ZNF552

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)4.81450052
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.50509522
3regulation of translation, ncRNA-mediated (GO:0045974)4.50509522
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.50509522
5L-fucose catabolic process (GO:0042355)4.00374086
6fucose catabolic process (GO:0019317)4.00374086
7L-fucose metabolic process (GO:0042354)4.00374086
8histone H3-K9 methylation (GO:0051567)3.94265517
9protein K11-linked deubiquitination (GO:0035871)3.75140172
10positive regulation by host of viral transcription (GO:0043923)3.37106286
11histone H3-K9 modification (GO:0061647)3.33920920
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.32873079
13meiotic chromosome segregation (GO:0045132)3.24786947
14establishment of protein localization to Golgi (GO:0072600)3.23335455
15behavioral response to nicotine (GO:0035095)3.17541428
16preassembly of GPI anchor in ER membrane (GO:0016254)3.14532753
17replication fork processing (GO:0031297)3.13632476
18neural tube formation (GO:0001841)3.08387516
19DNA double-strand break processing (GO:0000729)3.05177784
20reciprocal meiotic recombination (GO:0007131)2.92382240
21reciprocal DNA recombination (GO:0035825)2.92382240
22prostate gland growth (GO:0060736)2.89081787
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88851306
24intestinal epithelial cell development (GO:0060576)2.86723713
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86225883
26tryptophan catabolic process (GO:0006569)2.85160835
27indole-containing compound catabolic process (GO:0042436)2.85160835
28indolalkylamine catabolic process (GO:0046218)2.85160835
29DNA methylation involved in gamete generation (GO:0043046)2.84902355
30somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82791736
31somatic hypermutation of immunoglobulin genes (GO:0016446)2.82791736
32GPI anchor metabolic process (GO:0006505)2.81166867
33tryptophan metabolic process (GO:0006568)2.77851053
34regulation of posttranscriptional gene silencing (GO:0060147)2.76226404
35regulation of gene silencing by miRNA (GO:0060964)2.76226404
36regulation of gene silencing by RNA (GO:0060966)2.76226404
37regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74284546
38indolalkylamine metabolic process (GO:0006586)2.74122675
39protein targeting to Golgi (GO:0000042)2.73642514
40regulation of memory T cell differentiation (GO:0043380)2.73580463
41pantothenate metabolic process (GO:0015939)2.73251206
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72041492
43negative regulation of telomere maintenance (GO:0032205)2.71797433
44histone H3-K4 trimethylation (GO:0080182)2.71761884
45iron ion import (GO:0097286)2.70574512
46histone H3-K36 demethylation (GO:0070544)2.69007560
47regulation of mesoderm development (GO:2000380)2.68528839
48synapsis (GO:0007129)2.68430964
49positive regulation of mRNA catabolic process (GO:0061014)2.66370061
50cilium or flagellum-dependent cell motility (GO:0001539)2.66329414
51peptidyl-lysine trimethylation (GO:0018023)2.63960650
52pseudouridine synthesis (GO:0001522)2.61488349
53GPI anchor biosynthetic process (GO:0006506)2.61380166
54regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.60523432
55positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.60523432
56double-strand break repair via homologous recombination (GO:0000724)2.60292267
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59472011
58isotype switching (GO:0045190)2.59472011
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59472011
60peptidyl-lysine methylation (GO:0018022)2.59044265
61mitochondrial RNA metabolic process (GO:0000959)2.59009089
62kynurenine metabolic process (GO:0070189)2.58961265
63histone H3-K4 methylation (GO:0051568)2.58271434
64gene silencing by RNA (GO:0031047)2.57595110
65recombinational repair (GO:0000725)2.57568235
66histone mRNA catabolic process (GO:0071044)2.55403487
67regulation of establishment of cell polarity (GO:2000114)2.54534404
68pyrimidine-containing compound transmembrane transport (GO:0072531)2.53369441
69resolution of meiotic recombination intermediates (GO:0000712)2.51262962
70histone lysine methylation (GO:0034968)2.50708443
