ZNF573

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.22275260
2protein polyglutamylation (GO:0018095)4.10941013
3pyrimidine nucleobase catabolic process (GO:0006208)3.81967994
4epithelial cilium movement (GO:0003351)3.78995282
5behavioral response to nicotine (GO:0035095)3.75728959
6water-soluble vitamin biosynthetic process (GO:0042364)3.67053969
7intraciliary transport (GO:0042073)3.57099323
8protein localization to cilium (GO:0061512)3.52827305
9cellular ketone body metabolic process (GO:0046950)3.48214660
10presynaptic membrane assembly (GO:0097105)3.37079100
11nucleobase catabolic process (GO:0046113)3.29990548
12respiratory chain complex IV assembly (GO:0008535)3.22821013
13resolution of meiotic recombination intermediates (GO:0000712)3.21699643
14nonmotile primary cilium assembly (GO:0035058)3.21235000
15preassembly of GPI anchor in ER membrane (GO:0016254)3.19667354
16regulation of hexokinase activity (GO:1903299)3.17924246
17regulation of glucokinase activity (GO:0033131)3.17924246
18protein complex biogenesis (GO:0070271)3.17078428
19cilium assembly (GO:0042384)3.16794621
20cilium organization (GO:0044782)3.15640957
21cilium morphogenesis (GO:0060271)3.14750669
22positive regulation of mitochondrial fission (GO:0090141)3.13715814
23cilium movement (GO:0003341)3.13434579
24ketone body metabolic process (GO:1902224)3.12953316
25DNA double-strand break processing (GO:0000729)3.11502066
26neural tube formation (GO:0001841)3.09360561
27neuron fate determination (GO:0048664)3.08848631
28regulation of cilium movement (GO:0003352)3.07464518
29fucose catabolic process (GO:0019317)3.05382244
30L-fucose metabolic process (GO:0042354)3.05382244
31L-fucose catabolic process (GO:0042355)3.05382244
32retinal ganglion cell axon guidance (GO:0031290)3.02705371
33NADH dehydrogenase complex assembly (GO:0010257)2.99338762
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99338762
35mitochondrial respiratory chain complex I assembly (GO:0032981)2.99338762
36axoneme assembly (GO:0035082)2.98800476
37mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.98083029
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.98083029
39mitochondrial respiratory chain complex assembly (GO:0033108)2.94920885
40platelet dense granule organization (GO:0060155)2.94194909
41spinal cord motor neuron differentiation (GO:0021522)2.90819908
42detection of light stimulus involved in sensory perception (GO:0050962)2.88770451
43detection of light stimulus involved in visual perception (GO:0050908)2.88770451
44cytochrome complex assembly (GO:0017004)2.86422933
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83117355
46presynaptic membrane organization (GO:0097090)2.77671736
47GPI anchor metabolic process (GO:0006505)2.72404055
48somatic hypermutation of immunoglobulin genes (GO:0016446)2.72094281
49somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72094281
50peptidyl-histidine modification (GO:0018202)2.71667968
51negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69980037
52gamma-aminobutyric acid transport (GO:0015812)2.67958341
53synapsis (GO:0007129)2.64217017
54indolalkylamine metabolic process (GO:0006586)2.62407034
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62055618
56regulation of telomere maintenance (GO:0032204)2.58375529
57neuron cell-cell adhesion (GO:0007158)2.57598438
58regulation of action potential (GO:0098900)2.57110533
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56565752
60protein-cofactor linkage (GO:0018065)2.55749522
61cullin deneddylation (GO:0010388)2.55271962
62olfactory bulb development (GO:0021772)2.53705273
63cornea development in camera-type eye (GO:0061303)2.53425193
64photoreceptor cell maintenance (GO:0045494)2.53080115
65glycosphingolipid biosynthetic process (GO:0006688)2.52982244
66inositol phosphate catabolic process (GO:0071545)2.51359911
67behavioral response to ethanol (GO:0048149)2.50954648
68dendritic spine morphogenesis (GO:0060997)2.50897408
69somite development (GO:0061053)2.50722163
70cellular component assembly involved in morphogenesis (GO:0010927)2.48819948
