ZNF587B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)4.96887386
2nuclear pore complex assembly (GO:0051292)4.73517226
3regulation of mitotic spindle checkpoint (GO:1903504)4.68063634
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.68063634
5negative regulation of DNA-dependent DNA replication (GO:2000104)4.51724716
6nuclear pore organization (GO:0006999)4.48152495
7DNA double-strand break processing (GO:0000729)4.44577562
8chromatin remodeling at centromere (GO:0031055)4.42137207
9CENP-A containing nucleosome assembly (GO:0034080)4.24530261
10negative regulation of translation, ncRNA-mediated (GO:0040033)4.22315667
11regulation of translation, ncRNA-mediated (GO:0045974)4.22315667
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.22315667
13histone exchange (GO:0043486)4.08346844
14somatic hypermutation of immunoglobulin genes (GO:0016446)4.07915859
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.07915859
16DNA replication checkpoint (GO:0000076)4.02840370
17regulation of centriole replication (GO:0046599)3.92159670
18non-recombinational repair (GO:0000726)3.89787639
19double-strand break repair via nonhomologous end joining (GO:0006303)3.89787639
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.83988714
21IMP biosynthetic process (GO:0006188)3.80865573
22RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.78505417
23regulation of posttranscriptional gene silencing (GO:0060147)3.76966277
24regulation of gene silencing by miRNA (GO:0060964)3.76966277
25regulation of gene silencing by RNA (GO:0060966)3.76966277
26protein localization to kinetochore (GO:0034501)3.76732697
27ribosome assembly (GO:0042255)3.74356863
28mitotic nuclear envelope disassembly (GO:0007077)3.74221192
29pre-miRNA processing (GO:0031054)3.73019135
30spindle checkpoint (GO:0031577)3.70198512
31replication fork processing (GO:0031297)3.67810295
32mitotic sister chromatid cohesion (GO:0007064)3.67320424
33isotype switching (GO:0045190)3.64358937
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.64358937
35somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.64358937
36negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.62864989
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.62864989
38negative regulation of mitotic sister chromatid segregation (GO:0033048)3.62864989
39negative regulation of mitotic sister chromatid separation (GO:2000816)3.62864989
40negative regulation of sister chromatid segregation (GO:0033046)3.62864989
41DNA replication-dependent nucleosome organization (GO:0034723)3.62611549
42DNA replication-dependent nucleosome assembly (GO:0006335)3.62611549
43mitotic spindle checkpoint (GO:0071174)3.62557049
44DNA strand elongation involved in DNA replication (GO:0006271)3.60304319
45negative regulation of chromosome segregation (GO:0051985)3.59918990
46pore complex assembly (GO:0046931)3.59589449
47proteasome assembly (GO:0043248)3.59490931
48DNA replication-independent nucleosome organization (GO:0034724)3.56198660
49DNA replication-independent nucleosome assembly (GO:0006336)3.56198660
50regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.50054634
51regulation of mitotic metaphase/anaphase transition (GO:0030071)3.50054634
52membrane disassembly (GO:0030397)3.45999042
53nuclear envelope disassembly (GO:0051081)3.45999042
54mitotic metaphase plate congression (GO:0007080)3.41284929
55purine nucleobase biosynthetic process (GO:0009113)3.39747384
56somatic recombination of immunoglobulin gene segments (GO:0016447)3.38977030
57regulation of mitotic sister chromatid separation (GO:0010965)3.37760357
58regulation of mitotic sister chromatid segregation (GO:0033047)3.37760357
59regulation of sister chromatid segregation (GO:0033045)3.37760357
60DNA strand elongation (GO:0022616)3.37626828
61negative regulation of DNA recombination (GO:0045910)3.37239715
62establishment of integrated proviral latency (GO:0075713)3.33537719
63response to X-ray (GO:0010165)3.32365398
64regulation of helicase activity (GO:0051095)3.31041285
65nucleobase biosynthetic process (GO:0046112)3.28913542
66IMP metabolic process (GO:0046040)3.28716937
