ZNF625

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)3.71486322
2behavioral response to nicotine (GO:0035095)3.57004163
3CENP-A containing nucleosome assembly (GO:0034080)3.42670681
4DNA double-strand break processing (GO:0000729)3.39990523
5regulation of timing of cell differentiation (GO:0048505)3.39614685
6regulation of nuclear cell cycle DNA replication (GO:0033262)3.34541959
7presynaptic membrane assembly (GO:0097105)3.27037817
8replication fork processing (GO:0031297)3.25755720
9protein neddylation (GO:0045116)3.20063979
10regulation of development, heterochronic (GO:0040034)3.19276482
11limb bud formation (GO:0060174)3.17149082
12pyrimidine nucleobase catabolic process (GO:0006208)3.15759724
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.14878768
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10575984
15regulation of meiosis I (GO:0060631)3.09938955
16histone exchange (GO:0043486)3.09560476
17somite development (GO:0061053)3.09457082
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06116885
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00671566
20epithelial cilium movement (GO:0003351)2.98613450
21intraciliary transport (GO:0042073)2.91656606
22protein K6-linked ubiquitination (GO:0085020)2.89140775
23protein-cofactor linkage (GO:0018065)2.89107183
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87224434
25negative regulation of translation, ncRNA-mediated (GO:0040033)2.87224434
26regulation of translation, ncRNA-mediated (GO:0045974)2.87224434
27presynaptic membrane organization (GO:0097090)2.86218978
28retinal ganglion cell axon guidance (GO:0031290)2.85377963
29cell proliferation in forebrain (GO:0021846)2.83136802
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80686473
31mitochondrial respiratory chain complex I assembly (GO:0032981)2.80686473
32NADH dehydrogenase complex assembly (GO:0010257)2.80686473
33proteasome assembly (GO:0043248)2.79526337
34protein complex biogenesis (GO:0070271)2.77109955
35somite rostral/caudal axis specification (GO:0032525)2.76345237
36kidney morphogenesis (GO:0060993)2.75917654
37establishment of protein localization to mitochondrial membrane (GO:0090151)2.74826787
38regulation of centriole replication (GO:0046599)2.74205254
39mitochondrial respiratory chain complex assembly (GO:0033108)2.71579375
40centriole replication (GO:0007099)2.70311682
41chaperone-mediated protein transport (GO:0072321)2.70200144
42nonmotile primary cilium assembly (GO:0035058)2.69179278
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68481837
44hindbrain development (GO:0030902)2.67079514
45nucleobase catabolic process (GO:0046113)2.59806058
46olfactory bulb development (GO:0021772)2.59786779
47cornea development in camera-type eye (GO:0061303)2.59762919
48DNA replication-independent nucleosome organization (GO:0034724)2.59759947
49DNA replication-independent nucleosome assembly (GO:0006336)2.59759947
50recombinational repair (GO:0000725)2.57003306
51neuron cell-cell adhesion (GO:0007158)2.56763450
52cilium morphogenesis (GO:0060271)2.55907978
53reciprocal DNA recombination (GO:0035825)2.55005400
54reciprocal meiotic recombination (GO:0007131)2.55005400
55forebrain neuron differentiation (GO:0021879)2.54735798
56double-strand break repair via homologous recombination (GO:0000724)2.54135431
57synapsis (GO:0007129)2.52847702
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52439188
59neural tube formation (GO:0001841)2.52261452
60negative regulation of DNA recombination (GO:0045910)2.51610012
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50843793
62regulation of mitotic spindle checkpoint (GO:1903504)2.50843793
63DNA damage response, detection of DNA damage (GO:0042769)2.50542644
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50199904
65resolution of meiotic recombination intermediates (GO:0000712)2.46875662
66DNA replication checkpoint (GO:0000076)2.46137263
67regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.41418843
68ATP synthesis coupled proton transport (GO:0015986)2.40261626
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.40261626
