ZNF529

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.26801353
2neural tube formation (GO:0001841)3.82294919
3behavioral response to nicotine (GO:0035095)3.81771640
4detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.64400079
5neuronal action potential propagation (GO:0019227)3.63818348
6fucose catabolic process (GO:0019317)3.58876816
7L-fucose metabolic process (GO:0042354)3.58876816
8L-fucose catabolic process (GO:0042355)3.58876816
9protein K11-linked deubiquitination (GO:0035871)3.53390675
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50385322
11pyrimidine nucleobase catabolic process (GO:0006208)3.44791102
12behavioral response to ethanol (GO:0048149)3.32879846
13protein localization to cilium (GO:0061512)3.32117182
14gamma-aminobutyric acid transport (GO:0015812)3.25419565
15nonmotile primary cilium assembly (GO:0035058)3.20637564
16kynurenine metabolic process (GO:0070189)3.10088757
17regulation of cilium movement (GO:0003352)3.05141717
18histone H3-K9 methylation (GO:0051567)3.03771934
19presynaptic membrane assembly (GO:0097105)3.03662093
20tryptophan catabolic process (GO:0006569)3.00631000
21indole-containing compound catabolic process (GO:0042436)3.00631000
22indolalkylamine catabolic process (GO:0046218)3.00631000
23epithelial cilium movement (GO:0003351)3.00509747
24cilium or flagellum-dependent cell motility (GO:0001539)2.98889531
25indolalkylamine metabolic process (GO:0006586)2.98521336
26axoneme assembly (GO:0035082)2.96033419
27nucleobase catabolic process (GO:0046113)2.95640353
28neurotransmitter-gated ion channel clustering (GO:0072578)2.94532581
29negative regulation of telomere maintenance (GO:0032205)2.93658184
30cilium organization (GO:0044782)2.91436043
31negative regulation of translation, ncRNA-mediated (GO:0040033)2.90437885
32regulation of translation, ncRNA-mediated (GO:0045974)2.90437885
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90437885
34protein import into peroxisome matrix (GO:0016558)2.87823665
35cilium assembly (GO:0042384)2.87164330
36detection of light stimulus involved in sensory perception (GO:0050962)2.85954526
37detection of light stimulus involved in visual perception (GO:0050908)2.85954526
38negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85063301
39inner ear receptor stereocilium organization (GO:0060122)2.83822750
40piRNA metabolic process (GO:0034587)2.83518151
41auditory receptor cell stereocilium organization (GO:0060088)2.78741940
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76181948
43reciprocal meiotic recombination (GO:0007131)2.75437856
44reciprocal DNA recombination (GO:0035825)2.75437856
45regulation of telomere maintenance (GO:0032204)2.75328552
46protein polyglutamylation (GO:0018095)2.74570644
47tryptophan metabolic process (GO:0006568)2.71698940
48protein-cofactor linkage (GO:0018065)2.71670781
49cilium movement (GO:0003341)2.71418969
50glycosphingolipid biosynthetic process (GO:0006688)2.70463951
51presynaptic membrane organization (GO:0097090)2.69984678
52kidney morphogenesis (GO:0060993)2.69011154
53retinal cone cell development (GO:0046549)2.66751810
54DNA double-strand break processing (GO:0000729)2.66121705
55cilium morphogenesis (GO:0060271)2.64540853
56interkinetic nuclear migration (GO:0022027)2.64073516
57neuronal action potential (GO:0019228)2.63378968
58reflex (GO:0060004)2.62412514
59intraciliary transport (GO:0042073)2.58700859
60cellular ketone body metabolic process (GO:0046950)2.55402342
61replication fork processing (GO:0031297)2.55297639
62establishment of protein localization to Golgi (GO:0072600)2.53140204
63cornea development in camera-type eye (GO:0061303)2.51571828
64sulfation (GO:0051923)2.51567769
65retinal ganglion cell axon guidance (GO:0031290)2.51244344
66centriole replication (GO:0007099)2.51236113
67positive regulation of oligodendrocyte differentiation (GO:0048714)2.51134684
68glycerophospholipid catabolic process (GO:0046475)2.47739511
69auditory behavior (GO:0031223)2.47076040
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.44923029
71startle response (GO:0001964)2.42697129
