ZNF503

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)9.48237683
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.96327264
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.70693848
4regulation of apoptotic process involved in morphogenesis (GO:1902337)5.67376628
5outer ear morphogenesis (GO:0042473)5.61447108
6embryonic heart tube development (GO:0035050)5.60876700
7mammary gland epithelial cell differentiation (GO:0060644)5.49140186
8cardiac muscle cell proliferation (GO:0060038)5.24706315
9regulation of mammary gland epithelial cell proliferation (GO:0033599)5.17490269
10negative regulation of homotypic cell-cell adhesion (GO:0034111)4.96160707
11cranial nerve morphogenesis (GO:0021602)4.95356334
12embryonic skeletal joint morphogenesis (GO:0060272)4.90022416
13ribosomal small subunit biogenesis (GO:0042274)4.89206491
14regulation of heart morphogenesis (GO:2000826)4.66712331
15thyroid gland development (GO:0030878)4.54929196
16outflow tract septum morphogenesis (GO:0003148)4.52191867
17striated muscle cell proliferation (GO:0014855)4.49393403
18maturation of SSU-rRNA (GO:0030490)4.29796032
19tooth mineralization (GO:0034505)4.29316837
20regulation of mesenchymal cell apoptotic process (GO:2001053)4.28775362
21viral transcription (GO:0019083)4.27331058
22cochlea morphogenesis (GO:0090103)4.18030383
23proximal/distal pattern formation (GO:0009954)4.14803868
24branching involved in prostate gland morphogenesis (GO:0060442)4.13400068
25kidney mesenchyme development (GO:0072074)4.11794689
26heart trabecula formation (GO:0060347)4.06696414
27regulation of cardioblast differentiation (GO:0051890)4.05916181
28translational termination (GO:0006415)4.04487494
29epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.00420198
30muscle cell fate commitment (GO:0042693)4.00283064
31middle ear morphogenesis (GO:0042474)3.96685042
32dorsal/ventral neural tube patterning (GO:0021904)3.93724277
33neuron fate specification (GO:0048665)3.91718318
34muscle cell proliferation (GO:0033002)3.89643137
35regulation of chromatin binding (GO:0035561)3.82916340
36germ cell migration (GO:0008354)3.80080973
37ventricular septum morphogenesis (GO:0060412)3.78266574
38embryonic skeletal system morphogenesis (GO:0048704)3.76634312
39cartilage morphogenesis (GO:0060536)3.70247613
40ventricular trabecula myocardium morphogenesis (GO:0003222)3.69983822
41neural crest cell development (GO:0014032)3.67342938
42planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65592060
43embryonic forelimb morphogenesis (GO:0035115)3.64423183
44regulation of cardioblast proliferation (GO:0003264)3.55071915
45regulation of secondary heart field cardioblast proliferation (GO:0003266)3.55071915
46regulation of organ formation (GO:0003156)3.51226576
47endocardial cushion morphogenesis (GO:0003203)3.47055205
48heterochromatin organization (GO:0070828)3.46442678
49aorta morphogenesis (GO:0035909)3.40318781
50organ induction (GO:0001759)3.40268282
51cardiac septum morphogenesis (GO:0060411)3.36709092
52trabecula formation (GO:0060343)3.36032041
53positive regulation of gastrulation (GO:2000543)3.32373474
54diaphragm development (GO:0060539)3.32141161
55respiratory tube development (GO:0030323)3.31621280
56peripheral nervous system neuron development (GO:0048935)3.30874422
57forelimb morphogenesis (GO:0035136)3.30673555
58mesenchymal-epithelial cell signaling (GO:0060638)3.25717330
59translational elongation (GO:0006414)3.25716666
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.25456455
61mesenchyme morphogenesis (GO:0072132)3.25384544
62mesenchymal cell development (GO:0014031)3.25376297
63artery morphogenesis (GO:0048844)3.25303431
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23164672
65cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.20940360
66skeletal muscle organ development (GO:0060538)3.17691723
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16740768
68positive regulation of hair follicle development (GO:0051798)3.12179060
69positive regulation of hair cycle (GO:0042635)3.12179060
70cotranslational protein targeting to membrane (GO:0006613)3.11801039
71lung-associated mesenchyme development (GO:0060484)3.09805965
72pattern specification involved in kidney development (GO:0061004)3.09478527
73protein targeting to ER (GO:0045047)3.08867549
74skeletal system morphogenesis (GO:0048705)3.08376546
75regulation of NFAT protein import into nucleus (GO:0051532)3.07512354
76cellular protein complex disassembly (GO:0043624)3.07357296
77negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.04758142
78embryonic organ morphogenesis (GO:0048562)3.01692262
79atrial septum morphogenesis (GO:0060413)3.01305671
80anterior/posterior pattern specification (GO:0009952)3.01042939
81heart trabecula morphogenesis (GO:0061384)3.00284814
82establishment of planar polarity (GO:0001736)2.97268887
83establishment of tissue polarity (GO:0007164)2.97268887
84viral life cycle (GO:0019058)2.96973199
85protein localization to microtubule (GO:0035372)2.96391837
86midbrain development (GO:0030901)2.95727824
87axis elongation (GO:0003401)2.94589452
88establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92237017
89regulation of hair follicle development (GO:0051797)2.91534814
90Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90576899
91branch elongation of an epithelium (GO:0060602)2.89180236
92urogenital system development (GO:0001655)2.88977396
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.85658364
94coronary vasculature morphogenesis (GO:0060977)2.85173917
95embryonic cranial skeleton morphogenesis (GO:0048701)2.83679464
96convergent extension (GO:0060026)2.83540371
97pharyngeal system development (GO:0060037)2.77666160
98stem cell development (GO:0048864)2.76823424
99protein localization to endoplasmic reticulum (GO:0070972)2.76155924
100protein complex disassembly (GO:0043241)2.75752210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_19390658_ChIP-ChIP_HaCaT_Human3.77114374
2PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.66549761
3CBX2_27304074_Chip-Seq_ESCs_Mouse3.66287795
4EED_16625203_ChIP-ChIP_MESCs_Mouse3.62362792
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.57592285
6TP53_20018659_ChIP-ChIP_R1E_Mouse3.32794360
7RNF2_18974828_ChIP-Seq_MESCs_Mouse3.00595453
8EZH2_18974828_ChIP-Seq_MESCs_Mouse3.00595453
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85756176
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85478078
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.59693619
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54535967
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.51150836
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50209865
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.41500023
16XRN2_22483619_ChIP-Seq_HELA_Human2.40005333
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28656032
18RING1B_27294783_Chip-Seq_NPCs_Mouse2.11525481
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08300627
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.06099212
21KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.05868726
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03526301
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.02409931
24RNF2_27304074_Chip-Seq_NSC_Mouse1.96795806
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.94394330
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89364714
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85100137
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84576741
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83184157
30TTF2_22483619_ChIP-Seq_HELA_Human1.80221110
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77845150
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76757511
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.72738933
34LXR_22292898_ChIP-Seq_THP-1_Human1.72554714
35* KDM2B_26808549_Chip-Seq_K562_Human1.71678809
36VDR_21846776_ChIP-Seq_THP-1_Human1.71552031
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.71342457
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69152143
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.67253851
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66811752
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65677003
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.64655964
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.62968234
44STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.60244262
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58284678
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51827082
47RACK7_27058665_Chip-Seq_MCF-7_Human1.49090810
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48937514
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48034856
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46226574
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45014013
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42846655
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42188719
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42188719
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42188719
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38472009
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38178107
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37805543
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.37145085
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.36924601
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33035985
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32037639
63* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29287077
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26769439
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26634580
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25165957
67KDM2B_26808549_Chip-Seq_DND41_Human1.24595397
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19239870
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19126217
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18938782
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15108624
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.14789082
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13386060
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13248460
75MYC_22102868_ChIP-Seq_BL_Human1.12796868
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.12409291
77* CREB1_26743006_Chip-Seq_LNCaP_Human1.08931246
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08589905
79E2F7_22180533_ChIP-Seq_HELA_Human1.07934792
80AR_21909140_ChIP-Seq_LNCAP_Human1.07560447
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07487431
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07432892
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07323074
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06413691
85* CTCF_27219007_Chip-Seq_Bcells_Human1.05155842
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04327023
87* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03096372
88SOX3_22085726_ChIP-Seq_NPCs_Mouse1.00787399
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99742094
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99188337
91ZNF263_19887448_ChIP-Seq_K562_Human0.99003836
92* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96996400
93* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95872960
94P68_20966046_ChIP-Seq_HELA_Human0.95667043
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95567136
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95497393
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93627916
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93399739
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91991554
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91971282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology5.19348664
2MP0001346_abnormal_lacrimal_gland4.86994981
3MP0002249_abnormal_larynx_morphology4.47689047
4MP0009053_abnormal_anal_canal3.60464824
5MP0010030_abnormal_orbit_morphology3.42995280
6MP0000566_synostosis3.38299669
7MP0002234_abnormal_pharynx_morphology3.18151369
8MP0000537_abnormal_urethra_morphology3.03039110
9MP0005367_renal/urinary_system_phenotyp2.90604638
10MP0000516_abnormal_urinary_system2.90604638
11MP0009250_abnormal_appendicular_skeleto2.82191112
12MP0000049_abnormal_middle_ear2.72743454
13MP0003942_abnormal_urinary_system2.42801136
14MP0002282_abnormal_trachea_morphology2.21817974
15MP0004272_abnormal_basement_membrane2.18381256
16MP0000534_abnormal_ureter_morphology2.18114408
17MP0003283_abnormal_digestive_organ2.13096621
18MP0005187_abnormal_penis_morphology2.09303763
19MP0000678_abnormal_parathyroid_gland2.07688711
20MP0005503_abnormal_tendon_morphology2.03837985
21MP0002697_abnormal_eye_size1.99208861
22MP0003937_abnormal_limbs/digits/tail_de1.88214021
23MP0009379_abnormal_foot_pigmentation1.82305223
24MP0003315_abnormal_perineum_morphology1.74780146
25MP0002932_abnormal_joint_morphology1.72340725
26MP0005508_abnormal_skeleton_morphology1.59772731
27MP0001879_abnormal_lymphatic_vessel1.59207022
28MP0002160_abnormal_reproductive_system1.58569197
29MP0003938_abnormal_ear_development1.52800528
30MP0000681_abnormal_thyroid_gland1.50328686
31MP0000733_abnormal_muscle_development1.47092355
32MP0002092_abnormal_eye_morphology1.43747684
33MP0002938_white_spotting1.40631034
34MP0002098_abnormal_vibrissa_morphology1.39460843
35MP0002116_abnormal_craniofacial_bone1.39050302
36MP0008438_abnormal_cutaneous_collagen1.37159469
37MP0003755_abnormal_palate_morphology1.36281343
38MP0003705_abnormal_hypodermis_morpholog1.36132799
39MP0000762_abnormal_tongue_morphology1.35613432
40MP0003935_abnormal_craniofacial_develop1.32721926
41MP0001286_abnormal_eye_development1.29348405
42MP0002233_abnormal_nose_morphology1.27780060
43MP0003385_abnormal_body_wall1.27426881
44MP0001270_distended_abdomen1.26351339
45MP0005076_abnormal_cell_differentiation1.25397413
46MP0000579_abnormal_nail_morphology1.24068663
47MP0002114_abnormal_axial_skeleton1.16487356
48MP0000428_abnormal_craniofacial_morphol1.12859486
49MP0008961_abnormal_basal_metabolism1.11620393
50MP0006292_abnormal_olfactory_placode1.10842130
51MP0001188_hyperpigmentation1.10115580
52MP0004858_abnormal_nervous_system1.09897227
53MP0000631_abnormal_neuroendocrine_gland1.09637343
54MP0002277_abnormal_respiratory_mucosa1.08681106
55MP0005197_abnormal_uvea_morphology1.08645822
56MP0002177_abnormal_outer_ear1.06312914
57MP0003279_aneurysm1.04710922
58MP0000003_abnormal_adipose_tissue1.03264354
59MP0000163_abnormal_cartilage_morphology0.96314628
60MP0002085_abnormal_embryonic_tissue0.96131174
61MP0008932_abnormal_embryonic_tissue0.95648322
62MP0003861_abnormal_nervous_system0.95506470
63MP0005409_darkened_coat_color0.94938160
64MP0010368_abnormal_lymphatic_system0.93282289
65MP0000432_abnormal_head_morphology0.92990924
66MP0003115_abnormal_respiratory_system0.92105792
67MP0002111_abnormal_tail_morphology0.91240879
68MP0003119_abnormal_digestive_system0.90840259
69MP0002877_abnormal_melanocyte_morpholog0.90506945
70MP0000767_abnormal_smooth_muscle0.90316143
71MP0001340_abnormal_eyelid_morphology0.89633770
72MP0000778_abnormal_nervous_system0.89534554
73MP0002108_abnormal_muscle_morphology0.89389901
74MP0002109_abnormal_limb_morphology0.85256405
75MP0002163_abnormal_gland_morphology0.83121367
76MP0002115_abnormal_skeleton_extremities0.82760075
77MP0001293_anophthalmia0.82485821
78MP0005275_abnormal_skin_tensile0.82447083
79MP0003693_abnormal_embryo_hatching0.82310921
80MP0001324_abnormal_eye_pigmentation0.82171674
81MP0003077_abnormal_cell_cycle0.79539516
82MP0003136_yellow_coat_color0.78994356
83MP0000462_abnormal_digestive_system0.76763950
84MP0000467_abnormal_esophagus_morphology0.75658496
85MP0002081_perinatal_lethality0.73888910
86MP0002113_abnormal_skeleton_development0.73026284
87MP0002084_abnormal_developmental_patter0.72964843
88MP0005670_abnormal_white_adipose0.71475648
89MP0003111_abnormal_nucleus_morphology0.70717361
90MP0000350_abnormal_cell_proliferation0.69340277
91MP0001299_abnormal_eye_distance/0.69090593
92MP0005646_abnormal_pituitary_gland0.68724792
93MP0001502_abnormal_circadian_rhythm0.67482610
94MP0003091_abnormal_cell_migration0.66594735
95MP0002089_abnormal_postnatal_growth/wei0.66067548
96MP0000026_abnormal_inner_ear0.64781819
97MP0004782_abnormal_surfactant_physiolog0.64609334
98MP0009384_cardiac_valve_regurgitation0.64326720
99MP0005257_abnormal_intraocular_pressure0.61595337
100MP0005375_adipose_tissue_phenotype0.61240396

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the phalanges of the hallux (HP:0010057)4.97719813
2Broad distal phalanx of finger (HP:0009836)4.51266765
3Abnormality of the fetal cardiovascular system (HP:0010948)4.35218830
4Abnormal umbilical cord blood vessels (HP:0011403)4.35218830
5Single umbilical artery (HP:0001195)4.35218830
6Congenital malformation of the right heart (HP:0011723)4.32179847
7Double outlet right ventricle (HP:0001719)4.32179847
8Ulnar bowing (HP:0003031)4.18272282
9Septate vagina (HP:0001153)4.15823209
10Transposition of the great arteries (HP:0001669)3.84968363
11Abnormal connection of the cardiac segments (HP:0011545)3.84968363
12Abnormal ventriculo-arterial connection (HP:0011563)3.84968363
13Abnormality of the aortic arch (HP:0012303)3.62526243
14Abnormality of the distal phalanx of the thumb (HP:0009617)3.61059470
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.44405543
16Partial duplication of the phalanx of hand (HP:0009999)3.43550404
17Short middle phalanx of the 5th finger (HP:0004220)3.35015649
18Hypoplastic left heart (HP:0004383)3.31211483
19Abnormality of the distal phalanges of the toes (HP:0010182)3.28087053
20Abnormality of the middle phalanges of the toes (HP:0010183)3.25945954
21Hypoplasia of the iris (HP:0007676)3.18581900
22Abnormality of the 4th metacarpal (HP:0010012)3.09009286
23Abnormality of the parietal bone (HP:0002696)3.07094032
24Partial duplication of thumb phalanx (HP:0009944)3.06243297
25Rectal fistula (HP:0100590)2.95678269
26Rectovaginal fistula (HP:0000143)2.95678269
27Preauricular pit (HP:0004467)2.95270006
28Periauricular skin pits (HP:0100277)2.95270006
29Abnormal number of incisors (HP:0011064)2.92913214
30Renal dysplasia (HP:0000110)2.92774143
31Esophageal atresia (HP:0002032)2.86375477
32Abnormality of the umbilical cord (HP:0010881)2.77899039
33Bowed forearm bones (HP:0003956)2.77432147
34Bowing of the arm (HP:0006488)2.77432147
35Abnormality of the anterior chamber (HP:0000593)2.76354182
36Intestinal fistula (HP:0100819)2.74059625
37Vaginal fistula (HP:0004320)2.69185959
38Preaxial foot polydactyly (HP:0001841)2.56071120
39Concave nail (HP:0001598)2.52129753
40Hypoplastic heart (HP:0001961)2.52094963
41Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.47471415
42Short 5th finger (HP:0009237)2.45413634
43Bifid scrotum (HP:0000048)2.43898804
44Midline defect of the nose (HP:0004122)2.41722926
45Coronal craniosynostosis (HP:0004440)2.40747569
46Deviation of the hallux (HP:0010051)2.34539140
47Breast hypoplasia (HP:0003187)2.30492344
48Absent phalangeal crease (HP:0006109)2.28677488
49Pulmonary artery stenosis (HP:0004415)2.28075074
50Aplasia/Hypoplasia of the clavicles (HP:0006710)2.22202449
51Unilateral renal agenesis (HP:0000122)2.21162494
52Skin pits (HP:0100276)2.19867526
53Hallux valgus (HP:0001822)2.19231563
54Cutaneous finger syndactyly (HP:0010554)2.19083494
55Broad thumb (HP:0011304)2.15404478
56Shallow orbits (HP:0000586)2.13794164
57Protrusio acetabuli (HP:0003179)2.13608077
58Nasolacrimal duct obstruction (HP:0000579)2.13206549
59Aplasia/Hypoplasia of the lens (HP:0008063)2.13037584
60Genu recurvatum (HP:0002816)2.12733445
61Abnormality of the intervertebral disk (HP:0005108)2.11677214
62Truncus arteriosus (HP:0001660)2.10237924
63Short clavicles (HP:0000894)2.09999494
64Broad metatarsal (HP:0001783)2.09854254
65Abnormal finger flexion creases (HP:0006143)2.07347485
66Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.07179886
67Carpal synostosis (HP:0009702)2.06663318
68Duplication of thumb phalanx (HP:0009942)2.01330728
69Symphalangism affecting the phalanges of the hand (HP:0009773)2.00904991
70Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98893980
71Radial bowing (HP:0002986)1.93946927
72Cutaneous syndactyly (HP:0012725)1.92401320
73High anterior hairline (HP:0009890)1.88595466
74Broad phalanges of the hand (HP:0009768)1.88466754
75Laryngomalacia (HP:0001601)1.88424009
76Abnormality of the radial head (HP:0003995)1.84181754
77Hypoplasia of the radius (HP:0002984)1.81956450
78Broad finger (HP:0001500)1.81818354
79Occipital encephalocele (HP:0002085)1.78859301
80Posterior embryotoxon (HP:0000627)1.78120018
81Anal stenosis (HP:0002025)1.77755782
82Birth length less than 3rd percentile (HP:0003561)1.76785573
83Turricephaly (HP:0000262)1.76278663
84Aplastic anemia (HP:0001915)1.76134858
85Abnormality of the 2nd finger (HP:0004100)1.76070772
86Abnormality of the nasolacrimal system (HP:0000614)1.75335967
87Short middle phalanx of finger (HP:0005819)1.74525342
88Abnormality of chromosome segregation (HP:0002916)1.73870851
89Aplasia/Hypoplasia of the patella (HP:0006498)1.71797910
90Abnormality of the lacrimal duct (HP:0011481)1.71528611
91Slender long bone (HP:0003100)1.70391303
92Broad phalanx (HP:0006009)1.70107135
93Broad hallux (HP:0010055)1.70035320
94Abnormality of the phalanges of the 5th finger (HP:0004213)1.68838210
95Dislocated radial head (HP:0003083)1.68102716
96Trigonocephaly (HP:0000243)1.67639568
97Aplasia involving forearm bones (HP:0009822)1.66924709
98Absent forearm bone (HP:0003953)1.66924709
99Synostosis involving bones of the hand (HP:0004278)1.66565513
100Reticulocytopenia (HP:0001896)1.66385201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.19784521
2CDK124.07981512
3EEF2K3.58450764
4SMG12.76187512
5MAPK152.60118838
6MAP3K102.59397583
7IRAK32.48970846
8IRAK22.37407555
9SIK12.35298586
10TRIB32.12954489
11BUB12.11124375
12PNCK2.07786150
13VRK22.03447107
14NME21.88880277
15DYRK31.75074952
16ICK1.68735319
17BRD41.62092079
18CAMK1G1.58156002
19DDR21.54964276
20LATS21.52907223
21TAOK11.43951210
22CHEK21.43139845
23CDK81.42274237
24KDR1.35122517
25DMPK1.31445443
26CDC71.28288487
27CAMK1D1.23195084
28EPHA21.23166311
29STK41.22894624
30PRKD31.19562433
31TRIM281.18213797
32MTOR1.15367418
33PRPF4B1.14308311
34HIPK21.13013818
35STK241.12458373
36MAP3K31.10290095
37RPS6KL11.06909258
38RPS6KC11.06909258
39CDK71.04672835
40FGFR21.03195273
41RPS6KA61.01420402
42MKNK20.99624691
43PIM20.97682252
44TAOK20.95885094
45RPS6KA20.93809543
46AKT20.90244817
47UHMK10.87792564
48WEE10.87057862
49AURKA0.84794051
50BRSK10.83963288
51PDGFRA0.81484658
52PLK40.79320420
53ILK0.78218460
54MKNK10.77747849
55PAK20.76396881
56TAF10.76144897
57CDK30.76085692
58CSNK1G30.74945283
59PRKD20.74541397
60ATR0.70093640
61CHUK0.69920596
62BRAF0.69120593
63IRAK10.67590991
64VRK10.67545790
65RPS6KA10.65577571
66AKT30.64598483
67CDK90.62977497
68CDK40.62848329
69GSK3A0.62129969
70ABL20.61343709
71CHEK10.58554106
72MAP3K20.55207881
73CDK20.54893630
74CSNK1G10.54747842
75STK160.53924370
76STK110.53795458
77CSNK1A1L0.52686894
78MAP2K20.51789602
79TYRO30.50524095
80LATS10.50470580
81PTK20.49260143
82LRRK20.48726085
83ARAF0.47273102
84IRAK40.44339447
85PRKAA10.43672525
86CSNK1G20.43509542
87AURKB0.42263062
88DYRK1B0.42000444
89EPHA40.40456199
90RIPK10.39790772
91AKT10.38778481
92NME10.38600591
93TTK0.37798785
94MAPK140.37663306
95CDK11A0.36846953
96DAPK30.35893270
97CSNK1E0.35225409
98CDK10.34823930
99MAPK80.34369564
100MAP3K80.32878607

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.84490972
2Basal cell carcinoma_Homo sapiens_hsa052173.84991375
3Sulfur relay system_Homo sapiens_hsa041223.57247663
4Hedgehog signaling pathway_Homo sapiens_hsa043403.39518576
5Notch signaling pathway_Homo sapiens_hsa043302.66633324
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.37712652
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.28225176
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.23212912
9Hippo signaling pathway_Homo sapiens_hsa043902.18053113
10Spliceosome_Homo sapiens_hsa030402.11545044
11Bladder cancer_Homo sapiens_hsa052192.09133074
12Wnt signaling pathway_Homo sapiens_hsa043102.04438761
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.84344210
14RNA polymerase_Homo sapiens_hsa030201.79364949
15Melanogenesis_Homo sapiens_hsa049161.63615950
16TGF-beta signaling pathway_Homo sapiens_hsa043501.61715092
17ECM-receptor interaction_Homo sapiens_hsa045121.54945822
18Vitamin B6 metabolism_Homo sapiens_hsa007501.54501278
19DNA replication_Homo sapiens_hsa030301.52058604
20Oxidative phosphorylation_Homo sapiens_hsa001901.48863692
21MicroRNAs in cancer_Homo sapiens_hsa052061.43871632
22Cell cycle_Homo sapiens_hsa041101.40610715
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28723359
24Huntingtons disease_Homo sapiens_hsa050161.27189838
25p53 signaling pathway_Homo sapiens_hsa041151.22589147
26Melanoma_Homo sapiens_hsa052181.20552884
27Axon guidance_Homo sapiens_hsa043601.18457443
28Parkinsons disease_Homo sapiens_hsa050121.13105890
29Chronic myeloid leukemia_Homo sapiens_hsa052201.12553446
30Prion diseases_Homo sapiens_hsa050201.09931872
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09541288
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08219900
33Pathways in cancer_Homo sapiens_hsa052001.06449054
34Prostate cancer_Homo sapiens_hsa052151.05073816
35Base excision repair_Homo sapiens_hsa034101.04947491
36Cocaine addiction_Homo sapiens_hsa050301.03247158
37Protein digestion and absorption_Homo sapiens_hsa049741.01004214
38Small cell lung cancer_Homo sapiens_hsa052220.98409486
39Phenylalanine metabolism_Homo sapiens_hsa003600.93996249
40HTLV-I infection_Homo sapiens_hsa051660.92501186
41Pyrimidine metabolism_Homo sapiens_hsa002400.92392681
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.92181359
43Alzheimers disease_Homo sapiens_hsa050100.91459865
44mRNA surveillance pathway_Homo sapiens_hsa030150.85854593
45RNA transport_Homo sapiens_hsa030130.84654573
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84046212
47AMPK signaling pathway_Homo sapiens_hsa041520.81192414
48Focal adhesion_Homo sapiens_hsa045100.80678955
49Lysine degradation_Homo sapiens_hsa003100.78584776
50Glioma_Homo sapiens_hsa052140.77073645
51Non-small cell lung cancer_Homo sapiens_hsa052230.75234729
52Pancreatic cancer_Homo sapiens_hsa052120.74050811
53Cardiac muscle contraction_Homo sapiens_hsa042600.73915814
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73869311
55Folate biosynthesis_Homo sapiens_hsa007900.73555649
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73363021
57Proteoglycans in cancer_Homo sapiens_hsa052050.72312733
58Renal cell carcinoma_Homo sapiens_hsa052110.71636502
59Circadian rhythm_Homo sapiens_hsa047100.68484448
60Colorectal cancer_Homo sapiens_hsa052100.68392408
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.68086546
62Basal transcription factors_Homo sapiens_hsa030220.66352702
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.64843888
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63492248
65Amphetamine addiction_Homo sapiens_hsa050310.63357223
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62833358
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61688533
68Gap junction_Homo sapiens_hsa045400.61507325
69Endometrial cancer_Homo sapiens_hsa052130.58388692
70FoxO signaling pathway_Homo sapiens_hsa040680.58228835
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55248113
72Estrogen signaling pathway_Homo sapiens_hsa049150.52827854
73MAPK signaling pathway_Homo sapiens_hsa040100.52507425
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49687992
75mTOR signaling pathway_Homo sapiens_hsa041500.48459041
76ErbB signaling pathway_Homo sapiens_hsa040120.47044754
77Homologous recombination_Homo sapiens_hsa034400.46807313
78Amoebiasis_Homo sapiens_hsa051460.45824201
79Thyroid cancer_Homo sapiens_hsa052160.45606965
80Adherens junction_Homo sapiens_hsa045200.45205731
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44348302
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43925622
83Vibrio cholerae infection_Homo sapiens_hsa051100.42572267
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41995576
85Choline metabolism in cancer_Homo sapiens_hsa052310.41675606
86Arginine and proline metabolism_Homo sapiens_hsa003300.41375503
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40424925
88Mismatch repair_Homo sapiens_hsa034300.39471204
89Purine metabolism_Homo sapiens_hsa002300.38107605
90GnRH signaling pathway_Homo sapiens_hsa049120.36626372
91One carbon pool by folate_Homo sapiens_hsa006700.35969781
92VEGF signaling pathway_Homo sapiens_hsa043700.34595633
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33715571
94Tyrosine metabolism_Homo sapiens_hsa003500.33388138
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32340382
96Rap1 signaling pathway_Homo sapiens_hsa040150.31705154
97Nucleotide excision repair_Homo sapiens_hsa034200.31372476
98Fanconi anemia pathway_Homo sapiens_hsa034600.27713834
99Insulin signaling pathway_Homo sapiens_hsa049100.26144364
100Glucagon signaling pathway_Homo sapiens_hsa049220.25635729

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