ZNF652

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translation, ncRNA-mediated (GO:0045974)4.20837901
2negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.20837901
3negative regulation of translation, ncRNA-mediated (GO:0040033)4.20837901
4protein K11-linked deubiquitination (GO:0035871)3.83973132
5establishment of protein localization to Golgi (GO:0072600)3.82946730
6early endosome to late endosome transport (GO:0045022)3.74395408
7phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.48968232
8protein targeting to Golgi (GO:0000042)3.47245974
9retrograde transport, vesicle recycling within Golgi (GO:0000301)3.38673915
10interkinetic nuclear migration (GO:0022027)3.26016188
11protein targeting to vacuole (GO:0006623)3.22747318
12protein targeting to lysosome (GO:0006622)3.22747318
13establishment of protein localization to vacuole (GO:0072666)3.22747318
14negative regulation of systemic arterial blood pressure (GO:0003085)3.20702956
15regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.17338780
16positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.17338780
17startle response (GO:0001964)3.13544610
18Golgi to endosome transport (GO:0006895)3.10462149
19prostate gland growth (GO:0060736)3.08034346
20reflex (GO:0060004)2.95238537
21peptidyl-threonine dephosphorylation (GO:0035970)2.94556094
22neural tube formation (GO:0001841)2.93410219
23histone H3-K4 trimethylation (GO:0080182)2.84441348
24sulfation (GO:0051923)2.84096646
25regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.83966784
26positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.83966784
27genitalia morphogenesis (GO:0035112)2.83136386
28dentate gyrus development (GO:0021542)2.82041961
29cellular response to ethanol (GO:0071361)2.81695382
30cytoplasmic mRNA processing body assembly (GO:0033962)2.80087839
31kidney morphogenesis (GO:0060993)2.78951621
32protein K48-linked deubiquitination (GO:0071108)2.76883130
33presynaptic membrane assembly (GO:0097105)2.75689012
34cerebellar Purkinje cell differentiation (GO:0021702)2.75485250
35protein localization to Golgi apparatus (GO:0034067)2.75177610
36behavioral response to nicotine (GO:0035095)2.74638164
37adaptation of signaling pathway (GO:0023058)2.65581690
38regulation of acrosome reaction (GO:0060046)2.64233518
39L-fucose catabolic process (GO:0042355)2.60705076
40fucose catabolic process (GO:0019317)2.60705076
41L-fucose metabolic process (GO:0042354)2.60705076
42negative regulation of hormone biosynthetic process (GO:0032353)2.59053922
43presynaptic membrane organization (GO:0097090)2.57642772
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55392607
45regulation of establishment or maintenance of cell polarity (GO:0032878)2.53027947
46multicellular organism reproduction (GO:0032504)2.51519469
47macroautophagy (GO:0016236)2.49584556
48regulation of establishment of cell polarity (GO:2000114)2.49103502
49activated T cell proliferation (GO:0050798)2.48530221
50microtubule anchoring (GO:0034453)2.44205372
51auditory behavior (GO:0031223)2.43247749
52positive regulation of glycolytic process (GO:0045821)2.42676235
53pyrimidine nucleobase catabolic process (GO:0006208)2.41082249
54monoubiquitinated protein deubiquitination (GO:0035520)2.40550213
55negative regulation of Ras GTPase activity (GO:0034261)2.39848710
56intestinal epithelial cell development (GO:0060576)2.38874720
57DNA methylation involved in gamete generation (GO:0043046)2.36241797
58positive regulation of mRNA catabolic process (GO:0061014)2.36010716
59piRNA metabolic process (GO:0034587)2.35607854
60spinal cord motor neuron differentiation (GO:0021522)2.35384442
61peptidyl-lysine trimethylation (GO:0018023)2.34882014
62keratinocyte development (GO:0003334)2.31646033
63intra-Golgi vesicle-mediated transport (GO:0006891)2.31582629
64otic vesicle formation (GO:0030916)2.30335951
65regulation of female receptivity (GO:0045924)2.28458595
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.27547291
67oocyte development (GO:0048599)2.25883505
68regulation of calcium ion-dependent exocytosis (GO:0017158)2.24885829
69nucleus localization (GO:0051647)2.24862162
70negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.24768775
71protein polyglutamylation (GO:0018095)2.24660294
72prenylation (GO:0097354)2.24401399
73protein prenylation (GO:0018342)2.24401399
74regulation of protein polyubiquitination (GO:1902914)2.22454480
75regulation of meiosis I (GO:0060631)2.22386026
76cell proliferation in forebrain (GO:0021846)2.22277553
77histone H3-K9 demethylation (GO:0033169)2.21928211
78regulation of type B pancreatic cell apoptotic process (GO:2000674)2.21647706
79regulation of memory T cell differentiation (GO:0043380)2.21469063
80neuronal action potential (GO:0019228)2.21433735
81indolalkylamine metabolic process (GO:0006586)2.21303134
82protein localization to lysosome (GO:0061462)2.18749990
83protein localization to vacuole (GO:0072665)2.18749990
84endocrine pancreas development (GO:0031018)2.18332759
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.18190904
86retina layer formation (GO:0010842)2.17930051
87regulation of hexokinase activity (GO:1903299)2.17237661
88regulation of glucokinase activity (GO:0033131)2.17237661
89labyrinthine layer development (GO:0060711)2.17072452
90negative regulation of protein oligomerization (GO:0032460)2.16969114
91interleukin-6-mediated signaling pathway (GO:0070102)2.15968363
92RNA destabilization (GO:0050779)2.15294620
93vacuolar transport (GO:0007034)2.15251131
94lysosomal transport (GO:0007041)2.14808666
95limb development (GO:0060173)2.14788654
96appendage development (GO:0048736)2.14788654
97histone H3-K9 methylation (GO:0051567)2.14776476
98regulation of collateral sprouting (GO:0048670)2.14663244
99endosome to lysosome transport (GO:0008333)2.14499412
100positive regulation of meiosis (GO:0045836)2.14477490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31277626
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17980870
3GBX2_23144817_ChIP-Seq_PC3_Human2.98802756
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78302430
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.77928728
6EZH2_22144423_ChIP-Seq_EOC_Human2.74066282
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40247425
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36363346
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22842283
10VDR_22108803_ChIP-Seq_LS180_Human2.19740103
11ZNF274_21170338_ChIP-Seq_K562_Hela2.18057858
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15589582
13IGF1R_20145208_ChIP-Seq_DFB_Human2.07879387
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.04539675
15ER_23166858_ChIP-Seq_MCF-7_Human2.03093404
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00479302
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.97278953
18* TAF15_26573619_Chip-Seq_HEK293_Human1.94865570
19FUS_26573619_Chip-Seq_HEK293_Human1.94822901
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94636497
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86626400
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86326268
23AHR_22903824_ChIP-Seq_MCF-7_Human1.80498620
24SMAD4_21799915_ChIP-Seq_A2780_Human1.79624766
25P300_19829295_ChIP-Seq_ESCs_Human1.78437367
26AR_21572438_ChIP-Seq_LNCaP_Human1.78262685
27EWS_26573619_Chip-Seq_HEK293_Human1.75673311
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.73700029
29* STAT3_23295773_ChIP-Seq_U87_Human1.71668337
30BCAT_22108803_ChIP-Seq_LS180_Human1.67020294
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66489586
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66443317
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64619103
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.64551198
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61394386
36TCF4_23295773_ChIP-Seq_U87_Human1.59965523
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54410789
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53899718
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53899718
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53425606
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50541121
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50272110
