ZNF521

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.74276607
2neuron projection extension involved in neuron projection guidance (GO:1902284)4.41576919
3axon extension involved in axon guidance (GO:0048846)4.41576919
4presynaptic membrane assembly (GO:0097105)4.34484487
5retinal ganglion cell axon guidance (GO:0031290)4.20296098
6postsynaptic membrane organization (GO:0001941)4.14156252
7presynaptic membrane organization (GO:0097090)4.07943485
8axonal fasciculation (GO:0007413)3.85122279
9dendritic spine morphogenesis (GO:0060997)3.68854585
10neuron recognition (GO:0008038)3.60252426
11negative regulation of axon guidance (GO:1902668)3.59425769
12nucleobase catabolic process (GO:0046113)3.52348634
13lateral sprouting from an epithelium (GO:0060601)3.47140088
14neuronal stem cell maintenance (GO:0097150)3.43921994
15limb bud formation (GO:0060174)3.40526544
16vocalization behavior (GO:0071625)3.34802551
17transmission of nerve impulse (GO:0019226)3.34467514
18intraciliary transport (GO:0042073)3.32651540
19neuron cell-cell adhesion (GO:0007158)3.31201794
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.26941205
21nonmotile primary cilium assembly (GO:0035058)3.26776683
22spinal cord development (GO:0021510)3.22230470
23central nervous system projection neuron axonogenesis (GO:0021952)3.17362037
24regulation of non-canonical Wnt signaling pathway (GO:2000050)3.16349332
25establishment of mitochondrion localization (GO:0051654)3.08557117
26calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.05864279
27somite development (GO:0061053)3.05339500
28appendage development (GO:0048736)3.03199995
29limb development (GO:0060173)3.03199995
30protein localization to synapse (GO:0035418)3.01946468
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99328085
32regulation of axon guidance (GO:1902667)2.98576496
33neurotransmitter-gated ion channel clustering (GO:0072578)2.98421903
34negative chemotaxis (GO:0050919)2.97329733
35positive regulation of synapse assembly (GO:0051965)2.94398851
36auditory behavior (GO:0031223)2.93717184
37spinal cord association neuron differentiation (GO:0021527)2.90805670
38cerebral cortex radially oriented cell migration (GO:0021799)2.90668335
39positive regulation of gastrulation (GO:2000543)2.87230040
40regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.82047672
41mechanosensory behavior (GO:0007638)2.80419252
42cell proliferation in forebrain (GO:0021846)2.80115002
43artery development (GO:0060840)2.77005019
44neuronal action potential propagation (GO:0019227)2.75232725
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.73571198
46short-term memory (GO:0007614)2.71454480
47neuron fate determination (GO:0048664)2.71314795
48epithelial cilium movement (GO:0003351)2.71068947
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69964979
50tongue development (GO:0043586)2.67927788
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67681112
52axon extension (GO:0048675)2.66565535
53camera-type eye morphogenesis (GO:0048593)2.65795409
54mitochondrion transport along microtubule (GO:0047497)2.62947062
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62947062
56smoothened signaling pathway (GO:0007224)2.60561423
57cell migration in hindbrain (GO:0021535)2.59275749
58negative regulation of axon extension involved in axon guidance (GO:0048843)2.58513985
59olfactory bulb development (GO:0021772)2.58425840
60cranial nerve morphogenesis (GO:0021602)2.58021057
61otic vesicle formation (GO:0030916)2.57910280
62synapse assembly (GO:0007416)2.57333846
63heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.55691323
64forebrain neuron differentiation (GO:0021879)2.48168592
65dendrite morphogenesis (GO:0048813)2.47099903
66paraxial mesoderm development (GO:0048339)2.45854594
67central nervous system neuron axonogenesis (GO:0021955)2.45838512
68regulation of synapse structural plasticity (GO:0051823)2.43575335
69sequestering of actin monomers (GO:0042989)2.41336170
70positive regulation of neuroblast proliferation (GO:0002052)2.40991826
71DNA integration (GO:0015074)2.40828012
