ZNF583

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.28675899
2kidney morphogenesis (GO:0060993)4.27679357
3DNA deamination (GO:0045006)4.18720759
4pyrimidine nucleobase catabolic process (GO:0006208)4.06765056
5negative regulation of telomere maintenance (GO:0032205)3.94849532
6urinary tract smooth muscle contraction (GO:0014848)3.93336755
7atrial cardiac muscle cell action potential (GO:0086014)3.84697948
8postsynaptic membrane organization (GO:0001941)3.83709427
9L-fucose catabolic process (GO:0042355)3.77814266
10fucose catabolic process (GO:0019317)3.77814266
11L-fucose metabolic process (GO:0042354)3.77814266
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75921086
13presynaptic membrane assembly (GO:0097105)3.70292501
14pseudouridine synthesis (GO:0001522)3.42589718
15protein-cofactor linkage (GO:0018065)3.41396447
16nucleobase catabolic process (GO:0046113)3.40122175
17detection of light stimulus involved in visual perception (GO:0050908)3.37973203
18detection of light stimulus involved in sensory perception (GO:0050962)3.37973203
19piRNA metabolic process (GO:0034587)3.28166317
20nonmotile primary cilium assembly (GO:0035058)3.25978471
21neuron cell-cell adhesion (GO:0007158)3.24895476
22regulation of microtubule-based movement (GO:0060632)3.22447566
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17470767
24presynaptic membrane organization (GO:0097090)3.15957941
25neural tube formation (GO:0001841)3.12822169
26peristalsis (GO:0030432)3.12600720
27protein polyglutamylation (GO:0018095)3.12561308
28water-soluble vitamin biosynthetic process (GO:0042364)3.09948650
29protein localization to cilium (GO:0061512)3.09376300
30cornea development in camera-type eye (GO:0061303)3.08094780
31gamma-aminobutyric acid transport (GO:0015812)3.04360955
32response to pheromone (GO:0019236)3.03515708
33preassembly of GPI anchor in ER membrane (GO:0016254)2.99570389
34regulation of telomere maintenance (GO:0032204)2.98918807
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96130084
36mitochondrial respiratory chain complex I assembly (GO:0032981)2.96130084
37NADH dehydrogenase complex assembly (GO:0010257)2.96130084
38regulation of respiratory system process (GO:0044065)2.94033704
39epithelial cilium movement (GO:0003351)2.89303692
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87932498
41adult feeding behavior (GO:0008343)2.85991345
42regulation of action potential (GO:0098900)2.85846721
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84937860
44regulation of cilium movement (GO:0003352)2.82924887
45cellular ketone body metabolic process (GO:0046950)2.82336961
46head development (GO:0060322)2.81062731
47negative regulation of systemic arterial blood pressure (GO:0003085)2.81049931
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.78832021
49positive regulation of action potential (GO:0045760)2.76789620
50protein complex biogenesis (GO:0070271)2.76402390
51negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75728595
52positive regulation of mitochondrial fission (GO:0090141)2.75215733
53vocalization behavior (GO:0071625)2.73848964
54platelet dense granule organization (GO:0060155)2.72388399
55cilium morphogenesis (GO:0060271)2.70135981
56regulation of glucokinase activity (GO:0033131)2.69281435
57regulation of hexokinase activity (GO:1903299)2.69281435
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68721370
59indole-containing compound catabolic process (GO:0042436)2.62543966
60indolalkylamine catabolic process (GO:0046218)2.62543966
61tryptophan catabolic process (GO:0006569)2.62543966
62glycosphingolipid biosynthetic process (GO:0006688)2.62471203
63neuronal action potential (GO:0019228)2.62108109
64axoneme assembly (GO:0035082)2.61068579
65indolalkylamine metabolic process (GO:0006586)2.59699594
66synapse assembly (GO:0007416)2.58485669
67DNA demethylation (GO:0080111)2.58405700
68positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57659001
69mitochondrial respiratory chain complex assembly (GO:0033108)2.57440529
70auditory behavior (GO:0031223)2.57297263
71kynurenine metabolic process (GO:0070189)2.56879199