43AR_25329375_ChIP-Seq_VCAP_Human1.43008850
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42630915
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40521899
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40126682
47* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39902558
48* CBP_20019798_ChIP-Seq_JUKART_Human1.39902558
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38935485
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37833998
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.37070280
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34531587
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32995515
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.30190847
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.29763721
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28077998
57RUNX2_22187159_ChIP-Seq_PCA_Human1.28046195
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27008808
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.26997866
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26665747
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25889070
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25595420
63TP53_16413492_ChIP-PET_HCT116_Human1.24276407
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.23444403
65TCF4_22108803_ChIP-Seq_LS180_Human1.16903959
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.16585990
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14741480
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13931995
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13842574
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13372391
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11539940
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11379745
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10027984
74REST_21632747_ChIP-Seq_MESCs_Mouse1.09892534
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09398424
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07293934
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.06945251
78RNF2_27304074_Chip-Seq_NSC_Mouse1.06608358
79CDX2_22108803_ChIP-Seq_LS180_Human1.06523531
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.06408176
81* SMAD4_21741376_ChIP-Seq_EPCs_Human1.05975195
82P53_22387025_ChIP-Seq_ESCs_Mouse1.05730952
83KDM2B_26808549_Chip-Seq_REH_Human1.04349759
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.04203967
85DROSHA_22980978_ChIP-Seq_HELA_Human1.02498566
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01937240
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01273322
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01000873
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00603431
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.00363759
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00278071
92RXR_22108803_ChIP-Seq_LS180_Human0.99461469
93IRF1_19129219_ChIP-ChIP_H3396_Human0.97998308
94CMYC_18555785_Chip-Seq_ESCs_Mouse0.97447196
95RUNX_20019798_ChIP-Seq_JUKART_Human0.97429397
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96058622
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95392573
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.94229330
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92676888
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92492323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.80987569
2MP0003787_abnormal_imprinting4.12011069
3MP0008877_abnormal_DNA_methylation3.57709873
4MP0003195_calcinosis2.83431794
5MP0000427_abnormal_hair_cycle2.69240959
6MP0005075_abnormal_melanosome_morpholog2.12157923
7MP0002009_preneoplasia2.03026551
8MP0005174_abnormal_tail_pigmentation2.02287537
9MP0001984_abnormal_olfaction2.01979703
10MP0004381_abnormal_hair_follicle1.93069885
11MP0003121_genomic_imprinting1.92900667
12MP0003724_increased_susceptibility_to1.89810481
13MP0000383_abnormal_hair_follicle1.88564161
14MP0006292_abnormal_olfactory_placode1.85459258
15MP0003183_abnormal_peptide_metabolism1.85408386
16MP0008057_abnormal_DNA_replication1.80546066
17MP0005646_abnormal_pituitary_gland1.78295268
