ZNF618

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.58809482
2axonal fasciculation (GO:0007413)3.84783554
3axon extension involved in axon guidance (GO:0048846)3.69150244
4neuron projection extension involved in neuron projection guidance (GO:1902284)3.69150244
5neuron recognition (GO:0008038)3.60407174
6cell migration in hindbrain (GO:0021535)3.54537949
7camera-type eye morphogenesis (GO:0048593)3.54015121
8paraxial mesoderm development (GO:0048339)3.53501423
9substrate-independent telencephalic tangential migration (GO:0021826)3.42985979
10substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.42985979
11nucleobase catabolic process (GO:0046113)3.38543986
12spinal cord development (GO:0021510)3.26835414
13cell proliferation in forebrain (GO:0021846)3.25514030
14presynaptic membrane organization (GO:0097090)3.20555275
15positive regulation of gastrulation (GO:2000543)3.20468159
16body morphogenesis (GO:0010171)3.19667049
17presynaptic membrane assembly (GO:0097105)3.13909428
18retinal ganglion cell axon guidance (GO:0031290)3.11617012
19embryonic body morphogenesis (GO:0010172)3.10557352
20lateral sprouting from an epithelium (GO:0060601)3.09487627
21behavioral response to nicotine (GO:0035095)3.07264278
22dendritic spine morphogenesis (GO:0060997)3.05708023
23ganglion development (GO:0061548)3.05439914
24axon extension (GO:0048675)3.04018461
25neuronal stem cell maintenance (GO:0097150)3.02166149
26somite development (GO:0061053)3.00877969
27convergent extension (GO:0060026)2.97140054
28postsynaptic membrane organization (GO:0001941)2.93838207
29planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87771743
30establishment of tissue polarity (GO:0007164)2.85082359
31establishment of planar polarity (GO:0001736)2.85082359
32negative regulation of axon guidance (GO:1902668)2.83622842
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78904586
34artery development (GO:0060840)2.78592460
35limb bud formation (GO:0060174)2.73624955
36central nervous system projection neuron axonogenesis (GO:0021952)2.72968814
37cerebral cortex radially oriented cell migration (GO:0021799)2.72869406
38olfactory bulb development (GO:0021772)2.71428628
39lung-associated mesenchyme development (GO:0060484)2.68803632
40positive regulation of synapse assembly (GO:0051965)2.67727976
41regulation of axon guidance (GO:1902667)2.66813124
42limb development (GO:0060173)2.66652066
43appendage development (GO:0048736)2.66652066
44cranial nerve morphogenesis (GO:0021602)2.65892191
45kidney morphogenesis (GO:0060993)2.64369065
46negative regulation of axon extension involved in axon guidance (GO:0048843)2.63619990
47apical protein localization (GO:0045176)2.59257223
48neuron fate determination (GO:0048664)2.58486322
49neuron projection extension (GO:1990138)2.56273884
50outer ear morphogenesis (GO:0042473)2.55484247
51positive regulation of neuroblast proliferation (GO:0002052)2.53491217
52head development (GO:0060322)2.53282618
53nonmotile primary cilium assembly (GO:0035058)2.52777201
54regulation of axon extension involved in axon guidance (GO:0048841)2.52570116
55hindbrain development (GO:0030902)2.51294732
56dorsal/ventral axis specification (GO:0009950)2.48705594
57establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47479671
58lens fiber cell development (GO:0070307)2.46223370
59Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44316237
60dopaminergic neuron differentiation (GO:0071542)2.43406844
61lens morphogenesis in camera-type eye (GO:0002089)2.43227653
62midbrain development (GO:0030901)2.42685576
63spinal cord association neuron differentiation (GO:0021527)2.42193961
64regulation of establishment of planar polarity (GO:0090175)2.40808207
65urogenital system development (GO:0001655)2.40543265
66establishment of mitochondrion localization (GO:0051654)2.39789426
67neuron migration (GO:0001764)2.38291844
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37079032
69tongue development (GO:0043586)2.35640714
70regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32760552
71intraciliary transport (GO:0042073)2.30993972
