ZNF594

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.09501373
2response to pheromone (GO:0019236)3.85895782
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.81526506
4pyrimidine nucleobase catabolic process (GO:0006208)3.77552903
5neural tube formation (GO:0001841)3.51481607
6presynaptic membrane assembly (GO:0097105)3.49770600
7meiotic chromosome segregation (GO:0045132)3.42776289
8cilium or flagellum-dependent cell motility (GO:0001539)3.36993380
9neuron cell-cell adhesion (GO:0007158)3.33602113
10regulation of hippo signaling (GO:0035330)3.31067347
11postsynaptic membrane organization (GO:0001941)3.29633603
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.19555115
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19555115
14presynaptic membrane organization (GO:0097090)3.16807129
15somite development (GO:0061053)3.14311814
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.13793607
17protein localization to cilium (GO:0061512)3.12720166
18reciprocal DNA recombination (GO:0035825)3.09633439
19reciprocal meiotic recombination (GO:0007131)3.09633439
20nucleobase catabolic process (GO:0046113)3.05572697
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.01125406
22regulation of non-canonical Wnt signaling pathway (GO:2000050)3.00768955
23DNA double-strand break processing (GO:0000729)2.99988032
24intraciliary transport (GO:0042073)2.98659225
25epithelial cilium movement (GO:0003351)2.96554237
26axoneme assembly (GO:0035082)2.93874013
27peristalsis (GO:0030432)2.92811997
28detection of light stimulus involved in visual perception (GO:0050908)2.91927614
29detection of light stimulus involved in sensory perception (GO:0050962)2.91927614
30regulation of DNA endoreduplication (GO:0032875)2.91123291
31ubiquinone metabolic process (GO:0006743)2.90214013
32negative regulation of oligodendrocyte differentiation (GO:0048715)2.89533211
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88777169
34cilium organization (GO:0044782)2.86336932
35cilium assembly (GO:0042384)2.84688743
36cornea development in camera-type eye (GO:0061303)2.84588555
37negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82338405
38recombinational repair (GO:0000725)2.80839461
39double-strand break repair via homologous recombination (GO:0000724)2.78648329
40cilium morphogenesis (GO:0060271)2.77905338
41centriole replication (GO:0007099)2.77698661
42replication fork processing (GO:0031297)2.75329131
43water-soluble vitamin biosynthetic process (GO:0042364)2.71962372
44sympathetic nervous system development (GO:0048485)2.70527039
45neuronal action potential (GO:0019228)2.67354488
46transmission of nerve impulse (GO:0019226)2.66112825
47protein K6-linked ubiquitination (GO:0085020)2.63314209
48cilium movement (GO:0003341)2.60932268
49spinal cord motor neuron differentiation (GO:0021522)2.60822065
50microtubule anchoring (GO:0034453)2.60682975
51regulation of posttranscriptional gene silencing (GO:0060147)2.60491474
52regulation of gene silencing by miRNA (GO:0060964)2.60491474
53regulation of gene silencing by RNA (GO:0060966)2.60491474
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60342931
55protein-cofactor linkage (GO:0018065)2.59772744
56positive regulation of developmental pigmentation (GO:0048087)2.57633519
57limb development (GO:0060173)2.57071602
58appendage development (GO:0048736)2.57071602
59photoreceptor cell maintenance (GO:0045494)2.55943024
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55561971
61negative regulation of translation, ncRNA-mediated (GO:0040033)2.55561971
62regulation of translation, ncRNA-mediated (GO:0045974)2.55561971
63nonmotile primary cilium assembly (GO:0035058)2.54360272
64positive regulation of mitochondrial fission (GO:0090141)2.53349118
65startle response (GO:0001964)2.53144292
66microtubule depolymerization (GO:0007019)2.52562367
67L-fucose catabolic process (GO:0042355)2.50400602
68fucose catabolic process (GO:0019317)2.50400602
69L-fucose metabolic process (GO:0042354)2.50400602
70pyrimidine dimer repair (GO:0006290)2.48973538
