ZNF563

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.71042906
2positive regulation of prostaglandin secretion (GO:0032308)4.28376640
3behavioral response to nicotine (GO:0035095)4.15000944
4water-soluble vitamin biosynthetic process (GO:0042364)3.94968858
5cellular ketone body metabolic process (GO:0046950)3.90004886
6DNA deamination (GO:0045006)3.84724929
7platelet dense granule organization (GO:0060155)3.71724383
8ketone body metabolic process (GO:1902224)3.68841096
9L-fucose catabolic process (GO:0042355)3.66631184
10fucose catabolic process (GO:0019317)3.66631184
11L-fucose metabolic process (GO:0042354)3.66631184
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61983241
13protein import into peroxisome matrix (GO:0016558)3.61559737
14positive regulation of fatty acid transport (GO:2000193)3.57466960
15regulation of cilium movement (GO:0003352)3.56017175
16piRNA metabolic process (GO:0034587)3.44471053
17regulation of prostaglandin secretion (GO:0032306)3.43730206
18respiratory chain complex IV assembly (GO:0008535)3.40609232
19indolalkylamine metabolic process (GO:0006586)3.36056977
20positive regulation of icosanoid secretion (GO:0032305)3.32037991
21protein complex biogenesis (GO:0070271)3.30149699
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26630463
23photoreceptor cell maintenance (GO:0045494)3.25193310
24protein prenylation (GO:0018342)3.17867156
25prenylation (GO:0097354)3.17867156
26axoneme assembly (GO:0035082)3.16087446
27nonmotile primary cilium assembly (GO:0035058)3.14892504
28tryptophan metabolic process (GO:0006568)3.12653594
29detection of light stimulus involved in sensory perception (GO:0050962)3.09854378
30detection of light stimulus involved in visual perception (GO:0050908)3.09854378
31epithelial cilium movement (GO:0003351)3.09408322
32protein polyglutamylation (GO:0018095)3.07077470
33NADH dehydrogenase complex assembly (GO:0010257)3.05628610
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05628610
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.05628610
36protein K11-linked deubiquitination (GO:0035871)3.04680413
37mitochondrial respiratory chain complex assembly (GO:0033108)3.04121794
38indole-containing compound catabolic process (GO:0042436)3.03803690
39indolalkylamine catabolic process (GO:0046218)3.03803690
40tryptophan catabolic process (GO:0006569)3.03803690
41protein localization to peroxisome (GO:0072662)3.01436551
42protein targeting to peroxisome (GO:0006625)3.01436551
43establishment of protein localization to peroxisome (GO:0072663)3.01436551
44cytochrome complex assembly (GO:0017004)2.99532476
45negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98773851
46DNA methylation involved in gamete generation (GO:0043046)2.96986222
47protein-cofactor linkage (GO:0018065)2.96001768
48mannosylation (GO:0097502)2.95714270
49kidney morphogenesis (GO:0060993)2.91174471
50S-adenosylmethionine metabolic process (GO:0046500)2.90634510
51preassembly of GPI anchor in ER membrane (GO:0016254)2.86701069
52kynurenine metabolic process (GO:0070189)2.83496849
53glucosamine-containing compound catabolic process (GO:1901072)2.82614283
54reflex (GO:0060004)2.82429358
55adenosine metabolic process (GO:0046085)2.80734409
56replication fork processing (GO:0031297)2.77419829
57regulation of meiosis I (GO:0060631)2.76183797
58anterograde synaptic vesicle transport (GO:0048490)2.72267207
59rhodopsin mediated signaling pathway (GO:0016056)2.72100153
60ubiquinone biosynthetic process (GO:0006744)2.71733218
61regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70478516
62intracellular protein transmembrane import (GO:0044743)2.70339215
63GPI anchor metabolic process (GO:0006505)2.66121312
64aggressive behavior (GO:0002118)2.66006531
65regulation of memory T cell differentiation (GO:0043380)2.63899752
66synapsis (GO:0007129)2.62588804
67oligosaccharide catabolic process (GO:0009313)2.61665467
68retinal cone cell development (GO:0046549)2.60342132
69regulation of action potential (GO:0098900)2.60220181
70cilium morphogenesis (GO:0060271)2.58901494
71regulation of glucokinase activity (GO:0033131)2.57652776
