ZNF526

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of nuclear cell cycle DNA replication (GO:0033262)4.55698557
2piRNA metabolic process (GO:0034587)4.49437201
3DNA methylation involved in gamete generation (GO:0043046)4.07639256
4meiotic chromosome segregation (GO:0045132)3.98989282
5cornea development in camera-type eye (GO:0061303)3.94080951
6somatic hypermutation of immunoglobulin genes (GO:0016446)3.92991621
7somatic diversification of immune receptors via somatic mutation (GO:0002566)3.92991621
8regulation of meiosis I (GO:0060631)3.63928860
9behavioral response to nicotine (GO:0035095)3.55026843
10pseudouridine synthesis (GO:0001522)3.52998063
11water-soluble vitamin biosynthetic process (GO:0042364)3.45599963
12DNA replication checkpoint (GO:0000076)3.41806589
13rRNA methylation (GO:0031167)3.41778712
14DNA alkylation (GO:0006305)3.41007618
15DNA methylation (GO:0006306)3.41007618
16peptidyl-histidine modification (GO:0018202)3.39118281
17regulation of hippo signaling (GO:0035330)3.37836216
18negative regulation of telomere maintenance (GO:0032205)3.36927459
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35936411
20preassembly of GPI anchor in ER membrane (GO:0016254)3.30146803
21DNA deamination (GO:0045006)3.29914002
22double-strand break repair via homologous recombination (GO:0000724)3.26941379
23recombinational repair (GO:0000725)3.23727496
24replication fork processing (GO:0031297)3.21315238
25synapsis (GO:0007129)3.20941267
26L-fucose catabolic process (GO:0042355)3.19029960
27fucose catabolic process (GO:0019317)3.19029960
28L-fucose metabolic process (GO:0042354)3.19029960
29regulation of DNA endoreduplication (GO:0032875)3.17799857
30mitochondrial RNA metabolic process (GO:0000959)3.11577170
31rRNA modification (GO:0000154)3.11008271
32respiratory chain complex IV assembly (GO:0008535)3.08499222
33positive regulation of defense response to virus by host (GO:0002230)3.08282557
34cytochrome complex assembly (GO:0017004)3.07676941
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06420135
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.06420135
37regulation of translation, ncRNA-mediated (GO:0045974)3.06420135
38platelet dense granule organization (GO:0060155)3.05736353
39indolalkylamine metabolic process (GO:0006586)3.04275175
40DNA methylation or demethylation (GO:0044728)3.03447015
41ubiquinone biosynthetic process (GO:0006744)3.01164254
42histone H2A acetylation (GO:0043968)3.00544797
43tRNA processing (GO:0008033)3.00250246
44ncRNA 3-end processing (GO:0043628)2.99815014
45male meiosis I (GO:0007141)2.99251703
46DNA modification (GO:0006304)2.96985940
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95612111
48negative regulation of DNA-dependent DNA replication (GO:2000104)2.95590630
49regulation of telomere maintenance (GO:0032204)2.91527798
50opioid receptor signaling pathway (GO:0038003)2.91101063
51mannosylation (GO:0097502)2.90834072
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88774941
53mitochondrial respiratory chain complex assembly (GO:0033108)2.88674385
54protein complex biogenesis (GO:0070271)2.88246691
55basic amino acid transport (GO:0015802)2.87352174
56tRNA modification (GO:0006400)2.84548654
57reciprocal DNA recombination (GO:0035825)2.82964816
58reciprocal meiotic recombination (GO:0007131)2.82964816
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78995814
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78995814
61transcription from mitochondrial promoter (GO:0006390)2.78857911
62ubiquinone metabolic process (GO:0006743)2.76234216
63termination of RNA polymerase I transcription (GO:0006363)2.74262886
64protein-cofactor linkage (GO:0018065)2.73473863
65transcription elongation from RNA polymerase I promoter (GO:0006362)2.71252282
66DNA replication-dependent nucleosome assembly (GO:0006335)2.70891759
67DNA replication-dependent nucleosome organization (GO:0034723)2.70891759
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.69246895
69termination of RNA polymerase III transcription (GO:0006386)2.69246895
70L-methionine salvage (GO:0071267)2.66247589
