ZNF579

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)7.31823524
2embryonic retina morphogenesis in camera-type eye (GO:0060059)6.93392993
3tachykinin receptor signaling pathway (GO:0007217)6.40811525
4cerebellar granule cell differentiation (GO:0021707)5.53267850
5cellular response to vitamin D (GO:0071305)5.43284383
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.25004729
7mitochondrion transport along microtubule (GO:0047497)5.25004729
8venous blood vessel morphogenesis (GO:0048845)5.16513522
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.13065275
10positive regulation of gastrulation (GO:2000543)5.08125379
11regulation of bile acid biosynthetic process (GO:0070857)4.91365610
12pattern specification involved in kidney development (GO:0061004)4.75483507
13establishment of mitochondrion localization (GO:0051654)4.73479459
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.17004036
15chemosensory behavior (GO:0007635)4.07692840
16cellular response to vitamin (GO:0071295)3.92549216
17short-term memory (GO:0007614)3.85123292
18neuronal stem cell maintenance (GO:0097150)3.84876769
19uterus development (GO:0060065)3.80917301
20regulation of sarcomere organization (GO:0060297)3.80036854
21cell migration in hindbrain (GO:0021535)3.77492784
22lymphangiogenesis (GO:0001946)3.77260012
23axon extension (GO:0048675)3.77057415
24substrate-independent telencephalic tangential migration (GO:0021826)3.74081351
25substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.74081351
26regulation of telomerase activity (GO:0051972)3.72418519
27osteoblast development (GO:0002076)3.65033755
28cell-cell junction maintenance (GO:0045217)3.58354331
29synaptic transmission, dopaminergic (GO:0001963)3.57146588
30ganglion development (GO:0061548)3.55585826
31ribosomal small subunit biogenesis (GO:0042274)3.52902260
32skeletal muscle organ development (GO:0060538)3.50859740
33neural tube development (GO:0021915)3.49066502
34urogenital system development (GO:0001655)3.48776215
35spinal cord association neuron differentiation (GO:0021527)3.48143651
36regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.46044772
37regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.46044772
38neuronal ion channel clustering (GO:0045161)3.38544952
39axon extension involved in axon guidance (GO:0048846)3.31210522
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.31210522
41response to phenylpropanoid (GO:0080184)3.28590240
42cardiac myofibril assembly (GO:0055003)3.26231250
43dentate gyrus development (GO:0021542)3.24216523
44viral transcription (GO:0019083)3.23760166
45cell differentiation in hindbrain (GO:0021533)3.23038673
46axonal fasciculation (GO:0007413)3.21863992
47ectodermal placode formation (GO:0060788)3.20017367
48dopamine receptor signaling pathway (GO:0007212)3.18161789
49neuron recognition (GO:0008038)3.15664561
50positive regulation of cell cycle checkpoint (GO:1901978)3.12440441
51establishment or maintenance of monopolar cell polarity (GO:0061339)3.08250526
52establishment of monopolar cell polarity (GO:0061162)3.08250526
53neuron projection extension (GO:1990138)3.07399980
54forebrain neuron differentiation (GO:0021879)3.04229229
55planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97787182
56cell proliferation in forebrain (GO:0021846)2.96521565
57translational termination (GO:0006415)2.95934522
58positive regulation of neurotransmitter transport (GO:0051590)2.92685238
59behavioral response to nicotine (GO:0035095)2.90431926
60negative regulation of catenin import into nucleus (GO:0035414)2.89165871
61camera-type eye morphogenesis (GO:0048593)2.89103920
62spinal cord development (GO:0021510)2.87074911
63mitochondrion localization (GO:0051646)2.85731822
64left/right pattern formation (GO:0060972)2.84734862
65locomotory exploration behavior (GO:0035641)2.84649805
66behavioral response to ethanol (GO:0048149)2.84101013
67central nervous system myelination (GO:0022010)2.83807679
68axon ensheathment in central nervous system (GO:0032291)2.83807679
69endothelial cell differentiation (GO:0045446)2.79556493
