ZNF648

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1otic vesicle formation (GO:0030916)5.43230336
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.60307869
3G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.51186740
4cilium or flagellum-dependent cell motility (GO:0001539)4.48154791
5epithelial cilium movement (GO:0003351)4.32346444
6photoreceptor cell differentiation (GO:0046530)4.11872705
7eye photoreceptor cell differentiation (GO:0001754)4.11872705
8axonemal dynein complex assembly (GO:0070286)4.08023686
9positive regulation of male gonad development (GO:2000020)3.96164539
10oxidative demethylation (GO:0070989)3.77147897
11cilium movement (GO:0003341)3.74315187
12nuclear pore complex assembly (GO:0051292)3.60943508
13nonmotile primary cilium assembly (GO:0035058)3.58289275
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.54714285
15regulation of translation, ncRNA-mediated (GO:0045974)3.54714285
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.54714285
17L-serine metabolic process (GO:0006563)3.51985151
18protein polyglutamylation (GO:0018095)3.36297082
19centriole replication (GO:0007099)3.30045274
20DNA replication initiation (GO:0006270)3.29993836
21notochord development (GO:0030903)3.27369842
22sperm motility (GO:0030317)3.23038598
23regulation of posttranscriptional gene silencing (GO:0060147)3.15182422
24regulation of gene silencing by miRNA (GO:0060964)3.15182422
25regulation of gene silencing by RNA (GO:0060966)3.15182422
26nuclear pore organization (GO:0006999)3.14995297
27regulation of telomere maintenance via telomerase (GO:0032210)3.05888581
28response to nitrosative stress (GO:0051409)3.05491399
29regulation of male gonad development (GO:2000018)3.02918752
30pre-miRNA processing (GO:0031054)3.00049450
31negative regulation of cardiac muscle tissue development (GO:0055026)2.99458546
32regulation of helicase activity (GO:0051095)2.98291720
33establishment of protein localization to Golgi (GO:0072600)2.93119045
34fusion of sperm to egg plasma membrane (GO:0007342)2.92982673
35single strand break repair (GO:0000012)2.92751199
36lysine metabolic process (GO:0006553)2.91729223
37lysine catabolic process (GO:0006554)2.91729223
38polyamine biosynthetic process (GO:0006596)2.88498616
39DNA replication-dependent nucleosome organization (GO:0034723)2.87212891
40DNA replication-dependent nucleosome assembly (GO:0006335)2.87212891
41embryonic retina morphogenesis in camera-type eye (GO:0060059)2.85649156
42regulation of cell fate specification (GO:0042659)2.85647009
43organ induction (GO:0001759)2.83711965
44photoreceptor cell maintenance (GO:0045494)2.77328909
45cellular biogenic amine biosynthetic process (GO:0042401)2.76552128
46chromatin silencing (GO:0006342)2.75513461
47regulation of cilium movement (GO:0003352)2.74895179
48epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72995789
49microtubule polymerization or depolymerization (GO:0031109)2.72696217
50protein targeting to Golgi (GO:0000042)2.72475771
51centriole assembly (GO:0098534)2.69888747
52negative regulation of JUN kinase activity (GO:0043508)2.67117511
53centrosome duplication (GO:0051298)2.64594364
54retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64009935
55microtubule depolymerization (GO:0007019)2.62515186
56double-strand break repair via nonhomologous end joining (GO:0006303)2.61443926
57non-recombinational repair (GO:0000726)2.61443926
58ephrin receptor signaling pathway (GO:0048013)2.57001202
59amine biosynthetic process (GO:0009309)2.56379356
60DNA demethylation (GO:0080111)2.56342430
61amine catabolic process (GO:0009310)2.55810837
62cellular biogenic amine catabolic process (GO:0042402)2.55810837
63imidazole-containing compound metabolic process (GO:0052803)2.55377018
64intraciliary transport (GO:0042073)2.54012430
65resolution of meiotic recombination intermediates (GO:0000712)2.52775349
66microtubule severing (GO:0051013)2.52308109
67body morphogenesis (GO:0010171)2.50868140
68cilium assembly (GO:0042384)2.50012413
694-hydroxyproline metabolic process (GO:0019471)2.48905505
70cell migration involved in gastrulation (GO:0042074)2.47985275
