ZNF536

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.25686619
2neuron cell-cell adhesion (GO:0007158)5.14193716
3presynaptic membrane assembly (GO:0097105)5.09268942
4postsynaptic membrane organization (GO:0001941)4.94749959
5presynaptic membrane organization (GO:0097090)4.76923610
6axonal fasciculation (GO:0007413)4.61611377
7vocalization behavior (GO:0071625)4.27701325
8nucleobase catabolic process (GO:0046113)4.19030663
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.16344322
10axon ensheathment in central nervous system (GO:0032291)4.11452211
11central nervous system myelination (GO:0022010)4.11452211
12neuron recognition (GO:0008038)4.05385602
13gamma-aminobutyric acid transport (GO:0015812)3.89151524
14negative regulation of neurotransmitter transport (GO:0051589)3.80597029
15protein localization to synapse (GO:0035418)3.77228634
16regulation of synaptic vesicle transport (GO:1902803)3.74242105
17limb bud formation (GO:0060174)3.72472916
18transmission of nerve impulse (GO:0019226)3.69523805
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.66779908
20regulation of synaptic vesicle exocytosis (GO:2000300)3.63989881
21establishment of mitochondrion localization (GO:0051654)3.61165329
22glutamate receptor signaling pathway (GO:0007215)3.55364856
23synaptic transmission, glutamatergic (GO:0035249)3.53547683
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50102664
25positive regulation of synapse assembly (GO:0051965)3.48830392
26dendritic spine morphogenesis (GO:0060997)3.45414800
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44704840
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43011102
29neurotransmitter-gated ion channel clustering (GO:0072578)3.41387494
30cell migration in hindbrain (GO:0021535)3.39422515
31behavioral response to nicotine (GO:0035095)3.38381099
32central nervous system projection neuron axonogenesis (GO:0021952)3.36294486
33synaptic vesicle exocytosis (GO:0016079)3.32702834
34regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32421372
35synaptic vesicle maturation (GO:0016188)3.30996166
36somite development (GO:0061053)3.29412693
37synapse assembly (GO:0007416)3.22910472
38forebrain neuron differentiation (GO:0021879)3.22888048
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22661890
40regulation of synapse structural plasticity (GO:0051823)3.20773429
41neuronal action potential propagation (GO:0019227)3.16681160
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.16517027
43substrate-independent telencephalic tangential migration (GO:0021826)3.16517027
44auditory behavior (GO:0031223)3.15299138
45regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14433905
46retinal ganglion cell axon guidance (GO:0031290)3.12721405
47exploration behavior (GO:0035640)3.09163481
48regulation of neurotransmitter uptake (GO:0051580)3.08523793
49regulation of respiratory system process (GO:0044065)3.07467055
50lateral sprouting from an epithelium (GO:0060601)3.07051488
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04277456
52dendrite morphogenesis (GO:0048813)3.01555826
53glutamate secretion (GO:0014047)3.00936479
54startle response (GO:0001964)2.98608458
55neuron-neuron synaptic transmission (GO:0007270)2.98164905
56regulation of glutamate receptor signaling pathway (GO:1900449)2.97733982
57skeletal muscle organ development (GO:0060538)2.95048273
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94186966
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93800724
60neurotransmitter secretion (GO:0007269)2.90788544
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88197844
62central nervous system neuron axonogenesis (GO:0021955)2.87959885
63nonmotile primary cilium assembly (GO:0035058)2.85536356
64neuromuscular synaptic transmission (GO:0007274)2.84359709
65regulation of respiratory gaseous exchange (GO:0043576)2.84146176
66neuronal ion channel clustering (GO:0045161)2.83023644
67neuronal stem cell maintenance (GO:0097150)2.82929452
68positive regulation of cell size (GO:0045793)2.82317884
69regulation of synapse assembly (GO:0051963)2.81645125
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79003221