71L-methionine biosynthetic process (GO:0071265)2.66247589
72amino acid salvage (GO:0043102)2.66247589
73RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.64310012
74protein polyglutamylation (GO:0018095)2.61546563
75anterograde synaptic vesicle transport (GO:0048490)2.61167791
76ribosome biogenesis (GO:0042254)2.60956112
77regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.60405727
78ncRNA catabolic process (GO:0034661)2.58218867
79positive regulation of prostaglandin secretion (GO:0032308)2.57324537
80rRNA catabolic process (GO:0016075)2.55589588
81gene silencing by RNA (GO:0031047)2.55464987
82NADH dehydrogenase complex assembly (GO:0010257)2.54748012
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54748012
84mitochondrial respiratory chain complex I assembly (GO:0032981)2.54748012
85tRNA metabolic process (GO:0006399)2.54219678
86chromosome organization involved in meiosis (GO:0070192)2.52233328
87histone H3-K9 methylation (GO:0051567)2.51863664
88protein K6-linked ubiquitination (GO:0085020)2.51215840
89ncRNA processing (GO:0034470)2.50327707
90somatic diversification of immunoglobulins (GO:0016445)2.50274396
91snRNA processing (GO:0016180)2.50222626
92DNA recombination (GO:0006310)2.49370806
93DNA double-strand break processing (GO:0000729)2.48559615
94transcription from RNA polymerase I promoter (GO:0006360)2.47144453
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47018024
96regulation of mitotic spindle checkpoint (GO:1903504)2.47018024
97phosphatidylglycerol biosynthetic process (GO:0006655)2.45608218
98cellular ketone body metabolic process (GO:0046950)2.44904561
99ncRNA metabolic process (GO:0034660)2.44563950
100axoneme assembly (GO:0035082)2.43957793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NOTCH1_21737748_ChIP-Seq_TLL_Human4.71296545
2* ZNF274_21170338_ChIP-Seq_K562_Hela4.34488878
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85150335
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78665307
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.68529397
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.48981336
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.47851190
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.33744855
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.28364229
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11398778
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88051188
12VDR_23849224_ChIP-Seq_CD4+_Human2.66029048
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57525068
14FOXP3_21729870_ChIP-Seq_TREG_Human2.42785048
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42166878
16E2F7_22180533_ChIP-Seq_HELA_Human2.30972266
17GABP_19822575_ChIP-Seq_HepG2_Human2.28573307
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.22589825
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.16728211
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14570215
21DCP1A_22483619_ChIP-Seq_HELA_Human2.13742842
22KDM5A_27292631_Chip-Seq_BREAST_Human2.13554449
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12835781
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12246712
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11785880
26MYC_18940864_ChIP-ChIP_HL60_Human2.07601322
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96862310
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90966821
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.86111911
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85692527
31VDR_22108803_ChIP-Seq_LS180_Human1.81542379
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66833970
33CIITA_25753668_ChIP-Seq_RAJI_Human1.65485241
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64318737
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62299705
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61373398
37TTF2_22483619_ChIP-Seq_HELA_Human1.59350799
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56612356
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55923185
40ELK1_19687146_ChIP-ChIP_HELA_Human1.54757755
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.54521531
42E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.53753433
