ZNF615

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.22937339
2replication fork processing (GO:0031297)4.46302070
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.27674202
4negative regulation of translation, ncRNA-mediated (GO:0040033)4.27674202
5regulation of translation, ncRNA-mediated (GO:0045974)4.27674202
6artery development (GO:0060840)4.26506750
7intraciliary transport (GO:0042073)4.20705441
8cerebral cortex radially oriented cell migration (GO:0021799)4.11129160
9synapsis (GO:0007129)4.05634501
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95897365
11regulation of meiosis I (GO:0060631)3.82801139
12neural tube formation (GO:0001841)3.64407906
13otic vesicle formation (GO:0030916)3.58847310
14nonmotile primary cilium assembly (GO:0035058)3.58433773
15negative regulation of astrocyte differentiation (GO:0048712)3.55031260
16somite development (GO:0061053)3.53603146
17regulation of DNA endoreduplication (GO:0032875)3.53268084
18limb bud formation (GO:0060174)3.25374426
19presynaptic membrane assembly (GO:0097105)3.25372893
20piRNA metabolic process (GO:0034587)3.23924744
21regulation of non-canonical Wnt signaling pathway (GO:2000050)3.18464916
22photoreceptor cell maintenance (GO:0045494)3.16839433
23behavioral response to nicotine (GO:0035095)3.16367676
24epithelial cilium movement (GO:0003351)3.12061645
25kinetochore organization (GO:0051383)3.09729670
26regulation of heat generation (GO:0031650)3.01874907
27regulation of cilium movement (GO:0003352)3.00327088
28tongue development (GO:0043586)2.98477678
29centriole replication (GO:0007099)2.98272736
30transmission of nerve impulse (GO:0019226)2.97913258
31regulation of male gonad development (GO:2000018)2.97299533
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94926452
33spermatid nucleus differentiation (GO:0007289)2.93644821
34cilium organization (GO:0044782)2.92813944
35cilium morphogenesis (GO:0060271)2.92400218
36negative regulation of DNA recombination (GO:0045910)2.91659847
37cilium assembly (GO:0042384)2.91556838
38reciprocal DNA recombination (GO:0035825)2.90481702
39reciprocal meiotic recombination (GO:0007131)2.90481702
40retinal cone cell development (GO:0046549)2.89315415
41indolalkylamine metabolic process (GO:0006586)2.86380512
42regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85956257
43DNA ligation (GO:0006266)2.84661638
44olfactory bulb development (GO:0021772)2.83554479
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.81440146
46inner ear receptor stereocilium organization (GO:0060122)2.80401130
47presynaptic membrane organization (GO:0097090)2.77277613
48DNA methylation involved in gamete generation (GO:0043046)2.76377278
49mitotic sister chromatid cohesion (GO:0007064)2.74158271
50positive regulation of male gonad development (GO:2000020)2.73505261
51regulation of telomere maintenance (GO:0032204)2.72741449
52prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.72314162
53meiotic chromosome segregation (GO:0045132)2.71687600
54male meiosis (GO:0007140)2.70582361
55interkinetic nuclear migration (GO:0022027)2.70022944
56neuron fate determination (GO:0048664)2.69867280
57cilium movement (GO:0003341)2.69274430
58establishment of protein localization to Golgi (GO:0072600)2.65101116
59regulation of timing of cell differentiation (GO:0048505)2.64908831
60resolution of meiotic recombination intermediates (GO:0000712)2.64692085
61cellular response to sterol (GO:0036315)2.64665195
62keratinocyte development (GO:0003334)2.64342664
63cerebral cortex cell migration (GO:0021795)2.63481009
64detection of light stimulus involved in visual perception (GO:0050908)2.62785819
65detection of light stimulus involved in sensory perception (GO:0050962)2.62785819
66histone H2A acetylation (GO:0043968)2.62443066
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62143196
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61102980
69monoubiquitinated protein deubiquitination (GO:0035520)2.60094215
70microtubule anchoring (GO:0034453)2.57478942
71radial glial cell differentiation (GO:0060019)2.57427914