72regulation of collateral sprouting (GO:0048670)2.37628949
73outer ear morphogenesis (GO:0042473)2.37249233
74adult walking behavior (GO:0007628)2.36579682
75locomotory exploration behavior (GO:0035641)2.35744748
76neuron migration (GO:0001764)2.33837991
77neuronal ion channel clustering (GO:0045161)2.33323822
78establishment of nucleus localization (GO:0040023)2.33219798
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.32800572
80establishment of planar polarity (GO:0001736)2.32387237
81establishment of tissue polarity (GO:0007164)2.32387237
82inner ear receptor stereocilium organization (GO:0060122)2.31822604
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.30842312
84behavioral fear response (GO:0001662)2.30672272
85behavioral defense response (GO:0002209)2.30672272
86convergent extension (GO:0060026)2.30339086
87cilium movement (GO:0003341)2.30300587
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.30247402
89regulation of axon extension involved in axon guidance (GO:0048841)2.29916189
90head development (GO:0060322)2.29874327
91midbrain development (GO:0030901)2.29491812
92cilium morphogenesis (GO:0060271)2.28841589
93dendrite development (GO:0016358)2.28784357
94positive regulation of dendritic spine morphogenesis (GO:0061003)2.27279747
95lung-associated mesenchyme development (GO:0060484)2.25473160
96homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.25454641
97behavioral response to nicotine (GO:0035095)2.25063373
98positive regulation of male gonad development (GO:2000020)2.23718332
99lens fiber cell development (GO:0070307)2.23709214
100hindlimb morphogenesis (GO:0035137)2.23488617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.33038220
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.05093796
3GBX2_23144817_ChIP-Seq_PC3_Human2.96749140
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.95553605
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78585195
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.54917292
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53394544
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48833890
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.46177383
10TAF15_26573619_Chip-Seq_HEK293_Human2.45706671
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40070429
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31237997
13FUS_26573619_Chip-Seq_HEK293_Human2.30952416
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.30073454
15IGF1R_20145208_ChIP-Seq_DFB_Human2.26303830
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23331850
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09628488
18RNF2_27304074_Chip-Seq_NSC_Mouse2.09143532
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.07343455
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01525368
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00597333
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99531819
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99527485
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99527485
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99417486
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94091054
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89854864
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.89383246
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89180155
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85683750
31P300_19829295_ChIP-Seq_ESCs_Human1.83636274
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82292718
33* ZNF274_21170338_ChIP-Seq_K562_Hela1.81177479
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79548651
35EWS_26573619_Chip-Seq_HEK293_Human1.76944631
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74877645
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.71108591
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69455511
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68730489
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67964365
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66008258
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.57221516
