ZNF527

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.56187289
2fucose catabolic process (GO:0019317)4.44184729
3L-fucose metabolic process (GO:0042354)4.44184729
4L-fucose catabolic process (GO:0042355)4.44184729
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.07026746
6response to pheromone (GO:0019236)3.83364610
7tryptophan catabolic process (GO:0006569)3.77717145
8indole-containing compound catabolic process (GO:0042436)3.77717145
9indolalkylamine catabolic process (GO:0046218)3.77717145
10indolalkylamine metabolic process (GO:0006586)3.77208384
11DNA deamination (GO:0045006)3.73214382
12kynurenine metabolic process (GO:0070189)3.71268286
13gamma-aminobutyric acid transport (GO:0015812)3.68119902
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.57026618
15water-soluble vitamin biosynthetic process (GO:0042364)3.44046670
16pyrimidine nucleobase catabolic process (GO:0006208)3.42204350
17protein polyglutamylation (GO:0018095)3.40751406
18sulfation (GO:0051923)3.35725735
19regulation of cilium movement (GO:0003352)3.33119964
20tryptophan metabolic process (GO:0006568)3.26225991
21negative regulation of mast cell activation (GO:0033004)3.25257845
22neuronal action potential (GO:0019228)3.22217597
23neural tube formation (GO:0001841)3.18175245
24nonmotile primary cilium assembly (GO:0035058)3.16874499
25detection of light stimulus involved in sensory perception (GO:0050962)3.14719518
26detection of light stimulus involved in visual perception (GO:0050908)3.14719518
27platelet dense granule organization (GO:0060155)3.08266678
28indole-containing compound metabolic process (GO:0042430)3.07551840
29cellular ketone body metabolic process (GO:0046950)3.04057278
30cornea development in camera-type eye (GO:0061303)3.03778023
31kidney morphogenesis (GO:0060993)3.03257700
32epithelial cilium movement (GO:0003351)3.01036860
33negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91474576
34axoneme assembly (GO:0035082)2.90219737
35somite development (GO:0061053)2.90104856
36transmission of nerve impulse (GO:0019226)2.89939740
37reflex (GO:0060004)2.89453775
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87326688
39nucleobase catabolic process (GO:0046113)2.86891309
40serotonin metabolic process (GO:0042428)2.86291271
41cilium morphogenesis (GO:0060271)2.85861234
42ketone body metabolic process (GO:1902224)2.83448502
43primary amino compound metabolic process (GO:1901160)2.82232532
44regulation of action potential (GO:0098900)2.79996167
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78962567
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.78962567
47NADH dehydrogenase complex assembly (GO:0010257)2.78962567
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78687381
49piRNA metabolic process (GO:0034587)2.78179376
50photoreceptor cell development (GO:0042461)2.75464763
51protein-cofactor linkage (GO:0018065)2.74780209
52preassembly of GPI anchor in ER membrane (GO:0016254)2.70542552
53behavioral response to ethanol (GO:0048149)2.70384229
54regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70231923
55cell proliferation in forebrain (GO:0021846)2.67048093
56negative regulation of telomere maintenance (GO:0032205)2.64255563
57spinal cord motor neuron differentiation (GO:0021522)2.63787565
58photoreceptor cell maintenance (GO:0045494)2.63534382
59protein complex biogenesis (GO:0070271)2.62030343
60protein K11-linked deubiquitination (GO:0035871)2.61571338
61rhodopsin mediated signaling pathway (GO:0016056)2.60173983
62retinal cone cell development (GO:0046549)2.59868813
63reciprocal DNA recombination (GO:0035825)2.59596274
64reciprocal meiotic recombination (GO:0007131)2.59596274
65recombinational repair (GO:0000725)2.59124749
66startle response (GO:0001964)2.58897931
67presynaptic membrane assembly (GO:0097105)2.58284550
68double-strand break repair via homologous recombination (GO:0000724)2.58097622
69cAMP catabolic process (GO:0006198)2.57008898
70cilium organization (GO:0044782)2.56867581
71dopamine transport (GO:0015872)2.55787749
72cellular response to ATP (GO:0071318)2.55449055