72regulation of hexokinase activity (GO:1903299)2.57652776
73auditory receptor cell stereocilium organization (GO:0060088)2.54593948
74negative regulation of alpha-beta T cell differentiation (GO:0046639)2.54286536
75inositol phosphate catabolic process (GO:0071545)2.54121986
76neuronal action potential (GO:0019228)2.53664478
77photoreceptor cell development (GO:0042461)2.52192680
78cilium movement (GO:0003341)2.52022902
79cornea development in camera-type eye (GO:0061303)2.51553697
80heme transport (GO:0015886)2.51266421
81indole-containing compound metabolic process (GO:0042430)2.49790560
82response to dietary excess (GO:0002021)2.49000609
83oxidative demethylation (GO:0070989)2.48832796
84cilium or flagellum-dependent cell motility (GO:0001539)2.48585657
85peroxisomal transport (GO:0043574)2.48028974
86ubiquinone metabolic process (GO:0006743)2.46891072
87estrogen biosynthetic process (GO:0006703)2.46146110
88nephron epithelium morphogenesis (GO:0072088)2.46139978
89nephron tubule morphogenesis (GO:0072078)2.46139978
90dentate gyrus development (GO:0021542)2.44919138
91amine catabolic process (GO:0009310)2.44018043
92cellular biogenic amine catabolic process (GO:0042402)2.44018043
93regulation of microtubule-based movement (GO:0060632)2.43108505
94regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.41577083
95drug catabolic process (GO:0042737)2.39993266
96parental behavior (GO:0060746)2.39764505
97cilium organization (GO:0044782)2.39224980
98aromatic amino acid family catabolic process (GO:0009074)2.38735046
99positive regulation of organic acid transport (GO:0032892)2.38688083
100C-terminal protein lipidation (GO:0006501)2.38547476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.78101842
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.59058899
3VDR_22108803_ChIP-Seq_LS180_Human3.00396776
4GBX2_23144817_ChIP-Seq_PC3_Human2.68457071
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63714133
6IGF1R_20145208_ChIP-Seq_DFB_Human2.61867420
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53077265
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53044735
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.48755373
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.47414506
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42403858
12* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21074608
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10631210
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98422033
15FUS_26573619_Chip-Seq_HEK293_Human1.97249160
16P300_19829295_ChIP-Seq_ESCs_Human1.96230476
17EWS_26573619_Chip-Seq_HEK293_Human1.96204521
18TAF15_26573619_Chip-Seq_HEK293_Human1.91192152
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.87464153
20ER_23166858_ChIP-Seq_MCF-7_Human1.83602730
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83421016
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81642301
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78548378
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.77523235
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75564942
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71932404
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62338812
28IRF1_19129219_ChIP-ChIP_H3396_Human1.62215773
29BCAT_22108803_ChIP-Seq_LS180_Human1.59815078
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58230678
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57729255
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54719914
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51606485
34SMAD4_21799915_ChIP-Seq_A2780_Human1.50309445
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48107704
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.47915262
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46885085
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46569857
39STAT3_23295773_ChIP-Seq_U87_Human1.45598225
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45305456
41AR_25329375_ChIP-Seq_VCAP_Human1.43698451
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43019611
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.41759628