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48571198
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46603097
73photoreceptor cell development (GO:0042461)2.46408226
74C-terminal protein amino acid modification (GO:0018410)2.45542777
75anterograde synaptic vesicle transport (GO:0048490)2.45407307
76S-adenosylmethionine metabolic process (GO:0046500)2.44555568
77adenosine metabolic process (GO:0046085)2.44402088
78hindbrain development (GO:0030902)2.44225666
79C-terminal protein lipidation (GO:0006501)2.43387551
80single strand break repair (GO:0000012)2.42729446
81proline transport (GO:0015824)2.42674878
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.42622957
83neuronal action potential (GO:0019228)2.41785434
84postsynaptic membrane organization (GO:0001941)2.41557801
85regulation of development, heterochronic (GO:0040034)2.41292290
86protein K11-linked deubiquitination (GO:0035871)2.40999130
87negative regulation of telomere maintenance (GO:0032205)2.40824463
88anterograde axon cargo transport (GO:0008089)2.40123590
89regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.39451789
90acrosome reaction (GO:0007340)2.38903438
91negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38462528
92transmission of nerve impulse (GO:0019226)2.36303933
93GPI anchor biosynthetic process (GO:0006506)2.35801349
94regulation of timing of cell differentiation (GO:0048505)2.35761934
95adult feeding behavior (GO:0008343)2.35678577
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.34353543
97ATP synthesis coupled proton transport (GO:0015986)2.33731230
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.33731230
99startle response (GO:0001964)2.33425857
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.32809784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.42739006
2GBX2_23144817_ChIP-Seq_PC3_Human3.07004405
3IGF1R_20145208_ChIP-Seq_DFB_Human3.05612507
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89906406
5EZH2_22144423_ChIP-Seq_EOC_Human2.79739522
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77857795
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74115348
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69788254
9VDR_22108803_ChIP-Seq_LS180_Human2.50903988
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50644585
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41845736
12FUS_26573619_Chip-Seq_HEK293_Human2.31815691
13EWS_26573619_Chip-Seq_HEK293_Human2.22895839
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20435404
15P300_19829295_ChIP-Seq_ESCs_Human2.12436878
16TAF15_26573619_Chip-Seq_HEK293_Human2.10796271
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10325437
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99357964
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.98686898
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98365232
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94078036
22* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93363321
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.85918134
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80304050
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.77876194
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72799064
27* EST1_17652178_ChIP-ChIP_JURKAT_Human1.71264606
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69868971
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68068166
30SMAD4_21799915_ChIP-Seq_A2780_Human1.63018193
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58958323
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58615734
33CBP_20019798_ChIP-Seq_JUKART_Human1.58615734
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58225896
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57274870
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56338132
37ELK1_19687146_ChIP-ChIP_HELA_Human1.54494625
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54332309
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.53253306
40ER_23166858_ChIP-Seq_MCF-7_Human1.52247586
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51448772
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49122391