73negative regulation of systemic arterial blood pressure (GO:0003085)2.54909532
74membrane depolarization during action potential (GO:0086010)2.54328846
75negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52128088
76otic vesicle formation (GO:0030916)2.51879439
77regulation of glucokinase activity (GO:0033131)2.51581696
78regulation of hexokinase activity (GO:1903299)2.51581696
79cilium assembly (GO:0042384)2.50905992
80protein localization to cilium (GO:0061512)2.50212452
81cellular biogenic amine catabolic process (GO:0042402)2.49591307
82amine catabolic process (GO:0009310)2.49591307
83ubiquinone biosynthetic process (GO:0006744)2.48898496
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.48881680
85eye photoreceptor cell development (GO:0042462)2.48806785
86regulation of hippo signaling (GO:0035330)2.48744482
87tachykinin receptor signaling pathway (GO:0007217)2.47052000
88synaptic transmission, cholinergic (GO:0007271)2.46712018
89replication fork processing (GO:0031297)2.45568573
90cilium movement (GO:0003341)2.45402913
91mitochondrial respiratory chain complex assembly (GO:0033108)2.43699087
92regulation of mesoderm development (GO:2000380)2.43489244
93adaptation of signaling pathway (GO:0023058)2.43311757
94negative regulation of transcription regulatory region DNA binding (GO:2000678)2.42586387
95positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42533109
96ubiquinone metabolic process (GO:0006743)2.41292869
97embryonic epithelial tube formation (GO:0001838)2.38684956
98action potential (GO:0001508)2.38611905
99positive regulation of oligodendrocyte differentiation (GO:0048714)2.38220186
100regulation of microtubule-based movement (GO:0060632)2.36903376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.81263273
2GBX2_23144817_ChIP-Seq_PC3_Human3.30068867
3EZH2_22144423_ChIP-Seq_EOC_Human3.20508889
4VDR_22108803_ChIP-Seq_LS180_Human2.96063482
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92622243
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90514901
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73727546
8IGF1R_20145208_ChIP-Seq_DFB_Human2.46732342
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37479403
10FUS_26573619_Chip-Seq_HEK293_Human2.28985604
11EWS_26573619_Chip-Seq_HEK293_Human2.28498036
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26652561
13TAF15_26573619_Chip-Seq_HEK293_Human2.16538447
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15281009
15P300_19829295_ChIP-Seq_ESCs_Human2.07069072
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.06868976
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.04749907
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90411408
19ER_23166858_ChIP-Seq_MCF-7_Human1.83743537
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80817771
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78134422
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72503176
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.66293849
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66122359
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65869715
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.63567705
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63462263
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62786224
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62726252
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62663323
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.61125938
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60992021
33STAT3_23295773_ChIP-Seq_U87_Human1.59414438
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59326925
35IRF1_19129219_ChIP-ChIP_H3396_Human1.56724420
36SMAD4_21799915_ChIP-Seq_A2780_Human1.56208258
37BCAT_22108803_ChIP-Seq_LS180_Human1.54275633
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54087707
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49056711
40CBP_20019798_ChIP-Seq_JUKART_Human1.49056711
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48473252
42AR_25329375_ChIP-Seq_VCAP_Human1.46653275
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45445704
