ZNF585B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translation, ncRNA-mediated (GO:0045974)5.55289988
2negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.55289988
3negative regulation of translation, ncRNA-mediated (GO:0040033)5.55289988
4regulation of female gonad development (GO:2000194)4.97156362
5regulation of sarcomere organization (GO:0060297)4.84830081
6sperm motility (GO:0030317)4.70898748
7behavioral response to nicotine (GO:0035095)4.53162595
8protein polyglutamylation (GO:0018095)4.35073074
9acrosome reaction (GO:0007340)4.18764791
10cilium or flagellum-dependent cell motility (GO:0001539)3.95814784
11response to misfolded protein (GO:0051788)3.88264472
12membrane depolarization during action potential (GO:0086010)3.85937984
13regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.81350583
14positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.81350583
15G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.73103665
16cellular ketone body metabolic process (GO:0046950)3.69082669
17reflex (GO:0060004)3.64474057
18monoubiquitinated protein deubiquitination (GO:0035520)3.62705866
19calcium ion-dependent exocytosis (GO:0017156)3.56326572
20multicellular organismal movement (GO:0050879)3.56011564
21musculoskeletal movement (GO:0050881)3.56011564
22fusion of sperm to egg plasma membrane (GO:0007342)3.54440601
23gamma-aminobutyric acid transport (GO:0015812)3.49335826
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46724297
25response to pheromone (GO:0019236)3.44286149
26primary amino compound metabolic process (GO:1901160)3.40524286
27regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.38390715
28positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.38390715
29multicellular organism reproduction (GO:0032504)3.38125053
30protein K48-linked deubiquitination (GO:0071108)3.36066380
31indole-containing compound catabolic process (GO:0042436)3.30235014
32indolalkylamine catabolic process (GO:0046218)3.30235014
33tryptophan catabolic process (GO:0006569)3.30235014
34NAD biosynthetic process (GO:0009435)3.26134790
35kynurenine metabolic process (GO:0070189)3.22159315
36serotonin metabolic process (GO:0042428)3.21812809
37ketone body metabolic process (GO:1902224)3.21139473
38spinal cord motor neuron differentiation (GO:0021522)3.19242840
39establishment of protein localization to Golgi (GO:0072600)3.16817785
40indolalkylamine metabolic process (GO:0006586)3.16376234
41detection of light stimulus involved in visual perception (GO:0050908)3.15278779
42detection of light stimulus involved in sensory perception (GO:0050962)3.15278779
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04362907
44microtubule depolymerization (GO:0007019)3.01274250
45pre-miRNA processing (GO:0031054)2.99856193
46neuronal action potential (GO:0019228)2.99314218
47postsynaptic membrane organization (GO:0001941)2.97358727
48peptidyl-threonine dephosphorylation (GO:0035970)2.97165997
49nonmotile primary cilium assembly (GO:0035058)2.95670895
50positive regulation of CREB transcription factor activity (GO:0032793)2.93621324
51spermatid development (GO:0007286)2.92989678
52regulation of cilium movement (GO:0003352)2.92321367
53positive regulation of mRNA catabolic process (GO:0061014)2.89577879
54appendage development (GO:0048736)2.89183056
55limb development (GO:0060173)2.89183056
56protein K63-linked deubiquitination (GO:0070536)2.88272625
57vocalization behavior (GO:0071625)2.87933135
58positive regulation of action potential (GO:0045760)2.87690309
59interkinetic nuclear migration (GO:0022027)2.87415337
60cilium movement (GO:0003341)2.83185552
61glutamate receptor signaling pathway (GO:0007215)2.81565461
62dendritic spine morphogenesis (GO:0060997)2.80818993
63epithelial cilium movement (GO:0003351)2.80268811
64transmission of nerve impulse (GO:0019226)2.79894884
65regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79705511
66indole-containing compound metabolic process (GO:0042430)2.79652479
67axoneme assembly (GO:0035082)2.77554492
68microtubule polymerization or depolymerization (GO:0031109)2.76929967
69synaptic transmission, glutamatergic (GO:0035249)2.75256718