43AR_25329375_ChIP-Seq_VCAP_Human1.44478878
44RNF2_27304074_Chip-Seq_NSC_Mouse1.44477012
45IRF1_19129219_ChIP-ChIP_H3396_Human1.44347159
46* STAT3_23295773_ChIP-Seq_U87_Human1.42725510
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.42473185
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40882504
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40848433
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39279097
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37550486
52BCAT_22108803_ChIP-Seq_LS180_Human1.36720853
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35408259
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35117749
55MYC_18940864_ChIP-ChIP_HL60_Human1.34579681
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31889653
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31641959
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31210618
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.29404624
60TP53_22573176_ChIP-Seq_HFKS_Human1.29266107
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26024465
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.24439939
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23568830
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23568830
65TCF4_23295773_ChIP-Seq_U87_Human1.22735330
66REST_21632747_ChIP-Seq_MESCs_Mouse1.22189769
67TCF4_22108803_ChIP-Seq_LS180_Human1.21742198
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21214623
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20915762
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20891290
71VDR_23849224_ChIP-Seq_CD4+_Human1.20169637
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.20145718
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.17100688
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17039262
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16807264
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14359599
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13753840
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13606068
79SOX2_19829295_ChIP-Seq_ESCs_Human1.09565769
80NANOG_19829295_ChIP-Seq_ESCs_Human1.09565769
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08186439
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.07750797
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06134802
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.05592836
85P53_22387025_ChIP-Seq_ESCs_Mouse1.05295844
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.04471143
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.03254091
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.03093536
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03093536
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02807244
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01425253
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01191083
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01014070
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.00047302
95NCOR_22424771_ChIP-Seq_293T_Human0.99726891
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99477336
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.98893224
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.98667407
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97406935
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96617568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.03010330
2MP0003787_abnormal_imprinting2.98143504
3MP0003122_maternal_imprinting2.58253618
4MP0002102_abnormal_ear_morphology2.53386871
5MP0000569_abnormal_digit_pigmentation2.50567056
6MP0003121_genomic_imprinting2.41317411
7MP0003880_abnormal_central_pattern2.40381493
8MP0006072_abnormal_retinal_apoptosis2.31966556
9MP0001529_abnormal_vocalization2.21742435
10MP0002837_dystrophic_cardiac_calcinosis2.17415400
11MP0006276_abnormal_autonomic_nervous2.04308644
12MP0005551_abnormal_eye_electrophysiolog2.02304085
13MP0001968_abnormal_touch/_nociception1.97008409
14MP0001984_abnormal_olfaction1.90377764
15MP0009046_muscle_twitch1.83597239
16MP0004142_abnormal_muscle_tone1.78741973