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44856146
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44655193
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44655193
47TCF4_23295773_ChIP-Seq_U87_Human1.44593783
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44520500
49REST_21632747_ChIP-Seq_MESCs_Mouse1.44369218
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43372557
51TP53_22573176_ChIP-Seq_HFKS_Human1.41008019
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.36227183
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35950851
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34298348
55MYC_18940864_ChIP-ChIP_HL60_Human1.33937878
56RNF2_27304074_Chip-Seq_NSC_Mouse1.33663037
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28267402
58AR_21572438_ChIP-Seq_LNCaP_Human1.27204950
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26693680
60SOX2_19829295_ChIP-Seq_ESCs_Human1.25453003
61NANOG_19829295_ChIP-Seq_ESCs_Human1.25453003
62RUNX2_22187159_ChIP-Seq_PCA_Human1.24313857
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.24040761
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23113536
65* TCF4_22108803_ChIP-Seq_LS180_Human1.22493862
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22309350
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22305557
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.21964306
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20817635
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.20278712
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.19107405
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19107405
73* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17422879
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.16399474
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.12982311
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12765877
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.11808529
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.11575726
79NCOR_22424771_ChIP-Seq_293T_Human1.11080484
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10989615
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10446609
82* SMAD4_21741376_ChIP-Seq_EPCs_Human1.10115828
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.10059733
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09951760
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08521310
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07661054
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07350408
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07091852
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06398091
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.04961910
91P53_22387025_ChIP-Seq_ESCs_Mouse1.04892430
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03508342
93AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01967975
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.01620515
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01514920
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01297670
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99443033
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97747112
99AR_20517297_ChIP-Seq_VCAP_Human0.96894877
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96800373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.76644896
2MP0002102_abnormal_ear_morphology2.66446881
3MP0003195_calcinosis2.60035622
4MP0003646_muscle_fatigue2.55096781
5MP0008877_abnormal_DNA_methylation2.52966656
6MP0002837_dystrophic_cardiac_calcinosis2.52248018
7MP0003136_yellow_coat_color2.51907609
8MP0005551_abnormal_eye_electrophysiolog2.44439163
9MP0001968_abnormal_touch/_nociception2.34652628
10MP0004885_abnormal_endolymph2.22170014
11MP0000569_abnormal_digit_pigmentation2.16812399
12MP0002638_abnormal_pupillary_reflex2.06606673
13MP0009046_muscle_twitch2.06117333
14MP0002736_abnormal_nociception_after2.04548848
15MP0003787_abnormal_imprinting2.00005939
16MP0006072_abnormal_retinal_apoptosis1.99546490
17MP0000372_irregular_coat_pigmentation1.97912518
18MP0004142_abnormal_muscle_tone1.97871431