72DNA integration (GO:0015074)2.55760364
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.55541503
74mechanosensory behavior (GO:0007638)2.55366726
75cell proliferation in forebrain (GO:0021846)2.52860168
76response to pheromone (GO:0019236)2.52303486
77central nervous system projection neuron axonogenesis (GO:0021952)2.51859898
78histone H3-K9 methylation (GO:0051567)2.50213273
79regulation of glucokinase activity (GO:0033131)2.48942947
80regulation of hexokinase activity (GO:1903299)2.48942947
81recombinational repair (GO:0000725)2.48451000
82embryonic digestive tract morphogenesis (GO:0048557)2.47232973
83prenylation (GO:0097354)2.46985874
84protein prenylation (GO:0018342)2.46985874
85sex differentiation (GO:0007548)2.46573725
86double-strand break repair via homologous recombination (GO:0000724)2.46241222
87striatum development (GO:0021756)2.45168968
88axoneme assembly (GO:0035082)2.45040404
89regulation of development, heterochronic (GO:0040034)2.44333033
90C4-dicarboxylate transport (GO:0015740)2.42889856
91DNA catabolic process, exonucleolytic (GO:0000738)2.42572967
92tryptophan catabolic process (GO:0006569)2.40285757
93indole-containing compound catabolic process (GO:0042436)2.40285757
94indolalkylamine catabolic process (GO:0046218)2.40285757
95protein K6-linked ubiquitination (GO:0085020)2.39492164
96pre-miRNA processing (GO:0031054)2.39094866
97negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.38384829
98chromosome organization involved in meiosis (GO:0070192)2.38162934
99cellular response to cholesterol (GO:0071397)2.37638351
100smoothened signaling pathway (GO:0007224)2.37429253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.30901115
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.08874384
3* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.02577501
4IGF1R_20145208_ChIP-Seq_DFB_Human2.97829557
5ZNF274_21170338_ChIP-Seq_K562_Hela2.94708160
6GBX2_23144817_ChIP-Seq_PC3_Human2.93796774
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77695667
8TAF15_26573619_Chip-Seq_HEK293_Human2.63225526
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62795561
10FUS_26573619_Chip-Seq_HEK293_Human2.61401613
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61116680
12EZH2_22144423_ChIP-Seq_EOC_Human2.55404547
13VDR_22108803_ChIP-Seq_LS180_Human2.54799467
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41252328
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.24609020
16P300_19829295_ChIP-Seq_ESCs_Human2.21757506
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16731044
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12752999
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.10648385
20EWS_26573619_Chip-Seq_HEK293_Human2.03702098
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88444915
22ER_23166858_ChIP-Seq_MCF-7_Human1.86705752
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.86414984
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85446873
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78789260
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.78506602
27SMAD4_21799915_ChIP-Seq_A2780_Human1.76288164
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70016320
29AR_25329375_ChIP-Seq_VCAP_Human1.64951556
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.64316230
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62467058
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61262340
33STAT3_23295773_ChIP-Seq_U87_Human1.59235089
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.59041507
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58115358
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58115358
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57862447
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57386411
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55050658
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53870805
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51098556
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47983086
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46281849