71axon extension involved in axon guidance (GO:0048846)2.46159536
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.46159536
73embryonic body morphogenesis (GO:0010172)2.44428709
74spermatid development (GO:0007286)2.42451266
75motile cilium assembly (GO:0044458)2.42436356
76estrogen biosynthetic process (GO:0006703)2.41545642
77cilium organization (GO:0044782)2.40597314
78regulation of gene silencing (GO:0060968)2.37442527
79S-adenosylmethionine metabolic process (GO:0046500)2.37166783
80aspartate family amino acid catabolic process (GO:0009068)2.36687233
81DNA double-strand break processing (GO:0000729)2.36042173
82left/right pattern formation (GO:0060972)2.35149947
83DNA duplex unwinding (GO:0032508)2.34366991
84establishment of nucleus localization (GO:0040023)2.34176598
85histone arginine methylation (GO:0034969)2.33814659
86calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.33201505
87protein localization to synapse (GO:0035418)2.32806480
88cell proliferation in forebrain (GO:0021846)2.32384705
89DNA geometric change (GO:0032392)2.31634336
90negative regulation of DNA recombination (GO:0045910)2.31494381
91kynurenine metabolic process (GO:0070189)2.30820084
92developmental induction (GO:0031128)2.30425407
93pore complex assembly (GO:0046931)2.29314650
94glycine metabolic process (GO:0006544)2.29266643
95rRNA methylation (GO:0031167)2.29248851
96sterol biosynthetic process (GO:0016126)2.28502817
97serine family amino acid catabolic process (GO:0009071)2.27988085
98smoothened signaling pathway (GO:0007224)2.26934326
99serine family amino acid biosynthetic process (GO:0009070)2.26800091
100lateral ventricle development (GO:0021670)2.26514268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.45424930
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.37078187
3TAF15_26573619_Chip-Seq_HEK293_Human2.87872837
4NANOG_16153702_ChIP-ChIP_HESCs_Human2.63713172
5* ZNF274_21170338_ChIP-Seq_K562_Hela2.56304297
6IRF1_19129219_ChIP-ChIP_H3396_Human2.43035937
7FUS_26573619_Chip-Seq_HEK293_Human2.30923394
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27595522
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.27595522
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.21074489
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18074933
12AR_21909140_ChIP-Seq_LNCAP_Human2.11737633
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.10351833
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98974218
15SOX2_16153702_ChIP-ChIP_HESCs_Human1.97127415
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96845850
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96824341
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95665281
19IGF1R_20145208_ChIP-Seq_DFB_Human1.90887948
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89527997
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88193957
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81148870
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73580816
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.73154288
25GBX2_23144817_ChIP-Seq_PC3_Human1.70897235
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70038421
27EWS_26573619_Chip-Seq_HEK293_Human1.69076563
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68675101
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67861156
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66126959
31MYC_18940864_ChIP-ChIP_HL60_Human1.63778284
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62666803
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61515122
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.57838942
35VDR_22108803_ChIP-Seq_LS180_Human1.57385155
36STAT3_23295773_ChIP-Seq_U87_Human1.53927350
37* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51601103
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51272781
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48883309
40CBP_20019798_ChIP-Seq_JUKART_Human1.48883309
41P300_19829295_ChIP-Seq_ESCs_Human1.45246780
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44447614
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44362652