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.56847247
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.56454905
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55874321
46REST_21632747_ChIP-Seq_MESCs_Mouse1.53097704
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52658112
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52658112
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.51063948
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50126425
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49461144
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46269433
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45191477
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45032010
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44709066
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41460952
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40980533
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40744069
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.40199565
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37760139
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.35247266
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35031008
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.33597122
64VDR_22108803_ChIP-Seq_LS180_Human1.30955131
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29355738
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.28747402
67SOX9_26525672_Chip-Seq_HEART_Mouse1.25661994
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.21711061
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21558626
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21113693
71STAT3_23295773_ChIP-Seq_U87_Human1.21098778
72LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20037493
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.19845393
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19751396
75AR_25329375_ChIP-Seq_VCAP_Human1.18403471
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17742138
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16389626
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16297465
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16211680
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15983275
81TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15280530
82RUNX2_22187159_ChIP-Seq_PCA_Human1.14867357
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.14167371
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10079136
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.09548660
86AR_21572438_ChIP-Seq_LNCaP_Human1.07436764
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06308104
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05652712
89TCF4_23295773_ChIP-Seq_U87_Human1.04132520
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.04076891
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.02525490
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02317100
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01870928
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01832748
95SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01144967
96IRF1_19129219_ChIP-ChIP_H3396_Human0.99141736
97WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99009745
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98082601
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97518968
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97459271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.48394483
2MP0006292_abnormal_olfactory_placode3.08712141
3MP0010030_abnormal_orbit_morphology2.98532397
4MP0000778_abnormal_nervous_system2.81261219
5MP0003122_maternal_imprinting2.78149960
6MP0000566_synostosis2.48408012
7MP0001293_anophthalmia2.21020522
8MP0004859_abnormal_synaptic_plasticity2.16731804
9MP0006276_abnormal_autonomic_nervous2.10744264
10MP0004133_heterotaxia1.99382368
11MP0005499_abnormal_olfactory_system1.99349100
12MP0005394_taste/olfaction_phenotype1.99349100
13MP0002938_white_spotting1.95060273
14MP0008789_abnormal_olfactory_epithelium1.89318465
15MP0005423_abnormal_somatic_nervous1.85515330