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.52357509
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51828362
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51646855
46TP53_22573176_ChIP-Seq_HFKS_Human1.49877497
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49050023
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44447484
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41810715
50IRF1_19129219_ChIP-ChIP_H3396_Human1.40972827
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39481700
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37587018
53XRN2_22483619_ChIP-Seq_HELA_Human1.37073319
54* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36809514
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.36153986
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35270504
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34956659
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33949954
59ERA_21632823_ChIP-Seq_H3396_Human1.29711950
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.29035915
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28742885
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24426256
63PHF8_20622854_ChIP-Seq_HELA_Human1.24258143
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23157155
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19062729
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17328854
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16548438
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.16392249
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16100079
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15770098
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14578605
72* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14447065
73EWS_26573619_Chip-Seq_HEK293_Human1.13490132
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11906972
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11402442
76HOXB7_26014856_ChIP-Seq_BT474_Human1.09627197
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.09026139
78E2F1_20622854_ChIP-Seq_HELA_Human1.08218133
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06838483
80RAC3_21632823_ChIP-Seq_H3396_Human1.04885867
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04365703
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01137552
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.00205718
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98960570
85FOXM1_23109430_ChIP-Seq_U2OS_Human0.98036168
86P53_21459846_ChIP-Seq_SAOS-2_Human0.94781679
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.94561055
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91816478
89BCL6_27268052_Chip-Seq_Bcells_Human0.88576670
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88404852
91P68_20966046_ChIP-Seq_HELA_Human0.87696092
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87343565
93NCOR_22424771_ChIP-Seq_293T_Human0.87208128
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83635632
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83492095
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83362854
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82892238
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82759684
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.82185545
100MYC_19829295_ChIP-Seq_ESCs_Human0.81146749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.81973679
2MP0002163_abnormal_gland_morphology3.20255970
3MP0003787_abnormal_imprinting3.02448263
4MP0005075_abnormal_melanosome_morpholog2.79970469
5MP0005645_abnormal_hypothalamus_physiol2.78370209
6MP0008058_abnormal_DNA_repair2.74326251
7MP0003693_abnormal_embryo_hatching2.71685093
8MP0003718_maternal_effect2.54176426
9MP0003646_muscle_fatigue2.26584814
10MP0000015_abnormal_ear_pigmentation2.11424888
11MP0000372_irregular_coat_pigmentation2.05909630
12MP0002938_white_spotting2.05702632
13MP0005174_abnormal_tail_pigmentation2.02467238
14MP0009278_abnormal_bone_marrow2.01422456
15MP0004133_heterotaxia1.97546077
16MP0010094_abnormal_chromosome_stability1.97073134