70behavioral response to cocaine (GO:0048148)2.79061683
71hepatocyte differentiation (GO:0070365)2.79010553
72regulation of transcription involved in cell fate commitment (GO:0060850)2.76238911
73positive regulation of DNA biosynthetic process (GO:2000573)2.75075640
74diaphragm development (GO:0060539)2.74574129
75ventricular septum morphogenesis (GO:0060412)2.71763893
76bone development (GO:0060348)2.69686591
77head development (GO:0060322)2.69031211
78glycerophospholipid catabolic process (GO:0046475)2.66700374
79protein insertion into membrane (GO:0051205)2.65252851
80ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.65237687
81semaphorin-plexin signaling pathway (GO:0071526)2.64577097
82base-excision repair, AP site formation (GO:0006285)2.63681977
83auditory receptor cell differentiation (GO:0042491)2.63564428
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63240282
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.59872435
86body morphogenesis (GO:0010171)2.58004652
87response to histamine (GO:0034776)2.56108342
88positive regulation of histone deacetylation (GO:0031065)2.55731235
89mating behavior (GO:0007617)2.53235651
90cochlea morphogenesis (GO:0090103)2.53079445
91regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52913416
92cell junction maintenance (GO:0034331)2.51722381
93segment specification (GO:0007379)2.50882776
94postsynaptic membrane organization (GO:0001941)2.50012406
95negative regulation of axon extension involved in axon guidance (GO:0048843)2.49685103
96cartilage condensation (GO:0001502)2.48314378
97cell aggregation (GO:0098743)2.48314378
98cellular response to nutrient (GO:0031670)2.47408544
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44563223
100synapse assembly (GO:0007416)2.44206236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.04822185
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.87181905
3EZH2_22144423_ChIP-Seq_EOC_Human3.76807888
4ERG_21242973_ChIP-ChIP_JURKAT_Human3.00895471
5LXR_22292898_ChIP-Seq_THP-1_Human2.66636719
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.53574754
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46266589
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44766718
9TP53_20018659_ChIP-ChIP_R1E_Mouse2.39537493
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37794395
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.32820142
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31719959
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.26627019
14CTCF_27219007_Chip-Seq_Bcells_Human2.24332739
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21422812
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19225488
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16851999
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.13737415
19KDM2B_26808549_Chip-Seq_K562_Human2.08617013
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04255381
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04255381
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96503300
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.95561772
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94182382
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.93441361
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92231146
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.88631725
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.87506144
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84063751
30P68_20966046_ChIP-Seq_HELA_Human1.81297750
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.78336289
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.73317868
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72772255
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71644306
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70659027
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.70252569
37VDR_21846776_ChIP-Seq_THP-1_Human1.64887714
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63908846
39OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.62185634
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.57496847