44IRF1_19129219_ChIP-ChIP_H3396_Human1.45636350
45BCAT_22108803_ChIP-Seq_LS180_Human1.44747488
46TCF4_23295773_ChIP-Seq_U87_Human1.44418187
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.43213789
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38288646
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.37980641
50CBP_20019798_ChIP-Seq_JUKART_Human1.37370951
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37370951
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37152036
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35992740
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.35394012
55* RUNX2_22187159_ChIP-Seq_PCA_Human1.34724160
56RNF2_27304074_Chip-Seq_NSC_Mouse1.34427446
57* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33658894
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32700173
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32540856
60AR_21572438_ChIP-Seq_LNCaP_Human1.30216738
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27989604
62TCF4_22108803_ChIP-Seq_LS180_Human1.23320526
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.22701075
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22408424
65ELK1_19687146_ChIP-ChIP_HELA_Human1.22133520
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21993957
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21898891
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21567175
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21542526
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.17440510
71P53_22387025_ChIP-Seq_ESCs_Mouse1.15970785
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.15903744
73TP53_22573176_ChIP-Seq_HFKS_Human1.10785694
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10493050
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.10195669
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.10121940
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.09468996
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.08612598
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08067654
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07335857
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05853775
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04261999
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04197282
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.04102699
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03865675
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03620887
87NANOG_19829295_ChIP-Seq_ESCs_Human1.03256043
88SOX2_19829295_ChIP-Seq_ESCs_Human1.03256043
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02938550
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.02485229
91P300_18555785_Chip-Seq_ESCs_Mouse1.02345360
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00942509
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.00193488
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.00044794
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99263696
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.99237390
97KDM2B_26808549_Chip-Seq_REH_Human0.98795805
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98791811
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98537165
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98494569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.63239073
2MP0008877_abnormal_DNA_methylation2.90645124
3MP0000569_abnormal_digit_pigmentation2.37492958
4MP0003787_abnormal_imprinting2.28291579
5MP0008058_abnormal_DNA_repair2.25714184
6MP0004145_abnormal_muscle_electrophysio2.22068425
7MP0000566_synostosis2.15574197
8MP0005248_abnormal_Harderian_gland2.13868224
9MP0000537_abnormal_urethra_morphology2.13163892
10MP0002102_abnormal_ear_morphology2.05444553
11MP0002234_abnormal_pharynx_morphology2.02447567
12MP0002736_abnormal_nociception_after2.01735420
13MP0003121_genomic_imprinting2.00439238
14MP0005551_abnormal_eye_electrophysiolog2.00289955
15MP0002009_preneoplasia1.96273058
16MP0008789_abnormal_olfactory_epithelium1.90583484
