ZNF532

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.46225159
2presynaptic membrane organization (GO:0097090)4.32409129
3pyrimidine nucleobase catabolic process (GO:0006208)4.12720090
4neuron recognition (GO:0008038)3.66122986
5postsynaptic membrane organization (GO:0001941)3.65044257
6lateral sprouting from an epithelium (GO:0060601)3.62871864
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60249204
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.60249204
9regulation of translation, ncRNA-mediated (GO:0045974)3.60249204
10neuronal stem cell maintenance (GO:0097150)3.56038112
11axonal fasciculation (GO:0007413)3.53983566
12neuron cell-cell adhesion (GO:0007158)3.47447656
13axon extension involved in axon guidance (GO:0048846)3.42610991
14neuron projection extension involved in neuron projection guidance (GO:1902284)3.42610991
15regulation of gene silencing by RNA (GO:0060966)3.35528771
16regulation of posttranscriptional gene silencing (GO:0060147)3.35528771
17regulation of gene silencing by miRNA (GO:0060964)3.35528771
18vocalization behavior (GO:0071625)3.32989285
19paraxial mesoderm development (GO:0048339)3.29024133
20limb bud formation (GO:0060174)3.17474971
21nucleobase catabolic process (GO:0046113)3.12578253
22transmission of nerve impulse (GO:0019226)3.07972054
23regulation of timing of cell differentiation (GO:0048505)3.03710706
24negative regulation of axon guidance (GO:1902668)2.99124894
25regulation of development, heterochronic (GO:0040034)2.99025020
26spinal cord development (GO:0021510)2.95472432
27retinal ganglion cell axon guidance (GO:0031290)2.94336702
28positive regulation of synapse assembly (GO:0051965)2.92437384
29negative regulation of oligodendrocyte differentiation (GO:0048715)2.87789505
30establishment of nucleus localization (GO:0040023)2.85105216
31regulation of axon guidance (GO:1902667)2.84340163
32somite development (GO:0061053)2.78136580
33central nervous system projection neuron axonogenesis (GO:0021952)2.73006314
34cerebellar granule cell differentiation (GO:0021707)2.71611825
35artery development (GO:0060840)2.71539652
36cell proliferation in forebrain (GO:0021846)2.71347181
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68951649
38kidney morphogenesis (GO:0060993)2.67746110
39forebrain neuron differentiation (GO:0021879)2.64882219
40innervation (GO:0060384)2.63673678
41outer ear morphogenesis (GO:0042473)2.63442353
42protein localization to synapse (GO:0035418)2.62890246
43cochlea development (GO:0090102)2.62503796
44negative regulation of axon extension involved in axon guidance (GO:0048843)2.60022813
45regulation of synapse assembly (GO:0051963)2.59932528
46dendritic spine morphogenesis (GO:0060997)2.59757963
47convergent extension (GO:0060026)2.59110309
48negative chemotaxis (GO:0050919)2.58986354
49regulation of axon extension involved in axon guidance (GO:0048841)2.58907617
50planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55764279
51calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53401028
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53301831
53regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52172784
54establishment of tissue polarity (GO:0007164)2.51772998
55establishment of planar polarity (GO:0001736)2.51772998
56neuron fate determination (GO:0048664)2.51496568
57cell migration in hindbrain (GO:0021535)2.50275813
58cerebral cortex radially oriented cell migration (GO:0021799)2.49884028
59lung-associated mesenchyme development (GO:0060484)2.47598169
60tongue development (GO:0043586)2.47105730
61axon extension (GO:0048675)2.46835270
62synapse assembly (GO:0007416)2.46554574
63negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.45337134
64auditory behavior (GO:0031223)2.44884295
65limb development (GO:0060173)2.43005995
66appendage development (GO:0048736)2.43005995
67substrate-independent telencephalic tangential migration (GO:0021826)2.43004140
68substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.43004140
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42944567
70apical protein localization (GO:0045176)2.40350681
