ZNF566

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.37762172
2behavioral response to nicotine (GO:0035095)4.23558082
3gamma-aminobutyric acid transport (GO:0015812)3.95442378
4neural tube formation (GO:0001841)3.57521868
5pyrimidine nucleobase catabolic process (GO:0006208)3.57244448
6DNA double-strand break processing (GO:0000729)3.54037579
7water-soluble vitamin biosynthetic process (GO:0042364)3.45280645
8fucose catabolic process (GO:0019317)3.44084967
9L-fucose metabolic process (GO:0042354)3.44084967
10L-fucose catabolic process (GO:0042355)3.44084967
11platelet dense granule organization (GO:0060155)3.37507318
12regulation of hexokinase activity (GO:1903299)3.30615766
13regulation of glucokinase activity (GO:0033131)3.30615766
14protein-cofactor linkage (GO:0018065)3.27490319
15nonmotile primary cilium assembly (GO:0035058)3.27169123
16DNA deamination (GO:0045006)3.16525074
17indolalkylamine metabolic process (GO:0006586)3.14627954
18replication fork processing (GO:0031297)3.12116730
19nucleobase catabolic process (GO:0046113)3.09541316
20negative regulation of telomere maintenance (GO:0032205)3.06542004
21respiratory chain complex IV assembly (GO:0008535)3.06009909
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00576917
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.00576917
24protein complex biogenesis (GO:0070271)2.96918929
25kynurenine metabolic process (GO:0070189)2.96417522
26protein polyglutamylation (GO:0018095)2.92592130
27cytochrome complex assembly (GO:0017004)2.92028487
28tryptophan catabolic process (GO:0006569)2.90662022
29indole-containing compound catabolic process (GO:0042436)2.90662022
30indolalkylamine catabolic process (GO:0046218)2.90662022
31negative regulation of transcription regulatory region DNA binding (GO:2000678)2.88036945
32piRNA metabolic process (GO:0034587)2.87256933
33epithelial cilium movement (GO:0003351)2.85706591
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84836161
35glycosphingolipid biosynthetic process (GO:0006688)2.81019498
36detection of light stimulus involved in sensory perception (GO:0050962)2.80116274
37detection of light stimulus involved in visual perception (GO:0050908)2.80116274
38negative regulation of DNA-dependent DNA replication (GO:2000104)2.80017430
39mitochondrial respiratory chain complex assembly (GO:0033108)2.79950493
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79894725
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79857480
42kidney morphogenesis (GO:0060993)2.78476040
43ubiquinone metabolic process (GO:0006743)2.78237710
44presynaptic membrane assembly (GO:0097105)2.78209090
45regulation of timing of cell differentiation (GO:0048505)2.76680452
46protein localization to cilium (GO:0061512)2.75667649
47preassembly of GPI anchor in ER membrane (GO:0016254)2.75538508
48cilium morphogenesis (GO:0060271)2.75156221
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74013005
50negative regulation of translation, ncRNA-mediated (GO:0040033)2.74013005
51regulation of translation, ncRNA-mediated (GO:0045974)2.74013005
52positive regulation of mitochondrial fission (GO:0090141)2.73969221
53protein K6-linked ubiquitination (GO:0085020)2.73946214
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72671792
55regulation of development, heterochronic (GO:0040034)2.72139638
56regulation of telomere maintenance (GO:0032204)2.71732235
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69711485
58neuronal action potential (GO:0019228)2.68147236
59ubiquinone biosynthetic process (GO:0006744)2.66885192
60spinal cord motor neuron differentiation (GO:0021522)2.66725178
61intraciliary transport (GO:0042073)2.66314776
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65176696
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.65176696
64NADH dehydrogenase complex assembly (GO:0010257)2.65176696
65C4-dicarboxylate transport (GO:0015740)2.64014712
66resolution of meiotic recombination intermediates (GO:0000712)2.63461734
67sulfation (GO:0051923)2.63317715
68limb bud formation (GO:0060174)2.61881643
69organelle disassembly (GO:1903008)2.61640008