72phasic smooth muscle contraction (GO:0014821)2.56832101
73ubiquinone biosynthetic process (GO:0006744)2.56819236
74protein localization to synapse (GO:0035418)2.55751508
75somite development (GO:0061053)2.55747794
76behavioral response to ethanol (GO:0048149)2.55258284
77negative regulation of organelle assembly (GO:1902116)2.55138781
78regulation of mesoderm development (GO:2000380)2.54685437
79arginine catabolic process (GO:0006527)2.54260061
80C4-dicarboxylate transport (GO:0015740)2.53958782
81positive regulation of sodium ion transmembrane transport (GO:1902307)2.53754380
82ubiquinone metabolic process (GO:0006743)2.52874857
83synaptic transmission, cholinergic (GO:0007271)2.51289028
84ketone body metabolic process (GO:1902224)2.50974334
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50901158
86cilium organization (GO:0044782)2.50890263
87negative regulation of mast cell activation (GO:0033004)2.50613525
88limb bud formation (GO:0060174)2.50220232
89positive regulation of guanylate cyclase activity (GO:0031284)2.49284657
90GPI anchor metabolic process (GO:0006505)2.47946341
91L-methionine salvage (GO:0071267)2.47825923
92L-methionine biosynthetic process (GO:0071265)2.47825923
93amino acid salvage (GO:0043102)2.47825923
94positive regulation of oligodendrocyte differentiation (GO:0048714)2.47583177
95glycerophospholipid catabolic process (GO:0046475)2.47434897
96primary amino compound metabolic process (GO:1901160)2.46453281
97cilium assembly (GO:0042384)2.45825983
98neurotransmitter-gated ion channel clustering (GO:0072578)2.45560833
99sulfation (GO:0051923)2.45403142
100anterograde axon cargo transport (GO:0008089)2.43864498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.28838066
2EZH2_22144423_ChIP-Seq_EOC_Human3.38445758
3GBX2_23144817_ChIP-Seq_PC3_Human3.29879471
4VDR_22108803_ChIP-Seq_LS180_Human2.93647565
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78867449
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72965995
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55939063
8IGF1R_20145208_ChIP-Seq_DFB_Human2.45403003
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39508063
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27568625
11FUS_26573619_Chip-Seq_HEK293_Human2.26363053
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26178210
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07628808
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04127816
15P300_19829295_ChIP-Seq_ESCs_Human2.03035969
16EWS_26573619_Chip-Seq_HEK293_Human2.00397676
17TAF15_26573619_Chip-Seq_HEK293_Human1.98193341
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84312366
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.83804518
20ER_23166858_ChIP-Seq_MCF-7_Human1.81288098
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.79500517
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73125679
23REST_21632747_ChIP-Seq_MESCs_Mouse1.72129731
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.71079545
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65578282
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63873028
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60722617
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60500363
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.58724192
30TP53_22573176_ChIP-Seq_HFKS_Human1.58358072
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57781407
32RNF2_27304074_Chip-Seq_NSC_Mouse1.57411173
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56573412
34SMAD4_21799915_ChIP-Seq_A2780_Human1.55001368
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54142844
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52610562
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51933775
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50168466
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50168466
40AR_25329375_ChIP-Seq_VCAP_Human1.50020584
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48497338
42STAT3_23295773_ChIP-Seq_U87_Human1.48164784
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47480261