72photoreceptor cell development (GO:0042461)2.41945825
73photoreceptor cell maintenance (GO:0045494)2.40668283
74neuron cell-cell adhesion (GO:0007158)2.40042219
75regulation of microtubule-based movement (GO:0060632)2.39251714
76indole-containing compound metabolic process (GO:0042430)2.37948411
77transmission of nerve impulse (GO:0019226)2.37728488
78negative regulation of mast cell activation (GO:0033004)2.37355206
79somite development (GO:0061053)2.36998961
80membrane depolarization during action potential (GO:0086010)2.36922789
81pancreas development (GO:0031016)2.36685161
82mechanosensory behavior (GO:0007638)2.35377868
83regulation of sarcomere organization (GO:0060297)2.34731753
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.34660321
85regulation of rhodopsin mediated signaling pathway (GO:0022400)2.34580103
86adaptation of signaling pathway (GO:0023058)2.33508763
87rRNA catabolic process (GO:0016075)2.32605503
88forebrain morphogenesis (GO:0048853)2.32324256
89S-adenosylmethionine metabolic process (GO:0046500)2.31704108
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.31008493
91cellular component assembly involved in morphogenesis (GO:0010927)2.30723015
92protein prenylation (GO:0018342)2.28716655
93prenylation (GO:0097354)2.28716655
94dendritic spine morphogenesis (GO:0060997)2.28712446
95regulation of hexokinase activity (GO:1903299)2.28158016
96regulation of glucokinase activity (GO:0033131)2.28158016
97detection of mechanical stimulus involved in sensory perception (GO:0050974)2.28025398
98mannosylation (GO:0097502)2.27817691
99preassembly of GPI anchor in ER membrane (GO:0016254)2.27463437
100serotonin metabolic process (GO:0042428)2.27256332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.88985670
2GBX2_23144817_ChIP-Seq_PC3_Human3.34766344
3VDR_22108803_ChIP-Seq_LS180_Human3.17209748
4EZH2_22144423_ChIP-Seq_EOC_Human3.07142044
5IGF1R_20145208_ChIP-Seq_DFB_Human2.90208853
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88165881
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86168047
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78334486
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76917720
10FUS_26573619_Chip-Seq_HEK293_Human2.51005070
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48054113
12TAF15_26573619_Chip-Seq_HEK293_Human2.38468177
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.30257005
14EWS_26573619_Chip-Seq_HEK293_Human2.28780006
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27964775
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16764109
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10675419
18* P300_19829295_ChIP-Seq_ESCs_Human2.02398370
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.98173144
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.86832089
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83067266
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79360092
23ER_23166858_ChIP-Seq_MCF-7_Human1.78422961
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76475588
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69075474
26SMAD4_21799915_ChIP-Seq_A2780_Human1.68375780
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67592860
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66013078
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64977593
30STAT3_23295773_ChIP-Seq_U87_Human1.63198059
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59607862
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56903802
33CBP_20019798_ChIP-Seq_JUKART_Human1.55111553
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55111553
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.53349480
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52665590
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51283554
38GATA1_22025678_ChIP-Seq_K562_Human1.50837410
39IRF1_19129219_ChIP-ChIP_H3396_Human1.50624587
40RNF2_27304074_Chip-Seq_NSC_Mouse1.47021472
41TCF4_23295773_ChIP-Seq_U87_Human1.46152889
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45866448
43AR_25329375_ChIP-Seq_VCAP_Human1.44277145