71positive regulation of sodium ion transmembrane transport (GO:1902307)2.76986019
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76152139
73glycosphingolipid biosynthetic process (GO:0006688)2.75697834
74positive regulation of dendritic spine development (GO:0060999)2.75247321
75hippocampus development (GO:0021766)2.74424624
76synapse organization (GO:0050808)2.71244422
77membrane depolarization during action potential (GO:0086010)2.71124151
78spinal cord development (GO:0021510)2.70172097
79nerve growth factor signaling pathway (GO:0038180)2.69937511
80negative regulation of oligodendrocyte differentiation (GO:0048715)2.69071850
81cerebral cortex radially oriented cell migration (GO:0021799)2.68918831
82adult walking behavior (GO:0007628)2.68836308
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67887646
84locomotory exploration behavior (GO:0035641)2.65822537
85regulation of neurotransmitter transport (GO:0051588)2.65714052
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.63856022
87neuron migration (GO:0001764)2.63526140
88positive regulation of synapse maturation (GO:0090129)2.62352616
89diaphragm development (GO:0060539)2.61380795
90neuronal action potential (GO:0019228)2.60379730
91adult behavior (GO:0030534)2.57654386
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57306491
93response to auditory stimulus (GO:0010996)2.56871019
94regulation of dendritic spine morphogenesis (GO:0061001)2.56569795
95arginine catabolic process (GO:0006527)2.55996387
96negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.55400306
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.53037790
98regulation of neurotransmitter secretion (GO:0046928)2.52844023
99sequestering of actin monomers (GO:0042989)2.52690095
100membrane hyperpolarization (GO:0060081)2.51891953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human6.19021995
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.23150172
3GBX2_23144817_ChIP-Seq_PC3_Human3.13338668
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.78208055
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.72089001
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62748519
7ZNF274_21170338_ChIP-Seq_K562_Hela2.61322125
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50207174
9REST_21632747_ChIP-Seq_MESCs_Mouse2.44009435
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42925194
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41584330
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41566701
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40074167
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37810788
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.27676608
16RNF2_27304074_Chip-Seq_NSC_Mouse2.14007778
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12758533
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10291809
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09572429
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05398007
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04024382
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04024382
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.03625754
24TAF15_26573619_Chip-Seq_HEK293_Human2.02995100
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01627997
26DROSHA_22980978_ChIP-Seq_HELA_Human2.00686400
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.99045056
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97826628
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.94979505
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88736882
31FUS_26573619_Chip-Seq_HEK293_Human1.87787031
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87461218
33IGF1R_20145208_ChIP-Seq_DFB_Human1.83764246
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82878105
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72755344
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70115970
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68929521
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67557573
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65623239