72forebrain neuron differentiation (GO:0021879)2.30478009
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29742480
74dendrite morphogenesis (GO:0048813)2.28072864
75establishment of monopolar cell polarity (GO:0061162)2.27110440
76establishment or maintenance of monopolar cell polarity (GO:0061339)2.27110440
77establishment of nucleus localization (GO:0040023)2.26051725
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.25949680
79viral transcription (GO:0019083)2.24632249
80cochlea morphogenesis (GO:0090103)2.23883252
81G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.22295050
82microtubule severing (GO:0051013)2.22136308
83heterochromatin organization (GO:0070828)2.21824985
84negative chemotaxis (GO:0050919)2.21744575
85protein localization to synapse (GO:0035418)2.21525421
86pituitary gland development (GO:0021983)2.21132469
87non-canonical Wnt signaling pathway (GO:0035567)2.20906821
88forebrain development (GO:0030900)2.20517614
89neuron remodeling (GO:0016322)2.20042377
90regulation of acrosome reaction (GO:0060046)2.18867283
91translational termination (GO:0006415)2.18656497
92neural precursor cell proliferation (GO:0061351)2.17610286
93regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.17593553
94cell-cell junction maintenance (GO:0045217)2.17055239
95embryonic retina morphogenesis in camera-type eye (GO:0060059)2.16263576
96calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.15029110
97inner ear receptor cell development (GO:0060119)2.14960209
98pattern specification involved in kidney development (GO:0061004)2.14848307
99mesenchymal to epithelial transition (GO:0060231)2.14688115
100dendrite development (GO:0016358)2.14658964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.83696165
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.41258132
3EZH2_27304074_Chip-Seq_ESCs_Mouse3.01489163
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99582467
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.93735808
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.65848756
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54054463
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.48601682
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43282209
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.36984256
11PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.25921430
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22409605
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22409605
14RNF2_27304074_Chip-Seq_ESCs_Mouse2.18703999
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12779652
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02240632
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99182942
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97863939
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.92997029
20RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89630335
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88534627
22RNF2_27304074_Chip-Seq_NSC_Mouse1.86876599
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83539473
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77973781
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74031568
26TP53_20018659_ChIP-ChIP_R1E_Mouse1.72817696
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71981267
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70851763
29RING1B_27294783_Chip-Seq_ESCs_Mouse1.65809453
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65765980
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63470215
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.63147760
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59832317
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.57190708
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.56128936
36REST_21632747_ChIP-Seq_MESCs_Mouse1.55964753
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55779456
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53926815
39OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.53089362
40ISL1_27105846_Chip-Seq_CPCs_Mouse1.45360856
