ZNF614

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.69230271
2somatic hypermutation of immunoglobulin genes (GO:0016446)4.21960419
3somatic diversification of immune receptors via somatic mutation (GO:0002566)4.21960419
4regulation of centriole replication (GO:0046599)3.86923509
5regulation of mitotic spindle checkpoint (GO:1903504)3.79613342
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.79613342
7negative regulation of DNA-dependent DNA replication (GO:2000104)3.78280583
8nuclear pore complex assembly (GO:0051292)3.71241646
9negative regulation of DNA recombination (GO:0045910)3.63364609
10nuclear pore organization (GO:0006999)3.60808192
11synapsis (GO:0007129)3.53461067
12protein localization to kinetochore (GO:0034501)3.52930685
13regulation of helicase activity (GO:0051095)3.49750960
14spindle checkpoint (GO:0031577)3.45679526
15double-strand break repair via nonhomologous end joining (GO:0006303)3.42634474
16non-recombinational repair (GO:0000726)3.42634474
17mitotic spindle checkpoint (GO:0071174)3.41524235
18chromatin remodeling at centromere (GO:0031055)3.39561816
19DNA ligation (GO:0006266)3.39497793
20CENP-A containing nucleosome assembly (GO:0034080)3.35849509
21negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.34333381
22negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34333381
23negative regulation of mitotic sister chromatid segregation (GO:0033048)3.34333381
24negative regulation of mitotic sister chromatid separation (GO:2000816)3.34333381
25negative regulation of sister chromatid segregation (GO:0033046)3.34333381
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.32748317
27negative regulation of chromosome segregation (GO:0051985)3.28577497
28mitotic metaphase plate congression (GO:0007080)3.25560336
29histone exchange (GO:0043486)3.23421686
30somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.20560215
31somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.20560215
32isotype switching (GO:0045190)3.20560215
33metaphase plate congression (GO:0051310)3.19688273
34maturation of 5.8S rRNA (GO:0000460)3.18172044
35ribosome assembly (GO:0042255)3.15936218
36resolution of meiotic recombination intermediates (GO:0000712)3.14539520
37mitotic sister chromatid cohesion (GO:0007064)3.11370463
38spindle assembly checkpoint (GO:0071173)3.11189527
39mitotic spindle assembly checkpoint (GO:0007094)3.09678809
40replication fork processing (GO:0031297)3.09654899
41DNA integration (GO:0015074)3.07210821
42regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02599424
43regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02599424
44cullin deneddylation (GO:0010388)3.02457760
45regulation of centrosome cycle (GO:0046605)3.01486966
46regulation of centrosome duplication (GO:0010824)3.00634982
47establishment of integrated proviral latency (GO:0075713)2.99517192
48regulation of mitotic sister chromatid separation (GO:0010965)2.97858675
49regulation of mitotic sister chromatid segregation (GO:0033047)2.97858675
50regulation of sister chromatid segregation (GO:0033045)2.97858675
51regulation of DNA endoreduplication (GO:0032875)2.96906349
52mitochondrial RNA metabolic process (GO:0000959)2.96782735
53meiotic chromosome segregation (GO:0045132)2.96065049
54pseudouridine synthesis (GO:0001522)2.95807805
55histone H2A acetylation (GO:0043968)2.94981815
56somatic recombination of immunoglobulin gene segments (GO:0016447)2.93291005
57mitotic nuclear envelope disassembly (GO:0007077)2.93056510
58regulation of gene silencing by RNA (GO:0060966)2.90554013
59regulation of posttranscriptional gene silencing (GO:0060147)2.90554013
60regulation of gene silencing by miRNA (GO:0060964)2.90554013
61pre-miRNA processing (GO:0031054)2.90446020
62anterior/posterior axis specification, embryo (GO:0008595)2.89412232
63protein localization to chromosome, centromeric region (GO:0071459)2.88277770
64monoubiquitinated protein deubiquitination (GO:0035520)2.86589269
65regulation of translation, ncRNA-mediated (GO:0045974)2.84846004
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.84846004
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.84846004