67mitotic spindle assembly checkpoint (GO:0007094)3.28642584
68regulation of DNA endoreduplication (GO:0032875)3.27893996
69somatic diversification of immunoglobulins (GO:0016445)3.26877079
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.26867367
71metaphase plate congression (GO:0051310)3.24546593
72spindle assembly checkpoint (GO:0071173)3.22133378
73lactate metabolic process (GO:0006089)3.15544472
74DNA catabolic process, exonucleolytic (GO:0000738)3.14791214
75regulation of histone H3-K9 methylation (GO:0051570)3.14079161
76regulation of chromosome segregation (GO:0051983)3.09402329
77DNA replication initiation (GO:0006270)3.08772026
78somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.07520893
79somatic cell DNA recombination (GO:0016444)3.07520893
80maturation of 5.8S rRNA (GO:0000460)3.06571025
81somatic diversification of immune receptors (GO:0002200)3.01403384
82DNA geometric change (GO:0032392)3.00353341
83telomere maintenance via semi-conservative replication (GO:0032201)2.99179535
84regulation of centrosome cycle (GO:0046605)2.99016303
85mitotic recombination (GO:0006312)2.98878503
86telomere maintenance via recombination (GO:0000722)2.97407780
87DNA ligation (GO:0006266)2.96626417
88DNA duplex unwinding (GO:0032508)2.92584484
89single strand break repair (GO:0000012)2.92503144
90ncRNA catabolic process (GO:0034661)2.92464891
91double-strand break repair via homologous recombination (GO:0000724)2.92451378
92positive regulation of chromosome segregation (GO:0051984)2.92263667
93recombinational repair (GO:0000725)2.91966034
94regulation of centrosome duplication (GO:0010824)2.91787290
95regulation of spindle checkpoint (GO:0090231)2.90666770
96mitochondrial RNA metabolic process (GO:0000959)2.88853472
97postreplication repair (GO:0006301)2.88723750
98positive regulation of histone H3-K4 methylation (GO:0051571)2.88136584
99protein prenylation (GO:0018342)2.84548857
100prenylation (GO:0097354)2.84548857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79001960
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90534075
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.43179150
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14978154
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00961891
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.74561038
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.66303992
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.53980965
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50627990
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41957162
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39522409
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.37562242
13ELK1_19687146_ChIP-ChIP_HELA_Human2.33246002
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.29388132
15ZNF274_21170338_ChIP-Seq_K562_Hela2.25193526
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19982631
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10313194
18EWS_26573619_Chip-Seq_HEK293_Human2.06023382
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96071847
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89697152
21VDR_23849224_ChIP-Seq_CD4+_Human1.87564941
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86327277
23FUS_26573619_Chip-Seq_HEK293_Human1.85419289
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.83110151
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.82065078
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80491063
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78703875
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72894277
29FOXP3_21729870_ChIP-Seq_TREG_Human1.66980244
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66692670
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66460760
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61436658
33VDR_22108803_ChIP-Seq_LS180_Human1.60952093
34AR_21909140_ChIP-Seq_LNCAP_Human1.59307483
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.56199337
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54883160
37P300_19829295_ChIP-Seq_ESCs_Human1.54088210
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53632907