17MP0010030_abnormal_orbit_morphology1.85483868
18MP0005187_abnormal_penis_morphology1.80627550
19MP0003646_muscle_fatigue1.79590505
20MP0000631_abnormal_neuroendocrine_gland1.79069240
21MP0001968_abnormal_touch/_nociception1.75744706
22MP0003122_maternal_imprinting1.74098678
23MP0002938_white_spotting1.71996321
24MP0004133_heterotaxia1.70655452
25MP0008057_abnormal_DNA_replication1.63943851
26MP0003315_abnormal_perineum_morphology1.63461579
27MP0006072_abnormal_retinal_apoptosis1.62623075
28MP0005645_abnormal_hypothalamus_physiol1.62250761
29MP0005646_abnormal_pituitary_gland1.61333282
30MP0000383_abnormal_hair_follicle1.54233393
31MP0003880_abnormal_central_pattern1.51748679
32MP0000427_abnormal_hair_cycle1.50663485
33MP0005394_taste/olfaction_phenotype1.48764911
34MP0005499_abnormal_olfactory_system1.48764911
35MP0003937_abnormal_limbs/digits/tail_de1.47555079
36MP0000516_abnormal_urinary_system1.47117154
37MP0005367_renal/urinary_system_phenotyp1.47117154
38MP0005253_abnormal_eye_physiology1.46347718
39MP0003195_calcinosis1.40127296
40MP0000778_abnormal_nervous_system1.38862297
41MP0004043_abnormal_pH_regulation1.34563861
42MP0003938_abnormal_ear_development1.33716072
43MP0002233_abnormal_nose_morphology1.30894726
44MP0003136_yellow_coat_color1.30695719
45MP0009046_muscle_twitch1.29584151
46MP0006276_abnormal_autonomic_nervous1.28928289
47MP0004885_abnormal_endolymph1.28108939
48MP0001486_abnormal_startle_reflex1.27246201
49MP0003567_abnormal_fetal_cardiomyocyte1.26746086
50MP0002735_abnormal_chemical_nociception1.25472712
51MP0000372_irregular_coat_pigmentation1.23884434
52MP0001485_abnormal_pinna_reflex1.21365769
53MP0001501_abnormal_sleep_pattern1.19163396
54MP0001293_anophthalmia1.16411767
55MP0002653_abnormal_ependyma_morphology1.15725316
56MP0001929_abnormal_gametogenesis1.14351346
57MP0008995_early_reproductive_senescence1.12822554
58MP0000647_abnormal_sebaceous_gland1.12000967
59MP0005310_abnormal_salivary_gland1.10005790
60MP0003943_abnormal_hepatobiliary_system1.09345557
61MP0002928_abnormal_bile_duct1.08610939
62MP0002210_abnormal_sex_determination1.08260558
63MP0002277_abnormal_respiratory_mucosa1.07171766
64MP0003890_abnormal_embryonic-extraembry1.06566250
65MP0002837_dystrophic_cardiac_calcinosis1.05440937
66MP0003698_abnormal_male_reproductive1.04982491
67MP0002638_abnormal_pupillary_reflex1.02360768
68MP0002272_abnormal_nervous_system1.02333659
69MP0003718_maternal_effect1.01977926
70MP0001984_abnormal_olfaction1.00928789
71MP0009745_abnormal_behavioral_response1.00487023
72MP0000653_abnormal_sex_gland0.99905433
73MP0001145_abnormal_male_reproductive0.97679215
74MP0005195_abnormal_posterior_eye0.97613541
75MP0009703_decreased_birth_body0.96575365
76MP0009053_abnormal_anal_canal0.95490656
77MP0003693_abnormal_embryo_hatching0.95245332
78MP0003755_abnormal_palate_morphology0.94638923
79MP0001286_abnormal_eye_development0.93536646
80MP0001919_abnormal_reproductive_system0.93206708
81MP0001529_abnormal_vocalization0.92642156
82MP0002557_abnormal_social/conspecific_i0.91399962
83MP0004924_abnormal_behavior0.90254363
84MP0005386_behavior/neurological_phenoty0.90254363
85MP0002067_abnormal_sensory_capabilities0.89158162
86MP0004215_abnormal_myocardial_fiber0.87006653
87MP0005391_vision/eye_phenotype0.86622102
88MP0002282_abnormal_trachea_morphology0.86141219
89MP0004147_increased_porphyrin_level0.84229511
90MP0002090_abnormal_vision0.83662856
91MP0002572_abnormal_emotion/affect_behav0.82881052
92MP0002752_abnormal_somatic_nervous0.81381128
93MP0000428_abnormal_craniofacial_morphol0.80468897
94MP0000026_abnormal_inner_ear0.79704631
95MP0001119_abnormal_female_reproductive0.79273550
96MP0002751_abnormal_autonomic_nervous0.79146540
97MP0001324_abnormal_eye_pigmentation0.78801211
98MP0010678_abnormal_skin_adnexa0.78463087
99MP0008961_abnormal_basal_metabolism0.77731564
100MP0002822_catalepsy0.77243952

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.56039635
2True hermaphroditism (HP:0010459)3.91501206
3Pancreatic cysts (HP:0001737)3.74133539
4Abnormality of midbrain morphology (HP:0002418)3.64021734