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65448739
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64131386
42AR_21572438_ChIP-Seq_LNCaP_Human1.63069520
43P300_19829295_ChIP-Seq_ESCs_Human1.61920713
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60316602
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53940602
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53940602
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50302378
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.49868227
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49847109
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.49747820
51EWS_26573619_Chip-Seq_HEK293_Human1.49071617
52VDR_22108803_ChIP-Seq_LS180_Human1.48288078
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.45514566
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43127510
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41371591
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40791326
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39546071
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.36939804
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35395100
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35314748
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31761865
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31527469
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30702341
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28486212
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.27091131
66AR_25329375_ChIP-Seq_VCAP_Human1.25724260
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25485709
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24644161
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24568155
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23912747
71* STAT3_23295773_ChIP-Seq_U87_Human1.23568796
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20782005
73AR_19668381_ChIP-Seq_PC3_Human1.16400798
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.14894267
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14809450
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13846825
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10535582
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10433657
79SMAD3_21741376_ChIP-Seq_ESCs_Human1.09448110
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08772200
81* TCF4_23295773_ChIP-Seq_U87_Human1.08702060
82CBP_20019798_ChIP-Seq_JUKART_Human1.08097812
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08097812
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07666882
85* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07427941
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07413279
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07082193
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06079706
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.05764577
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04189446
91RUNX2_22187159_ChIP-Seq_PCA_Human1.04101425
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02067301
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01323557
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00137780
95SOX9_26525672_Chip-Seq_HEART_Mouse0.98896087
96JUN_21703547_ChIP-Seq_K562_Human0.97836639
97RARB_27405468_Chip-Seq_BRAIN_Mouse0.97432803
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.95252292
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94468104
100KDM2B_26808549_Chip-Seq_REH_Human0.93514024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.58348695
2MP0004859_abnormal_synaptic_plasticity3.20306444
3MP0003880_abnormal_central_pattern3.19364670
4MP0005423_abnormal_somatic_nervous3.08203892
5MP0002234_abnormal_pharynx_morphology2.75376284
6MP0000778_abnormal_nervous_system2.64575140
7MP0004270_analgesia2.60362301
8MP0003635_abnormal_synaptic_transmissio2.54100973
9MP0009745_abnormal_behavioral_response2.39193285
10MP0002064_seizures2.28864421
11MP0002063_abnormal_learning/memory/cond2.24510833
12MP0005645_abnormal_hypothalamus_physiol2.23981395