19MP0009745_abnormal_behavioral_response1.96509798
20MP0002272_abnormal_nervous_system1.82758298
21MP0001986_abnormal_taste_sensitivity1.80928104
22MP0005646_abnormal_pituitary_gland1.79205703
23MP0008872_abnormal_physiological_respon1.75698922
24MP0001485_abnormal_pinna_reflex1.70126809
25MP0005253_abnormal_eye_physiology1.67263742
26MP0002735_abnormal_chemical_nociception1.66900457
27MP0004145_abnormal_muscle_electrophysio1.66171632
28MP0006276_abnormal_autonomic_nervous1.64895005
29MP0000631_abnormal_neuroendocrine_gland1.62679588
30MP0002653_abnormal_ependyma_morphology1.57300071
31MP0002876_abnormal_thyroid_physiology1.54896376
32MP0005174_abnormal_tail_pigmentation1.54741023
33MP0003880_abnormal_central_pattern1.54054302
34MP0008875_abnormal_xenobiotic_pharmacok1.52756790
35MP0004133_heterotaxia1.50983295
36MP0005645_abnormal_hypothalamus_physiol1.50149243
37MP0001501_abnormal_sleep_pattern1.47484679
38MP0001486_abnormal_startle_reflex1.47483799
39MP0002938_white_spotting1.46677499
40MP0000427_abnormal_hair_cycle1.42983290
41MP0004742_abnormal_vestibular_system1.39380939
42MP0001984_abnormal_olfaction1.38371774
43MP0002572_abnormal_emotion/affect_behav1.37731601
44MP0002064_seizures1.35801266
45MP0001970_abnormal_pain_threshold1.34537216
46MP0002160_abnormal_reproductive_system1.33790597
47MP0005084_abnormal_gallbladder_morpholo1.31987491
48MP0002733_abnormal_thermal_nociception1.31001755
49MP0002557_abnormal_social/conspecific_i1.29018769
50MP0002138_abnormal_hepatobiliary_system1.27862157
51MP0001529_abnormal_vocalization1.27718550
52MP0004147_increased_porphyrin_level1.24298845
53MP0000778_abnormal_nervous_system1.23110536
54MP0003635_abnormal_synaptic_transmissio1.22714927
55MP0005389_reproductive_system_phenotype1.22375181
56MP0002234_abnormal_pharynx_morphology1.21050720
57MP0002067_abnormal_sensory_capabilities1.20838023
58MP0002928_abnormal_bile_duct1.20445633
59MP0002734_abnormal_mechanical_nocicepti1.20301530
60MP0005386_behavior/neurological_phenoty1.16954179
61MP0004924_abnormal_behavior1.16954179
62MP0004043_abnormal_pH_regulation1.15789141
63MP0002063_abnormal_learning/memory/cond1.14469200
64MP0002095_abnormal_skin_pigmentation1.12919515
65MP0010386_abnormal_urinary_bladder1.11983966
66MP0005423_abnormal_somatic_nervous1.10866547
67MP0005195_abnormal_posterior_eye1.09677765
68MP0002277_abnormal_respiratory_mucosa1.07641181
69MP0003011_delayed_dark_adaptation1.06444665
70MP0002163_abnormal_gland_morphology1.04962162
71MP0002752_abnormal_somatic_nervous0.99297003
72MP0003718_maternal_effect0.96010515
73MP0000026_abnormal_inner_ear0.95532189
74MP0004215_abnormal_myocardial_fiber0.95110032
75MP0003283_abnormal_digestive_organ0.94733797
76MP0002751_abnormal_autonomic_nervous0.94661509
77MP0008058_abnormal_DNA_repair0.90357740
78MP0000230_abnormal_systemic_arterial0.87863389
79MP0002184_abnormal_innervation0.87431252
80MP0001963_abnormal_hearing_physiology0.87323969
81MP0001919_abnormal_reproductive_system0.86873609
82MP0005075_abnormal_melanosome_morpholog0.86798599
83MP0005379_endocrine/exocrine_gland_phen0.85519212
84MP0001905_abnormal_dopamine_level0.85431446
85MP0000049_abnormal_middle_ear0.82586991
86MP0000383_abnormal_hair_follicle0.82480926
87MP0001324_abnormal_eye_pigmentation0.82462083
88MP0003890_abnormal_embryonic-extraembry0.82107735
89MP0000955_abnormal_spinal_cord0.82103255
90MP0002229_neurodegeneration0.81420278
91MP0005171_absent_coat_pigmentation0.80840826
92MP0003119_abnormal_digestive_system0.80818575
93MP0003937_abnormal_limbs/digits/tail_de0.80466052
94MP0008775_abnormal_heart_ventricle0.79049257
95MP0003137_abnormal_impulse_conducting0.77939967
96MP0005410_abnormal_fertilization0.77688722
97MP0003121_genomic_imprinting0.76040013
98MP0003698_abnormal_male_reproductive0.75385237
99MP0005187_abnormal_penis_morphology0.73376436
100MP0001293_anophthalmia0.73141356

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.80370182
2Pancreatic fibrosis (HP:0100732)4.33753198
3Molar tooth sign on MRI (HP:0002419)4.25753716
4Abnormality of midbrain morphology (HP:0002418)4.25753716
5Congenital stationary night blindness (HP:0007642)4.24620328