70calcium ion import (GO:0070509)2.73213771
71cAMP catabolic process (GO:0006198)2.72116128
72neuromuscular synaptic transmission (GO:0007274)2.71067133
73tryptophan metabolic process (GO:0006568)2.70414704
74positive regulation of synapse maturation (GO:0090129)2.69695331
75axonemal dynein complex assembly (GO:0070286)2.69480439
76positive regulation of organelle assembly (GO:1902117)2.69419692
77locomotory exploration behavior (GO:0035641)2.68393941
78plasma membrane fusion (GO:0045026)2.67272767
79negative regulation of systemic arterial blood pressure (GO:0003085)2.66383153
80chemosensory behavior (GO:0007635)2.64240394
81negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64073730
82regulation of gene silencing by miRNA (GO:0060964)2.63109752
83regulation of gene silencing by RNA (GO:0060966)2.63109752
84regulation of posttranscriptional gene silencing (GO:0060147)2.63109752
85ionotropic glutamate receptor signaling pathway (GO:0035235)2.62398877
86protein localization to cilium (GO:0061512)2.61044522
87peristalsis (GO:0030432)2.60325837
88protein localization to synapse (GO:0035418)2.60188750
89potassium ion transmembrane transport (GO:0071805)2.60169149
90cellular potassium ion transport (GO:0071804)2.60169149
91cilium organization (GO:0044782)2.58676428
92regulation of synapse maturation (GO:0090128)2.56025676
93signal peptide processing (GO:0006465)2.55674087
94cilium assembly (GO:0042384)2.55170870
95regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55111913
96positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54243225
97positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.53968888
98alanine transport (GO:0032328)2.53216743
99regulation of action potential (GO:0098900)2.52610286
100regulation of Rab GTPase activity (GO:0032313)2.51753165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.09855304
2DROSHA_22980978_ChIP-Seq_HELA_Human2.72617833
3GBX2_23144817_ChIP-Seq_PC3_Human2.67093732
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.56164419
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44510256
6ZNF274_21170338_ChIP-Seq_K562_Hela2.41001129
7VDR_22108803_ChIP-Seq_LS180_Human2.33533256
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24624610
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10848805
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04353200
11CBX2_27304074_Chip-Seq_ESCs_Mouse1.97321605
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94410721
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.92084702
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92084702
15REST_21632747_ChIP-Seq_MESCs_Mouse1.85176976
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.84915798
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83992225
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.80213405
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80190143
20AR_21572438_ChIP-Seq_LNCaP_Human1.79281731
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72213812
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68845307
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68139809
24STAT3_23295773_ChIP-Seq_U87_Human1.65259718
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59464726
26SMAD4_21799915_ChIP-Seq_A2780_Human1.58556139
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54838411
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.54643849
29P300_19829295_ChIP-Seq_ESCs_Human1.53982215
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53263829
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.53056292
32TCF4_23295773_ChIP-Seq_U87_Human1.50332621
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47686383
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46927823
35ER_23166858_ChIP-Seq_MCF-7_Human1.46193666
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46158153
37BCAT_22108803_ChIP-Seq_LS180_Human1.43357009
38TAF15_26573619_Chip-Seq_HEK293_Human1.42339983
39AR_25329375_ChIP-Seq_VCAP_Human1.40774328
40CBP_20019798_ChIP-Seq_JUKART_Human1.40507182
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40507182
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.39471637
