ZNF565

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.44303553
2positive regulation of mitochondrial fission (GO:0090141)4.63089537
3gamma-aminobutyric acid transport (GO:0015812)4.57156126
4nucleobase catabolic process (GO:0046113)4.54476636
5water-soluble vitamin biosynthetic process (GO:0042364)4.50361919
6intraciliary transport (GO:0042073)4.14823074
7nonmotile primary cilium assembly (GO:0035058)4.14322947
8platelet dense granule organization (GO:0060155)4.10515107
9protein complex biogenesis (GO:0070271)4.06831945
10anterograde synaptic vesicle transport (GO:0048490)4.01130056
11DNA double-strand break processing (GO:0000729)3.72976870
12mitochondrial respiratory chain complex assembly (GO:0033108)3.69685405
13regulation of cilium movement (GO:0003352)3.61799632
14mannosylation (GO:0097502)3.59505245
15ubiquinone biosynthetic process (GO:0006744)3.59053974
16histone H2A acetylation (GO:0043968)3.56352720
17protein polyglutamylation (GO:0018095)3.49076875
18ubiquinone metabolic process (GO:0006743)3.46933987
19peptidyl-histidine modification (GO:0018202)3.42257216
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39600654
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.39600654
22NADH dehydrogenase complex assembly (GO:0010257)3.39600654
23detection of light stimulus involved in sensory perception (GO:0050962)3.37915132
24detection of light stimulus involved in visual perception (GO:0050908)3.37915132
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29981786
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27639954
27neurotransmitter-gated ion channel clustering (GO:0072578)3.26783696
28protein-cofactor linkage (GO:0018065)3.25314808
29behavioral response to nicotine (GO:0035095)3.24300289
30anterograde axon cargo transport (GO:0008089)3.23389425
31cilium morphogenesis (GO:0060271)3.21794920
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17786229
33regulation of hexokinase activity (GO:1903299)3.14210284
34regulation of glucokinase activity (GO:0033131)3.14210284
35protein localization to cilium (GO:0061512)3.13964896
36epithelial cilium movement (GO:0003351)3.12224416
37isoprenoid biosynthetic process (GO:0008299)3.11243082
38fucose catabolic process (GO:0019317)3.08831151
39L-fucose metabolic process (GO:0042354)3.08831151
40L-fucose catabolic process (GO:0042355)3.08831151
41keratinocyte development (GO:0003334)3.08597477
42pyrimidine dimer repair (GO:0006290)3.07617842
43iron-sulfur cluster assembly (GO:0016226)3.02380306
44metallo-sulfur cluster assembly (GO:0031163)3.02380306
45aldehyde catabolic process (GO:0046185)3.01804475
46respiratory chain complex IV assembly (GO:0008535)2.99007024
47cytochrome complex assembly (GO:0017004)2.98959447
48negative regulation of telomere maintenance (GO:0032205)2.97485418
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91016556
50regulation of mitochondrial fission (GO:0090140)2.85182761
51preassembly of GPI anchor in ER membrane (GO:0016254)2.82398399
52positive regulation of amino acid transport (GO:0051957)2.82273665
53quinone biosynthetic process (GO:1901663)2.81750933
54GPI anchor metabolic process (GO:0006505)2.79072093
55proteasome assembly (GO:0043248)2.77263357
56establishment of protein localization to mitochondrial membrane (GO:0090151)2.76412048
57neurofilament cytoskeleton organization (GO:0060052)2.75988569
58dopamine transport (GO:0015872)2.75531552
59regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.75521510
60cilium organization (GO:0044782)2.75140755
61cilium assembly (GO:0042384)2.74752238
62cullin deneddylation (GO:0010388)2.73270096
63chaperone-mediated protein transport (GO:0072321)2.72930483
64organelle disassembly (GO:1903008)2.70767737
65neural tube formation (GO:0001841)2.70307994
66neuron cell-cell adhesion (GO:0007158)2.69049348
67artery smooth muscle contraction (GO:0014824)2.68766345
68peptidyl-cysteine modification (GO:0018198)2.67863649
69glycosphingolipid biosynthetic process (GO:0006688)2.66405949
70axoneme assembly (GO:0035082)2.65118419
71response to pheromone (GO:0019236)2.64227498
72regulation of meiosis I (GO:0060631)2.63256771