5Molar tooth sign on MRI (HP:0002419)3.64021734
6Chronic hepatic failure (HP:0100626)3.57248911
7Gait imbalance (HP:0002141)3.55294776
8Congenital primary aphakia (HP:0007707)3.53491802
9Medial flaring of the eyebrow (HP:0010747)3.48773723
10Pancreatic fibrosis (HP:0100732)3.48624021
11Nephronophthisis (HP:0000090)3.34086279
12Nephrogenic diabetes insipidus (HP:0009806)3.32180596
13Hyperventilation (HP:0002883)2.92919271
14Abnormality of the renal medulla (HP:0100957)2.91572970
15Genital tract atresia (HP:0001827)2.90537824
16Abnormality of the renal cortex (HP:0011035)2.89281842
17Poor coordination (HP:0002370)2.85042717
18Vaginal atresia (HP:0000148)2.80554405
19Abnormality of the labia minora (HP:0012880)2.78757122
20Bile duct proliferation (HP:0001408)2.74829201
21Abnormal biliary tract physiology (HP:0012439)2.74829201
22Colon cancer (HP:0003003)2.69723796
23Renal cortical cysts (HP:0000803)2.67491579
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.62657513
25Intestinal atresia (HP:0011100)2.53985426
26Postaxial hand polydactyly (HP:0001162)2.52610590
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.46045336
28Postaxial foot polydactyly (HP:0001830)2.44611233
29Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.38483874
30Short 1st metacarpal (HP:0010034)2.38483874
31Male pseudohermaphroditism (HP:0000037)2.37013289
32Gaze-evoked nystagmus (HP:0000640)2.33464411
33Neoplasm of the oral cavity (HP:0100649)2.33242484
34Congenital stationary night blindness (HP:0007642)2.31674787
35Drooling (HP:0002307)2.31389006
36Broad foot (HP:0001769)2.30573251
37Hepatoblastoma (HP:0002884)2.29358813
38Protruding tongue (HP:0010808)2.23257213
39Hyperglycinemia (HP:0002154)2.21292236
40Abnormality of the 1st metacarpal (HP:0010009)2.14091563
41Tented upper lip vermilion (HP:0010804)2.12810100
42Megalencephaly (HP:0001355)2.11243843
43Excessive salivation (HP:0003781)2.11064344
44Congenital hepatic fibrosis (HP:0002612)2.10358538
45Tubular atrophy (HP:0000092)2.10358287
46Broad-based gait (HP:0002136)2.10051826
47Cystic liver disease (HP:0006706)2.08956341
48Preaxial hand polydactyly (HP:0001177)2.07503775
49Facial hemangioma (HP:0000329)2.06156982
50Ectopic kidney (HP:0000086)2.02202541
51Anencephaly (HP:0002323)2.01159980
52Short tibia (HP:0005736)1.99572013
53Narrow forehead (HP:0000341)1.96679470
54Astigmatism (HP:0000483)1.96530748
55Decreased testicular size (HP:0008734)1.96153772
56Sloping forehead (HP:0000340)1.94556040
57Aplasia/Hypoplasia of the lens (HP:0008063)1.93902870
58Tubulointerstitial nephritis (HP:0001970)1.92621725
59Short foot (HP:0001773)1.91341005
60Supernumerary spleens (HP:0009799)1.90773476
61Abnormality of the aortic arch (HP:0012303)1.90570274
62Specific learning disability (HP:0001328)1.89637263
63Attenuation of retinal blood vessels (HP:0007843)1.88901230
64Polydipsia (HP:0001959)1.86749239
65Abnormal drinking behavior (HP:0030082)1.86749239
66Widely spaced teeth (HP:0000687)1.83719096
67Oligodactyly (HP:0012165)1.83610592
68Abnormality of the ischium (HP:0003174)1.82340448
69Optic nerve hypoplasia (HP:0000609)1.81113238
70Short 4th metacarpal (HP:0010044)1.79114137
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79114137
72Degeneration of the lateral corticospinal tracts (HP:0002314)1.78364229
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78364229
74Dandy-Walker malformation (HP:0001305)1.77503786
75Abnormality of the metopic suture (HP:0005556)1.76690809
76Abnormality of the astrocytes (HP:0100707)1.75486913
77Astrocytoma (HP:0009592)1.75486913
78Febrile seizures (HP:0002373)1.74970051
79Hemiparesis (HP:0001269)1.74427919
80Hypoplastic iliac wings (HP:0002866)1.74173132
81Glioma (HP:0009733)1.73447030
82Hypoplastic ischia (HP:0003175)1.73086358
83Multicystic kidney dysplasia (HP:0000003)1.72961296
84Oligodactyly (hands) (HP:0001180)1.72354567
85Abnormal lung lobation (HP:0002101)1.70004239
86Progressive cerebellar ataxia (HP:0002073)1.68070492
87Focal motor seizures (HP:0011153)1.67694872
88Micropenis (HP:0000054)1.67556258
89Genetic anticipation (HP:0003743)1.66106323