70tryptophan metabolic process (GO:0006568)2.59877922
71regulation of nuclear cell cycle DNA replication (GO:0033262)2.59756921
72photoreceptor cell maintenance (GO:0045494)2.59649233
73recombinational repair (GO:0000725)2.59629976
74synapsis (GO:0007129)2.59390176
75cilium organization (GO:0044782)2.58133773
76axoneme assembly (GO:0035082)2.57015818
77double-strand break repair via homologous recombination (GO:0000724)2.56230769
78postsynaptic membrane organization (GO:0001941)2.53037275
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52305748
80cilium assembly (GO:0042384)2.51773241
81cornea development in camera-type eye (GO:0061303)2.51696709
82reciprocal DNA recombination (GO:0035825)2.49819660
83reciprocal meiotic recombination (GO:0007131)2.49819660
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48393829
85indole-containing compound metabolic process (GO:0042430)2.48264057
86photoreceptor cell development (GO:0042461)2.47317227
87anterograde synaptic vesicle transport (GO:0048490)2.47269496
88regulation of cilium movement (GO:0003352)2.46205135
89behavioral response to ethanol (GO:0048149)2.44128954
90somite development (GO:0061053)2.43512353
91head development (GO:0060322)2.42715901
92regulation of mesoderm development (GO:2000380)2.42124541
93regulation of hippo signaling (GO:0035330)2.41686300
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40524272
95retinal cone cell development (GO:0046549)2.40457686
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39092053
97protein K11-linked deubiquitination (GO:0035871)2.38281549
98presynaptic membrane organization (GO:0097090)2.37639027
99positive regulation of oligodendrocyte differentiation (GO:0048714)2.37566787
100positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.36438006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.00475178
2VDR_22108803_ChIP-Seq_LS180_Human3.22989490
3EZH2_22144423_ChIP-Seq_EOC_Human3.11423705
4GBX2_23144817_ChIP-Seq_PC3_Human2.97347549
5IGF1R_20145208_ChIP-Seq_DFB_Human2.80325650
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68778891
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63310577
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56778872
9TAF15_26573619_Chip-Seq_HEK293_Human2.46867865
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.35030576
11EWS_26573619_Chip-Seq_HEK293_Human2.28997936
12FUS_26573619_Chip-Seq_HEK293_Human2.28973314
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26481759
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25620496
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24214681
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14331887
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10503275
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.09544695
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08253429
20P300_19829295_ChIP-Seq_ESCs_Human2.05779682
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91544141
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85325214
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82196078
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.81542767
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77321447
26IRF1_19129219_ChIP-ChIP_H3396_Human1.75455568
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72521374
28* EST1_17652178_ChIP-ChIP_JURKAT_Human1.72424363
29ER_23166858_ChIP-Seq_MCF-7_Human1.70740365
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64404502
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59656562
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.58655830
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58505446
34MYC_18940864_ChIP-ChIP_HL60_Human1.56911034
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53603339
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52854899
37BCAT_22108803_ChIP-Seq_LS180_Human1.49536465
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49287780
39SMAD4_21799915_ChIP-Seq_A2780_Human1.47810197
40* NOTCH1_21737748_ChIP-Seq_TLL_Human1.47484175
41RNF2_27304074_Chip-Seq_NSC_Mouse1.46854705