41KDM2B_26808549_Chip-Seq_DND41_Human1.56329446
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55245509
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53817181
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.52903223
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51755677
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48242349
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47566301
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.46590849
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45530026
50RACK7_27058665_Chip-Seq_MCF-7_Human1.45339545
51MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.44913491
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44634494
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41305721
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39879928
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39305859
56CREB1_26743006_Chip-Seq_LNCaP_Human1.39095634
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36204344
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.35365177
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33600529
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31939657
61STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.31474330
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30490367
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30241688
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29713128
65TP53_22127205_ChIP-Seq_IMR90_Human1.29669970
66REST_21632747_ChIP-Seq_MESCs_Mouse1.28658473
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.28594192
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25506148
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24833458
70SMC4_20622854_ChIP-Seq_HELA_Human1.22030396
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21238443
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.17639262
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17299761
74SA1_27219007_Chip-Seq_Bcells_Human1.15844101
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.14708922
76BCL6_27268052_Chip-Seq_Bcells_Human1.14691726
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.14008626
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13116078
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12844830
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12488759
81* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10528233
82SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10141536
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09937181
84E2F1_20622854_ChIP-Seq_HELA_Human1.09601703
85PHF8_20622854_ChIP-Seq_HELA_Human1.09561553
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.08699157
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06753640
88MYC_22102868_ChIP-Seq_BL_Human1.05858343
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05846779
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.04030217
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02758253
92RARA_24833708_ChIP-Seq_LIVER_Mouse1.02113809
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01306162
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01182386
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.00873044
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.98751805
97OCT4_19829295_ChIP-Seq_ESCs_Human0.97648135
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97029554
99* XRN2_22483619_ChIP-Seq_HELA_Human0.94245311
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93424121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting4.38835767
2MP0004185_abnormal_adipocyte_glucose3.88033898
3MP0003787_abnormal_imprinting3.72239435
4MP0009379_abnormal_foot_pigmentation3.26870880
5MP0001542_abnormal_bone_strength3.12100406
6MP0010368_abnormal_lymphatic_system2.74638612
7MP0005423_abnormal_somatic_nervous2.47296042
8MP0004859_abnormal_synaptic_plasticity2.39423671
9MP0000778_abnormal_nervous_system2.38037895
10MP0002163_abnormal_gland_morphology2.35581031
11MP0010030_abnormal_orbit_morphology2.20719427
12MP0003942_abnormal_urinary_system2.15775501