73intracellular protein transmembrane import (GO:0044743)2.62048987
74olfactory bulb development (GO:0021772)2.60141664
75cellular biogenic amine catabolic process (GO:0042402)2.58735901
76amine catabolic process (GO:0009310)2.58735901
77GPI anchor biosynthetic process (GO:0006506)2.58033239
78single strand break repair (GO:0000012)2.55505325
79presynaptic membrane assembly (GO:0097105)2.55308187
80cilium movement (GO:0003341)2.54579875
81C-terminal protein lipidation (GO:0006501)2.53691330
82protein deneddylation (GO:0000338)2.51116897
83regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50011617
84resolution of meiotic recombination intermediates (GO:0000712)2.49958686
85dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.49951990
86C-terminal protein amino acid modification (GO:0018410)2.49513419
87tachykinin receptor signaling pathway (GO:0007217)2.48905288
88glycolipid biosynthetic process (GO:0009247)2.48314655
89negative regulation of cell aging (GO:0090344)2.47813816
90photoreceptor cell maintenance (GO:0045494)2.47719812
91vocalization behavior (GO:0071625)2.46520179
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46310532
93melanosome transport (GO:0032402)2.45191480
94regulation of mitotic spindle checkpoint (GO:1903504)2.44874472
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44874472
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43064876
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43064876
98base-excision repair, AP site formation (GO:0006285)2.42269035
99DNA damage response, detection of DNA damage (GO:0042769)2.42177953
100establishment of melanosome localization (GO:0032401)2.41474526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.69516169
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.35777872
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33724884
4IGF1R_20145208_ChIP-Seq_DFB_Human3.16409567
5GBX2_23144817_ChIP-Seq_PC3_Human3.09877756
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.07939002
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00775138
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95500697
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.86419025
10TAF15_26573619_Chip-Seq_HEK293_Human2.76876986
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75250971
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71712102
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64662445
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60389477
15VDR_22108803_ChIP-Seq_LS180_Human2.44176989
16ELK1_19687146_ChIP-ChIP_HELA_Human2.20785521
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.15990014
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15006547
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10125841
20FUS_26573619_Chip-Seq_HEK293_Human2.08798558
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00530224
22EWS_26573619_Chip-Seq_HEK293_Human2.00481498
23EZH2_22144423_ChIP-Seq_EOC_Human1.96445161
24VDR_23849224_ChIP-Seq_CD4+_Human1.93521924
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90251615
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.89567567
27* ETS1_20019798_ChIP-Seq_JURKAT_Human1.89308233
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85961279
29P300_19829295_ChIP-Seq_ESCs_Human1.85551216
30IRF1_19129219_ChIP-ChIP_H3396_Human1.78319772
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77121459
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71156585
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68598811
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68174734
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66923986
36CBP_20019798_ChIP-Seq_JUKART_Human1.66923986
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65453285
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56707273
39TP53_22573176_ChIP-Seq_HFKS_Human1.45765788
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43153783
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41997783
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.41263606