70platelet dense granule organization (GO:0060155)2.36578095
71otic vesicle formation (GO:0030916)2.36340083
72positive regulation of gastrulation (GO:2000543)2.35148813
73protein prenylation (GO:0018342)2.33609509
74prenylation (GO:0097354)2.33609509
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31035749
76respiratory chain complex IV assembly (GO:0008535)2.30941183
77negative regulation of transcription regulatory region DNA binding (GO:2000678)2.30184378
78cullin deneddylation (GO:0010388)2.29922172
79thalamus development (GO:0021794)2.28805070
80cilium organization (GO:0044782)2.28636355
81water-soluble vitamin biosynthetic process (GO:0042364)2.27336287
82regulation of DNA endoreduplication (GO:0032875)2.27261840
83cilium movement (GO:0003341)2.26923016
84intra-S DNA damage checkpoint (GO:0031573)2.26665230
85postreplication repair (GO:0006301)2.26329390
86postsynaptic membrane organization (GO:0001941)2.26064743
87regulation of telomere maintenance (GO:0032204)2.25752674
88protein localization to cilium (GO:0061512)2.25734041
89regulation of helicase activity (GO:0051095)2.24921086
90protein polyglutamylation (GO:0018095)2.24484020
91spinal cord motor neuron differentiation (GO:0021522)2.24038887
92regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24000226
93histone mRNA metabolic process (GO:0008334)2.23788658
94DNA replication-dependent nucleosome organization (GO:0034723)2.22655571
95DNA replication-dependent nucleosome assembly (GO:0006335)2.22655571
96cilium assembly (GO:0042384)2.22332823
97photoreceptor cell development (GO:0042461)2.22324578
98ncRNA catabolic process (GO:0034661)2.21180499
99regulation of mesoderm development (GO:2000380)2.21021020
100regulation of gene silencing by miRNA (GO:0060964)2.20441932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.31305428
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93855291
3VDR_22108803_ChIP-Seq_LS180_Human2.67776917
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.66013640
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59390931
6FUS_26573619_Chip-Seq_HEK293_Human2.57374351
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51054246
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49865549
9EZH2_22144423_ChIP-Seq_EOC_Human2.43886216
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40858639
11GBX2_23144817_ChIP-Seq_PC3_Human2.33522694
12IGF1R_20145208_ChIP-Seq_DFB_Human2.33109120
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32783486
14TAF15_26573619_Chip-Seq_HEK293_Human2.30414072
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30053421
16EWS_26573619_Chip-Seq_HEK293_Human2.28749057
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.28069909
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.23693493
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20942796
20P300_19829295_ChIP-Seq_ESCs_Human2.11854564
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.10540360
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.04865221
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03573550
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97454011
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90078364
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84054269
27ELK1_19687146_ChIP-ChIP_HELA_Human1.80651398
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74240345
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73886072
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73081928
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.61869395
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60789004
33IRF1_19129219_ChIP-ChIP_H3396_Human1.53349379
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.51936397
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48427005
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48427005
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47610413
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47326220
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47003645
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.44916062