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42830969
45BCAT_22108803_ChIP-Seq_LS180_Human1.39856215
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.39591833
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39353618
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37682203
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37682203
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36958871
51TP53_22573176_ChIP-Seq_HFKS_Human1.36911135
52REST_21632747_ChIP-Seq_MESCs_Mouse1.36845768
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36807110
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.36233571
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35819916
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32007683
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31875064
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31404974
59MYC_18940864_ChIP-ChIP_HL60_Human1.28799995
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.27735911
61RUNX2_22187159_ChIP-Seq_PCA_Human1.25273695
62* EST1_17652178_ChIP-ChIP_JURKAT_Human1.25255125
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.22342205
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.22286118
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.21920983
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21587628
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.21077128
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20899366
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.19741321
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18282520
71AR_21572438_ChIP-Seq_LNCaP_Human1.15724066
72NANOG_19829295_ChIP-Seq_ESCs_Human1.15711565
73SOX2_19829295_ChIP-Seq_ESCs_Human1.15711565
74TCF4_22108803_ChIP-Seq_LS180_Human1.14170376
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14010414
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13582363
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11457375
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11238502
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10662758
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09311285
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08815615
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08639746
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.07201801
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06489910
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.06071819
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.05596263
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.05047969
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04970254
89P53_22387025_ChIP-Seq_ESCs_Mouse1.04819260
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03315837
91VDR_23849224_ChIP-Seq_CD4+_Human1.03039219
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02523408
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01879110
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.01634711
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01634711
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99523064
97ELK1_19687146_ChIP-ChIP_HELA_Human0.98054035
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97984584
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.97694579
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.95813337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.79812732
2MP0006292_abnormal_olfactory_placode2.65151970
3MP0003880_abnormal_central_pattern2.58291743
4MP0002102_abnormal_ear_morphology2.43156298
5MP0000569_abnormal_digit_pigmentation2.39364293
6MP0001968_abnormal_touch/_nociception2.31945099
7MP0009046_muscle_twitch2.19410583
8MP0003195_calcinosis2.19027980
9MP0003787_abnormal_imprinting2.18833967
10MP0005551_abnormal_eye_electrophysiolog2.16684392
11MP0006072_abnormal_retinal_apoptosis2.03139233
12MP0001984_abnormal_olfaction1.99499122
13MP0006276_abnormal_autonomic_nervous1.96608744
14MP0004147_increased_porphyrin_level1.96042676
15MP0002837_dystrophic_cardiac_calcinosis1.88179869
16MP0009745_abnormal_behavioral_response1.88035826
17MP0002736_abnormal_nociception_after1.84651855