42* STAT3_23295773_ChIP-Seq_U87_Human1.46453271
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45341706
44CBP_20019798_ChIP-Seq_JUKART_Human1.45341706
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.45118916
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44957839
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44080608
48ELK1_19687146_ChIP-ChIP_HELA_Human1.40945568
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39416227
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38724059
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38217246
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36486049
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.36414108
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34858708
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34858708
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34758574
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34045976
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32734993
59TP53_22573176_ChIP-Seq_HFKS_Human1.32655976
60AR_25329375_ChIP-Seq_VCAP_Human1.30835989
61TCF4_23295773_ChIP-Seq_U87_Human1.29900553
62REST_21632747_ChIP-Seq_MESCs_Mouse1.29646833
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27487865
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25540485
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23986189
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23447649
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23073679
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.21969461
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20516853
70TCF4_22108803_ChIP-Seq_LS180_Human1.17081933
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.15885115
72VDR_23849224_ChIP-Seq_CD4+_Human1.15379446
73RUNX2_22187159_ChIP-Seq_PCA_Human1.14178582
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.13412406
75SOX2_19829295_ChIP-Seq_ESCs_Human1.13247194
76NANOG_19829295_ChIP-Seq_ESCs_Human1.13247194
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12539217
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10713260
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08673825
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.07233134
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05553290
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05042720
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.05042720
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.03396721
85AR_21572438_ChIP-Seq_LNCaP_Human1.03364715
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03150123
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03079413
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01956205
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.01172138
90NCOR_22424771_ChIP-Seq_293T_Human1.01083558
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97922971
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97676919
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96773246
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96591914
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96455479
96EZH2_27304074_Chip-Seq_ESCs_Mouse0.96331758
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.96098191
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95294835
99P53_22387025_ChIP-Seq_ESCs_Mouse0.94931333
100* ETS1_20019798_ChIP-Seq_JURKAT_Human0.94762956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.93735620
2MP0002102_abnormal_ear_morphology2.89435533
3MP0008877_abnormal_DNA_methylation2.74414991
4MP0006292_abnormal_olfactory_placode2.72912707
5MP0003787_abnormal_imprinting2.27478225
6MP0001968_abnormal_touch/_nociception2.21373360
7MP0005551_abnormal_eye_electrophysiolog2.04757125
8MP0001986_abnormal_taste_sensitivity2.02159653
9MP0000569_abnormal_digit_pigmentation1.97933236
10MP0002736_abnormal_nociception_after1.96615149
11MP0006276_abnormal_autonomic_nervous1.94363300
12MP0005645_abnormal_hypothalamus_physiol1.93870554
13MP0002837_dystrophic_cardiac_calcinosis1.87881582
14MP0004133_heterotaxia1.85627863