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43341794
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.41830574
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41798615
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.41688603
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41422038
46MYC_18940864_ChIP-ChIP_HL60_Human1.39544709
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39286302
48SMAD4_21799915_ChIP-Seq_A2780_Human1.38683112
49RNF2_27304074_Chip-Seq_NSC_Mouse1.38338629
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37743520
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37318706
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35398618
53CBP_20019798_ChIP-Seq_JUKART_Human1.34935537
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34935537
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33290290
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33075584
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29113298
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26826084
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24773410
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23592897
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21356703
62ER_23166858_ChIP-Seq_MCF-7_Human1.21009869
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.20059446
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.18972252
65BCAT_22108803_ChIP-Seq_LS180_Human1.18799282
66TP53_22573176_ChIP-Seq_HFKS_Human1.18568660
67STAT3_23295773_ChIP-Seq_U87_Human1.16159716
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15659997
69VDR_23849224_ChIP-Seq_CD4+_Human1.14999614
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14751263
71AR_25329375_ChIP-Seq_VCAP_Human1.14002385
72TCF4_23295773_ChIP-Seq_U87_Human1.12803432
73E2F7_22180533_ChIP-Seq_HELA_Human1.12163191
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.11900198
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10415046
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08538812
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08463748
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08242899
79SOX2_19829295_ChIP-Seq_ESCs_Human1.07578666
80NANOG_19829295_ChIP-Seq_ESCs_Human1.07578666
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.07184161
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06689981
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.05782672
84TCF4_22108803_ChIP-Seq_LS180_Human1.04972928
85RUNX2_22187159_ChIP-Seq_PCA_Human1.04304274
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02932943
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02562563
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01387451
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01223794
90REST_21632747_ChIP-Seq_MESCs_Mouse1.01169082
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01006679
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.00858493
93AR_21572438_ChIP-Seq_LNCaP_Human1.00532823
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98980616
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98784829
96EZH2_27304074_Chip-Seq_ESCs_Mouse0.98775318
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.96528108
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95970589
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91424446
100P53_22387025_ChIP-Seq_ESCs_Mouse0.91189527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.75690720
2MP0008877_abnormal_DNA_methylation3.04692740
3MP0003787_abnormal_imprinting2.87864371
4MP0002102_abnormal_ear_morphology2.55552664
5MP0002822_catalepsy2.45944784
6MP0003890_abnormal_embryonic-extraembry2.39621823
7MP0002938_white_spotting2.33111897
8MP0002638_abnormal_pupillary_reflex2.26722036
9MP0003121_genomic_imprinting2.25063679
10MP0001529_abnormal_vocalization2.20468571
11MP0008789_abnormal_olfactory_epithelium2.19446667
12MP0003880_abnormal_central_pattern2.12255038
13MP0003136_yellow_coat_color1.94847065
14MP0000778_abnormal_nervous_system1.90181048
15MP0003122_maternal_imprinting1.89166535
16MP0004133_heterotaxia1.85978646