18MP0004043_abnormal_pH_regulation1.84400097
19MP0002272_abnormal_nervous_system1.82235215
20MP0005646_abnormal_pituitary_gland1.79985133
21MP0001486_abnormal_startle_reflex1.77461434
22MP0004142_abnormal_muscle_tone1.76725945
23MP0000631_abnormal_neuroendocrine_gland1.75695182
24MP0004145_abnormal_muscle_electrophysio1.75449081
25MP0005645_abnormal_hypothalamus_physiol1.74244797
26MP0005253_abnormal_eye_physiology1.69936294
27MP0004133_heterotaxia1.66153877
28MP0004885_abnormal_endolymph1.63673963
29MP0003635_abnormal_synaptic_transmissio1.60831416
30MP0002735_abnormal_chemical_nociception1.60721868
31MP0002572_abnormal_emotion/affect_behav1.57233813
32MP0001501_abnormal_sleep_pattern1.55244481
33MP0005187_abnormal_penis_morphology1.51957510
34MP0000778_abnormal_nervous_system1.51112023
35MP0002063_abnormal_learning/memory/cond1.49351443
36MP0002638_abnormal_pupillary_reflex1.49321145
37MP0008995_early_reproductive_senescence1.46282776
38MP0003136_yellow_coat_color1.46007993
39MP0002064_seizures1.45472734
40MP0002876_abnormal_thyroid_physiology1.42637730
41MP0008872_abnormal_physiological_respon1.41935011
42MP0004924_abnormal_behavior1.39715055
43MP0005386_behavior/neurological_phenoty1.39715055
44MP0002653_abnormal_ependyma_morphology1.39508018
45MP0002938_white_spotting1.39402787
46MP0002557_abnormal_social/conspecific_i1.38099883
47MP0005499_abnormal_olfactory_system1.36486062
48MP0005394_taste/olfaction_phenotype1.36486062
49MP0003121_genomic_imprinting1.36434722
50MP0002928_abnormal_bile_duct1.34602607
51MP0003646_muscle_fatigue1.34027081
52MP0002067_abnormal_sensory_capabilities1.33311935
53MP0002160_abnormal_reproductive_system1.33048777
54MP0001188_hyperpigmentation1.30482004
55MP0008058_abnormal_DNA_repair1.28651669
56MP0003122_maternal_imprinting1.28384925
57MP0001986_abnormal_taste_sensitivity1.27219633
58MP0001485_abnormal_pinna_reflex1.22842898
59MP0002234_abnormal_pharynx_morphology1.22171085
60MP0001529_abnormal_vocalization1.21553074
61MP0008789_abnormal_olfactory_epithelium1.21220718
62MP0004859_abnormal_synaptic_plasticity1.15208113
63MP0005389_reproductive_system_phenotype1.13069276
64MP0002734_abnormal_mechanical_nocicepti1.10129325
65MP0002184_abnormal_innervation1.08693251
66MP0005084_abnormal_gallbladder_morpholo1.08469869
67MP0000372_irregular_coat_pigmentation1.07701300
68MP0000427_abnormal_hair_cycle1.06684367
69MP0003698_abnormal_male_reproductive1.05138744
70MP0004215_abnormal_myocardial_fiber1.05004863
71MP0001970_abnormal_pain_threshold1.04685328
72MP0005174_abnormal_tail_pigmentation1.02842613
73MP0002733_abnormal_thermal_nociception0.99639814
74MP0003890_abnormal_embryonic-extraembry0.97223386
75MP0002752_abnormal_somatic_nervous0.97072187
76MP0004742_abnormal_vestibular_system0.96484428
77MP0001293_anophthalmia0.95781577
78MP0003937_abnormal_limbs/digits/tail_de0.95680081
79MP0001929_abnormal_gametogenesis0.95667766
80MP0002882_abnormal_neuron_morphology0.95273691
81MP0000955_abnormal_spinal_cord0.95150712
82MP0008057_abnormal_DNA_replication0.94144670
83MP0002822_catalepsy0.92094618
84MP0002229_neurodegeneration0.92062120
85MP0005220_abnormal_exocrine_pancreas0.91023826
86MP0004270_analgesia0.87907145
87MP0005195_abnormal_posterior_eye0.86753667
88MP0002751_abnormal_autonomic_nervous0.85140673
89MP0001919_abnormal_reproductive_system0.84008860
90MP0003137_abnormal_impulse_conducting0.82933784
91MP0003119_abnormal_digestive_system0.82078693
92MP0003943_abnormal_hepatobiliary_system0.79800549
93MP0002210_abnormal_sex_determination0.79633207
94MP0001502_abnormal_circadian_rhythm0.78949305
95MP0005391_vision/eye_phenotype0.77646969
96MP0000653_abnormal_sex_gland0.76306787
97MP0005423_abnormal_somatic_nervous0.75986655
98MP0001440_abnormal_grooming_behavior0.74340307
99MP0002233_abnormal_nose_morphology0.73878759
100MP0001963_abnormal_hearing_physiology0.73372098

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.04957486
2Pancreatic fibrosis (HP:0100732)3.64614613
3Molar tooth sign on MRI (HP:0002419)3.55309575
4Abnormality of midbrain morphology (HP:0002418)3.55309575
5Progressive cerebellar ataxia (HP:0002073)3.35518122