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.38441996
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.36944420
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36445396
46FUS_26573619_Chip-Seq_HEK293_Human1.35421562
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34014067
48RNF2_27304074_Chip-Seq_NSC_Mouse1.33227279
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32291363
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32291363
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31760280
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30856294
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29924021
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29733315
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26937922
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26895648
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26220692
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23070239
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.21102981
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20654541
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.20423190
62RUNX2_22187159_ChIP-Seq_PCA_Human1.18631809
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17163181
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16110070
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14431790
66SMAD3_21741376_ChIP-Seq_ESCs_Human1.13524560
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.12931746
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.12429542
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11342680
70KDM2B_26808549_Chip-Seq_REH_Human1.11075727
71SMAD4_21741376_ChIP-Seq_HESCs_Human1.10399004
72AHR_22903824_ChIP-Seq_MCF-7_Human1.09717768
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09198153
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07656371
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07300385
76AR_19668381_ChIP-Seq_PC3_Human1.06770341
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06365098
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04407766
79TCF4_22108803_ChIP-Seq_LS180_Human1.03574451
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03422583
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03407594
82RXR_22108803_ChIP-Seq_LS180_Human1.01128088
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99603447
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99141964
85WDR5_24793694_ChIP-Seq_LNCAP_Human0.98150688
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97064459
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95815026
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95661559
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95489410
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95341530
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.94952000
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.93496555
93P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93274010
94OCT1_27270436_Chip-Seq_PROSTATE_Human0.92932792
95NANOG_19829295_ChIP-Seq_ESCs_Human0.92879438
96SOX2_19829295_ChIP-Seq_ESCs_Human0.92879438
97EWS_26573619_Chip-Seq_HEK293_Human0.92876649
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91933617
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91737913
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.91703425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization2.98027440
2MP0002822_catalepsy2.96748642
3MP0003878_abnormal_ear_physiology2.90445559
4MP0005377_hearing/vestibular/ear_phenot2.90445559
5MP0001501_abnormal_sleep_pattern2.84916912
6MP0002735_abnormal_chemical_nociception2.66007392
7MP0009745_abnormal_behavioral_response2.58278087
8MP0009046_muscle_twitch2.39528152
9MP0006276_abnormal_autonomic_nervous2.27689112
10MP0001968_abnormal_touch/_nociception2.25157479
11MP0005670_abnormal_white_adipose2.20682080
12MP0000569_abnormal_digit_pigmentation2.18891658
13MP0005645_abnormal_hypothalamus_physiol2.18492537
14MP0001486_abnormal_startle_reflex2.13271227
15MP0002733_abnormal_thermal_nociception2.09966056
16MP0004142_abnormal_muscle_tone2.08651365