17MP0001293_anophthalmia1.84527482
18MP0008058_abnormal_DNA_repair1.83823083
19MP0005394_taste/olfaction_phenotype1.81484744
20MP0005499_abnormal_olfactory_system1.81484744
21MP0006072_abnormal_retinal_apoptosis1.80894848
22MP0000631_abnormal_neuroendocrine_gland1.72929067
23MP0002736_abnormal_nociception_after1.70222280
24MP0003937_abnormal_limbs/digits/tail_de1.64929321
25MP0005551_abnormal_eye_electrophysiolog1.63260392
26MP0003011_delayed_dark_adaptation1.60906299
27MP0001968_abnormal_touch/_nociception1.57901359
28MP0005253_abnormal_eye_physiology1.51348859
29MP0003119_abnormal_digestive_system1.49023725
30MP0002751_abnormal_autonomic_nervous1.48855008
31MP0010030_abnormal_orbit_morphology1.46132834
32MP0003195_calcinosis1.44767127
33MP0000049_abnormal_middle_ear1.43233324
34MP0009046_muscle_twitch1.37742423
35MP0001984_abnormal_olfaction1.32713081
36MP0001485_abnormal_pinna_reflex1.31750260
37MP0004142_abnormal_muscle_tone1.30998713
38MP0001486_abnormal_startle_reflex1.30897842
39MP0000566_synostosis1.27776512
40MP0002837_dystrophic_cardiac_calcinosis1.27099097
41MP0002160_abnormal_reproductive_system1.25415440
42MP0006276_abnormal_autonomic_nervous1.23818993
43MP0009745_abnormal_behavioral_response1.23310893
44MP0002272_abnormal_nervous_system1.23294940
45MP0009379_abnormal_foot_pigmentation1.23111894
46MP0004885_abnormal_endolymph1.20523687
47MP0010094_abnormal_chromosome_stability1.19840915
48MP0001286_abnormal_eye_development1.19529196
49MP0002233_abnormal_nose_morphology1.15391410
50MP0002234_abnormal_pharynx_morphology1.13416696
51MP0003718_maternal_effect1.12892951
52MP0008057_abnormal_DNA_replication1.12768379
53MP0005645_abnormal_hypothalamus_physiol1.11934790
54MP0002557_abnormal_social/conspecific_i1.10464652
55MP0005187_abnormal_penis_morphology1.09385899
56MP0003567_abnormal_fetal_cardiomyocyte1.09317072
57MP0000372_irregular_coat_pigmentation1.08913511
58MP0003755_abnormal_palate_morphology1.08320512
59MP0008995_early_reproductive_senescence1.06960568
60MP0005646_abnormal_pituitary_gland1.06778513
61MP0002653_abnormal_ependyma_morphology1.06030322
62MP0003693_abnormal_embryo_hatching1.05749906
63MP0003938_abnormal_ear_development1.05513617
64MP0002735_abnormal_chemical_nociception1.01740755
65MP0002734_abnormal_mechanical_nocicepti1.00637144
66MP0003861_abnormal_nervous_system0.99794777
67MP0002184_abnormal_innervation0.99206333
68MP0005391_vision/eye_phenotype0.98483084
69MP0004145_abnormal_muscle_electrophysio0.97754138
70MP0005195_abnormal_posterior_eye0.97069199
71MP0005386_behavior/neurological_phenoty0.97068570
72MP0004924_abnormal_behavior0.97068570
73MP0002752_abnormal_somatic_nervous0.96790300
74MP0002210_abnormal_sex_determination0.96222393
75MP0005423_abnormal_somatic_nervous0.95534935
76MP0005084_abnormal_gallbladder_morpholo0.95444210
77MP0002572_abnormal_emotion/affect_behav0.95122156
78MP0001324_abnormal_eye_pigmentation0.94369707
79MP0000427_abnormal_hair_cycle0.94177369
80MP0000955_abnormal_spinal_cord0.93043573
81MP0000647_abnormal_sebaceous_gland0.91272706
82MP0000026_abnormal_inner_ear0.90200967
83MP0001188_hyperpigmentation0.90005765
84MP0001986_abnormal_taste_sensitivity0.89451202
85MP0002697_abnormal_eye_size0.88851926
86MP0003646_muscle_fatigue0.87916540
87MP0001929_abnormal_gametogenesis0.87893006
88MP0002067_abnormal_sensory_capabilities0.87085096
89MP0005389_reproductive_system_phenotype0.86995314
90MP0005248_abnormal_Harderian_gland0.86937868
91MP0003941_abnormal_skin_development0.85972238
92MP0008872_abnormal_physiological_respon0.85795661
93MP0002095_abnormal_skin_pigmentation0.83101288
94MP0003698_abnormal_male_reproductive0.81282304
95MP0002282_abnormal_trachea_morphology0.81050355
96MP0003635_abnormal_synaptic_transmissio0.80742803
97MP0002064_seizures0.80400768
98MP0000653_abnormal_sex_gland0.80309306
99MP0005367_renal/urinary_system_phenotyp0.80061047
100MP0000516_abnormal_urinary_system0.80061047

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.59924949
2Pancreatic cysts (HP:0001737)3.54556953
3Pancreatic fibrosis (HP:0100732)3.47405984
4True hermaphroditism (HP:0010459)3.39592561