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.41596986
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.41253064
46EZH2_22144423_ChIP-Seq_EOC_Human1.40328472
47VDR_23849224_ChIP-Seq_CD4+_Human1.40279488
48NANOG_19829295_ChIP-Seq_ESCs_Human1.39201030
49SOX2_19829295_ChIP-Seq_ESCs_Human1.39201030
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39135439
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37993077
52MYC_18940864_ChIP-ChIP_HL60_Human1.37053116
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37051341
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.37051341
55TCF4_23295773_ChIP-Seq_U87_Human1.36621613
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34747055
57TP53_22573176_ChIP-Seq_HFKS_Human1.32473270
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32368140
59CBP_20019798_ChIP-Seq_JUKART_Human1.29513400
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29513400
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29314150
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.28627575
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28116191
64TCF4_22108803_ChIP-Seq_LS180_Human1.25708751
65* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25205831
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24508247
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24490032
68ELK1_19687146_ChIP-ChIP_HELA_Human1.24443653
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21710891
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.21072249
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19015773
72RUNX2_22187159_ChIP-Seq_PCA_Human1.18536033
73P53_22387025_ChIP-Seq_ESCs_Mouse1.18186531
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18154302
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17578628
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.17195390
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.16239372
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15183188
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15021063
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.14362927
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14311690
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14311690
83* AR_20517297_ChIP-Seq_VCAP_Human1.14239992
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.12277185
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12029200
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10319721
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.10290214
88NCOR_22424771_ChIP-Seq_293T_Human1.09661716
89CDX2_22108803_ChIP-Seq_LS180_Human1.09329391
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.08833175
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.06569432
92ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05886141
93P300_18555785_Chip-Seq_ESCs_Mouse1.05570886
94HTT_18923047_ChIP-ChIP_STHdh_Human1.04012886
95HOXB7_26014856_ChIP-Seq_BT474_Human1.01624177
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01411944
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00951447
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.00438092
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97719612
100RNF2_27304074_Chip-Seq_NSC_Mouse0.96850768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.60239021
2MP0002102_abnormal_ear_morphology2.92064500
3MP0008877_abnormal_DNA_methylation2.88933104
4MP0006292_abnormal_olfactory_placode2.75796043
5MP0005551_abnormal_eye_electrophysiolog2.60078872
6MP0006072_abnormal_retinal_apoptosis2.59261856
7MP0000569_abnormal_digit_pigmentation2.54068615
8MP0003787_abnormal_imprinting2.49702856
9MP0002638_abnormal_pupillary_reflex2.34135466
10MP0005253_abnormal_eye_physiology2.26870989
11MP0005646_abnormal_pituitary_gland2.23070131
12MP0002837_dystrophic_cardiac_calcinosis2.23033045
13MP0005174_abnormal_tail_pigmentation2.14481054
14MP0002876_abnormal_thyroid_physiology2.06957857
15MP0004142_abnormal_muscle_tone2.02386752
16MP0000015_abnormal_ear_pigmentation1.98931287
17MP0001968_abnormal_touch/_nociception1.97516523
18MP0000372_irregular_coat_pigmentation1.85822493