15MP0008058_abnormal_DNA_repair1.83688429
16MP0009745_abnormal_behavioral_response1.80407047
17MP0009046_muscle_twitch1.79276822
18MP0001529_abnormal_vocalization1.79002318
19MP0003195_calcinosis1.78621764
20MP0003646_muscle_fatigue1.78545097
21MP0002735_abnormal_chemical_nociception1.77264156
22MP0004142_abnormal_muscle_tone1.75111225
23MP0000631_abnormal_neuroendocrine_gland1.74939205
24MP0006072_abnormal_retinal_apoptosis1.73756460
25MP0005423_abnormal_somatic_nervous1.68158931
26MP0003890_abnormal_embryonic-extraembry1.64984331
27MP0005646_abnormal_pituitary_gland1.61835340
28MP0002938_white_spotting1.60186813
29MP0002234_abnormal_pharynx_morphology1.59800995
30MP0002272_abnormal_nervous_system1.57179024
31MP0005253_abnormal_eye_physiology1.55204208
32MP0000427_abnormal_hair_cycle1.52580334
33MP0003122_maternal_imprinting1.51546081
34MP0001984_abnormal_olfaction1.50892692
35MP0003121_genomic_imprinting1.49188917
36MP0001188_hyperpigmentation1.47863140
37MP0003136_yellow_coat_color1.47130228
38MP0001486_abnormal_startle_reflex1.41683774
39MP0008872_abnormal_physiological_respon1.39389929
40MP0003635_abnormal_synaptic_transmissio1.37154538
41MP0002572_abnormal_emotion/affect_behav1.36763579
42MP0004043_abnormal_pH_regulation1.36544502
43MP0002557_abnormal_social/conspecific_i1.34882429
44MP0002638_abnormal_pupillary_reflex1.34257442
45MP0000778_abnormal_nervous_system1.32107853
46MP0003283_abnormal_digestive_organ1.31856375
47MP0004885_abnormal_endolymph1.30492367
48MP0008789_abnormal_olfactory_epithelium1.28410733
49MP0004147_increased_porphyrin_level1.26599593
50MP0005084_abnormal_gallbladder_morpholo1.25311918
51MP0002064_seizures1.24814295
52MP0002876_abnormal_thyroid_physiology1.24449744
53MP0002734_abnormal_mechanical_nocicepti1.23087696
54MP0002063_abnormal_learning/memory/cond1.21987002
55MP0003718_maternal_effect1.21788848
56MP0001485_abnormal_pinna_reflex1.19429547
57MP0004924_abnormal_behavior1.19419220
58MP0005386_behavior/neurological_phenoty1.19419220
59MP0002067_abnormal_sensory_capabilities1.19123396
60MP0002653_abnormal_ependyma_morphology1.17514854
61MP0000372_irregular_coat_pigmentation1.14270389
62MP0000049_abnormal_middle_ear1.13177922
63MP0002733_abnormal_thermal_nociception1.12707509
64MP0003119_abnormal_digestive_system1.11479238
65MP0003011_delayed_dark_adaptation1.10630847
66MP0003937_abnormal_limbs/digits/tail_de1.09681788
67MP0002751_abnormal_autonomic_nervous1.08818640
68MP0001501_abnormal_sleep_pattern1.07637849
69MP0001293_anophthalmia1.07482477
70MP0000647_abnormal_sebaceous_gland1.07138505
71MP0005187_abnormal_penis_morphology1.07124585
72MP0008995_early_reproductive_senescence1.06949592
73MP0001970_abnormal_pain_threshold1.06026562
74MP0002160_abnormal_reproductive_system1.04392685
75MP0008875_abnormal_xenobiotic_pharmacok1.04103092
76MP0002928_abnormal_bile_duct1.02873819
77MP0002184_abnormal_innervation1.01461192
78MP0003567_abnormal_fetal_cardiomyocyte0.99650731
79MP0004145_abnormal_muscle_electrophysio0.97632671
80MP0005379_endocrine/exocrine_gland_phen0.97352793
81MP0005499_abnormal_olfactory_system0.97092043
82MP0005394_taste/olfaction_phenotype0.97092043
83MP0005195_abnormal_posterior_eye0.95960145
84MP0005389_reproductive_system_phenotype0.95185723
85MP0000566_synostosis0.94788406
86MP0000383_abnormal_hair_follicle0.94727384
87MP0002752_abnormal_somatic_nervous0.93625512
88MP0003698_abnormal_male_reproductive0.93267186
89MP0001929_abnormal_gametogenesis0.89638906
90MP0004859_abnormal_synaptic_plasticity0.88066858
91MP0001905_abnormal_dopamine_level0.87666683
92MP0002210_abnormal_sex_determination0.87343336
93MP0004215_abnormal_myocardial_fiber0.85181251
94MP0000955_abnormal_spinal_cord0.83709752
95MP0004742_abnormal_vestibular_system0.83548826
96MP0003137_abnormal_impulse_conducting0.83534439
97MP0006035_abnormal_mitochondrial_morpho0.83321568
98MP0002163_abnormal_gland_morphology0.83180997
99MP0002095_abnormal_skin_pigmentation0.83130611
100MP0001919_abnormal_reproductive_system0.82660241

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.00874324
2Pancreatic fibrosis (HP:0100732)3.92352006