17MP0005253_abnormal_eye_physiology1.75983652
18MP0009745_abnormal_behavioral_response1.73913005
19MP0003011_delayed_dark_adaptation1.71381859
20MP0005645_abnormal_hypothalamus_physiol1.69552885
21MP0002638_abnormal_pupillary_reflex1.69552576
22MP0001486_abnormal_startle_reflex1.69007771
23MP0002938_white_spotting1.68591277
24MP0002736_abnormal_nociception_after1.67173885
25MP0006292_abnormal_olfactory_placode1.63297856
26MP0002272_abnormal_nervous_system1.62645821
27MP0004133_heterotaxia1.62561056
28MP0008058_abnormal_DNA_repair1.59404190
29MP0005646_abnormal_pituitary_gland1.58860510
30MP0002751_abnormal_autonomic_nervous1.57074192
31MP0003195_calcinosis1.53904841
32MP0008995_early_reproductive_senescence1.51524494
33MP0004147_increased_porphyrin_level1.49454400
34MP0001986_abnormal_taste_sensitivity1.48686798
35MP0008789_abnormal_olfactory_epithelium1.47272034
36MP0000631_abnormal_neuroendocrine_gland1.47255862
37MP0009780_abnormal_chondrocyte_physiolo1.46009847
38MP0004885_abnormal_endolymph1.43556323
39MP0000778_abnormal_nervous_system1.42930744
40MP0002653_abnormal_ependyma_morphology1.42097718
41MP0005084_abnormal_gallbladder_morpholo1.41266319
42MP0002064_seizures1.37189664
43MP0002735_abnormal_chemical_nociception1.34797437
44MP0005394_taste/olfaction_phenotype1.34055774
45MP0005499_abnormal_olfactory_system1.34055774
46MP0005379_endocrine/exocrine_gland_phen1.33487637
47MP0005386_behavior/neurological_phenoty1.32792017
48MP0004924_abnormal_behavior1.32792017
49MP0002163_abnormal_gland_morphology1.31735271
50MP0002557_abnormal_social/conspecific_i1.31392241
51MP0002572_abnormal_emotion/affect_behav1.29400778
52MP0003635_abnormal_synaptic_transmissio1.19912019
53MP0001501_abnormal_sleep_pattern1.18486673
54MP0002067_abnormal_sensory_capabilities1.17713923
55MP0002734_abnormal_mechanical_nocicepti1.17516053
56MP0004270_analgesia1.17361232
57MP0010386_abnormal_urinary_bladder1.13315001
58MP0005174_abnormal_tail_pigmentation1.12082256
59MP0005423_abnormal_somatic_nervous1.12043776
60MP0006054_spinal_hemorrhage1.10760650
61MP0002909_abnormal_adrenal_gland1.10069730
62MP0001485_abnormal_pinna_reflex1.09847160
63MP0005410_abnormal_fertilization1.07735814
64MP0002063_abnormal_learning/memory/cond1.06961124
65MP0001970_abnormal_pain_threshold1.05870188
66MP0002160_abnormal_reproductive_system1.05771488
67MP0004043_abnormal_pH_regulation1.04359683
68MP0003698_abnormal_male_reproductive1.02444322
69MP0000647_abnormal_sebaceous_gland1.02154976
70MP0002822_catalepsy1.01910474
71MP0002254_reproductive_system_inflammat1.00064107
72MP0005389_reproductive_system_phenotype0.99683024
73MP0003890_abnormal_embryonic-extraembry0.97206536
74MP0001764_abnormal_homeostasis0.96990514
75MP0008872_abnormal_physiological_respon0.96687089
76MP0001929_abnormal_gametogenesis0.96628874
77MP0002184_abnormal_innervation0.96494742
78MP0000372_irregular_coat_pigmentation0.95174056
79MP0005195_abnormal_posterior_eye0.94960893
80MP0000955_abnormal_spinal_cord0.94685651
81MP0002095_abnormal_skin_pigmentation0.94572931
82MP0003646_muscle_fatigue0.94262540
83MP0001293_anophthalmia0.94153232
84MP0002928_abnormal_bile_duct0.93419201
85MP0001188_hyperpigmentation0.92847515
86MP0001905_abnormal_dopamine_level0.92702644
87MP0001919_abnormal_reproductive_system0.92660545
88MP0004215_abnormal_myocardial_fiber0.91749332
89MP0002733_abnormal_thermal_nociception0.91624438
90MP0002752_abnormal_somatic_nervous0.90637604
91MP0000516_abnormal_urinary_system0.88228837
92MP0005367_renal/urinary_system_phenotyp0.88228837
93MP0003137_abnormal_impulse_conducting0.88205322
94MP0004145_abnormal_muscle_electrophysio0.87401293
95MP0003718_maternal_effect0.86440551
96MP0004742_abnormal_vestibular_system0.85182968
97MP0008875_abnormal_xenobiotic_pharmacok0.84152062
98MP0002882_abnormal_neuron_morphology0.83560731
99MP0003567_abnormal_fetal_cardiomyocyte0.82872152
100MP0002210_abnormal_sex_determination0.82355041

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.28632957
2Pancreatic cysts (HP:0001737)4.18908881
3Pancreatic fibrosis (HP:0100732)4.18267343
4Abnormality of midbrain morphology (HP:0002418)3.50564383