6True hermaphroditism (HP:0010459)4.21935957
7Nephronophthisis (HP:0000090)3.86608292
8Abnormality of the renal cortex (HP:0011035)3.38449580
9Abnormality of the renal medulla (HP:0100957)3.36520478
10Hyperventilation (HP:0002883)3.13345390
11Pendular nystagmus (HP:0012043)3.06690849
12Medial flaring of the eyebrow (HP:0010747)2.98280990
13Cystic liver disease (HP:0006706)2.91970722
14Abolished electroretinogram (ERG) (HP:0000550)2.87670682
15Attenuation of retinal blood vessels (HP:0007843)2.87450030
16Progressive cerebellar ataxia (HP:0002073)2.77720840
17Chronic hepatic failure (HP:0100626)2.77593039
18Hyperalaninemia (HP:0003348)2.73810715
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73810715
20Abnormality of alanine metabolism (HP:0010916)2.73810715
21Genetic anticipation (HP:0003743)2.65417336
22Type II lissencephaly (HP:0007260)2.65270097
23Inability to walk (HP:0002540)2.62406100
24Tubular atrophy (HP:0000092)2.60387083
25Gaze-evoked nystagmus (HP:0000640)2.60219900
26Progressive inability to walk (HP:0002505)2.57244341
27Abnormal rod and cone electroretinograms (HP:0008323)2.55952005
28Absent/shortened dynein arms (HP:0200106)2.54614059
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.54614059
30Renal cortical cysts (HP:0000803)2.51742898
31Decreased central vision (HP:0007663)2.50807752
32Gait imbalance (HP:0002141)2.49019871
33Furrowed tongue (HP:0000221)2.45965530
34Abnormal drinking behavior (HP:0030082)2.44155669
35Polydipsia (HP:0001959)2.44155669
36Sclerocornea (HP:0000647)2.41963767
37Keratoconus (HP:0000563)2.41080323
38Increased corneal curvature (HP:0100692)2.41080323
39Congenital primary aphakia (HP:0007707)2.37507031
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.29186304
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.26988151
42Congenital hepatic fibrosis (HP:0002612)2.25506300
43Anencephaly (HP:0002323)2.23863256
44Abnormal biliary tract physiology (HP:0012439)2.23443538
45Bile duct proliferation (HP:0001408)2.23443538
46Lissencephaly (HP:0001339)2.22717899
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20441213
48Broad-based gait (HP:0002136)2.19502987
49Chorioretinal atrophy (HP:0000533)2.19491734
50Bony spicule pigmentary retinopathy (HP:0007737)2.18078956
51Nephrogenic diabetes insipidus (HP:0009806)2.17781307
52Large for gestational age (HP:0001520)2.17108894
53Congenital, generalized hypertrichosis (HP:0004540)2.16553623
54Abnormal respiratory motile cilium morphology (HP:0005938)2.13312993
55Abnormal respiratory epithelium morphology (HP:0012253)2.13312993
56Genital tract atresia (HP:0001827)2.13040398
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09342606
58Male pseudohermaphroditism (HP:0000037)2.09115298
59Vaginal atresia (HP:0000148)2.07543925
60Methylmalonic acidemia (HP:0002912)2.07199893
61Hemiparesis (HP:0001269)2.06849726
62Optic nerve hypoplasia (HP:0000609)2.06749707
63Febrile seizures (HP:0002373)2.05587434
64Congenital sensorineural hearing impairment (HP:0008527)2.03849617
65Polyuria (HP:0000103)2.03140942
66Aplasia/Hypoplasia of the patella (HP:0006498)2.02001277
67Patellar aplasia (HP:0006443)2.01010163
68Stomach cancer (HP:0012126)2.00885453
69Protruding tongue (HP:0010808)1.96741731
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92497420
71Abnormal ciliary motility (HP:0012262)1.88606613
72Concave nail (HP:0001598)1.86442230
73Methylmalonic aciduria (HP:0012120)1.85873519
74Focal motor seizures (HP:0011153)1.85644161
75Pachygyria (HP:0001302)1.84214366
76Decreased circulating renin level (HP:0003351)1.82871072
77Postaxial foot polydactyly (HP:0001830)1.82533952
78Hypothermia (HP:0002045)1.82214304
793-Methylglutaconic aciduria (HP:0003535)1.79545966
80Cerebellar dysplasia (HP:0007033)1.78554924
81Tachypnea (HP:0002789)1.77102033
82Small hand (HP:0200055)1.76776321
83Poor coordination (HP:0002370)1.75042136
84Increased CSF lactate (HP:0002490)1.73728915
85Abnormality of the labia minora (HP:0012880)1.72942197
86Acute necrotizing encephalopathy (HP:0006965)1.72241233
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.72205151