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.45946010
45BCAT_22108803_ChIP-Seq_LS180_Human1.43976517
46TCF4_23295773_ChIP-Seq_U87_Human1.43331101
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43273358
48CBP_20019798_ChIP-Seq_JUKART_Human1.43273358
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42544111
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.42500833
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40941048
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40458457
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39088536
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.36538749
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.29133546
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.28995691
57TCF4_22108803_ChIP-Seq_LS180_Human1.26915011
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25556679
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25492887
60* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25237317
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24544263
62AR_21572438_ChIP-Seq_LNCaP_Human1.24307513
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24158437
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24083981
65NANOG_19829295_ChIP-Seq_ESCs_Human1.23658744
66SOX2_19829295_ChIP-Seq_ESCs_Human1.23658744
67MYC_18940864_ChIP-ChIP_HL60_Human1.22907742
68RUNX2_22187159_ChIP-Seq_PCA_Human1.21497606
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21482125
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19253558
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.18493867
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18099976
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.16901731
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16901731
75IRF1_19129219_ChIP-ChIP_H3396_Human1.16046111
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.15430381
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.12236611
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.11759257
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10723199
80NCOR_22424771_ChIP-Seq_293T_Human1.10722313
81* EST1_17652178_ChIP-ChIP_JURKAT_Human1.08982667
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08892992
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08246071
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.07378752
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06904610
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06154530
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05180308
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.05106480
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04596474
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.03494309
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02402500
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01820902
93HOXB7_26014856_ChIP-Seq_BT474_Human1.01502502
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99698485
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99480339
96AR_20517297_ChIP-Seq_VCAP_Human0.99471384
97MYC_19829295_ChIP-Seq_ESCs_Human0.98707435
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.98702969
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.97955684
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97642141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.76509887
2MP0002102_abnormal_ear_morphology3.69552133
3MP0008877_abnormal_DNA_methylation2.84971725
4MP0002735_abnormal_chemical_nociception2.71539129
5MP0003787_abnormal_imprinting2.41899294
6MP0001968_abnormal_touch/_nociception2.40643977
7MP0001529_abnormal_vocalization2.34542086
8MP0003880_abnormal_central_pattern2.27296775
9MP0005167_abnormal_blood-brain_barrier2.23104685
10MP0005551_abnormal_eye_electrophysiolog2.21175800
11MP0003646_muscle_fatigue2.13574439
12MP0009046_muscle_twitch2.12263143
13MP0009745_abnormal_behavioral_response2.09396045
14MP0002736_abnormal_nociception_after2.08516212
15MP0002837_dystrophic_cardiac_calcinosis2.02406316
16MP0003195_calcinosis2.01705277
17MP0008872_abnormal_physiological_respon1.98421496