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39226837
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35943684
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35075692
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35035967
47AR_25329375_ChIP-Seq_VCAP_Human1.34603428
48MYC_18940864_ChIP-ChIP_HL60_Human1.33360965
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32699028
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.32694520
51SMAD4_21799915_ChIP-Seq_A2780_Human1.32342819
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30845455
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30252750
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30252750
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29217921
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27676185
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27304674
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27172770
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27036060
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24967060
61FOXP3_21729870_ChIP-Seq_TREG_Human1.23380883
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.22884205
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21170629
64ER_23166858_ChIP-Seq_MCF-7_Human1.20815017
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18769878
66GABP_19822575_ChIP-Seq_HepG2_Human1.14228794
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13307222
68STAT3_23295773_ChIP-Seq_U87_Human1.11112269
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11012051
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10817114
71DCP1A_22483619_ChIP-Seq_HELA_Human1.09870087
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09276284
73SOX2_19829295_ChIP-Seq_ESCs_Human1.09187444
74NANOG_19829295_ChIP-Seq_ESCs_Human1.09187444
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.09039501
76RNF2_27304074_Chip-Seq_NSC_Mouse1.08394364
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07089098
78BCAT_22108803_ChIP-Seq_LS180_Human1.06902226
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04872730
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04410317
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.03946863
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.03720722
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01669815
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01326198
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.01258944
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01176026
87NCOR_22424771_ChIP-Seq_293T_Human1.00005108
88TCF4_22108803_ChIP-Seq_LS180_Human0.99141773
89RUNX2_22187159_ChIP-Seq_PCA_Human0.98257779
90* TCF4_23295773_ChIP-Seq_U87_Human0.96698371
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.96569500
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95131936
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95050024
94HTT_18923047_ChIP-ChIP_STHdh_Human0.94024410
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.92453972
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92343617
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92039468
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.91914344
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89984854
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89443522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.07879530
2MP0003880_abnormal_central_pattern2.74941913
3MP0002638_abnormal_pupillary_reflex2.68167868
4MP0000372_irregular_coat_pigmentation2.63759022
5MP0001986_abnormal_taste_sensitivity2.57544873
6MP0008789_abnormal_olfactory_epithelium2.50594741
7MP0006292_abnormal_olfactory_placode2.45325949
8MP0001984_abnormal_olfaction2.43356971
9MP0005499_abnormal_olfactory_system2.38127919
10MP0005394_taste/olfaction_phenotype2.38127919
11MP0003195_calcinosis2.35386503
12MP0006276_abnormal_autonomic_nervous2.26862214
13MP0004147_increased_porphyrin_level2.24892940
14MP0002822_catalepsy2.23144709
15MP0003122_maternal_imprinting2.18750768
16MP0006072_abnormal_retinal_apoptosis2.15706788
17MP0002102_abnormal_ear_morphology2.13279444