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42125160
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.40017276
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37732561
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37732561
45GBX2_23144817_ChIP-Seq_PC3_Human1.36585998
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.34427006
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32965880
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.31366695
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31045124
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30307998
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28504728
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25389085
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23838014
54STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22078312
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21699587
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21246459
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18866381
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18136293
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.16498279
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14583412
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14529774
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14523181
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14373548
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13227656
65ZNF274_21170338_ChIP-Seq_K562_Hela1.12667847
66TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11916944
67FUS_26573619_Chip-Seq_HEK293_Human1.11875369
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11636209
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11610907
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08678165
71DROSHA_22980978_ChIP-Seq_HELA_Human1.08634629
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07381481
73IRF1_19129219_ChIP-ChIP_H3396_Human1.06589067
74EWS_26573619_Chip-Seq_HEK293_Human1.06042965
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05598357
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05228037
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05203134
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02193162
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01190614
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97719547
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.96058154
82TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95828725
83P300_19829295_ChIP-Seq_ESCs_Human0.94951796
84SOX9_26525672_Chip-Seq_HEART_Mouse0.94664671
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94563594
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93508511
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93106249
88* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93089742
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.92371703
90PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89019495
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89001310
92* SMAD3_21741376_ChIP-Seq_EPCs_Human0.88930118
93FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88719438
94VDR_22108803_ChIP-Seq_LS180_Human0.87757314
95CTCF_27219007_Chip-Seq_Bcells_Human0.86509129
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85723601
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.85680813
98* AR_19668381_ChIP-Seq_PC3_Human0.85544134
99* SMAD4_21799915_ChIP-Seq_A2780_Human0.85137695
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85119770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.63439264
2MP0010030_abnormal_orbit_morphology3.33731984
3MP0000778_abnormal_nervous_system2.73197914
4MP0000566_synostosis2.51682939
5MP0009379_abnormal_foot_pigmentation2.42279933
6MP0003122_maternal_imprinting2.26560661
7MP0000049_abnormal_middle_ear2.21337979
8MP0008789_abnormal_olfactory_epithelium2.11766308
9MP0005499_abnormal_olfactory_system2.05090449
10MP0005394_taste/olfaction_phenotype2.05090449
11MP0001293_anophthalmia2.03742765
12MP0003121_genomic_imprinting2.00433424