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49329008
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42861697
41TAF15_26573619_Chip-Seq_HEK293_Human1.41978713
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39169458
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38304393
44MYC_18940864_ChIP-ChIP_HL60_Human1.36655559
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33738380
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30916194
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28337872
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.27637180
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27406837
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.24017048
51IGF1R_20145208_ChIP-Seq_DFB_Human1.23533047
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.22270498
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21147784
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20760666
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18597347
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16281743
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16015635
58IRF1_19129219_ChIP-ChIP_H3396_Human1.12204201
59ER_23166858_ChIP-Seq_MCF-7_Human1.11726649
60GBX2_23144817_ChIP-Seq_PC3_Human1.10660229
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07521110
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04627820
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.04602293
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01982830
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.00900251
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98136221
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95848635
68SRF_21415370_ChIP-Seq_HL-1_Mouse0.95380857
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94848745
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94848745
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94755174
72CBP_20019798_ChIP-Seq_JUKART_Human0.94755174
73STAT3_23295773_ChIP-Seq_U87_Human0.93613538
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93598404
75KDM5A_27292631_Chip-Seq_BREAST_Human0.93115793
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92034231
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91191490
78GABP_19822575_ChIP-Seq_HepG2_Human0.90556577
79P300_18555785_Chip-Seq_ESCs_Mouse0.89016693
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88604568
81CRX_20693478_ChIP-Seq_RETINA_Mouse0.88522367
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88450096
83PIAS1_25552417_ChIP-Seq_VCAP_Human0.88268737
84TCF4_23295773_ChIP-Seq_U87_Human0.88142746
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87884076
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87392668
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86427393
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86132283
89TTF2_22483619_ChIP-Seq_HELA_Human0.85466455
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.85395737
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84958459
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84798300
93SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84642010
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.84398030
95E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83951306
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83802035
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83802035
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83802035
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80070929
100CDX2_22108803_ChIP-Seq_LS180_Human0.79726980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.45820093
2MP0010094_abnormal_chromosome_stability4.49749300
3MP0008058_abnormal_DNA_repair4.02304811
4MP0008877_abnormal_DNA_methylation3.89336908
5MP0003693_abnormal_embryo_hatching3.76980054
6MP0003111_abnormal_nucleus_morphology3.52795495
7MP0003890_abnormal_embryonic-extraembry3.23744580
8MP0004957_abnormal_blastocyst_morpholog3.14732554
9MP0003941_abnormal_skin_development2.87100384
10MP0003077_abnormal_cell_cycle2.78814629
11MP0003718_maternal_effect2.75331579
12MP0002254_reproductive_system_inflammat2.61732631