17MP0003195_calcinosis2.05393251
18MP0001440_abnormal_grooming_behavior2.05242103
19MP0003646_muscle_fatigue2.03612151
20MP0001485_abnormal_pinna_reflex2.03469809
21MP0002734_abnormal_mechanical_nocicepti1.99875629
22MP0002572_abnormal_emotion/affect_behav1.97657605
23MP0005551_abnormal_eye_electrophysiolog1.90940901
24MP0002653_abnormal_ependyma_morphology1.87738964
25MP0002272_abnormal_nervous_system1.87406370
26MP0001970_abnormal_pain_threshold1.84610274
27MP0003635_abnormal_synaptic_transmissio1.83090125
28MP0002557_abnormal_social/conspecific_i1.81833155
29MP0005423_abnormal_somatic_nervous1.80894158
30MP0002064_seizures1.76839836
31MP0002638_abnormal_pupillary_reflex1.76151508
32MP0001905_abnormal_dopamine_level1.74329510
33MP0002067_abnormal_sensory_capabilities1.71683611
34MP0003698_abnormal_male_reproductive1.65703720
35MP0003787_abnormal_imprinting1.65369149
36MP0001348_abnormal_lacrimal_gland1.63460406
37MP0003283_abnormal_digestive_organ1.63098894
38MP0004145_abnormal_muscle_electrophysio1.58746534
39MP0003879_abnormal_hair_cell1.53046235
40MP0004043_abnormal_pH_regulation1.52682476
41MP0004885_abnormal_endolymph1.48895222
42MP0002063_abnormal_learning/memory/cond1.48623951
43MP0003045_fibrosis1.46884785
44MP0010386_abnormal_urinary_bladder1.39784851
45MP0008877_abnormal_DNA_methylation1.39577668
46MP0002928_abnormal_bile_duct1.38782910
47MP0002736_abnormal_nociception_after1.37229536
48MP0005646_abnormal_pituitary_gland1.35417634
49MP0001929_abnormal_gametogenesis1.33123279
50MP0008872_abnormal_physiological_respon1.31978813
51MP0000026_abnormal_inner_ear1.24675858
52MP0000631_abnormal_neuroendocrine_gland1.24605363
53MP0002234_abnormal_pharynx_morphology1.21954236
54MP0004742_abnormal_vestibular_system1.21720884
55MP0001963_abnormal_hearing_physiology1.21211730
56MP0006292_abnormal_olfactory_placode1.18758767
57MP0008961_abnormal_basal_metabolism1.18539789
58MP0004859_abnormal_synaptic_plasticity1.18011919
59MP0000955_abnormal_spinal_cord1.17150660
60MP0002249_abnormal_larynx_morphology1.15097451
61MP0001984_abnormal_olfaction1.13002818
62MP0005253_abnormal_eye_physiology1.11852777
63MP0003119_abnormal_digestive_system1.09572615
64MP0004133_heterotaxia1.08992456
65MP0008569_lethality_at_weaning1.08184186
66MP0003880_abnormal_central_pattern1.07955412
67MP0005386_behavior/neurological_phenoty1.07795408
68MP0004924_abnormal_behavior1.07795408
69MP0000778_abnormal_nervous_system1.06520545
70MP0002184_abnormal_innervation1.06263382
71MP0001765_abnormal_ion_homeostasis1.03866800
72MP0004085_abnormal_heartbeat1.01005273
73MP0004130_abnormal_muscle_cell0.97608483
74MP0002909_abnormal_adrenal_gland0.97460965
75MP0002882_abnormal_neuron_morphology0.95640425
76MP0000470_abnormal_stomach_morphology0.95539181
77MP0003136_yellow_coat_color0.95211718
78MP0002752_abnormal_somatic_nervous0.95096798
79MP0000230_abnormal_systemic_arterial0.93497437
80MP0002229_neurodegeneration0.91468140
81MP0005167_abnormal_blood-brain_barrier0.88282067
82MP0004270_analgesia0.87059356
83MP0002168_other_aberrant_phenotype0.86535456
84MP0005448_abnormal_energy_balance0.85420196
85MP0003137_abnormal_impulse_conducting0.85355479
86MP0002210_abnormal_sex_determination0.84336496
87MP0003632_abnormal_nervous_system0.79300503
88MP0000538_abnormal_urinary_bladder0.78759547
89MP0006072_abnormal_retinal_apoptosis0.77336384
90MP0008995_early_reproductive_senescence0.77047040
91MP0002876_abnormal_thyroid_physiology0.76375531
92MP0003718_maternal_effect0.76325636
93MP0002066_abnormal_motor_capabilities/c0.76305203
94MP0005195_abnormal_posterior_eye0.75615214
95MP0002161_abnormal_fertility/fecundity0.75415229
96MP0003633_abnormal_nervous_system0.74654560
97MP0000653_abnormal_sex_gland0.74573245
98MP0003631_nervous_system_phenotype0.72619900
99MP0001944_abnormal_pancreas_morphology0.72213077
100MP0001879_abnormal_lymphatic_vessel0.71617163

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)7.53083006
2Progressive cerebellar ataxia (HP:0002073)5.82053663
3Gaze-evoked nystagmus (HP:0000640)4.10867625
4Abnormality of binocular vision (HP:0011514)3.97643192
5Diplopia (HP:0000651)3.97643192