13MP0003283_abnormal_digestive_organ1.95697365
14MP0003890_abnormal_embryonic-extraembry1.90625046
15MP0003787_abnormal_imprinting1.82625739
16MP0002938_white_spotting1.76962647
17MP0004133_heterotaxia1.75238846
18MP0003942_abnormal_urinary_system1.72700394
19MP0003937_abnormal_limbs/digits/tail_de1.68784504
20MP0009053_abnormal_anal_canal1.68365962
21MP0000537_abnormal_urethra_morphology1.68306138
22MP0002697_abnormal_eye_size1.64235544
23MP0001286_abnormal_eye_development1.59948593
24MP0003119_abnormal_digestive_system1.56887101
25MP0002653_abnormal_ependyma_morphology1.56725791
26MP0003385_abnormal_body_wall1.55229947
27MP0003136_yellow_coat_color1.54406604
28MP0002233_abnormal_nose_morphology1.54200792
29MP0001299_abnormal_eye_distance/1.53958776
30MP0003861_abnormal_nervous_system1.53787085
31MP0003938_abnormal_ear_development1.53275136
32MP0000631_abnormal_neuroendocrine_gland1.52908497
33MP0003755_abnormal_palate_morphology1.52675709
34MP0004859_abnormal_synaptic_plasticity1.50991467
35MP0002249_abnormal_larynx_morphology1.50210649
36MP0000534_abnormal_ureter_morphology1.50166733
37MP0003123_paternal_imprinting1.49448716
38MP0008877_abnormal_DNA_methylation1.47220950
39MP0000955_abnormal_spinal_cord1.41887998
40MP0005257_abnormal_intraocular_pressure1.39057494
41MP0006276_abnormal_autonomic_nervous1.37122141
42MP0000428_abnormal_craniofacial_morphol1.34992838
43MP0002184_abnormal_innervation1.34575323
44MP0002116_abnormal_craniofacial_bone1.33088667
45MP0001529_abnormal_vocalization1.30262265
46MP0005409_darkened_coat_color1.29692117
47MP0003880_abnormal_central_pattern1.29524593
48MP0002092_abnormal_eye_morphology1.29132186
49MP0005423_abnormal_somatic_nervous1.28383938
50MP0002822_catalepsy1.26688734
51MP0009250_abnormal_appendicular_skeleto1.26537311
52MP0002102_abnormal_ear_morphology1.25616372
53MP0003935_abnormal_craniofacial_develop1.24222229
54MP0002152_abnormal_brain_morphology1.20088854
55MP0001188_hyperpigmentation1.18442846
56MP0002234_abnormal_pharynx_morphology1.18294273
57MP0010368_abnormal_lymphatic_system1.18175276
58MP0005503_abnormal_tendon_morphology1.14477847
59MP0005248_abnormal_Harderian_gland1.10656083
60MP0002751_abnormal_autonomic_nervous1.09574065
61MP0000026_abnormal_inner_ear1.08394595
62MP0002752_abnormal_somatic_nervous1.07157199
63MP0004142_abnormal_muscle_tone1.06718951
64MP0002557_abnormal_social/conspecific_i1.03339932
65MP0002882_abnormal_neuron_morphology1.02013504
66MP0004885_abnormal_endolymph1.01195689
67MP0002081_perinatal_lethality0.98776395
68MP0002932_abnormal_joint_morphology0.97909242
69MP0002084_abnormal_developmental_patter0.97857536
70MP0002734_abnormal_mechanical_nocicepti0.97014043
71MP0002085_abnormal_embryonic_tissue0.95135140
72MP0002638_abnormal_pupillary_reflex0.94406158
73MP0003567_abnormal_fetal_cardiomyocyte0.93328948
74MP0000579_abnormal_nail_morphology0.92103548
75MP0005391_vision/eye_phenotype0.91565321
76MP0005195_abnormal_posterior_eye0.91084052
77MP0000432_abnormal_head_morphology0.90740568
78MP0003315_abnormal_perineum_morphology0.90732503
79MP0000762_abnormal_tongue_morphology0.88740104
80MP0005187_abnormal_penis_morphology0.87686677
81MP0002063_abnormal_learning/memory/cond0.87056733
82MP0003635_abnormal_synaptic_transmissio0.85735227
83MP0005377_hearing/vestibular/ear_phenot0.85563702
84MP0003878_abnormal_ear_physiology0.85563702
85MP0004811_abnormal_neuron_physiology0.84782844
86MP0001984_abnormal_olfaction0.83322110
87MP0002111_abnormal_tail_morphology0.82881790
88MP0002177_abnormal_outer_ear0.82216626
89MP0004270_analgesia0.81683597
90MP0005197_abnormal_uvea_morphology0.79345272
91MP0003115_abnormal_respiratory_system0.77582655
92MP0002572_abnormal_emotion/affect_behav0.77358519
93MP0002114_abnormal_axial_skeleton0.77243758
94MP0001879_abnormal_lymphatic_vessel0.76967573
95MP0005508_abnormal_skeleton_morphology0.76111835
96MP0001346_abnormal_lacrimal_gland0.75135071
97MP0002109_abnormal_limb_morphology0.73564042
98MP0000462_abnormal_digestive_system0.71558965
99MP0003718_maternal_effect0.69247839
100MP0009384_cardiac_valve_regurgitation0.68743138