68DNA replication-dependent nucleosome assembly (GO:0006335)2.84201224
69DNA replication-dependent nucleosome organization (GO:0034723)2.84201224
70reciprocal DNA recombination (GO:0035825)2.83516785
71reciprocal meiotic recombination (GO:0007131)2.83516785
72IMP biosynthetic process (GO:0006188)2.83014221
73DNA replication checkpoint (GO:0000076)2.82548255
74somatic diversification of immunoglobulins (GO:0016445)2.81822226
75pore complex assembly (GO:0046931)2.80706266
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.78206786
77membrane disassembly (GO:0030397)2.77767068
78nuclear envelope disassembly (GO:0051081)2.77767068
79single strand break repair (GO:0000012)2.76938045
80histone mRNA metabolic process (GO:0008334)2.76846701
81mitotic G2/M transition checkpoint (GO:0044818)2.76557911
82attachment of spindle microtubules to kinetochore (GO:0008608)2.75515792
83DNA catabolic process, exonucleolytic (GO:0000738)2.75043679
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74612012
85peptidyl-histidine modification (GO:0018202)2.73733014
86regulation of chromosome segregation (GO:0051983)2.72857635
87somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.72448727
88somatic cell DNA recombination (GO:0016444)2.72448727
89protein deneddylation (GO:0000338)2.71561740
90DNA replication-independent nucleosome assembly (GO:0006336)2.71295150
91DNA replication-independent nucleosome organization (GO:0034724)2.71295150
92kinetochore organization (GO:0051383)2.68498925
93response to X-ray (GO:0010165)2.68100660
94somatic diversification of immune receptors (GO:0002200)2.65902576
95piRNA metabolic process (GO:0034587)2.63833821
96regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.63553199
97proteasome assembly (GO:0043248)2.63512690
98sister chromatid segregation (GO:0000819)2.63298011
99negative regulation of mitosis (GO:0045839)2.63017212
100recombinational repair (GO:0000725)2.61614196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.91601092
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.64677225
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35682331
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32558158
5ZNF274_21170338_ChIP-Seq_K562_Hela3.25429102
6IGF1R_20145208_ChIP-Seq_DFB_Human2.85824264
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76399425
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.64609464
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.59681909
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38474195
11ELK1_19687146_ChIP-ChIP_HELA_Human2.37434863
12FUS_26573619_Chip-Seq_HEK293_Human2.34705982
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27898407
14EWS_26573619_Chip-Seq_HEK293_Human2.27565884
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.27540957
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24714953
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.12122660
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04552544
19PADI4_21655091_ChIP-ChIP_MCF-7_Human2.01432351
20TAF15_26573619_Chip-Seq_HEK293_Human1.96764111
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96654405
22VDR_22108803_ChIP-Seq_LS180_Human1.94653737
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.90891647
24* VDR_23849224_ChIP-Seq_CD4+_Human1.89475101
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88112304
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85902686
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82787773
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76753862
29P300_19829295_ChIP-Seq_ESCs_Human1.76445533
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76435673
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74978059
32AR_21909140_ChIP-Seq_LNCAP_Human1.74502722
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.72100951
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71996281
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71924583
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67324250
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67135238
38GBX2_23144817_ChIP-Seq_PC3_Human1.67019902
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64745190