3True hermaphroditism (HP:0010459)3.68233121
4Abnormality of midbrain morphology (HP:0002418)3.61754504
5Molar tooth sign on MRI (HP:0002419)3.61754504
6Nephronophthisis (HP:0000090)3.35048490
7Hyperventilation (HP:0002883)3.31803118
8Medial flaring of the eyebrow (HP:0010747)3.18522839
9Congenital stationary night blindness (HP:0007642)2.89693670
10Abnormality of the renal medulla (HP:0100957)2.88680873
11Abnormality of the labia minora (HP:0012880)2.81557890
12Progressive inability to walk (HP:0002505)2.81118893
13Type II lissencephaly (HP:0007260)2.80745030
14Chronic hepatic failure (HP:0100626)2.78954635
15Gait imbalance (HP:0002141)2.77803666
16Inability to walk (HP:0002540)2.74472123
17Congenital primary aphakia (HP:0007707)2.63227545
18Abnormality of the renal cortex (HP:0011035)2.62538457
19Abnormal drinking behavior (HP:0030082)2.47162357
20Polydipsia (HP:0001959)2.47162357
21Nephrogenic diabetes insipidus (HP:0009806)2.47046796
22Attenuation of retinal blood vessels (HP:0007843)2.43130052
23Broad-based gait (HP:0002136)2.37986535
24Genital tract atresia (HP:0001827)2.37779558
25Lissencephaly (HP:0001339)2.35741091
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35217059
27Abnormality of alanine metabolism (HP:0010916)2.35217059
28Hyperalaninemia (HP:0003348)2.35217059
29Cystic liver disease (HP:0006706)2.34513823
30Colon cancer (HP:0003003)2.29059792
31Vaginal atresia (HP:0000148)2.28009803
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.27512475
33Anencephaly (HP:0002323)2.27406272
34Abolished electroretinogram (ERG) (HP:0000550)2.26553197
35Cerebellar dysplasia (HP:0007033)2.25571960
36Pendular nystagmus (HP:0012043)2.25476617
37Methylmalonic acidemia (HP:0002912)2.23411226
38Genetic anticipation (HP:0003743)2.20372081
39Febrile seizures (HP:0002373)2.18594895
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18530597
41Postaxial foot polydactyly (HP:0001830)2.15937323
42Abnormal rod and cone electroretinograms (HP:0008323)2.15779395
43Drooling (HP:0002307)2.15613010
44Hypothermia (HP:0002045)2.14851032
45Atonic seizures (HP:0010819)2.13869841
46Focal motor seizures (HP:0011153)2.11570780
47Oligodactyly (hands) (HP:0001180)2.11396500
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.11158057
49Sclerocornea (HP:0000647)2.10030679
50Intestinal atresia (HP:0011100)2.08184264
51Progressive cerebellar ataxia (HP:0002073)2.07993621
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.05739990
53Gaze-evoked nystagmus (HP:0000640)2.05670184
54Renal cortical cysts (HP:0000803)2.04651886
55Tubular atrophy (HP:0000092)2.01193696
56Small hand (HP:0200055)1.98196533
57Optic nerve hypoplasia (HP:0000609)1.97865410
58Concave nail (HP:0001598)1.97259097
59Large for gestational age (HP:0001520)1.93339937
60Poor coordination (HP:0002370)1.92245421
61Absent speech (HP:0001344)1.91918330
62Polyuria (HP:0000103)1.90626782
63Postaxial hand polydactyly (HP:0001162)1.90332877
64Excessive salivation (HP:0003781)1.90208855
65Methylmalonic aciduria (HP:0012120)1.89720190
66Birth length less than 3rd percentile (HP:0003561)1.89613820
67Congenital hepatic fibrosis (HP:0002612)1.88011206
68Decreased central vision (HP:0007663)1.87985235
69Protruding tongue (HP:0010808)1.87236531
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84565396
71Keratoconus (HP:0000563)1.84319844
72Increased corneal curvature (HP:0100692)1.84319844
73Abnormality of the ileum (HP:0001549)1.83629697
74Patellar aplasia (HP:0006443)1.83266496
75Limb dystonia (HP:0002451)1.82190996
76Male pseudohermaphroditism (HP:0000037)1.81887406
77Hyperglycinemia (HP:0002154)1.81627865
78Mitochondrial inheritance (HP:0001427)1.81008539
79Furrowed tongue (HP:0000221)1.80867242
80Increased CSF lactate (HP:0002490)1.80042844
81Meckel diverticulum (HP:0002245)1.79647834
82Acute necrotizing encephalopathy (HP:0006965)1.79638747
83Abnormality of the pons (HP:0007361)1.79544214
84Hemiparesis (HP:0001269)1.79293641
85Volvulus (HP:0002580)1.78923602
86Short tibia (HP:0005736)1.78524988
87Preaxial hand polydactyly (HP:0001177)1.78385618