16MP0003121_genomic_imprinting1.77240656
17MP0002653_abnormal_ependyma_morphology1.75203506
18MP0001529_abnormal_vocalization1.74077996
19MP0000049_abnormal_middle_ear1.73420075
20MP0001486_abnormal_startle_reflex1.72519279
21MP0003787_abnormal_imprinting1.66713908
22MP0003937_abnormal_limbs/digits/tail_de1.60522547
23MP0002233_abnormal_nose_morphology1.56780001
24MP0003635_abnormal_synaptic_transmissio1.54307843
25MP0000631_abnormal_neuroendocrine_gland1.53353707
26MP0005248_abnormal_Harderian_gland1.48249279
27MP0003385_abnormal_body_wall1.44470940
28MP0001984_abnormal_olfaction1.44141856
29MP0000955_abnormal_spinal_cord1.44129378
30MP0009250_abnormal_appendicular_skeleto1.38044934
31MP0002063_abnormal_learning/memory/cond1.36758297
32MP0002184_abnormal_innervation1.35819552
33MP0004885_abnormal_endolymph1.35296503
34MP0001299_abnormal_eye_distance/1.35037112
35MP0006072_abnormal_retinal_apoptosis1.32903011
36MP0002249_abnormal_larynx_morphology1.32816325
37MP0003942_abnormal_urinary_system1.32586280
38MP0003861_abnormal_nervous_system1.31196702
39MP0005171_absent_coat_pigmentation1.30656758
40MP0009379_abnormal_foot_pigmentation1.29608867
41MP0003136_yellow_coat_color1.28671480
42MP0002102_abnormal_ear_morphology1.28080152
43MP0002572_abnormal_emotion/affect_behav1.28028026
44MP0000569_abnormal_digit_pigmentation1.27123586
45MP0003755_abnormal_palate_morphology1.26370483
46MP0003119_abnormal_digestive_system1.26257363
47MP0002152_abnormal_brain_morphology1.25792150
48MP0004145_abnormal_muscle_electrophysio1.25689940
49MP0003938_abnormal_ear_development1.25670145
50MP0010368_abnormal_lymphatic_system1.25243297
51MP0001286_abnormal_eye_development1.24600356
52MP0002557_abnormal_social/conspecific_i1.24352714
53MP0002272_abnormal_nervous_system1.21381911
54MP0002734_abnormal_mechanical_nocicepti1.20086297
55MP0009745_abnormal_behavioral_response1.18043589
56MP0002697_abnormal_eye_size1.15949867
57MP0002064_seizures1.15459986
58MP0003890_abnormal_embryonic-extraembry1.15396254
59MP0000026_abnormal_inner_ear1.15347771
60MP0000428_abnormal_craniofacial_morphol1.14815288
61MP0004270_analgesia1.14671992
62MP0002752_abnormal_somatic_nervous1.14052180
63MP0002282_abnormal_trachea_morphology1.13924044
64MP0002735_abnormal_chemical_nociception1.13777488
65MP0002932_abnormal_joint_morphology1.13444565
66MP0002882_abnormal_neuron_morphology1.12745683
67MP0000534_abnormal_ureter_morphology1.11618339
68MP0005503_abnormal_tendon_morphology1.10761339
69MP0002116_abnormal_craniofacial_bone1.07426423
70MP0004811_abnormal_neuron_physiology1.06188847
71MP0001968_abnormal_touch/_nociception1.06127114
72MP0002092_abnormal_eye_morphology1.06120498
73MP0002234_abnormal_pharynx_morphology1.03931672
74MP0005391_vision/eye_phenotype1.03902929
75MP0002736_abnormal_nociception_after1.03385837
76MP0009046_muscle_twitch1.02872440
77MP0004142_abnormal_muscle_tone1.02406892
78MP0003567_abnormal_fetal_cardiomyocyte1.01874635
79MP0002067_abnormal_sensory_capabilities0.98970190
80MP0002751_abnormal_autonomic_nervous0.96805353
81MP0003935_abnormal_craniofacial_develop0.96263323
82MP0005551_abnormal_eye_electrophysiolog0.95922035
83MP0001879_abnormal_lymphatic_vessel0.95066032
84MP0001177_atelectasis0.95038118
85MP0000579_abnormal_nail_morphology0.94352571
86MP0000537_abnormal_urethra_morphology0.94045984
87MP0002638_abnormal_pupillary_reflex0.93754776
88MP0005253_abnormal_eye_physiology0.93050998
89MP0002109_abnormal_limb_morphology0.93042254
90MP0005195_abnormal_posterior_eye0.88273061
91MP0001963_abnormal_hearing_physiology0.87973790
92MP0001485_abnormal_pinna_reflex0.87444724
93MP0002081_perinatal_lethality0.87329312
94MP0009053_abnormal_anal_canal0.86765556
95MP0001346_abnormal_lacrimal_gland0.86045625
96MP0002111_abnormal_tail_morphology0.85647490
97MP0005646_abnormal_pituitary_gland0.85183899
98MP0005187_abnormal_penis_morphology0.82235527
99MP0002928_abnormal_bile_duct0.81588246
100MP0008877_abnormal_DNA_methylation0.80343748

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.53593414
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53593414