13MP0002272_abnormal_nervous_system2.14061748
14MP0001486_abnormal_startle_reflex2.09153041
15MP0003122_maternal_imprinting2.05853246
16MP0003646_muscle_fatigue2.03467550
17MP0002572_abnormal_emotion/affect_behav1.99036418
18MP0002735_abnormal_chemical_nociception1.97013677
19MP0001529_abnormal_vocalization1.88707577
20MP0009046_muscle_twitch1.87672816
21MP0001968_abnormal_touch/_nociception1.86706709
22MP0002734_abnormal_mechanical_nocicepti1.86080779
23MP0001984_abnormal_olfaction1.83225405
24MP0000569_abnormal_digit_pigmentation1.82587361
25MP0004885_abnormal_endolymph1.80229692
26MP0000955_abnormal_spinal_cord1.79843942
27MP0002184_abnormal_innervation1.69636563
28MP0002822_catalepsy1.66398276
29MP0003136_yellow_coat_color1.64599873
30MP0006276_abnormal_autonomic_nervous1.64580660
31MP0004043_abnormal_pH_regulation1.60663495
32MP0002557_abnormal_social/conspecific_i1.58024192
33MP0003283_abnormal_digestive_organ1.56345660
34MP0001970_abnormal_pain_threshold1.56267787
35MP0004811_abnormal_neuron_physiology1.55287585
36MP0002102_abnormal_ear_morphology1.53713622
37MP0004133_heterotaxia1.52795489
38MP0000631_abnormal_neuroendocrine_gland1.51220505
39MP0004742_abnormal_vestibular_system1.47912799
40MP0004142_abnormal_muscle_tone1.46815036
41MP0002736_abnormal_nociception_after1.45673402
42MP0005394_taste/olfaction_phenotype1.44220070
43MP0005499_abnormal_olfactory_system1.44220070
44MP0002067_abnormal_sensory_capabilities1.43521236
45MP0001440_abnormal_grooming_behavior1.42233964
46MP0002882_abnormal_neuron_morphology1.40229687
47MP0000049_abnormal_middle_ear1.32665825
48MP0003938_abnormal_ear_development1.29923315
49MP0001501_abnormal_sleep_pattern1.29288841
50MP0002638_abnormal_pupillary_reflex1.29193619
51MP0004924_abnormal_behavior1.26341976
52MP0005386_behavior/neurological_phenoty1.26341976
53MP0002233_abnormal_nose_morphology1.23524356
54MP0002733_abnormal_thermal_nociception1.22563033
55MP0005187_abnormal_penis_morphology1.21926224
56MP0008789_abnormal_olfactory_epithelium1.20325402
57MP0003937_abnormal_limbs/digits/tail_de1.19949624
58MP0003121_genomic_imprinting1.19816612
59MP0000537_abnormal_urethra_morphology1.19312807
60MP0002152_abnormal_brain_morphology1.19261325
61MP0001188_hyperpigmentation1.17892704
62MP0008569_lethality_at_weaning1.17305203
63MP0000026_abnormal_inner_ear1.14318278
64MP0002752_abnormal_somatic_nervous1.11941566
65MP0004858_abnormal_nervous_system1.10484319
66MP0005646_abnormal_pituitary_gland1.09442119
67MP0002751_abnormal_autonomic_nervous1.08931959
68MP0002066_abnormal_motor_capabilities/c1.07914195
69MP0003861_abnormal_nervous_system1.06774404
70MP0001502_abnormal_circadian_rhythm1.05948758
71MP0003119_abnormal_digestive_system1.05094307
72MP0003787_abnormal_imprinting1.04304717
73MP0002653_abnormal_ependyma_morphology1.03523208
74MP0005171_absent_coat_pigmentation1.00838402
75MP0001485_abnormal_pinna_reflex1.00029357
76MP0005551_abnormal_eye_electrophysiolog0.99186012
77MP0001905_abnormal_dopamine_level0.99107058
78MP0005167_abnormal_blood-brain_barrier0.98870827
79MP0002249_abnormal_larynx_morphology0.96470518
80MP0006292_abnormal_olfactory_placode0.96425340
81MP0003633_abnormal_nervous_system0.96324573
82MP0003631_nervous_system_phenotype0.90104731
83MP0001963_abnormal_hearing_physiology0.86638297
84MP0001177_atelectasis0.86424975
85MP0001299_abnormal_eye_distance/0.84013720
86MP0003632_abnormal_nervous_system0.81304338
87MP0008872_abnormal_physiological_respon0.79937246
88MP0005253_abnormal_eye_physiology0.79503822
89MP0003890_abnormal_embryonic-extraembry0.79302815
90MP0002116_abnormal_craniofacial_bone0.78413244
91MP0009053_abnormal_anal_canal0.78087801
92MP0003755_abnormal_palate_morphology0.77497278
93MP0010030_abnormal_orbit_morphology0.76213032
94MP0000534_abnormal_ureter_morphology0.74266328
95MP0002069_abnormal_eating/drinking_beha0.74071174
96MP0001986_abnormal_taste_sensitivity0.73891492
97MP0006072_abnormal_retinal_apoptosis0.72934888
98MP0005195_abnormal_posterior_eye0.72897146
99MP0008877_abnormal_DNA_methylation0.71438621
100MP0002938_white_spotting0.68909807

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.24061907