71monoubiquitinated protein deubiquitination (GO:0035520)2.48791321
72regulation of telomere maintenance (GO:0032204)2.47671655
73cornea development in camera-type eye (GO:0061303)2.47414245
74piRNA metabolic process (GO:0034587)2.47409219
75retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47134480
76regulation of clathrin-mediated endocytosis (GO:2000369)2.45847867
77regulation of establishment or maintenance of cell polarity (GO:0032878)2.45618207
78DNA deamination (GO:0045006)2.44289516
79keratinocyte development (GO:0003334)2.43132006
80regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.42781127
81positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.42781127
82epithelial cilium movement (GO:0003351)2.41494386
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41491860
84purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.41147688
853-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.41147688
86base-excision repair, AP site formation (GO:0006285)2.41081826
87S-adenosylmethionine metabolic process (GO:0046500)2.40545599
88rRNA catabolic process (GO:0016075)2.40399087
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.40245274
90protein localization to Golgi apparatus (GO:0034067)2.39926846
91regulation of mRNA catabolic process (GO:0061013)2.39616853
92axoneme assembly (GO:0035082)2.38362611
93multicellular organism reproduction (GO:0032504)2.38322791
94genitalia morphogenesis (GO:0035112)2.37101308
95detection of light stimulus involved in sensory perception (GO:0050962)2.36889235
96detection of light stimulus involved in visual perception (GO:0050908)2.36889235
97male meiosis (GO:0007140)2.36435920
98protein K48-linked deubiquitination (GO:0071108)2.36034340
99positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.35537930
100organelle membrane fusion (GO:0090174)2.35462291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.41911154
2* ESR1_20079471_ChIP-ChIP_T-47D_Human4.08110995
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.43443721
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.07668400
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75662528
6VDR_22108803_ChIP-Seq_LS180_Human2.55329064
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42129671
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37552375
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.35965253
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33544489
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.33203344
12ER_23166858_ChIP-Seq_MCF-7_Human2.21199135
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06387758
14* VDR_23849224_ChIP-Seq_CD4+_Human2.03826670
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.93866352
16ELK1_19687146_ChIP-ChIP_HELA_Human1.93072418
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90969348
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.90371830
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.84208542
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82985593
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82964314
22IGF1R_20145208_ChIP-Seq_DFB_Human1.79421401
23EWS_26573619_Chip-Seq_HEK293_Human1.78681420
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.78648323
25* KDM5A_27292631_Chip-Seq_BREAST_Human1.77148228
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74823742
27HOXB7_26014856_ChIP-Seq_BT474_Human1.73500530
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71403848
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66536219
30AHR_22903824_ChIP-Seq_MCF-7_Human1.56353099
31ELF5_23300383_ChIP-Seq_T47D_Human1.55126485
32BCAT_22108803_ChIP-Seq_LS180_Human1.52779707
33FUS_26573619_Chip-Seq_HEK293_Human1.48902972
34TP53_22573176_ChIP-Seq_HFKS_Human1.48594813
35* ETS1_20019798_ChIP-Seq_JURKAT_Human1.44778995
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42767021
37IRF1_19129219_ChIP-ChIP_H3396_Human1.42365723
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39894337
39TAF15_26573619_Chip-Seq_HEK293_Human1.39873507
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.37370909
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35295319
