436_decreased_susceptibility_to3.39799828
4MP0003724_increased_susceptibility_to3.14846177
5MP0001800_abnormal_humoral_immune3.12463135
6MP0003300_gastrointestinal_ulcer3.09553863
7MP0002396_abnormal_hematopoietic_system2.99456672
8MP0002009_preneoplasia2.94978090
9MP0005671_abnormal_response_to2.83592646
10MP0005000_abnormal_immune_tolerance2.70553864
11MP0000685_abnormal_immune_system2.61273085
12MP0002723_abnormal_immune_serum2.45289986
13MP0001790_abnormal_immune_system2.41316405
14MP0005387_immune_system_phenotype2.41316405
15MP0002452_abnormal_antigen_presenting2.37463829
16MP0002419_abnormal_innate_immunity2.34617533
17MP0002420_abnormal_adaptive_immunity2.33968634
18MP0001819_abnormal_immune_cell2.31574804
19MP0008961_abnormal_basal_metabolism2.30213069
20MP0008057_abnormal_DNA_replication2.27235221
21MP0003828_pulmonary_edema2.15351076
22MP0005025_abnormal_response_to2.13467325
23MP0002398_abnormal_bone_marrow2.12755293
24MP0003656_abnormal_erythrocyte_physiolo2.06868639
25MP0002405_respiratory_system_inflammati2.02968661
26MP0000703_abnormal_thymus_morphology2.00527313
27MP0003303_peritoneal_inflammation1.96958314
28MP0000716_abnormal_immune_system1.93724852
29MP0000569_abnormal_digit_pigmentation1.89477877
30MP0003172_abnormal_lysosome_physiology1.88575664
31MP0010155_abnormal_intestine_physiology1.84325011
32MP0004947_skin_inflammation1.83781673
33MP0009785_altered_susceptibility_to1.80948813
34MP0000689_abnormal_spleen_morphology1.78898864
35MP0002722_abnormal_immune_system1.78009903
36MP0003866_abnormal_defecation1.77518295
37MP0004808_abnormal_hematopoietic_stem1.71675356
38MP0000465_gastrointestinal_hemorrhage1.69130432
39MP0006082_CNS_inflammation1.66713067
40MP0002166_altered_tumor_susceptibility1.61216074
41MP0005464_abnormal_platelet_physiology1.53924324
42MP0001533_abnormal_skeleton_physiology1.52612753
43MP0001845_abnormal_inflammatory_respons1.50394713
44MP0002429_abnormal_blood_cell1.49696752
45MP0001851_eye_inflammation1.46791969
46MP0003091_abnormal_cell_migration1.42101544
47MP0003045_fibrosis1.40996268
48MP0004883_abnormal_blood_vessel1.37227051
49MP0006054_spinal_hemorrhage1.35559068
50MP0002998_abnormal_bone_remodeling1.34409570
51MP0002933_joint_inflammation1.34124387
52MP0002148_abnormal_hypersensitivity_rea1.34091918
53MP0009333_abnormal_splenocyte_physiolog1.33612731
54MP0009278_abnormal_bone_marrow1.23738460
55MP0003690_abnormal_glial_cell1.23211453
56MP0005397_hematopoietic_system_phenotyp1.19642671
57MP0001545_abnormal_hematopoietic_system1.19642671
58MP0001853_heart_inflammation1.19028464
59MP0003252_abnormal_bile_duct1.18436915
60MP0004381_abnormal_hair_follicle1.08000574
61MP0005310_abnormal_salivary_gland1.04430857
62MP0005164_abnormal_response_to1.04177085
63MP0009115_abnormal_fat_cell1.03388925
64MP0005451_abnormal_body_composition1.03363061
65MP0003191_abnormal_cellular_cholesterol1.01231360
66MP0008260_abnormal_autophagy1.00711714
67MP0004130_abnormal_muscle_cell0.98754121
68MP0010352_gastrointestinal_tract_polyps0.96651979
69MP0008469_abnormal_protein_level0.95639823
70MP0002006_tumorigenesis0.94126890
71MP0001873_stomach_inflammation0.92135114
72MP0009764_decreased_sensitivity_to0.85734292
73MP0009763_increased_sensitivity_to0.81589069
74MP0003183_abnormal_peptide_metabolism0.81444006
75MP0005075_abnormal_melanosome_morpholog0.79581776