18MP0002138_abnormal_hepatobiliary_system1.74740442
19MP0004885_abnormal_endolymph1.69769396
20MP0001485_abnormal_pinna_reflex1.69635969
21MP0003122_maternal_imprinting1.67128005
22MP0005551_abnormal_eye_electrophysiolog1.66214481
23MP0000631_abnormal_neuroendocrine_gland1.61736481
24MP0003890_abnormal_embryonic-extraembry1.59901868
25MP0002102_abnormal_ear_morphology1.55955342
26MP0010678_abnormal_skin_adnexa1.53479915
27MP0001486_abnormal_startle_reflex1.49290319
28MP0002928_abnormal_bile_duct1.48313486
29MP0000372_irregular_coat_pigmentation1.47733636
30MP0004130_abnormal_muscle_cell1.47385200
31MP0003136_yellow_coat_color1.44007370
32MP0000015_abnormal_ear_pigmentation1.41581679
33MP0003646_muscle_fatigue1.34942166
34MP0004134_abnormal_chest_morphology1.29876526
35MP0002909_abnormal_adrenal_gland1.27639983
36MP0002277_abnormal_respiratory_mucosa1.24392831
37MP0002735_abnormal_chemical_nociception1.23530812
38MP0002272_abnormal_nervous_system1.19965144
39MP0005253_abnormal_eye_physiology1.17180577
40MP0003880_abnormal_central_pattern1.15840544
41MP0001986_abnormal_taste_sensitivity1.15356206
42MP0009780_abnormal_chondrocyte_physiolo1.14981162
43MP0004043_abnormal_pH_regulation1.13076574
44MP0004142_abnormal_muscle_tone1.10960544
45MP0001968_abnormal_touch/_nociception1.09506437
46MP0000371_diluted_coat_color1.09435471
47MP0002160_abnormal_reproductive_system1.07439456
48MP0003252_abnormal_bile_duct1.07039956
49MP0005386_behavior/neurological_phenoty1.06890410
50MP0004924_abnormal_behavior1.06890410
51MP0002638_abnormal_pupillary_reflex1.05408861
52MP0001324_abnormal_eye_pigmentation1.03472403
53MP0000470_abnormal_stomach_morphology1.03241927
54MP0002876_abnormal_thyroid_physiology1.03038969
55MP0003011_delayed_dark_adaptation1.02088834
56MP0009745_abnormal_behavioral_response1.01755288
57MP0005083_abnormal_biliary_tract1.01504825
58MP0002653_abnormal_ependyma_morphology1.01345225
59MP0005220_abnormal_exocrine_pancreas0.98393817
60MP0008872_abnormal_physiological_respon0.97879744
61MP0005248_abnormal_Harderian_gland0.96893483
62MP0002693_abnormal_pancreas_physiology0.94307470
63MP0000778_abnormal_nervous_system0.94286669
64MP0002166_altered_tumor_susceptibility0.93888514
65MP0005645_abnormal_hypothalamus_physiol0.92633454
66MP0002557_abnormal_social/conspecific_i0.91783687
67MP0005389_reproductive_system_phenotype0.90517268
68MP0005310_abnormal_salivary_gland0.88768204
69MP0001440_abnormal_grooming_behavior0.87887556
70MP0002095_abnormal_skin_pigmentation0.87851262
71MP0003635_abnormal_synaptic_transmissio0.85256005
72MP0002067_abnormal_sensory_capabilities0.84339087
73MP0001919_abnormal_reproductive_system0.82640445
74MP0001944_abnormal_pancreas_morphology0.82551810
75MP0009046_muscle_twitch0.80458263
76MP0004264_abnormal_extraembryonic_tissu0.79750077
77MP0002734_abnormal_mechanical_nocicepti0.78852207
78MP0002751_abnormal_autonomic_nervous0.78753795
79MP0002064_seizures0.77598875
80MP0006276_abnormal_autonomic_nervous0.77052708
81MP0003633_abnormal_nervous_system0.76650704
82MP0002282_abnormal_trachea_morphology0.75507335
83MP0002572_abnormal_emotion/affect_behav0.75037767
84MP0000465_gastrointestinal_hemorrhage0.74436267
85MP0001929_abnormal_gametogenesis0.73788526
86MP0001664_abnormal_digestion0.73220073
87MP0001188_hyperpigmentation0.72889434
88MP0002063_abnormal_learning/memory/cond0.72710160
89MP0000613_abnormal_salivary_gland0.72690582
90MP0003938_abnormal_ear_development0.72569741
91MP0001765_abnormal_ion_homeostasis0.72511991
92MP0004270_analgesia0.72490386
93MP0008961_abnormal_basal_metabolism0.72020364
94MP0008995_early_reproductive_senescence0.71349375
95MP0003698_abnormal_male_reproductive0.71221214
96MP0004484_altered_response_of0.71045616
97MP0003045_fibrosis0.70107320
98MP0000516_abnormal_urinary_system0.69816191
99MP0005367_renal/urinary_system_phenotyp0.69816191
100MP0005379_endocrine/exocrine_gland_phen0.69722730

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)3.80593661
2Progressive cerebellar ataxia (HP:0002073)3.54462527
3Pancreatic cysts (HP:0001737)3.29537306
4Stomach cancer (HP:0012126)3.08536458