18MP0000569_abnormal_digit_pigmentation1.93064528
19MP0005645_abnormal_hypothalamus_physiol1.89214633
20MP0001984_abnormal_olfaction1.85098949
21MP0002822_catalepsy1.80132991
22MP0002272_abnormal_nervous_system1.78799183
23MP0002638_abnormal_pupillary_reflex1.77725555
24MP0004043_abnormal_pH_regulation1.75230952
25MP0006292_abnormal_olfactory_placode1.73813550
26MP0006276_abnormal_autonomic_nervous1.71789623
27MP0005253_abnormal_eye_physiology1.71132027
28MP0005386_behavior/neurological_phenoty1.68943563
29MP0004924_abnormal_behavior1.68943563
30MP0006072_abnormal_retinal_apoptosis1.68861096
31MP0001486_abnormal_startle_reflex1.67473682
32MP0004133_heterotaxia1.65323021
33MP0001970_abnormal_pain_threshold1.62285204
34MP0002572_abnormal_emotion/affect_behav1.61301803
35MP0002734_abnormal_mechanical_nocicepti1.59840169
36MP0004142_abnormal_muscle_tone1.57272719
37MP0004885_abnormal_endolymph1.57088484
38MP0003635_abnormal_synaptic_transmissio1.55352618
39MP0002733_abnormal_thermal_nociception1.53392256
40MP0002064_seizures1.53074715
41MP0003122_maternal_imprinting1.50412977
42MP0003011_delayed_dark_adaptation1.49913157
43MP0002063_abnormal_learning/memory/cond1.48954390
44MP0002557_abnormal_social/conspecific_i1.42189754
45MP0001501_abnormal_sleep_pattern1.41552500
46MP0002653_abnormal_ependyma_morphology1.41282678
47MP0001986_abnormal_taste_sensitivity1.40919004
48MP0000778_abnormal_nervous_system1.37093615
49MP0005646_abnormal_pituitary_gland1.36029655
50MP0002067_abnormal_sensory_capabilities1.34980666
51MP0004742_abnormal_vestibular_system1.32938715
52MP0003137_abnormal_impulse_conducting1.29386950
53MP0000427_abnormal_hair_cycle1.27095400
54MP0008875_abnormal_xenobiotic_pharmacok1.26861193
55MP0003121_genomic_imprinting1.25546617
56MP0001905_abnormal_dopamine_level1.21758017
57MP0005084_abnormal_gallbladder_morpholo1.19529143
58MP0001485_abnormal_pinna_reflex1.18236262
59MP0003718_maternal_effect1.17895432
60MP0002234_abnormal_pharynx_morphology1.16766763
61MP0002938_white_spotting1.16337043
62MP0002876_abnormal_thyroid_physiology1.15321918
63MP0003890_abnormal_embryonic-extraembry1.13975336
64MP0004215_abnormal_myocardial_fiber1.10542505
65MP0004859_abnormal_synaptic_plasticity1.10327978
66MP0000383_abnormal_hair_follicle1.02309554
67MP0002751_abnormal_autonomic_nervous1.02279880
68MP0008775_abnormal_heart_ventricle1.00423273
69MP0000631_abnormal_neuroendocrine_gland0.98851138
70MP0002184_abnormal_innervation0.96315736
71MP0002277_abnormal_respiratory_mucosa0.95893697
72MP0005195_abnormal_posterior_eye0.95026845
73MP0003136_yellow_coat_color0.94293485
74MP0008058_abnormal_DNA_repair0.94090557
75MP0000230_abnormal_systemic_arterial0.93253031
76MP0004145_abnormal_muscle_electrophysio0.92696394
77MP0002752_abnormal_somatic_nervous0.90816034
78MP0004085_abnormal_heartbeat0.88126162
79MP0003119_abnormal_digestive_system0.85969116
80MP0000372_irregular_coat_pigmentation0.84630079
81MP0000026_abnormal_inner_ear0.84461952
82MP0010386_abnormal_urinary_bladder0.82971273
83MP0005389_reproductive_system_phenotype0.82140829
84MP0001440_abnormal_grooming_behavior0.79830877
85MP0004270_analgesia0.79142845
86MP0002160_abnormal_reproductive_system0.79060740
87MP0002882_abnormal_neuron_morphology0.78404531
88MP0005423_abnormal_somatic_nervous0.78010289
89MP0002909_abnormal_adrenal_gland0.76859794
90MP0002229_neurodegeneration0.75892398
91MP0001348_abnormal_lacrimal_gland0.75537909
92MP0003633_abnormal_nervous_system0.74625612
93MP0001963_abnormal_hearing_physiology0.73742267
94MP0001919_abnormal_reproductive_system0.73395624
95MP0005391_vision/eye_phenotype0.72692018
96MP0005448_abnormal_energy_balance0.72404616
97MP0008789_abnormal_olfactory_epithelium0.72159222
98MP0000955_abnormal_spinal_cord0.71907742
99MP0003698_abnormal_male_reproductive0.70567514
100MP0000049_abnormal_middle_ear0.70471000

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.00479642
2Pancreatic cysts (HP:0001737)4.29540386
3Hyperventilation (HP:0002883)4.02612327
4Abnormality of midbrain morphology (HP:0002418)3.95631769
5Molar tooth sign on MRI (HP:0002419)3.95631769