5Colon cancer (HP:0003003)3.32722326
6Abnormality of the labia minora (HP:0012880)3.25846923
7Molar tooth sign on MRI (HP:0002419)2.98852206
8Abnormality of midbrain morphology (HP:0002418)2.98852206
9Optic nerve hypoplasia (HP:0000609)2.97234159
10Nephronophthisis (HP:0000090)2.89009350
11Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.86969659
12Hyperventilation (HP:0002883)2.70382139
13Intestinal atresia (HP:0011100)2.61393605
14Medial flaring of the eyebrow (HP:0010747)2.51112041
15Chronic hepatic failure (HP:0100626)2.51079603
16Congenital stationary night blindness (HP:0007642)2.45765446
17Abnormality of the renal medulla (HP:0100957)2.40575472
18Anophthalmia (HP:0000528)2.37818624
19Acute necrotizing encephalopathy (HP:0006965)2.36883345
20Bile duct proliferation (HP:0001408)2.35335108
21Abnormal biliary tract physiology (HP:0012439)2.35335108
22Pendular nystagmus (HP:0012043)2.31168776
23Anencephaly (HP:0002323)2.25217759
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.22569735
25Oligodactyly (hands) (HP:0001180)2.22206232
26Progressive macrocephaly (HP:0004481)2.17785364
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.17584731
28Cystic liver disease (HP:0006706)2.16225372
29Absent septum pellucidum (HP:0001331)2.15929699
30Sclerocornea (HP:0000647)2.15899729
31Acute encephalopathy (HP:0006846)2.15535928
32Supernumerary spleens (HP:0009799)2.15299640
33Meckel diverticulum (HP:0002245)2.14769100
34Type II lissencephaly (HP:0007260)2.13762483
35Abnormality of the ileum (HP:0001549)2.13368714
36Genital tract atresia (HP:0001827)2.13034153
37Gait imbalance (HP:0002141)2.11726732
38Volvulus (HP:0002580)2.10174187
39Congenital primary aphakia (HP:0007707)2.08457346
40Vaginal atresia (HP:0000148)2.07717474
41Bilateral microphthalmos (HP:0007633)2.06130597
42Neoplasm of the adrenal cortex (HP:0100641)2.05965108
43Hypoplasia of the fovea (HP:0007750)2.00421438
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.00421438
45Methylmalonic acidemia (HP:0002912)1.99563609
46Broad-based gait (HP:0002136)1.99145362
47Abnormality of the septum pellucidum (HP:0007375)1.97731298
48Lissencephaly (HP:0001339)1.96772390
49Increased hepatocellular lipid droplets (HP:0006565)1.95536493
50Mitochondrial inheritance (HP:0001427)1.95311764
51Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.94709316
52Nephrogenic diabetes insipidus (HP:0009806)1.92821809
53Male pseudohermaphroditism (HP:0000037)1.92791529
54Stenosis of the external auditory canal (HP:0000402)1.92266253
55Lipid accumulation in hepatocytes (HP:0006561)1.90873592
56Abnormality of chromosome stability (HP:0003220)1.90684758
57Dandy-Walker malformation (HP:0001305)1.89914740
58Hepatoblastoma (HP:0002884)1.89843625
59Increased CSF lactate (HP:0002490)1.89774403
60Methylmalonic aciduria (HP:0012120)1.89737544
61Abnormality of the fovea (HP:0000493)1.85709290
62Ectopic kidney (HP:0000086)1.85517644
63Reticulocytopenia (HP:0001896)1.83858291
64Abnormal mitochondria in muscle tissue (HP:0008316)1.83190290
65Growth hormone deficiency (HP:0000824)1.82550526
66Decreased central vision (HP:0007663)1.81676091
67Midline defect of the nose (HP:0004122)1.81482025
68Postaxial hand polydactyly (HP:0001162)1.81465522
69Tubular atrophy (HP:0000092)1.80956220
70Glioma (HP:0009733)1.79389421
71Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78965723
72Inability to walk (HP:0002540)1.78492448
73Hyperglycinemia (HP:0002154)1.78434453
74Preaxial hand polydactyly (HP:0001177)1.78302853
75Drooling (HP:0002307)1.78109850
763-Methylglutaconic aciduria (HP:0003535)1.77638294
77Gastrointestinal atresia (HP:0002589)1.76781104
78Postaxial foot polydactyly (HP:0001830)1.76437160
79Triphalangeal thumb (HP:0001199)1.76165727
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.73644164
81Focal motor seizures (HP:0011153)1.72120282
82Small hand (HP:0200055)1.71917908
83Congenital, generalized hypertrichosis (HP:0004540)1.71681994
84Chromsome breakage (HP:0040012)1.70813592
85Abnormality of the renal cortex (HP:0011035)1.70242278
86Optic disc pallor (HP:0000543)1.69650893