19MP0002938_white_spotting1.83994905
20MP0005075_abnormal_melanosome_morpholog1.83429249
21MP0008875_abnormal_xenobiotic_pharmacok1.82566390
22MP0001984_abnormal_olfaction1.82003668
23MP0001485_abnormal_pinna_reflex1.78011978
24MP0009046_muscle_twitch1.73545183
25MP0005645_abnormal_hypothalamus_physiol1.70065515
26MP0003252_abnormal_bile_duct1.65059006
27MP0001986_abnormal_taste_sensitivity1.63315663
28MP0003646_muscle_fatigue1.61751266
29MP0002736_abnormal_nociception_after1.58984029
30MP0002254_reproductive_system_inflammat1.56636537
31MP0008872_abnormal_physiological_respon1.54274823
32MP0004885_abnormal_endolymph1.52803865
33MP0003011_delayed_dark_adaptation1.48232094
34MP0002909_abnormal_adrenal_gland1.45237816
35MP0006276_abnormal_autonomic_nervous1.41329170
36MP0003121_genomic_imprinting1.39846812
37MP0000371_diluted_coat_color1.38327395
38MP0003136_yellow_coat_color1.38013597
39MP0009745_abnormal_behavioral_response1.37350182
40MP0001501_abnormal_sleep_pattern1.37282076
41MP0002095_abnormal_skin_pigmentation1.36973564
42MP0000631_abnormal_neuroendocrine_gland1.35171492
43MP0002928_abnormal_bile_duct1.33314807
44MP0005084_abnormal_gallbladder_morpholo1.32033435
45MP0002163_abnormal_gland_morphology1.31591250
46MP0005379_endocrine/exocrine_gland_phen1.31168362
47MP0005408_hypopigmentation1.29731305
48MP0010386_abnormal_urinary_bladder1.29309670
49MP0010329_abnormal_lipoprotein_level1.26960156
50MP0000427_abnormal_hair_cycle1.26278136
51MP0001486_abnormal_startle_reflex1.24354002
52MP0002160_abnormal_reproductive_system1.23835805
53MP0004043_abnormal_pH_regulation1.23726061
54MP0002272_abnormal_nervous_system1.18909743
55MP0005389_reproductive_system_phenotype1.17041726
56MP0005365_abnormal_bile_salt1.16084696
57MP0003718_maternal_effect1.14618024
58MP0008789_abnormal_olfactory_epithelium1.13291236
59MP0008058_abnormal_DNA_repair1.13062106
60MP0002557_abnormal_social/conspecific_i1.07586487
61MP0003122_maternal_imprinting1.07197862
62MP0005332_abnormal_amino_acid1.04989421
63MP0005085_abnormal_gallbladder_physiolo1.04169326
64MP0004742_abnormal_vestibular_system1.01175404
65MP0001963_abnormal_hearing_physiology1.01037218
66MP0000639_abnormal_adrenal_gland1.00430290
67MP0005195_abnormal_posterior_eye0.99936223
68MP0005377_hearing/vestibular/ear_phenot0.98900907
69MP0003878_abnormal_ear_physiology0.98900907
70MP0003880_abnormal_central_pattern0.98896987
71MP0005499_abnormal_olfactory_system0.95932154
72MP0005394_taste/olfaction_phenotype0.95932154
73MP0004133_heterotaxia0.94965816
74MP0001919_abnormal_reproductive_system0.94744043
75MP0005391_vision/eye_phenotype0.94312026
76MP0008775_abnormal_heart_ventricle0.94184272
77MP0001764_abnormal_homeostasis0.90818792
78MP0003806_abnormal_nucleotide_metabolis0.90268224
79MP0002572_abnormal_emotion/affect_behav0.89357548
80MP0002693_abnormal_pancreas_physiology0.89124110
81MP0004019_abnormal_vitamin_homeostasis0.88891346
82MP0004215_abnormal_myocardial_fiber0.88302944
83MP0001324_abnormal_eye_pigmentation0.87706948
84MP0001502_abnormal_circadian_rhythm0.84663865
85MP0002229_neurodegeneration0.84530975
86MP0000538_abnormal_urinary_bladder0.84290755
87MP0003698_abnormal_male_reproductive0.83850744
88MP0003172_abnormal_lysosome_physiology0.83162013
89MP0002064_seizures0.82144653
90MP0005410_abnormal_fertilization0.81867975
91MP0002139_abnormal_hepatobiliary_system0.79495588
92MP0001293_anophthalmia0.79432316
93MP0002138_abnormal_hepatobiliary_system0.79431774
94MP0002653_abnormal_ependyma_morphology0.78672562
95MP0001929_abnormal_gametogenesis0.77375635
96MP0001944_abnormal_pancreas_morphology0.76379124
97MP0004147_increased_porphyrin_level0.76249135
98MP0002067_abnormal_sensory_capabilities0.76214094
99MP0000230_abnormal_systemic_arterial0.76141150
100MP0005395_other_phenotype0.75229436

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.30548177
2Pancreatic fibrosis (HP:0100732)3.91936704
3Congenital stationary night blindness (HP:0007642)3.85211183
4True hermaphroditism (HP:0010459)3.68246519
5Abnormality of the renal cortex (HP:0011035)3.65543600
6Nephronophthisis (HP:0000090)3.54060256