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41960871
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34942292
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31243384
47RNF2_27304074_Chip-Seq_NSC_Mouse1.30764313
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27019622
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.24332031
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.22064195
51RUNX2_22187159_ChIP-Seq_PCA_Human1.21294854
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.21133849
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18846462
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18538064
55NANOG_19829295_ChIP-Seq_ESCs_Human1.17448029
56SOX2_19829295_ChIP-Seq_ESCs_Human1.17448029
57* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16102374
58RXR_22108803_ChIP-Seq_LS180_Human1.15397448
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14349296
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.11860374
61SMAD4_21799915_ChIP-Seq_A2780_Human1.11642365
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.11355494
63TCF4_23295773_ChIP-Seq_U87_Human1.10030331
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09702336
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09702336
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09702336
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09394498
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09224015
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08582189
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.08190161
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07797135
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06467550
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06239049
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.04825024
75* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03886017
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01990224
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00620178
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99479641
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98308464
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97663220
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97440917
82AR_19668381_ChIP-Seq_PC3_Human0.96787348
83TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96431909
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95786232
85HOXB7_26014856_ChIP-Seq_BT474_Human0.94586390
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94498722
87TCF4_22108803_ChIP-Seq_LS180_Human0.93844192
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.93743551
89* SOX2_21211035_ChIP-Seq_LN229_Gbm0.93483787
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92894528
91LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92203617
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91405801
93SOX9_26525672_Chip-Seq_HEART_Mouse0.91144738
94E2F1_21310950_ChIP-Seq_MCF-7_Human0.89673911
95TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89577389
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89009528
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87924945
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.87820777
99TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87764358
100FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86851085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.33767309
2MP0008057_abnormal_DNA_replication4.07973606
3MP0008877_abnormal_DNA_methylation3.32144110
4MP0005377_hearing/vestibular/ear_phenot3.27775971
5MP0003878_abnormal_ear_physiology3.27775971
6MP0001529_abnormal_vocalization2.81727356
7MP0002102_abnormal_ear_morphology2.50417604
8MP0000678_abnormal_parathyroid_gland2.31636684
9MP0003937_abnormal_limbs/digits/tail_de2.27740882
10MP0001293_anophthalmia2.27627107
11MP0003880_abnormal_central_pattern2.21786261
12MP0002938_white_spotting2.13960107
13MP0003693_abnormal_embryo_hatching2.13233499
14MP0000566_synostosis2.01815642
15MP0008875_abnormal_xenobiotic_pharmacok1.95853213
16MP0003136_yellow_coat_color1.95587346
17MP0000383_abnormal_hair_follicle1.92229566
18MP0008789_abnormal_olfactory_epithelium1.90978284