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.62985270
2Short 4th metacarpal (HP:0010044)3.38353032
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.38353032
4Abnormality of the 4th metacarpal (HP:0010012)2.88504017
5Hepatoblastoma (HP:0002884)2.76331403
6High anterior hairline (HP:0009890)2.66771044
7Abnormality of the labia minora (HP:0012880)2.40265466
8Optic nerve hypoplasia (HP:0000609)2.34254798
9Vitreoretinal degeneration (HP:0000655)2.31347685
10Abnormal number of incisors (HP:0011064)2.26171138
11Absent septum pellucidum (HP:0001331)2.25298808
12Cutaneous finger syndactyly (HP:0010554)2.23303824
13Reticulocytopenia (HP:0001896)2.19093508
14Anophthalmia (HP:0000528)2.18970040
15Shawl scrotum (HP:0000049)2.12658474
16Anterior segment dysgenesis (HP:0007700)2.11091509
17Myokymia (HP:0002411)2.11005719
18Shallow orbits (HP:0000586)2.10982367
19Maternal diabetes (HP:0009800)2.10874226
20Cutaneous syndactyly (HP:0012725)2.09828534
21Cortical dysplasia (HP:0002539)2.07795197
22Oligodactyly (HP:0012165)2.06363222
23Abnormality of abdominal situs (HP:0011620)2.05082573
24Abdominal situs inversus (HP:0003363)2.05082573
25Coronal craniosynostosis (HP:0004440)2.04016662
26Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03008613
27Rib fusion (HP:0000902)2.00930549
28Broad thumb (HP:0011304)1.99932661
29Oligodactyly (hands) (HP:0001180)1.96913693
30Abnormality of the aortic arch (HP:0012303)1.96693190
31Renal dysplasia (HP:0000110)1.95275198
32Partial duplication of the phalanx of hand (HP:0009999)1.94260161
33Turricephaly (HP:0000262)1.93257346
34Abnormality of the septum pellucidum (HP:0007375)1.91652069
35Partial duplication of thumb phalanx (HP:0009944)1.90138906
36Trigonocephaly (HP:0000243)1.89189946
37Broad phalanges of the hand (HP:0009768)1.88103437
38Broad finger (HP:0001500)1.87456616
39Abnormality of the phalanges of the hallux (HP:0010057)1.85019748
40Patellar aplasia (HP:0006443)1.84746041
41Growth hormone deficiency (HP:0000824)1.83932503
42Ectopic kidney (HP:0000086)1.83237086
43Abnormality of the diencephalon (HP:0010662)1.81365196
44Colon cancer (HP:0003003)1.81080159
45Anencephaly (HP:0002323)1.80941291
46Broad metatarsal (HP:0001783)1.79550359
47Morphological abnormality of the middle ear (HP:0008609)1.79331776
48Broad long bones (HP:0005622)1.79020342
49Midline defect of the nose (HP:0004122)1.78811100
50Broad phalanx (HP:0006009)1.77867602
51Nephronophthisis (HP:0000090)1.77859579
52Lissencephaly (HP:0001339)1.77203827
53Pancreatic fibrosis (HP:0100732)1.76126083
54Abnormal hair whorl (HP:0010721)1.73989940
55Neonatal short-limb short stature (HP:0008921)1.73820254
56Drooling (HP:0002307)1.73156635
57Wide anterior fontanel (HP:0000260)1.72593573
58Aplasia/Hypoplasia of the patella (HP:0006498)1.71377343
59Hypoplastic ischia (HP:0003175)1.71126690
60Enlarged penis (HP:0000040)1.70463411
61Preaxial foot polydactyly (HP:0001841)1.70000154
62Partial agenesis of the corpus callosum (HP:0001338)1.69365912
63Micropenis (HP:0000054)1.67777440
64Renovascular hypertension (HP:0100817)1.66916099
65Abnormality of the ischium (HP:0003174)1.64702170
66Intestinal atresia (HP:0011100)1.63816181
67Fibular hypoplasia (HP:0003038)1.61891610
68Renal hypoplasia (HP:0000089)1.61507171
69Holoprosencephaly (HP:0001360)1.61133872
70Duplication of thumb phalanx (HP:0009942)1.58239626
71Facial hemangioma (HP:0000329)1.57844606
72Esophageal atresia (HP:0002032)1.57716786
73Preaxial hand polydactyly (HP:0001177)1.57118934
74Sclerocornea (HP:0000647)1.57067139
75Molar tooth sign on MRI (HP:0002419)1.55937971
76Abnormality of midbrain morphology (HP:0002418)1.55937971
77Hypoplastic pelvis (HP:0008839)1.55400680
78Osteomalacia (HP:0002749)1.53918526
79Abnormality of the intervertebral disk (HP:0005108)1.53535402
80Abnormality of the antihelix (HP:0009738)1.53367530
81Abnormality of the incisor (HP:0000676)1.53219791
82Omphalocele (HP:0001539)1.52632137
83Bilateral microphthalmos (HP:0007633)1.52592140
84Myelomeningocele (HP:0002475)1.52218091
85Down-sloping shoulders (HP:0200021)1.50902875
86Abnormality of dentin (HP:0010299)1.50764632
