ZNF584

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)4.60536579
2behavioral response to nicotine (GO:0035095)4.20953254
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.08110418
4protein-cofactor linkage (GO:0018065)3.82552306
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67915435
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.67915435
7NADH dehydrogenase complex assembly (GO:0010257)3.67915435
8protein complex biogenesis (GO:0070271)3.60818377
9pseudouridine synthesis (GO:0001522)3.49574358
10negative regulation of telomere maintenance (GO:0032205)3.49145250
11epithelial cilium movement (GO:0003351)3.44030234
12positive regulation of mitochondrial fission (GO:0090141)3.43385117
13mitochondrial respiratory chain complex assembly (GO:0033108)3.34613939
14ubiquinone biosynthetic process (GO:0006744)3.30978374
15ubiquinone metabolic process (GO:0006743)3.30304391
16water-soluble vitamin biosynthetic process (GO:0042364)3.30181236
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26436139
18centriole replication (GO:0007099)3.20646377
19fucose catabolic process (GO:0019317)3.18813512
20L-fucose metabolic process (GO:0042354)3.18813512
21L-fucose catabolic process (GO:0042355)3.18813512
22peptidyl-histidine modification (GO:0018202)3.17624604
23regulation of microtubule-based movement (GO:0060632)3.17201469
24nonmotile primary cilium assembly (GO:0035058)3.15674223
25cullin deneddylation (GO:0010388)3.12170772
26protein deneddylation (GO:0000338)3.09815290
27protein K6-linked ubiquitination (GO:0085020)3.02505580
28pyrimidine nucleobase catabolic process (GO:0006208)3.02320769
29chaperone-mediated protein transport (GO:0072321)3.01252449
30DNA deamination (GO:0045006)3.00897074
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00001702
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00001702
33ATP synthesis coupled proton transport (GO:0015986)2.95734123
34energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95734123
35preassembly of GPI anchor in ER membrane (GO:0016254)2.95393749
36protein polyglutamylation (GO:0018095)2.93980391
37tRNA processing (GO:0008033)2.93974303
38establishment of protein localization to mitochondrial membrane (GO:0090151)2.92508136
39cilium morphogenesis (GO:0060271)2.89551883
40respiratory chain complex IV assembly (GO:0008535)2.89426316
41resolution of meiotic recombination intermediates (GO:0000712)2.88781730
42transcription elongation from RNA polymerase III promoter (GO:0006385)2.88241652
43termination of RNA polymerase III transcription (GO:0006386)2.88241652
44cilium movement (GO:0003341)2.82887126
45mannosylation (GO:0097502)2.82844406
46piRNA metabolic process (GO:0034587)2.82738833
47replication fork processing (GO:0031297)2.75622613
48sequestering of actin monomers (GO:0042989)2.71410673
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70799462
50maturation of 5.8S rRNA (GO:0000460)2.70027885
51cilium organization (GO:0044782)2.69078334
52reciprocal meiotic recombination (GO:0007131)2.67055291
53reciprocal DNA recombination (GO:0035825)2.67055291
54tRNA modification (GO:0006400)2.66861808
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65278879
56regulation of nuclear cell cycle DNA replication (GO:0033262)2.64480072
57electron transport chain (GO:0022900)2.64280010
58recombinational repair (GO:0000725)2.63792962
59axonemal dynein complex assembly (GO:0070286)2.62644323
60axoneme assembly (GO:0035082)2.62327712
61double-strand break repair via homologous recombination (GO:0000724)2.61184685
62cilium assembly (GO:0042384)2.60992608
63base-excision repair, AP site formation (GO:0006285)2.59905526
64regulation of mitochondrial translation (GO:0070129)2.59110415
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58666809
66cilium or flagellum-dependent cell motility (GO:0001539)2.58482529
67male meiosis I (GO:0007141)2.57930803
68respiratory electron transport chain (GO:0022904)2.57908117
69cytochrome complex assembly (GO:0017004)2.57731149
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57178804
71response to pheromone (GO:0019236)2.56432033