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33536691
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33129099
44CBP_20019798_ChIP-Seq_JUKART_Human1.33129099
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33061504
46GBX2_23144817_ChIP-Seq_PC3_Human1.32910695
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32466866
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.32212949
49AR_21572438_ChIP-Seq_LNCaP_Human1.27790657
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27778042
51P300_19829295_ChIP-Seq_ESCs_Human1.26898765
52FOXP3_21729870_ChIP-Seq_TREG_Human1.25536338
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24960906
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23406130
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23324150
56STAT3_23295773_ChIP-Seq_U87_Human1.22303551
57AR_20517297_ChIP-Seq_VCAP_Human1.19989101
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19593517
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19593517
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16647496
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.16503559
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.16231344
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16231344
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15472143
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13049544
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11403057
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.11084825
68TCF4_23295773_ChIP-Seq_U87_Human1.10263823
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09466851
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09306915
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09061164
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08784781
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08692547
74TCF4_22108803_ChIP-Seq_LS180_Human1.06827190
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06468585
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05799420
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05658029
78* GATA3_26560356_Chip-Seq_TH2_Human1.05545310
79GATA4_25053715_ChIP-Seq_YYC3_Human1.05414763
80FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02035367
81RUNX2_22187159_ChIP-Seq_PCA_Human1.01360034
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.01325507
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01141328
84FOXA1_25552417_ChIP-Seq_VCAP_Human1.00245035
85NANOG_19829295_ChIP-Seq_ESCs_Human1.00032604
86SOX2_19829295_ChIP-Seq_ESCs_Human1.00032604
87CDX2_22108803_ChIP-Seq_LS180_Human0.97883202
88GABP_19822575_ChIP-Seq_HepG2_Human0.97061511
89* MYC_18940864_ChIP-ChIP_HL60_Human0.95729964
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95168622
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93966809
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.93349883
93* GATA3_24758297_ChIP-Seq_MCF-7_Human0.93297520
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93034171
95* ERA_21632823_ChIP-Seq_H3396_Human0.92052739
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91140402
97NCOR_22424771_ChIP-Seq_293T_Human0.90894894
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90823411
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90753624
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89180268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.37761956
2MP0000427_abnormal_hair_cycle3.04894855
3MP0008877_abnormal_DNA_methylation2.95238938
4MP0004264_abnormal_extraembryonic_tissu2.61499833
5MP0008057_abnormal_DNA_replication2.59275309
6MP0003195_calcinosis2.57551574
7MP0003890_abnormal_embryonic-extraembry2.55787990
8MP0000569_abnormal_digit_pigmentation2.34848839
9MP0001919_abnormal_reproductive_system2.27002758
10MP0004381_abnormal_hair_follicle2.18065434
11MP0000383_abnormal_hair_follicle2.16362816
12MP0003136_yellow_coat_color2.13691380
13MP0001986_abnormal_taste_sensitivity2.13308746
14MP0008995_early_reproductive_senescence2.09642526
15MP0004147_increased_porphyrin_level2.08423735
16MP0008058_abnormal_DNA_repair2.02501833
17MP0003718_maternal_effect1.98162221