71dermatan sulfate biosynthetic process (GO:0030208)2.39339227
72nonmotile primary cilium assembly (GO:0035058)2.39306638
73dendrite morphogenesis (GO:0048813)2.38009383
74ephrin receptor signaling pathway (GO:0048013)2.37796305
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37380068
76asymmetric protein localization (GO:0008105)2.35898059
77cranial nerve development (GO:0021545)2.33951625
78olfactory bulb development (GO:0021772)2.33640574
79central nervous system neuron axonogenesis (GO:0021955)2.33226011
80non-canonical Wnt signaling pathway (GO:0035567)2.32495839
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31537745
82astrocyte development (GO:0014002)2.30955413
83negative regulation of glial cell differentiation (GO:0045686)2.30448744
84otic vesicle formation (GO:0030916)2.30283551
85axon ensheathment in central nervous system (GO:0032291)2.29788189
86central nervous system myelination (GO:0022010)2.29788189
87positive regulation of neuroblast proliferation (GO:0002052)2.29699917
88ionotropic glutamate receptor signaling pathway (GO:0035235)2.29091198
89lens fiber cell development (GO:0070307)2.28969894
90adult walking behavior (GO:0007628)2.28232522
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.26704972
92notochord development (GO:0030903)2.26260947
93pre-miRNA processing (GO:0031054)2.25746117
94gamma-aminobutyric acid transport (GO:0015812)2.24478710
95synapse organization (GO:0050808)2.24156542
96generation of neurons (GO:0048699)2.21584186
97cell-cell signaling involved in cell fate commitment (GO:0045168)2.20695135
98cell migration involved in sprouting angiogenesis (GO:0002042)2.18709748
99dorsal/ventral axis specification (GO:0009950)2.18554786
100head development (GO:0060322)2.17919711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.36319361
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.49061787
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.21430390
4GBX2_23144817_ChIP-Seq_PC3_Human3.17508359
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54072953
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24269416
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20875564
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16399494
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.05506440
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01886568
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.00501409
12SALL1_21062744_ChIP-ChIP_HESCs_Human1.98282793
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95457726
14PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91218592
15* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90900684
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.89042908
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87715111
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86239730
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.84513176
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83485805
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83031776
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82283887
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82035749
24ZNF274_21170338_ChIP-Seq_K562_Hela1.81886805
25TAF15_26573619_Chip-Seq_HEK293_Human1.80237637
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79494609
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79494609
28P300_19829295_ChIP-Seq_ESCs_Human1.78596405
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72424995
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70156474
31FUS_26573619_Chip-Seq_HEK293_Human1.68597808
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.67139786
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63959498
34SMAD4_21799915_ChIP-Seq_A2780_Human1.62002215
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59937946
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57815682
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57334910
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54774221
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54397684
40* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53036419
41REST_21632747_ChIP-Seq_MESCs_Mouse1.52937378
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51765123
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51765123
44IGF1R_20145208_ChIP-Seq_DFB_Human1.50828075
45AR_21572438_ChIP-Seq_LNCaP_Human1.50473720
46RNF2_27304074_Chip-Seq_NSC_Mouse1.49924263
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49099623
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48768025
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46693661
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46271129
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45642980
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44781060
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44305357
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40388137
55EWS_26573619_Chip-Seq_HEK293_Human1.39896720
56VDR_22108803_ChIP-Seq_LS180_Human1.39215861
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38997399
58STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38395078
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37431081
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36873230
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36506551
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.36145817
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.35051256
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32839536
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32590786
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32444875
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.30572930
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29867602
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27973844
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.26054241
71STAT3_23295773_ChIP-Seq_U87_Human1.25669520
72SOX9_26525672_Chip-Seq_HEART_Mouse1.24836046
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22912135
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.22743535
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.22269146
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22203577
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21446357
78DROSHA_22980978_ChIP-Seq_HELA_Human1.21277229
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20584890
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20207498
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19647478
82AR_25329375_ChIP-Seq_VCAP_Human1.19161905
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18157477
84* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17146515
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16544953
86* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15278920
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15048897
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.14495989
89TCF4_23295773_ChIP-Seq_U87_Human1.12684054
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12201716
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.10299812
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10215080
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10018592
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09222805
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08991962
96SMAD3_21741376_ChIP-Seq_ESCs_Human1.08159019
97RUNX2_22187159_ChIP-Seq_PCA_Human1.07471279
98KDM2B_26808549_Chip-Seq_REH_Human1.06402232
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.05642189
100AR_19668381_ChIP-Seq_PC3_Human1.04842614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.37064612
2MP0003136_yellow_coat_color2.78322611
3MP0000778_abnormal_nervous_system2.64657650
4MP0004859_abnormal_synaptic_plasticity2.11767377
5MP0003122_maternal_imprinting1.99886180
6MP0004270_analgesia1.98430069
7MP0002653_abnormal_ependyma_morphology1.92806642
8MP0000566_synostosis1.80716581
9MP0010030_abnormal_orbit_morphology1.79960051
10MP0006292_abnormal_olfactory_placode1.77466664
11MP0000049_abnormal_middle_ear1.74564701
12MP0004133_heterotaxia1.71459193
13MP0003890_abnormal_embryonic-extraembry1.69095629