2Atonic seizures (HP:0010819)3.73253904
3Focal seizures (HP:0007359)3.62357177
4Hyperventilation (HP:0002883)3.54614166
5Myokymia (HP:0002411)3.29629955
6Febrile seizures (HP:0002373)3.17104504
7Limb dystonia (HP:0002451)2.93241291
8Lissencephaly (HP:0001339)2.92422543
9Drooling (HP:0002307)2.87413855
10Epileptic encephalopathy (HP:0200134)2.85104989
11Polyphagia (HP:0002591)2.80111565
12Gait imbalance (HP:0002141)2.76299517
13Abnormality of the labia minora (HP:0012880)2.76025387
14Pachygyria (HP:0001302)2.65918970
15Progressive cerebellar ataxia (HP:0002073)2.63151036
16Cortical dysplasia (HP:0002539)2.61748077
17Split foot (HP:0001839)2.60499621
18Excessive salivation (HP:0003781)2.60157261
19Type II lissencephaly (HP:0007260)2.56020010
20Abnormal eating behavior (HP:0100738)2.53630047
21Pancreatic cysts (HP:0001737)2.47805526
22Dialeptic seizures (HP:0011146)2.42806927
23Medial flaring of the eyebrow (HP:0010747)2.38402786
24Absence seizures (HP:0002121)2.36277785
25Hemiparesis (HP:0001269)2.35946846
26Absent speech (HP:0001344)2.35047079
27Depressed nasal tip (HP:0000437)2.28759260
28Aplasia involving bones of the extremities (HP:0009825)2.28146580
29Aplasia involving bones of the upper limbs (HP:0009823)2.28146580
30Aplasia of the phalanges of the hand (HP:0009802)2.28146580
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.26835660
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26835660
33Sleep apnea (HP:0010535)2.26350530
34Morphological abnormality of the inner ear (HP:0011390)2.25265696
35Urinary urgency (HP:0000012)2.25180927
36Congenital primary aphakia (HP:0007707)2.24178291
37Abnormality of the corticospinal tract (HP:0002492)2.23667602
38Nephronophthisis (HP:0000090)2.23201998
39Broad-based gait (HP:0002136)2.22623442
40Pheochromocytoma (HP:0002666)2.21707223
41Pancreatic fibrosis (HP:0100732)2.19213613
42Genital tract atresia (HP:0001827)2.18831700
43Retinal dysplasia (HP:0007973)2.18240784
44Aplasia/Hypoplasia of the brainstem (HP:0007362)2.15918717
45Hypoplasia of the brainstem (HP:0002365)2.15918717
46Vaginal atresia (HP:0000148)2.13991378
47Septo-optic dysplasia (HP:0100842)2.13782514
48Nephrogenic diabetes insipidus (HP:0009806)2.11476428
49Amblyopia (HP:0000646)2.11251671
50Specific learning disability (HP:0001328)2.11166848
51Cutaneous finger syndactyly (HP:0010554)2.09163223
52Generalized tonic-clonic seizures (HP:0002069)2.08130402
53True hermaphroditism (HP:0010459)2.07015220
54Epileptiform EEG discharges (HP:0011182)2.06076079
55Optic nerve hypoplasia (HP:0000609)2.02138071
56Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.01648881
57Hypsarrhythmia (HP:0002521)2.01364188
58Esophageal atresia (HP:0002032)2.00979187
59Cerebellar dysplasia (HP:0007033)2.00514307
60Genetic anticipation (HP:0003743)1.97745270
61EEG with generalized epileptiform discharges (HP:0011198)1.95850779
62Action tremor (HP:0002345)1.95786972
63Spastic gait (HP:0002064)1.93243471
64Morphological abnormality of the middle ear (HP:0008609)1.92339270
65Labial hypoplasia (HP:0000066)1.92195778
66Anal stenosis (HP:0002025)1.90802589
67Alacrima (HP:0000522)1.88857842
68Abnormality of the renal medulla (HP:0100957)1.87104878
69Short 5th finger (HP:0009237)1.87026730
70Cupped ear (HP:0000378)1.86684375
71Preaxial foot polydactyly (HP:0001841)1.86604401
72Sparse lateral eyebrow (HP:0005338)1.86366462
73Ulnar claw (HP:0001178)1.84285287
74Status epilepticus (HP:0002133)1.82908069
75Megalencephaly (HP:0001355)1.81567638
76Poor coordination (HP:0002370)1.80454356
77Esotropia (HP:0000565)1.80281389
78Gastrointestinal atresia (HP:0002589)1.79242353
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77721512
80Abnormality of midbrain morphology (HP:0002418)1.77241276
81Molar tooth sign on MRI (HP:0002419)1.77241276
82Gaze-evoked nystagmus (HP:0000640)1.75912096
83Short 4th metacarpal (HP:0010044)1.75585484
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75585484
85Hypoplastic female external genitalia (HP:0012815)1.75511226
86Morphological abnormality of the pyramidal tract (HP:0002062)1.75030398
87Hypoplastic labia majora (HP:0000059)1.73201373