88Clumsiness (HP:0002312)1.72183040
89Fair hair (HP:0002286)1.71960029
90Astigmatism (HP:0000483)1.69187109
91Focal seizures (HP:0007359)1.67427710
92Mitochondrial inheritance (HP:0001427)1.66795387
93Ketoacidosis (HP:0001993)1.66138399
94Postaxial hand polydactyly (HP:0001162)1.64403419
95Intestinal atresia (HP:0011100)1.64291156
96Severe muscular hypotonia (HP:0006829)1.64205485
97Progressive macrocephaly (HP:0004481)1.62856488
98Optic disc pallor (HP:0000543)1.62629848
99Birth length less than 3rd percentile (HP:0003561)1.62246794
100Short tibia (HP:0005736)1.62237056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.07012338
2ADRBK23.19639486
3BMPR1B3.08688632
4TAOK32.80337842
5MAP4K22.68972035
6ACVR1B2.47010273
7GRK12.46166592
8CASK2.37335460
9MAPK132.29518761
10ZAK2.27490901
11TLK12.26336288
12WNK32.20304514
13NUAK12.18575225
14PINK11.98274693
15MARK11.81244947
16WNK41.75595612
17INSRR1.73194122
18MAP3K41.71831606
19PNCK1.67531175
20OXSR11.29435821
21TXK1.26443344
22DAPK21.24965423
23STK391.21961109
24ADRBK11.19137217
25DYRK21.16650761
26MKNK21.11690703
27TNIK1.08911120
28CAMKK21.06816013
29PAK31.04789073
30TGFBR11.02060828
31PRKCG1.01839735
32PHKG10.95643826
33PHKG20.95643826
34TIE10.94862533
35PLK20.94561670
36MAP2K70.92615513
37PRKCE0.90947944
38TRIM280.85581142
39NEK10.85362283
40CSNK1G20.84594951
41BRSK20.83656015
42FGFR20.81839156
43PLK40.80148058
44STK38L0.78640895
45MAPK150.77981142
46PIK3CA0.77958860
47VRK10.77244688
48NTRK20.76797798
49NTRK30.74699120
50MUSK0.74239188
51NEK20.74046275
52TEC0.73842265
53PKN10.73623079
54STK160.72990086
55CSNK1G10.71309283
56EPHA30.69511172
57BCKDK0.68253482
58BCR0.67409518
59OBSCN0.67368067
60MAP2K60.67135650
61IKBKB0.65649453
62CSNK1G30.64866787
63WEE10.61545733
64CAMK2A0.60562022
65PRKCQ0.59985342
66SIK20.58230009
67PTK2B0.57345231
68GRK70.54874209
69MAPKAPK50.53641826
70CSNK1A1L0.52258220
71MAPKAPK30.51351997
72RPS6KA50.49710740
73ERBB30.48545503
74CDK30.48054484
75STK30.47871654
76PRKACA0.47786175
77KIT0.46614230
78GRK50.44333442
79EPHA40.44297027
80PLK30.43712518
81ITK0.42439851
82CSNK1A10.42177758
83STK110.41861519
84PRKCZ0.40658960
85CHUK0.40310094
86CSNK1D0.39870644
87MARK30.38704723
88TNK20.38213057
89CAMK10.36576212
90MKNK10.35801426
91ERBB20.34080437
92SGK20.32394447
93IRAK10.31934604
94PRKG10.31831260
95PRKCA0.31598229
96CHEK20.30917728
97MAP2K40.30854593
98PRKCI0.30090905
99FLT30.29084486
100TAF10.28989427

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.94606973
2Nitrogen metabolism_Homo sapiens_hsa009102.45843065
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.44858308
4Nicotine addiction_Homo sapiens_hsa050332.41142663
5Linoleic acid metabolism_Homo sapiens_hsa005912.36326841
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33104127
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29184557
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22880034
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17591965
10Butanoate metabolism_Homo sapiens_hsa006502.16247047
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15800063
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12957876
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.11372031
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08084061
15Selenocompound metabolism_Homo sapiens_hsa004501.98351855
16Homologous recombination_Homo sapiens_hsa034401.97749242
17Oxidative phosphorylation_Homo sapiens_hsa001901.89370254
18RNA polymerase_Homo sapiens_hsa030201.88263892
19Tryptophan metabolism_Homo sapiens_hsa003801.79168995
20Protein export_Homo sapiens_hsa030601.74087446
21Fanconi anemia pathway_Homo sapiens_hsa034601.66239209
22Taste transduction_Homo sapiens_hsa047421.62336500
23Ether lipid metabolism_Homo sapiens_hsa005651.59319068
24Morphine addiction_Homo sapiens_hsa050321.52296439
25Basal transcription factors_Homo sapiens_hsa030221.51722854
26Caffeine metabolism_Homo sapiens_hsa002321.51078138
27Parkinsons disease_Homo sapiens_hsa050121.43625750
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.43336222
29Olfactory transduction_Homo sapiens_hsa047401.41808921