19MP0001485_abnormal_pinna_reflex1.86808335
20MP0002233_abnormal_nose_morphology1.83616919
21MP0003718_maternal_effect1.74801511
22MP0008058_abnormal_DNA_repair1.69974741
23MP0005394_taste/olfaction_phenotype1.68700966
24MP0005499_abnormal_olfactory_system1.68700966
25MP0000049_abnormal_middle_ear1.66190585
26MP0003567_abnormal_fetal_cardiomyocyte1.60810879
27MP0008932_abnormal_embryonic_tissue1.59002111
28MP0006054_spinal_hemorrhage1.54165512
29MP0005083_abnormal_biliary_tract1.50214295
30MP0003077_abnormal_cell_cycle1.49440441
31MP0008007_abnormal_cellular_replicative1.49178880
32MP0005410_abnormal_fertilization1.48650320
33MP0006276_abnormal_autonomic_nervous1.48630871
34MP0002249_abnormal_larynx_morphology1.46706118
35MP0001984_abnormal_olfaction1.46073545
36MP0009672_abnormal_birth_weight1.44262916
37MP0010030_abnormal_orbit_morphology1.43907037
38MP0010094_abnormal_chromosome_stability1.40055517
39MP0002254_reproductive_system_inflammat1.37195800
40MP0002697_abnormal_eye_size1.36789603
41MP0010678_abnormal_skin_adnexa1.34368610
42MP0004197_abnormal_fetal_growth/weight/1.33730810
43MP0000579_abnormal_nail_morphology1.30666266
44MP0002009_preneoplasia1.30390468
45MP0005670_abnormal_white_adipose1.26719415
46MP0000647_abnormal_sebaceous_gland1.25242710
47MP0002282_abnormal_trachea_morphology1.24200196
48MP0001929_abnormal_gametogenesis1.21833679
49MP0003121_genomic_imprinting1.20403468
50MP0002653_abnormal_ependyma_morphology1.20253133
51MP0006292_abnormal_olfactory_placode1.19949825
52MP0001299_abnormal_eye_distance/1.15883241
53MP0003123_paternal_imprinting1.11255484
54MP0005551_abnormal_eye_electrophysiolog1.10226840
55MP0003111_abnormal_nucleus_morphology1.10145388
56MP0009697_abnormal_copulation1.10046952
57MP0004133_heterotaxia1.09760348
58MP0003698_abnormal_male_reproductive1.08776996
59MP0003941_abnormal_skin_development1.06207203
60MP0006072_abnormal_retinal_apoptosis1.05032478
61MP0002084_abnormal_developmental_patter1.03503878
62MP0001286_abnormal_eye_development1.03074195
63MP0002085_abnormal_embryonic_tissue1.02022975
64MP0002092_abnormal_eye_morphology1.00718589
65MP0000372_irregular_coat_pigmentation0.99993121
66MP0004957_abnormal_blastocyst_morpholog0.99518910
67MP0003890_abnormal_embryonic-extraembry0.95795573
68MP0006035_abnormal_mitochondrial_morpho0.92792568
69MP0009703_decreased_birth_body0.92031526
70MP0004272_abnormal_basement_membrane0.90653740
71MP0005408_hypopigmentation0.90305417
72MP0000428_abnormal_craniofacial_morphol0.89247153
73MP0005248_abnormal_Harderian_gland0.88470353
74MP0003861_abnormal_nervous_system0.88311059
75MP0003942_abnormal_urinary_system0.87858944
76MP0010352_gastrointestinal_tract_polyps0.87747764
77MP0001963_abnormal_hearing_physiology0.86153290
78MP0005391_vision/eye_phenotype0.85445888
79MP0005085_abnormal_gallbladder_physiolo0.84192220
80MP0003755_abnormal_palate_morphology0.83584906
81MP0002557_abnormal_social/conspecific_i0.83100554
82MP0003119_abnormal_digestive_system0.83005718
83MP0002127_abnormal_cardiovascular_syste0.82534551
84MP0000026_abnormal_inner_ear0.82446271
85MP0002736_abnormal_nociception_after0.80006434
86MP0003787_abnormal_imprinting0.79572345
87MP0005253_abnormal_eye_physiology0.79568285
88MP0000653_abnormal_sex_gland0.79313869
89MP0001324_abnormal_eye_pigmentation0.78932555
90MP0005395_other_phenotype0.78524647
91MP0002161_abnormal_fertility/fecundity0.77160437
92MP0002210_abnormal_sex_determination0.75022984
93MP0002160_abnormal_reproductive_system0.73561809
94MP0001145_abnormal_male_reproductive0.73255412
95MP0001672_abnormal_embryogenesis/_devel0.73016841
96MP0005380_embryogenesis_phenotype0.73016841
97MP0002111_abnormal_tail_morphology0.72052989
98MP0004147_increased_porphyrin_level0.70792125
99MP0001486_abnormal_startle_reflex0.66299384
100MP0005171_absent_coat_pigmentation0.66225642

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.32277479
2Atonic seizures (HP:0010819)4.15213056
3Tubulointerstitial nephritis (HP:0001970)4.11597415
4Abnormality of cochlea (HP:0000375)3.65465930
5Colon cancer (HP:0003003)3.61877352
6Abnormal respiratory epithelium morphology (HP:0012253)3.61769249