88Oligodactyly (hands) (HP:0001180)1.72964201
89Tented upper lip vermilion (HP:0010804)1.72320083
90Neuroendocrine neoplasm (HP:0100634)1.71966060
91Inability to walk (HP:0002540)1.71393520
92Cutaneous syndactyly (HP:0012725)1.71322609
93Postaxial hand polydactyly (HP:0001162)1.71200484
94Synostosis involving the elbow (HP:0003938)1.71175658
95Humeroradial synostosis (HP:0003041)1.71175658
96Hypoplasia of the corpus callosum (HP:0002079)1.69726399
97Shawl scrotum (HP:0000049)1.69624266
98Concave nail (HP:0001598)1.68617114
99Spastic tetraplegia (HP:0002510)1.68422744
100Ankle clonus (HP:0011448)1.65565772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.82275844
2CASK3.54984154
3NTRK23.46525458
4PINK13.20492908
5MAP3K43.07579754
6PNCK2.93868818
7MAP2K72.73018001
8TNIK2.61242770
9WNK42.49695644
10CCNB12.43964861
11MAPK132.43829804
12STK242.28974237
13STK392.28017350
14EPHA42.26112268
15NTRK32.15421037
16WNK32.06966679
17UHMK11.78311334
18PAK61.73211632
19DAPK21.72277565
20SIK21.67288494
21MINK11.60497639
22DYRK21.52195854
23BCR1.39368129
24MAP2K41.36146597
25PRKCG1.30509861
26ADRBK21.26763007
27FGFR21.17118765
28CAMK41.13546008
29SGK2231.10750088
30SGK4941.10750088
31ERBB31.10041349
32DYRK31.07655251
33CSNK1G21.05335959
34CAMK11.04849091
35ZAK1.02473299
36CAMKK21.00494080
37EPHB20.99940135
38MAP4K20.99221794
39PAK30.96302976
40SGK20.95588593
41PKN10.94991853
42SRPK10.94548772
43CDK50.92178135
44CAMK1G0.91898771
45WEE10.89512609
46MAP3K20.88081498
47CAMKK10.86388327
48TRIM280.85103962
49WNK10.82747369
50MAPK150.81989077
51BMPR1B0.81415698
52CAMK2A0.80405941
53GRK10.78538782
54CSNK1G30.75197215
55DYRK1A0.71967000
56CSNK1A1L0.71770048
57CAMK2B0.71169719
58NTRK10.69390808
59EPHA30.68804830
60PLK20.68783987
61KSR10.67877352
62PHKG10.65239084
63PHKG20.65239084
64FRK0.63435383
65INSRR0.63278543
66DYRK1B0.61751825
67PRKCE0.60218712
68CDK190.59744939
69PRKCZ0.59224748
70CSNK1G10.58493172
71PRKD30.57842852
72RPS6KA60.57103177
73TYRO30.56592241
74CHEK20.52662240
75ILK0.51624409
76MAPKAPK50.45949799
77CAMK1D0.45402780
78STK110.44117758
79RPS6KL10.43541100
80RPS6KC10.43541100
81CDK150.41786543
82CDK180.41783896
83CDK140.40827784
84SGK10.40462625
85ADRBK10.40410182
86ERBB20.39195728
87BCKDK0.38697574
88RPS6KA20.38270892
89CDK11A0.37165535
90PRKACA0.36707204
91BRD40.34218457
92PRKCH0.32169018
93OXSR10.32077119
94CAMK2G0.30503297
95PRKCQ0.30417991
96PRKG10.30376782
97MAP3K60.29930330
98SGK30.27181075
99CSNK1E0.26710974
100PRKACB0.26542965

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.88925310
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.82133844
3GABAergic synapse_Homo sapiens_hsa047272.77046947
4Circadian entrainment_Homo sapiens_hsa047132.75743637
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61021921
6Morphine addiction_Homo sapiens_hsa050322.55791110
7Glutamatergic synapse_Homo sapiens_hsa047242.48706866
8Dopaminergic synapse_Homo sapiens_hsa047282.39222709
9Phototransduction_Homo sapiens_hsa047442.30081737
10Synaptic vesicle cycle_Homo sapiens_hsa047212.25243814
11Cocaine addiction_Homo sapiens_hsa050302.18107740
12Taste transduction_Homo sapiens_hsa047422.16789244
13Amphetamine addiction_Homo sapiens_hsa050312.03680547
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75202430
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69408746
16Axon guidance_Homo sapiens_hsa043601.68623821
17Long-term depression_Homo sapiens_hsa047301.64606261
18Insulin secretion_Homo sapiens_hsa049111.61743994
19Cholinergic synapse_Homo sapiens_hsa047251.53237229
20Cardiac muscle contraction_Homo sapiens_hsa042601.51915749
21Hedgehog signaling pathway_Homo sapiens_hsa043401.45974730
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44300558
23Salivary secretion_Homo sapiens_hsa049701.42911967
24Olfactory transduction_Homo sapiens_hsa047401.42739220
25Basal cell carcinoma_Homo sapiens_hsa052171.30024916
26Gastric acid secretion_Homo sapiens_hsa049711.27177118
27Serotonergic synapse_Homo sapiens_hsa047261.27008729
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22816394
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22584137
30cAMP signaling pathway_Homo sapiens_hsa040241.18403223