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.63949622
41MYC_18940864_ChIP-ChIP_HL60_Human1.61116985
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56034599
43FOXP3_21729870_ChIP-Seq_TREG_Human1.55180776
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54721762
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.54166896
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46765541
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44076487
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39478747
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.38879836
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38625921
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.38519302
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.38358256
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.35313866
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32762468
55DCP1A_22483619_ChIP-Seq_HELA_Human1.32469168
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31466781
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28487108
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24127053
59CBP_20019798_ChIP-Seq_JUKART_Human1.23929670
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23929670
61IRF1_19129219_ChIP-ChIP_H3396_Human1.22355592
62ER_23166858_ChIP-Seq_MCF-7_Human1.21347603
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20935669
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19550962
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18337522
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18104378
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16542809
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14918431
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14135215
70GABP_19822575_ChIP-Seq_HepG2_Human1.12315227
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10680749
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10632121
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10542595
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05181061
75TTF2_22483619_ChIP-Seq_HELA_Human1.04506979
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03998458
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03202171
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.02447082
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00042110
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98807302
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98605852
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98096647
83SMAD3_21741376_ChIP-Seq_EPCs_Human0.97927539
84RNF2_27304074_Chip-Seq_NSC_Mouse0.97829318
85STAT3_23295773_ChIP-Seq_U87_Human0.96415980
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95732531
87SMAD4_21799915_ChIP-Seq_A2780_Human0.94809093
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94744385
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94130439
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93818757
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93034903
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92534001
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92420347
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91173680
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90706375
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89463776
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89463776
98AR_25329375_ChIP-Seq_VCAP_Human0.89158421
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88631969
100MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87807995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.52143738
2MP0008057_abnormal_DNA_replication3.37862912
3MP0010094_abnormal_chromosome_stability3.36556300
4MP0003693_abnormal_embryo_hatching2.92930870
5MP0003890_abnormal_embryonic-extraembry2.85732917
6MP0008877_abnormal_DNA_methylation2.72113623
7MP0003111_abnormal_nucleus_morphology2.51290765
8MP0004957_abnormal_blastocyst_morpholog2.43774051
9MP0000569_abnormal_digit_pigmentation2.35367566
10MP0003077_abnormal_cell_cycle2.26413245
11MP0003718_maternal_effect2.14304042
12MP0003315_abnormal_perineum_morphology2.11430014