72cellular ketone body metabolic process (GO:0046950)2.56146458
73isoprenoid biosynthetic process (GO:0008299)2.55702746
74GPI anchor metabolic process (GO:0006505)2.54700253
75postsynaptic membrane organization (GO:0001941)2.53793143
76proteasome assembly (GO:0043248)2.52610074
77regulation of mitotic spindle checkpoint (GO:1903504)2.51315073
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51315073
79meiotic chromosome segregation (GO:0045132)2.51131235
80mitochondrial RNA metabolic process (GO:0000959)2.51061365
81GTP biosynthetic process (GO:0006183)2.50231876
82L-methionine biosynthetic process (GO:0071265)2.50130907
83amino acid salvage (GO:0043102)2.50130907
84L-methionine salvage (GO:0071267)2.50130907
85tRNA metabolic process (GO:0006399)2.48108266
86intracellular protein transmembrane import (GO:0044743)2.47637118
87motile cilium assembly (GO:0044458)2.46294670
88nucleobase catabolic process (GO:0046113)2.46280041
89regulation of hexokinase activity (GO:1903299)2.45977621
90regulation of glucokinase activity (GO:0033131)2.45977621
91platelet dense granule organization (GO:0060155)2.45617873
92DNA methylation involved in gamete generation (GO:0043046)2.45311903
93chromatin remodeling at centromere (GO:0031055)2.45113324
94retinal ganglion cell axon guidance (GO:0031290)2.44373538
95C-terminal protein amino acid modification (GO:0018410)2.42862512
96DNA replication checkpoint (GO:0000076)2.41167003
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41089936
98centriole assembly (GO:0098534)2.41044035
99quinone biosynthetic process (GO:1901663)2.40763971
100mitochondrion morphogenesis (GO:0070584)2.40401427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.14061867
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45242861
3HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.30620179
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.20729056
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.83085525
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74155921
7EZH2_22144423_ChIP-Seq_EOC_Human2.73812697
8IGF1R_20145208_ChIP-Seq_DFB_Human2.68304405
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62290665
10VDR_22108803_ChIP-Seq_LS180_Human2.56787847
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.42945843
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42629916
13GBX2_23144817_ChIP-Seq_PC3_Human2.40354045
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.35411542
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30028451
16VDR_23849224_ChIP-Seq_CD4+_Human2.10276958
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06755966
18* MYC_18940864_ChIP-ChIP_HL60_Human2.06406481
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05989917
20TP53_22573176_ChIP-Seq_HFKS_Human1.97952718
21EWS_26573619_Chip-Seq_HEK293_Human1.96938920
22IRF1_19129219_ChIP-ChIP_H3396_Human1.91402883
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90712824
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90424371
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85573827
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85466138
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82721555
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80607414
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79591736
30ELK1_19687146_ChIP-ChIP_HELA_Human1.79227779
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76068038
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75167201
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.71105968
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68869637
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65812417
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62711237
37FOXP3_21729870_ChIP-Seq_TREG_Human1.59350139
38FUS_26573619_Chip-Seq_HEK293_Human1.57018885
39* GABP_19822575_ChIP-Seq_HepG2_Human1.55429782
40E2F7_22180533_ChIP-Seq_HELA_Human1.54982406
41TAF15_26573619_Chip-Seq_HEK293_Human1.48570441
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44803247
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44346094