6Hyperventilation (HP:0002883)3.88810046
7Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.51371747
8Attenuation of retinal blood vessels (HP:0007843)3.49942981
9Nephronophthisis (HP:0000090)3.43842965
10Decreased circulating renin level (HP:0003351)3.36543108
11Retinal dysplasia (HP:0007973)3.35478310
12Congenital stationary night blindness (HP:0007642)3.34310981
13Hypoplastic ischia (HP:0003175)3.33535072
14Chronic hepatic failure (HP:0100626)3.21256406
15Pancreatic cysts (HP:0001737)3.17330064
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.16443554
17Absent/shortened dynein arms (HP:0200106)3.16443554
18Protruding tongue (HP:0010808)3.04568803
19Abnormality of the renal medulla (HP:0100957)3.02000289
20Abnormality of the ischium (HP:0003174)3.00027597
21Impaired smooth pursuit (HP:0007772)2.97707237
22Severe visual impairment (HP:0001141)2.96604730
23Bony spicule pigmentary retinopathy (HP:0007737)2.94513589
24Polydipsia (HP:0001959)2.91140051
25Abnormal drinking behavior (HP:0030082)2.91140051
26Dysmetric saccades (HP:0000641)2.87801407
27Sclerocornea (HP:0000647)2.80645467
28Pancreatic fibrosis (HP:0100732)2.77080535
29Abnormality of midbrain morphology (HP:0002418)2.75401119
30Molar tooth sign on MRI (HP:0002419)2.75401119
31True hermaphroditism (HP:0010459)2.69711480
32Hyperkalemia (HP:0002153)2.66897925
33Clumsiness (HP:0002312)2.66864783
34Abnormality of the pubic bones (HP:0003172)2.65721091
35Decreased central vision (HP:0007663)2.60609091
36Abnormal ciliary motility (HP:0012262)2.53383959
37Postural instability (HP:0002172)2.51935011
38Febrile seizures (HP:0002373)2.51117323
39Abolished electroretinogram (ERG) (HP:0000550)2.49386413
40Cystic liver disease (HP:0006706)2.49041613
41Focal seizures (HP:0007359)2.44724900
42Broad-based gait (HP:0002136)2.44042896
43Abnormal respiratory motile cilium morphology (HP:0005938)2.41352763
44Abnormal respiratory epithelium morphology (HP:0012253)2.41352763
45Hemiparesis (HP:0001269)2.39432690
46Visual hallucinations (HP:0002367)2.36993899
47Dialeptic seizures (HP:0011146)2.34223303
48Abnormality of renin-angiotensin system (HP:0000847)2.29435088
49Abnormality of the renal cortex (HP:0011035)2.29362925
50Abnormality of the diencephalon (HP:0010662)2.25908034
51Large for gestational age (HP:0001520)2.25845565
52Urinary bladder sphincter dysfunction (HP:0002839)2.21463302
53Abnormality of macular pigmentation (HP:0008002)2.20205467
54Polyuria (HP:0000103)2.19364877
55Congenital sensorineural hearing impairment (HP:0008527)2.19069245
56Inability to walk (HP:0002540)2.18662752
57Epileptic encephalopathy (HP:0200134)2.15022964
58Abnormal respiratory motile cilium physiology (HP:0012261)2.11748701
59Abnormality of ocular smooth pursuit (HP:0000617)2.11561991
60Tubular atrophy (HP:0000092)2.08685017
61Focal motor seizures (HP:0011153)2.07080704
62Medial flaring of the eyebrow (HP:0010747)2.06985406
63Truncal obesity (HP:0001956)2.06913391
64Absence seizures (HP:0002121)2.02104720
65Narrow nasal bridge (HP:0000446)2.01600581
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99639331
67Ectopic kidney (HP:0000086)1.99624792
68Abnormality of the renal collecting system (HP:0004742)1.95536085
69Congenital hepatic fibrosis (HP:0002612)1.94240845
70Increased corneal curvature (HP:0100692)1.93949298
71Keratoconus (HP:0000563)1.93949298
72Abnormal urine output (HP:0012590)1.93881332
73Abnormality of potassium homeostasis (HP:0011042)1.93037939
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.90537816
75Tubulointerstitial nephritis (HP:0001970)1.90180107
76Anencephaly (HP:0002323)1.89720762
77Bell-shaped thorax (HP:0001591)1.88409944
78Abnormal rod and cone electroretinograms (HP:0008323)1.88254033
79Type II lissencephaly (HP:0007260)1.86822174
80Absent speech (HP:0001344)1.86592784
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83967667
82Duplicated collecting system (HP:0000081)1.81623633
83Autoimmune thrombocytopenia (HP:0001973)1.80381208
84Genital tract atresia (HP:0001827)1.79616793
85Potter facies (HP:0002009)1.79199575
86Facial shape deformation (HP:0011334)1.79199575
87Oligodontia (HP:0000677)1.79149836