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17200799
32Calcium signaling pathway_Homo sapiens_hsa040201.16229749
33Long-term potentiation_Homo sapiens_hsa047201.15574147
34Oxytocin signaling pathway_Homo sapiens_hsa049211.14841772
35Gap junction_Homo sapiens_hsa045401.12614994
36Butanoate metabolism_Homo sapiens_hsa006501.11544593
37Hippo signaling pathway_Homo sapiens_hsa043901.06385927
38Melanogenesis_Homo sapiens_hsa049161.06111263
39Nitrogen metabolism_Homo sapiens_hsa009101.05855879
40Oxidative phosphorylation_Homo sapiens_hsa001901.02128464
41Alcoholism_Homo sapiens_hsa050341.01039878
42Parkinsons disease_Homo sapiens_hsa050121.00520387
43Arginine biosynthesis_Homo sapiens_hsa002200.99682256
44Alzheimers disease_Homo sapiens_hsa050100.96082080
45Renin secretion_Homo sapiens_hsa049240.95905163
46Collecting duct acid secretion_Homo sapiens_hsa049660.86035629
47AMPK signaling pathway_Homo sapiens_hsa041520.82143220
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79388460
49Linoleic acid metabolism_Homo sapiens_hsa005910.76451209
50beta-Alanine metabolism_Homo sapiens_hsa004100.74229809
51Estrogen signaling pathway_Homo sapiens_hsa049150.72609410
52Oocyte meiosis_Homo sapiens_hsa041140.70577080
53Ether lipid metabolism_Homo sapiens_hsa005650.69969340
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69690135
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68209150
56Wnt signaling pathway_Homo sapiens_hsa043100.67751720
57Type II diabetes mellitus_Homo sapiens_hsa049300.67167574
58Circadian rhythm_Homo sapiens_hsa047100.66390379
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66267139
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65901374
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65571643
62Huntingtons disease_Homo sapiens_hsa050160.65459401
63Ras signaling pathway_Homo sapiens_hsa040140.64423495
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62929449
65ErbB signaling pathway_Homo sapiens_hsa040120.62590917
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57071994
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.56462984
68Rap1 signaling pathway_Homo sapiens_hsa040150.56134029
69Regulation of autophagy_Homo sapiens_hsa041400.55602184
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54943852
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53996957
72Arginine and proline metabolism_Homo sapiens_hsa003300.52727765
73Steroid biosynthesis_Homo sapiens_hsa001000.52417716
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51845001
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51768023
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50201893
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50109506
78Lysine degradation_Homo sapiens_hsa003100.50104678
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49591309
80Ovarian steroidogenesis_Homo sapiens_hsa049130.49254057
81MAPK signaling pathway_Homo sapiens_hsa040100.48834961
82Bile secretion_Homo sapiens_hsa049760.46703767
83Dorso-ventral axis formation_Homo sapiens_hsa043200.46354454
84Selenocompound metabolism_Homo sapiens_hsa004500.46161974
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46008996
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45919157
87Thyroid hormone synthesis_Homo sapiens_hsa049180.45264090
88Dilated cardiomyopathy_Homo sapiens_hsa054140.45257904
89GnRH signaling pathway_Homo sapiens_hsa049120.43447354
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41554318
91Histidine metabolism_Homo sapiens_hsa003400.41267697
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.41132688
93Fanconi anemia pathway_Homo sapiens_hsa034600.40908407
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.40492654
95Protein export_Homo sapiens_hsa030600.38412317
96TGF-beta signaling pathway_Homo sapiens_hsa043500.38143673
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37484479
98Glioma_Homo sapiens_hsa052140.36507693
99ABC transporters_Homo sapiens_hsa020100.35988619
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.33336675

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