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.40282441
45ER_23166858_ChIP-Seq_MCF-7_Human1.36587671
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.30636593
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30433360
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30150447
49DCP1A_22483619_ChIP-Seq_HELA_Human1.29626777
50P300_19829295_ChIP-Seq_ESCs_Human1.29401884
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28333090
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.26740248
53XRN2_22483619_ChIP-Seq_HELA_Human1.20377341
54TTF2_22483619_ChIP-Seq_HELA_Human1.19786649
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.16870116
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.15785099
57NCOR_22424771_ChIP-Seq_293T_Human1.15172064
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11683979
59RNF2_27304074_Chip-Seq_NSC_Mouse1.11617298
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.11553946
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11553946
62HOXB7_26014856_ChIP-Seq_BT474_Human1.10161910
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09689669
64REST_21632747_ChIP-Seq_MESCs_Mouse1.09243641
65AR_20517297_ChIP-Seq_VCAP_Human1.09137779
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08006465
67ERA_21632823_ChIP-Seq_H3396_Human1.06848535
68KDM5A_27292631_Chip-Seq_BREAST_Human1.05880485
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.04862669
70CBP_20019798_ChIP-Seq_JUKART_Human1.04535830
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04535830
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03524762
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03396286
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03095936
75AR_25329375_ChIP-Seq_VCAP_Human0.99474827
76MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97689296
77REST_18959480_ChIP-ChIP_MESCs_Mouse0.96439116
78MYC_18555785_ChIP-Seq_MESCs_Mouse0.96380850
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95974160
80PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95344201
81KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94840994
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94117815
83* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91869736
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91305659
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91023422
86MYC_19829295_ChIP-Seq_ESCs_Human0.90521141
87STAT3_23295773_ChIP-Seq_U87_Human0.90062880
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89238983
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87867866
90P53_21459846_ChIP-Seq_SAOS-2_Human0.87204700
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85818341
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85508021
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85492503
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84938488
95RUNX2_22187159_ChIP-Seq_PCA_Human0.84803745
96SMAD4_21799915_ChIP-Seq_A2780_Human0.84688257
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84522936
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.83746263
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.83539545
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83416311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.13165660
2MP0006292_abnormal_olfactory_placode2.63507633
3MP0002653_abnormal_ependyma_morphology2.46281117
4MP0003880_abnormal_central_pattern2.41534724
5MP0001529_abnormal_vocalization2.34987774
6MP0008058_abnormal_DNA_repair2.25067689
7MP0005551_abnormal_eye_electrophysiolog2.24778023
8MP0001986_abnormal_taste_sensitivity2.21261999
9MP0003136_yellow_coat_color2.21216464
10MP0008877_abnormal_DNA_methylation2.19389476
11MP0006276_abnormal_autonomic_nervous2.19189062
12MP0004147_increased_porphyrin_level2.13851065
13MP0002938_white_spotting2.09815322
14MP0002638_abnormal_pupillary_reflex2.05028429
15MP0006072_abnormal_retinal_apoptosis1.99477445
16MP0002837_dystrophic_cardiac_calcinosis1.75390299
17MP0000427_abnormal_hair_cycle1.75270952
18MP0009046_muscle_twitch1.73419144
19MP0002736_abnormal_nociception_after1.69377462