6Congenital stationary night blindness (HP:0007642)3.93407266
7Pancreatic fibrosis (HP:0100732)3.93096662
8True hermaphroditism (HP:0010459)3.91992226
9Type II lissencephaly (HP:0007260)3.66555397
10Nephronophthisis (HP:0000090)3.53468671
11Medial flaring of the eyebrow (HP:0010747)3.19281081
12Lissencephaly (HP:0001339)3.15516056
13Abnormality of the renal cortex (HP:0011035)3.13693555
14Inability to walk (HP:0002540)3.12950057
15Gait imbalance (HP:0002141)3.08897747
16Abnormality of the renal medulla (HP:0100957)3.08608705
17Breast hypoplasia (HP:0003187)2.85611962
18Congenital primary aphakia (HP:0007707)2.80976668
19Abolished electroretinogram (ERG) (HP:0000550)2.75138541
20Broad-based gait (HP:0002136)2.70785268
21Progressive inability to walk (HP:0002505)2.70668257
22Patellar aplasia (HP:0006443)2.70519456
23Aplasia/Hypoplasia of the patella (HP:0006498)2.56977003
24Aplasia/Hypoplasia of the sternum (HP:0006714)2.56905881
25Nephrogenic diabetes insipidus (HP:0009806)2.54155275
26Protruding tongue (HP:0010808)2.52847011
27Pendular nystagmus (HP:0012043)2.52670551
28Cystic liver disease (HP:0006706)2.48718679
29Pachygyria (HP:0001302)2.48316715
30Attenuation of retinal blood vessels (HP:0007843)2.48032173
31Microretrognathia (HP:0000308)2.45263494
32Abnormal rod and cone electroretinograms (HP:0008323)2.45141543
33Retinal dysplasia (HP:0007973)2.43126896
34Chronic hepatic failure (HP:0100626)2.41084581
35Abnormality of the labia minora (HP:0012880)2.40560588
36Polyphagia (HP:0002591)2.38749713
37Renal cortical cysts (HP:0000803)2.35688061
38Progressive cerebellar ataxia (HP:0002073)2.32583246
39Genital tract atresia (HP:0001827)2.25562631
40Abnormality of alanine metabolism (HP:0010916)2.23865965
41Hyperalaninemia (HP:0003348)2.23865965
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23865965
43Cerebellar dysplasia (HP:0007033)2.23523536
44Tubular atrophy (HP:0000092)2.23438552
45Myokymia (HP:0002411)2.23288506
46Limb dystonia (HP:0002451)2.17635646
47Scrotal hypoplasia (HP:0000046)2.17357101
48Vaginal atresia (HP:0000148)2.16180324
49Chorioretinal atrophy (HP:0000533)2.14745072
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.13778840
51Abnormal drinking behavior (HP:0030082)2.13585564
52Polydipsia (HP:0001959)2.13585564
53Genetic anticipation (HP:0003743)2.13036153
54Hemiparesis (HP:0001269)2.12369935
55Drooling (HP:0002307)2.08169497
56Bile duct proliferation (HP:0001408)2.07800896
57Abnormal biliary tract physiology (HP:0012439)2.07800896
58Mitochondrial inheritance (HP:0001427)2.07358807
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04352721
60Abnormal respiratory motile cilium morphology (HP:0005938)2.04287078
61Abnormal respiratory epithelium morphology (HP:0012253)2.04287078
62Keratoconus (HP:0000563)2.03945742
63Increased corneal curvature (HP:0100692)2.03945742
64Large for gestational age (HP:0001520)2.03718171
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.03130704
66Acute necrotizing encephalopathy (HP:0006965)2.01175663
67Sclerocornea (HP:0000647)2.00912414
68Absent speech (HP:0001344)1.97965841
69Widely spaced teeth (HP:0000687)1.97016282
70Optic nerve hypoplasia (HP:0000609)1.96965159
71Methylmalonic acidemia (HP:0002912)1.96495065
72Increased CSF lactate (HP:0002490)1.95860883
73Methylmalonic aciduria (HP:0012120)1.94341465
74Gaze-evoked nystagmus (HP:0000640)1.93298055
75Anencephaly (HP:0002323)1.91883883
76Congenital hepatic fibrosis (HP:0002612)1.90176096
77Poor speech (HP:0002465)1.89962481
78Abnormality of the pons (HP:0007361)1.89904963
79Poor coordination (HP:0002370)1.89223943
80Male pseudohermaphroditism (HP:0000037)1.89005828
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88143838
82Focal motor seizures (HP:0011153)1.87732412
83Optic disc pallor (HP:0000543)1.86914711
84Polyuria (HP:0000103)1.86627356
85Excessive salivation (HP:0003781)1.85697235
86Long foot (HP:0001833)1.85549332
87Stomach cancer (HP:0012126)1.84480342
88Lipid accumulation in hepatocytes (HP:0006561)1.82727850
89Postaxial foot polydactyly (HP:0001830)1.79380591