17MP0003111_abnormal_nucleus_morphology1.96653628
18MP0008057_abnormal_DNA_replication1.94168196
19MP0003195_calcinosis1.92412962
20MP0002653_abnormal_ependyma_morphology1.90228079
21MP0004381_abnormal_hair_follicle1.89987999
22MP0001529_abnormal_vocalization1.88817884
23MP0000569_abnormal_digit_pigmentation1.83559323
24MP0000427_abnormal_hair_cycle1.83081883
25MP0002160_abnormal_reproductive_system1.80504185
26MP0002210_abnormal_sex_determination1.79585771
27MP0004043_abnormal_pH_regulation1.77378900
28MP0001919_abnormal_reproductive_system1.68256463
29MP0006292_abnormal_olfactory_placode1.67929852
30MP0005310_abnormal_salivary_gland1.65841933
31MP0005379_endocrine/exocrine_gland_phen1.58399441
32MP0009840_abnormal_foam_cell1.54892691
33MP0003786_premature_aging1.52406529
34MP0008961_abnormal_basal_metabolism1.49703542
35MP0005551_abnormal_eye_electrophysiolog1.47709139
36MP0002876_abnormal_thyroid_physiology1.47549492
37MP0005389_reproductive_system_phenotype1.47528577
38MP0001764_abnormal_homeostasis1.46697753
39MP0004147_increased_porphyrin_level1.46362888
40MP0006072_abnormal_retinal_apoptosis1.38954257
41MP0001986_abnormal_taste_sensitivity1.36821880
42MP0000371_diluted_coat_color1.30576367
43MP0001324_abnormal_eye_pigmentation1.29798829
44MP0003806_abnormal_nucleotide_metabolis1.28877950
45MP0001145_abnormal_male_reproductive1.28526918
46MP0002254_reproductive_system_inflammat1.28466647
47MP0008789_abnormal_olfactory_epithelium1.26623512
48MP0003121_genomic_imprinting1.25632194
49MP0000653_abnormal_sex_gland1.25488914
50MP0001929_abnormal_gametogenesis1.24115422
51MP0001968_abnormal_touch/_nociception1.21929861
52MP0003077_abnormal_cell_cycle1.20594458
53MP0002102_abnormal_ear_morphology1.20580527
54MP0000631_abnormal_neuroendocrine_gland1.13935428
55MP0002138_abnormal_hepatobiliary_system1.13607006
56MP0008872_abnormal_physiological_respon1.11942997
57MP0001119_abnormal_female_reproductive1.09517975
58MP0004742_abnormal_vestibular_system1.07517218
59MP0002751_abnormal_autonomic_nervous1.06201612
60MP0005395_other_phenotype1.03940074
61MP0002736_abnormal_nociception_after1.02275960
62MP0008875_abnormal_xenobiotic_pharmacok1.02172200
63MP0002075_abnormal_coat/hair_pigmentati0.99658050
64MP0003698_abnormal_male_reproductive0.97395255
65MP0009333_abnormal_splenocyte_physiolog0.96353690
66MP0010307_abnormal_tumor_latency0.96122696
67MP0003943_abnormal_hepatobiliary_system0.95860414
68MP0000538_abnormal_urinary_bladder0.95810968
69MP0001944_abnormal_pancreas_morphology0.93893504
70MP0006035_abnormal_mitochondrial_morpho0.91632491
71MP0003119_abnormal_digestive_system0.90809175
72MP0002095_abnormal_skin_pigmentation0.87864291
73MP0002089_abnormal_postnatal_growth/wei0.87487066
74MP0005220_abnormal_exocrine_pancreas0.86933252
75MP0000358_abnormal_cell_content/0.86580729
76MP0002277_abnormal_respiratory_mucosa0.85786218
77MP0005646_abnormal_pituitary_gland0.84929210
78MP0003136_yellow_coat_color0.84904750
79MP0001545_abnormal_hematopoietic_system0.84026654
80MP0005397_hematopoietic_system_phenotyp0.84026654
81MP0003937_abnormal_limbs/digits/tail_de0.83304338
82MP0000647_abnormal_sebaceous_gland0.82985510
83MP0008007_abnormal_cellular_replicative0.81555897
84MP0002837_dystrophic_cardiac_calcinosis0.80043025
85MP0002693_abnormal_pancreas_physiology0.79740589
86MP0003890_abnormal_embryonic-extraembry0.78330833
87MP0005253_abnormal_eye_physiology0.77279704
88MP0004197_abnormal_fetal_growth/weight/0.76697595
89MP0000490_abnormal_crypts_of0.74338993
90MP0000383_abnormal_hair_follicle0.72502377
91MP0004957_abnormal_blastocyst_morpholog0.71661757
92MP0003942_abnormal_urinary_system0.70047602
93MP0004924_abnormal_behavior0.69425812
94MP0005386_behavior/neurological_phenoty0.69425812
95MP0004142_abnormal_muscle_tone0.69219115
96MP0002822_catalepsy0.69165779
97MP0010386_abnormal_urinary_bladder0.68791291
98MP0005266_abnormal_metabolism0.68581921
99MP0008995_early_reproductive_senescence0.68306528
100MP0003123_paternal_imprinting0.67993406

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.85842451
2Patellar aplasia (HP:0006443)3.11241621
3Type II lissencephaly (HP:0007260)3.06827890