20MP0001968_abnormal_touch/_nociception1.67658154
21MP0001984_abnormal_olfaction1.65705437
22MP0008875_abnormal_xenobiotic_pharmacok1.64871176
23MP0004133_heterotaxia1.64289505
24MP0000631_abnormal_neuroendocrine_gland1.61613352
25MP0005253_abnormal_eye_physiology1.61504068
26MP0003195_calcinosis1.60444001
27MP0005646_abnormal_pituitary_gland1.59814457
28MP0005645_abnormal_hypothalamus_physiol1.59046836
29MP0003718_maternal_effect1.58974548
30MP0004142_abnormal_muscle_tone1.58905860
31MP0002234_abnormal_pharynx_morphology1.54680413
32MP0008789_abnormal_olfactory_epithelium1.50280491
33MP0009745_abnormal_behavioral_response1.49771709
34MP0002272_abnormal_nervous_system1.46810551
35MP0003787_abnormal_imprinting1.46060855
36MP0000372_irregular_coat_pigmentation1.45978369
37MP0010094_abnormal_chromosome_stability1.45886255
38MP0002160_abnormal_reproductive_system1.39917393
39MP0004043_abnormal_pH_regulation1.38872223
40MP0003786_premature_aging1.36484044
41MP0005171_absent_coat_pigmentation1.35969200
42MP0000778_abnormal_nervous_system1.35200845
43MP0010386_abnormal_urinary_bladder1.33112592
44MP0005423_abnormal_somatic_nervous1.30564049
45MP0004145_abnormal_muscle_electrophysio1.28350614
46MP0008872_abnormal_physiological_respon1.25141134
47MP0002735_abnormal_chemical_nociception1.25021120
48MP0001905_abnormal_dopamine_level1.24477613
49MP0002876_abnormal_thyroid_physiology1.23406698
50MP0004885_abnormal_endolymph1.22845154
51MP0000569_abnormal_digit_pigmentation1.21413091
52MP0000647_abnormal_sebaceous_gland1.20240062
53MP0002572_abnormal_emotion/affect_behav1.18558763
54MP0001486_abnormal_startle_reflex1.12350528
55MP0002557_abnormal_social/conspecific_i1.11699147
56MP0005499_abnormal_olfactory_system1.10383905
57MP0005394_taste/olfaction_phenotype1.10383905
58MP0005174_abnormal_tail_pigmentation1.09651135
59MP0005195_abnormal_posterior_eye1.09517957
60MP0005084_abnormal_gallbladder_morpholo1.09192463
61MP0006035_abnormal_mitochondrial_morpho1.08188102
62MP0008775_abnormal_heart_ventricle1.07952526
63MP0002210_abnormal_sex_determination1.07665355
64MP0002067_abnormal_sensory_capabilities1.07549168
65MP0002095_abnormal_skin_pigmentation1.06532045
66MP0002752_abnormal_somatic_nervous1.06508531
67MP0003646_muscle_fatigue1.05424239
68MP0006036_abnormal_mitochondrial_physio1.02939873
69MP0003121_genomic_imprinting1.02921383
70MP0001929_abnormal_gametogenesis1.02542639
71MP0003698_abnormal_male_reproductive1.02465418
72MP0003011_delayed_dark_adaptation1.01859040
73MP0005389_reproductive_system_phenotype1.01078520
74MP0001502_abnormal_circadian_rhythm1.00556486
75MP0005386_behavior/neurological_phenoty1.00348732
76MP0004924_abnormal_behavior1.00348732
77MP0000026_abnormal_inner_ear0.99806336
78MP0002063_abnormal_learning/memory/cond0.99484143
79MP0002064_seizures0.99353031
80MP0001485_abnormal_pinna_reflex0.98628695
81MP0000538_abnormal_urinary_bladder0.97968632
82MP0001970_abnormal_pain_threshold0.96747245
83MP0002184_abnormal_innervation0.96664943
84MP0002734_abnormal_mechanical_nocicepti0.95226163
85MP0003635_abnormal_synaptic_transmissio0.94476929
86MP0002751_abnormal_autonomic_nervous0.94393703
87MP0001501_abnormal_sleep_pattern0.94223482
88MP0002928_abnormal_bile_duct0.94002756
89MP0003937_abnormal_limbs/digits/tail_de0.93512425
90MP0000750_abnormal_muscle_regeneration0.90771392
91MP0004742_abnormal_vestibular_system0.90492089
92MP0000049_abnormal_middle_ear0.89325082
93MP0003693_abnormal_embryo_hatching0.88324501
94MP0005410_abnormal_fertilization0.88101859
95MP0000383_abnormal_hair_follicle0.87796221
96MP0008995_early_reproductive_senescence0.87550482
97MP0000955_abnormal_spinal_cord0.87133310
98MP0002733_abnormal_thermal_nociception0.86539184
99MP0009697_abnormal_copulation0.85012606
100MP0003122_maternal_imprinting0.83808385

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.69837396
2Pancreatic cysts (HP:0001737)4.33229110
3Molar tooth sign on MRI (HP:0002419)4.28080918
4Abnormality of midbrain morphology (HP:0002418)4.28080918
5Retinal dysplasia (HP:0007973)3.97406447
6Pancreatic fibrosis (HP:0100732)3.97033917
7True hermaphroditism (HP:0010459)3.92243357