18MP0009046_muscle_twitch2.09993434
19MP0008058_abnormal_DNA_repair2.01285016
20MP0005551_abnormal_eye_electrophysiolog2.01187594
21MP0003011_delayed_dark_adaptation1.92585982
22MP0004142_abnormal_muscle_tone1.87115575
23MP0003121_genomic_imprinting1.76319855
24MP0005253_abnormal_eye_physiology1.68090410
25MP0008875_abnormal_xenobiotic_pharmacok1.62875197
26MP0005645_abnormal_hypothalamus_physiol1.62623280
27MP0001486_abnormal_startle_reflex1.59915882
28MP0002736_abnormal_nociception_after1.59652813
29MP0003806_abnormal_nucleotide_metabolis1.58102764
30MP0002272_abnormal_nervous_system1.57931634
31MP0009745_abnormal_behavioral_response1.57814869
32MP0008877_abnormal_DNA_methylation1.57431757
33MP0000516_abnormal_urinary_system1.57168680
34MP0005367_renal/urinary_system_phenotyp1.57168680
35MP0000427_abnormal_hair_cycle1.56571150
36MP0003718_maternal_effect1.52556278
37MP0002837_dystrophic_cardiac_calcinosis1.51577868
38MP0001968_abnormal_touch/_nociception1.50985521
39MP0006054_spinal_hemorrhage1.49739250
40MP0002938_white_spotting1.49655925
41MP0002751_abnormal_autonomic_nervous1.48971636
42MP0005423_abnormal_somatic_nervous1.43849170
43MP0002735_abnormal_chemical_nociception1.35990778
44MP0001905_abnormal_dopamine_level1.34472044
45MP0000778_abnormal_nervous_system1.33987202
46MP0002557_abnormal_social/conspecific_i1.29504275
47MP0003787_abnormal_imprinting1.29146267
48MP0004133_heterotaxia1.28950557
49MP0008057_abnormal_DNA_replication1.28909088
50MP0006035_abnormal_mitochondrial_morpho1.28828420
51MP0000647_abnormal_sebaceous_gland1.27972621
52MP0002234_abnormal_pharynx_morphology1.22610454
53MP0000013_abnormal_adipose_tissue1.22257760
54MP0003635_abnormal_synaptic_transmissio1.21537656
55MP0010386_abnormal_urinary_bladder1.20784058
56MP0002572_abnormal_emotion/affect_behav1.18479265
57MP0009697_abnormal_copulation1.15906705
58MP0002653_abnormal_ependyma_morphology1.13834763
59MP0001485_abnormal_pinna_reflex1.12550154
60MP0002184_abnormal_innervation1.07662227
61MP0005646_abnormal_pituitary_gland1.06769914
62MP0001970_abnormal_pain_threshold1.06671066
63MP0000569_abnormal_digit_pigmentation1.05020539
64MP0002160_abnormal_reproductive_system1.04832003
65MP0001324_abnormal_eye_pigmentation1.02807436
66MP0002734_abnormal_mechanical_nocicepti1.02290313
67MP0002090_abnormal_vision1.02065470
68MP0002928_abnormal_bile_duct1.00605935
69MP0002063_abnormal_learning/memory/cond1.00599994
70MP0002233_abnormal_nose_morphology1.00117069
71MP0003137_abnormal_impulse_conducting0.99840272
72MP0005187_abnormal_penis_morphology0.96577093
73MP0006036_abnormal_mitochondrial_physio0.95705767
74MP0002064_seizures0.95080210
75MP0005220_abnormal_exocrine_pancreas0.94989191
76MP0000358_abnormal_cell_content/0.93809778
77MP0000631_abnormal_neuroendocrine_gland0.93718511
78MP0001929_abnormal_gametogenesis0.93084517
79MP0002752_abnormal_somatic_nervous0.91883582
80MP0008872_abnormal_physiological_respon0.91715401
81MP0005386_behavior/neurological_phenoty0.91372351
82MP0004924_abnormal_behavior0.91372351
83MP0004811_abnormal_neuron_physiology0.90623061
84MP0003252_abnormal_bile_duct0.90002348
85MP0002277_abnormal_respiratory_mucosa0.89422420
86MP0004270_analgesia0.88614158
87MP0003938_abnormal_ear_development0.88529569
88MP0005075_abnormal_melanosome_morpholog0.88370126
89MP0000015_abnormal_ear_pigmentation0.86138685
90MP0002882_abnormal_neuron_morphology0.84781887
91MP0002067_abnormal_sensory_capabilities0.83843221
92MP0002282_abnormal_trachea_morphology0.83217169
93MP0000049_abnormal_middle_ear0.81691703
94MP0004085_abnormal_heartbeat0.80873642
95MP0005332_abnormal_amino_acid0.79322851
96MP0005195_abnormal_posterior_eye0.78319952
97MP0005084_abnormal_gallbladder_morpholo0.77732270
98MP0003698_abnormal_male_reproductive0.75777490
99MP0005389_reproductive_system_phenotype0.74845970
100MP0002163_abnormal_gland_morphology0.74534453

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)4.65615672
2Gait imbalance (HP:0002141)4.38933609
3Congenital primary aphakia (HP:0007707)4.27245834
4Nephrogenic diabetes insipidus (HP:0009806)4.22013725
5Pancreatic cysts (HP:0001737)4.05487690