4Neoplasm of the adrenal cortex (HP:0100641)3.04718175
5Molar tooth sign on MRI (HP:0002419)3.01831211
6Abnormality of midbrain morphology (HP:0002418)3.01831211
7Aplasia/Hypoplasia of the patella (HP:0006498)2.94867429
8Hypoplasia of the pons (HP:0012110)2.93173696
9Pancreatic cysts (HP:0001737)2.90324529
10Progressive inability to walk (HP:0002505)2.87588296
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75264067
12Abnormality of DNA repair (HP:0003254)2.70770013
13Lissencephaly (HP:0001339)2.66745210
14Methylmalonic aciduria (HP:0012120)2.61190527
15Cerebellar dysplasia (HP:0007033)2.58393058
16Abnormality of the pons (HP:0007361)2.58305488
17Absent thumb (HP:0009777)2.58068183
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.52784441
19Albinism (HP:0001022)2.52731369
20Chromsome breakage (HP:0040012)2.52586574
21Abnormal rod and cone electroretinograms (HP:0008323)2.49417257
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45367492
23Increased CSF lactate (HP:0002490)2.43357165
24Pendular nystagmus (HP:0012043)2.42113505
25Attenuation of retinal blood vessels (HP:0007843)2.41417266
26Birth length less than 3rd percentile (HP:0003561)2.38523793
27Inability to walk (HP:0002540)2.37006026
28Severe visual impairment (HP:0001141)2.36025691
29Tubular atrophy (HP:0000092)2.35612907
30Ectopic kidney (HP:0000086)2.34282977
31Poikiloderma (HP:0001029)2.31667397
32Methylmalonic acidemia (HP:0002912)2.29055770
33Abnormality of the labia minora (HP:0012880)2.26607579
34Progressive microcephaly (HP:0000253)2.26261566
35Abnormality of the ileum (HP:0001549)2.24739159
36Pancreatic fibrosis (HP:0100732)2.22471865
37Ketosis (HP:0001946)2.22193925
38Nephronophthisis (HP:0000090)2.22172941
39Abnormality of the carotid arteries (HP:0005344)2.18084116
40Clumsiness (HP:0002312)2.16170536
41Limb hypertonia (HP:0002509)2.11851577
42Colon cancer (HP:0003003)2.11357159
43Abnormal number of erythroid precursors (HP:0012131)2.08266419
44Abnormality of the preputium (HP:0100587)2.07565839
45Ketoacidosis (HP:0001993)2.07231047
46Increased serum lactate (HP:0002151)2.06326912
473-Methylglutaconic aciduria (HP:0003535)2.06138756
48Pachygyria (HP:0001302)2.06006331
49Squamous cell carcinoma (HP:0002860)2.05989766
50Acute necrotizing encephalopathy (HP:0006965)2.05549987
51Mitochondrial inheritance (HP:0001427)2.04810624
52Abnormality of the renal medulla (HP:0100957)2.04049719
53Meckel diverticulum (HP:0002245)2.03889291
54Severe muscular hypotonia (HP:0006829)2.03478321
55Acute encephalopathy (HP:0006846)2.03255066
56Abnormality of the renal cortex (HP:0011035)2.01055410
57Bilateral microphthalmos (HP:0007633)2.00613607
58Short thumb (HP:0009778)1.99222653
59Ependymoma (HP:0002888)1.98327874
60Acute lymphatic leukemia (HP:0006721)1.97739418
61Intestinal atresia (HP:0011100)1.97496530
62Horseshoe kidney (HP:0000085)1.97495478
63Abnormal biliary tract physiology (HP:0012439)1.96029887
64Bile duct proliferation (HP:0001408)1.96029887
65Hepatocellular necrosis (HP:0001404)1.94278275
66Chronic hepatic failure (HP:0100626)1.93163196
67Sloping forehead (HP:0000340)1.92197183
68Abnormal mitochondria in muscle tissue (HP:0008316)1.91810807
69Broad-based gait (HP:0002136)1.89926315
70Lipid accumulation in hepatocytes (HP:0006561)1.89333116
71True hermaphroditism (HP:0010459)1.89060452
72Hypothermia (HP:0002045)1.88493379
73Volvulus (HP:0002580)1.88188547
74Anencephaly (HP:0002323)1.86856594
75Hyperventilation (HP:0002883)1.86663730
76Protruding tongue (HP:0010808)1.85561685
77Duplicated collecting system (HP:0000081)1.85145070
78Concave nail (HP:0001598)1.84136482
79Small hand (HP:0200055)1.83872662
80Disproportionate short-trunk short stature (HP:0003521)1.82282019
81Sclerocornea (HP:0000647)1.81195784
82Medial flaring of the eyebrow (HP:0010747)1.80568064
83Dandy-Walker malformation (HP:0001305)1.79519972
84Premature ovarian failure (HP:0008209)1.78324353
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78171813
86Gaze-evoked nystagmus (HP:0000640)1.73563433
87Agitation (HP:0000713)1.73303909
88Large for gestational age (HP:0001520)1.72418267