88Dialeptic seizures (HP:0011146)1.75547300
89Focal seizures (HP:0007359)1.75519818
90Hypoplasia of the pons (HP:0012110)1.74511004
91Aplasia/Hypoplasia of the patella (HP:0006498)1.73860472
92Narrow forehead (HP:0000341)1.73278922
93Specific learning disability (HP:0001328)1.72965287
94Dyskinesia (HP:0100660)1.72515531
95Pachygyria (HP:0001302)1.71486251
96Supernumerary spleens (HP:0009799)1.71187211
97Retinal dysplasia (HP:0007973)1.70823198
98Dandy-Walker malformation (HP:0001305)1.70592824
99Astigmatism (HP:0000483)1.70276525
100Anophthalmia (HP:0000528)1.70108883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.85152887
2MAP3K42.87757605
3WNK32.87200347
4ADRBK22.84487688
5MAP4K22.68201785
6PINK12.49791268
7ZAK2.42939255
8CASK2.36840662
9TLK12.20082526
10BMPR1B2.19599130
11MAPK132.17746284
12NUAK12.16622571
13GRK12.04232528
14INSRR2.00190520
15MAP2K71.98406118
16MKNK21.85617058
17MARK11.76400797
18ACVR1B1.74740125
19TRIM281.72495883
20WNK41.70297823
21BCR1.63556989
22AKT31.54739746
23TAOK31.45637306
24OXSR11.44642002
25TNIK1.43175309
26STK391.38600380
27PAK31.31977918
28MKNK11.29795850
29DYRK21.29704389
30CSNK1G21.28861389
31BRSK21.25527747
32PLK41.21306264
33PRKCG1.20630875
34VRK11.14843647
35CSNK1G11.13479968
36PLK21.13209617
37STK38L1.12796411
38PNCK1.10237008
39CSNK1G31.10064539
40PRKCE1.01467650
41CAMKK20.99707530
42ERBB30.99019525
43CSNK1A1L0.98866165
44PLK30.98673672
45DAPK20.91609240
46BCKDK0.89995780
47EPHA40.89496636
48WEE10.84332599
49EIF2AK30.82847896
50PHKG20.81209883
51PHKG10.81209883
52SRPK10.78536837
53FGFR20.76597789
54LATS10.74965118
55MAP2K40.73348313
56CDC70.73087110
57ADRBK10.72520230
58EPHA30.70901082
59DYRK30.70421686
60TGFBR10.70408406
61MAPKAPK50.68374029
62PIK3CA0.68079333
63MAPKAPK30.67100058
64CAMK2A0.64149033
65STK30.61520891
66NTRK20.61285130
67PLK10.58516864
68TSSK60.57104073
69OBSCN0.56662392
70RPS6KA50.55918403
71BUB10.52745994
72PRKCI0.49694001
73SGK20.47806725
74MST40.46785684
75PKN10.45164128
76PRKAA10.44523212
77NEK10.43743380
78CDK30.43628040
79ATR0.43375267
80MAPK150.43373745
81NEK20.43349555
82RPS6KA40.43264365
83CDK190.41788136
84CHEK20.41251052
85PRKACA0.41217228
86SGK4940.41150730
87SGK2230.41150730
88PTK2B0.39622627
89TIE10.39245050
90NME10.39126598
91CSNK1A10.39061667
92ATM0.39011506
93CSNK1D0.37880829
94CCNB10.37311327
95CAMK10.36461011
96CAMK2B0.34892146
97NTRK30.33845924
98PRKG10.33602909
99CAMK40.33112042
100EIF2AK20.32949451

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.83565177
2Phototransduction_Homo sapiens_hsa047442.46935145
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45291490
4Protein export_Homo sapiens_hsa030602.42862247
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38948959
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32264569
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26296157
8Butanoate metabolism_Homo sapiens_hsa006502.15546363
9Basal transcription factors_Homo sapiens_hsa030222.15452738
10Oxidative phosphorylation_Homo sapiens_hsa001902.12291394
11Homologous recombination_Homo sapiens_hsa034402.02500119
12Fanconi anemia pathway_Homo sapiens_hsa034602.00861643
13Selenocompound metabolism_Homo sapiens_hsa004501.96476340
14RNA polymerase_Homo sapiens_hsa030201.94836110
15Propanoate metabolism_Homo sapiens_hsa006401.87534661
16Linoleic acid metabolism_Homo sapiens_hsa005911.86446522
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85927939
18Nitrogen metabolism_Homo sapiens_hsa009101.80854538
19Parkinsons disease_Homo sapiens_hsa050121.79051388
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78252972
21Taste transduction_Homo sapiens_hsa047421.78183428
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67551770
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62993647
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.62515056
25RNA degradation_Homo sapiens_hsa030181.61815410
26Tryptophan metabolism_Homo sapiens_hsa003801.53272151
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51229264
28Caffeine metabolism_Homo sapiens_hsa002321.44811639
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44529305