13MP0000566_synostosis2.12935129
14MP0003121_genomic_imprinting2.11210174
15MP0006292_abnormal_olfactory_placode2.06574310
16MP0004145_abnormal_muscle_electrophysio1.97012071
17MP0000955_abnormal_spinal_cord1.92050806
18MP0002653_abnormal_ependyma_morphology1.88297292
19MP0003646_muscle_fatigue1.78819147
20MP0002249_abnormal_larynx_morphology1.74566698
21MP0005666_abnormal_adipose_tissue1.71791791
22MP0004133_heterotaxia1.71748477
23MP0002184_abnormal_innervation1.71079911
24MP0003122_maternal_imprinting1.70980766
25MP0009053_abnormal_anal_canal1.58690968
26MP0001188_hyperpigmentation1.51202472
27MP0000049_abnormal_middle_ear1.49960656
28MP0003879_abnormal_hair_cell1.49063759
29MP0005083_abnormal_biliary_tract1.46217414
30MP0000751_myopathy1.44994915
31MP0004130_abnormal_muscle_cell1.42017691
32MP0004858_abnormal_nervous_system1.40446576
33MP0003283_abnormal_digestive_organ1.38514069
34MP0002089_abnormal_postnatal_growth/wei1.37858138
35MP0001502_abnormal_circadian_rhythm1.34647612
36MP0003890_abnormal_embryonic-extraembry1.34615142
37MP0002822_catalepsy1.32514834
38MP0001905_abnormal_dopamine_level1.31673619
39MP0006276_abnormal_autonomic_nervous1.31243433
40MP0004742_abnormal_vestibular_system1.31083454
41MP0002752_abnormal_somatic_nervous1.30817482
42MP0008789_abnormal_olfactory_epithelium1.29851936
43MP0005375_adipose_tissue_phenotype1.28455967
44MP0003861_abnormal_nervous_system1.26061839
45MP0002063_abnormal_learning/memory/cond1.25211675
46MP0000534_abnormal_ureter_morphology1.24794066
47MP0002882_abnormal_neuron_morphology1.24618849
48MP0000026_abnormal_inner_ear1.23580379
49MP0003938_abnormal_ear_development1.22850995
50MP0003635_abnormal_synaptic_transmissio1.19443380
51MP0001879_abnormal_lymphatic_vessel1.18353903
52MP0001944_abnormal_pancreas_morphology1.17889759
53MP0004885_abnormal_endolymph1.17812541
54MP0005499_abnormal_olfactory_system1.16978563
55MP0005394_taste/olfaction_phenotype1.16978563
56MP0002152_abnormal_brain_morphology1.16242883
57MP0005379_endocrine/exocrine_gland_phen1.15609463
58MP0001348_abnormal_lacrimal_gland1.15352962
59MP0000678_abnormal_parathyroid_gland1.09104315
60MP0003705_abnormal_hypodermis_morpholog1.06475150
61MP0001485_abnormal_pinna_reflex1.06020831
62MP0003755_abnormal_palate_morphology1.04944272
63MP0009250_abnormal_appendicular_skeleto1.03408959
64MP0005257_abnormal_intraocular_pressure1.03284537
65MP0003385_abnormal_body_wall1.03133224
66MP0002272_abnormal_nervous_system1.00271704
67MP0002557_abnormal_social/conspecific_i0.98849784
68MP0002572_abnormal_emotion/affect_behav0.98457988
69MP0005220_abnormal_exocrine_pancreas0.98416933
70MP0002116_abnormal_craniofacial_bone0.98304903
71MP0003119_abnormal_digestive_system0.97510622
72MP0001440_abnormal_grooming_behavior0.94043227
73MP0005451_abnormal_body_composition0.90047360
74MP0005645_abnormal_hypothalamus_physiol0.88203933
75MP0001293_anophthalmia0.87596532
76MP0003943_abnormal_hepatobiliary_system0.87336733
77MP0002932_abnormal_joint_morphology0.84979427
78MP0004811_abnormal_neuron_physiology0.84697278
79MP0009115_abnormal_fat_cell0.83926156
80MP0001286_abnormal_eye_development0.83627992
81MP0002733_abnormal_thermal_nociception0.83342915
82MP0001970_abnormal_pain_threshold0.83036074
83MP0000537_abnormal_urethra_morphology0.82535092
84MP0004134_abnormal_chest_morphology0.81756940
85MP0004510_myositis0.81590311
86MP0009745_abnormal_behavioral_response0.81224176
87MP0005195_abnormal_posterior_eye0.80280063
88MP0003329_amyloid_beta_deposits0.79470122
89MP0003948_abnormal_gas_homeostasis0.78883511
90MP0003878_abnormal_ear_physiology0.78802691
91MP0005377_hearing/vestibular/ear_phenot0.78802691
92MP0001299_abnormal_eye_distance/0.78314284
93MP0000750_abnormal_muscle_regeneration0.75416735
94MP0002066_abnormal_motor_capabilities/c0.72871010
95MP0001963_abnormal_hearing_physiology0.72583057
96MP0000759_abnormal_skeletal_muscle0.71461702
97MP0005076_abnormal_cell_differentiation0.71348721
98MP0002697_abnormal_eye_size0.71213831
99MP0005670_abnormal_white_adipose0.69511286
100MP0002064_seizures0.69463500