6True hermaphroditism (HP:0010459)4.05228200
7Pancreatic fibrosis (HP:0100732)4.04026167
8Hyperventilation (HP:0002883)3.33469613
9Acute necrotizing encephalopathy (HP:0006965)3.33104975
10Vaginal atresia (HP:0000148)3.24178135
11Genital tract atresia (HP:0001827)3.23308444
12Methylmalonic acidemia (HP:0002912)3.18711168
13Polyphagia (HP:0002591)3.17836542
14Abnormal mitochondria in muscle tissue (HP:0008316)3.15140274
15Acute encephalopathy (HP:0006846)3.12527834
16Progressive macrocephaly (HP:0004481)3.07400062
17Hypothermia (HP:0002045)3.07150920
18Poor coordination (HP:0002370)3.03013006
19Abnormality of midbrain morphology (HP:0002418)2.92918875
20Molar tooth sign on MRI (HP:0002419)2.92918875
21Hyperglycinemia (HP:0002154)2.90207602
22Mitochondrial inheritance (HP:0001427)2.85719018
23Increased CSF lactate (HP:0002490)2.82616000
24Absent speech (HP:0001344)2.72559091
25Hepatocellular necrosis (HP:0001404)2.71035780
26Hepatic necrosis (HP:0002605)2.70787380
27Lissencephaly (HP:0001339)2.64628992
28Specific learning disability (HP:0001328)2.62897309
29Nephronophthisis (HP:0000090)2.61515365
30Methylmalonic aciduria (HP:0012120)2.59478576
31Cystic liver disease (HP:0006706)2.56277784
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.48822618
33Microvesicular hepatic steatosis (HP:0001414)2.48620012
34Optic disc pallor (HP:0000543)2.46493365
35Abolished electroretinogram (ERG) (HP:0000550)2.39803716
36Sclerocornea (HP:0000647)2.36594254
37Attenuation of retinal blood vessels (HP:0007843)2.34443715
38Abnormality of the labia minora (HP:0012880)2.34237510
39Pendular nystagmus (HP:0012043)2.31991318
40Anencephaly (HP:0002323)2.30109899
41Decreased testicular size (HP:0008734)2.23786144
42Abnormal protein glycosylation (HP:0012346)2.22763247
43Abnormal glycosylation (HP:0012345)2.22763247
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22763247
45Abnormal protein N-linked glycosylation (HP:0012347)2.22763247
46Aplasia/Hypoplasia of the lens (HP:0008063)2.22379440
47Cortical dysplasia (HP:0002539)2.21664387
48Hypoplastic pelvis (HP:0008839)2.21301730
49Occipital encephalocele (HP:0002085)2.19693589
50Tubulointerstitial nephritis (HP:0001970)2.19622961
51Pachygyria (HP:0001302)2.19107998
52Abnormality of the fovea (HP:0000493)2.17974215
53Increased serum lactate (HP:0002151)2.16403333
54Broad foot (HP:0001769)2.14572407
55Postaxial hand polydactyly (HP:0001162)2.13658180
56Abnormality of the renal medulla (HP:0100957)2.12952142
57Increased hepatocellular lipid droplets (HP:0006565)2.10668098
58Abnormality of vitamin B metabolism (HP:0004340)2.08544488
59Failure to thrive in infancy (HP:0001531)2.08444280
60Retinitis pigmentosa (HP:0000510)2.05805351
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05349917
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05349917
63Abnormal drinking behavior (HP:0030082)2.03629190
64Polydipsia (HP:0001959)2.03629190
65Congenital hepatic fibrosis (HP:0002612)2.03597267
66Retinal dysplasia (HP:0007973)2.01427513
67Abnormality of the vitamin B12 metabolism (HP:0004341)2.00809804
68Lipid accumulation in hepatocytes (HP:0006561)1.99285752
69Male pseudohermaphroditism (HP:0000037)1.98269609
70Type II lissencephaly (HP:0007260)1.97459015
71Abnormality of placental membranes (HP:0011409)1.93594404
72Amniotic constriction ring (HP:0009775)1.93594404
73Limb dystonia (HP:0002451)1.92745653
74Astigmatism (HP:0000483)1.92274750
75Drooling (HP:0002307)1.91677096
76Postaxial foot polydactyly (HP:0001830)1.86602108
77Aganglionic megacolon (HP:0002251)1.84743142
78Preaxial hand polydactyly (HP:0001177)1.83310338
79Muscular hypotonia of the trunk (HP:0008936)1.82935815
80Cerebral edema (HP:0002181)1.82408465
81Volvulus (HP:0002580)1.80803600
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.80278548
83Hypoplasia of the fovea (HP:0007750)1.80278548
84Narrow forehead (HP:0000341)1.80059898
85Short foot (HP:0001773)1.79890637
863-Methylglutaconic aciduria (HP:0003535)1.79472068
87Abnormal rod and cone electroretinograms (HP:0008323)1.77121533
88Bony spicule pigmentary retinopathy (HP:0007737)1.76867961