7Attenuation of retinal blood vessels (HP:0007843)3.50959831
8Abnormality of midbrain morphology (HP:0002418)3.45332709
9Molar tooth sign on MRI (HP:0002419)3.45332709
10Tubular atrophy (HP:0000092)3.32835716
11Hypothermia (HP:0002045)3.31511340
12Chronic hepatic failure (HP:0100626)3.27733641
13Medial flaring of the eyebrow (HP:0010747)3.21294772
14Abnormality of the renal medulla (HP:0100957)3.15023597
15Abnormal rod and cone electroretinograms (HP:0008323)2.90279517
16Decreased central vision (HP:0007663)2.88425413
17Polydipsia (HP:0001959)2.73192040
18Abnormal drinking behavior (HP:0030082)2.73192040
19Pendular nystagmus (HP:0012043)2.71687662
20Delayed CNS myelination (HP:0002188)2.71121866
21Albinism (HP:0001022)2.70068890
22Abolished electroretinogram (ERG) (HP:0000550)2.66187407
23Renal cortical cysts (HP:0000803)2.59794820
24Type II lissencephaly (HP:0007260)2.55424322
25Gait imbalance (HP:0002141)2.54023061
26Congenital primary aphakia (HP:0007707)2.53236142
27Abnormal biliary tract physiology (HP:0012439)2.49100336
28Bile duct proliferation (HP:0001408)2.49100336
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48727810
30Acute necrotizing encephalopathy (HP:0006965)2.47096775
31Progressive macrocephaly (HP:0004481)2.42441319
32Mitochondrial inheritance (HP:0001427)2.40255393
33Increased CSF lactate (HP:0002490)2.38964542
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35189755
35Cystic liver disease (HP:0006706)2.26949409
36Acute encephalopathy (HP:0006846)2.25590736
37Nephrogenic diabetes insipidus (HP:0009806)2.22445545
38Hyperglycinemia (HP:0002154)2.22112187
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.20985033
40Sclerocornea (HP:0000647)2.20881007
41Postaxial foot polydactyly (HP:0001830)2.19840889
42Genital tract atresia (HP:0001827)2.18097306
43Bony spicule pigmentary retinopathy (HP:0007737)2.15885844
44Congenital hepatic fibrosis (HP:0002612)2.14673327
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.11731625
463-Methylglutaconic aciduria (HP:0003535)2.11721754
47Hyperventilation (HP:0002883)2.11590069
48Optic disc pallor (HP:0000543)2.10458997
49Retinitis pigmentosa (HP:0000510)2.09459950
50Hepatocellular necrosis (HP:0001404)2.09153486
51Hepatic necrosis (HP:0002605)2.08945716
52Polyuria (HP:0000103)2.08876042
53Lipid accumulation in hepatocytes (HP:0006561)2.07285490
54Abnormal mitochondria in muscle tissue (HP:0008316)2.06735590
55Neoplasm of the adrenal cortex (HP:0100641)2.06697958
56Asplenia (HP:0001746)2.06297286
57Gaze-evoked nystagmus (HP:0000640)2.04390706
58Vaginal atresia (HP:0000148)2.03225908
59Tubulointerstitial nephritis (HP:0001970)2.02079586
60Supernumerary spleens (HP:0009799)2.00720578
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00294023
62Colon cancer (HP:0003003)1.99499167
63Glycosuria (HP:0003076)1.99352811
64Abnormality of urine glucose concentration (HP:0011016)1.99352811
65Increased corneal curvature (HP:0100692)1.98912456
66Keratoconus (HP:0000563)1.98912456
67Decreased circulating renin level (HP:0003351)1.98677686
68Volvulus (HP:0002580)1.98454617
69Optic nerve hypoplasia (HP:0000609)1.98401399
70Male pseudohermaphroditism (HP:0000037)1.96974776
71Abnormality of the labia minora (HP:0012880)1.96364674
72Intestinal atresia (HP:0011100)1.92773355
73Ketosis (HP:0001946)1.92211910
74Increased hepatocellular lipid droplets (HP:0006565)1.91458495
75Furrowed tongue (HP:0000221)1.89740347
76Anencephaly (HP:0002323)1.88515217
77Large for gestational age (HP:0001520)1.87397622
78Rib fusion (HP:0000902)1.87343517
79Cerebellar dysplasia (HP:0007033)1.84057031
80Inability to walk (HP:0002540)1.83497033
81Poor coordination (HP:0002370)1.79032782
82Dynein arm defect of respiratory motile cilia (HP:0012255)1.77876890
83Absent/shortened dynein arms (HP:0200106)1.77876890
84Tubulointerstitial abnormality (HP:0001969)1.77233530
85Hypomagnesemia (HP:0002917)1.77036089
86Hemiparesis (HP:0001269)1.76153346
87Lissencephaly (HP:0001339)1.75822978
88Postaxial hand polydactyly (HP:0001162)1.72640870
89Hyperlipoproteinemia (HP:0010980)1.69920897
90Abnormality of macular pigmentation (HP:0008002)1.69223418