6Nephronophthisis (HP:0000090)3.34034229
7Medial flaring of the eyebrow (HP:0010747)3.32786889
8True hermaphroditism (HP:0010459)3.29412517
9Congenital stationary night blindness (HP:0007642)3.27532747
10Hyperventilation (HP:0002883)3.17218012
11Type II lissencephaly (HP:0007260)3.10457366
12Abnormality of the renal cortex (HP:0011035)3.09428384
13Genetic anticipation (HP:0003743)3.09225461
14Abnormality of the renal medulla (HP:0100957)3.08695693
15Gaze-evoked nystagmus (HP:0000640)3.04439945
16Chronic hepatic failure (HP:0100626)2.93979900
17Gait imbalance (HP:0002141)2.89722443
18Renal cortical cysts (HP:0000803)2.85930024
19Congenital primary aphakia (HP:0007707)2.77904841
20Attenuation of retinal blood vessels (HP:0007843)2.75900920
21Broad-based gait (HP:0002136)2.74069700
22Volvulus (HP:0002580)2.67851865
23Cerebellar dysplasia (HP:0007033)2.67170296
24Febrile seizures (HP:0002373)2.63333186
25Nephrogenic diabetes insipidus (HP:0009806)2.51598136
26Genital tract atresia (HP:0001827)2.50693440
27Abnormal rod and cone electroretinograms (HP:0008323)2.49210390
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.47749158
29Abolished electroretinogram (ERG) (HP:0000550)2.47058021
30Vaginal atresia (HP:0000148)2.41618993
31Protruding tongue (HP:0010808)2.41063699
32Tubulointerstitial nephritis (HP:0001970)2.35798229
33Absent speech (HP:0001344)2.31156384
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30720933
35Constricted visual fields (HP:0001133)2.27472429
36Cystic liver disease (HP:0006706)2.22935767
37Fair hair (HP:0002286)2.22849487
38Poor coordination (HP:0002370)2.22353217
39Drooling (HP:0002307)2.17818983
40Abnormal drinking behavior (HP:0030082)2.16204853
41Polydipsia (HP:0001959)2.16204853
42Stomach cancer (HP:0012126)2.15882004
43Retinal dysplasia (HP:0007973)2.14951074
44Inability to walk (HP:0002540)2.13341914
45Lissencephaly (HP:0001339)2.12541635
46Hypothermia (HP:0002045)2.11846339
47Congenital hepatic fibrosis (HP:0002612)2.10075448
48Focal motor seizures (HP:0011153)2.07993455
49Bile duct proliferation (HP:0001408)2.06189128
50Abnormal biliary tract physiology (HP:0012439)2.06189128
51Methylmalonic acidemia (HP:0002912)2.05061393
52Hemiparesis (HP:0001269)2.03881892
53Optic nerve hypoplasia (HP:0000609)2.01062087
54Atonic seizures (HP:0010819)1.99120539
55Focal seizures (HP:0007359)1.99029936
56Tubular atrophy (HP:0000092)1.98975362
57Progressive inability to walk (HP:0002505)1.98770068
58Dialeptic seizures (HP:0011146)1.97491591
59Postaxial hand polydactyly (HP:0001162)1.96909343
60Excessive salivation (HP:0003781)1.94710606
61Large for gestational age (HP:0001520)1.91671520
62Pendular nystagmus (HP:0012043)1.90393407
63Abnormal ciliary motility (HP:0012262)1.89651478
64Pachygyria (HP:0001302)1.88838714
65Short tibia (HP:0005736)1.88803893
66Hyperglycinemia (HP:0002154)1.88004643
67Widely spaced teeth (HP:0000687)1.86901333
68Abnormal respiratory epithelium morphology (HP:0012253)1.86592311
69Abnormal respiratory motile cilium morphology (HP:0005938)1.86592311
70Muscle hypertrophy of the lower extremities (HP:0008968)1.86461150
71Clumsiness (HP:0002312)1.85137403
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82140512
73Postaxial foot polydactyly (HP:0001830)1.81055212
74Severe muscular hypotonia (HP:0006829)1.80770480
75Anencephaly (HP:0002323)1.80647780
76Specific learning disability (HP:0001328)1.79938059
77Absent/shortened dynein arms (HP:0200106)1.79033120
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.79033120
79Hypoplastic iliac wings (HP:0002866)1.78359166
80Aplasia/Hypoplasia of the tongue (HP:0010295)1.78216370
81Birth length less than 3rd percentile (HP:0003561)1.77862488
82Limb dystonia (HP:0002451)1.77176710
83Hypoplasia of the pons (HP:0012110)1.76830455
84Keratoconus (HP:0000563)1.76394206
85Increased corneal curvature (HP:0100692)1.76394206
86Epileptic encephalopathy (HP:0200134)1.76106505
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75151658
88Abnormality of the pons (HP:0007361)1.73874613
89Sclerocornea (HP:0000647)1.71935331