76MP0000604_amyloidosis0.77335334
77MP0000015_abnormal_ear_pigmentation0.77117790
78MP0001986_abnormal_taste_sensitivity0.75897122
79MP0001958_emphysema0.75380563
80MP0000858_altered_metastatic_potential0.75286347
81MP0000249_abnormal_blood_vessel0.72528599
82MP0005360_urolithiasis0.72000459
83MP0003795_abnormal_bone_structure0.71606701
84MP0002133_abnormal_respiratory_system0.69916740
85MP0005388_respiratory_system_phenotype0.69916740
86MP0003221_abnormal_cardiomyocyte_apopto0.69385446
87MP0002019_abnormal_tumor_incidence0.68400502
88MP0001915_intracranial_hemorrhage0.66268305
89MP0003868_abnormal_feces_composition0.66061967
90MP0010307_abnormal_tumor_latency0.65352796
91MP0000371_diluted_coat_color0.64836572
92MP0005621_abnormal_cell_physiology0.62201193
93MP0002136_abnormal_kidney_physiology0.62051445
94MP0009765_abnormal_xenobiotic_induced0.59755652
95MP0002971_abnormal_brown_adipose0.57656014
96MP0003448_altered_tumor_morphology0.56716615
97MP0002928_abnormal_bile_duct0.56181126
98MP0008995_early_reproductive_senescence0.55755566
99MP0002168_other_aberrant_phenotype0.55297919
100MP0002132_abnormal_respiratory_system0.55077514

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.15299411
2T lymphocytopenia (HP:0005403)4.60511616
3Abnormality of T cell number (HP:0011839)4.21029713
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.97169983
5Recurrent bacterial skin infections (HP:0005406)3.66639205
6Myositis (HP:0100614)3.61932813
7Spontaneous hematomas (HP:0007420)3.55658814
8Recurrent fungal infections (HP:0002841)3.53250287
9Recurrent abscess formation (HP:0002722)3.46952550
10Panhypogammaglobulinemia (HP:0003139)3.27405904
11Increased IgE level (HP:0003212)3.26030654
12Recurrent viral infections (HP:0004429)3.25853626
13Abnormality of the fingertips (HP:0001211)3.21241972
14Pustule (HP:0200039)3.19221439
15Mediastinal lymphadenopathy (HP:0100721)3.16341935
16Chronic mucocutaneous candidiasis (HP:0002728)3.14482725
17Recurrent cutaneous fungal infections (HP:0011370)3.14482725
18Elevated erythrocyte sedimentation rate (HP:0003565)3.13108812
19Colitis (HP:0002583)3.11481107
20Abnormality of T cells (HP:0002843)3.09757997
21Gastrointestinal infarctions (HP:0005244)3.07504451
22Retrobulbar optic neuritis (HP:0100654)3.01146628
23Optic neuritis (HP:0100653)3.01146628
24Gingivitis (HP:0000230)3.00097201
25Pulmonary infiltrates (HP:0002113)2.99855273
26Severe combined immunodeficiency (HP:0004430)2.87395606
27Recurrent gram-negative bacterial infections (HP:0005420)2.86116921
28Inflammation of the large intestine (HP:0002037)2.85691298
29Orchitis (HP:0100796)2.81258054
30Granulocytopenia (HP:0001913)2.79784925
31Leukocytosis (HP:0001974)2.71861672
32Recurrent skin infections (HP:0001581)2.71764762
33Meningitis (HP:0001287)2.71602502
34Recurrent bronchitis (HP:0002837)2.70847706
35Epistaxis (HP:0000421)2.70683980
36Stomatitis (HP:0010280)2.70646128
37Vasculitis (HP:0002633)2.67960106
38Papilledema (HP:0001085)2.66421452
39Autoimmune hemolytic anemia (HP:0001890)2.64009438
40Gastrointestinal inflammation (HP:0004386)2.58332824
41IgG deficiency (HP:0004315)2.48929516
42Abnormality of eosinophils (HP:0001879)2.45873924
43Abnormality of T cell physiology (HP:0011840)2.44776639
44Eosinophilia (HP:0001880)2.43829236
45Abnormality of macrophages (HP:0004311)2.42691055
46Abnormality of the common coagulation pathway (HP:0010990)2.42508488