7Abnormal respiratory motile cilium morphology (HP:0005938)3.61769249
8Urethral obstruction (HP:0000796)3.58489259
9Absent epiphyses (HP:0010577)3.34697013
10Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.34697013
11Increased serum pyruvate (HP:0003542)3.32344452
12Abnormality of glycolysis (HP:0004366)3.29628421
13Breast aplasia (HP:0100783)3.29064319
14Abnormal ciliary motility (HP:0012262)3.19557207
15Absent/shortened dynein arms (HP:0200106)3.18819916
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.18819916
17Aplasia/Hypoplasia of the breasts (HP:0010311)3.11707098
18Morphological abnormality of the inner ear (HP:0011390)2.97558017
19Abnormal respiratory motile cilium physiology (HP:0012261)2.77955050
20Pancreatic cysts (HP:0001737)2.73959260
21Rhinitis (HP:0012384)2.69657704
22Occipital encephalocele (HP:0002085)2.68597785
23Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54162842
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47529245
25Congenital primary aphakia (HP:0007707)2.43887689
26Pancreatic fibrosis (HP:0100732)2.42974590
27Irregular epiphyses (HP:0010582)2.42191901
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40290561
29Cystic liver disease (HP:0006706)2.39330315
30Abnormality of the labia minora (HP:0012880)2.37117265
31Gait imbalance (HP:0002141)2.36684229
32Sex reversal (HP:0012245)2.36574321
33Abnormal sex determination (HP:0012244)2.36574321
34High anterior hairline (HP:0009890)2.33865899
35Microvesicular hepatic steatosis (HP:0001414)2.28998093
36Bifid scrotum (HP:0000048)2.26681331
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.24383406
38Fibular hypoplasia (HP:0003038)2.21636074
39Hyperglycinemia (HP:0002154)2.21565999
40Postaxial foot polydactyly (HP:0001830)2.20093343
41Erectile abnormalities (HP:0100639)2.16948659
42Medial flaring of the eyebrow (HP:0010747)2.15878681
43Chromsome breakage (HP:0040012)2.15019552
44Aplasia/Hypoplasia of the fibula (HP:0006492)2.11264692
45Poor coordination (HP:0002370)2.04859011
46Reticulocytosis (HP:0001923)2.04777783
47Depressed nasal tip (HP:0000437)2.03129019
48Broad foot (HP:0001769)2.02675550
49Meckel diverticulum (HP:0002245)2.02097307
50Nephrogenic diabetes insipidus (HP:0009806)2.00225796
51Abnormal biliary tract physiology (HP:0012439)1.99151232
52Bile duct proliferation (HP:0001408)1.99151232
53Preaxial foot polydactyly (HP:0001841)1.98261857
54Supernumerary spleens (HP:0009799)1.98002867
55Birth length less than 3rd percentile (HP:0003561)1.96306762
56Bifid tongue (HP:0010297)1.94776555
57Urinary bladder sphincter dysfunction (HP:0002839)1.92445390
58Sclerocornea (HP:0000647)1.92223807
59Genetic anticipation (HP:0003743)1.92047694
60Preaxial hand polydactyly (HP:0001177)1.91704278
61Bony spicule pigmentary retinopathy (HP:0007737)1.91187104
62Chronic bronchitis (HP:0004469)1.89000360
63Carpal bone hypoplasia (HP:0001498)1.88665889
64Chronic hepatic failure (HP:0100626)1.88091055
65Abnormality of methionine metabolism (HP:0010901)1.87861671
66Hypoplasia of the pons (HP:0012110)1.87271138
67Abnormality of the ileum (HP:0001549)1.86720049
68Abnormality of sulfur amino acid metabolism (HP:0004339)1.85814904
69Broad phalanges of the hand (HP:0009768)1.84894652
70Morphological abnormality of the pyramidal tract (HP:0002062)1.84345799
71Male pseudohermaphroditism (HP:0000037)1.84343263
72Neonatal short-limb short stature (HP:0008921)1.84318393
73Scrotal hypoplasia (HP:0000046)1.83504531
74Broad thumb (HP:0011304)1.82671646
75Broad distal phalanx of finger (HP:0009836)1.81067986
76Exercise-induced muscle cramps (HP:0003710)1.80298979
77Hypotelorism (HP:0000601)1.80259623
78Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77118852
79Vaginal atresia (HP:0000148)1.75489485
80Nephroblastoma (Wilms tumor) (HP:0002667)1.75120786
81Anencephaly (HP:0002323)1.74239521
82Ectopic kidney (HP:0000086)1.72868760
83Optic nerve coloboma (HP:0000588)1.72680759
84Primary amenorrhea (HP:0000786)1.70891574
85Broad finger (HP:0001500)1.70799520
86Medulloblastoma (HP:0002885)1.69729607
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69670378
88Holoprosencephaly (HP:0001360)1.69159242