13MP0000537_abnormal_urethra_morphology1.98695560
14MP0000516_abnormal_urinary_system1.96409361
15MP0005367_renal/urinary_system_phenotyp1.96409361
16MP0001529_abnormal_vocalization1.93472134
17MP0002102_abnormal_ear_morphology1.90050393
18MP0003567_abnormal_fetal_cardiomyocyte1.85073694
19MP0003941_abnormal_skin_development1.81360466
20MP0006292_abnormal_olfactory_placode1.74643295
21MP0001293_anophthalmia1.73956944
22MP0003136_yellow_coat_color1.72728531
23MP0002938_white_spotting1.63993237
24MP0003937_abnormal_limbs/digits/tail_de1.62157836
25MP0008932_abnormal_embryonic_tissue1.59648842
26MP0005187_abnormal_penis_morphology1.57346332
27MP0004133_heterotaxia1.55288216
28MP0000647_abnormal_sebaceous_gland1.54965761
29MP0003122_maternal_imprinting1.54332845
30MP0002822_catalepsy1.52643965
31MP0009697_abnormal_copulation1.51403837
32MP0003121_genomic_imprinting1.49186683
33MP0002254_reproductive_system_inflammat1.46014305
34MP0003646_muscle_fatigue1.43653963
35MP0001929_abnormal_gametogenesis1.41453512
36MP0003119_abnormal_digestive_system1.40966291
37MP0008007_abnormal_cellular_replicative1.37189392
38MP0009672_abnormal_birth_weight1.29440382
39MP0002210_abnormal_sex_determination1.27326285
40MP0002084_abnormal_developmental_patter1.24711345
41MP0001145_abnormal_male_reproductive1.24288907
42MP0002234_abnormal_pharynx_morphology1.23314579
43MP0005645_abnormal_hypothalamus_physiol1.21955692
44MP0001672_abnormal_embryogenesis/_devel1.21576613
45MP0005380_embryogenesis_phenotype1.21576613
46MP0003698_abnormal_male_reproductive1.19815790
47MP0000653_abnormal_sex_gland1.18548530
48MP0002160_abnormal_reproductive_system1.17994816
49MP0001730_embryonic_growth_arrest1.17465065
50MP0003221_abnormal_cardiomyocyte_apopto1.14578230
51MP0002009_preneoplasia1.14335658
52MP0004145_abnormal_muscle_electrophysio1.14129488
53MP0006035_abnormal_mitochondrial_morpho1.13110637
54MP0001286_abnormal_eye_development1.12605380
55MP0009703_decreased_birth_body1.12134230
56MP0003195_calcinosis1.11522497
57MP0001697_abnormal_embryo_size1.10304079
58MP0004197_abnormal_fetal_growth/weight/1.09355997
59MP0006276_abnormal_autonomic_nervous1.07735736
60MP0002085_abnormal_embryonic_tissue1.06617198
61MP0005253_abnormal_eye_physiology1.05998030
62MP0003984_embryonic_growth_retardation1.05636337
63MP0002088_abnormal_embryonic_growth/wei1.04900758
64MP0010307_abnormal_tumor_latency1.03724126
65MP0005551_abnormal_eye_electrophysiolog1.03012330
66MP0004147_increased_porphyrin_level1.02375086
67MP0002638_abnormal_pupillary_reflex1.01970272
68MP0000372_irregular_coat_pigmentation1.01613638
69MP0005410_abnormal_fertilization0.97378538
70MP0000350_abnormal_cell_proliferation0.96578632
71MP0008995_early_reproductive_senescence0.96156958
72MP0002233_abnormal_nose_morphology0.95099254
73MP0003787_abnormal_imprinting0.93420618
74MP0001177_atelectasis0.93399290
75MP0002111_abnormal_tail_morphology0.91543580
76MP0000383_abnormal_hair_follicle0.91516876
77MP0000631_abnormal_neuroendocrine_gland0.91398310
78MP0003861_abnormal_nervous_system0.91397740
79MP0002697_abnormal_eye_size0.90917332
80MP0003786_premature_aging0.88449061
81MP0003880_abnormal_central_pattern0.87369756
82MP0002090_abnormal_vision0.86626881
83MP0001299_abnormal_eye_distance/0.85975791
84MP0002736_abnormal_nociception_after0.85949473
85MP0006072_abnormal_retinal_apoptosis0.85596273
86MP0001119_abnormal_female_reproductive0.85507881
87MP0001486_abnormal_startle_reflex0.85174097
88MP0002751_abnormal_autonomic_nervous0.84129617
89MP0001984_abnormal_olfaction0.82097497
90MP0002080_prenatal_lethality0.81133274
91MP0001324_abnormal_eye_pigmentation0.80800313
92MP0005075_abnormal_melanosome_morpholog0.80352376
93MP0005391_vision/eye_phenotype0.80003724
94MP0004264_abnormal_extraembryonic_tissu0.79808704
95MP0003385_abnormal_body_wall0.79561453
96MP0003755_abnormal_palate_morphology0.79434293
97MP0005647_abnormal_sex_gland0.77410991
98MP0004215_abnormal_myocardial_fiber0.77319606
99MP0000778_abnormal_nervous_system0.77100484
100MP0000427_abnormal_hair_cycle0.76684661

Predicted human phenotypes

RankGene SetZ-score
1Nephroblastoma (Wilms tumor) (HP:0002667)3.31368337