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.71826728
91Intestinal atresia (HP:0011100)1.70914440
92Bony spicule pigmentary retinopathy (HP:0007737)1.70391578
93Patellar aplasia (HP:0006443)1.70121279
94Abnormality of macular pigmentation (HP:0008002)1.69313763
95Short foot (HP:0001773)1.68713700
96Acute lymphatic leukemia (HP:0006721)1.68684408
97Furrowed tongue (HP:0000221)1.68364899
98Generalized hypopigmentation of hair (HP:0011358)1.66862172
99Highly arched eyebrow (HP:0002553)1.66015866
100Decreased central vision (HP:0007663)1.64261769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.01261716
2WNK33.37869088
3MAP3K42.90874026
4BMPR1B2.57793427
5CASK2.57529791
6MAP4K22.33484781
7ZAK2.15674706
8MARK12.05438048
9ACVR1B2.01749754
10ADRBK22.01720246
11PINK11.98136480
12INSRR1.96254347
13MAPK131.90994741
14NUAK11.81760091
15MAP2K71.77133305
16TAOK31.67402498
17TRPM71.63598358
18MKNK21.62941480
19GRK11.60189804
20EPHA41.43211534
21WNK41.39315354
22TNIK1.36681612
23TRIM281.32235981
24MKNK11.26692544
25PNCK1.24475063
26CAMKK21.24339634
27BCR1.22919156
28OXSR11.22713658
29PLK21.16815711
30DAPK21.16469207
31BRSK21.11377041
32PAK31.10718835
33CDK191.09728036
34NTRK21.06274268
35CSNK1G21.05469791
36FGFR21.04221338
37TGFBR11.03674535
38ERBB31.03376111
39STK38L1.00507627
40NTRK30.99671073
41CSNK1G10.98539181
42PRKCG0.95942576
43TLK10.95901188
44CSNK1A1L0.95814623
45DYRK20.93490720
46CSNK1G30.92277761
47KIT0.90108291
48AKT30.83317026
49STK390.82888125
50PRKCE0.80499097
51CDK30.77520957
52MAP2K40.77159170
53TXK0.77093418
54PLK40.76557354
55IRAK10.74629721
56FLT30.74440166
57SGK20.73712523
58SRPK10.73340951
59EPHA30.72701256
60TEC0.69282480
61ADRBK10.67292372
62OBSCN0.66792974
63EIF2AK30.66412821
64PASK0.66208331
65PHKG20.66076952
66PHKG10.66076952
67PKN10.61491787
68VRK10.61005935
69CAMK2A0.60441210
70RPS6KA50.59876370
71PLK30.59780534
72MARK30.59761486
73SIK20.57885890
74CSNK1D0.57203308
75SGK4940.57086230
76SGK2230.57086230
77MUSK0.55631602
78MAPK150.53095731
79LATS10.52453380
80BRD40.49715234
81DYRK1A0.49655225
82WEE10.47711263
83PIK3CA0.47603067
84ATM0.46487865
85NLK0.45337663
86CSNK1A10.44880023
87MAPKAPK50.44547725
88ATR0.43498180
89PRKACA0.42619644
90STK110.41673402
91MATK0.40559206
92CAMKK10.38017557
93PRKACB0.38011092
94MAP2K60.37575257
95GRK50.37351407
96BCKDK0.36902116
97PRKCZ0.36865084
98PRKG10.35750712
99CAMK10.35734283
100GRK70.35591178

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.12816781
2Nicotine addiction_Homo sapiens_hsa050333.07718536
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.92625375
4Butanoate metabolism_Homo sapiens_hsa006502.43695014
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39957202
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35950407
7Selenocompound metabolism_Homo sapiens_hsa004502.21037236
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.19114987
9Fanconi anemia pathway_Homo sapiens_hsa034602.16634648
10Taste transduction_Homo sapiens_hsa047422.10272728
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06130202
12Nitrogen metabolism_Homo sapiens_hsa009102.04193170
13Linoleic acid metabolism_Homo sapiens_hsa005912.03086244
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94059573
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93308855
16Ether lipid metabolism_Homo sapiens_hsa005651.86019589
17RNA polymerase_Homo sapiens_hsa030201.80618864
18Morphine addiction_Homo sapiens_hsa050321.75133990
19GABAergic synapse_Homo sapiens_hsa047271.62236889
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59444482
21Homologous recombination_Homo sapiens_hsa034401.57863280
22RNA degradation_Homo sapiens_hsa030181.54976469
23Olfactory transduction_Homo sapiens_hsa047401.54502472
24Protein export_Homo sapiens_hsa030601.53945676
25Circadian entrainment_Homo sapiens_hsa047131.52243313
26Basal transcription factors_Homo sapiens_hsa030221.51486476
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45656297
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43081273
29Non-homologous end-joining_Homo sapiens_hsa034501.38213243
30Circadian rhythm_Homo sapiens_hsa047101.36999801