18MP0002098_abnormal_vibrissa_morphology1.94660931
19MP0003646_muscle_fatigue1.89268027
20MP0005075_abnormal_melanosome_morpholog1.84840195
21MP0004133_heterotaxia1.78430414
22MP0008872_abnormal_physiological_respon1.77250778
23MP0004145_abnormal_muscle_electrophysio1.75696950
24MP0002277_abnormal_respiratory_mucosa1.74833840
25MP0004043_abnormal_pH_regulation1.69379165
26MP0010678_abnormal_skin_adnexa1.68838869
27MP0005083_abnormal_biliary_tract1.57115060
28MP0001873_stomach_inflammation1.56468335
29MP0005310_abnormal_salivary_gland1.48974749
30MP0005408_hypopigmentation1.48667875
31MP0008875_abnormal_xenobiotic_pharmacok1.48191709
32MP0005389_reproductive_system_phenotype1.47918401
33MP0005174_abnormal_tail_pigmentation1.44343720
34MP0002160_abnormal_reproductive_system1.42046031
35MP0005551_abnormal_eye_electrophysiolog1.38805436
36MP0005379_endocrine/exocrine_gland_phen1.32899947
37MP0003724_increased_susceptibility_to1.22659101
38MP0005395_other_phenotype1.21987589
39MP0000470_abnormal_stomach_morphology1.21384807
40MP0005085_abnormal_gallbladder_physiolo1.21083339
41MP0006035_abnormal_mitochondrial_morpho1.20970951
42MP0000372_irregular_coat_pigmentation1.20400871
43MP0003787_abnormal_imprinting1.20111340
44MP0002653_abnormal_ependyma_morphology1.19034769
45MP0000647_abnormal_sebaceous_gland1.15128894
46MP0005248_abnormal_Harderian_gland1.13960809
47MP0005645_abnormal_hypothalamus_physiol1.12615113
48MP0000371_diluted_coat_color1.11830739
49MP0005367_renal/urinary_system_phenotyp1.07656472
50MP0000516_abnormal_urinary_system1.07656472
51MP0003943_abnormal_hepatobiliary_system1.07277648
52MP0004883_abnormal_blood_vessel1.06131810
53MP0001929_abnormal_gametogenesis1.05414086
54MP0001764_abnormal_homeostasis1.00070261
55MP0002876_abnormal_thyroid_physiology0.99923273
56MP0003119_abnormal_digestive_system0.99047615
57MP0002210_abnormal_sex_determination0.98654840
58MP0003693_abnormal_embryo_hatching0.98003720
59MP0002009_preneoplasia0.93723502
60MP0005646_abnormal_pituitary_gland0.93035742
61MP0003183_abnormal_peptide_metabolism0.92996418
62MP0001968_abnormal_touch/_nociception0.91163695
63MP0001346_abnormal_lacrimal_gland0.89708527
64MP0003786_premature_aging0.89703805
65MP0000015_abnormal_ear_pigmentation0.89562318
66MP0002168_other_aberrant_phenotype0.89510624
67MP0002751_abnormal_autonomic_nervous0.89077783
68MP0001664_abnormal_digestion0.88998178
69MP0005084_abnormal_gallbladder_morpholo0.88729272
70MP0003045_fibrosis0.88450950
71MP0001145_abnormal_male_reproductive0.87940088
72MP0002396_abnormal_hematopoietic_system0.87844195
73MP0000653_abnormal_sex_gland0.87375545
74MP0003936_abnormal_reproductive_system0.86248506
75MP0010094_abnormal_chromosome_stability0.85883378
76MP0002928_abnormal_bile_duct0.85698155
77MP0000631_abnormal_neuroendocrine_gland0.82642214
78MP0002282_abnormal_trachea_morphology0.82500144
79MP0003077_abnormal_cell_cycle0.82300643
80MP0003698_abnormal_male_reproductive0.82282015
81MP0001485_abnormal_pinna_reflex0.81088888
82MP0003221_abnormal_cardiomyocyte_apopto0.79931678
83MP0002138_abnormal_hepatobiliary_system0.79076950
84MP0004233_abnormal_muscle_weight0.77295782
85MP0002088_abnormal_embryonic_growth/wei0.76686365
86MP0001765_abnormal_ion_homeostasis0.76428771
87MP0003567_abnormal_fetal_cardiomyocyte0.76125657
88MP0010329_abnormal_lipoprotein_level0.75497315
89MP0001119_abnormal_female_reproductive0.74556389
90MP0005253_abnormal_eye_physiology0.74114262
91MP0003937_abnormal_limbs/digits/tail_de0.73135347
92MP0002132_abnormal_respiratory_system0.70444277
93MP0003984_embryonic_growth_retardation0.69867268
94MP0005380_embryogenesis_phenotype0.69217828
95MP0001672_abnormal_embryogenesis/_devel0.69217828
96MP0001666_abnormal_nutrient_absorption0.66515069
97MP0001324_abnormal_eye_pigmentation0.66345450
98MP0003252_abnormal_bile_duct0.64857020
99MP0005636_abnormal_mineral_homeostasis0.64332071
100MP0002909_abnormal_adrenal_gland0.62617531

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)3.89080067
2Pancreatic cysts (HP:0001737)3.43182792
3Stomach cancer (HP:0012126)3.26046147
4Abnormality of the renal cortex (HP:0011035)3.11175750
5Pancreatic fibrosis (HP:0100732)2.92436459