89Cleft eyelid (HP:0000625)1.71741250
90Abnormal albumin level (HP:0012116)1.71501078
91Hypoalbuminemia (HP:0003073)1.71501078
92Abnormality of the pancreatic islet cells (HP:0006476)1.71117361
93Abnormality of endocrine pancreas physiology (HP:0012093)1.71117361
94Nephrogenic diabetes insipidus (HP:0009806)1.70842786
95Abnormality of the renal collecting system (HP:0004742)1.69852883
96Progressive macrocephaly (HP:0004481)1.69613817
97Cystic liver disease (HP:0006706)1.69349785
98Microretrognathia (HP:0000308)1.68622823
99Tented upper lip vermilion (HP:0010804)1.68040676
100Hypergonadotropic hypogonadism (HP:0000815)1.66449802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.15214564
2FRK3.97560694
3TAOK33.80471059
4ZAK3.69888295
5BMPR1B3.69476297
6TLK13.06698191
7NUAK12.87490636
8ACVR1B2.68941349
9BUB12.60677382
10MUSK2.35227152
11WNK42.32802625
12NME12.30732779
13VRK22.21216599
14WNK32.20145217
15MAP4K22.16080331
16GRK11.95628172
17MAP4K11.95619060
18IRAK31.71948501
19MAP3K111.45724807
20CDK81.43127766
21TGFBR11.39908453
22CDC71.38556550
23CAMK1G1.36015325
24PRKCI1.35450422
25CAMK1D1.34079914
26CHEK21.28314701
27TRIM281.25710827
28PIM21.12502754
29SMG11.11979501
30IKBKB1.08044476
31PLK11.07196083
32MAP2K21.06331815
33TAF11.02620108
34BCKDK1.02588877
35ATR0.99866008
36PRKD20.98714309
37CHUK0.98207947
38NEK20.90522967
39MAPKAPK50.85848500
40INSRR0.85683675
41PLK40.85635981
42VRK10.81356409
43CASK0.79644882
44DYRK20.77207797
45RPS6KA50.76829559
46SIK20.75446455
47OXSR10.75041384
48CDK90.73380592
49TNIK0.72648886
50PHKG20.72223678
51PHKG10.72223678
52PNCK0.70760478
53CDK70.70698172
54TNK20.70068236
55STK390.69981698
56PINK10.69362697
57AURKA0.67137731
58MAPK130.65453195
59CHEK10.63069643
60TAOK10.62138278
61TTK0.60097685
62ADRBK10.59122807
63STK160.58643141
64PIM10.58381586
65CLK10.57840512
66STK30.55708291
67MAPK110.55096598
68PBK0.54347231
69STK40.53928801
70PRKAA10.51837881
71EIF2AK10.51831037
72DYRK30.49955762
73MKNK20.48562018
74MAP2K60.48214666
75PLK30.46441307
76PAK30.44979729
77FLT30.44359877
78RPS6KA60.44250928
79HIPK20.43896925
80ATM0.42915029
81PKN10.42666597
82STK110.41812176
83PRKAA20.40917851
84AURKB0.40762681
85CAMK40.40167029
86RPS6KA10.36706498
87CSNK1G10.36352640
88CDK120.35584872
89MAPKAPK30.34551506
90TXK0.33103149
91CDK40.32894855
92IRAK40.32088506
93KIT0.31681625
94MET0.31540284
95CDK20.31183155
96MARK30.30959163
97LMTK20.30665671
98MATK0.28352380
99MELK0.27758266
100CDK10.26639285

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.39987165
2Homologous recombination_Homo sapiens_hsa034403.36356066
3RNA polymerase_Homo sapiens_hsa030203.09131175
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06701305
5Selenocompound metabolism_Homo sapiens_hsa004502.85444480
6Fanconi anemia pathway_Homo sapiens_hsa034602.80378614
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68776124
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65186369
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.60711261
10Base excision repair_Homo sapiens_hsa034102.39099410
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.30970226
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.26493339
13Non-homologous end-joining_Homo sapiens_hsa034502.21280939
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16101488
15Phototransduction_Homo sapiens_hsa047442.11979857
16Sulfur relay system_Homo sapiens_hsa041221.99645588
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91472139
18RNA degradation_Homo sapiens_hsa030181.87576996
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82355473
20Mismatch repair_Homo sapiens_hsa034301.80666115
21DNA replication_Homo sapiens_hsa030301.76784127
22RNA transport_Homo sapiens_hsa030131.71609221
23Nucleotide excision repair_Homo sapiens_hsa034201.69171379
24Sulfur metabolism_Homo sapiens_hsa009201.59524299
25Pyrimidine metabolism_Homo sapiens_hsa002401.59303539
26One carbon pool by folate_Homo sapiens_hsa006701.57528858
27Ether lipid metabolism_Homo sapiens_hsa005651.55223860
28Oxidative phosphorylation_Homo sapiens_hsa001901.42572237
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40570842