903-Methylglutaconic aciduria (HP:0003535)1.78385629
91Increased hepatocellular lipid droplets (HP:0006565)1.78070437
92Colon cancer (HP:0003003)1.77588271
93Hypothermia (HP:0002045)1.77164117
94Congenital, generalized hypertrichosis (HP:0004540)1.77161569
95Severe muscular hypotonia (HP:0006829)1.76857664
96Furrowed tongue (HP:0000221)1.76676485
97Febrile seizures (HP:0002373)1.76609887
98Progressive macrocephaly (HP:0004481)1.76476432
99Epileptic encephalopathy (HP:0200134)1.76420318
100Narrow forehead (HP:0000341)1.76006801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.89772910
2BMPR1B3.88289075
3FRK3.74232806
4CASK3.63726594
5DAPK23.00154936
6ZAK2.80781062
7ADRBK22.78458283
8WNK32.66201374
9MAP4K22.56509139
10MARK12.46789970
11MAPK132.30945857
12MAP3K42.19835467
13PINK12.10338490
14WNK41.96592687
15GRK11.71644756
16TGFBR11.69678896
17MAP2K71.68221044
18TLK11.63868906
19TAOK31.63375858
20INSRR1.62235299
21CAMKK21.58822047
22TNIK1.51477153
23MKNK21.38395547
24NUAK11.32472736
25BCR1.32066130
26CAMKK11.29911575
27NTRK21.29173784
28NTRK31.28595664
29BCKDK1.26113869
30SIK21.18718172
31ADRBK11.16980508
32DYRK21.16458139
33TRIM281.12596342
34TXK1.11544963
35STK38L1.11256857
36TIE11.07105017
37CSNK1G21.04641081
38PAK31.02313446
39PRKCG0.98781271
40OXSR10.94477289
41EPHA40.93723943
42CSNK1G30.91240048
43PHKG10.90287426
44PHKG20.90287426
45PNCK0.89339315
46NME10.87950599
47PRKCE0.87721138
48CSNK1G10.85553186
49STK390.84102145
50CAMK2A0.82422774
51CSNK1A1L0.76175052
52ERBB30.74916313
53DYRK30.72816600
54PTK2B0.68683573
55MKNK10.68260675
56RPS6KA50.62170575
57MAP2K60.62149760
58PLK20.61868281
59CAMK40.59462974
60VRK10.59321124
61CAMK10.51362842
62CSNK1A10.50615726
63EPHB20.49888814
64NEK20.49563339
65PKN10.49312405
66MAP2K40.49306519
67MINK10.47957289
68PRKACA0.46156343
69RPS6KA40.42440655
70PRKCZ0.40855764
71GRK70.40844901
72OBSCN0.38304819
73CDK30.36184171
74PLK40.35329798
75PRKCQ0.34770515
76PAK60.33724042
77EPHA30.33723903
78CAMK1D0.33321329
79DYRK1A0.33174450
80PLK30.32908145
81TEC0.32119232
82CCNB10.31702934
83CSNK1D0.31555674
84MAPK150.31297900
85PRKAA10.30342424
86SGK20.29090925
87MAPKAPK50.28995796
88PRKG10.28700116
89FGFR20.28346101
90PRKCA0.27636082
91PRKACB0.27040505
92SGK4940.26426997
93SGK2230.26426997
94MUSK0.25995239
95ATR0.25168219
96WEE10.24958598
97CDK50.24532940
98MAP2K10.24387521
99CHUK0.24218092
100BRSK20.24089542

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.88235684
2Nicotine addiction_Homo sapiens_hsa050332.84883147
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78410035
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50751122
5Linoleic acid metabolism_Homo sapiens_hsa005912.37803100
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37396954
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33570371
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33500881
9Butanoate metabolism_Homo sapiens_hsa006502.32676705
10Oxidative phosphorylation_Homo sapiens_hsa001902.19699726
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14121581
12Nitrogen metabolism_Homo sapiens_hsa009102.01356521
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99722839
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.97490209
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79284058
16GABAergic synapse_Homo sapiens_hsa047271.76455910
17Selenocompound metabolism_Homo sapiens_hsa004501.73243388
18Ether lipid metabolism_Homo sapiens_hsa005651.72231400
19Basal transcription factors_Homo sapiens_hsa030221.69801054
20Protein export_Homo sapiens_hsa030601.69359145
21Parkinsons disease_Homo sapiens_hsa050121.65547079
22Morphine addiction_Homo sapiens_hsa050321.62574749
23Propanoate metabolism_Homo sapiens_hsa006401.56709268
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.54635189
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47891693
26Taste transduction_Homo sapiens_hsa047421.47506450
27Circadian entrainment_Homo sapiens_hsa047131.45824284
28ABC transporters_Homo sapiens_hsa020101.35666922
29RNA polymerase_Homo sapiens_hsa030201.30555676
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29203890