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41164621
31Morphine addiction_Homo sapiens_hsa050321.39480034
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38382943
33GABAergic synapse_Homo sapiens_hsa047271.37027445
34Steroid biosynthesis_Homo sapiens_hsa001001.31455130
35Non-homologous end-joining_Homo sapiens_hsa034501.29654368
36Ether lipid metabolism_Homo sapiens_hsa005651.25819384
37Regulation of autophagy_Homo sapiens_hsa041401.25492826
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18597411
39Olfactory transduction_Homo sapiens_hsa047401.18465764
40Huntingtons disease_Homo sapiens_hsa050161.16832720
41Cardiac muscle contraction_Homo sapiens_hsa042601.14444266
42Peroxisome_Homo sapiens_hsa041461.10138360
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06158052
44Glutamatergic synapse_Homo sapiens_hsa047241.04825759
45Circadian entrainment_Homo sapiens_hsa047131.04690635
46Alzheimers disease_Homo sapiens_hsa050101.03439493
47One carbon pool by folate_Homo sapiens_hsa006700.99923305
48Serotonergic synapse_Homo sapiens_hsa047260.98797617
49Insulin secretion_Homo sapiens_hsa049110.94225791
50Mismatch repair_Homo sapiens_hsa034300.91573113
51Sulfur relay system_Homo sapiens_hsa041220.89992548
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.87686275
53RNA transport_Homo sapiens_hsa030130.86855542
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83708484
55Purine metabolism_Homo sapiens_hsa002300.83233405
56ABC transporters_Homo sapiens_hsa020100.81772194
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80999127
58Chemical carcinogenesis_Homo sapiens_hsa052040.80861971
59Cocaine addiction_Homo sapiens_hsa050300.79659452
60Dopaminergic synapse_Homo sapiens_hsa047280.76230363
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.75613099
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73763961
63beta-Alanine metabolism_Homo sapiens_hsa004100.73672622
64Retinol metabolism_Homo sapiens_hsa008300.71433722
65Amphetamine addiction_Homo sapiens_hsa050310.71095635
66Nucleotide excision repair_Homo sapiens_hsa034200.70106871
67Pyrimidine metabolism_Homo sapiens_hsa002400.69996438
68Base excision repair_Homo sapiens_hsa034100.69502228
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69136657
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68641296
71Circadian rhythm_Homo sapiens_hsa047100.67880503
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.66251274
73Salivary secretion_Homo sapiens_hsa049700.66137639
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65580259
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65408190
76Collecting duct acid secretion_Homo sapiens_hsa049660.63860355
77Long-term depression_Homo sapiens_hsa047300.63837429
78Metabolic pathways_Homo sapiens_hsa011000.62106015
79Fatty acid elongation_Homo sapiens_hsa000620.60081689
80Proteasome_Homo sapiens_hsa030500.59439688
81Hedgehog signaling pathway_Homo sapiens_hsa043400.59294255
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58195541
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56831416
84Calcium signaling pathway_Homo sapiens_hsa040200.54780005
85Arachidonic acid metabolism_Homo sapiens_hsa005900.54694985
86Fatty acid metabolism_Homo sapiens_hsa012120.48740778
87Sulfur metabolism_Homo sapiens_hsa009200.48317284
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47808889
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47213634
90Ovarian steroidogenesis_Homo sapiens_hsa049130.46994827
91Glycerolipid metabolism_Homo sapiens_hsa005610.45166600
92Fat digestion and absorption_Homo sapiens_hsa049750.43713498
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40940531
94Basal cell carcinoma_Homo sapiens_hsa052170.37419077
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36077692
96Spliceosome_Homo sapiens_hsa030400.35826583
97Axon guidance_Homo sapiens_hsa043600.34896782
98Histidine metabolism_Homo sapiens_hsa003400.33667825
99Dorso-ventral axis formation_Homo sapiens_hsa043200.33643304
100Oocyte meiosis_Homo sapiens_hsa041140.33516764

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