91Thyroid-stimulating hormone excess (HP:0002925)1.68581195
92Abnormal urine output (HP:0012590)1.67973327
93Abnormal respiratory epithelium morphology (HP:0012253)1.67527423
94Abnormal respiratory motile cilium morphology (HP:0005938)1.67527423
95Abnormality of vitamin B metabolism (HP:0004340)1.67161370
96Hyperglycinuria (HP:0003108)1.66969259
97Generalized aminoaciduria (HP:0002909)1.66422666
98Congenital sensorineural hearing impairment (HP:0008527)1.65077997
99Progressive inability to walk (HP:0002505)1.65014132
100Growth hormone deficiency (HP:0000824)1.64973706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.35262269
2WNK33.60013021
3ADRBK22.91528473
4GRK12.91138221
5ZAK2.88208681
6NUAK12.75943246
7MAP4K22.65486252
8BMPR1B2.26110165
9TLK12.25951774
10PINK12.00125087
11WNK41.99420571
12TAOK31.88700803
13CCNB11.85471665
14FGFR21.63282460
15ACVR1B1.63017393
16MAPK131.57116387
17TXK1.52193978
18VRK21.44420871
19STK391.35485529
20EPHA31.34319285
21TNIK1.33396202
22MST41.32353368
23STK161.32058493
24PAK31.29726098
25MAP3K41.29486124
26NTRK31.22600627
27OXSR11.19310568
28INSRR1.18856363
29VRK11.16485465
30EIF2AK31.11538618
31PLK21.10204373
32MAP2K61.06718997
33CASK1.05031769
34PHKG21.01846554
35PHKG11.01846554
36MKNK21.00710227
37PLK31.00705863
38ADRBK10.93693810
39TRIM280.93180613
40PRKCE0.92995099
41PLK40.92972010
42PRKCG0.91453126
43CDC70.90828802
44TAF10.82211076
45DYRK20.79205730
46NLK0.77132333
47SIK20.75506351
48IRAK10.75104824
49TNK20.73487903
50PRKCQ0.72975789
51TEC0.72592498
52STK30.71910018
53CSNK1G10.69283749
54CSNK1G20.68975279
55BRSK20.68123739
56FER0.67287743
57CSNK1G30.65591925
58IKBKB0.63945894
59RPS6KA50.62694760
60MUSK0.61807203
61CAMK2D0.58507757
62PRKCI0.57102735
63FGFR30.56234785
64MAP2K70.54730555
65PTK2B0.54727326
66PDK20.54515991
67STK38L0.54338684
68STK110.53965357
69CSNK1A1L0.53613839
70DAPK20.53023079
71TIE10.52745893
72CLK10.51596516
73CDK190.49938022
74EIF2AK20.48431697
75NME10.47612859
76CDK30.47227199
77AKT30.46545126
78CAMKK20.46264790
79PRKACA0.44850395
80PIK3CA0.44365077
81PRKAA20.44118461
82MAPKAPK30.43396964
83GRK50.43233519
84KIT0.42730880
85CAMK2A0.41727206
86ATM0.40916650
87PLK10.40304986
88ERBB20.38959584
89PKN10.38287276
90PASK0.38147482
91CSNK1A10.37219622
92BCR0.36444142
93ITK0.35686908
94MARK30.35361605
95BCKDK0.34816673
96MARK10.32270950
97ABL10.31416339
98SYK0.31211578
99CSNK1D0.31084403
100TGFBR10.30891811

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.08084321
2Phototransduction_Homo sapiens_hsa047442.74451441
3Linoleic acid metabolism_Homo sapiens_hsa005912.62473996
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.61319180
5Selenocompound metabolism_Homo sapiens_hsa004502.57909042
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54374711
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53037024
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48753489
9Peroxisome_Homo sapiens_hsa041462.04730230
10Oxidative phosphorylation_Homo sapiens_hsa001902.03746412
11One carbon pool by folate_Homo sapiens_hsa006702.02770125
12RNA polymerase_Homo sapiens_hsa030201.97288972
13Nitrogen metabolism_Homo sapiens_hsa009101.92281678
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90856567
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.88396615
16Protein export_Homo sapiens_hsa030601.84809714
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84043269
18Caffeine metabolism_Homo sapiens_hsa002321.80695344
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76171817
20Ether lipid metabolism_Homo sapiens_hsa005651.74027518
21Tryptophan metabolism_Homo sapiens_hsa003801.66475038
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60663995
23Homologous recombination_Homo sapiens_hsa034401.53609423
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53443444
25Parkinsons disease_Homo sapiens_hsa050121.51460613
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51156312
27Propanoate metabolism_Homo sapiens_hsa006401.45683014
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.45067740
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43358738
30Fanconi anemia pathway_Homo sapiens_hsa034601.42913843