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34386682
31Cell cycle_Homo sapiens_hsa041101.23585914
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17771597
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17261512
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.16844806
35Lysine degradation_Homo sapiens_hsa003101.16736669
36p53 signaling pathway_Homo sapiens_hsa041151.16450933
37Regulation of autophagy_Homo sapiens_hsa041401.14502522
38Purine metabolism_Homo sapiens_hsa002301.08968799
39Primary immunodeficiency_Homo sapiens_hsa053401.07359691
40Huntingtons disease_Homo sapiens_hsa050161.05616362
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05444765
42Spliceosome_Homo sapiens_hsa030401.01418155
43Nitrogen metabolism_Homo sapiens_hsa009101.00100290
44Linoleic acid metabolism_Homo sapiens_hsa005910.99595933
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98959758
46Sphingolipid metabolism_Homo sapiens_hsa006000.98750653
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.98587590
48Parkinsons disease_Homo sapiens_hsa050120.97863211
49Proteasome_Homo sapiens_hsa030500.93749392
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92831290
51Steroid biosynthesis_Homo sapiens_hsa001000.88735069
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87027430
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.86685296
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86293106
55Protein export_Homo sapiens_hsa030600.85930257
56Butanoate metabolism_Homo sapiens_hsa006500.84725193
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83734631
58N-Glycan biosynthesis_Homo sapiens_hsa005100.78563936
59Basal cell carcinoma_Homo sapiens_hsa052170.71267399
60Tryptophan metabolism_Homo sapiens_hsa003800.70010645
61Hedgehog signaling pathway_Homo sapiens_hsa043400.69523000
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68220741
63Metabolic pathways_Homo sapiens_hsa011000.67494767
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61535250
65Dorso-ventral axis formation_Homo sapiens_hsa043200.57164950
66Collecting duct acid secretion_Homo sapiens_hsa049660.57071308
67Systemic lupus erythematosus_Homo sapiens_hsa053220.55634670
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51301985
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42964473
70Ovarian steroidogenesis_Homo sapiens_hsa049130.42947578
71ABC transporters_Homo sapiens_hsa020100.41878328
72mRNA surveillance pathway_Homo sapiens_hsa030150.41860346
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40879656
74Fructose and mannose metabolism_Homo sapiens_hsa000510.39948655
75Epstein-Barr virus infection_Homo sapiens_hsa051690.39653714
76Alcoholism_Homo sapiens_hsa050340.37868834
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37483126
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36171154
79Lysosome_Homo sapiens_hsa041420.36124195
80Fatty acid elongation_Homo sapiens_hsa000620.36116817
81Arachidonic acid metabolism_Homo sapiens_hsa005900.35709966
82Melanoma_Homo sapiens_hsa052180.35147993
83Vitamin B6 metabolism_Homo sapiens_hsa007500.34921195
84Alzheimers disease_Homo sapiens_hsa050100.33046892
85Fatty acid biosynthesis_Homo sapiens_hsa000610.32258970
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31992222
87Vitamin digestion and absorption_Homo sapiens_hsa049770.31934481
88Peroxisome_Homo sapiens_hsa041460.31432887
89Taste transduction_Homo sapiens_hsa047420.30106074
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.29375435
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.26785099
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22956890
93TGF-beta signaling pathway_Homo sapiens_hsa043500.21491716
94Olfactory transduction_Homo sapiens_hsa047400.21159003
95African trypanosomiasis_Homo sapiens_hsa051430.20549853
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.20243714
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.19288418
98Viral carcinogenesis_Homo sapiens_hsa052030.18838481
99Bladder cancer_Homo sapiens_hsa052190.18400869
100Fatty acid metabolism_Homo sapiens_hsa012120.16498864

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