6Abnormality of midbrain morphology (HP:0002418)2.92128387
7Molar tooth sign on MRI (HP:0002419)2.92128387
8True hermaphroditism (HP:0010459)2.90271907
9Genetic anticipation (HP:0003743)2.82944069
10Congenital stationary night blindness (HP:0007642)2.76297675
11Chronic hepatic failure (HP:0100626)2.75820560
12Abnormality of alanine metabolism (HP:0010916)2.67959967
13Hyperalaninemia (HP:0003348)2.67959967
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67959967
15Attenuation of retinal blood vessels (HP:0007843)2.64679610
16Amelogenesis imperfecta (HP:0000705)2.62157562
17Colon cancer (HP:0003003)2.60450216
18Abnormality of the renal medulla (HP:0100957)2.56470699
19Nephronophthisis (HP:0000090)2.55517782
20Ependymoma (HP:0002888)2.55296068
21Tubular atrophy (HP:0000092)2.52647539
22Sparse lateral eyebrow (HP:0005338)2.41853643
23Type 2 muscle fiber atrophy (HP:0003554)2.28941296
24Tubulointerstitial nephritis (HP:0001970)2.28810338
25Glioma (HP:0009733)2.27629886
26Progressive inability to walk (HP:0002505)2.27585329
27Decreased circulating renin level (HP:0003351)2.25709572
28Abnormality of chromosome stability (HP:0003220)2.24771823
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.24286038
30Gaze-evoked nystagmus (HP:0000640)2.22684245
31Hyperglycinuria (HP:0003108)2.21847014
32Type II lissencephaly (HP:0007260)2.19945127
33Abnormal biliary tract physiology (HP:0012439)2.19797358
34Bile duct proliferation (HP:0001408)2.19797358
35Pendular nystagmus (HP:0012043)2.14474410
36Furrowed tongue (HP:0000221)2.13346594
37Lissencephaly (HP:0001339)2.10797631
38Abnormality of the ileum (HP:0001549)2.07377519
39Abnormality of the preputium (HP:0100587)2.06857058
40Progressive cerebellar ataxia (HP:0002073)2.05042588
41Clubbing of toes (HP:0100760)2.03697716
42Depressed nasal tip (HP:0000437)2.03270205
43Cystic liver disease (HP:0006706)2.02490835
44Abnormal rod and cone electroretinograms (HP:0008323)2.01019944
45Volvulus (HP:0002580)1.98919892
46Abnormality of the astrocytes (HP:0100707)1.98462487
47Astrocytoma (HP:0009592)1.98462487
48Abnormality of homocysteine metabolism (HP:0010919)1.96312592
49Homocystinuria (HP:0002156)1.96312592
50Meckel diverticulum (HP:0002245)1.95568113
51Renal cortical cysts (HP:0000803)1.94311151
52Abnormality of macular pigmentation (HP:0008002)1.93829855
53Birth length less than 3rd percentile (HP:0003561)1.93526230
54Large for gestational age (HP:0001520)1.93493814
55Neoplasm of the adrenal cortex (HP:0100641)1.87599930
56Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87542569
57Stomatitis (HP:0010280)1.87293517
58Cerebellar dysplasia (HP:0007033)1.86194817
59Methylmalonic acidemia (HP:0002912)1.86100073
60Fair hair (HP:0002286)1.84494700
61Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83301372
62Abnormality of the nasal septum (HP:0000419)1.82311237
63Patellar aplasia (HP:0006443)1.81751060
64Sloping forehead (HP:0000340)1.81565575
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.80004393
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.79555707
67Neoplasm of the adrenal gland (HP:0100631)1.79146993
68Hypoplastic ischia (HP:0003175)1.78847067
69Inability to walk (HP:0002540)1.77541601
70Severe visual impairment (HP:0001141)1.77168443
71Medial flaring of the eyebrow (HP:0010747)1.75759113
72Abolished electroretinogram (ERG) (HP:0000550)1.73636114
73Widely spaced teeth (HP:0000687)1.73184866
74Abnormality of DNA repair (HP:0003254)1.72797472
75Abnormality of serine family amino acid metabolism (HP:0010894)1.72782058
76Abnormality of glycine metabolism (HP:0010895)1.72782058
77Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72697913
78Abnormality of the pons (HP:0007361)1.72197965
79Lip pit (HP:0100267)1.71899448
80Neonatal respiratory distress (HP:0002643)1.71693961
81Ectopic kidney (HP:0000086)1.70326342
82Anencephaly (HP:0002323)1.70319462
83Abnormality of the axillary hair (HP:0100134)1.70194942
84Abnormality of secondary sexual hair (HP:0009888)1.70194942
85Absent thumb (HP:0009777)1.69464972
86Breast carcinoma (HP:0003002)1.67029095
87Generalized hypopigmentation of hair (HP:0011358)1.66521686