8Cerebellar dysplasia (HP:0007033)3.59581417
9Nephronophthisis (HP:0000090)3.53924208
10Medial flaring of the eyebrow (HP:0010747)3.50223043
11Hypoplasia of the pons (HP:0012110)3.42914664
12Abnormality of the pons (HP:0007361)3.25012590
13Acute necrotizing encephalopathy (HP:0006965)3.04928953
14Gait imbalance (HP:0002141)2.93610043
15Abnormality of the renal medulla (HP:0100957)2.90676810
16Congenital primary aphakia (HP:0007707)2.84020003
17Lissencephaly (HP:0001339)2.83706194
18Abnormality of the renal cortex (HP:0011035)2.81596470
19Abnormal mitochondria in muscle tissue (HP:0008316)2.77101167
20Congenital stationary night blindness (HP:0007642)2.75409144
21Sclerocornea (HP:0000647)2.72725172
22Severe muscular hypotonia (HP:0006829)2.70098015
23Acute encephalopathy (HP:0006846)2.66142113
24Absent/shortened dynein arms (HP:0200106)2.66004568
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.66004568
26Cystic liver disease (HP:0006706)2.62198633
27Mitochondrial inheritance (HP:0001427)2.61689025
28Nephrogenic diabetes insipidus (HP:0009806)2.60036713
29Methylmalonic acidemia (HP:0002912)2.57560211
30Abnormal respiratory motile cilium morphology (HP:0005938)2.57495652
31Abnormal respiratory epithelium morphology (HP:0012253)2.57495652
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.54447982
33Increased CSF lactate (HP:0002490)2.52966205
34Renal cortical cysts (HP:0000803)2.47713705
35Progressive macrocephaly (HP:0004481)2.46355323
36Methylmalonic aciduria (HP:0012120)2.43866823
37Abnormal ciliary motility (HP:0012262)2.37844159
38Rib fusion (HP:0000902)2.37147396
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.37049172
40Abnormality of alanine metabolism (HP:0010916)2.35153175
41Hyperalaninemia (HP:0003348)2.35153175
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35153175
43Chronic hepatic failure (HP:0100626)2.34784497
44Inability to walk (HP:0002540)2.31542622
45Abnormal number of erythroid precursors (HP:0012131)2.30642823
46Postaxial foot polydactyly (HP:0001830)2.25974206
47Patellar aplasia (HP:0006443)2.25176920
48Aplasia/Hypoplasia of the patella (HP:0006498)2.23163498
49Polydipsia (HP:0001959)2.21139040
50Abnormal drinking behavior (HP:0030082)2.21139040
51Progressive inability to walk (HP:0002505)2.18826972
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15806911
53Abnormal respiratory motile cilium physiology (HP:0012261)2.15343868
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14334032
55Tubular atrophy (HP:0000092)2.13587164
56Congenital hepatic fibrosis (HP:0002612)2.13094624
57Hyperventilation (HP:0002883)2.11890117
58Pachygyria (HP:0001302)2.11575118
59Abolished electroretinogram (ERG) (HP:0000550)2.11534397
60Short tibia (HP:0005736)2.10740014
61Attenuation of retinal blood vessels (HP:0007843)2.09349678
62Increased serum lactate (HP:0002151)2.07385386
63Occipital encephalocele (HP:0002085)2.05894897
64Absent thumb (HP:0009777)2.04270431
65Genital tract atresia (HP:0001827)2.03907144
66Optic disc pallor (HP:0000543)2.02057803
67Vaginal atresia (HP:0000148)2.02021869
68Preaxial hand polydactyly (HP:0001177)2.00179510
69Poor coordination (HP:0002370)1.99075199
70Optic nerve hypoplasia (HP:0000609)1.99000145
71Lipid accumulation in hepatocytes (HP:0006561)1.98721961
72Anencephaly (HP:0002323)1.98192662
73Aplasia/hypoplasia of the uterus (HP:0008684)1.95338769
74Hepatocellular necrosis (HP:0001404)1.94480833
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94087875
76Poor head control (HP:0002421)1.93978499
77Birth length less than 3rd percentile (HP:0003561)1.93094267
78Lactic acidosis (HP:0003128)1.92633702
79Concave nail (HP:0001598)1.89435180
80Increased hepatocellular lipid droplets (HP:0006565)1.89144741
81Cerebral edema (HP:0002181)1.88819562
82Pendular nystagmus (HP:0012043)1.88549665
83Abnormality of DNA repair (HP:0003254)1.87658285
84Rhinitis (HP:0012384)1.87084619
85Male pseudohermaphroditism (HP:0000037)1.86362583
86Abnormality of cells of the erythroid lineage (HP:0012130)1.86054357
87Postaxial hand polydactyly (HP:0001162)1.86009854