2Embryonal renal neoplasm (HP:0011794)3.15485052
3Colon cancer (HP:0003003)3.06768302
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00979097
5Chromsome breakage (HP:0040012)2.92247876
6Abnormal lung lobation (HP:0002101)2.82470362
7Gonadotropin excess (HP:0000837)2.79393389
8Abnormality of chromosome stability (HP:0003220)2.78038961
9Medulloblastoma (HP:0002885)2.76422975
10Abnormality of the labia minora (HP:0012880)2.74628709
11Hyperglycinemia (HP:0002154)2.73358338
12Abnormality of the ileum (HP:0001549)2.72719639
13Meckel diverticulum (HP:0002245)2.67102523
14Abnormality of alanine metabolism (HP:0010916)2.57423663
15Hyperalaninemia (HP:0003348)2.57423663
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57423663
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.56199850
18Intestinal atresia (HP:0011100)2.52183102
19Rhabdomyosarcoma (HP:0002859)2.44251800
20Aplasia/Hypoplasia of the sternum (HP:0006714)2.37031666
21Volvulus (HP:0002580)2.35019974
22Glioma (HP:0009733)2.31796074
23Birth length less than 3rd percentile (HP:0003561)2.28747459
24True hermaphroditism (HP:0010459)2.27744771
25Pancreatic islet-cell hyperplasia (HP:0004510)2.24703970
26Methylmalonic acidemia (HP:0002912)2.23148086
27Hepatoblastoma (HP:0002884)2.22150336
28Progressive inability to walk (HP:0002505)2.21866337
29Pancreatic cysts (HP:0001737)2.21436742
30Ependymoma (HP:0002888)2.18250473
31Small intestinal stenosis (HP:0012848)2.17936037
32Duodenal stenosis (HP:0100867)2.17936037
33Abnormality of serum amino acid levels (HP:0003112)2.17134339
34Abnormality of the preputium (HP:0100587)2.16673687
35Hyperglycinuria (HP:0003108)2.11873046
36Neoplasm of the adrenal cortex (HP:0100641)2.11708634
37Sloping forehead (HP:0000340)2.10127594
38Abnormality of glycine metabolism (HP:0010895)2.07983672
39Abnormality of serine family amino acid metabolism (HP:0010894)2.07983672
40Cortical dysplasia (HP:0002539)2.06412405
41Embryonal neoplasm (HP:0002898)2.05230743
42Abnormality of the duodenum (HP:0002246)2.03523493
43Biliary tract neoplasm (HP:0100574)2.02922955
44Genital tract atresia (HP:0001827)1.97840032
45Absent radius (HP:0003974)1.97746174
46Pancreatic fibrosis (HP:0100732)1.96241689
47Aplasia/Hypoplasia of the tibia (HP:0005772)1.95542657
48Vaginal atresia (HP:0000148)1.94607439
49Abnormality of the pons (HP:0007361)1.91743183
50Medial flaring of the eyebrow (HP:0010747)1.90807152
51Inability to walk (HP:0002540)1.90248152
52Astrocytoma (HP:0009592)1.89306325
53Abnormality of the astrocytes (HP:0100707)1.89306325
54Abnormality of the parathyroid morphology (HP:0011766)1.88800225
55Hypoplasia of the pons (HP:0012110)1.88786792
56Absent forearm bone (HP:0003953)1.87783057
57Aplasia involving forearm bones (HP:0009822)1.87783057
58Chronic hepatic failure (HP:0100626)1.87081934
59Neoplasm of the colon (HP:0100273)1.86145219
60Supernumerary spleens (HP:0009799)1.85521979
61Attenuation of retinal blood vessels (HP:0007843)1.85306291
62Abnormality of methionine metabolism (HP:0010901)1.83898612
63Nephronophthisis (HP:0000090)1.83700402
64Congenital primary aphakia (HP:0007707)1.81045899
65Lissencephaly (HP:0001339)1.79052797
66Nephrogenic diabetes insipidus (HP:0009806)1.76992086
67Gastrointestinal atresia (HP:0002589)1.76559691
68Septo-optic dysplasia (HP:0100842)1.75685590
69Dandy-Walker malformation (HP:0001305)1.74257289
70Short tibia (HP:0005736)1.73723608
71Gait imbalance (HP:0002141)1.72089733
72Myelodysplasia (HP:0002863)1.71021012
73Fibular aplasia (HP:0002990)1.70573815
74Triphalangeal thumb (HP:0001199)1.70509878
75Anal stenosis (HP:0002025)1.70208421
76Tubulointerstitial nephritis (HP:0001970)1.69788217
77Partial agenesis of the corpus callosum (HP:0001338)1.69571106
78Abnormality of homocysteine metabolism (HP:0010919)1.68226817
79Homocystinuria (HP:0002156)1.68226817
80Agnosia (HP:0010524)1.67028539
81Bifid tongue (HP:0010297)1.66998650
82Stenosis of the external auditory canal (HP:0000402)1.65762171
83Abnormal protein glycosylation (HP:0012346)1.64387366
84Abnormal glycosylation (HP:0012345)1.64387366
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64387366