88Disproportionate short-trunk short stature (HP:0003521)1.65161159
89Protruding tongue (HP:0010808)1.64986185
90Macular degeneration (HP:0000608)1.64798828
91Abnormality of the parathyroid morphology (HP:0011766)1.64730757
92Anal stenosis (HP:0002025)1.63548834
93Abnormality of the pubic bones (HP:0003172)1.63315117
94Hyperventilation (HP:0002883)1.63016575
95Oligodactyly (hands) (HP:0001180)1.61257629
96Methylmalonic aciduria (HP:0012120)1.60661430
97Aplasia/Hypoplasia of the patella (HP:0006498)1.60165684
98Abnormal drinking behavior (HP:0030082)1.60060272
99Polydipsia (HP:0001959)1.60060272
100Astigmatism (HP:0000483)1.59109310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.69326423
2MUSK4.33709609
3BMPR1B3.50479618
4MAP4K23.36601219
5ACVR1B3.06681203
6WNK32.45671306
7ZAK2.32847135
8AKT32.09326670
9ADRBK22.04856892
10WNK41.96438129
11IRAK11.95393975
12TNK21.92513350
13GRK11.80456588
14TRIM281.69901781
15MST41.68876340
16BRSK21.62592108
17NME11.56479968
18NUAK11.53646243
19NLK1.50761456
20OXSR11.47655831
21TAOK31.46664396
22INSRR1.42451583
23IRAK41.42089630
24GRK61.34965814
25TGFBR11.34739225
26MAPKAPK31.33632665
27YES11.27726629
28TSSK61.21300087
29RPS6KB21.21140626
30STK391.16873044
31TRPM71.16637815
32CAMK1D1.10258995
33MAPK131.09564190
34FER1.09199396
35PNCK1.07696499
36MATK1.07255930
37BCR1.00314027
38EPHA20.99681607
39PBK0.93340497
40MAP3K40.89983461
41CHUK0.88323127
42LATS10.88291257
43SIK30.87553661
44PAK30.87271412
45CDK120.85709796
46MAP2K70.83438748
47STK38L0.80676774
48TEC0.79342238
49SGK20.79057211
50IRAK20.77321862
51TNIK0.73764572
52PIK3CA0.73584771
53SRPK10.73067167
54ERBB20.73009924
55MAP2K60.72198731
56DYRK20.71609204
57MKNK20.71023432
58BLK0.70995962
59PRKCI0.70647278
60EIF2AK30.69080193
61WEE10.67456215
62ADRBK10.67064463
63PRKAA20.63965762
64PKN20.58745609
65MAP4K10.58387987
66DAPK20.58004433
67DYRK30.57348668
68IKBKE0.57310664
69ATR0.56516404
70MAPK150.55522421
71ZAP700.54645007
72BRD40.54479783
73IKBKB0.52121782
74TLK10.51472715
75CSNK1G10.51048434
76NEK60.50758270
77MARK30.50023358
78MELK0.49254092
79VRK10.47343282
80PINK10.46384653
81FGFR20.46267164
82CSNK1A1L0.43964213
83RPS6KB10.43006030
84PRKCZ0.42788438
85ATM0.40754088
86PLK30.39359289
87CAMKK20.39003551
88CAMK1G0.38935344
89PIM10.37599416
90PRKCE0.34599737
91CDK70.34228594
92BTK0.34086187
93LCK0.33266267
94PRKAA10.32222982
95RIPK40.31872466
96SGK4940.30085678
97SGK2230.30085678
98MAP2K40.29771659
99SIK20.29722181
100PLK10.27915392

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.37657495
2Basal transcription factors_Homo sapiens_hsa030222.96566286
3Fanconi anemia pathway_Homo sapiens_hsa034602.80848842
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.74756069
5Nitrogen metabolism_Homo sapiens_hsa009102.67686341
6Caffeine metabolism_Homo sapiens_hsa002322.63573796
7Homologous recombination_Homo sapiens_hsa034402.49980043
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.42594999
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23308194
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11728293
11Non-homologous end-joining_Homo sapiens_hsa034502.10000884
12ABC transporters_Homo sapiens_hsa020102.06870603
13Linoleic acid metabolism_Homo sapiens_hsa005912.06583618
14RNA polymerase_Homo sapiens_hsa030201.93888962
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80526044
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80202368
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76249088
18Regulation of autophagy_Homo sapiens_hsa041401.68113607
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65021057
20RNA degradation_Homo sapiens_hsa030181.63398524
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61723584
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48506685
23Vitamin digestion and absorption_Homo sapiens_hsa049771.40480253
24Peroxisome_Homo sapiens_hsa041461.32822202
25Butanoate metabolism_Homo sapiens_hsa006501.31459570
26Lysine degradation_Homo sapiens_hsa003101.29841107
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.29255138
28Ether lipid metabolism_Homo sapiens_hsa005651.25077543
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24522351