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38083278
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30986233
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30565589
33Propanoate metabolism_Homo sapiens_hsa006401.26061562
34RNA degradation_Homo sapiens_hsa030181.20716351
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.20527706
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12012251
37Chemical carcinogenesis_Homo sapiens_hsa052041.10890484
38GABAergic synapse_Homo sapiens_hsa047271.08945366
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06790696
40Circadian entrainment_Homo sapiens_hsa047131.06487934
41Insulin secretion_Homo sapiens_hsa049111.04943833
42Glutamatergic synapse_Homo sapiens_hsa047241.03049842
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.02783803
44Serotonergic synapse_Homo sapiens_hsa047261.01186279
45Cardiac muscle contraction_Homo sapiens_hsa042601.00558851
46ABC transporters_Homo sapiens_hsa020101.00018651
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99875532
48Huntingtons disease_Homo sapiens_hsa050160.95762226
49Retinol metabolism_Homo sapiens_hsa008300.95238698
50Asthma_Homo sapiens_hsa053100.94038286
51One carbon pool by folate_Homo sapiens_hsa006700.93164017
52Peroxisome_Homo sapiens_hsa041460.91912021
53Alzheimers disease_Homo sapiens_hsa050100.88307515
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85896705
55Arachidonic acid metabolism_Homo sapiens_hsa005900.82112024
56Non-homologous end-joining_Homo sapiens_hsa034500.80802775
57Dorso-ventral axis formation_Homo sapiens_hsa043200.80197293
58Calcium signaling pathway_Homo sapiens_hsa040200.77262374
59Regulation of autophagy_Homo sapiens_hsa041400.76649237
60Glycerolipid metabolism_Homo sapiens_hsa005610.75895108
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74381942
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74020492
63Ovarian steroidogenesis_Homo sapiens_hsa049130.73133485
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71293764
65beta-Alanine metabolism_Homo sapiens_hsa004100.70778322
66Sulfur metabolism_Homo sapiens_hsa009200.70324046
67Purine metabolism_Homo sapiens_hsa002300.68382898
68Salivary secretion_Homo sapiens_hsa049700.67148326
69Primary immunodeficiency_Homo sapiens_hsa053400.66868305
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65695590
71Collecting duct acid secretion_Homo sapiens_hsa049660.62946886
72Histidine metabolism_Homo sapiens_hsa003400.62266822
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61242094
74Fatty acid biosynthesis_Homo sapiens_hsa000610.61177230
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59287916
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57047060
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56696023
78Type I diabetes mellitus_Homo sapiens_hsa049400.56627252
79Dopaminergic synapse_Homo sapiens_hsa047280.55255538
80Fat digestion and absorption_Homo sapiens_hsa049750.51659329
81Cocaine addiction_Homo sapiens_hsa050300.51564335
82Cholinergic synapse_Homo sapiens_hsa047250.50356900
83Metabolic pathways_Homo sapiens_hsa011000.49551936
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49133016
85Pyrimidine metabolism_Homo sapiens_hsa002400.48781753
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47351437
87Long-term depression_Homo sapiens_hsa047300.46801632
88Graft-versus-host disease_Homo sapiens_hsa053320.45416551
89Circadian rhythm_Homo sapiens_hsa047100.43326457
90Allograft rejection_Homo sapiens_hsa053300.42130005
91Steroid biosynthesis_Homo sapiens_hsa001000.41004658
92Autoimmune thyroid disease_Homo sapiens_hsa053200.40019503
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39976092
94Mineral absorption_Homo sapiens_hsa049780.39362342
95Amphetamine addiction_Homo sapiens_hsa050310.39322822
96cAMP signaling pathway_Homo sapiens_hsa040240.38586899
97Sulfur relay system_Homo sapiens_hsa041220.38166889
98Hedgehog signaling pathway_Homo sapiens_hsa043400.37777553
99Fatty acid degradation_Homo sapiens_hsa000710.34373432
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32698513

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