87Optic nerve coloboma (HP:0000588)1.68594299
88Limb dystonia (HP:0002451)1.68552330
89Patellar aplasia (HP:0006443)1.68548073
90Congenital hepatic fibrosis (HP:0002612)1.67676345
91Narrow forehead (HP:0000341)1.67633730
92Labial hypoplasia (HP:0000066)1.67550177
93Bifid tongue (HP:0010297)1.66321147
94Keratoconus (HP:0000563)1.65065902
95Increased corneal curvature (HP:0100692)1.65065902
96Aqueductal stenosis (HP:0002410)1.64182266
97Retinal dysplasia (HP:0007973)1.63337397
98Maternal diabetes (HP:0009800)1.62592312
99Attenuation of retinal blood vessels (HP:0007843)1.62357957
100Abnormal drinking behavior (HP:0030082)1.59615889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.12293134
2FRK3.05764754
3CASK2.92426891
4ZAK2.72095670
5NUAK12.56579116
6TNIK2.38861987
7TRIM282.37188986
8CDC72.21533166
9MKNK22.18863968
10PNCK2.12181683
11MAP4K22.04420767
12MAPK132.02001336
13BMPR1B1.95614998
14DYRK21.94805862
15VRK21.87184568
16VRK11.83316910
17MAP3K41.81320212
18PLK31.74409842
19PLK41.71467697
20MKNK11.68706321
21TAF11.64724719
22SRPK11.62876664
23ADRBK21.57309754
24WEE11.56249255
25MARK11.52494538
26PLK21.43438679
27BCR1.37252617
28BRSK21.31829722
29GRK11.31208028
30ACVR1B1.29990387
31EPHB21.22965254
32TTK1.21522699
33TLK11.18515166
34BUB11.18038782
35CSNK1G21.17194921
36EPHA41.13777862
37MAP2K71.10781890
38INSRR1.09664618
39TIE11.06950943
40PINK11.05772520
41EIF2AK31.04966562
42CSNK1G11.04195165
43ERBB31.03720666
44DYRK30.99389530
45CDK190.98016327
46OXSR10.96605464
47PLK10.96108359
48WNK40.95161055
49CSNK1G30.94851331
50PRKCG0.90924489
51STK160.88547704
52TSSK60.88151479
53CSNK1A1L0.88017191
54MST40.86041055
55FGFR20.82944876
56PRKCE0.77802455
57PAK30.74413143
58MINK10.73250242
59STK390.73130677
60NEK10.73041025
61STK38L0.72673617
62ATR0.70686348
63LATS10.70328228
64BCKDK0.69938949
65TGFBR10.68198556
66NLK0.64180261
67ADRBK10.59514183
68PBK0.59495771
69ATM0.59261425
70MAP2K40.58587998
71CDK30.57347401
72NTRK20.56535256
73CHEK20.56421231
74MAP3K120.56331112
75OBSCN0.55660873
76PASK0.53892915
77NEK20.53523587
78EPHA30.53089531
79AURKB0.50732896
80PIK3CA0.49352440
81PHKG10.47490641
82PHKG20.47490641
83NME10.46025450
84CAMK2A0.44028487
85ERBB40.42901185
86STK110.41751053
87STK30.41004441
88PRKG10.40017858
89CSNK1E0.39969770
90CAMK1G0.39199268
91CSNK1A10.39025523
92DYRK1A0.38605995
93CAMKK20.38226082
94PRKACA0.37775541
95SGK2230.37594720
96SGK4940.37594720
97MAPK150.37513005
98SGK20.37291968
99BRSK10.36838975
100CSNK2A10.34143606

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.08933919
2Oxidative phosphorylation_Homo sapiens_hsa001902.81622396
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55668175
4Homologous recombination_Homo sapiens_hsa034402.40553026
5Fanconi anemia pathway_Homo sapiens_hsa034602.38459153
6Basal transcription factors_Homo sapiens_hsa030222.37364391
7Mismatch repair_Homo sapiens_hsa034302.33876206
8RNA polymerase_Homo sapiens_hsa030202.31960345
9Parkinsons disease_Homo sapiens_hsa050122.31678966
10Ribosome_Homo sapiens_hsa030102.15707073
11Non-homologous end-joining_Homo sapiens_hsa034502.13542058
12Phototransduction_Homo sapiens_hsa047442.04353665
13Propanoate metabolism_Homo sapiens_hsa006401.99039616
14Nicotine addiction_Homo sapiens_hsa050331.88621227
15Proteasome_Homo sapiens_hsa030501.87935631
16RNA degradation_Homo sapiens_hsa030181.87302802
17Huntingtons disease_Homo sapiens_hsa050161.80177791
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60612709
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.58615463
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57373965
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55891604
22Butanoate metabolism_Homo sapiens_hsa006501.54043013
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54000089
24Steroid biosynthesis_Homo sapiens_hsa001001.53924129
25Nitrogen metabolism_Homo sapiens_hsa009101.49081221
26DNA replication_Homo sapiens_hsa030301.48518146
27Alzheimers disease_Homo sapiens_hsa050101.46412787
28Nucleotide excision repair_Homo sapiens_hsa034201.45331995
29Cardiac muscle contraction_Homo sapiens_hsa042601.44372142