71photoreceptor cell development (GO:0042461)2.47566867
72regulation of neurotransmitter uptake (GO:0051580)2.47381315
73regulation of centriole replication (GO:0046599)2.46794367
74rRNA catabolic process (GO:0016075)2.46494877
75piRNA metabolic process (GO:0034587)2.46223984
76cell differentiation in spinal cord (GO:0021515)2.44205023
77behavioral response to ethanol (GO:0048149)2.41925150
78dopamine transport (GO:0015872)2.40994474
79DNA demethylation (GO:0080111)2.40845134
80postreplication repair (GO:0006301)2.40818450
81mannosylation (GO:0097502)2.40765279
82protein localization to synapse (GO:0035418)2.40713270
83prenylation (GO:0097354)2.40211309
84protein prenylation (GO:0018342)2.40211309
85olfactory bulb development (GO:0021772)2.40122048
86forebrain neuron differentiation (GO:0021879)2.39401783
87indolalkylamine metabolic process (GO:0006586)2.38139991
88C4-dicarboxylate transport (GO:0015740)2.38123448
89retinal ganglion cell axon guidance (GO:0031290)2.37860978
90smoothened signaling pathway (GO:0007224)2.37723863
91DNA deamination (GO:0045006)2.36614470
92peptidyl-histidine modification (GO:0018202)2.36252521
93negative regulation of neurotransmitter transport (GO:0051589)2.36146041
94ubiquinone biosynthetic process (GO:0006744)2.35613614
95cellular ketone body metabolic process (GO:0046950)2.35337052
96synaptic transmission, cholinergic (GO:0007271)2.35097205
97DNA-dependent DNA replication (GO:0006261)2.33614266
98L-methionine salvage (GO:0071267)2.33335391
99L-methionine biosynthetic process (GO:0071265)2.33335391
100amino acid salvage (GO:0043102)2.33335391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.50577482
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36634719
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36265510
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.29251500
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.27266146
6IGF1R_20145208_ChIP-Seq_DFB_Human2.96353663
7GBX2_23144817_ChIP-Seq_PC3_Human2.93390680
8FUS_26573619_Chip-Seq_HEK293_Human2.92922467
9TAF15_26573619_Chip-Seq_HEK293_Human2.82716852
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71650300
11EWS_26573619_Chip-Seq_HEK293_Human2.61873756
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49956764
13VDR_22108803_ChIP-Seq_LS180_Human2.36638842
14EZH2_22144423_ChIP-Seq_EOC_Human2.36367291
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29215884
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19543446
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15941099
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10184323
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97906766
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95135497
21P300_19829295_ChIP-Seq_ESCs_Human1.91191458
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88080792
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.86938562
24ER_23166858_ChIP-Seq_MCF-7_Human1.85945271
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81331459
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.66779863
27AR_21572438_ChIP-Seq_LNCaP_Human1.65307670
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63544339
29STAT3_23295773_ChIP-Seq_U87_Human1.62775659
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58232524
31CBP_20019798_ChIP-Seq_JUKART_Human1.56819242
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56819242
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.56668120
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54803526
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54671274
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.53697695
37SMAD4_21799915_ChIP-Seq_A2780_Human1.49740740
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49667145
39IRF1_19129219_ChIP-ChIP_H3396_Human1.49466306
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42018066
41BCAT_22108803_ChIP-Seq_LS180_Human1.41485997
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40799128
43* TP53_22573176_ChIP-Seq_HFKS_Human1.40039751
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39658553