47Chest pain (HP:0100749)2.41865538
48Gingival bleeding (HP:0000225)2.40027763
49Prolonged bleeding time (HP:0003010)2.39671253
50Chronic diarrhea (HP:0002028)2.39089306
51Encephalitis (HP:0002383)2.36803367
52Fatigue (HP:0012378)2.35142994
53Keratoconjunctivitis sicca (HP:0001097)2.33962797
54Combined immunodeficiency (HP:0005387)2.31802360
55Abnormality of B cell number (HP:0010975)2.30478847
56Hematochezia (HP:0002573)2.30348972
57Hemoptysis (HP:0002105)2.30224131
58IgM deficiency (HP:0002850)2.29896625
59Viral hepatitis (HP:0006562)2.29879040
60Lymphopenia (HP:0001888)2.22117619
61Agammaglobulinemia (HP:0004432)2.20188017
62Spinal cord lesions (HP:0100561)2.18562488
63Syringomyelia (HP:0003396)2.18562488
64Hypoplasia of the thymus (HP:0000778)2.17940730
65Subacute progressive viral hepatitis (HP:0006572)2.17285498
66Keratoconjunctivitis (HP:0001096)2.16262084
67B lymphocytopenia (HP:0010976)2.12364434
68Obstructive lung disease (HP:0006536)2.11444316
69Chronic obstructive pulmonary disease (HP:0006510)2.11444316
70Persistence of primary teeth (HP:0006335)2.11264197
71Pulmonary embolism (HP:0002204)2.09541425
72Thyroiditis (HP:0100646)2.09245052
73Cellulitis (HP:0100658)2.07355933
74Menorrhagia (HP:0000132)2.06049264
75Interstitial pulmonary disease (HP:0006530)2.05580859
76IgA deficiency (HP:0002720)2.03652960
77Basal cell carcinoma (HP:0002671)2.02030730
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.01689239
79Dislocated radial head (HP:0003083)2.01380292
80Widely spaced teeth (HP:0000687)2.00254068
81Papillary thyroid carcinoma (HP:0002895)2.00253266
82Heterotopia (HP:0002282)1.99771749
83Dilatation of the ascending aorta (HP:0005111)1.96350467
84Stomach cancer (HP:0012126)1.94076188
85Neoplasm of the tracheobronchial system (HP:0100552)1.93739638
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91387982
87Acrocyanosis (HP:0001063)1.91306348
88Acute hepatic failure (HP:0006554)1.87316146
89Papilloma (HP:0012740)1.86747538
90Verrucae (HP:0200043)1.86747538
91Vertebral arch anomaly (HP:0008438)1.86550573
92Osteomyelitis (HP:0002754)1.83452263
93Conjunctival telangiectasia (HP:0000524)1.83410320
94Arterial thrombosis (HP:0004420)1.83061432
95Pulmonary fibrosis (HP:0002206)1.82852343
96Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81731851
97Aortic aneurysm (HP:0004942)1.81016084
98Acute myeloid leukemia (HP:0004808)1.80372580
99Slow saccadic eye movements (HP:0000514)1.80323201
100Glomerulopathy (HP:0100820)1.75364634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.03066667
2BRD42.98946832
3TAOK32.91390873
4RIPK42.69922467
5MAP4K12.68269584
6NLK2.43448369
7MAP3K142.29191849
8TYK22.27915854
9PRPF4B2.27446894
10BLK2.09770963
11EPHA32.08454449
12JAK11.97842618
13ZAP701.88051127
14FGFR31.87096242
15CDK121.84441007
16BCKDK1.70991714
17FGFR41.67607433
18BTK1.66495711
19BMPR21.58198065
20JAK31.52283254
21SIK31.49447606
22FES1.47201066
23IKBKE1.46667989
24SYK1.44603842
25CSK1.43472910
26ITK1.43106966
27TEC1.41756698
28GRK61.36178289
29CAMKK21.35699131
30HCK1.33667551
31MARK31.30035450
32MAP3K71.29044652
33EIF2AK31.26754343
34AKT31.26029936
35JAK21.25893683
36MAP3K131.19364281
37SIK21.14529115
38LCK1.14033405
39IRAK41.13598262
40MAP3K101.12363103
41MAPK71.10949195
42MAP2K31.07823253
43EPHB11.07790173
44FRK1.02784711
45KSR21.01318523
46LYN1.01120836