14MP0002102_abnormal_ear_morphology1.68009440
15MP0001299_abnormal_eye_distance/1.64523059
16MP0001984_abnormal_olfaction1.64009673
17MP0008789_abnormal_olfactory_epithelium1.63571473
18MP0003119_abnormal_digestive_system1.57781183
19MP0005394_taste/olfaction_phenotype1.56293356
20MP0005499_abnormal_olfactory_system1.56293356
21MP0003937_abnormal_limbs/digits/tail_de1.55434094
22MP0001293_anophthalmia1.55399782
23MP0003635_abnormal_synaptic_transmissio1.51446464
24MP0003121_genomic_imprinting1.51064395
25MP0003283_abnormal_digestive_organ1.50508495
26MP0000955_abnormal_spinal_cord1.44238536
27MP0005423_abnormal_somatic_nervous1.43279261
28MP0002233_abnormal_nose_morphology1.43276806
29MP0002751_abnormal_autonomic_nervous1.42116256
30MP0001529_abnormal_vocalization1.41071816
31MP0003861_abnormal_nervous_system1.40521719
32MP0004885_abnormal_endolymph1.38770736
33MP0002938_white_spotting1.38765211
34MP0000579_abnormal_nail_morphology1.38476394
35MP0000631_abnormal_neuroendocrine_gland1.37511176
36MP0002734_abnormal_mechanical_nocicepti1.37253136
37MP0003755_abnormal_palate_morphology1.37055284
38MP0001486_abnormal_startle_reflex1.35825180
39MP0002184_abnormal_innervation1.34531426
40MP0002697_abnormal_eye_size1.32866384
41MP0003938_abnormal_ear_development1.32349382
42MP0000534_abnormal_ureter_morphology1.30865223
43MP0000537_abnormal_urethra_morphology1.29150059
44MP0002234_abnormal_pharynx_morphology1.27743561
45MP0003941_abnormal_skin_development1.26747277
46MP0002063_abnormal_learning/memory/cond1.26084326
47MP0000569_abnormal_digit_pigmentation1.24732780
48MP0003942_abnormal_urinary_system1.22823049
49MP0001286_abnormal_eye_development1.22462287
50MP0008877_abnormal_DNA_methylation1.21466897
51MP0006276_abnormal_autonomic_nervous1.18936186
52MP0002272_abnormal_nervous_system1.18726237
53MP0000428_abnormal_craniofacial_morphol1.18527216
54MP0005503_abnormal_tendon_morphology1.17589006
55MP0009053_abnormal_anal_canal1.16923362
56MP0003385_abnormal_body_wall1.15541965
57MP0003787_abnormal_imprinting1.15201855
58MP0002152_abnormal_brain_morphology1.14852300
59MP0000026_abnormal_inner_ear1.14640259
60MP0001485_abnormal_pinna_reflex1.14388863
61MP0009250_abnormal_appendicular_skeleto1.14383920
62MP0009745_abnormal_behavioral_response1.13638985
63MP0002572_abnormal_emotion/affect_behav1.13561181
64MP0002735_abnormal_chemical_nociception1.13122486
65MP0003935_abnormal_craniofacial_develop1.11717824
66MP0004272_abnormal_basement_membrane1.10526760
67MP0009384_cardiac_valve_regurgitation1.10451653
68MP0002882_abnormal_neuron_morphology1.09163904
69MP0002116_abnormal_craniofacial_bone1.08875156
70MP0002557_abnormal_social/conspecific_i1.07955468
71MP0000762_abnormal_tongue_morphology1.07827422
72MP0000432_abnormal_head_morphology1.06281653
73MP0009046_muscle_twitch1.06210787
74MP0006072_abnormal_retinal_apoptosis1.05365111
75MP0002736_abnormal_nociception_after1.04575118
76MP0000383_abnormal_hair_follicle1.03995762
77MP0002064_seizures1.02893332
78MP0000751_myopathy1.01334904
79MP0002752_abnormal_somatic_nervous0.99931156
80MP0001177_atelectasis0.98376254
81MP0001968_abnormal_touch/_nociception0.97960692
82MP0002249_abnormal_larynx_morphology0.93976707
83MP0002081_perinatal_lethality0.92745694
84MP0004145_abnormal_muscle_electrophysio0.91961800
85MP0002108_abnormal_muscle_morphology0.91261517
86MP0002638_abnormal_pupillary_reflex0.90575675
87MP0005253_abnormal_eye_physiology0.89865830
88MP0004811_abnormal_neuron_physiology0.89398453
89MP0002822_catalepsy0.88971632
90MP0002067_abnormal_sensory_capabilities0.88575572
91MP0001188_hyperpigmentation0.88208039
92MP0005391_vision/eye_phenotype0.86773275
93MP0004142_abnormal_muscle_tone0.85926642
94MP0002282_abnormal_trachea_morphology0.85905976
95MP0002111_abnormal_tail_morphology0.84518790
96MP0005187_abnormal_penis_morphology0.83448436
97MP0005551_abnormal_eye_electrophysiolog0.82770586
98MP0002932_abnormal_joint_morphology0.82014432
99MP0001970_abnormal_pain_threshold0.81028009
100MP0004215_abnormal_myocardial_fiber0.80411099

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.01747576