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41682002
32Basal transcription factors_Homo sapiens_hsa030221.39395169
33Retinol metabolism_Homo sapiens_hsa008301.36276624
34Nicotine addiction_Homo sapiens_hsa050331.34042878
35RNA degradation_Homo sapiens_hsa030181.25388441
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23984824
37Chemical carcinogenesis_Homo sapiens_hsa052041.18982084
38ABC transporters_Homo sapiens_hsa020101.18813004
39Arachidonic acid metabolism_Homo sapiens_hsa005901.16579775
40Fat digestion and absorption_Homo sapiens_hsa049751.13508426
41Sulfur metabolism_Homo sapiens_hsa009201.05039340
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01482704
43Huntingtons disease_Homo sapiens_hsa050160.99365669
44Olfactory transduction_Homo sapiens_hsa047400.98257351
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94717723
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93264271
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91533104
48Purine metabolism_Homo sapiens_hsa002300.90777217
49Type I diabetes mellitus_Homo sapiens_hsa049400.89349771
50Alzheimers disease_Homo sapiens_hsa050100.88586674
51Taste transduction_Homo sapiens_hsa047420.88483661
52Fatty acid degradation_Homo sapiens_hsa000710.88442299
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87217834
54beta-Alanine metabolism_Homo sapiens_hsa004100.86836116
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86784344
56Fatty acid elongation_Homo sapiens_hsa000620.85116695
57Proteasome_Homo sapiens_hsa030500.85039448
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84483404
59Fatty acid metabolism_Homo sapiens_hsa012120.83638634
60Insulin secretion_Homo sapiens_hsa049110.81494507
61Cardiac muscle contraction_Homo sapiens_hsa042600.81286754
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80850717
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78275453
64Metabolic pathways_Homo sapiens_hsa011000.77537456
65Glycerolipid metabolism_Homo sapiens_hsa005610.77533340
66Regulation of autophagy_Homo sapiens_hsa041400.76600315
67Folate biosynthesis_Homo sapiens_hsa007900.75502118
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.74519313
69Morphine addiction_Homo sapiens_hsa050320.64268294
70Mineral absorption_Homo sapiens_hsa049780.62793957
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.62423575
72Primary immunodeficiency_Homo sapiens_hsa053400.60449244
73Serotonergic synapse_Homo sapiens_hsa047260.59901976
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58261676
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58188654
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56956129
77GABAergic synapse_Homo sapiens_hsa047270.54140452
78Histidine metabolism_Homo sapiens_hsa003400.54010390
79Sulfur relay system_Homo sapiens_hsa041220.52827502
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52798369
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52143550
82Non-homologous end-joining_Homo sapiens_hsa034500.51813513
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.51430084
84Glutathione metabolism_Homo sapiens_hsa004800.49589715
85Circadian entrainment_Homo sapiens_hsa047130.48045620
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47893256
87Glutamatergic synapse_Homo sapiens_hsa047240.46232276
88Circadian rhythm_Homo sapiens_hsa047100.46023027
89Collecting duct acid secretion_Homo sapiens_hsa049660.45782300
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44056598
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43348440
92Ovarian steroidogenesis_Homo sapiens_hsa049130.43143055
93Pyrimidine metabolism_Homo sapiens_hsa002400.42768263
94Steroid biosynthesis_Homo sapiens_hsa001000.41986112
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.38598655
96Complement and coagulation cascades_Homo sapiens_hsa046100.38194040
97Lysine degradation_Homo sapiens_hsa003100.38108735
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36110169
99Ribosome_Homo sapiens_hsa030100.35725885
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.33992128

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