13MP0002102_abnormal_ear_morphology2.49890599
14MP0008007_abnormal_cellular_replicative2.26363658
15MP0010307_abnormal_tumor_latency2.17073597
16MP0000372_irregular_coat_pigmentation2.13108051
17MP0008932_abnormal_embryonic_tissue1.94305238
18MP0010352_gastrointestinal_tract_polyps1.88617045
19MP0003786_premature_aging1.87046468
20MP0009697_abnormal_copulation1.81379862
21MP0002396_abnormal_hematopoietic_system1.80438398
22MP0005075_abnormal_melanosome_morpholog1.62492233
23MP0003646_muscle_fatigue1.62287612
24MP0003787_abnormal_imprinting1.53668741
25MP0001730_embryonic_growth_arrest1.51827787
26MP0003567_abnormal_fetal_cardiomyocyte1.48001289
27MP0001293_anophthalmia1.47452399
28MP0009672_abnormal_birth_weight1.43118995
29MP0006292_abnormal_olfactory_placode1.41442533
30MP0000350_abnormal_cell_proliferation1.39227269
31MP0003195_calcinosis1.38367558
32MP0003937_abnormal_limbs/digits/tail_de1.38220920
33MP0005395_other_phenotype1.34758551
34MP0003121_genomic_imprinting1.33849275
35MP0005380_embryogenesis_phenotype1.31190612
36MP0001672_abnormal_embryogenesis/_devel1.31190612
37MP0003136_yellow_coat_color1.23678042
38MP0002006_tumorigenesis1.23444698
39MP0009703_decreased_birth_body1.21580415
40MP0001697_abnormal_embryo_size1.19195322
41MP0002166_altered_tumor_susceptibility1.18928761
42MP0000427_abnormal_hair_cycle1.17919698
43MP0001929_abnormal_gametogenesis1.16712606
44MP0002084_abnormal_developmental_patter1.15585617
45MP0001485_abnormal_pinna_reflex1.14033834
46MP0002088_abnormal_embryonic_growth/wei1.14022856
47MP0003119_abnormal_digestive_system1.12636467
48MP0003984_embryonic_growth_retardation1.10588353
49MP0000569_abnormal_digit_pigmentation1.09550186
50MP0002009_preneoplasia1.09187407
51MP0002085_abnormal_embryonic_tissue1.06979723
52MP0004197_abnormal_fetal_growth/weight/1.02550164
53MP0001188_hyperpigmentation1.00594760
54MP0004133_heterotaxia1.00487619
55MP0002938_white_spotting1.00381929
56MP0000383_abnormal_hair_follicle0.99039974
57MP0002210_abnormal_sex_determination0.97012451
58MP0006072_abnormal_retinal_apoptosis0.93972677
59MP0005377_hearing/vestibular/ear_phenot0.93494128
60MP0003878_abnormal_ear_physiology0.93494128
61MP0002080_prenatal_lethality0.93113240
62MP0001119_abnormal_female_reproductive0.92909994
63MP0005220_abnormal_exocrine_pancreas0.92847647
64MP0002086_abnormal_extraembryonic_tissu0.92074250
65MP0002019_abnormal_tumor_incidence0.90815140
66MP0000653_abnormal_sex_gland0.89370208
67MP0001286_abnormal_eye_development0.88415374
68MP0008995_early_reproductive_senescence0.88164959
69MP0004808_abnormal_hematopoietic_stem0.88096795
70MP0001145_abnormal_male_reproductive0.86187356
71MP0004381_abnormal_hair_follicle0.84678634
72MP0010678_abnormal_skin_adnexa0.80968910
73MP0000313_abnormal_cell_death0.80495585
74MP0002751_abnormal_autonomic_nervous0.78168814
75MP0006035_abnormal_mitochondrial_morpho0.78062913
76MP0000516_abnormal_urinary_system0.77019934
77MP0005367_renal/urinary_system_phenotyp0.77019934
78MP0001661_extended_life_span0.74738653
79MP0005408_hypopigmentation0.74442582
80MP0005253_abnormal_eye_physiology0.74134627
81MP0000647_abnormal_sebaceous_gland0.73234553
82MP0005174_abnormal_tail_pigmentation0.73032223
83MP0003221_abnormal_cardiomyocyte_apopto0.71996549
84MP0001324_abnormal_eye_pigmentation0.71483405
85MP0005551_abnormal_eye_electrophysiolog0.70373883
86MP0000015_abnormal_ear_pigmentation0.69577496
87MP0003698_abnormal_male_reproductive0.69484619
88MP0002095_abnormal_skin_pigmentation0.67566122
89MP0003699_abnormal_female_reproductive0.64738152
90MP0002138_abnormal_hepatobiliary_system0.64059425
91MP0005410_abnormal_fertilization0.62950679
92MP0000371_diluted_coat_color0.62340198
93MP0000631_abnormal_neuroendocrine_gland0.61735054
94MP0002111_abnormal_tail_morphology0.61608540
95MP0002090_abnormal_vision0.61223504
96MP0002697_abnormal_eye_size0.60414977
97MP0003943_abnormal_hepatobiliary_system0.60054287
98MP0005647_abnormal_sex_gland0.59931399
99MP0000703_abnormal_thymus_morphology0.59781646
100MP0001177_atelectasis0.59506713

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46237632
2Chromsome breakage (HP:0040012)4.08720060