2Abnormality of the labia minora (HP:0012880)2.85577773
3Split foot (HP:0001839)2.75529991
4Hepatoblastoma (HP:0002884)2.50937600
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50791893
6Cutaneous finger syndactyly (HP:0010554)2.48667572
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34280554
8Short 4th metacarpal (HP:0010044)2.34280554
9Optic nerve hypoplasia (HP:0000609)2.33349480
10Oligodactyly (hands) (HP:0001180)2.32604129
11Genetic anticipation (HP:0003743)2.26127702
12Vitreoretinal degeneration (HP:0000655)2.24679900
13Cutaneous syndactyly (HP:0012725)2.24016627
14Progressive cerebellar ataxia (HP:0002073)2.21047635
15Abnormality of the pubic bones (HP:0003172)2.20815851
16Drooling (HP:0002307)2.18335333
17Preaxial foot polydactyly (HP:0001841)2.16680090
18Gastrointestinal atresia (HP:0002589)2.14640543
19Anophthalmia (HP:0000528)2.13719175
20Pancreatic fibrosis (HP:0100732)2.10093959
21Coronal craniosynostosis (HP:0004440)2.08231718
22Shallow orbits (HP:0000586)2.08093430
23Abnormality of abdominal situs (HP:0011620)2.06420497
24Abdominal situs inversus (HP:0003363)2.06420497
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05964691
26Genital tract atresia (HP:0001827)2.04564647
27Humeroradial synostosis (HP:0003041)2.02619663
28Synostosis involving the elbow (HP:0003938)2.02619663
29Esophageal atresia (HP:0002032)2.01838966
30Morphological abnormality of the middle ear (HP:0008609)1.96220648
31Broad metatarsal (HP:0001783)1.95050517
32Aplasia/Hypoplasia of the sternum (HP:0006714)1.94773672
33Broad-based gait (HP:0002136)1.94115927
34Hypoplastic pelvis (HP:0008839)1.93837021
35Synostosis involving bones of the feet (HP:0009140)1.93709048
36Synostosis involving bones of the lower limbs (HP:0009138)1.93709048
37Cortical dysplasia (HP:0002539)1.93627464
38Abnormality of the ischium (HP:0003174)1.93341265
39Hyperventilation (HP:0002883)1.92311327
40Intestinal atresia (HP:0011100)1.91400693
41Vaginal atresia (HP:0000148)1.90593275
42Renal hypoplasia (HP:0000089)1.90295300
43Hemivertebrae (HP:0002937)1.89884244
44Colon cancer (HP:0003003)1.89111164
45Excessive salivation (HP:0003781)1.88544201
46Oligodactyly (HP:0012165)1.86052511
47Bilateral microphthalmos (HP:0007633)1.84073554
48True hermaphroditism (HP:0010459)1.83056824
49Abnormality of the 4th metacarpal (HP:0010012)1.82268220
50Limb dystonia (HP:0002451)1.80199536
51Maternal diabetes (HP:0009800)1.78050255
52Focal seizures (HP:0007359)1.77907013
53Turricephaly (HP:0000262)1.76889718
54Absent septum pellucidum (HP:0001331)1.75838261
55Focal motor seizures (HP:0011153)1.75750843
56Bifid tongue (HP:0010297)1.74682448
57Skull defect (HP:0001362)1.73926118
58Aqueductal stenosis (HP:0002410)1.72693479
59Myokymia (HP:0002411)1.72617154
60Postaxial hand polydactyly (HP:0001162)1.72612821
61Bronchomalacia (HP:0002780)1.72574582
62Lissencephaly (HP:0001339)1.72569138
63Gait imbalance (HP:0002141)1.72295520
64Tarsal synostosis (HP:0008368)1.71944181
65High anterior hairline (HP:0009890)1.71592503
66Trigonocephaly (HP:0000243)1.71396053
67Aplasia involving bones of the extremities (HP:0009825)1.71238052
68Aplasia involving bones of the upper limbs (HP:0009823)1.71238052
69Aplasia of the phalanges of the hand (HP:0009802)1.71238052
70Renal dysplasia (HP:0000110)1.70784323
71Labial hypoplasia (HP:0000066)1.69847037
72Rib fusion (HP:0000902)1.69207481
73Abnormality of the diencephalon (HP:0010662)1.68805104
74Synostosis of carpal bones (HP:0005048)1.68466432
75Pancreatic cysts (HP:0001737)1.67825250
76Pachygyria (HP:0001302)1.67737936
77Micropenis (HP:0000054)1.67436599
78Choanal stenosis (HP:0000452)1.66465082
79Specific learning disability (HP:0001328)1.65970134
80Fibular aplasia (HP:0002990)1.65945947
81Nephronophthisis (HP:0000090)1.65917164
82Adactyly (HP:0009776)1.65810086
83Hypoplastic nipples (HP:0002557)1.65673024
84Midline defect of the nose (HP:0004122)1.64919023
85Abnormality of the septum pellucidum (HP:0007375)1.63564626
86Aplasia/Hypoplasia of the fibula (HP:0006492)1.63111197
87Megalencephaly (HP:0001355)1.62311834
88Sleep apnea (HP:0010535)1.60633340