3Focal motor seizures (HP:0011153)3.01492046
4Abnormality of the 4th metacarpal (HP:0010012)2.99904964
5Septo-optic dysplasia (HP:0100842)2.99551259
6Gait imbalance (HP:0002141)2.91913906
7True hermaphroditism (HP:0010459)2.87523371
8Vitreoretinal degeneration (HP:0000655)2.79743829
9Cutaneous finger syndactyly (HP:0010554)2.79235530
10Vaginal atresia (HP:0000148)2.67859046
11Myokymia (HP:0002411)2.66497588
12Genital tract atresia (HP:0001827)2.65322187
13Congenital primary aphakia (HP:0007707)2.62365578
14Medial flaring of the eyebrow (HP:0010747)2.62091202
15Pancreatic fibrosis (HP:0100732)2.59791244
16Nephronophthisis (HP:0000090)2.56994497
17Colon cancer (HP:0003003)2.54634068
18Cutaneous syndactyly (HP:0012725)2.52332089
19Abnormality of the phalanges of the 2nd finger (HP:0009541)2.42309090
20Nephrogenic diabetes insipidus (HP:0009806)2.37387281
21Abnormality of midbrain morphology (HP:0002418)2.35973079
22Molar tooth sign on MRI (HP:0002419)2.35973079
23Pancreatic cysts (HP:0001737)2.27743954
24Focal seizures (HP:0007359)2.26317801
25Supernumerary spleens (HP:0009799)2.21841042
26Anophthalmia (HP:0000528)2.18864383
27Oligodactyly (HP:0012165)2.16869729
28Optic nerve hypoplasia (HP:0000609)2.16442306
29Abnormality of the renal medulla (HP:0100957)2.12133205
30Stenosis of the external auditory canal (HP:0000402)2.11924772
31Atonic seizures (HP:0010819)2.10549048
32Abnormality of the lower motor neuron (HP:0002366)2.09730369
33Oligodactyly (hands) (HP:0001180)2.09335600
34Broad foot (HP:0001769)2.09148432
35Postaxial hand polydactyly (HP:0001162)2.07492627
36Drooling (HP:0002307)2.06213015
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.05236427
38Rib fusion (HP:0000902)2.03742450
39Renal hypoplasia (HP:0000089)2.03735779
40Postaxial foot polydactyly (HP:0001830)2.02558948
41Abnormality of the labia minora (HP:0012880)2.01888473
42Poor coordination (HP:0002370)2.01214300
43Preaxial foot polydactyly (HP:0001841)2.01007980
44Trigonocephaly (HP:0000243)1.98326963
45Bifid tongue (HP:0010297)1.96210720
46Cortical dysplasia (HP:0002539)1.95267635
47Specific learning disability (HP:0001328)1.94779102
48Cystic liver disease (HP:0006706)1.91375418
49Broad thumb (HP:0011304)1.89366405
50Febrile seizures (HP:0002373)1.87574609
51Broad phalanx (HP:0006009)1.86050044
52Decreased testicular size (HP:0008734)1.85429871
53Aplasia involving bones of the upper limbs (HP:0009823)1.85108928
54Aplasia of the phalanges of the hand (HP:0009802)1.85108928
55Aplasia involving bones of the extremities (HP:0009825)1.85108928
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84906577
57Broad long bones (HP:0005622)1.83856622
58Abnormality of the aortic arch (HP:0012303)1.83832862
59Partial duplication of thumb phalanx (HP:0009944)1.82958221
60Aqueductal stenosis (HP:0002410)1.81722969
61High anterior hairline (HP:0009890)1.81665168
62Broad phalanges of the hand (HP:0009768)1.81616800
63Micropenis (HP:0000054)1.81301254
64Broad finger (HP:0001500)1.80838470
65Absent septum pellucidum (HP:0001331)1.80578557
66Short tibia (HP:0005736)1.79882338
67Morphological abnormality of the middle ear (HP:0008609)1.79281758
68Broad metatarsal (HP:0001783)1.79138976
69Narrow forehead (HP:0000341)1.78843852
70Occipital encephalocele (HP:0002085)1.78616495
71Coronal craniosynostosis (HP:0004440)1.77489240
72Excessive salivation (HP:0003781)1.76964482
73Midline defect of the nose (HP:0004122)1.76062879
74Abnormality of the corticospinal tract (HP:0002492)1.75891552
75Limb dystonia (HP:0002451)1.75657864
76Fibular hypoplasia (HP:0003038)1.74788250
77Aplasia/Hypoplasia of the tibia (HP:0005772)1.74111746
78Partial duplication of the phalanx of hand (HP:0009999)1.73239059
79Preaxial hand polydactyly (HP:0001177)1.72421760
80Wide anterior fontanel (HP:0000260)1.72071510
81Intestinal atresia (HP:0011100)1.70466723
82Short foot (HP:0001773)1.70119766
83Hepatoblastoma (HP:0002884)1.70097633
84Progressive cerebellar ataxia (HP:0002073)1.69245168
85Anencephaly (HP:0002323)1.69034750
86Abnormality of the middle phalanges of the toes (HP:0010183)1.68936389
87Hemivertebrae (HP:0002937)1.68135668