3Colon cancer (HP:0003003)3.93543792
4Birth length less than 3rd percentile (HP:0003561)3.90372026
5Abnormality of the labia minora (HP:0012880)3.79499872
6Abnormality of chromosome stability (HP:0003220)3.68907428
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.25571010
8Ependymoma (HP:0002888)3.12379583
9Nephroblastoma (Wilms tumor) (HP:0002667)3.12104211
10Meckel diverticulum (HP:0002245)3.10345933
11Abnormality of the ileum (HP:0001549)3.09631405
12Abnormality of the preputium (HP:0100587)3.04334689
13Clubbing of toes (HP:0100760)3.02301783
14Embryonal renal neoplasm (HP:0011794)2.94784185
15Neoplasm of the adrenal cortex (HP:0100641)2.92388842
16Volvulus (HP:0002580)2.90338272
17Glioma (HP:0009733)2.63304516
18Rhabdomyosarcoma (HP:0002859)2.62795110
19Neoplasm of the adrenal gland (HP:0100631)2.60857659
20Sloping forehead (HP:0000340)2.55949029
21Small intestinal stenosis (HP:0012848)2.51234381
22Duodenal stenosis (HP:0100867)2.51234381
23Ectopic kidney (HP:0000086)2.32051509
24Astrocytoma (HP:0009592)2.31927179
25Abnormality of the astrocytes (HP:0100707)2.31927179
26Abnormality of the pons (HP:0007361)2.31798299
27Abnormality of the duodenum (HP:0002246)2.27189279
28Abnormal lung lobation (HP:0002101)2.27109370
29Myelodysplasia (HP:0002863)2.25281268
30Biliary tract neoplasm (HP:0100574)2.23764845
31Hypoplasia of the pons (HP:0012110)2.21353972
32Chronic otitis media (HP:0000389)2.16994281
33Abnormal hair whorl (HP:0010721)2.16877469
34Patellar aplasia (HP:0006443)2.12619208
35Homocystinuria (HP:0002156)2.08412016
36Abnormality of homocysteine metabolism (HP:0010919)2.08412016
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07756966
38Abnormality of alanine metabolism (HP:0010916)2.07479018
39Hyperalaninemia (HP:0003348)2.07479018
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07479018
41Progressive inability to walk (HP:0002505)2.07170828
42Abnormality of methionine metabolism (HP:0010901)2.07117136
43Medulloblastoma (HP:0002885)2.05941168
44Pancreatic islet-cell hyperplasia (HP:0004510)2.05070111
45Abnormality of serum amino acid levels (HP:0003112)2.05047703
46Neoplasm of the colon (HP:0100273)2.04637802
47Stomach cancer (HP:0012126)2.03504146
48Pancreatic cysts (HP:0001737)1.98135059
49Absent radius (HP:0003974)1.96396499
50Duplicated collecting system (HP:0000081)1.95063649
51Breast carcinoma (HP:0003002)1.92851555
52Acute myeloid leukemia (HP:0004808)1.92582924
53Clitoromegaly (HP:0000057)1.90149121
54Protruding tongue (HP:0010808)1.90122079
55Septo-optic dysplasia (HP:0100842)1.90093264
56Absent forearm bone (HP:0003953)1.87941555
57Aplasia involving forearm bones (HP:0009822)1.87941555
58Esophageal atresia (HP:0002032)1.87833815
59Prominent nose (HP:0000448)1.87099113
60Cellular immunodeficiency (HP:0005374)1.85032411
61Intestinal atresia (HP:0011100)1.84633440
62Methylmalonic acidemia (HP:0002912)1.84299636
63Aplasia/Hypoplasia of the patella (HP:0006498)1.83453243
64Agnosia (HP:0010524)1.81919061
65Fair hair (HP:0002286)1.81647875
66Abnormality of abdominal situs (HP:0011620)1.80460605
67Abdominal situs inversus (HP:0003363)1.80460605
68Cafe-au-lait spot (HP:0000957)1.79792752
69Type I transferrin isoform profile (HP:0003642)1.78867035
70Gastrointestinal atresia (HP:0002589)1.77187476
71Abnormality of the carotid arteries (HP:0005344)1.76759061
72Ovarian neoplasm (HP:0100615)1.76434119
73Aplasia/Hypoplasia of the sternum (HP:0006714)1.76128201
74Dandy-Walker malformation (HP:0001305)1.75713603
75Abnormality of DNA repair (HP:0003254)1.74449189
76Neoplasm of the small intestine (HP:0100833)1.73707140
77Neoplasm of striated muscle (HP:0009728)1.73544165
78Hyperglycinuria (HP:0003108)1.73450505
79Pancreatic fibrosis (HP:0100732)1.71769806
80Gaze-evoked nystagmus (HP:0000640)1.71367521
81Bilateral microphthalmos (HP:0007633)1.70727924
82Bifid tongue (HP:0010297)1.69598811
83Abnormality of the renal collecting system (HP:0004742)1.69539151
84Small hand (HP:0200055)1.68748311
85Hyperglycinemia (HP:0002154)1.67555674
86Abnormality of the parathyroid morphology (HP:0011766)1.66256196
87Embryonal neoplasm (HP:0002898)1.65605895