5Hypothermia (HP:0002045)2.95983935
6Pancreatic fibrosis (HP:0100732)2.90495571
7Gaze-evoked nystagmus (HP:0000640)2.82453442
8True hermaphroditism (HP:0010459)2.79895485
9Truncal obesity (HP:0001956)2.72308237
10Agitation (HP:0000713)2.69751137
11Hyperventilation (HP:0002883)2.67374773
12Thyroiditis (HP:0100646)2.53583341
13Abnormality of the renal cortex (HP:0011035)2.52347125
14Neoplasm of the tracheobronchial system (HP:0100552)2.47999788
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47440883
16Degeneration of the lateral corticospinal tracts (HP:0002314)2.47440883
17Nephronophthisis (HP:0000090)2.39115298
18Neoplasm of the heart (HP:0100544)2.38305268
19Papillary thyroid carcinoma (HP:0002895)2.37529431
20Chronic hepatic failure (HP:0100626)2.36379007
21Abnormality of the astrocytes (HP:0100707)2.36149630
22Astrocytoma (HP:0009592)2.36149630
23Fair hair (HP:0002286)2.36054836
24Concave nail (HP:0001598)2.34389135
25Aqueductal stenosis (HP:0002410)2.33932498
26Generalized hypopigmentation of hair (HP:0011358)2.30436975
27Ependymoma (HP:0002888)2.29806704
28Abnormality of the renal medulla (HP:0100957)2.28800688
29Hip dysplasia (HP:0001385)2.23591918
30Medial flaring of the eyebrow (HP:0010747)2.22922884
31Abolished electroretinogram (ERG) (HP:0000550)2.21773318
32Volvulus (HP:0002580)2.21234624
33Ketoacidosis (HP:0001993)2.19608151
34Macroorchidism (HP:0000053)2.18739204
35Neoplasm of the adrenal cortex (HP:0100641)2.17854920
36Glioma (HP:0009733)2.17215450
37Oligodactyly (hands) (HP:0001180)2.13211849
38Alveolar cell carcinoma (HP:0006519)2.12022232
39Decreased circulating renin level (HP:0003351)2.11465825
40Febrile seizures (HP:0002373)2.10889561
41Tubulointerstitial nephritis (HP:0001970)2.07921056
42Genital tract atresia (HP:0001827)2.06379516
43Inability to walk (HP:0002540)2.05216259
44Hamartoma of the eye (HP:0010568)2.02100371
45Abnormality of the nasal septum (HP:0000419)2.00934464
46Abnormality of midbrain morphology (HP:0002418)2.00664339
47Molar tooth sign on MRI (HP:0002419)2.00664339
48Decreased central vision (HP:0007663)1.99150570
49Vaginal atresia (HP:0000148)1.94938494
50Thyroid carcinoma (HP:0002890)1.94756484
51Hypochromic microcytic anemia (HP:0004840)1.93417530
52Protruding tongue (HP:0010808)1.93370049
53Abnormal pancreas size (HP:0012094)1.92495038
54Aplasia/Hypoplasia of the tongue (HP:0010295)1.92421516
55Abnormality of the corticospinal tract (HP:0002492)1.90244982
56Cystic liver disease (HP:0006706)1.89940674
57Widely spaced teeth (HP:0000687)1.88399193
58Furrowed tongue (HP:0000221)1.86151866
59Hypoplastic iliac wings (HP:0002866)1.85515083
60Broad-based gait (HP:0002136)1.84665532
61Hamartoma (HP:0010566)1.82931064
62Poor coordination (HP:0002370)1.81095822
63Hemiplegia (HP:0002301)1.79214328
64Blue irides (HP:0000635)1.78853423
65Renal cortical cysts (HP:0000803)1.78370814
66Increased corneal curvature (HP:0100692)1.77689837
67Keratoconus (HP:0000563)1.77689837
68Gait imbalance (HP:0002141)1.76473384
69Abnormality of secondary sexual hair (HP:0009888)1.75435919
70Abnormality of the axillary hair (HP:0100134)1.75435919
71Abnormal rod and cone electroretinograms (HP:0008323)1.73889242
72Attenuation of retinal blood vessels (HP:0007843)1.73601183
73Epileptiform EEG discharges (HP:0011182)1.72049254
74Hypsarrhythmia (HP:0002521)1.71799539
75Congenital stationary night blindness (HP:0007642)1.71643970
76EEG with generalized epileptiform discharges (HP:0011198)1.70780843
77Large for gestational age (HP:0001520)1.69532843
78Pendular nystagmus (HP:0012043)1.69486181
79Narrow palate (HP:0000189)1.67449528
80Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67416216
81Male pseudohermaphroditism (HP:0000037)1.67331007
82Congenital primary aphakia (HP:0007707)1.67226010
83Congenital malformation of the right heart (HP:0011723)1.65409470
84Double outlet right ventricle (HP:0001719)1.65409470
85Dysdiadochokinesis (HP:0002075)1.64284276
86Neoplasm of striated muscle (HP:0009728)1.64040688
87Calf muscle hypertrophy (HP:0008981)1.63872549
88Urinary bladder sphincter dysfunction (HP:0002839)1.62743315