88Hypoplasia of the iris (HP:0007676)1.78365080
89Gait imbalance (HP:0002141)1.75030986
90Vaginal atresia (HP:0000148)1.73834735
91Bulbous nose (HP:0000414)1.72510631
92Dysautonomia (HP:0002459)1.72180982
93Depressed nasal tip (HP:0000437)1.71804765
94Aplasia/Hypoplasia of the lens (HP:0008063)1.71585602
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.69929358
96Lip pit (HP:0100267)1.69772011
97Patellar aplasia (HP:0006443)1.68986313
98Cerebellar dysplasia (HP:0007033)1.66728391
99Abnormality of renal excretion (HP:0011036)1.66404837
100Hemiplegia (HP:0002301)1.66022948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.42895352
2INSRR4.46655749
3ACVR1B3.29505677
4SIK23.03497509
5BMPR1B2.72431236
6CASK2.71451275
7PNCK2.36624558
8NTRK32.16910559
9CAMK1G2.12931690
10ADRBK22.06741383
11MAPK151.74580367
12PLK41.70508442
13CAMK1D1.68222364
14DAPK21.61633790
15WNK31.60323675
16GRK11.54995271
17DDR21.46994837
18STK381.37949097
19NUAK11.36188678
20MAP3K41.35648599
21MAPK131.28903373
22AKT31.24271151
23MAP4K21.23061056
24TLK11.21909488
25WNK41.14763637
26CDK121.11557133
27ADRBK11.10786373
28STK38L1.10747363
29PRKCE1.06219422
30PINK11.02184646
31MARK11.01756561
32NTRK21.00858394
33ZAK1.00547053
34PRKCG1.00449169
35PRKCH0.98503187
36SGK20.97329436
37TAOK30.93973039
38NEK20.93318480
39SGK4940.88844646
40SGK2230.88844646
41TGFBR10.88496404
42FGFR20.86169252
43TNIK0.85365019
44TNK20.85042304
45CAMKK10.84138016
46OXSR10.83782519
47WNK10.80743780
48STK110.79887161
49MKNK20.79590512
50CAMK10.79064565
51PTK2B0.78391617
52PKN10.77969747
53MAP2K20.75389235
54PRKAA10.73360479
55PRKAA20.71182614
56CAMK40.69242610
57PRKD30.68250530
58TYRO30.68096602
59RPS6KA60.65955059
60KIT0.64748101
61STK390.64062099
62MAP3K70.62057850
63SGK10.59885817
64MAP2K60.59867177
65ICK0.59687858
66PLK20.56888270
67NLK0.55059596
68PIK3CA0.51591508
69PRKG10.50454693
70CAMK2A0.49017851
71TXK0.48520322
72PAK30.47889292
73PASK0.47747594
74PRKCZ0.47342074
75CDK30.47013818
76PHKG20.45479066
77PHKG10.45479066
78TEC0.45222854
79CHUK0.43645609
80GSK3B0.41287371
81MARK20.41113167
82ERBB20.40903235
83MTOR0.39031126
84PRKACA0.37603413
85BRD40.37305653
86PRKCA0.37106223
87MAP2K10.36859989
88MAPK80.35686613
89OBSCN0.35152661
90RPS6KA20.34778664
91SGK30.34182211
92DYRK20.34078464
93CDK40.34017279
94PRKCB0.33979775
95TRIB30.32997590
96RPS6KA30.32593839
97CSNK1A10.32454545
98GRK70.32422317
99MAPK10.31870811
100PDK10.29198929

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.90395982
2Taste transduction_Homo sapiens_hsa047422.86793465
3Morphine addiction_Homo sapiens_hsa050322.76658341
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47260870
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.43637502
6GABAergic synapse_Homo sapiens_hsa047272.33946662
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33346519
8Circadian entrainment_Homo sapiens_hsa047132.20874562
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.18798182
10Glutamatergic synapse_Homo sapiens_hsa047242.16445176
11Butanoate metabolism_Homo sapiens_hsa006502.15670352
12Phototransduction_Homo sapiens_hsa047442.12709286
13Selenocompound metabolism_Homo sapiens_hsa004502.08537626
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05349603
15Insulin secretion_Homo sapiens_hsa049111.97704283
16Serotonergic synapse_Homo sapiens_hsa047261.86795847
17Olfactory transduction_Homo sapiens_hsa047401.84927134
18Linoleic acid metabolism_Homo sapiens_hsa005911.83401827
19Cholinergic synapse_Homo sapiens_hsa047251.70642335
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58851997
21Lysine degradation_Homo sapiens_hsa003101.58371506
22Calcium signaling pathway_Homo sapiens_hsa040201.57391842
23Type II diabetes mellitus_Homo sapiens_hsa049301.56134867
24ABC transporters_Homo sapiens_hsa020101.52773723
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46857126
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.43793234
27Dorso-ventral axis formation_Homo sapiens_hsa043201.43299749
28Cocaine addiction_Homo sapiens_hsa050301.42807882
29Nitrogen metabolism_Homo sapiens_hsa009101.39417406
30Gastric acid secretion_Homo sapiens_hsa049711.36118296
31Tryptophan metabolism_Homo sapiens_hsa003801.34055257