47CDK61.00599668
48MAP3K20.98837046
49ACVR1B0.97827634
50SGK20.95620153
51CDC42BPA0.95051165
52STK100.93512792
53PASK0.91092671
54MAPK110.90025091
55TBK10.89353270
56FGR0.87562140
57YES10.87535191
58NEK90.85338647
59MARK20.84415639
60TRPM70.84050073
61KIT0.80375328
62PIK3CG0.80068898
63IRAK10.79235931
64CLK10.78341842
65ERN10.78000204
66RET0.77880448
67PDGFRB0.75116715
68IKBKB0.74384268
69MAP3K60.73538133
70ERBB30.72947407
71SGK30.71995242
72TGFBR20.70465869
73PIM10.69055666
74CAMKK10.67743369
75WNK10.66206046
76KSR10.64837167
77MELK0.64795525
78CDK40.62546058
79BRSK20.60005937
80HIPK20.57358815
81RAF10.56826530
82PKN20.54545986
83SGK4940.54132072
84SGK2230.54132072
85MAP3K10.54015967
86PDK10.54003874
87MAPK120.52989165
88TNK20.48971555
89CSF1R0.48310683
90ICK0.47564962
91ABL10.45759170
92PRKCQ0.45505856
93LATS10.45002141
94MKNK20.44196376
95CAMK40.42941045
96GRK70.40733997
97PDGFRA0.40078658
98SGK10.38740622
99CHUK0.37912792
100STK380.37540408

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.28460245
2Leishmaniasis_Homo sapiens_hsa051402.22237676
3Osteoclast differentiation_Homo sapiens_hsa043802.15615325
4Graft-versus-host disease_Homo sapiens_hsa053322.14717705
5B cell receptor signaling pathway_Homo sapiens_hsa046622.12848685
6T cell receptor signaling pathway_Homo sapiens_hsa046602.10959080
7Allograft rejection_Homo sapiens_hsa053301.99484958
8Autoimmune thyroid disease_Homo sapiens_hsa053201.94461373
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90992632
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.89875290
11Staphylococcus aureus infection_Homo sapiens_hsa051501.84499456
12Acute myeloid leukemia_Homo sapiens_hsa052211.81913422
13Measles_Homo sapiens_hsa051621.74881126
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73473544
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72550835
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.69874023
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69627639
18Type I diabetes mellitus_Homo sapiens_hsa049401.54677402
19Viral myocarditis_Homo sapiens_hsa054161.53146670
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48540999
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.48178726
22Toxoplasmosis_Homo sapiens_hsa051451.47459269
23Herpes simplex infection_Homo sapiens_hsa051681.39308068
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38678598
25Tuberculosis_Homo sapiens_hsa051521.38203993
26TNF signaling pathway_Homo sapiens_hsa046681.37962912
27Influenza A_Homo sapiens_hsa051641.35174064
28Hepatitis B_Homo sapiens_hsa051611.33470219
29Non-small cell lung cancer_Homo sapiens_hsa052231.33442196
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32606763
31Pancreatic cancer_Homo sapiens_hsa052121.30671682
32Hematopoietic cell lineage_Homo sapiens_hsa046401.30589149
33Colorectal cancer_Homo sapiens_hsa052101.28964901
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27346951
35Asthma_Homo sapiens_hsa053101.25611744
36Chemokine signaling pathway_Homo sapiens_hsa040621.24753775
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23508267
38Chronic myeloid leukemia_Homo sapiens_hsa052201.22024464
39Other glycan degradation_Homo sapiens_hsa005111.16089146
40Prolactin signaling pathway_Homo sapiens_hsa049171.13473848
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11655266