90Calf muscle hypertrophy (HP:0008981)1.64661707
91Short phalanx of the thumb (HP:0009660)1.63858968
92Type II lissencephaly (HP:0007260)1.62759218
93Abnormality of chromosome stability (HP:0003220)1.62296179
94Absent speech (HP:0001344)1.62030967
95Prominent nasal bridge (HP:0000426)1.61890968
96Septo-optic dysplasia (HP:0100842)1.61852525
97Sclerocornea (HP:0000647)1.61620285
98Ependymoma (HP:0002888)1.61020931
99Median cleft lip (HP:0000161)1.60872787
100Abnormality of lateral ventricle (HP:0030047)1.60510800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.00656977
2PNCK3.85569718
3MAP4K23.18201698
4BRSK23.13008739
5CAMK1G2.98760898
6CASK2.83461870
7WNK32.62124174
8NUAK12.48745393
9CAMK1D2.30246719
10ACVR1B2.24952384
11ERBB32.11028943
12WEE12.09586046
13MAPK131.98579416
14TNIK1.79298636
15MKNK21.67768555
16PINK11.56649453
17EPHA31.55536584
18BMPR1B1.53684481
19SGK21.51222741
20LATS11.46156645
21CAMKK21.36989421
22NTRK31.30409971
23INSRR1.30256923
24TRIM281.29494691
25MAP3K41.27305591
26AKT31.23042245
27CCNB11.22344501
28PAK31.20325305
29TNK21.19237232
30NLK1.19079030
31SGK2231.18496877
32SGK4941.18496877
33BRD41.16793576
34BCR1.14074685
35EPHA41.10651312
36ZAK1.09021150
37MARK31.01869008
38MKNK11.01391132
39TSSK60.93601646
40GRK10.91933098
41RPS6KA40.91352386
42STK30.90478562
43DAPK20.89546494
44ADRBK20.88189905
45PLK30.85046606
46OXSR10.82305403
47IRAK10.81207455
48MARK10.80850842
49FGFR20.79772933
50CAMK10.79664362
51STK38L0.78021545
52VRK10.77356809
53OBSCN0.76730960
54PKN10.74944292
55PRKD20.74866351
56PRKCE0.73538179
57STK390.73217490
58CDK30.72168434
59CSNK1G10.71166999
60EPHB20.70777465
61SGK30.69673567
62PASK0.69243143
63BCKDK0.67983967
64FER0.67793797
65PLK10.67729403
66PLK20.67271051
67DYRK30.66792325
68PLK40.59992631
69CAMK40.56777578
70ATR0.56751871
71RPS6KA50.56588548
72SGK10.55238924
73BRSK10.55104448
74TAOK30.55013513
75ATM0.54287792
76STK110.53671101
77PRKD30.53301577
78PRKCG0.51250568
79MINK10.51082704
80CSNK1G20.48207919
81EIF2AK30.47432480
82DYRK1B0.46323326
83SRPK10.43936757
84PRKAA20.43726050
85TGFBR10.42299430
86PRKAA10.41389193
87YES10.40433981
88CDC70.38733684
89MST40.38484337
90NTRK20.38016942
91NEK20.37604454
92TAOK10.37506255
93BUB10.37498831
94PRKCQ0.37309447
95CAMK2A0.36910697
96CSNK1A10.36030629
97GRK70.35165122
98TIE10.34796502
99CAMKK10.33730869
100PIM10.33677504

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.29036496
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.06996968
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.49121123
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47674637
5Phototransduction_Homo sapiens_hsa047442.46496164
6Butanoate metabolism_Homo sapiens_hsa006502.45923441
7Propanoate metabolism_Homo sapiens_hsa006402.39494842
8Nicotine addiction_Homo sapiens_hsa050332.37270885
9Fanconi anemia pathway_Homo sapiens_hsa034602.37257656
10Protein export_Homo sapiens_hsa030602.35213030
11Basal transcription factors_Homo sapiens_hsa030222.08294691
12Circadian rhythm_Homo sapiens_hsa047101.85928271
13Homologous recombination_Homo sapiens_hsa034401.78821516
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77176042
15RNA degradation_Homo sapiens_hsa030181.74120393
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70808661
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62933180
18Fatty acid biosynthesis_Homo sapiens_hsa000611.56536865
19Steroid biosynthesis_Homo sapiens_hsa001001.56341007
20Ether lipid metabolism_Homo sapiens_hsa005651.55263858
21Basal cell carcinoma_Homo sapiens_hsa052171.51849397
22Nitrogen metabolism_Homo sapiens_hsa009101.46260933
23Taste transduction_Homo sapiens_hsa047421.41301594
24Linoleic acid metabolism_Homo sapiens_hsa005911.40046069
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36530712
26Selenocompound metabolism_Homo sapiens_hsa004501.33758854
27Regulation of autophagy_Homo sapiens_hsa041401.33626111
28Olfactory transduction_Homo sapiens_hsa047401.29715857
29Hedgehog signaling pathway_Homo sapiens_hsa043401.27492843
30Tryptophan metabolism_Homo sapiens_hsa003801.26312322