89Short foot (HP:0001773)1.60475164
90Broad thumb (HP:0011304)1.59752850
91Shawl scrotum (HP:0000049)1.58354330
92Protruding tongue (HP:0010808)1.58224897
93Hypoplastic ischia (HP:0003175)1.56281607
94Abnormality of the lower motor neuron (HP:0002366)1.55489067
95Broad foot (HP:0001769)1.54976672
96Medial flaring of the eyebrow (HP:0010747)1.54578769
97Wide anterior fontanel (HP:0000260)1.54300991
98Abnormality of the renal medulla (HP:0100957)1.52988729
99Hypoplastic labia majora (HP:0000059)1.52951977
100Abnormality of midbrain morphology (HP:0002418)1.52889593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.83430633
2TNIK3.70281737
3CASK3.63667046
4NTRK22.36310992
5MAP3K42.27553426
6PNCK2.15171294
7WNK32.12053590
8EPHA42.04655162
9NTRK12.02958227
10EPHB21.96468680
11FGFR21.88437911
12DYRK21.82854592
13BCR1.69923572
14NTRK31.66347201
15CAMK1G1.60822034
16MKNK21.58665000
17STK38L1.53745532
18LATS11.51137975
19EPHA31.42487886
20MAP2K71.38925021
21MAPK131.32638127
22MKNK11.28395347
23CAMK1D1.27184982
24SGK21.27093476
25BMPR1B1.25921505
26PINK11.25152818
27SGK2231.23797387
28SGK4941.23797387
29FRK1.18757915
30TAF11.17615340
31TYRO31.12784032
32OBSCN1.02312269
33CSNK1G20.97019404
34UHMK10.94708167
35LATS20.93911873
36PLK20.93430772
37MAP3K100.93135409
38TRIM280.92744514
39TIE10.90436817
40PDGFRA0.89558394
41TSSK60.87845655
42MINK10.86585754
43PRKCG0.86078640
44INSRR0.85552330
45PKN10.84867277
46PAK30.84542377
47PRKCE0.83701296
48DYRK1A0.83139978
49ERBB30.81841024
50CSNK1G10.80808748
51MAP4K20.80759254
52CDK190.80417690
53DYRK30.80334981
54TGFBR10.80134401
55MAPK150.78294537
56AKT30.76910947
57PHKG20.75810708
58PHKG10.75810708
59CDK50.72352845
60FGFR10.72314150
61ERBB20.70525210
62MET0.69513458
63KSR10.68779465
64ERBB40.68522421
65BRD40.66861451
66PAK60.65882104
67CDK30.65785529
68CSNK1A1L0.65133162
69PLK30.64835759
70CAMK2A0.63364254
71SGK30.62559325
72STK30.62149588
73CAMK10.61910396
74ROCK10.57599203
75WEE10.56076584
76CSNK1G30.56020752
77CAMK2B0.55904111
78CDC70.55799186
79ROCK20.53929436
80OXSR10.53587450
81GRK10.53567137
82MAP2K40.53038253
83MAP3K90.52134536
84STK110.50417355
85DDR20.50361379
86DMPK0.49671808
87SRPK10.47409073
88PAK20.44816659
89PRKCZ0.44307290
90NEK10.43990998
91ADRBK20.43120167
92CSNK1E0.42557991
93NEK20.42395335
94TTK0.42301292
95PRKDC0.40823877
96ZAK0.40662273
97CAMK40.40544072
98CDK180.40127240
99PRKD30.40052397
100PDGFRB0.39703390

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.95366081
2Basal cell carcinoma_Homo sapiens_hsa052172.72873146
3Hedgehog signaling pathway_Homo sapiens_hsa043402.37756600
4Axon guidance_Homo sapiens_hsa043602.37540012
5Hippo signaling pathway_Homo sapiens_hsa043902.12365039
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98831555
7Glutamatergic synapse_Homo sapiens_hsa047241.94912272
8Cocaine addiction_Homo sapiens_hsa050301.85725931
9GABAergic synapse_Homo sapiens_hsa047271.82768742
10Circadian entrainment_Homo sapiens_hsa047131.82050683
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.73166333
12Morphine addiction_Homo sapiens_hsa050321.72587830
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71286304
14Taste transduction_Homo sapiens_hsa047421.65459502
15Dopaminergic synapse_Homo sapiens_hsa047281.64620616
16Wnt signaling pathway_Homo sapiens_hsa043101.62743842
17Dilated cardiomyopathy_Homo sapiens_hsa054141.59943718
18Amphetamine addiction_Homo sapiens_hsa050311.56771436
19Melanogenesis_Homo sapiens_hsa049161.55214505
20ECM-receptor interaction_Homo sapiens_hsa045121.54726653
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54213693
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51021839
23Phototransduction_Homo sapiens_hsa047441.48089293
24Insulin secretion_Homo sapiens_hsa049111.47059442
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46036010
26Adherens junction_Homo sapiens_hsa045201.40275929
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37019111
28Tight junction_Homo sapiens_hsa045301.32651335
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27317892
30Long-term depression_Homo sapiens_hsa047301.27166003