88Abnormality of the clitoris (HP:0000056)1.65281426
89Abnormality of the fingertips (HP:0001211)1.65056682
90Abnormality of serine family amino acid metabolism (HP:0010894)1.64945356
91Abnormality of glycine metabolism (HP:0010895)1.64945356
92IgM deficiency (HP:0002850)1.64218990
93Abnormality of midbrain morphology (HP:0002418)1.64031288
94Molar tooth sign on MRI (HP:0002419)1.64031288
95Abnormal biliary tract physiology (HP:0012439)1.63825471
96Bile duct proliferation (HP:0001408)1.63825471
97Chronic hepatic failure (HP:0100626)1.62927717
98Abnormal biliary tract morphology (HP:0012440)1.62015372
99Hypoplastic labia majora (HP:0000059)1.61174295
100Uterine neoplasm (HP:0010784)1.60828743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.77135455
2MKNK23.43652939
3TSSK63.24430947
4MST43.10118238
5NUAK13.07260219
6ZAK2.99555356
7ACVR1B2.96569326
8CDC72.86325231
9MKNK12.67775915
10TTK2.61767155
11WNK32.55146751
12BUB12.53820719
13TNIK2.45332939
14PLK32.34756296
15EIF2AK32.06495237
16BMPR1B2.05632374
17BRSK21.91184456
18PLK41.87337168
19SRPK11.85045766
20TRIM281.71769358
21PBK1.66381679
22TAF11.49752268
23NEK11.48822370
24AKT31.39469988
25NLK1.35096903
26PLK11.29745199
27ATR1.25163580
28WEE11.19425723
29PASK1.17885787
30VRK11.16271531
31EIF2AK21.16145690
32STK38L1.15922187
33EIF2AK11.14140486
34NME11.12009642
35CAMK1D1.07516274
36VRK21.06754929
37STK101.05217077
38ATM1.01721184
39CHEK21.00015290
40CASK0.99800717
41ALK0.97977784
42MAP4K20.97411383
43OXSR10.96037340
44GRK10.95023859
45TGFBR10.94605782
46CAMK1G0.90568507
47TEC0.89439937
48STK30.88919648
49INSRR0.87617506
50FGFR20.86186223
51CHEK10.85729387
52ERBB40.83482601
53MAP3K100.81573648
54LATS10.81026350
55PLK20.78378523
56MELK0.72708048
57TGFBR20.72447101
58FLT30.70868322
59BRD40.70531227
60NEK20.69336523
61AURKB0.67701133
62CSNK1G10.66221730
63FGFR10.65992948
64GRK70.65153143
65STK40.62131881
66MAP3K40.61738145
67STK390.61153882
68CDK120.59540469
69YES10.57342718
70ERBB30.52993305
71CDK70.49980371
72CDK10.47560444
73DMPK0.47434910
74PRKDC0.46079891
75OBSCN0.45443359
76PDK20.45302833
77GRK50.45073514
78CDK20.42133796
79PNCK0.41832731
80PRKCI0.40374406
81RPS6KB20.39757251
82PIM10.39696375
83TLK10.39514489
84IRAK10.39040872
85STK240.37260484
86BCR0.37104151
87CSNK1E0.34732930
88ADRBK20.33724570
89CSNK1A1L0.33288802
90RPS6KA50.31375019
91CLK10.31250718
92MARK30.31122647
93MAPK130.30744847
94PAK30.30437512
95CSNK2A20.29071637
96TXK0.28663414
97CDK60.28143972
98CSNK2A10.27427187
99MAPKAPK50.25693564
100NEK60.25647505

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.51644721
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84506686
3Mismatch repair_Homo sapiens_hsa034303.37598531
4DNA replication_Homo sapiens_hsa030303.31173410
5Homologous recombination_Homo sapiens_hsa034403.21411495
6Proteasome_Homo sapiens_hsa030502.96259931
7Basal transcription factors_Homo sapiens_hsa030222.78816385
8Fanconi anemia pathway_Homo sapiens_hsa034602.76355115
9One carbon pool by folate_Homo sapiens_hsa006702.74021485
10RNA polymerase_Homo sapiens_hsa030202.65265390
11RNA transport_Homo sapiens_hsa030132.53188542
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38667507
13RNA degradation_Homo sapiens_hsa030182.30130518
14Cell cycle_Homo sapiens_hsa041102.21359555
15Selenocompound metabolism_Homo sapiens_hsa004502.11249347
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10242170
17Propanoate metabolism_Homo sapiens_hsa006402.03649558
18Base excision repair_Homo sapiens_hsa034101.99336164
19Spliceosome_Homo sapiens_hsa030401.98693407
20Nucleotide excision repair_Homo sapiens_hsa034201.92551184
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.87528333
22Vitamin B6 metabolism_Homo sapiens_hsa007501.62099357
23Protein export_Homo sapiens_hsa030601.60704638
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53983149
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45524863
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42774801
27mRNA surveillance pathway_Homo sapiens_hsa030151.39715474
28p53 signaling pathway_Homo sapiens_hsa041151.35968925
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24672274