5Molar tooth sign on MRI (HP:0002419)3.50564383
6Nephronophthisis (HP:0000090)3.45042343
7Medial flaring of the eyebrow (HP:0010747)3.42245728
8Methylmalonic acidemia (HP:0002912)3.30683149
9Gait imbalance (HP:0002141)3.05073660
10Congenital primary aphakia (HP:0007707)2.94165135
11Type II lissencephaly (HP:0007260)2.90722681
12Chronic hepatic failure (HP:0100626)2.87377381
13Abnormality of the renal medulla (HP:0100957)2.86987731
14Nephrogenic diabetes insipidus (HP:0009806)2.85338373
15Congenital stationary night blindness (HP:0007642)2.79579124
16Methylmalonic aciduria (HP:0012120)2.69244428
17Polyphagia (HP:0002591)2.63262238
18Focal motor seizures (HP:0011153)2.60825756
19Acute necrotizing encephalopathy (HP:0006965)2.56601047
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.55660000
21Genital tract atresia (HP:0001827)2.54049672
22Abnormality of the renal cortex (HP:0011035)2.49277893
23Cystic liver disease (HP:0006706)2.48978238
24Lissencephaly (HP:0001339)2.47748146
25Cerebellar dysplasia (HP:0007033)2.43640821
26Hyperventilation (HP:0002883)2.42864687
27Postaxial foot polydactyly (HP:0001830)2.42599270
28Vaginal atresia (HP:0000148)2.41161513
29Colon cancer (HP:0003003)2.37745621
30Progressive inability to walk (HP:0002505)2.35137939
31Renal cortical cysts (HP:0000803)2.34781791
32Abnormality of vitamin B metabolism (HP:0004340)2.32950186
33Male pseudohermaphroditism (HP:0000037)2.31173096
34Progressive macrocephaly (HP:0004481)2.28949485
35Broad-based gait (HP:0002136)2.28895197
36Abolished electroretinogram (ERG) (HP:0000550)2.28604844
37Sclerocornea (HP:0000647)2.28187054
38Volvulus (HP:0002580)2.25851017
39Anencephaly (HP:0002323)2.23224999
40Acute encephalopathy (HP:0006846)2.21887576
41Hemiparesis (HP:0001269)2.19559472
42Mitochondrial inheritance (HP:0001427)2.19223189
43Occipital encephalocele (HP:0002085)2.18189644
44Hyperglycinemia (HP:0002154)2.17684357
45Abnormality of the labia minora (HP:0012880)2.16222145
46Inability to walk (HP:0002540)2.16097365
47Poor coordination (HP:0002370)2.15730060
48Drooling (HP:0002307)2.12141498
49Abnormal mitochondria in muscle tissue (HP:0008316)2.12118015
50Fair hair (HP:0002286)2.11447850
51Abnormal ciliary motility (HP:0012262)2.10938555
52Postaxial hand polydactyly (HP:0001162)2.09192190
53Abnormal respiratory epithelium morphology (HP:0012253)2.07820044
54Abnormal respiratory motile cilium morphology (HP:0005938)2.07820044
55Narrow forehead (HP:0000341)2.06272252
56Tubulointerstitial nephritis (HP:0001970)2.06112866
57Attenuation of retinal blood vessels (HP:0007843)2.03238136
58Increased CSF lactate (HP:0002490)2.02851559
59Abnormality of the vitamin B12 metabolism (HP:0004341)2.02061070
60Bile duct proliferation (HP:0001408)2.01164960
61Abnormal biliary tract physiology (HP:0012439)2.01164960
62Retinal dysplasia (HP:0007973)2.00138914
63Congenital hepatic fibrosis (HP:0002612)1.98792410
64Furrowed tongue (HP:0000221)1.97805480
65Hypothermia (HP:0002045)1.97725634
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.97438995
67Gaze-evoked nystagmus (HP:0000640)1.97028489
68Abnormal rod and cone electroretinograms (HP:0008323)1.95602913
69Bony spicule pigmentary retinopathy (HP:0007737)1.94515604
70Dynein arm defect of respiratory motile cilia (HP:0012255)1.93207289
71Absent/shortened dynein arms (HP:0200106)1.93207289
72Absent speech (HP:0001344)1.92571990
73Intestinal atresia (HP:0011100)1.92371615
74Dialeptic seizures (HP:0011146)1.89314023
75Excessive salivation (HP:0003781)1.87813103
76Febrile seizures (HP:0002373)1.86247920
77Optic disc pallor (HP:0000543)1.84327086
78Focal seizures (HP:0007359)1.84020676
79Ketoacidosis (HP:0001993)1.83496683
80Polyuria (HP:0000103)1.83176767
81Pachygyria (HP:0001302)1.82228501
82Tubular atrophy (HP:0000092)1.81503561
83Abnormal drinking behavior (HP:0030082)1.81000180
84Polydipsia (HP:0001959)1.81000180
85Optic nerve hypoplasia (HP:0000609)1.78395994
86Increased hepatocellular lipid droplets (HP:0006565)1.77264367
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.77090367
88Short tibia (HP:0005736)1.75113824