89Hypoplastic labia majora (HP:0000059)1.62523587
90Curly hair (HP:0002212)1.61476798
91Tented upper lip vermilion (HP:0010804)1.61278284
92Menstrual irregularities (HP:0000858)1.60872819
93Disproportionate short-trunk short stature (HP:0003521)1.59973962
94Severe Myopia (HP:0011003)1.59745863
95Neoplasm of the oral cavity (HP:0100649)1.59609402
96Nephrogenic diabetes insipidus (HP:0009806)1.59201112
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.59103226
98Absent/shortened dynein arms (HP:0200106)1.59103226
99Growth hormone deficiency (HP:0000824)1.59074571
100Hematochezia (HP:0002573)1.57992847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.01464600
2TRIM283.50745886
3FGFR22.46905114
4AKT32.41370155
5PINK12.23412787
6SGK22.00826764
7BMPR1B1.98244305
8TAOK31.89696815
9STK391.88415345
10NLK1.82814815
11ACVR1B1.73188057
12EPHA31.72743526
13INSRR1.72228012
14WNK31.69572640
15OXSR11.64525379
16NUAK11.60081638
17CASK1.59239955
18MAPK131.52602546
19GRK11.47036726
20ADRBK21.46236257
21SGK2231.40254356
22SGK4941.40254356
23MAP3K41.39521468
24TNK21.38266788
25TNIK1.36691298
26LATS11.31199255
27PAK31.31187844
28SGK31.28196270
29BLK1.26563138
30CAMK1G1.25550203
31FER1.18094271
32FGFR31.17407201
33MAP2K41.14010515
34YES11.10725300
35GRK61.07408268
36MAP3K21.05927105
37STK111.04650853
38CAMK1D1.04186637
39ERBB21.01167123
40IRAK10.98607502
41PTK2B0.95354169
42WNK10.93950285
43PNCK0.93445212
44ERBB30.90822576
45MATK0.88502784
46MAP4K20.87176137
47CAMKK20.86804745
48DAPK20.85965341
49TXK0.85592597
50STK380.80390575
51STK38L0.78836260
52TEC0.78652661
53SGK10.78611970
54RIPK40.78521201
55WNK40.78072302
56MARK20.74326236
57NEK60.71696109
58OBSCN0.71004390
59PRKAA20.70616476
60PKN20.70547898
61JAK10.70362185
62NTRK20.69047973
63CAMK40.68907966
64MAP2K70.65577343
65PIK3CA0.65310706
66PRKCZ0.63656930
67BRD40.63295572
68TAOK10.62219227
69ADRBK10.61005663
70NTRK30.59055431
71PRKCE0.57756769
72CAMK10.56979270
73CHUK0.56577784
74PRKCH0.54824920
75MKNK20.54636634
76IKBKE0.53249139
77PRKD20.52771470
78CSK0.51943627
79PRKAA10.47331471
80RET0.46323024
81FGFR10.45380580
82BMPR20.43674123
83STK240.43358881
84DYRK1A0.43148194
85BRSK20.42794972
86PIK3CG0.42731373
87PRKCQ0.42719755
88STK30.42615337
89SYK0.42610405
90MAP3K70.42488752
91LYN0.40910636
92ZAK0.39845083
93RPS6KB10.39186574
94BTK0.38312202
95HCK0.37996625
96PDK10.36581725
97MELK0.36367484
98MARK30.35249547
99JAK20.34654076
100PRKCG0.34517189

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.25201598
2Caffeine metabolism_Homo sapiens_hsa002322.31360102
3Dorso-ventral axis formation_Homo sapiens_hsa043202.22257060
4Nicotine addiction_Homo sapiens_hsa050331.83507597
5Type II diabetes mellitus_Homo sapiens_hsa049301.77191475
6Taste transduction_Homo sapiens_hsa047421.72123656
7Insulin secretion_Homo sapiens_hsa049111.71737256
8ABC transporters_Homo sapiens_hsa020101.65245587
9Regulation of autophagy_Homo sapiens_hsa041401.60911923
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60494447
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56639174
12Linoleic acid metabolism_Homo sapiens_hsa005911.51447631
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46574938
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41700907
15Morphine addiction_Homo sapiens_hsa050321.39346938
16Phototransduction_Homo sapiens_hsa047441.38532838
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36119220
18Circadian rhythm_Homo sapiens_hsa047101.32934940
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29409175
20Ovarian steroidogenesis_Homo sapiens_hsa049131.28199724
21Serotonergic synapse_Homo sapiens_hsa047261.27122305
22Renin secretion_Homo sapiens_hsa049241.25575076
23Glutamatergic synapse_Homo sapiens_hsa047241.23349658
24Ether lipid metabolism_Homo sapiens_hsa005651.20562899
25Circadian entrainment_Homo sapiens_hsa047131.19649949
26mTOR signaling pathway_Homo sapiens_hsa041501.18976095
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17194196
28FoxO signaling pathway_Homo sapiens_hsa040681.16173296
29Inositol phosphate metabolism_Homo sapiens_hsa005621.15525698
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10698270