30Basal cell carcinoma_Homo sapiens_hsa052171.32378856
31RNA transport_Homo sapiens_hsa030131.32300732
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31203098
33Hedgehog signaling pathway_Homo sapiens_hsa043401.29218881
34Selenocompound metabolism_Homo sapiens_hsa004501.26936333
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25072150
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24550287
37Spliceosome_Homo sapiens_hsa030401.23282020
38Caffeine metabolism_Homo sapiens_hsa002321.15108953
39Linoleic acid metabolism_Homo sapiens_hsa005911.14014934
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13313770
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10246982
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08692758
43Taste transduction_Homo sapiens_hsa047421.08579875
44Tryptophan metabolism_Homo sapiens_hsa003801.08285796
45Base excision repair_Homo sapiens_hsa034101.06045961
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.05370754
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04220645
48Purine metabolism_Homo sapiens_hsa002300.98112396
49One carbon pool by folate_Homo sapiens_hsa006700.97680923
50Regulation of autophagy_Homo sapiens_hsa041400.96643110
51Olfactory transduction_Homo sapiens_hsa047400.96245433
52Cell cycle_Homo sapiens_hsa041100.95354313
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93724070
54Pyrimidine metabolism_Homo sapiens_hsa002400.93419706
55Ether lipid metabolism_Homo sapiens_hsa005650.92874963
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86362236
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85790171
58GABAergic synapse_Homo sapiens_hsa047270.85335765
59Morphine addiction_Homo sapiens_hsa050320.82385153
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81926051
61Peroxisome_Homo sapiens_hsa041460.81143146
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78802238
63Pyruvate metabolism_Homo sapiens_hsa006200.74972636
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73114284
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70676276
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68986664
67Hippo signaling pathway_Homo sapiens_hsa043900.68714509
68mRNA surveillance pathway_Homo sapiens_hsa030150.67657654
69Circadian entrainment_Homo sapiens_hsa047130.66222461
70Oocyte meiosis_Homo sapiens_hsa041140.66176656
71Serotonergic synapse_Homo sapiens_hsa047260.65867847
72TGF-beta signaling pathway_Homo sapiens_hsa043500.65658651
73Collecting duct acid secretion_Homo sapiens_hsa049660.65578611
74Vitamin digestion and absorption_Homo sapiens_hsa049770.65309804
75Glutamatergic synapse_Homo sapiens_hsa047240.64493589
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64434176
77Metabolic pathways_Homo sapiens_hsa011000.63800523
78Glutathione metabolism_Homo sapiens_hsa004800.63173176
79Dopaminergic synapse_Homo sapiens_hsa047280.61583804
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61356444
81Chemical carcinogenesis_Homo sapiens_hsa052040.61339056
82Insulin secretion_Homo sapiens_hsa049110.59511151
83Retinol metabolism_Homo sapiens_hsa008300.58717973
84Fatty acid elongation_Homo sapiens_hsa000620.56643847
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.55654255
86Wnt signaling pathway_Homo sapiens_hsa043100.54758957
87p53 signaling pathway_Homo sapiens_hsa041150.53805374
88Folate biosynthesis_Homo sapiens_hsa007900.50451117
89Axon guidance_Homo sapiens_hsa043600.48010662
90Tight junction_Homo sapiens_hsa045300.47905852
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.45450063
92Circadian rhythm_Homo sapiens_hsa047100.44779575
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44034829
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43285498
95Fatty acid degradation_Homo sapiens_hsa000710.43176096
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42890988
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40273071
98Alcoholism_Homo sapiens_hsa050340.39767781
99beta-Alanine metabolism_Homo sapiens_hsa004100.38601600
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36727593

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