89Dyskinesia (HP:0100660)1.76562553
90Lactic acidosis (HP:0003128)1.75503981
91Small hand (HP:0200055)1.75445929
92Progressive cerebellar ataxia (HP:0002073)1.75262432
93Exercise intolerance (HP:0003546)1.74914178
94Hypomagnesemia (HP:0002917)1.74171468
95Abnormal biliary tract physiology (HP:0012439)1.73685170
96Bile duct proliferation (HP:0001408)1.73685170
97Furrowed tongue (HP:0000221)1.71587686
98Atonic seizures (HP:0010819)1.70940643
99Hemiparesis (HP:0001269)1.69435208
100Abnormality of the renal cortex (HP:0011035)1.68854824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.07174785
2TRIM283.97033639
3FRK3.18115393
4CASK3.09128052
5BCR3.07671347
6MARK12.67298006
7DYRK32.48718382
8ERBB32.34393026
9PAK32.08386806
10SRPK12.07498402
11INSRR1.96039654
12MAPK131.89639271
13MST41.89557358
14MAP3K41.77984912
15PINK11.66424653
16BCKDK1.64994553
17STK391.64001332
18CSNK1G21.60680092
19DYRK21.60581644
20CSNK1G11.60165000
21FER1.58405044
22GRK11.57529692
23CSNK1G31.55623323
24NUAK11.45339889
25OXSR11.39639606
26EPHA31.38519408
27EIF2AK31.38451392
28CSNK1A1L1.33694536
29MAP4K21.33099490
30ADRBK21.30960952
31EPHA41.30520593
32BMPR1B1.27260079
33CCNB11.23432244
34CDK191.23130178
35TSSK61.15975962
36MAP2K71.15043357
37STK161.14852718
38ZAK1.11735839
39ACVR1B1.07130202
40PLK21.06140729
41RPS6KA41.05881115
42PRKCG0.98526823
43PRKCE0.98220200
44STK38L0.92499420
45PRKCI0.90677057
46DYRK1A0.89417137
47MKNK20.88150890
48PLK30.83711043
49MAP3K120.82514188
50MUSK0.81906218
51BRD40.78775273
52PHKG10.76667414
53PHKG20.76667414
54SIK30.75748996
55TAOK30.74087011
56EIF2AK10.70749108
57CDK80.68821547
58NEK10.68401665
59PAK60.68096264
60NTRK30.66885664
61NME10.65986966
62BUB10.62736890
63MINK10.62077794
64RPS6KA50.60352826
65MKNK10.59873792
66PLK10.58117893
67VRK10.55223327
68CAMK2A0.54739690
69PKN10.53605416
70CSNK1A10.50469930
71FGFR20.47327433
72OBSCN0.45764213
73PRKACB0.44640053
74CAMK2D0.44510458
75WNK40.44175667
76CDK140.43719896
77RAF10.41488161
78ABL20.40427280
79SGK4940.40127530
80SGK2230.40127530
81MAPKAPK30.38393425
82CAMK2G0.38361581
83CSNK2A10.36805287
84CAMK2B0.35986940
85PRKACA0.35976015
86PRKCZ0.35783963
87CDK30.34920331
88GRK50.34809583
89LIMK10.33878845
90TIE10.32963279
91PAK10.32003868
92CSNK1D0.30967933
93NTRK20.30963572
94BRSK20.30922889
95DAPK10.30795290
96ABL10.30492737
97CDK50.29120319
98GSK3A0.28933137
99FLT30.28695052
100CDK180.27222020

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.56662577
2Oxidative phosphorylation_Homo sapiens_hsa001903.31364609
3Parkinsons disease_Homo sapiens_hsa050122.75050169
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.72336193
5Fatty acid elongation_Homo sapiens_hsa000622.68550774
6Proteasome_Homo sapiens_hsa030502.51361326
7Steroid biosynthesis_Homo sapiens_hsa001002.42050639
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40876981
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.35023808
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33531693
11RNA polymerase_Homo sapiens_hsa030202.16536547
12Sulfur relay system_Homo sapiens_hsa041222.08111111
13RNA degradation_Homo sapiens_hsa030181.99361464
14Butanoate metabolism_Homo sapiens_hsa006501.97717071
15Collecting duct acid secretion_Homo sapiens_hsa049661.91108983
16Huntingtons disease_Homo sapiens_hsa050161.86767894
17Nicotine addiction_Homo sapiens_hsa050331.85614907
18Regulation of autophagy_Homo sapiens_hsa041401.69346202
19Alzheimers disease_Homo sapiens_hsa050101.67679540
20Basal transcription factors_Homo sapiens_hsa030221.65498288
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64092416
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59175162
23Folate biosynthesis_Homo sapiens_hsa007901.50726500
24Phototransduction_Homo sapiens_hsa047441.46735685
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44503587
26Peroxisome_Homo sapiens_hsa041461.42517430
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.42086076
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39907781
29Fanconi anemia pathway_Homo sapiens_hsa034601.37829538
30Sulfur metabolism_Homo sapiens_hsa009201.36472313