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.12887749
2Abnormal pancreas size (HP:0012094)4.26086008
3Partial duplication of thumb phalanx (HP:0009944)3.64523756
4Achilles tendon contracture (HP:0001771)3.54931259
5Diastasis recti (HP:0001540)3.44345639
6Partial duplication of the phalanx of hand (HP:0009999)3.37228464
7Hyperthyroidism (HP:0000836)3.35132970
8Broad distal phalanx of finger (HP:0009836)3.30716406
9Anosmia (HP:0000458)3.16956630
10Shawl scrotum (HP:0000049)3.15363136
11Limb dystonia (HP:0002451)3.14417677
12Abnormality of the Achilles tendon (HP:0005109)3.03078047
13Rib fusion (HP:0000902)2.94383751
14Neonatal hypoglycemia (HP:0001998)2.82937377
15Hypogonadotrophic hypogonadism (HP:0000044)2.78423323
16Hepatoblastoma (HP:0002884)2.77373228
17Truncus arteriosus (HP:0001660)2.54113754
18Congenital malformation of the right heart (HP:0011723)2.53611226
19Double outlet right ventricle (HP:0001719)2.53611226
20Neoplasm of the adrenal cortex (HP:0100641)2.53292320
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46065173
22Turricephaly (HP:0000262)2.44488313
23Fetal akinesia sequence (HP:0001989)2.42385413
24Abnormality of cells of the erythroid lineage (HP:0012130)2.40005196
2511 pairs of ribs (HP:0000878)2.34434339
26Abnormality of the phalanges of the hallux (HP:0010057)2.34029812
27Obstructive sleep apnea (HP:0002870)2.31661423
28Short nail (HP:0001799)2.31232036
29Adrenal hypoplasia (HP:0000835)2.30464096
30Preauricular skin tag (HP:0000384)2.28044485
31Short femoral neck (HP:0100864)2.22792860
32Abnormal number of incisors (HP:0011064)2.21362237
33Anomalous pulmonary venous return (HP:0010772)2.19404037
34Deep palmar crease (HP:0006191)2.16346302
35Abnormality of the aortic arch (HP:0012303)2.14492663
36Broad metatarsal (HP:0001783)2.14177734
37Molar tooth sign on MRI (HP:0002419)2.12839170
38Abnormality of midbrain morphology (HP:0002418)2.12839170
39Hyperacusis (HP:0010780)2.12066809
40Long palpebral fissure (HP:0000637)2.10194040
41Focal dystonia (HP:0004373)2.08437541
42Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.04755406
43Abnormality of the pulmonary veins (HP:0011718)2.04686181
44Prominent occiput (HP:0000269)2.01199359
45Type 1 muscle fiber predominance (HP:0003803)1.99270246
46Shallow orbits (HP:0000586)1.97625162
47Myopathic facies (HP:0002058)1.97156834
48Renal dysplasia (HP:0000110)1.96492086
49Hypercalcemia (HP:0003072)1.94751778
50Mitral regurgitation (HP:0001653)1.93711404
51Abnormal number of erythroid precursors (HP:0012131)1.93687075
52Progressive cerebellar ataxia (HP:0002073)1.92969894
53Squamous cell carcinoma (HP:0002860)1.91515385
54Ulnar deviation of the wrist (HP:0003049)1.91009111
55Slender long bone (HP:0003100)1.90049015
56Reticulocytopenia (HP:0001896)1.89625406
57Hyperparathyroidism (HP:0000843)1.87591916
58Nephronophthisis (HP:0000090)1.85717890
59Skin tags (HP:0010609)1.84458017
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80695993
61Microretrognathia (HP:0000308)1.80670168
62Duplication of thumb phalanx (HP:0009942)1.79856276
63Overgrowth (HP:0001548)1.79134720
64Pendular nystagmus (HP:0012043)1.77451539
65Pointed chin (HP:0000307)1.76714205
66Distal upper limb amyotrophy (HP:0007149)1.75380061
67Upper limb amyotrophy (HP:0009129)1.75380061
68Broad hallux (HP:0010055)1.74539802
69Long toe (HP:0010511)1.73948582
70Down-sloping shoulders (HP:0200021)1.72639807
71Round ear (HP:0100830)1.72029776
72Disproportionate tall stature (HP:0001519)1.71141534
73Hypoplasia of the brainstem (HP:0002365)1.70756015
74Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70756015
75Sleep apnea (HP:0010535)1.70259651
76Rectal fistula (HP:0100590)1.68528157
77Rectovaginal fistula (HP:0000143)1.68528157
78Thin bony cortex (HP:0002753)1.68440471
79Anencephaly (HP:0002323)1.68220111
80Intellectual disability, severe (HP:0010864)1.68183066
81Septo-optic dysplasia (HP:0100842)1.66783573
82Asymmetric growth (HP:0100555)1.66049585
83Difficulty climbing stairs (HP:0003551)1.64361516
84Hypercortisolism (HP:0001578)1.64352400
85Optic nerve coloboma (HP:0000588)1.63638774
86Polyphagia (HP:0002591)1.62907296