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08144379
32Butanoate metabolism_Homo sapiens_hsa006501.05640193
33Prostate cancer_Homo sapiens_hsa052151.03400550
34Dopaminergic synapse_Homo sapiens_hsa047281.03139798
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03083750
36GABAergic synapse_Homo sapiens_hsa047271.02662083
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02109666
38Nitrogen metabolism_Homo sapiens_hsa009101.02066965
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02027566
40Long-term depression_Homo sapiens_hsa047301.01148547
41Olfactory transduction_Homo sapiens_hsa047400.96595312
42Calcium signaling pathway_Homo sapiens_hsa040200.96428155
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95998176
44Salivary secretion_Homo sapiens_hsa049700.93345969
45Endometrial cancer_Homo sapiens_hsa052130.92925300
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.92347273
47cAMP signaling pathway_Homo sapiens_hsa040240.91677417
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89722450
49Amphetamine addiction_Homo sapiens_hsa050310.88200568
50Prolactin signaling pathway_Homo sapiens_hsa049170.87498139
51Histidine metabolism_Homo sapiens_hsa003400.87430593
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85294246
53Insulin resistance_Homo sapiens_hsa049310.85277097
54Chemical carcinogenesis_Homo sapiens_hsa052040.85014340
55Cholinergic synapse_Homo sapiens_hsa047250.82967853
56Fatty acid biosynthesis_Homo sapiens_hsa000610.82239446
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82121897
58Choline metabolism in cancer_Homo sapiens_hsa052310.80803123
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80019766
60Melanoma_Homo sapiens_hsa052180.79589024
61Non-small cell lung cancer_Homo sapiens_hsa052230.78113099
62beta-Alanine metabolism_Homo sapiens_hsa004100.74630649
63Collecting duct acid secretion_Homo sapiens_hsa049660.74510720
64Pancreatic secretion_Homo sapiens_hsa049720.73009053
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72732979
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.71985961
67Lysine degradation_Homo sapiens_hsa003100.70589904
68Vitamin digestion and absorption_Homo sapiens_hsa049770.70319429
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70173172
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.68956553
71Glycerolipid metabolism_Homo sapiens_hsa005610.68923556
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.67434328
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66809133
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66590937
75Tryptophan metabolism_Homo sapiens_hsa003800.65781280
76Ras signaling pathway_Homo sapiens_hsa040140.64973690
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.63943870
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63304552
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62546179
80T cell receptor signaling pathway_Homo sapiens_hsa046600.62381939
81Platelet activation_Homo sapiens_hsa046110.61263438
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61200872
83Hedgehog signaling pathway_Homo sapiens_hsa043400.61000424
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60771467
85Cocaine addiction_Homo sapiens_hsa050300.60473273
86Oxytocin signaling pathway_Homo sapiens_hsa049210.59807429
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.58823772
88Gastric acid secretion_Homo sapiens_hsa049710.56180276
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54997853
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54860264
91Retinol metabolism_Homo sapiens_hsa008300.53952749
92TGF-beta signaling pathway_Homo sapiens_hsa043500.51902881
93ErbB signaling pathway_Homo sapiens_hsa040120.51170909
94Long-term potentiation_Homo sapiens_hsa047200.50527023
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50077389
96Sulfur metabolism_Homo sapiens_hsa009200.49587499
97Peroxisome_Homo sapiens_hsa041460.49222224
98Glioma_Homo sapiens_hsa052140.49124537
99Axon guidance_Homo sapiens_hsa043600.47644118
100Gap junction_Homo sapiens_hsa045400.47237182

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