883-Methylglutaconic aciduria (HP:0003535)1.85204451
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.83346244
90Hepatic necrosis (HP:0002605)1.82609812
91Aganglionic megacolon (HP:0002251)1.82481758
92Hypoplasia of the brainstem (HP:0002365)1.80149503
93Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80149503
94Bony spicule pigmentary retinopathy (HP:0007737)1.78400407
95Colon cancer (HP:0003003)1.76503969
96Furrowed tongue (HP:0000221)1.75191675
97Polyuria (HP:0000103)1.75139186
98Progressive microcephaly (HP:0000253)1.75123531
99Oculomotor apraxia (HP:0000657)1.74907776
100Abnormal rod and cone electroretinograms (HP:0008323)1.74172282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.01550902
2MAP4K24.29087473
3ZAK2.94702841
4FRK2.81335168
5ADRBK22.34765712
6TLK12.31434887
7WNK32.27661460
8BMPR1B2.24188237
9BCKDK2.14222478
10MAPK132.12815986
11NEK22.06106807
12WNK42.03522614
13CASK1.83514245
14TAOK31.80166067
15PLK41.71056469
16MAPK151.65547128
17GRK11.63678179
18MAP3K41.62351847
19MARK11.61527576
20PINK11.59481759
21PNCK1.58966334
22MAP2K71.47555953
23VRK11.47303346
24DYRK21.45166228
25VRK21.42925538
26NUAK11.39458975
27INSRR1.34979118
28SRPK11.29946766
29TRIM281.23878907
30CSNK1G31.21399014
31BUB11.18512120
32CSNK1G21.14612567
33WEE11.11457523
34PLK21.03921303
35CSNK1A1L1.02454503
36PHKG21.00140860
37PHKG11.00140860
38CDC70.97520294
39STK160.97349726
40TSSK60.94523822
41RPS6KA50.91861635
42ERBB30.89821542
43BCR0.88502444
44CSNK1G10.87626386
45LIMK10.84747720
46MARK30.84289640
47ADRBK10.83687337
48EPHA40.82845196
49CCNB10.82265222
50DAPK20.81391870
51PAK30.80350276
52NTRK20.80306153
53PLK10.79479903
54DYRK30.79435801
55PLK30.79335779
56CDK80.78551302
57TXK0.78333436
58RPS6KA40.76851535
59STK100.76416260
60MAPKAPK50.76385216
61NME10.76087178
62CHEK20.75547657
63MAPKAPK30.74613377
64PTK2B0.73650148
65PRKCG0.72633652
66BRSK20.71937026
67PIM20.71414658
68STK390.70720099
69AURKA0.69059425
70TNIK0.65450690
71EIF2AK10.64884556
72PRKCE0.64411001
73ATR0.62468114
74PKN10.61097571
75PDK20.60215425
76PRKCI0.58939025
77CAMKK20.58593557
78NTRK30.54269442
79CSNK1A10.53299801
80EPHA30.52770612
81GRK70.49630901
82MAP2K20.48702991
83TGFBR10.48611763
84PAK60.46354407
85AURKB0.45990118
86ATM0.45638425
87IKBKB0.44805462
88OXSR10.43977164
89CAMK2A0.43143132
90LMTK20.42668193
91MAP2K60.39285036
92PRKACB0.39215422
93PRKACA0.38759225
94CSNK1D0.37409430
95EPHB20.36596593
96ABL20.33519735
97TESK20.33371752
98CSNK2A10.33357550
99MKNK20.30639831
100OBSCN0.30120522

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.00252333
2RNA polymerase_Homo sapiens_hsa030202.66049785
3Fanconi anemia pathway_Homo sapiens_hsa034602.54850233
4Parkinsons disease_Homo sapiens_hsa050122.53892364
5Homologous recombination_Homo sapiens_hsa034402.47686258
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45109412
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41000103
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39107825
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15469533
10Huntingtons disease_Homo sapiens_hsa050162.02142583
11Basal transcription factors_Homo sapiens_hsa030221.98030943
12Butanoate metabolism_Homo sapiens_hsa006501.96370337
13Sulfur relay system_Homo sapiens_hsa041221.95373170
14Phototransduction_Homo sapiens_hsa047441.94813436
15Steroid biosynthesis_Homo sapiens_hsa001001.94710179
16Protein export_Homo sapiens_hsa030601.85098138
17Selenocompound metabolism_Homo sapiens_hsa004501.76412721
18Mismatch repair_Homo sapiens_hsa034301.75966733
19Ribosome_Homo sapiens_hsa030101.74147347
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73454523
21Nitrogen metabolism_Homo sapiens_hsa009101.71058966
22Propanoate metabolism_Homo sapiens_hsa006401.67209416
23Linoleic acid metabolism_Homo sapiens_hsa005911.64781222
24RNA degradation_Homo sapiens_hsa030181.63801277
25Nucleotide excision repair_Homo sapiens_hsa034201.63141081
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63054379
27Proteasome_Homo sapiens_hsa030501.62640534
28DNA replication_Homo sapiens_hsa030301.59105420
29Alzheimers disease_Homo sapiens_hsa050101.56810282