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34682166
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33357275
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33228662
34GABAergic synapse_Homo sapiens_hsa047271.31078219
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28008569
36Circadian rhythm_Homo sapiens_hsa047101.23366329
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.22969871
38Cardiac muscle contraction_Homo sapiens_hsa042601.18855075
39Propanoate metabolism_Homo sapiens_hsa006401.18564502
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16503612
41Homologous recombination_Homo sapiens_hsa034401.12763818
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09111350
43Ether lipid metabolism_Homo sapiens_hsa005651.02305663
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97151458
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93176759
46Vitamin B6 metabolism_Homo sapiens_hsa007500.91512830
47Synaptic vesicle cycle_Homo sapiens_hsa047210.90605835
48Taste transduction_Homo sapiens_hsa047420.90358682
49Chemical carcinogenesis_Homo sapiens_hsa052040.90282155
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89887488
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88374832
52Vibrio cholerae infection_Homo sapiens_hsa051100.87306737
53Selenocompound metabolism_Homo sapiens_hsa004500.86859587
54Pyrimidine metabolism_Homo sapiens_hsa002400.85964485
55Purine metabolism_Homo sapiens_hsa002300.85553444
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84267227
57Metabolic pathways_Homo sapiens_hsa011000.81595574
58RNA transport_Homo sapiens_hsa030130.80806338
59Non-homologous end-joining_Homo sapiens_hsa034500.79033815
60Morphine addiction_Homo sapiens_hsa050320.78421774
61Tryptophan metabolism_Homo sapiens_hsa003800.76631842
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74613915
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74381712
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74063361
65Glutamatergic synapse_Homo sapiens_hsa047240.73728654
66Oocyte meiosis_Homo sapiens_hsa041140.73709340
67Circadian entrainment_Homo sapiens_hsa047130.67639158
68Spliceosome_Homo sapiens_hsa030400.67287893
69beta-Alanine metabolism_Homo sapiens_hsa004100.66137369
70Fatty acid metabolism_Homo sapiens_hsa012120.64597148
71Base excision repair_Homo sapiens_hsa034100.63445995
72Nucleotide excision repair_Homo sapiens_hsa034200.59680209
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58373405
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.58148636
75Dorso-ventral axis formation_Homo sapiens_hsa043200.54121471
76Serotonergic synapse_Homo sapiens_hsa047260.53984879
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.53790376
78Nitrogen metabolism_Homo sapiens_hsa009100.53772905
79Retinol metabolism_Homo sapiens_hsa008300.53489448
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52774418
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52725222
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52477142
83Dopaminergic synapse_Homo sapiens_hsa047280.52435917
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51744206
85Amphetamine addiction_Homo sapiens_hsa050310.50115961
86Caffeine metabolism_Homo sapiens_hsa002320.49227246
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49034940
88Insulin secretion_Homo sapiens_hsa049110.47967442
89Glutathione metabolism_Homo sapiens_hsa004800.45478507
90One carbon pool by folate_Homo sapiens_hsa006700.42558261
91Linoleic acid metabolism_Homo sapiens_hsa005910.41142909
92Mismatch repair_Homo sapiens_hsa034300.38895639
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36961780
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36497882
95Fatty acid degradation_Homo sapiens_hsa000710.36463416
96Sphingolipid metabolism_Homo sapiens_hsa006000.36059227
97N-Glycan biosynthesis_Homo sapiens_hsa005100.35643158
98Arginine and proline metabolism_Homo sapiens_hsa003300.34522325
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33486818
100Hedgehog signaling pathway_Homo sapiens_hsa043400.27128713

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