88Hypoplastic pelvis (HP:0008839)1.65568320
89Abnormality of the ischium (HP:0003174)1.64152538
90Growth hormone deficiency (HP:0000824)1.63365208
91Sclerocornea (HP:0000647)1.63297588
92Abnormality of the diencephalon (HP:0010662)1.62761527
93Abnormality of abdominal situs (HP:0011620)1.62339620
94Abdominal situs inversus (HP:0003363)1.62339620
95Aplasia/Hypoplasia of the lens (HP:0008063)1.61040357
96Broad toe (HP:0001837)1.60419091
97Hemiparesis (HP:0001269)1.60352708
98Renal dysplasia (HP:0000110)1.60306638
99Tracheomalacia (HP:0002779)1.58660137
100Abnormality of the septum pellucidum (HP:0007375)1.58653265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.91210010
2MAP4K23.24085669
3CASK3.09514261
4EPHA42.91040324
5TIE12.90784198
6WNK32.86097665
7TNIK2.61758775
8MAP3K42.60974978
9EPHB22.27071484
10MKNK12.24489756
11MAP2K72.02942772
12NTRK21.96951921
13PINK11.96587234
14MKNK21.90948357
15PNCK1.89944615
16DYRK21.79670484
17DYRK31.75715159
18FGFR21.63674331
19UHMK11.58259906
20MAPK131.55095649
21NTRK31.41910357
22MINK11.41267558
23CDK191.39307518
24BCR1.31465633
25PLK21.28628586
26PAK61.23339321
27MAPK151.22698413
28DYRK1A1.20712512
29NUAK11.19881411
30ERBB31.18659270
31TGFBR11.16940219
32BMPR1B1.13990695
33MAP2K41.11878273
34RPS6KA41.06379379
35DYRK1B1.05225264
36SGK2230.99902678
37SGK4940.99902678
38FLT30.99845314
39CSNK1G20.95096061
40SGK20.95076539
41NTRK10.92494268
42TRIM280.91737080
43TYRO30.87716964
44PRKCG0.86062258
45SRPK10.83960137
46PLK30.83815734
47STK38L0.82640860
48ZAK0.82365652
49CDK30.79831192
50BRD40.79112559
51CSNK1G10.76986819
52WEE10.76285484
53PLK40.76069656
54GRK10.73666872
55DAPK20.71968372
56PAK30.71335300
57BCKDK0.70667630
58CSNK1G30.70276607
59STK110.69905464
60PKN10.69697847
61CDK180.68695461
62CDK150.67681310
63CDK11A0.66988753
64CDK50.66855379
65CAMK1G0.65318944
66PIK3CA0.65233781
67PRKCE0.63781592
68CDK140.63103442
69CSNK1A1L0.62313628
70CAMK10.60932934
71MARK20.60132882
72PRKD30.57957448
73VRK10.57079187
74FGFR10.55653185
75CAMK2A0.55360527
76NEK20.53845715
77DDR20.53643062
78CAMK40.51048560
79EPHA30.50624097
80BRSK20.47233212
81INSRR0.45755818
82ERBB20.44577250
83ADRBK20.42380649
84KSR10.40849919
85SGK30.37170961
86LATS10.36138023
87PRKCH0.35643234
88PASK0.35601674
89WNK10.34503454
90PDGFRA0.34404328
91PLK10.33108685
92MAP3K100.32687262
93CHEK20.32183927
94PRKACA0.31469971
95ROCK20.31469384
96PAK20.29752537
97PRKDC0.29605086
98CSNK1E0.29319522
99PRKG10.28773447
100OBSCN0.28450932

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.26188774
2Hedgehog signaling pathway_Homo sapiens_hsa043403.01183195
3Nicotine addiction_Homo sapiens_hsa050332.95812341
4Axon guidance_Homo sapiens_hsa043602.15120650
5Circadian entrainment_Homo sapiens_hsa047132.09757317
6Hippo signaling pathway_Homo sapiens_hsa043901.97398533
7Glutamatergic synapse_Homo sapiens_hsa047241.88248073
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85421432
9GABAergic synapse_Homo sapiens_hsa047271.84619873
10Phototransduction_Homo sapiens_hsa047441.79599003
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.77983621
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76262755
13Morphine addiction_Homo sapiens_hsa050321.76142360
14Cocaine addiction_Homo sapiens_hsa050301.73541071
15Wnt signaling pathway_Homo sapiens_hsa043101.72792899
16Melanogenesis_Homo sapiens_hsa049161.72286799
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66509892
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61181373
19Gap junction_Homo sapiens_hsa045401.57167245
20Taste transduction_Homo sapiens_hsa047421.56687310
21Dopaminergic synapse_Homo sapiens_hsa047281.54406300
22Cardiac muscle contraction_Homo sapiens_hsa042601.49538008
23ECM-receptor interaction_Homo sapiens_hsa045121.38722727
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36184713
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27080304
26Olfactory transduction_Homo sapiens_hsa047401.25976748
27Cholinergic synapse_Homo sapiens_hsa047251.24880444
28Nitrogen metabolism_Homo sapiens_hsa009101.24486853
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24330942