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25426647
32Gap junction_Homo sapiens_hsa045401.22255750
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21957997
34TGF-beta signaling pathway_Homo sapiens_hsa043501.18893891
35Cholinergic synapse_Homo sapiens_hsa047251.16331167
36cAMP signaling pathway_Homo sapiens_hsa040241.14342722
37Cardiac muscle contraction_Homo sapiens_hsa042601.13790987
38Notch signaling pathway_Homo sapiens_hsa043301.09503229
39Serotonergic synapse_Homo sapiens_hsa047261.08046553
40Renin secretion_Homo sapiens_hsa049241.06755632
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04345711
42Propanoate metabolism_Homo sapiens_hsa006401.03448449
43Steroid biosynthesis_Homo sapiens_hsa001001.02291547
44Calcium signaling pathway_Homo sapiens_hsa040201.01544751
45Protein digestion and absorption_Homo sapiens_hsa049740.99484838
46Oxytocin signaling pathway_Homo sapiens_hsa049210.98939483
47Lysine degradation_Homo sapiens_hsa003100.96293207
48Gastric acid secretion_Homo sapiens_hsa049710.93636127
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91817560
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91731731
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88405896
52MicroRNAs in cancer_Homo sapiens_hsa052060.86508805
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.86311961
54Olfactory transduction_Homo sapiens_hsa047400.85086753
55Salivary secretion_Homo sapiens_hsa049700.83508630
56Focal adhesion_Homo sapiens_hsa045100.83374418
57Oocyte meiosis_Homo sapiens_hsa041140.82207555
58Ether lipid metabolism_Homo sapiens_hsa005650.81083871
59Selenocompound metabolism_Homo sapiens_hsa004500.80605554
60Circadian rhythm_Homo sapiens_hsa047100.80446250
61Dorso-ventral axis formation_Homo sapiens_hsa043200.80392601
62Rap1 signaling pathway_Homo sapiens_hsa040150.79330175
63Long-term potentiation_Homo sapiens_hsa047200.76941481
64Estrogen signaling pathway_Homo sapiens_hsa049150.75946094
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75307984
66Synaptic vesicle cycle_Homo sapiens_hsa047210.73801582
67Basal transcription factors_Homo sapiens_hsa030220.72779880
68mRNA surveillance pathway_Homo sapiens_hsa030150.71224936
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71013393
70Melanoma_Homo sapiens_hsa052180.68748195
71Colorectal cancer_Homo sapiens_hsa052100.68215342
72Pathways in cancer_Homo sapiens_hsa052000.68122620
73Ras signaling pathway_Homo sapiens_hsa040140.67732437
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67100637
75Butanoate metabolism_Homo sapiens_hsa006500.66227108
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65050506
77Fanconi anemia pathway_Homo sapiens_hsa034600.64233793
78Thyroid hormone synthesis_Homo sapiens_hsa049180.63155930
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60651741
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.57363550
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55645550
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53961175
83beta-Alanine metabolism_Homo sapiens_hsa004100.53628926
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53557339
85Glucagon signaling pathway_Homo sapiens_hsa049220.52208903
86Non-homologous end-joining_Homo sapiens_hsa034500.51677288
87AMPK signaling pathway_Homo sapiens_hsa041520.49967413
88RNA degradation_Homo sapiens_hsa030180.49657484
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49394225
90Proteoglycans in cancer_Homo sapiens_hsa052050.49315464
91Alcoholism_Homo sapiens_hsa050340.48712381
92Protein export_Homo sapiens_hsa030600.47677964
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47331869
94Ovarian steroidogenesis_Homo sapiens_hsa049130.47139095
95Linoleic acid metabolism_Homo sapiens_hsa005910.46587645
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.45161528
97Type II diabetes mellitus_Homo sapiens_hsa049300.44312595
98ErbB signaling pathway_Homo sapiens_hsa040120.44106252
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44100866
100Endometrial cancer_Homo sapiens_hsa052130.44079526

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