87Torticollis (HP:0000473)1.61894840
88Broad phalanges of the hand (HP:0009768)1.60803792
89Increased variability in muscle fiber diameter (HP:0003557)1.60335282
90Atelectasis (HP:0100750)1.58695958
91Severe muscular hypotonia (HP:0006829)1.58103916
92Broad finger (HP:0001500)1.57773298
93Broad toe (HP:0001837)1.57396436
94Hypokinesia (HP:0002375)1.57323124
95Abnormality of dentin (HP:0010299)1.56575534
96Sclerocornea (HP:0000647)1.55860371
97Renal Fanconi syndrome (HP:0001994)1.55789102
98Vaginal fistula (HP:0004320)1.54824766
99Spinal rigidity (HP:0003306)1.52665304
100Hypoventilation (HP:0002791)1.52585261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.16043434
2IRAK33.28005512
3TRIB33.02188284
4ICK2.73395739
5SIK22.72319096
6MARK22.57357993
7EPHB22.36624552
8MARK12.29540101
9MAP3K112.20218417
10NME21.97001647
11NTRK31.80359442
12MAP3K91.77775268
13EPHA21.77679552
14DYRK21.74196323
15LATS21.70096632
16DYRK1B1.69135243
17TAF11.68870008
18PHKG21.66032237
19PHKG11.66032237
20DYRK31.65719948
21TAOK21.65379941
22SMG11.59678257
23NTRK11.58449015
24PRPF4B1.55905722
25BRAF1.48636936
26WNK41.43969526
27RPS6KA21.39933192
28TYRO31.38990069
29CAMK1D1.38553361
30ARAF1.38504447
31LIMK11.38304841
32NTRK21.30962677
33TTN1.30459947
34PIM21.28530100
35PRKD31.16628005
36STK161.08732089
37DDR21.05671335
38PRKD21.04266864
39EEF2K1.04135214
40CAMK1G1.04012900
41DMPK1.01220999
42ABL20.99345317
43RPS6KL10.95194854
44RPS6KC10.95194854
45CAMKK10.94778878
46MINK10.91378667
47BRSK10.88533435
48DAPK30.88473658
49BCKDK0.87558557
50MAP3K100.85472574
51RIPK10.85286562
52RPS6KA60.85257961
53CDC42BPA0.79867358
54MTOR0.79399918
55MAP2K20.78639719
56PKN10.77880233
57PRKCG0.77547286
58PRKCI0.77322957
59TLK10.75572216
60VRK20.75116400
61MAP2K70.70810564
62PTK20.69918635
63AURKA0.69821155
64HIPK20.69032425
65ILK0.68336036
66STK110.68192838
67PDK20.65708039
68MUSK0.64243002
69PAK30.63330593
70STK240.62869470
71TESK10.61573187
72SIK30.59861129
73MAP2K40.59391394
74CASK0.57764090
75IRAK20.57482451
76PRKCH0.57345262
77TAOK10.56959590
78MAPKAPK50.56844381
79MAPK150.56286953
80CAMK10.54350032
81PNCK0.52682986
82CDK50.50992446
83CDK11A0.50600524
84RPS6KA10.49242035
85CAMK2B0.48765246
86PAK10.48355549
87PRKAA10.47587527
88CDK140.46687511
89GRK10.46194874
90CDK150.45580072
91PDPK10.45322755
92CHUK0.44494985
93MOS0.44024935
94CAMK2G0.41539029
95CAMK2D0.40836719
96MAPK120.40809285
97AKT10.40358077
98MAP3K60.40135054
99PTK60.38488181
100PDK10.37948148

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.32255134
2Sulfur relay system_Homo sapiens_hsa041223.27173594
3Notch signaling pathway_Homo sapiens_hsa043303.01144333
4Cardiac muscle contraction_Homo sapiens_hsa042602.38534393
5Oxidative phosphorylation_Homo sapiens_hsa001902.21311492
6Basal cell carcinoma_Homo sapiens_hsa052172.17940998
7VEGF signaling pathway_Homo sapiens_hsa043702.10850263
8Axon guidance_Homo sapiens_hsa043602.01415117
9Synaptic vesicle cycle_Homo sapiens_hsa047211.97584148
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.84910289
11Parkinsons disease_Homo sapiens_hsa050121.69386798
12Dopaminergic synapse_Homo sapiens_hsa047281.68144634
13Cocaine addiction_Homo sapiens_hsa050301.62309278
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57912010
15Bladder cancer_Homo sapiens_hsa052191.56177662
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49914401
17Dilated cardiomyopathy_Homo sapiens_hsa054141.47077781
18Melanogenesis_Homo sapiens_hsa049161.46420147
19Hippo signaling pathway_Homo sapiens_hsa043901.46289291
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46275767
21Cholinergic synapse_Homo sapiens_hsa047251.45731588
22ErbB signaling pathway_Homo sapiens_hsa040121.44268244
23Hedgehog signaling pathway_Homo sapiens_hsa043401.40825808
24Morphine addiction_Homo sapiens_hsa050321.34905754
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33392678
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32532776
27Alzheimers disease_Homo sapiens_hsa050101.30304815
28MAPK signaling pathway_Homo sapiens_hsa040101.29514525
29Glioma_Homo sapiens_hsa052141.28851749