89Specific learning disability (HP:0001328)1.74323005
90Hepatic necrosis (HP:0002605)1.74236945
91Astigmatism (HP:0000483)1.72418118
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72336743
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.72336743
94Broad foot (HP:0001769)1.71939258
95Lipid accumulation in hepatocytes (HP:0006561)1.70342624
96Abnormal respiratory motile cilium physiology (HP:0012261)1.69871252
97Abnormality of macular pigmentation (HP:0008002)1.69656506
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68711570
99Ketosis (HP:0001946)1.68505485
100Aplasia/hypoplasia of the uterus (HP:0008684)1.68285761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.71008137
2MAP4K23.58982238
3WNK33.04665063
4PINK12.80511917
5MARK12.74460845
6CASK2.50881091
7MAPK132.43290753
8MAP3K42.30092935
9TRIM282.22192509
10ADRBK22.19522792
11MAP3K91.99388561
12NEK11.96713656
13BMPR1B1.94331859
14GRK11.77874284
15ZAK1.77350949
16INSRR1.76396839
17BCR1.73295712
18MAP2K71.70874057
19NUAK11.68265006
20TAOK31.62608916
21CSNK1G11.60337517
22PLK21.49722442
23CSNK1G31.46484209
24PNCK1.43026138
25CSNK1G21.40631374
26EIF2AK31.40625992
27DYRK21.40566391
28ERBB31.39540951
29CSNK1A1L1.30128173
30ACVR1B1.29558691
31TNIK1.28238503
32PAK31.28174566
33NTRK31.27894720
34SRPK11.21684259
35EPHA31.16416171
36WNK41.15712234
37BCKDK1.14716137
38OXSR11.07398500
39MKNK21.06687332
40DYRK31.04989746
41PRKCE0.98722761
42VRK10.95692515
43CAMKK20.95331238
44PRKCG0.94776162
45MKNK10.90032299
46NTRK20.82751477
47PLK30.80049213
48PLK40.79108721
49STK390.78279836
50RPS6KA40.74381673
51TXK0.70169704
52UHMK10.70022879
53TGFBR10.68757314
54MINK10.68115014
55CDK190.66993829
56CAMK2A0.65647292
57EPHA40.65101534
58MST40.64294444
59DAPK20.64001375
60TLK10.63082930
61PHKG20.61443830
62PHKG10.61443830
63OBSCN0.61010440
64NLK0.59438246
65STK38L0.59420091
66FGFR20.57367766
67TSSK60.56966765
68MAPKAPK50.52233783
69FER0.51574100
70TNK20.51511322
71WEE10.50880070
72CSNK1A10.49704813
73MAP3K20.49438623
74ADRBK10.48725082
75KSR10.47829358
76TAF10.47106797
77FLT30.47032715
78PLK10.46358184
79PRKACA0.46243234
80EPHB20.44218789
81SGK20.42992707
82NEK20.41402312
83PRKACB0.41134178
84MAP2K40.39669583
85CAMK10.39083766
86RPS6KA50.38795044
87DYRK1A0.38334694
88PKN10.38017063
89BUB10.37875440
90PRKD30.37842435
91ATM0.37748352
92CSNK1D0.37551909
93BRSK20.37228356
94CAMK40.37035114
95MAPK150.36599188
96GRK70.36274813
97PASK0.35821049
98PRKG10.35755260
99CDK50.34724976
100CCNB10.34034785

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28836847
2Protein export_Homo sapiens_hsa030603.25641872
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65958958
4Oxidative phosphorylation_Homo sapiens_hsa001902.58837543
5Butanoate metabolism_Homo sapiens_hsa006502.37375586
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.29204841
7Basal transcription factors_Homo sapiens_hsa030222.28664443
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21917199
9Nicotine addiction_Homo sapiens_hsa050332.20953793
10Fanconi anemia pathway_Homo sapiens_hsa034602.17221789
11Parkinsons disease_Homo sapiens_hsa050122.14304270
12Phototransduction_Homo sapiens_hsa047442.13675954
13Selenocompound metabolism_Homo sapiens_hsa004502.13130510
14Propanoate metabolism_Homo sapiens_hsa006402.05037058
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90102870
16Homologous recombination_Homo sapiens_hsa034401.79597118
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78214483
18Non-homologous end-joining_Homo sapiens_hsa034501.76599040
19Linoleic acid metabolism_Homo sapiens_hsa005911.57631253
20RNA degradation_Homo sapiens_hsa030181.51840812
21Steroid biosynthesis_Homo sapiens_hsa001001.49825340
22RNA polymerase_Homo sapiens_hsa030201.49001421
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47271861
24Huntingtons disease_Homo sapiens_hsa050161.45530175
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43731600
26Taste transduction_Homo sapiens_hsa047421.42649852
27Tryptophan metabolism_Homo sapiens_hsa003801.42395198
28Ether lipid metabolism_Homo sapiens_hsa005651.40769053
29GABAergic synapse_Homo sapiens_hsa047271.39251999