87Aqueductal stenosis (HP:0002410)1.50581311
88Labial hypoplasia (HP:0000066)1.50179834
89Broad hallux (HP:0010055)1.50076573
90Obsessive-compulsive behavior (HP:0000722)1.49344300
91Pachygyria (HP:0001302)1.49028140
92Abnormality of the phalanges of the 2nd finger (HP:0009541)1.48367042
93Sleep apnea (HP:0010535)1.48091725
94Vaginal atresia (HP:0000148)1.47802520
95Hemivertebrae (HP:0002937)1.47766282
96Genital tract atresia (HP:0001827)1.47556528
97Supernumerary spleens (HP:0009799)1.47370444
98Abnormality of the renal medulla (HP:0100957)1.47331298
99Hypoplasia of the ulna (HP:0003022)1.46985037
100Pendular nystagmus (HP:0012043)1.46444020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.93418402
2MARK13.33164472
3PNCK3.21160081
4TNIK2.79400431
5CASK2.65347733
6DYRK22.29368669
7NTRK22.21770852
8CAMK1G2.19195993
9TYRO32.03610879
10NTRK11.81974188
11CAMK1D1.76558058
12MAP3K41.72644497
13MAP3K91.63744177
14CDC71.60968465
15TIE11.58218325
16DYRK31.57169526
17WNK31.55141397
18MKNK21.39613868
19NTRK31.39393147
20NEK21.33717982
21MAP2K71.32169958
22MKNK11.31032012
23MAP3K101.29664534
24ICK1.23677143
25FGFR21.19194187
26EPHA41.15727720
27LATS21.12853108
28BCR1.11494144
29DYRK1B1.08641335
30WNK41.07310679
31KSR11.06311616
32TAF11.06120222
33TRIM281.00852401
34LATS10.95691377
35RPS6KA20.93779005
36PRKD30.93768651
37MARK20.92847872
38MAPK130.88705557
39MTOR0.87609707
40CDK120.86588991
41PTK20.86163832
42MINK10.85510541
43SGK4940.84184175
44SGK2230.84184175
45CDK190.84127166
46WEE10.83570438
47CSNK1G20.83186905
48AURKA0.79907837
49PRKCG0.78141387
50UHMK10.77987683
51BRD40.77894215
52STK30.75784252
53DYRK1A0.74261086
54MAPK150.74153369
55STK160.72295002
56SGK20.71782849
57TGFBR10.70758875
58TTK0.70249302
59DMPK0.69339687
60PLK40.69139569
61CHEK20.68791670
62BRAF0.68650146
63BMPR1B0.68097644
64PLK10.67600891
65EEF2K0.66914707
66ERBB20.66740239
67CDK11A0.66555062
68SIK20.66553505
69CSNK1E0.65624001
70PDGFRA0.65368434
71STK110.64608971
72CSNK1G10.64538259
73CDK150.63505110
74CDK50.60186398
75RPS6KA60.59636679
76CDK180.59200745
77NME10.57999428
78MAP2K40.57733457
79DDR20.57213646
80CHEK10.57053913
81RPS6KL10.56780827
82RPS6KC10.56780827
83PAK20.56202140
84CDK140.55995269
85PLK30.55398751
86MET0.53469079
87ATR0.53466928
88NUAK10.53326205
89CSNK1G30.53183971
90PLK20.52352302
91CDK10.52155480
92AURKB0.51457702
93CSNK1A1L0.50046540
94CDK20.50029746
95MOS0.49968964
96ATM0.47315319
97PRKCZ0.47123144
98PAK30.46562085
99GSK3B0.46205763
100PRKDC0.44657367

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.19859786
2Hedgehog signaling pathway_Homo sapiens_hsa043402.82982859
3Axon guidance_Homo sapiens_hsa043602.52657414
4Hippo signaling pathway_Homo sapiens_hsa043902.27312512
5Ribosome_Homo sapiens_hsa030102.25648959
6Notch signaling pathway_Homo sapiens_hsa043301.96195618
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.94642957
8Nicotine addiction_Homo sapiens_hsa050331.93905472
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.86985409
10Wnt signaling pathway_Homo sapiens_hsa043101.73539867
11Cocaine addiction_Homo sapiens_hsa050301.51758926
12Melanogenesis_Homo sapiens_hsa049161.50350063
13Adherens junction_Homo sapiens_hsa045201.49385685
14Cardiac muscle contraction_Homo sapiens_hsa042601.49312922
15ECM-receptor interaction_Homo sapiens_hsa045121.48239749
16Fanconi anemia pathway_Homo sapiens_hsa034601.45342341
17Gap junction_Homo sapiens_hsa045401.45289428
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42862272
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41047890
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38819336
21Steroid biosynthesis_Homo sapiens_hsa001001.35256130
22Phototransduction_Homo sapiens_hsa047441.30266885
23Basal transcription factors_Homo sapiens_hsa030221.27089971
24Cell cycle_Homo sapiens_hsa041101.21681550
25TGF-beta signaling pathway_Homo sapiens_hsa043501.19129818
26Lysine degradation_Homo sapiens_hsa003101.18108228
27Glutamatergic synapse_Homo sapiens_hsa047241.16275940
28MicroRNAs in cancer_Homo sapiens_hsa052061.08869287