30Collecting duct acid secretion_Homo sapiens_hsa049661.28353318
31Prion diseases_Homo sapiens_hsa050201.23828865
32Oxytocin signaling pathway_Homo sapiens_hsa049211.22396739
33Huntingtons disease_Homo sapiens_hsa050161.20452213
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.19924468
35Insulin secretion_Homo sapiens_hsa049111.15907915
36Other glycan degradation_Homo sapiens_hsa005111.15746126
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15093092
38Nicotine addiction_Homo sapiens_hsa050331.14309023
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08932057
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08283209
41Long-term depression_Homo sapiens_hsa047301.08236842
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07283902
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07055097
44Glutamatergic synapse_Homo sapiens_hsa047241.06770342
45Wnt signaling pathway_Homo sapiens_hsa043101.04104292
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03958486
47Vibrio cholerae infection_Homo sapiens_hsa051101.03726749
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03458685
49Insulin signaling pathway_Homo sapiens_hsa049100.99098248
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98349528
51Gap junction_Homo sapiens_hsa045400.97494150
52mTOR signaling pathway_Homo sapiens_hsa041500.95510006
53Circadian entrainment_Homo sapiens_hsa047130.95020651
54Phototransduction_Homo sapiens_hsa047440.94602751
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.93599769
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90177305
57Endometrial cancer_Homo sapiens_hsa052130.90034448
58RNA polymerase_Homo sapiens_hsa030200.85635013
59GnRH signaling pathway_Homo sapiens_hsa049120.85341155
60Chronic myeloid leukemia_Homo sapiens_hsa052200.84877024
61Melanoma_Homo sapiens_hsa052180.83156729
62Non-small cell lung cancer_Homo sapiens_hsa052230.81704303
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81637961
64GABAergic synapse_Homo sapiens_hsa047270.81117098
65Estrogen signaling pathway_Homo sapiens_hsa049150.79016918
66Prolactin signaling pathway_Homo sapiens_hsa049170.77193061
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77138906
68Amphetamine addiction_Homo sapiens_hsa050310.76887668
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74285365
70AMPK signaling pathway_Homo sapiens_hsa041520.72946073
71Rap1 signaling pathway_Homo sapiens_hsa040150.69830597
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66769296
73Alcoholism_Homo sapiens_hsa050340.65994374
74Gastric acid secretion_Homo sapiens_hsa049710.64861075
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.63962719
76Long-term potentiation_Homo sapiens_hsa047200.62602782
77Endocytosis_Homo sapiens_hsa041440.62410268
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60807255
79Tight junction_Homo sapiens_hsa045300.59094454
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58655664
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58560098
82Ras signaling pathway_Homo sapiens_hsa040140.58275945
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.57583614
84Choline metabolism in cancer_Homo sapiens_hsa052310.57564143
85Focal adhesion_Homo sapiens_hsa045100.53979516
86Serotonergic synapse_Homo sapiens_hsa047260.52156953
87Pathways in cancer_Homo sapiens_hsa052000.51481453
88Lysine degradation_Homo sapiens_hsa003100.48884710
89Base excision repair_Homo sapiens_hsa034100.48521920
90Proteoglycans in cancer_Homo sapiens_hsa052050.48075367
91Inositol phosphate metabolism_Homo sapiens_hsa005620.47298885
92Type II diabetes mellitus_Homo sapiens_hsa049300.46646405
93Lysosome_Homo sapiens_hsa041420.45656162
94MicroRNAs in cancer_Homo sapiens_hsa052060.45263162
95Renal cell carcinoma_Homo sapiens_hsa052110.44297146
96Calcium signaling pathway_Homo sapiens_hsa040200.44171892
97Glucagon signaling pathway_Homo sapiens_hsa049220.43823440
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43706526
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.43136579
100cAMP signaling pathway_Homo sapiens_hsa040240.42079386

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