30Pyrimidine metabolism_Homo sapiens_hsa002401.50369173
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48802587
32Nicotine addiction_Homo sapiens_hsa050331.46814239
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45219955
34Cardiac muscle contraction_Homo sapiens_hsa042601.43329395
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40904682
36One carbon pool by folate_Homo sapiens_hsa006701.38725821
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34396713
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30472224
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28150063
40Base excision repair_Homo sapiens_hsa034101.26879671
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22992817
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.22796213
43Purine metabolism_Homo sapiens_hsa002301.21524538
44RNA transport_Homo sapiens_hsa030131.21010378
45Regulation of autophagy_Homo sapiens_hsa041401.16599227
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14492982
47Ether lipid metabolism_Homo sapiens_hsa005651.08395253
48Tryptophan metabolism_Homo sapiens_hsa003801.06564436
49Non-homologous end-joining_Homo sapiens_hsa034501.02573012
50Fatty acid elongation_Homo sapiens_hsa000620.96869223
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94484267
52Olfactory transduction_Homo sapiens_hsa047400.93937106
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.92383274
54Peroxisome_Homo sapiens_hsa041460.91757820
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90812786
56Taste transduction_Homo sapiens_hsa047420.88902949
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85027161
58Spliceosome_Homo sapiens_hsa030400.83617905
59Metabolic pathways_Homo sapiens_hsa011000.83130690
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79184996
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.74008128
62Morphine addiction_Homo sapiens_hsa050320.73218479
63Folate biosynthesis_Homo sapiens_hsa007900.71106116
64Sulfur metabolism_Homo sapiens_hsa009200.70708222
65Fatty acid metabolism_Homo sapiens_hsa012120.68297795
66Insulin secretion_Homo sapiens_hsa049110.63592605
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62635544
68Chemical carcinogenesis_Homo sapiens_hsa052040.61101089
69GABAergic synapse_Homo sapiens_hsa047270.61014509
70Caffeine metabolism_Homo sapiens_hsa002320.56939436
71Pyruvate metabolism_Homo sapiens_hsa006200.56757229
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55448848
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.53534844
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51634471
75ABC transporters_Homo sapiens_hsa020100.49439397
76Hedgehog signaling pathway_Homo sapiens_hsa043400.49384731
77Collecting duct acid secretion_Homo sapiens_hsa049660.48954481
78Cocaine addiction_Homo sapiens_hsa050300.48937417
79Circadian rhythm_Homo sapiens_hsa047100.48719013
80p53 signaling pathway_Homo sapiens_hsa041150.48636281
81Arachidonic acid metabolism_Homo sapiens_hsa005900.47913137
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45730050
83Vitamin B6 metabolism_Homo sapiens_hsa007500.44843934
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44735852
85Ovarian steroidogenesis_Homo sapiens_hsa049130.44594174
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44041351
87Glutathione metabolism_Homo sapiens_hsa004800.43479218
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43434677
89mRNA surveillance pathway_Homo sapiens_hsa030150.42976096
90Cell cycle_Homo sapiens_hsa041100.42185665
91Basal cell carcinoma_Homo sapiens_hsa052170.41375909
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40296548
93Circadian entrainment_Homo sapiens_hsa047130.37322715
94beta-Alanine metabolism_Homo sapiens_hsa004100.36760153
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36163295
96Salivary secretion_Homo sapiens_hsa049700.33669872
97Alcoholism_Homo sapiens_hsa050340.32887342
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31603901
99Serotonergic synapse_Homo sapiens_hsa047260.30791651
100Dopaminergic synapse_Homo sapiens_hsa047280.30277795

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