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06443785
30Tight junction_Homo sapiens_hsa045301.06031403
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04127568
32Dopaminergic synapse_Homo sapiens_hsa047281.03578523
33Dilated cardiomyopathy_Homo sapiens_hsa054141.03073318
34Morphine addiction_Homo sapiens_hsa050321.02957582
35Circadian entrainment_Homo sapiens_hsa047131.02545317
36Protein digestion and absorption_Homo sapiens_hsa049741.01054562
37Cholinergic synapse_Homo sapiens_hsa047250.97589110
38GABAergic synapse_Homo sapiens_hsa047270.96687675
39Insulin secretion_Homo sapiens_hsa049110.96602625
40Huntingtons disease_Homo sapiens_hsa050160.95781520
41Dorso-ventral axis formation_Homo sapiens_hsa043200.94249093
42Ovarian steroidogenesis_Homo sapiens_hsa049130.93366153
43Pathways in cancer_Homo sapiens_hsa052000.92320139
44RNA degradation_Homo sapiens_hsa030180.91549053
45Long-term depression_Homo sapiens_hsa047300.90422895
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89022731
47Serotonergic synapse_Homo sapiens_hsa047260.86557183
48Colorectal cancer_Homo sapiens_hsa052100.86458643
49mRNA surveillance pathway_Homo sapiens_hsa030150.85256045
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85102574
51Melanoma_Homo sapiens_hsa052180.83099130
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82943207
53Protein export_Homo sapiens_hsa030600.82354557
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81513814
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80286035
56Focal adhesion_Homo sapiens_hsa045100.80087543
57Parkinsons disease_Homo sapiens_hsa050120.78699579
58Sulfur relay system_Homo sapiens_hsa041220.77835114
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77254058
60RNA polymerase_Homo sapiens_hsa030200.76263657
61Base excision repair_Homo sapiens_hsa034100.74336145
62Spliceosome_Homo sapiens_hsa030400.72453112
63RNA transport_Homo sapiens_hsa030130.72283911
64Endometrial cancer_Homo sapiens_hsa052130.71042716
65Homologous recombination_Homo sapiens_hsa034400.70808024
66Rap1 signaling pathway_Homo sapiens_hsa040150.70149713
67Mismatch repair_Homo sapiens_hsa034300.70120619
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69149920
69ErbB signaling pathway_Homo sapiens_hsa040120.68735704
70Taste transduction_Homo sapiens_hsa047420.67855544
71cAMP signaling pathway_Homo sapiens_hsa040240.67097774
72Oocyte meiosis_Homo sapiens_hsa041140.65964842
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63924307
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63900909
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.63564137
76Ras signaling pathway_Homo sapiens_hsa040140.63453343
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62469603
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62362480
79Oxidative phosphorylation_Homo sapiens_hsa001900.60435051
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59986019
81Oxytocin signaling pathway_Homo sapiens_hsa049210.58936099
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.58812778
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58580388
84Non-homologous end-joining_Homo sapiens_hsa034500.58288768
85Selenocompound metabolism_Homo sapiens_hsa004500.56321878
86Thyroid cancer_Homo sapiens_hsa052160.52680139
87Thyroid hormone synthesis_Homo sapiens_hsa049180.52221558
88Nucleotide excision repair_Homo sapiens_hsa034200.52063921
89Proteoglycans in cancer_Homo sapiens_hsa052050.51840526
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50638484
91p53 signaling pathway_Homo sapiens_hsa041150.50239487
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.49209104
93Olfactory transduction_Homo sapiens_hsa047400.48603719
94Alzheimers disease_Homo sapiens_hsa050100.47607953
95Butanoate metabolism_Homo sapiens_hsa006500.47555764
96Amphetamine addiction_Homo sapiens_hsa050310.45603151
97Folate biosynthesis_Homo sapiens_hsa007900.44998163
98Gastric acid secretion_Homo sapiens_hsa049710.44777314
99Prostate cancer_Homo sapiens_hsa052150.43800262
100Alcoholism_Homo sapiens_hsa050340.43196794

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