30Steroid biosynthesis_Homo sapiens_hsa001001.21486745
31Phototransduction_Homo sapiens_hsa047441.18298382
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17020279
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15133248
34RNA transport_Homo sapiens_hsa030131.13369623
35Base excision repair_Homo sapiens_hsa034101.09797596
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08214242
37Primary immunodeficiency_Homo sapiens_hsa053401.06670550
38Protein export_Homo sapiens_hsa030601.06481371
39Tryptophan metabolism_Homo sapiens_hsa003801.03281178
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02225800
41mRNA surveillance pathway_Homo sapiens_hsa030150.99825649
42Sphingolipid metabolism_Homo sapiens_hsa006000.98690922
43Chemical carcinogenesis_Homo sapiens_hsa052040.97266216
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95933809
45One carbon pool by folate_Homo sapiens_hsa006700.93376225
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.92155526
47Fatty acid biosynthesis_Homo sapiens_hsa000610.91232206
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90842826
49Histidine metabolism_Homo sapiens_hsa003400.88548180
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.88072615
51Mineral absorption_Homo sapiens_hsa049780.83167018
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.78304349
53Sulfur metabolism_Homo sapiens_hsa009200.78101414
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76174913
55Taste transduction_Homo sapiens_hsa047420.75116136
56Ovarian steroidogenesis_Homo sapiens_hsa049130.72774115
57Legionellosis_Homo sapiens_hsa051340.71360278
58Propanoate metabolism_Homo sapiens_hsa006400.70203421
59Circadian rhythm_Homo sapiens_hsa047100.70040378
60Inositol phosphate metabolism_Homo sapiens_hsa005620.67887731
61Pyrimidine metabolism_Homo sapiens_hsa002400.67742366
62Olfactory transduction_Homo sapiens_hsa047400.67686941
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.67301009
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66434800
65Arachidonic acid metabolism_Homo sapiens_hsa005900.65310991
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.64254370
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63943807
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.62429245
69beta-Alanine metabolism_Homo sapiens_hsa004100.61117008
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58176218
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57852781
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56995528
73Purine metabolism_Homo sapiens_hsa002300.56665061
74Insulin resistance_Homo sapiens_hsa049310.54566938
75Nucleotide excision repair_Homo sapiens_hsa034200.52246081
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51811831
77TGF-beta signaling pathway_Homo sapiens_hsa043500.49442887
78Proteasome_Homo sapiens_hsa030500.48912909
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47645223
80Metabolic pathways_Homo sapiens_hsa011000.46719557
81FoxO signaling pathway_Homo sapiens_hsa040680.46605453
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45567315
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45483198
84Measles_Homo sapiens_hsa051620.44491579
85Oxidative phosphorylation_Homo sapiens_hsa001900.43061765
86Collecting duct acid secretion_Homo sapiens_hsa049660.42980052
87Spliceosome_Homo sapiens_hsa030400.40066145
88Retinol metabolism_Homo sapiens_hsa008300.39425261
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38956590
90T cell receptor signaling pathway_Homo sapiens_hsa046600.38812072
91p53 signaling pathway_Homo sapiens_hsa041150.38524752
92Huntingtons disease_Homo sapiens_hsa050160.38191365
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36468680
94Fat digestion and absorption_Homo sapiens_hsa049750.35039080
95Dorso-ventral axis formation_Homo sapiens_hsa043200.34854524
96Glycerolipid metabolism_Homo sapiens_hsa005610.34075686
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33292526
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33283455
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32514134
100Prostate cancer_Homo sapiens_hsa052150.32096186

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