86Abnormal protein N-linked glycosylation (HP:0012347)1.64387366
87Cerebellar dysplasia (HP:0007033)1.64049395
88Preaxial hand polydactyly (HP:0001177)1.63635791
89Ectopic kidney (HP:0000086)1.63450653
90Papillary thyroid carcinoma (HP:0002895)1.63042639
91Azoospermia (HP:0000027)1.62549427
92Abnormal spermatogenesis (HP:0008669)1.61756049
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61505743
94Absent eyebrow (HP:0002223)1.60044649
95Hyperinsulinemic hypoglycemia (HP:0000825)1.59833413
96Poor coordination (HP:0002370)1.59756927
97Hypoplastic pelvis (HP:0008839)1.59711183
98Abnormal auditory evoked potentials (HP:0006958)1.59673795
99Gaze-evoked nystagmus (HP:0000640)1.59600550
100Neoplasm of striated muscle (HP:0009728)1.59577893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK2.90978466
2SRPK12.75303221
3MKNK22.69543500
4TTK2.67136660
5MKNK12.61235292
6ACVR1B2.58696838
7BRSK22.50933479
8TRIM282.49976065
9BRD42.41546728
10BUB12.38684061
11WNK32.33053598
12CDC72.29749851
13LATS12.25010864
14STK38L2.23814338
15NUAK12.21836150
16PLK42.13845768
17TSSK62.09667444
18BCR2.01029308
19MAP3K41.99128053
20FRK1.98253270
21WEE11.94528533
22MAP4K21.93910606
23BMPR1B1.81094768
24EIF2AK31.74094513
25ERBB31.69200339
26PBK1.65910660
27TNIK1.65300784
28PLK31.65008408
29PNCK1.62624040
30NEK11.61144792
31DYRK31.56838013
32AKT31.50708534
33MAP2K71.42951319
34CAMK1G1.42535998
35CAMK1D1.40934769
36PLK11.25478207
37STK161.21620292
38CASK1.21202815
39MUSK1.17371436
40CSNK1G11.12118953
41ERBB41.06604430
42CCNB11.04971622
43ATR1.02073456
44MAPK130.99337966
45GRK10.98705816
46STK30.96047154
47VRK10.93262619
48RPS6KA40.92904087
49PLK20.91896182
50INSRR0.91333706
51CHEK20.89699209
52ATM0.84427101
53CSNK1G20.82200990
54CSNK1G30.81987954
55EIF2AK10.81692696
56TAF10.80571705
57PDK20.77925932
58CSNK1A1L0.76662899
59NME10.73977097
60MST40.73836887
61NLK0.73759987
62NEK20.73162983
63BRSK10.69996871
64ADRBK20.68368567
65AURKB0.67145866
66OXSR10.65557996
67PINK10.64085808
68CHEK10.63614420
69CDK190.56775923
70CDK70.56578407
71BRAF0.55055265
72CDK120.54985389
73TGFBR10.54613619
74PASK0.53970706
75CDK10.50425894
76VRK20.49508281
77FGFR10.45605769
78CSNK1E0.44245976
79OBSCN0.43583676
80PRKCE0.42761634
81WNK40.42731119
82STK390.41821559
83FER0.41618336
84CLK10.40522934
85CDK20.38685746
86YES10.38257049
87PRKDC0.37061981
88CSNK1D0.36924141
89RPS6KA50.35710684
90EIF2AK20.35161759
91NEK90.34635291
92DYRK20.33300908
93PRKCG0.32553537
94RAF10.32187832
95CDK30.32072432
96PIM10.30643176
97DYRK1A0.30035202
98CSNK2A20.29778643
99MAP3K100.29366280
100PKN10.26937065

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.43046610
2Mismatch repair_Homo sapiens_hsa034303.24143286
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20198006
4RNA transport_Homo sapiens_hsa030132.74882489
5Homologous recombination_Homo sapiens_hsa034402.67036112
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60947502
7Basal transcription factors_Homo sapiens_hsa030222.58931101
8Protein export_Homo sapiens_hsa030602.54941435
9Propanoate metabolism_Homo sapiens_hsa006402.54756091
10DNA replication_Homo sapiens_hsa030302.53404356
11Fanconi anemia pathway_Homo sapiens_hsa034602.43180230
12Selenocompound metabolism_Homo sapiens_hsa004502.35658725
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19951359
14RNA degradation_Homo sapiens_hsa030182.17742477
15Steroid biosynthesis_Homo sapiens_hsa001002.15297766
16Nucleotide excision repair_Homo sapiens_hsa034202.09703432
17Spliceosome_Homo sapiens_hsa030402.04480403
18Cell cycle_Homo sapiens_hsa041102.04422698
19One carbon pool by folate_Homo sapiens_hsa006702.01624209
20Proteasome_Homo sapiens_hsa030501.94586961
21RNA polymerase_Homo sapiens_hsa030201.94349879
22Base excision repair_Homo sapiens_hsa034101.90886062
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80799732
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78879238
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65758876
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.64609343
27mRNA surveillance pathway_Homo sapiens_hsa030151.56855178
28Fatty acid biosynthesis_Homo sapiens_hsa000611.46165864
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43782383
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43390220
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42373056
32Butanoate metabolism_Homo sapiens_hsa006501.35707728
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31883025
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21191514
35Pyruvate metabolism_Homo sapiens_hsa006201.19406711
36Nicotine addiction_Homo sapiens_hsa050331.15867586
37Fatty acid metabolism_Homo sapiens_hsa012121.11433453
38p53 signaling pathway_Homo sapiens_hsa041151.06462998
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03960076
40Taste transduction_Homo sapiens_hsa047421.00866058
41Oocyte meiosis_Homo sapiens_hsa041141.00531109
42Purine metabolism_Homo sapiens_hsa002300.98019995
43Pyrimidine metabolism_Homo sapiens_hsa002400.97996252
44Phototransduction_Homo sapiens_hsa047440.94516418
45Fatty acid elongation_Homo sapiens_hsa000620.93837411
46Vitamin digestion and absorption_Homo sapiens_hsa049770.92837445
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91660350
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83270131
49Lysine degradation_Homo sapiens_hsa003100.83123975
50Peroxisome_Homo sapiens_hsa041460.81317175
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79309617
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76846170
53TGF-beta signaling pathway_Homo sapiens_hsa043500.76228417
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75060652
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73405550
56Basal cell carcinoma_Homo sapiens_hsa052170.70656762
57Hippo signaling pathway_Homo sapiens_hsa043900.69301819
58Hedgehog signaling pathway_Homo sapiens_hsa043400.68725331
59Olfactory transduction_Homo sapiens_hsa047400.67642772
60Tryptophan metabolism_Homo sapiens_hsa003800.67059801
61Circadian rhythm_Homo sapiens_hsa047100.65450688
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64023689
63Ether lipid metabolism_Homo sapiens_hsa005650.58677994
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56210757
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.56124900
66Wnt signaling pathway_Homo sapiens_hsa043100.54910297
67N-Glycan biosynthesis_Homo sapiens_hsa005100.54121114
68Huntingtons disease_Homo sapiens_hsa050160.53710723
69Regulation of autophagy_Homo sapiens_hsa041400.51570883
70Alcoholism_Homo sapiens_hsa050340.50624479
71Metabolic pathways_Homo sapiens_hsa011000.50148830
72beta-Alanine metabolism_Homo sapiens_hsa004100.50088241
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49300572
74Oxidative phosphorylation_Homo sapiens_hsa001900.48310388
75Parkinsons disease_Homo sapiens_hsa050120.47559339
76Nitrogen metabolism_Homo sapiens_hsa009100.45690336
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41713854
78Systemic lupus erythematosus_Homo sapiens_hsa053220.41310321
79Biosynthesis of amino acids_Homo sapiens_hsa012300.40688279
80Carbon metabolism_Homo sapiens_hsa012000.40055176
81Fatty acid degradation_Homo sapiens_hsa000710.35991990
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33888882
83MicroRNAs in cancer_Homo sapiens_hsa052060.33331050
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33275673
85Thyroid cancer_Homo sapiens_hsa052160.29895589
86Linoleic acid metabolism_Homo sapiens_hsa005910.28602276
87Serotonergic synapse_Homo sapiens_hsa047260.26614924
88Tight junction_Homo sapiens_hsa045300.26016114
89Prostate cancer_Homo sapiens_hsa052150.25969879
90Glutathione metabolism_Homo sapiens_hsa004800.25341947
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24419274
92Adherens junction_Homo sapiens_hsa045200.24196398
93Colorectal cancer_Homo sapiens_hsa052100.23974239
94GABAergic synapse_Homo sapiens_hsa047270.23780726
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22799213
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22579622
97Viral carcinogenesis_Homo sapiens_hsa052030.19886569
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19783118
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19620481
100Arginine and proline metabolism_Homo sapiens_hsa003300.17748295

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