31Glutamatergic synapse_Homo sapiens_hsa047241.28514151
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.27255100
33Olfactory transduction_Homo sapiens_hsa047401.25234189
34Tryptophan metabolism_Homo sapiens_hsa003801.24934353
35Serotonergic synapse_Homo sapiens_hsa047261.23878968
36Cardiac muscle contraction_Homo sapiens_hsa042601.21120377
37Fanconi anemia pathway_Homo sapiens_hsa034601.20720170
38Insulin secretion_Homo sapiens_hsa049111.20175435
39Steroid biosynthesis_Homo sapiens_hsa001001.17087145
40Peroxisome_Homo sapiens_hsa041461.16684997
41Alzheimers disease_Homo sapiens_hsa050101.16264961
42Regulation of autophagy_Homo sapiens_hsa041401.13981622
43Homologous recombination_Homo sapiens_hsa034401.13566227
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12124098
45RNA degradation_Homo sapiens_hsa030181.11018719
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10155838
47Caffeine metabolism_Homo sapiens_hsa002321.09098938
48Huntingtons disease_Homo sapiens_hsa050161.08348794
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04404911
50Collecting duct acid secretion_Homo sapiens_hsa049661.02970219
51beta-Alanine metabolism_Homo sapiens_hsa004100.96070016
52Dopaminergic synapse_Homo sapiens_hsa047280.93218814
53Chemical carcinogenesis_Homo sapiens_hsa052040.92631427
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92189949
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89774588
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.88410013
57Amphetamine addiction_Homo sapiens_hsa050310.83840183
58Salivary secretion_Homo sapiens_hsa049700.82429182
59Ovarian steroidogenesis_Homo sapiens_hsa049130.82015836
60Calcium signaling pathway_Homo sapiens_hsa040200.79179177
61Cocaine addiction_Homo sapiens_hsa050300.77671900
62Arachidonic acid metabolism_Homo sapiens_hsa005900.77524691
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71187272
64Retinol metabolism_Homo sapiens_hsa008300.68685009
65Sulfur relay system_Homo sapiens_hsa041220.68437458
66Long-term depression_Homo sapiens_hsa047300.68375715
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66869596
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65314466
69Metabolic pathways_Homo sapiens_hsa011000.62167523
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61043269
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59633502
72Fatty acid biosynthesis_Homo sapiens_hsa000610.58563342
73Glycerolipid metabolism_Homo sapiens_hsa005610.58137531
74Purine metabolism_Homo sapiens_hsa002300.56391660
75Fat digestion and absorption_Homo sapiens_hsa049750.56330066
76Circadian rhythm_Homo sapiens_hsa047100.56150456
77Oxytocin signaling pathway_Homo sapiens_hsa049210.55273379
78Axon guidance_Homo sapiens_hsa043600.53647883
79Mineral absorption_Homo sapiens_hsa049780.51072549
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51069735
81Non-homologous end-joining_Homo sapiens_hsa034500.48677869
82Cholinergic synapse_Homo sapiens_hsa047250.47826633
83Synaptic vesicle cycle_Homo sapiens_hsa047210.46294467
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45434663
85Fatty acid elongation_Homo sapiens_hsa000620.44928723
86cAMP signaling pathway_Homo sapiens_hsa040240.44134180
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.43310519
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41724444
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.39599748
90Renin secretion_Homo sapiens_hsa049240.38583455
91Pyrimidine metabolism_Homo sapiens_hsa002400.38379906
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.37206099
93One carbon pool by folate_Homo sapiens_hsa006700.36017356
94Gastric acid secretion_Homo sapiens_hsa049710.35938037
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34604663
96Dorso-ventral axis formation_Homo sapiens_hsa043200.34007418
97Vitamin digestion and absorption_Homo sapiens_hsa049770.33241729
98Arginine and proline metabolism_Homo sapiens_hsa003300.32060429
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31960490
100Hedgehog signaling pathway_Homo sapiens_hsa043400.31811337

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