89Sloping forehead (HP:0000340)1.69049157
90Pancreatic islet-cell hyperplasia (HP:0004510)1.68584096
91Labial hypoplasia (HP:0000066)1.68431518
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.68402620
93Abnormality of glycine metabolism (HP:0010895)1.68362999
94Abnormality of serine family amino acid metabolism (HP:0010894)1.68362999
95Dandy-Walker malformation (HP:0001305)1.68047076
96Abnormality of the corticospinal tract (HP:0002492)1.67003496
97Gynecomastia (HP:0000771)1.66869677
98Genital tract atresia (HP:0001827)1.65185170
99Type II lissencephaly (HP:0007260)1.64834946
100Anosmia (HP:0000458)1.64652079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.79723549
2SRPK13.19746223
3CDK193.13324671
4BRSK23.07240342
5PLK42.93864779
6TNIK2.84269411
7EPHA42.81714134
8TSSK62.57876974
9MST42.49182838
10WEE12.37365265
11MKNK12.29641612
12CDC72.27787773
13BRD42.18072898
14DYRK32.16932891
15BRSK12.11537738
16TTK2.08367920
17FRK2.08228050
18PLK22.02806605
19PNCK1.98725062
20MKNK21.74978565
21TRIM281.64862080
22EPHA21.64622557
23ICK1.60819117
24ZAK1.52199920
25MAP3K101.49425278
26MAPK151.40518266
27BCR1.39450011
28PLK31.39316698
29WNK41.37502212
30MAP3K41.35797534
31DYRK1B1.32223895
32STK391.20233676
33VRK11.19607409
34GRK11.19423606
35SIK31.18554114
36NUAK11.18277669
37OXSR11.12109667
38PLK11.10719143
39INSRR1.10367311
40TYRO31.10092328
41CAMK1G0.95249804
42FER0.94900179
43TAF10.94623342
44DYRK1A0.92846403
45MAP2K70.90221661
46ATR0.89704596
47CASK0.86408967
48CDK70.84581386
49STK38L0.84446952
50PRKD30.83665005
51TIE10.81701653
52PASK0.79358255
53EEF2K0.76487462
54CSNK1A1L0.75305738
55ATM0.74039433
56CDK120.72326493
57FGFR10.70499889
58CAMK1D0.70134273
59CSNK1G10.67201996
60PAK40.64239344
61BUB10.62483974
62TGFBR10.62095029
63PRKCE0.61445265
64ERBB20.59915430
65CHEK20.57918893
66PRKCG0.56703127
67DYRK20.55195692
68CSNK1G30.55048355
69CHEK10.53230576
70MELK0.50678641
71STK380.50542106
72RPS6KA40.49942930
73CDK90.49134631
74NTRK30.48104995
75STK30.47190681
76NLK0.45177833
77CSNK1G20.44607121
78NEK10.43943585
79EIF2AK10.43162647
80PRKAA20.43130892
81CDK10.42661852
82MAP3K20.41426631
83CDK20.39551942
84MET0.39086015
85PRKAA10.38910540
86LATS10.38524317
87ERBB30.37402281
88BMPR1B0.35443313
89AKT20.34646704
90DMPK0.33284439
91TEC0.31831891
92SGK4940.31375637
93SGK2230.31375637
94CSNK1A10.31208093
95PKN10.28601982
96NME10.28561416
97ADRBK20.28132396
98YES10.28109319
99SGK30.26574665
100CAMK40.25684439

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97869258
2Steroid biosynthesis_Homo sapiens_hsa001002.55823893
3Propanoate metabolism_Homo sapiens_hsa006402.26779663
4Butanoate metabolism_Homo sapiens_hsa006502.23527508
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00831030
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98144404
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94468285
8Biosynthesis of amino acids_Homo sapiens_hsa012301.93294605
9Pyruvate metabolism_Homo sapiens_hsa006201.90431525
10Caffeine metabolism_Homo sapiens_hsa002321.88299994
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87427972
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84398836
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.84383317
14Non-homologous end-joining_Homo sapiens_hsa034501.82216078
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.75669632
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74277041
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73926997
18DNA replication_Homo sapiens_hsa030301.73035271
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66577823
20Selenocompound metabolism_Homo sapiens_hsa004501.65412634
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62875899
22Arginine and proline metabolism_Homo sapiens_hsa003301.61253786
23Histidine metabolism_Homo sapiens_hsa003401.56858124
24Tryptophan metabolism_Homo sapiens_hsa003801.51772138
25Carbon metabolism_Homo sapiens_hsa012001.50874922
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42135578
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.41907458
28RNA transport_Homo sapiens_hsa030131.40744753
29Mismatch repair_Homo sapiens_hsa034301.39393025