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22256130
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18858591
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17230816
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16413951
35Oocyte meiosis_Homo sapiens_hsa041141.13337682
36Circadian entrainment_Homo sapiens_hsa047131.13025253
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08207299
38Morphine addiction_Homo sapiens_hsa050321.07144528
39Peroxisome_Homo sapiens_hsa041461.05750205
40Lysine degradation_Homo sapiens_hsa003101.03876448
41Insulin secretion_Homo sapiens_hsa049111.03598252
42p53 signaling pathway_Homo sapiens_hsa041151.01341971
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.01275975
44TGF-beta signaling pathway_Homo sapiens_hsa043501.00879639
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00878803
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.96653195
47ABC transporters_Homo sapiens_hsa020100.94544555
48Retinol metabolism_Homo sapiens_hsa008300.91598846
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91364873
50Dopaminergic synapse_Homo sapiens_hsa047280.90414095
51GABAergic synapse_Homo sapiens_hsa047270.88971378
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87820804
53Cell cycle_Homo sapiens_hsa041100.85864058
54Glutamatergic synapse_Homo sapiens_hsa047240.85469523
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84734248
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.80598710
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80312049
58Collecting duct acid secretion_Homo sapiens_hsa049660.74521698
59Caffeine metabolism_Homo sapiens_hsa002320.73976156
60Chemical carcinogenesis_Homo sapiens_hsa052040.72399402
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72368626
62Prostate cancer_Homo sapiens_hsa052150.71265968
63RNA transport_Homo sapiens_hsa030130.70169745
64beta-Alanine metabolism_Homo sapiens_hsa004100.69995424
65cAMP signaling pathway_Homo sapiens_hsa040240.69146975
66Amphetamine addiction_Homo sapiens_hsa050310.68397713
67Wnt signaling pathway_Homo sapiens_hsa043100.67705235
68Renin secretion_Homo sapiens_hsa049240.66116272
69RNA polymerase_Homo sapiens_hsa030200.65202989
70Calcium signaling pathway_Homo sapiens_hsa040200.65184544
71Serotonergic synapse_Homo sapiens_hsa047260.62600174
72Salivary secretion_Homo sapiens_hsa049700.60890817
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60687788
74Hippo signaling pathway_Homo sapiens_hsa043900.60564010
75Mineral absorption_Homo sapiens_hsa049780.59511656
76FoxO signaling pathway_Homo sapiens_hsa040680.59450726
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58023819
78Oxidative phosphorylation_Homo sapiens_hsa001900.57654857
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57257255
80Fatty acid metabolism_Homo sapiens_hsa012120.55526294
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54907864
82Long-term depression_Homo sapiens_hsa047300.54668920
83Vitamin B6 metabolism_Homo sapiens_hsa007500.53995465
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51932995
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.50750551
86Base excision repair_Homo sapiens_hsa034100.50341908
87Cocaine addiction_Homo sapiens_hsa050300.46756645
88Glucagon signaling pathway_Homo sapiens_hsa049220.44928204
89mRNA surveillance pathway_Homo sapiens_hsa030150.44378048
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43936191
91Nucleotide excision repair_Homo sapiens_hsa034200.42995881
92Mismatch repair_Homo sapiens_hsa034300.41692320
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41498440
94Ovarian steroidogenesis_Homo sapiens_hsa049130.40345195
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39613007
96Glycerolipid metabolism_Homo sapiens_hsa005610.38807282
97Cholinergic synapse_Homo sapiens_hsa047250.37757250
98Metabolic pathways_Homo sapiens_hsa011000.36586373
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36180730
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.36113304

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