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37534824
31Alzheimers disease_Homo sapiens_hsa050101.37353437
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36149774
33Peroxisome_Homo sapiens_hsa041461.32922188
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30633193
35Collecting duct acid secretion_Homo sapiens_hsa049661.30387679
36Regulation of autophagy_Homo sapiens_hsa041401.27587844
37Morphine addiction_Homo sapiens_hsa050321.20342039
38Mismatch repair_Homo sapiens_hsa034301.18776499
39Nitrogen metabolism_Homo sapiens_hsa009101.16907113
40Cardiac muscle contraction_Homo sapiens_hsa042601.15926673
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15510851
42Circadian entrainment_Homo sapiens_hsa047131.09856345
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.05740098
44Serotonergic synapse_Homo sapiens_hsa047261.03876340
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03691930
46Nucleotide excision repair_Homo sapiens_hsa034200.99745381
47Glutamatergic synapse_Homo sapiens_hsa047240.99269039
48Proteasome_Homo sapiens_hsa030500.96606332
49Folate biosynthesis_Homo sapiens_hsa007900.95226523
50Olfactory transduction_Homo sapiens_hsa047400.93229379
51Insulin secretion_Homo sapiens_hsa049110.91562548
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86228472
53Purine metabolism_Homo sapiens_hsa002300.85697873
54Cocaine addiction_Homo sapiens_hsa050300.84688328
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82879841
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81035047
57Dopaminergic synapse_Homo sapiens_hsa047280.80253886
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79849666
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79169275
60Caffeine metabolism_Homo sapiens_hsa002320.78056075
61Sulfur metabolism_Homo sapiens_hsa009200.77380301
62Retinol metabolism_Homo sapiens_hsa008300.75207342
63Metabolic pathways_Homo sapiens_hsa011000.74977675
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74960402
65Fatty acid elongation_Homo sapiens_hsa000620.74403786
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74203168
67Chemical carcinogenesis_Homo sapiens_hsa052040.73963484
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72788254
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72545988
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72158342
71Amphetamine addiction_Homo sapiens_hsa050310.67684511
72Pyrimidine metabolism_Homo sapiens_hsa002400.67038490
73Arachidonic acid metabolism_Homo sapiens_hsa005900.66988871
74One carbon pool by folate_Homo sapiens_hsa006700.64185345
75RNA transport_Homo sapiens_hsa030130.59323592
76Fatty acid degradation_Homo sapiens_hsa000710.59316643
77Long-term depression_Homo sapiens_hsa047300.57922635
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57312006
79Hedgehog signaling pathway_Homo sapiens_hsa043400.55968528
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55359807
81Fatty acid metabolism_Homo sapiens_hsa012120.53551037
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.53388601
83Circadian rhythm_Homo sapiens_hsa047100.53263735
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53003164
85beta-Alanine metabolism_Homo sapiens_hsa004100.51103448
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.50923204
87Synaptic vesicle cycle_Homo sapiens_hsa047210.50880602
88Base excision repair_Homo sapiens_hsa034100.49721528
89ABC transporters_Homo sapiens_hsa020100.47314347
90Pyruvate metabolism_Homo sapiens_hsa006200.42686515
91Glutathione metabolism_Homo sapiens_hsa004800.42430183
92Lysine degradation_Homo sapiens_hsa003100.40246010
93Salivary secretion_Homo sapiens_hsa049700.38990346
94Ovarian steroidogenesis_Homo sapiens_hsa049130.38469542
95Dorso-ventral axis formation_Homo sapiens_hsa043200.36048609
96Oocyte meiosis_Homo sapiens_hsa041140.35753007
97Cholinergic synapse_Homo sapiens_hsa047250.35049324
98Axon guidance_Homo sapiens_hsa043600.34072025
99Spliceosome_Homo sapiens_hsa030400.33994885
100Fat digestion and absorption_Homo sapiens_hsa049750.33521024

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