30One carbon pool by folate_Homo sapiens_hsa006701.34937712
31Taste transduction_Homo sapiens_hsa047421.34321708
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33736291
33Nitrogen metabolism_Homo sapiens_hsa009101.32992299
34beta-Alanine metabolism_Homo sapiens_hsa004101.32048224
35Fatty acid degradation_Homo sapiens_hsa000711.30859972
36Fatty acid metabolism_Homo sapiens_hsa012121.30279502
37Tyrosine metabolism_Homo sapiens_hsa003501.29731566
38Base excision repair_Homo sapiens_hsa034101.28082054
39Lysine degradation_Homo sapiens_hsa003101.25711315
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.23070680
41Fat digestion and absorption_Homo sapiens_hsa049751.22305292
42Basal cell carcinoma_Homo sapiens_hsa052171.20461468
43Phenylalanine metabolism_Homo sapiens_hsa003601.20247663
44Retinol metabolism_Homo sapiens_hsa008301.19568865
45Fatty acid elongation_Homo sapiens_hsa000621.18994003
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.18597237
47RNA polymerase_Homo sapiens_hsa030201.18159994
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10330811
49Arginine biosynthesis_Homo sapiens_hsa002201.09719201
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08024048
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07731116
52Linoleic acid metabolism_Homo sapiens_hsa005911.06210927
53Sulfur relay system_Homo sapiens_hsa041221.04618483
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.04396535
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03306133
56Chemical carcinogenesis_Homo sapiens_hsa052041.00332971
57mRNA surveillance pathway_Homo sapiens_hsa030150.94404767
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93177290
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89328340
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88399775
61Fanconi anemia pathway_Homo sapiens_hsa034600.86358515
62Homologous recombination_Homo sapiens_hsa034400.85792597
63Basal transcription factors_Homo sapiens_hsa030220.85426825
64Cell cycle_Homo sapiens_hsa041100.81867265
65ABC transporters_Homo sapiens_hsa020100.80361625
66Hippo signaling pathway_Homo sapiens_hsa043900.79906244
67Nicotine addiction_Homo sapiens_hsa050330.79174937
68Vitamin B6 metabolism_Homo sapiens_hsa007500.78935344
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.78687589
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78411773
71Phototransduction_Homo sapiens_hsa047440.76780559
72Peroxisome_Homo sapiens_hsa041460.73664887
73Bile secretion_Homo sapiens_hsa049760.71578038
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70201455
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68622407
76Complement and coagulation cascades_Homo sapiens_hsa046100.66787360
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65944951
78Tight junction_Homo sapiens_hsa045300.65467779
79Nucleotide excision repair_Homo sapiens_hsa034200.65103394
80Metabolic pathways_Homo sapiens_hsa011000.63073390
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62928510
82Fatty acid biosynthesis_Homo sapiens_hsa000610.62802522
83Glutathione metabolism_Homo sapiens_hsa004800.62315371
84Spliceosome_Homo sapiens_hsa030400.59076980
85Wnt signaling pathway_Homo sapiens_hsa043100.58516752
86Purine metabolism_Homo sapiens_hsa002300.58167480
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58083170
88Hedgehog signaling pathway_Homo sapiens_hsa043400.57689799
89RNA degradation_Homo sapiens_hsa030180.53880005
90Fructose and mannose metabolism_Homo sapiens_hsa000510.53554583
91Starch and sucrose metabolism_Homo sapiens_hsa005000.52770761
92Arachidonic acid metabolism_Homo sapiens_hsa005900.52675715
93Adherens junction_Homo sapiens_hsa045200.51850520
94Vitamin digestion and absorption_Homo sapiens_hsa049770.49168910
95Olfactory transduction_Homo sapiens_hsa047400.48350206
96N-Glycan biosynthesis_Homo sapiens_hsa005100.48189650
97Pyrimidine metabolism_Homo sapiens_hsa002400.47880985
98Axon guidance_Homo sapiens_hsa043600.41709446
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38896426
100Glucagon signaling pathway_Homo sapiens_hsa049220.38444920

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