30Insulin secretion_Homo sapiens_hsa049111.23286787
31Long-term depression_Homo sapiens_hsa047301.20223998
32Salivary secretion_Homo sapiens_hsa049701.20195385
33Fanconi anemia pathway_Homo sapiens_hsa034601.19255246
34Amphetamine addiction_Homo sapiens_hsa050311.18674388
35Propanoate metabolism_Homo sapiens_hsa006401.18416462
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16616544
37Protein export_Homo sapiens_hsa030601.15496056
38Dilated cardiomyopathy_Homo sapiens_hsa054141.13989570
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09933485
40Oxytocin signaling pathway_Homo sapiens_hsa049211.08865657
41TGF-beta signaling pathway_Homo sapiens_hsa043501.08781291
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06553518
43Protein digestion and absorption_Homo sapiens_hsa049741.05774795
44Serotonergic synapse_Homo sapiens_hsa047261.04006064
45cAMP signaling pathway_Homo sapiens_hsa040241.03190299
46Renin secretion_Homo sapiens_hsa049240.99629781
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98020843
48Notch signaling pathway_Homo sapiens_hsa043300.96554686
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96366406
50Ribosome_Homo sapiens_hsa030100.95860622
51Colorectal cancer_Homo sapiens_hsa052100.91443786
52Gastric acid secretion_Homo sapiens_hsa049710.90156206
53Calcium signaling pathway_Homo sapiens_hsa040200.89872014
54Dorso-ventral axis formation_Homo sapiens_hsa043200.88512939
55Butanoate metabolism_Homo sapiens_hsa006500.87537351
56Alcoholism_Homo sapiens_hsa050340.83590958
57Synaptic vesicle cycle_Homo sapiens_hsa047210.81632168
58Steroid biosynthesis_Homo sapiens_hsa001000.80186875
59Oocyte meiosis_Homo sapiens_hsa041140.79100098
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77699721
61RNA degradation_Homo sapiens_hsa030180.77340114
62Parkinsons disease_Homo sapiens_hsa050120.75512702
63Pathways in cancer_Homo sapiens_hsa052000.75209337
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73843565
65Tight junction_Homo sapiens_hsa045300.73433980
66Rap1 signaling pathway_Homo sapiens_hsa040150.73362136
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70941088
68Ras signaling pathway_Homo sapiens_hsa040140.69646441
69Adherens junction_Homo sapiens_hsa045200.67943584
70Basal transcription factors_Homo sapiens_hsa030220.67035765
71Huntingtons disease_Homo sapiens_hsa050160.67004200
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65318318
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63587259
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60692042
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60342111
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58993642
77Thyroid hormone synthesis_Homo sapiens_hsa049180.58738608
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56897730
79Oxidative phosphorylation_Homo sapiens_hsa001900.56626459
80mRNA surveillance pathway_Homo sapiens_hsa030150.55931112
81Long-term potentiation_Homo sapiens_hsa047200.55785896
82Lysine degradation_Homo sapiens_hsa003100.55672597
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54674032
84MicroRNAs in cancer_Homo sapiens_hsa052060.54375832
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53382578
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53040215
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.53016212
88Alzheimers disease_Homo sapiens_hsa050100.50741007
89Regulation of autophagy_Homo sapiens_hsa041400.50545421
90Estrogen signaling pathway_Homo sapiens_hsa049150.50326696
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49707627
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47048062
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46764479
94Circadian rhythm_Homo sapiens_hsa047100.44874157
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42541616
96MAPK signaling pathway_Homo sapiens_hsa040100.42157934
97Ether lipid metabolism_Homo sapiens_hsa005650.41559502
98Melanoma_Homo sapiens_hsa052180.41239157
99Ovarian steroidogenesis_Homo sapiens_hsa049130.40155747
100Spliceosome_Homo sapiens_hsa030400.40048584

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