42Platelet activation_Homo sapiens_hsa046111.10995664
43Inositol phosphate metabolism_Homo sapiens_hsa005621.09780667
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08357926
45FoxO signaling pathway_Homo sapiens_hsa040681.06758382
46Antigen processing and presentation_Homo sapiens_hsa046121.06705423
47Malaria_Homo sapiens_hsa051441.04509442
48Choline metabolism in cancer_Homo sapiens_hsa052310.98160537
49Pertussis_Homo sapiens_hsa051330.95636985
50mTOR signaling pathway_Homo sapiens_hsa041500.94930663
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.94313384
52Legionellosis_Homo sapiens_hsa051340.94001258
53Hepatitis C_Homo sapiens_hsa051600.91130487
54Renal cell carcinoma_Homo sapiens_hsa052110.89659076
55Dorso-ventral axis formation_Homo sapiens_hsa043200.89388608
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88703128
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.87614845
58Apoptosis_Homo sapiens_hsa042100.87031827
59Circadian rhythm_Homo sapiens_hsa047100.83986311
60Endometrial cancer_Homo sapiens_hsa052130.82785330
61Viral carcinogenesis_Homo sapiens_hsa052030.81785804
62VEGF signaling pathway_Homo sapiens_hsa043700.78432152
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.75742032
64Prostate cancer_Homo sapiens_hsa052150.73114341
65ErbB signaling pathway_Homo sapiens_hsa040120.72893579
66Type II diabetes mellitus_Homo sapiens_hsa049300.72755056
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71629593
68Insulin resistance_Homo sapiens_hsa049310.71056052
69GnRH signaling pathway_Homo sapiens_hsa049120.68673508
70HTLV-I infection_Homo sapiens_hsa051660.68614351
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68540234
72MicroRNAs in cancer_Homo sapiens_hsa052060.67162440
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.63607794
74Shigellosis_Homo sapiens_hsa051310.63330584
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60519390
76Small cell lung cancer_Homo sapiens_hsa052220.59708497
77Epstein-Barr virus infection_Homo sapiens_hsa051690.59619074
78Adherens junction_Homo sapiens_hsa045200.58636855
79Thyroid cancer_Homo sapiens_hsa052160.58161525
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.57485018
81Glioma_Homo sapiens_hsa052140.57313421
82African trypanosomiasis_Homo sapiens_hsa051430.56650254
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53128358
84MAPK signaling pathway_Homo sapiens_hsa040100.52035025
85Long-term potentiation_Homo sapiens_hsa047200.51110639
86Phagosome_Homo sapiens_hsa041450.51031336
87ABC transporters_Homo sapiens_hsa020100.50190709
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49508549
89Rheumatoid arthritis_Homo sapiens_hsa053230.48329048
90Amoebiasis_Homo sapiens_hsa051460.47578446
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47230566
92HIF-1 signaling pathway_Homo sapiens_hsa040660.45997134
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45773744
94Lysine degradation_Homo sapiens_hsa003100.44548758
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44383639
96Endocytosis_Homo sapiens_hsa041440.42295478
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42221087
98Proteoglycans in cancer_Homo sapiens_hsa052050.42104091
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41072867
100Complement and coagulation cascades_Homo sapiens_hsa046100.40784506

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »