ZNF512

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing four putative zinc finger motifs. Zinc finger motifs may bind to proteins or nucleic acids. Zinc finger-containing proteins are involved in a variety of processes, including regulation of transcription. Alternative splicing results in multiple transcript variants for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.40622349
2nucleobase catabolic process (GO:0046113)4.99574297
3neuron cell-cell adhesion (GO:0007158)4.51405452
4presynaptic membrane assembly (GO:0097105)4.35051132
5DNA double-strand break processing (GO:0000729)4.21464400
6presynaptic membrane organization (GO:0097090)3.88336583
7establishment of mitochondrion localization (GO:0051654)3.87535898
8olfactory bulb development (GO:0021772)3.74223900
9DNA integration (GO:0015074)3.65681090
10behavioral response to nicotine (GO:0035095)3.58008020
11postsynaptic membrane organization (GO:0001941)3.57446772
12intraciliary transport (GO:0042073)3.56786572
13DNA damage response, detection of DNA damage (GO:0042769)3.52255243
14neural tube formation (GO:0001841)3.45688123
15axonal fasciculation (GO:0007413)3.44470071
16nonmotile primary cilium assembly (GO:0035058)3.42302043
17regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.28139471
18epithelial cilium movement (GO:0003351)3.23528213
19limb bud formation (GO:0060174)3.22845607
20positive regulation of mitochondrial fission (GO:0090141)3.18928328
21cell migration in hindbrain (GO:0021535)3.16916040
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12592718
23neuron recognition (GO:0008038)3.08893159
24negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02649458
25protein localization to cilium (GO:0061512)3.00912483
26forebrain neuron differentiation (GO:0021879)2.98538100
27tongue development (GO:0043586)2.97009226
28centriole replication (GO:0007099)2.88575959
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87557155
30mitochondrion transport along microtubule (GO:0047497)2.87557155
31negative regulation of transcription regulatory region DNA binding (GO:2000678)2.86534013
32kidney morphogenesis (GO:0060993)2.86502042
33dendritic spine morphogenesis (GO:0060997)2.85047365
34protein-DNA complex disassembly (GO:0032986)2.84386535
35nucleosome disassembly (GO:0006337)2.84386535
36ubiquinone metabolic process (GO:0006743)2.82086062
37negative regulation of DNA binding (GO:0043392)2.78700850
38gamma-aminobutyric acid transport (GO:0015812)2.78557001
39hippocampus development (GO:0021766)2.76549742
40dendrite development (GO:0016358)2.76193098
41sympathetic nervous system development (GO:0048485)2.74994921
42regulation of development, heterochronic (GO:0040034)2.70313968
43cilium assembly (GO:0042384)2.68654870
44cilium organization (GO:0044782)2.67265528
45cerebral cortex radially oriented cell migration (GO:0021799)2.67006294
46cardiac ventricle formation (GO:0003211)2.65424756
47vocalization behavior (GO:0071625)2.63080620
48negative regulation of DNA recombination (GO:0045910)2.63000998
49ventricular system development (GO:0021591)2.58189457
50histone H3-K9 methylation (GO:0051567)2.57292118
51cell proliferation in forebrain (GO:0021846)2.56785980
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.56527517
53calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55962846
54regulation of mRNA splicing, via spliceosome (GO:0048024)2.54614179
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54157430
56behavioral response to ethanol (GO:0048149)2.53407952
57protein localization to synapse (GO:0035418)2.52894360
58histone H2A acetylation (GO:0043968)2.52761990
59spinal cord development (GO:0021510)2.52491983
60regulation of cilium movement (GO:0003352)2.51730238
61cilium morphogenesis (GO:0060271)2.47540761
62negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47227083
63somite development (GO:0061053)2.46262101
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45899271
65positive regulation of catecholamine secretion (GO:0033605)2.44683435
66synaptic vesicle maturation (GO:0016188)2.44642335
67centriole assembly (GO:0098534)2.44460569
68cilium movement (GO:0003341)2.44292447
69synapse assembly (GO:0007416)2.42968793
70positive regulation of synapse assembly (GO:0051965)2.42390227
71cardiac chamber formation (GO:0003207)2.40760692
72ubiquinone biosynthetic process (GO:0006744)2.39200344
73spermatid nucleus differentiation (GO:0007289)2.38629355
74negative regulation of oligodendrocyte differentiation (GO:0048715)2.38578572
75retinal ganglion cell axon guidance (GO:0031290)2.37798677
76isoprenoid biosynthetic process (GO:0008299)2.36184082
77microtubule depolymerization (GO:0007019)2.35919004
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.35705288
79regulation of translation, ncRNA-mediated (GO:0045974)2.35705288
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35705288
81positive regulation of dendritic spine morphogenesis (GO:0061003)2.35117291
82central nervous system projection neuron axonogenesis (GO:0021952)2.34927589
83regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.34918928
84neurotransmitter-gated ion channel clustering (GO:0072578)2.34427155
85regulation of synaptic vesicle transport (GO:1902803)2.33100383
86regulation of telomere maintenance (GO:0032204)2.33042483
87mRNA cleavage (GO:0006379)2.32675505
88protein polyglutamylation (GO:0018095)2.31837950
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.31544754
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.31514999
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.31514999
92smoothened signaling pathway (GO:0007224)2.31146282
93glial cell proliferation (GO:0014009)2.31068816
94regulation of meiosis I (GO:0060631)2.28163580
95regulation of autophagic vacuole assembly (GO:2000785)2.27382714
96regulation of helicase activity (GO:0051095)2.27331132
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.26997532
98substrate-independent telencephalic tangential migration (GO:0021826)2.26997532
99mRNA splice site selection (GO:0006376)2.26890704
100cell differentiation in spinal cord (GO:0021515)2.26544948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.72926622
2EZH2_22144423_ChIP-Seq_EOC_Human4.28267519
3IGF1R_20145208_ChIP-Seq_DFB_Human3.87373466
4ZNF274_21170338_ChIP-Seq_K562_Hela3.22789024
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20869944
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.17954150
7GBX2_23144817_ChIP-Seq_PC3_Human3.04489601
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76639072
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35101745
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29323926
11FUS_26573619_Chip-Seq_HEK293_Human2.28571220
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25965157
13* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20595782
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09576435
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.09067338
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08552091
17EWS_26573619_Chip-Seq_HEK293_Human2.07738071
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06304858
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05414541
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04728997
21VDR_22108803_ChIP-Seq_LS180_Human1.90364875
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89250671
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.84701156
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.79297189
25IRF1_19129219_ChIP-ChIP_H3396_Human1.78505578
26P300_19829295_ChIP-Seq_ESCs_Human1.70320830
27* GABP_17652178_ChIP-ChIP_JURKAT_Human1.64417434
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64125083
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64095078
30TAF15_26573619_Chip-Seq_HEK293_Human1.62568282
31RNF2_27304074_Chip-Seq_NSC_Mouse1.60389163
32REST_21632747_ChIP-Seq_MESCs_Mouse1.54548183
33CBP_20019798_ChIP-Seq_JUKART_Human1.47531967
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47531967
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.47447463
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47276099
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.46080922
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42938621
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42795479
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39323378
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39068499
42SMAD4_21799915_ChIP-Seq_A2780_Human1.36809241
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.36120685
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35830914
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35830914
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35054810
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34943783
48MYC_18940864_ChIP-ChIP_HL60_Human1.34208836
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32855962
50ELK1_19687146_ChIP-ChIP_HELA_Human1.32126972
51AR_21572438_ChIP-Seq_LNCaP_Human1.31893047
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29577627
53ER_23166858_ChIP-Seq_MCF-7_Human1.29269664
54* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28832329
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25125907
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24988971
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.24225784
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22236862
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19845731
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18043244
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17215106
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16595990
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16480806
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16419645
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16297018
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16117209
67VDR_23849224_ChIP-Seq_CD4+_Human1.15189280
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14700485
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10685674
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.10424442
71STAT3_23295773_ChIP-Seq_U87_Human1.09049789
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08459559
73RUNX2_22187159_ChIP-Seq_PCA_Human1.08231601
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.07458668
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.07185874
76SOX9_26525672_Chip-Seq_HEART_Mouse1.06278073
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.03888370
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03104770
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01151264
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.00209899
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97574684
82FOXP3_21729870_ChIP-Seq_TREG_Human0.97197942
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96148926
84AR_25329375_ChIP-Seq_VCAP_Human0.95407573
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95225073
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92278582
87* TCF4_23295773_ChIP-Seq_U87_Human0.90978301
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90976617
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89677092
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89423042
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89301729
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87358558
93E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87332369
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86577482
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.86456883
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86378513
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86327578
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85881217
99GABP_19822575_ChIP-Seq_HepG2_Human0.85338755
100BCAT_22108803_ChIP-Seq_LS180_Human0.84792725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.33695706
2MP0005394_taste/olfaction_phenotype3.20256132
3MP0005499_abnormal_olfactory_system3.20256132
4MP0003787_abnormal_imprinting2.98416879
5MP0001529_abnormal_vocalization2.81427567
6MP0008789_abnormal_olfactory_epithelium2.80795732
7MP0003121_genomic_imprinting2.72751030
8MP0003880_abnormal_central_pattern2.51854915
9MP0006276_abnormal_autonomic_nervous2.51432143
10MP0001984_abnormal_olfaction2.48178661
11MP0008877_abnormal_DNA_methylation2.15757460
12MP0004859_abnormal_synaptic_plasticity2.12604290
13MP0000778_abnormal_nervous_system2.09777801
14MP0002102_abnormal_ear_morphology2.07734708
15MP0006072_abnormal_retinal_apoptosis2.04028796
16MP0002638_abnormal_pupillary_reflex2.02104501
17MP0002653_abnormal_ependyma_morphology1.89666266
18MP0001188_hyperpigmentation1.83898720
19MP0006292_abnormal_olfactory_placode1.83202575
20MP0008058_abnormal_DNA_repair1.82679170
21MP0003635_abnormal_synaptic_transmissio1.72324230
22MP0005253_abnormal_eye_physiology1.70515618
23MP0009046_muscle_twitch1.68882388
24MP0002751_abnormal_autonomic_nervous1.66483849
25MP0000049_abnormal_middle_ear1.65732181
26MP0002735_abnormal_chemical_nociception1.60923208
27MP0002184_abnormal_innervation1.54576229
28MP0004811_abnormal_neuron_physiology1.52233083
29MP0004270_analgesia1.51050589
30MP0001968_abnormal_touch/_nociception1.49910564
31MP0002063_abnormal_learning/memory/cond1.48932060
32MP0002233_abnormal_nose_morphology1.47732094
33MP0003136_yellow_coat_color1.47605516
34MP0000955_abnormal_spinal_cord1.42301238
35MP0001502_abnormal_circadian_rhythm1.41287823
36MP0002572_abnormal_emotion/affect_behav1.40202510
37MP0002272_abnormal_nervous_system1.39135362
38MP0005187_abnormal_penis_morphology1.38735460
39MP0002557_abnormal_social/conspecific_i1.37413306
40MP0000631_abnormal_neuroendocrine_gland1.35709348
41MP0004133_heterotaxia1.34939763
42MP0003385_abnormal_body_wall1.30748973
43MP0009745_abnormal_behavioral_response1.29786726
44MP0002882_abnormal_neuron_morphology1.26656879
45MP0002822_catalepsy1.24844757
46MP0010094_abnormal_chromosome_stability1.22675658
47MP0003123_paternal_imprinting1.22357053
48MP0002752_abnormal_somatic_nervous1.22045120
49MP0002736_abnormal_nociception_after1.21392989
50MP0001486_abnormal_startle_reflex1.19992484
51MP0008995_early_reproductive_senescence1.18063703
52MP0003861_abnormal_nervous_system1.17191992
53MP0002064_seizures1.15140588
54MP0005391_vision/eye_phenotype1.14250300
55MP0002734_abnormal_mechanical_nocicepti1.12586814
56MP0002152_abnormal_brain_morphology1.11763074
57MP0003567_abnormal_fetal_cardiomyocyte1.11448996
58MP0003315_abnormal_perineum_morphology1.11230564
59MP0003938_abnormal_ear_development1.10911708
60MP0009697_abnormal_copulation1.10764078
61MP0005551_abnormal_eye_electrophysiolog1.08625409
62MP0003698_abnormal_male_reproductive1.08476480
63MP0002067_abnormal_sensory_capabilities1.08137430
64MP0001293_anophthalmia1.07367402
65MP0003119_abnormal_digestive_system1.06201765
66MP0002234_abnormal_pharynx_morphology1.05853569
67MP0005646_abnormal_pituitary_gland1.04795321
68MP0004924_abnormal_behavior1.03999184
69MP0005386_behavior/neurological_phenoty1.03999184
70MP0000566_synostosis1.03528302
71MP0008057_abnormal_DNA_replication0.95959485
72MP0001485_abnormal_pinna_reflex0.95628852
73MP0001929_abnormal_gametogenesis0.94777462
74MP0003937_abnormal_limbs/digits/tail_de0.94318402
75MP0002160_abnormal_reproductive_system0.93472969
76MP0003890_abnormal_embryonic-extraembry0.91340063
77MP0001970_abnormal_pain_threshold0.91188290
78MP0001299_abnormal_eye_distance/0.90959359
79MP0003755_abnormal_palate_morphology0.90177608
80MP0004142_abnormal_muscle_tone0.89661758
81MP0004885_abnormal_endolymph0.88673186
82MP0005195_abnormal_posterior_eye0.87257561
83MP0005423_abnormal_somatic_nervous0.84420247
84MP0000026_abnormal_inner_ear0.83410342
85MP0001286_abnormal_eye_development0.82138143
86MP0001270_distended_abdomen0.82005273
87MP0002210_abnormal_sex_determination0.80303039
88MP0002066_abnormal_motor_capabilities/c0.78395798
89MP0000653_abnormal_sex_gland0.77975749
90MP0000537_abnormal_urethra_morphology0.76938298
91MP0003935_abnormal_craniofacial_develop0.76795377
92MP0004145_abnormal_muscle_electrophysio0.76667418
93MP0002938_white_spotting0.76257643
94MP0002069_abnormal_eating/drinking_beha0.76008751
95MP0001145_abnormal_male_reproductive0.75491709
96MP0001986_abnormal_taste_sensitivity0.75192576
97MP0004742_abnormal_vestibular_system0.74751778
98MP0002733_abnormal_thermal_nociception0.73978941
99MP0008775_abnormal_heart_ventricle0.73620608
100MP0002081_perinatal_lethality0.73337424

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.44838021
2Gait imbalance (HP:0002141)3.42266822
3Abnormality of the labia minora (HP:0012880)3.27879437
4Nephrogenic diabetes insipidus (HP:0009806)3.18634589
5Pancreatic fibrosis (HP:0100732)3.17881745
6Medial flaring of the eyebrow (HP:0010747)3.16966778
7Congenital primary aphakia (HP:0007707)3.15769567
8Retinal dysplasia (HP:0007973)3.06844642
9Lissencephaly (HP:0001339)2.77708842
10Pancreatic cysts (HP:0001737)2.74970382
11Drooling (HP:0002307)2.71921524
12True hermaphroditism (HP:0010459)2.71357373
13Genital tract atresia (HP:0001827)2.70776117
14Pachygyria (HP:0001302)2.66239610
15Vaginal atresia (HP:0000148)2.58990336
16Poor coordination (HP:0002370)2.55768039
17Hepatoblastoma (HP:0002884)2.51441090
18Volvulus (HP:0002580)2.49896021
19High anterior hairline (HP:0009890)2.48097207
20Excessive salivation (HP:0003781)2.46931534
21Atonic seizures (HP:0010819)2.42070883
22Postaxial hand polydactyly (HP:0001162)2.39559139
23Nephronophthisis (HP:0000090)2.35155869
24Facial hemangioma (HP:0000329)2.30043939
25Abnormality of midbrain morphology (HP:0002418)2.29462683
26Molar tooth sign on MRI (HP:0002419)2.29462683
27Polyphagia (HP:0002591)2.26191201
28Broad alveolar ridges (HP:0000187)2.23634010
29Type II lissencephaly (HP:0007260)2.23487070
30Abnormal hair whorl (HP:0010721)2.22829743
31Postaxial foot polydactyly (HP:0001830)2.22028307
32Hyperglycinemia (HP:0002154)2.21186413
33Intestinal atresia (HP:0011100)2.19927556
34Chronic hepatic failure (HP:0100626)2.14593861
35Limb dystonia (HP:0002451)2.12811585
36Tubulointerstitial nephritis (HP:0001970)2.09384003
37Protruding tongue (HP:0010808)2.08787706
38Oligodactyly (hands) (HP:0001180)2.08165589
39Hypoplastic pelvis (HP:0008839)2.07268229
40Specific learning disability (HP:0001328)2.04297454
41Occipital encephalocele (HP:0002085)2.00693690
42Anencephaly (HP:0002323)1.99682943
43Decreased testicular size (HP:0008734)1.99274452
44Abnormality of the ileum (HP:0001549)1.99183673
45Aplasia/Hypoplasia of the uvula (HP:0010293)1.98485203
46Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97212760
47Hypoplasia of the brainstem (HP:0002365)1.97212760
48Hypothermia (HP:0002045)1.96814217
49Abnormality of the renal medulla (HP:0100957)1.96709558
50Exotropia (HP:0000577)1.95643710
51Hyperventilation (HP:0002883)1.94055262
52Renal dysplasia (HP:0000110)1.94029090
53Cystic liver disease (HP:0006706)1.92557444
54Meckel diverticulum (HP:0002245)1.92407643
55Prominent nasal bridge (HP:0000426)1.92380124
56Sclerocornea (HP:0000647)1.90243010
57Median cleft lip (HP:0000161)1.90190052
58Micropenis (HP:0000054)1.88889433
59Abnormality of the lower motor neuron (HP:0002366)1.87917514
60Aganglionic megacolon (HP:0002251)1.87847701
61Preaxial hand polydactyly (HP:0001177)1.86814948
62Amyotrophic lateral sclerosis (HP:0007354)1.85627536
63Narrow forehead (HP:0000341)1.85334338
64Broad-based gait (HP:0002136)1.84954570
65Cerebellar dysplasia (HP:0007033)1.83950835
66Urinary urgency (HP:0000012)1.83664633
67Focal motor seizures (HP:0011153)1.83551485
68Optic nerve hypoplasia (HP:0000609)1.83547963
69Supernumerary spleens (HP:0009799)1.83476972
70Broad foot (HP:0001769)1.83327146
71Thyroid-stimulating hormone excess (HP:0002925)1.82830219
72Medulloblastoma (HP:0002885)1.80933125
73Abnormality of the columella (HP:0009929)1.80740947
74Cerebral hypomyelination (HP:0006808)1.80520036
75Renal hypoplasia (HP:0000089)1.77597313
76Short foot (HP:0001773)1.77440672
77Absent speech (HP:0001344)1.75360987
78Focal seizures (HP:0007359)1.75079923
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.74771074
80Failure to thrive in infancy (HP:0001531)1.74352378
81Rimmed vacuoles (HP:0003805)1.73799870
82Patellar aplasia (HP:0006443)1.72995730
83Aplasia/Hypoplasia of the lens (HP:0008063)1.72619291
84Sloping forehead (HP:0000340)1.72023939
85Dandy-Walker malformation (HP:0001305)1.71794667
86Colon cancer (HP:0003003)1.71561155
87Abnormality of chromosome stability (HP:0003220)1.71525386
88Long clavicles (HP:0000890)1.71471340
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69878897
90Abolished electroretinogram (ERG) (HP:0000550)1.68705670
91Male pseudohermaphroditism (HP:0000037)1.68525537
92CNS hypomyelination (HP:0003429)1.67019244
93Astigmatism (HP:0000483)1.66301959
94Growth hormone deficiency (HP:0000824)1.66175983
95Hypoplastic iliac wings (HP:0002866)1.64765528
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.64734548
97Gastrointestinal atresia (HP:0002589)1.64176778
98Oligodactyly (HP:0012165)1.62882001
99Polymicrogyria (HP:0002126)1.62217468
100Hypoplasia of the corpus callosum (HP:0002079)1.62008529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.58239903
2PINK13.48330369
3MAP2K73.22046597
4BCR3.17733661
5SRPK12.87772919
6MAP3K42.87622771
7CASK2.65781139
8TNIK2.51708796
9CSNK1G32.46960873
10WNK32.43683651
11CSNK1G22.25178802
12CSNK1A1L2.23110870
13DYRK22.17202428
14NEK22.15216745
15CSNK1G12.06679522
16NTRK21.89847569
17EPHA41.85391438
18MAPK131.84479909
19TRIM281.76351314
20EPHA31.73268106
21DYRK31.66711274
22MAP4K21.65980171
23BCKDK1.63809920
24LATS11.59121544
25CCNB11.56950588
26MINK11.51507413
27BMPR1B1.46188850
28NUAK11.45587962
29MARK31.45314752
30SIK21.41401948
31NTRK31.36095484
32ZAK1.32190789
33CDC71.22976191
34CDK31.14180647
35RPS6KA41.12306496
36FRK1.11365981
37FGFR21.07245716
38PLK41.05319986
39MKNK11.03825644
40SGK2231.02694809
41SGK4941.02694809
42VRK10.93692028
43ERBB30.92923911
44PAK30.81274186
45CDK140.79825486
46CDK50.79482010
47PLK30.74960564
48PRKCG0.73102076
49PLK10.72012888
50PLK20.71679081
51KSR10.71659209
52RPS6KB10.71335813
53STK38L0.70862557
54ATM0.69679035
55MKNK20.69214131
56SGK20.68596485
57PNCK0.68169001
58TAF10.62797555
59WEE10.59732141
60ADRBK20.59258958
61BRD40.58437131
62CAMK40.58303312
63MAP3K100.57622150
64ATR0.57100886
65UHMK10.56210070
66DYRK1A0.55338652
67CSNK1E0.54580805
68CSNK1A10.53740401
69CAMKK20.53138970
70MUSK0.51631700
71EIF2AK30.51549396
72RPS6KA50.50910964
73CDK180.49769391
74DYRK1B0.47333507
75MAP2K40.46487825
76TIE10.45677470
77CSNK1D0.45549315
78PRKAA10.45091116
79PKN10.45079184
80CDK150.44714555
81CAMK10.44550875
82NTRK10.41838158
83PRKCQ0.40373576
84MAP3K90.39921782
85AURKB0.39267831
86GRK10.38762583
87PAK60.37980302
88CDK11A0.37773632
89NLK0.36824385
90INSRR0.36360172
91CDK20.35965894
92CAMK1G0.35856086
93CDK10.34261558
94OBSCN0.33561913
95RAF10.33285776
96TSSK60.32946554
97CSNK2A20.32789521
98PRKDC0.31529047
99TYRO30.30759665
100PRKCE0.30044921

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.74226536
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.67875605
3Butanoate metabolism_Homo sapiens_hsa006502.33955088
4Olfactory transduction_Homo sapiens_hsa047402.28485955
5Non-homologous end-joining_Homo sapiens_hsa034502.23226842
6Fanconi anemia pathway_Homo sapiens_hsa034602.12140207
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08902023
8Phototransduction_Homo sapiens_hsa047442.08149853
9Basal transcription factors_Homo sapiens_hsa030222.07668430
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04518202
11RNA degradation_Homo sapiens_hsa030181.91966839
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84922041
13Propanoate metabolism_Homo sapiens_hsa006401.83831683
14Steroid biosynthesis_Homo sapiens_hsa001001.81094072
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74762439
16Taste transduction_Homo sapiens_hsa047421.73514947
17GABAergic synapse_Homo sapiens_hsa047271.73437428
18Spliceosome_Homo sapiens_hsa030401.63079024
19Protein export_Homo sapiens_hsa030601.62407994
20Circadian entrainment_Homo sapiens_hsa047131.54918332
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54116358
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53132408
23mRNA surveillance pathway_Homo sapiens_hsa030151.41067272
24Hedgehog signaling pathway_Homo sapiens_hsa043401.40712612
25RNA transport_Homo sapiens_hsa030131.35825691
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35470480
27Oocyte meiosis_Homo sapiens_hsa041141.34684331
28Axon guidance_Homo sapiens_hsa043601.32582271
29Parkinsons disease_Homo sapiens_hsa050121.32522181