32Fatty acid biosynthesis_Homo sapiens_hsa000611.33520553
33Dopaminergic synapse_Homo sapiens_hsa047281.32365877
34Ether lipid metabolism_Homo sapiens_hsa005651.22858308
35Salivary secretion_Homo sapiens_hsa049701.22535682
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21943548
37Oxytocin signaling pathway_Homo sapiens_hsa049211.17404546
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11875330
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07975257
40cAMP signaling pathway_Homo sapiens_hsa040241.06692434
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.00280401
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98679063
43Ovarian steroidogenesis_Homo sapiens_hsa049130.92467839
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.92293744
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91073451
46Retinol metabolism_Homo sapiens_hsa008300.89493730
47Long-term depression_Homo sapiens_hsa047300.88019873
48Amphetamine addiction_Homo sapiens_hsa050310.86487955
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.86037551
50Renin secretion_Homo sapiens_hsa049240.85788841
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83351863
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79053144
53Glycerolipid metabolism_Homo sapiens_hsa005610.78866789
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78569283
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.75897215
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75304242
57Estrogen signaling pathway_Homo sapiens_hsa049150.68771852
58Synaptic vesicle cycle_Homo sapiens_hsa047210.67515527
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65648688
60Chemical carcinogenesis_Homo sapiens_hsa052040.65234025
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64552849
62Arachidonic acid metabolism_Homo sapiens_hsa005900.61057361
63Type I diabetes mellitus_Homo sapiens_hsa049400.57290069
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56624625
65Caffeine metabolism_Homo sapiens_hsa002320.55572724
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54862020
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54837789
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.52362072
69MAPK signaling pathway_Homo sapiens_hsa040100.52338352
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50694166
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46539069
72Bile secretion_Homo sapiens_hsa049760.46014468
73Ras signaling pathway_Homo sapiens_hsa040140.45620847
74Homologous recombination_Homo sapiens_hsa034400.45121605
75Cardiac muscle contraction_Homo sapiens_hsa042600.44232613
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42638815
77beta-Alanine metabolism_Homo sapiens_hsa004100.41781908
78Hedgehog signaling pathway_Homo sapiens_hsa043400.40857212
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40303790
80Fanconi anemia pathway_Homo sapiens_hsa034600.40129301
81Circadian rhythm_Homo sapiens_hsa047100.39618203
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38664286
83Axon guidance_Homo sapiens_hsa043600.38637660
84Pancreatic secretion_Homo sapiens_hsa049720.38423167
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36099696
86Histidine metabolism_Homo sapiens_hsa003400.34209686
87Protein digestion and absorption_Homo sapiens_hsa049740.33599079
88Platelet activation_Homo sapiens_hsa046110.33398661
89Notch signaling pathway_Homo sapiens_hsa043300.31519613
90RNA polymerase_Homo sapiens_hsa030200.30658671
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30163069
92Vitamin digestion and absorption_Homo sapiens_hsa049770.29032058
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28809372
94Choline metabolism in cancer_Homo sapiens_hsa052310.28430733
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27387977
96Graft-versus-host disease_Homo sapiens_hsa053320.26544398
97Basal cell carcinoma_Homo sapiens_hsa052170.25796036
98Purine metabolism_Homo sapiens_hsa002300.23927858
99mTOR signaling pathway_Homo sapiens_hsa041500.23562755
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22385439

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