30Pyrimidine metabolism_Homo sapiens_hsa002401.23981323
31Steroid biosynthesis_Homo sapiens_hsa001001.18164666
32Purine metabolism_Homo sapiens_hsa002301.18142144
33Pyruvate metabolism_Homo sapiens_hsa006201.12019447
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06722734
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02916763
36Lysine degradation_Homo sapiens_hsa003101.02575136
37Butanoate metabolism_Homo sapiens_hsa006501.02186533
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97018442
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93550768
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90344687
41Vitamin digestion and absorption_Homo sapiens_hsa049770.90200041
42Oocyte meiosis_Homo sapiens_hsa041140.87302637
43Caffeine metabolism_Homo sapiens_hsa002320.81584893
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81571778
45Primary immunodeficiency_Homo sapiens_hsa053400.79267261
46Nitrogen metabolism_Homo sapiens_hsa009100.76232409
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68316155
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67017647
49ABC transporters_Homo sapiens_hsa020100.64765931
50Ether lipid metabolism_Homo sapiens_hsa005650.62258960
51Phototransduction_Homo sapiens_hsa047440.60805094
52Systemic lupus erythematosus_Homo sapiens_hsa053220.60134303
53Tryptophan metabolism_Homo sapiens_hsa003800.58165563
54Peroxisome_Homo sapiens_hsa041460.56474017
55Fatty acid metabolism_Homo sapiens_hsa012120.55803472
56TGF-beta signaling pathway_Homo sapiens_hsa043500.55480816
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54164605
58Fatty acid biosynthesis_Homo sapiens_hsa000610.52719636
59beta-Alanine metabolism_Homo sapiens_hsa004100.51678360
60Linoleic acid metabolism_Homo sapiens_hsa005910.51444863
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49584837
62Fatty acid degradation_Homo sapiens_hsa000710.48247369
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47684990
64Metabolic pathways_Homo sapiens_hsa011000.47516291
65Retinol metabolism_Homo sapiens_hsa008300.46945502
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46445471
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45785434
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44997382
69Epstein-Barr virus infection_Homo sapiens_hsa051690.42919017
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.42742027
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42029225
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41982878
73Herpes simplex infection_Homo sapiens_hsa051680.39687496
74Taste transduction_Homo sapiens_hsa047420.36855102
75Fatty acid elongation_Homo sapiens_hsa000620.36166731
76Biosynthesis of amino acids_Homo sapiens_hsa012300.34732950
77N-Glycan biosynthesis_Homo sapiens_hsa005100.34351480
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34181590
79Viral carcinogenesis_Homo sapiens_hsa052030.34174948
80Adherens junction_Homo sapiens_hsa045200.33557785
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33201589
82MicroRNAs in cancer_Homo sapiens_hsa052060.31415380
83Huntingtons disease_Homo sapiens_hsa050160.29655358
84Tight junction_Homo sapiens_hsa045300.29526106
85Glutathione metabolism_Homo sapiens_hsa004800.28357279
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28109130
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27329356
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26605536
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.26543904
90Glycerolipid metabolism_Homo sapiens_hsa005610.26428761
91Prostate cancer_Homo sapiens_hsa052150.26420542
92Inositol phosphate metabolism_Homo sapiens_hsa005620.24752740
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.23775993
94Wnt signaling pathway_Homo sapiens_hsa043100.23134623
95Colorectal cancer_Homo sapiens_hsa052100.22489319
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20095172
97Carbon metabolism_Homo sapiens_hsa012000.18600157
98Legionellosis_Homo sapiens_hsa051340.15388685
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.15268857
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13593279

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