31Propanoate metabolism_Homo sapiens_hsa006401.36166093
32ABC transporters_Homo sapiens_hsa020101.36095035
33Glutamatergic synapse_Homo sapiens_hsa047241.33354696
34Insulin secretion_Homo sapiens_hsa049111.32795138
35Serotonergic synapse_Homo sapiens_hsa047261.27607454
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25730778
37Oxidative phosphorylation_Homo sapiens_hsa001901.22869780
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21439461
39Peroxisome_Homo sapiens_hsa041461.18787348
40Regulation of autophagy_Homo sapiens_hsa041401.17664307
41Dopaminergic synapse_Homo sapiens_hsa047281.16484602
42Tryptophan metabolism_Homo sapiens_hsa003801.12211228
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.01020094
44Salivary secretion_Homo sapiens_hsa049700.99257385
45Caffeine metabolism_Homo sapiens_hsa002320.96239725
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93348096
47Cocaine addiction_Homo sapiens_hsa050300.93002588
48Amphetamine addiction_Homo sapiens_hsa050310.92968224
49Parkinsons disease_Homo sapiens_hsa050120.89082184
50Long-term depression_Homo sapiens_hsa047300.86989075
51Dorso-ventral axis formation_Homo sapiens_hsa043200.86219397
52Calcium signaling pathway_Homo sapiens_hsa040200.85069541
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.76353793
54One carbon pool by folate_Homo sapiens_hsa006700.74754069
55beta-Alanine metabolism_Homo sapiens_hsa004100.71657491
56Ovarian steroidogenesis_Homo sapiens_hsa049130.69846469
57Cardiac muscle contraction_Homo sapiens_hsa042600.67827770
58Collecting duct acid secretion_Homo sapiens_hsa049660.67519793
59Purine metabolism_Homo sapiens_hsa002300.67436623
60Huntingtons disease_Homo sapiens_hsa050160.66964202
61Chemical carcinogenesis_Homo sapiens_hsa052040.60734792
62Mineral absorption_Homo sapiens_hsa049780.60489334
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59998153
64Lysine degradation_Homo sapiens_hsa003100.58898927
65Cholinergic synapse_Homo sapiens_hsa047250.58789607
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58710288
67Hedgehog signaling pathway_Homo sapiens_hsa043400.58295581
68Arachidonic acid metabolism_Homo sapiens_hsa005900.57820572
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57198590
70cAMP signaling pathway_Homo sapiens_hsa040240.56664665
71Glycerolipid metabolism_Homo sapiens_hsa005610.56647096
72Oxytocin signaling pathway_Homo sapiens_hsa049210.53790245
73RNA transport_Homo sapiens_hsa030130.53368291
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52577566
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51746177
76Steroid biosynthesis_Homo sapiens_hsa001000.48802721
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48602974
78Type I diabetes mellitus_Homo sapiens_hsa049400.48452081
79Renin secretion_Homo sapiens_hsa049240.47950475
80Retinol metabolism_Homo sapiens_hsa008300.47642094
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.44593532
82Type II diabetes mellitus_Homo sapiens_hsa049300.44508737
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42465017
84Primary immunodeficiency_Homo sapiens_hsa053400.41937169
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.40588466
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40584271
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40547102
88Metabolic pathways_Homo sapiens_hsa011000.39268952
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38424075
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38122592
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36544200
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35085872
93Alzheimers disease_Homo sapiens_hsa050100.34428102
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33981698
95Oocyte meiosis_Homo sapiens_hsa041140.32329332
96Gastric acid secretion_Homo sapiens_hsa049710.31637362
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.31221480
98mRNA surveillance pathway_Homo sapiens_hsa030150.31116598
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29675241
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29509003

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