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38079283
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38079283
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36730785
48TCF4_23295773_ChIP-Seq_U87_Human1.35825257
49ELK1_19687146_ChIP-ChIP_HELA_Human1.35353819
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34044114
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33978221
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33608983
53MYC_18940864_ChIP-ChIP_HL60_Human1.33434282
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.32526343
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32270255
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30827378
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29497221
58AR_25329375_ChIP-Seq_VCAP_Human1.25788851
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.24845530
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24016295
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23983534
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23972664
63E2F7_22180533_ChIP-Seq_HELA_Human1.23603045
64RNF2_27304074_Chip-Seq_NSC_Mouse1.21184394
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.20929163
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20795663
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20011341
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.19603225
69REST_21632747_ChIP-Seq_MESCs_Mouse1.15924037
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14830270
71TCF4_22108803_ChIP-Seq_LS180_Human1.14293320
72* VDR_23849224_ChIP-Seq_CD4+_Human1.11933932
73RUNX2_22187159_ChIP-Seq_PCA_Human1.10566071
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10261302
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09600343
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08289433
77* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06937369
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.05584200
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03920652
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.03415318
81TP53_16413492_ChIP-PET_HCT116_Human1.01556147
82NANOG_19829295_ChIP-Seq_ESCs_Human0.99705848
83SOX2_19829295_ChIP-Seq_ESCs_Human0.99705848
84BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99117695
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97618131
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.97329811
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97060469
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.96451344
89SOX9_26525672_Chip-Seq_HEART_Mouse0.96424833
90P53_22387025_ChIP-Seq_ESCs_Mouse0.94380427
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.94202612
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.93763703
93E2F1_18555785_Chip-Seq_ESCs_Mouse0.93294954
94JUN_21703547_ChIP-Seq_K562_Human0.92886295
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.91824506
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90375341
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89711279
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86981351
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86831943
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.85058174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.79755657
2MP0005171_absent_coat_pigmentation3.21057772
3MP0008877_abnormal_DNA_methylation3.20891316
4MP0008057_abnormal_DNA_replication2.94872253
5MP0002102_abnormal_ear_morphology2.65533302
6MP0002638_abnormal_pupillary_reflex2.43672856
7MP0005174_abnormal_tail_pigmentation2.20533463
8MP0001968_abnormal_touch/_nociception2.18995778
9MP0003787_abnormal_imprinting2.13036143
10MP0003880_abnormal_central_pattern2.09262753
11MP0005645_abnormal_hypothalamus_physiol2.09161427
12MP0000569_abnormal_digit_pigmentation2.07062069
13MP0005423_abnormal_somatic_nervous2.02826196
14MP0005646_abnormal_pituitary_gland1.96918232
15MP0001986_abnormal_taste_sensitivity1.94403390
16MP0005551_abnormal_eye_electrophysiolog1.93213296
17MP0002736_abnormal_nociception_after1.83273174
18MP0001188_hyperpigmentation1.82917521
19MP0002653_abnormal_ependyma_morphology1.79654951
20MP0010094_abnormal_chromosome_stability1.75766880
21MP0009046_muscle_twitch1.73747869
22MP0001529_abnormal_vocalization1.69141057
23MP0000631_abnormal_neuroendocrine_gland1.68947835
24MP0005253_abnormal_eye_physiology1.68696137
25MP0006072_abnormal_retinal_apoptosis1.67133142
26MP0006292_abnormal_olfactory_placode1.66287948
27MP0000372_irregular_coat_pigmentation1.58001929
28MP0008058_abnormal_DNA_repair1.56786963
29MP0003121_genomic_imprinting1.53752328
30MP0000778_abnormal_nervous_system1.51661195
31MP0006276_abnormal_autonomic_nervous1.45744234
32MP0002938_white_spotting1.42876319
33MP0000383_abnormal_hair_follicle1.41125739
34MP0004142_abnormal_muscle_tone1.39599267
35MP0000427_abnormal_hair_cycle1.38401388
36MP0002735_abnormal_chemical_nociception1.37664895
37MP0001984_abnormal_olfaction1.35029708
38MP0009745_abnormal_behavioral_response1.34780301
39MP0008789_abnormal_olfactory_epithelium1.30323428
40MP0004133_heterotaxia1.29450027
41MP0002095_abnormal_skin_pigmentation1.28918220
42MP0001486_abnormal_startle_reflex1.28749784
43MP0003122_maternal_imprinting1.25885450
44MP0002751_abnormal_autonomic_nervous1.25816936
45MP0003195_calcinosis1.25225958
46MP0004043_abnormal_pH_regulation1.24924586
47MP0005187_abnormal_penis_morphology1.23414254
48MP0001293_anophthalmia1.22864921
49MP0004145_abnormal_muscle_electrophysio1.21946963
50MP0002928_abnormal_bile_duct1.20824782
51MP0002272_abnormal_nervous_system1.18565704
52MP0005499_abnormal_olfactory_system1.14469764
53MP0005394_taste/olfaction_phenotype1.14469764
54MP0002837_dystrophic_cardiac_calcinosis1.12475576
55MP0004215_abnormal_myocardial_fiber1.11373845
56MP0004885_abnormal_endolymph1.10806325
57MP0002822_catalepsy1.10424969
58MP0002557_abnormal_social/conspecific_i1.09098684
59MP0003635_abnormal_synaptic_transmissio1.07652866
60MP0004147_increased_porphyrin_level1.07356952
61MP0000647_abnormal_sebaceous_gland1.06532227
62MP0003937_abnormal_limbs/digits/tail_de1.05372706
63MP0002067_abnormal_sensory_capabilities1.01101727
64MP0002572_abnormal_emotion/affect_behav0.98829113
65MP0002064_seizures0.98790358
66MP0001485_abnormal_pinna_reflex0.98694683
67MP0000015_abnormal_ear_pigmentation0.98283313
68MP0002063_abnormal_learning/memory/cond0.97219414
69MP0005391_vision/eye_phenotype0.93934206
70MP0002160_abnormal_reproductive_system0.92661644
71MP0004742_abnormal_vestibular_system0.92025760
72MP0000955_abnormal_spinal_cord0.91094502
73MP0002752_abnormal_somatic_nervous0.90339609
74MP0003698_abnormal_male_reproductive0.90337009
75MP0001324_abnormal_eye_pigmentation0.89646269
76MP0000026_abnormal_inner_ear0.88860645
77MP0005386_behavior/neurological_phenoty0.86911373
78MP0004924_abnormal_behavior0.86911373
79MP0005195_abnormal_posterior_eye0.86795326
80MP0002210_abnormal_sex_determination0.86745218
81MP0003646_muscle_fatigue0.86613841
82MP0003718_maternal_effect0.86440153
83MP0002184_abnormal_innervation0.85760681
84MP0001929_abnormal_gametogenesis0.83848830
85MP0000049_abnormal_middle_ear0.83782207
86MP0001970_abnormal_pain_threshold0.83392092
87MP0001919_abnormal_reproductive_system0.82767405
88MP0005389_reproductive_system_phenotype0.82640062
89MP0002009_preneoplasia0.82619605
90MP0002734_abnormal_mechanical_nocicepti0.81924293
91MP0003693_abnormal_embryo_hatching0.81640318
92MP0008875_abnormal_xenobiotic_pharmacok0.81233422
93MP0001286_abnormal_eye_development0.79777023
94MP0002233_abnormal_nose_morphology0.78792202
95MP0003111_abnormal_nucleus_morphology0.78446056
96MP0002882_abnormal_neuron_morphology0.78386312
97MP0008872_abnormal_physiological_respon0.77372453
98MP0003119_abnormal_digestive_system0.76248784
99MP0003567_abnormal_fetal_cardiomyocyte0.75602390
100MP0003077_abnormal_cell_cycle0.75460588

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.81368144
2Pancreatic fibrosis (HP:0100732)3.62136009
3True hermaphroditism (HP:0010459)3.52968482
4Abnormality of midbrain morphology (HP:0002418)3.46650416
5Molar tooth sign on MRI (HP:0002419)3.46650416
6Chronic hepatic failure (HP:0100626)3.40499805
7Nephronophthisis (HP:0000090)3.16374567
8Hyperventilation (HP:0002883)3.11861159
9Type II lissencephaly (HP:0007260)3.03665987
10Cerebellar dysplasia (HP:0007033)3.02429314
11Abnormality of the renal medulla (HP:0100957)2.92327083
12Medial flaring of the eyebrow (HP:0010747)2.87985230
13Congenital stationary night blindness (HP:0007642)2.81099721
14Abnormality of the renal cortex (HP:0011035)2.79781628
15Rib fusion (HP:0000902)2.77013011
16Lissencephaly (HP:0001339)2.72669625
17Patellar aplasia (HP:0006443)2.65192613
18Tubular atrophy (HP:0000092)2.52939429
19Cystic liver disease (HP:0006706)2.52422886
20Renal cortical cysts (HP:0000803)2.46185302
21Volvulus (HP:0002580)2.44415824
22Gait imbalance (HP:0002141)2.43751325
23Aplasia/Hypoplasia of the patella (HP:0006498)2.40909764
24Postaxial foot polydactyly (HP:0001830)2.39807327
25Congenital primary aphakia (HP:0007707)2.38433467
26Attenuation of retinal blood vessels (HP:0007843)2.37115304
27Tubulointerstitial nephritis (HP:0001970)2.32540836
28Nephrogenic diabetes insipidus (HP:0009806)2.31609999
29Oligodactyly (hands) (HP:0001180)2.30876380
30Optic nerve hypoplasia (HP:0000609)2.28143189
31Gaze-evoked nystagmus (HP:0000640)2.25710489
32Glioma (HP:0009733)2.25087971
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.22501313
34Chorioretinal atrophy (HP:0000533)2.21553956
35Genital tract atresia (HP:0001827)2.20794935
36Congenital hepatic fibrosis (HP:0002612)2.20219885
37Colon cancer (HP:0003003)2.19908860
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.18535970
39Protruding tongue (HP:0010808)2.16996191
40Small hand (HP:0200055)2.16263210
41Retinal dysplasia (HP:0007973)2.11381869
42Vaginal atresia (HP:0000148)2.08854807
43Sclerocornea (HP:0000647)2.07740231
44Absent speech (HP:0001344)2.07703014
45Focal motor seizures (HP:0011153)2.06703532
46Preaxial hand polydactyly (HP:0001177)2.06364762
47Astrocytoma (HP:0009592)2.06028403
48Abnormality of the astrocytes (HP:0100707)2.06028403
49Birth length less than 3rd percentile (HP:0003561)2.04419721
50Occipital encephalocele (HP:0002085)2.04179937
51Pachygyria (HP:0001302)2.02321147
52Polydipsia (HP:0001959)2.00950471
53Abnormal drinking behavior (HP:0030082)2.00950471
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99934317
55Broad-based gait (HP:0002136)1.98839180
56Postaxial hand polydactyly (HP:0001162)1.97015932
57Aplasia/Hypoplasia of the uvula (HP:0010293)1.95854103
58Bony spicule pigmentary retinopathy (HP:0007737)1.94335161
59Hypoplasia of the pons (HP:0012110)1.93910454
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93122943
61Abnormality of alanine metabolism (HP:0010916)1.93122943
62Hyperalaninemia (HP:0003348)1.93122943
63Abnormality of the pons (HP:0007361)1.92961597
64Abnormality of chromosome stability (HP:0003220)1.92116594
65Poor coordination (HP:0002370)1.89311258
66Dandy-Walker malformation (HP:0001305)1.88119593
67Inability to walk (HP:0002540)1.87415214
68Abnormal biliary tract physiology (HP:0012439)1.87248444
69Bile duct proliferation (HP:0001408)1.87248444
70Anencephaly (HP:0002323)1.84113397
71Ectopic kidney (HP:0000086)1.83914610
72Short tibia (HP:0005736)1.83786574
73Pendular nystagmus (HP:0012043)1.81760627
74Genetic anticipation (HP:0003743)1.81378857
75Septo-optic dysplasia (HP:0100842)1.81198812
76Male pseudohermaphroditism (HP:0000037)1.80575054
77Abnormality of the ileum (HP:0001549)1.80330505
78Drooling (HP:0002307)1.79994395
79Keratoconus (HP:0000563)1.79938236
80Increased corneal curvature (HP:0100692)1.79938236
81Sloping forehead (HP:0000340)1.79887856
82Abnormal respiratory epithelium morphology (HP:0012253)1.79808027
83Abnormal respiratory motile cilium morphology (HP:0005938)1.79808027
84Short foot (HP:0001773)1.78713882
85Meckel diverticulum (HP:0002245)1.78616305
86Progressive cerebellar ataxia (HP:0002073)1.75330296
87Chromsome breakage (HP:0040012)1.75169522
88Progressive inability to walk (HP:0002505)1.73592488
89Astigmatism (HP:0000483)1.73043150
90Ependymoma (HP:0002888)1.72775424
91Tented upper lip vermilion (HP:0010804)1.72701514
92Oligodactyly (HP:0012165)1.72283503
93Hemiparesis (HP:0001269)1.69432115
94Median cleft lip (HP:0000161)1.68525112
95Hypoalbuminemia (HP:0003073)1.67877844
96Abnormal albumin level (HP:0012116)1.67877844
97Abolished electroretinogram (ERG) (HP:0000550)1.67587426
98Narrow forehead (HP:0000341)1.67415728
99Stomach cancer (HP:0012126)1.66957039
100Prominent nasal bridge (HP:0000426)1.66507312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.65874757
2WNK33.06317557
3CASK3.05346661
4BMPR1B2.75844375
5MAP3K42.49475047
6ZAK2.47846299
7WNK42.20524104
8MAP4K22.10413923
9NUAK12.02182518
10MAPK131.79479226
11ADRBK21.75223520
12INSRR1.75074606
13BCR1.74837965
14TNIK1.74757770
15MKNK21.69168413
16MAP2K71.61609272
17PINK11.57427465
18CDC71.57309202
19MARK11.55881604
20ACVR1B1.49715125
21MAPK151.44309902
22PLK21.44221017
23CAMKK21.35390774
24ATR1.33998083
25TRIM281.31404420
26SRPK11.29172960
27DYRK21.27347790
28ERBB31.22906268
29MKNK11.20523057
30TLK11.20232165
31PNCK1.18221099
32STK391.12305986
33PLK41.10453633
34FGFR21.09616201
35GRK11.01855832
36BRSK21.00880557
37CSNK1G11.00733138
38CSNK1A1L0.99886103
39CSNK1G30.99598456
40CSNK1G20.99352428
41DYRK30.98904284
42WEE10.98563101
43NTRK20.98154162
44STK38L0.96271244
45OBSCN0.94034722
46RPS6KA40.93623432
47CCNB10.92025907
48NEK10.91859661
49CDK30.91061132
50AKT30.90072447
51OXSR10.87227280
52PAK30.84787977
53SIK20.83876773
54PLK30.82059504
55SGK20.80639961
56PRKCE0.78910209
57TGFBR10.78794099
58ATM0.77588722
59CHEK20.75163929
60CAMK40.73232350
61MUSK0.72969486
62PLK10.71981595
63TSSK60.70808339
64VRK10.69471919
65FER0.68221772
66CSNK1A10.66359998
67PRKCG0.65919446
68SGK2230.65610690
69SGK4940.65610690
70EPHA40.65067771
71NEK20.64894130
72IRAK10.64675795
73RPS6KA50.63652572
74TAOK30.61263043
75ADRBK10.59964787
76CSNK1D0.59343300
77TXK0.57617842
78LATS10.56518032
79CAMK10.56514430
80CAMK1G0.52361242
81TYRO30.49881109
82NTRK30.49638475
83EIF2AK30.45685991
84CAMK2A0.45550642
85FLT30.45455586
86PRKAA10.43498277
87WNK10.42530573
88DYRK1A0.41846911
89PKN10.41563554
90BRD40.41227661
91STK110.40899200
92FGFR10.39947905
93MAP2K40.39901098
94PRKACB0.39209509
95PIK3CA0.38043588
96PRKACA0.37410727
97PHKG20.37191900
98PHKG10.37191900
99PRKDC0.35952841
100UHMK10.35894066

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.47460318
2Fanconi anemia pathway_Homo sapiens_hsa034603.33360025
3Homologous recombination_Homo sapiens_hsa034402.80175363
4Non-homologous end-joining_Homo sapiens_hsa034502.68310999
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.63505847
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53902697
7Nicotine addiction_Homo sapiens_hsa050332.33127189
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.29894614
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15754820
10Phototransduction_Homo sapiens_hsa047442.12504743
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03146594
12Basal transcription factors_Homo sapiens_hsa030221.91778876
13Taste transduction_Homo sapiens_hsa047421.87970283
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85572201
15Butanoate metabolism_Homo sapiens_hsa006501.80959790
16Nitrogen metabolism_Homo sapiens_hsa009101.76792513
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69080324
18Selenocompound metabolism_Homo sapiens_hsa004501.64422162
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62799584
20RNA polymerase_Homo sapiens_hsa030201.59004407
21RNA degradation_Homo sapiens_hsa030181.54965676
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52146742
23One carbon pool by folate_Homo sapiens_hsa006701.44800968
24Steroid biosynthesis_Homo sapiens_hsa001001.39276205
25Propanoate metabolism_Homo sapiens_hsa006401.32487049
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31094594
27Linoleic acid metabolism_Homo sapiens_hsa005911.30117145
28Morphine addiction_Homo sapiens_hsa050321.29595759
29Protein export_Homo sapiens_hsa030601.27329174
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25839474
31Hedgehog signaling pathway_Homo sapiens_hsa043401.20575413
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20468391
33Mismatch repair_Homo sapiens_hsa034301.20059090
34Cocaine addiction_Homo sapiens_hsa050301.19558731
35Ether lipid metabolism_Homo sapiens_hsa005651.15449468
36GABAergic synapse_Homo sapiens_hsa047271.15180489
37Base excision repair_Homo sapiens_hsa034101.12444293
38RNA transport_Homo sapiens_hsa030131.12281312
39Alcoholism_Homo sapiens_hsa050341.08627816
40Basal cell carcinoma_Homo sapiens_hsa052171.08248387
41Lysine degradation_Homo sapiens_hsa003101.05987436
42Circadian rhythm_Homo sapiens_hsa047101.04559379
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.03195318
44Olfactory transduction_Homo sapiens_hsa047401.00713574
45Peroxisome_Homo sapiens_hsa041461.00645182
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99785211
47Glutamatergic synapse_Homo sapiens_hsa047240.97577119
48Nucleotide excision repair_Homo sapiens_hsa034200.96460919
49ABC transporters_Homo sapiens_hsa020100.95933621
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94878234
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93143761
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89273666
53Hippo signaling pathway_Homo sapiens_hsa043900.89209791
54Circadian entrainment_Homo sapiens_hsa047130.87708333
55Tryptophan metabolism_Homo sapiens_hsa003800.84785545
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83109095
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82483163
58Pyrimidine metabolism_Homo sapiens_hsa002400.80793101
59Sulfur relay system_Homo sapiens_hsa041220.80746921
60Purine metabolism_Homo sapiens_hsa002300.80425760
61Cell cycle_Homo sapiens_hsa041100.79737304
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.76396239
63Regulation of autophagy_Homo sapiens_hsa041400.75687076
64Calcium signaling pathway_Homo sapiens_hsa040200.71101331
65Caffeine metabolism_Homo sapiens_hsa002320.70992709
66Amphetamine addiction_Homo sapiens_hsa050310.69102737
67Spliceosome_Homo sapiens_hsa030400.68772768
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68658551
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.66503500
70Systemic lupus erythematosus_Homo sapiens_hsa053220.66207568
71TGF-beta signaling pathway_Homo sapiens_hsa043500.64206634
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64117838
73Parkinsons disease_Homo sapiens_hsa050120.63438583
74DNA replication_Homo sapiens_hsa030300.62579799
75Oxidative phosphorylation_Homo sapiens_hsa001900.61308497
76mRNA surveillance pathway_Homo sapiens_hsa030150.59410169
77Dopaminergic synapse_Homo sapiens_hsa047280.59201491
78Serotonergic synapse_Homo sapiens_hsa047260.58997356
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58895754
80Axon guidance_Homo sapiens_hsa043600.57785675
81Glycerolipid metabolism_Homo sapiens_hsa005610.55814803
82Huntingtons disease_Homo sapiens_hsa050160.55436666
83Insulin secretion_Homo sapiens_hsa049110.54583251
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.52968040
85Cholinergic synapse_Homo sapiens_hsa047250.50950879
86Ovarian steroidogenesis_Homo sapiens_hsa049130.49817223
87Oocyte meiosis_Homo sapiens_hsa041140.47844891
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45912557
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45545439
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45095812
91Metabolic pathways_Homo sapiens_hsa011000.43969614
92Fatty acid metabolism_Homo sapiens_hsa012120.43461112
93beta-Alanine metabolism_Homo sapiens_hsa004100.42102153
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39754833
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39246998
96Vitamin B6 metabolism_Homo sapiens_hsa007500.37775405
97Fatty acid degradation_Homo sapiens_hsa000710.35409234
98Wnt signaling pathway_Homo sapiens_hsa043100.35032039
99p53 signaling pathway_Homo sapiens_hsa041150.34154897
100Primary immunodeficiency_Homo sapiens_hsa053400.34153681

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