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32230927
31Mismatch repair_Homo sapiens_hsa034301.32181420
32RNA polymerase_Homo sapiens_hsa030201.31965502
33Dopaminergic synapse_Homo sapiens_hsa047281.31173439
34Homologous recombination_Homo sapiens_hsa034401.30430109
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27813562
36Oxidative phosphorylation_Homo sapiens_hsa001901.27205957
37Cocaine addiction_Homo sapiens_hsa050301.25660164
38Alcoholism_Homo sapiens_hsa050341.22909724
39DNA replication_Homo sapiens_hsa030301.21312903
40Morphine addiction_Homo sapiens_hsa050321.19110742
41Glutamatergic synapse_Homo sapiens_hsa047241.16605900
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16372979
43Base excision repair_Homo sapiens_hsa034101.13969325
44Synaptic vesicle cycle_Homo sapiens_hsa047211.13154670
45Gap junction_Homo sapiens_hsa045401.11535921
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11301052
47Nucleotide excision repair_Homo sapiens_hsa034201.09148201
48Amphetamine addiction_Homo sapiens_hsa050311.09089010
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06693582
50Circadian rhythm_Homo sapiens_hsa047101.05421697
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02410484
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00242797
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98745139
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97285536
55Selenocompound metabolism_Homo sapiens_hsa004500.96456535
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94163789
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93300553
58Basal cell carcinoma_Homo sapiens_hsa052170.92470193
59Purine metabolism_Homo sapiens_hsa002300.90543918
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85552249
61Huntingtons disease_Homo sapiens_hsa050160.85370591
62Long-term depression_Homo sapiens_hsa047300.85154277
63Regulation of autophagy_Homo sapiens_hsa041400.84634463
64Cell cycle_Homo sapiens_hsa041100.83081945
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82985619
66Cardiac muscle contraction_Homo sapiens_hsa042600.82640803
67Pyrimidine metabolism_Homo sapiens_hsa002400.82419178
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80246983
69Wnt signaling pathway_Homo sapiens_hsa043100.79566364
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78982728
71Alzheimers disease_Homo sapiens_hsa050100.77533052
72Oxytocin signaling pathway_Homo sapiens_hsa049210.74153482
73Peroxisome_Homo sapiens_hsa041460.72596234
74Collecting duct acid secretion_Homo sapiens_hsa049660.70212950
75Cholinergic synapse_Homo sapiens_hsa047250.68118395
76Pyruvate metabolism_Homo sapiens_hsa006200.67854997
77Hippo signaling pathway_Homo sapiens_hsa043900.67212379
78Lysine degradation_Homo sapiens_hsa003100.67000141
79Salivary secretion_Homo sapiens_hsa049700.66880227
80beta-Alanine metabolism_Homo sapiens_hsa004100.65278913
81Fatty acid elongation_Homo sapiens_hsa000620.61938981
82Serotonergic synapse_Homo sapiens_hsa047260.61013018
83Biosynthesis of amino acids_Homo sapiens_hsa012300.57665886
84Nitrogen metabolism_Homo sapiens_hsa009100.55467125
85Fatty acid metabolism_Homo sapiens_hsa012120.54622534
86Melanogenesis_Homo sapiens_hsa049160.52249515
87Insulin secretion_Homo sapiens_hsa049110.52097604
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50081983
89Renin secretion_Homo sapiens_hsa049240.48547629
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48028627
91Metabolic pathways_Homo sapiens_hsa011000.47115483
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45693555
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44799426
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.44052290
95AMPK signaling pathway_Homo sapiens_hsa041520.42528602
96Calcium signaling pathway_Homo sapiens_hsa040200.42440752
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41027639
98Gastric acid secretion_Homo sapiens_hsa049710.38063268
99TGF-beta signaling pathway_Homo sapiens_hsa043500.37284754
100Type II diabetes mellitus_Homo sapiens_hsa049300.36897518

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »