ZNF502

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.67270645
2regulation of meiosis I (GO:0060631)4.64627878
3presynaptic membrane assembly (GO:0097105)4.19061021
4piRNA metabolic process (GO:0034587)4.15505743
5DNA double-strand break processing (GO:0000729)3.90858774
6somite rostral/caudal axis specification (GO:0032525)3.87915888
7synapsis (GO:0007129)3.85103550
8retinal cone cell development (GO:0046549)3.77652731
9peptidyl-histidine modification (GO:0018202)3.69713979
10presynaptic membrane organization (GO:0097090)3.58603197
11glycine transport (GO:0015816)3.53035739
12DNA methylation involved in gamete generation (GO:0043046)3.51138304
13positive regulation of meiosis (GO:0045836)3.46094775
14gamma-aminobutyric acid transport (GO:0015812)3.45595678
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39918067
16cilium morphogenesis (GO:0060271)3.31127735
17regulation of DNA methylation (GO:0044030)3.28322941
18cullin deneddylation (GO:0010388)3.27418220
19nonmotile primary cilium assembly (GO:0035058)3.25768894
20male meiosis (GO:0007140)3.25411886
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23207682
22somatic hypermutation of immunoglobulin genes (GO:0016446)3.23207682
23positive regulation of meiotic cell cycle (GO:0051446)3.19662480
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16398222
25intraciliary transport (GO:0042073)3.16028288
26negative regulation of transcription regulatory region DNA binding (GO:2000678)3.12028034
27neural tube formation (GO:0001841)3.06762854
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05639065
29water-soluble vitamin biosynthetic process (GO:0042364)3.00203760
30protein-cofactor linkage (GO:0018065)2.97264253
31respiratory chain complex IV assembly (GO:0008535)2.95950992
32fucose catabolic process (GO:0019317)2.95252522
33L-fucose metabolic process (GO:0042354)2.95252522
34L-fucose catabolic process (GO:0042355)2.95252522
35neuron fate determination (GO:0048664)2.95204612
36amino acid salvage (GO:0043102)2.94972082
37L-methionine salvage (GO:0071267)2.94972082
38L-methionine biosynthetic process (GO:0071265)2.94972082
39regulation of male gonad development (GO:2000018)2.93598607
40spermatid nucleus differentiation (GO:0007289)2.89765167
41polyol catabolic process (GO:0046174)2.88866604
42mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.86603037
43positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.86603037
44resolution of meiotic recombination intermediates (GO:0000712)2.83235156
45centriole replication (GO:0007099)2.80064432
46regulation of feeding behavior (GO:0060259)2.79991885
47regulation of cilium movement (GO:0003352)2.79783749
48inner ear receptor stereocilium organization (GO:0060122)2.77465324
49replication fork processing (GO:0031297)2.77055818
50regulation of acrosome reaction (GO:0060046)2.73557827
51lactate metabolic process (GO:0006089)2.71656447
52intra-S DNA damage checkpoint (GO:0031573)2.71136302
53meiotic cell cycle (GO:0051321)2.70615600
54head development (GO:0060322)2.70268420
55recombinational repair (GO:0000725)2.67814197
56male meiosis I (GO:0007141)2.67782349
57photoreceptor cell maintenance (GO:0045494)2.67692958
58cerebral cortex radially oriented cell migration (GO:0021799)2.67448522
59negative regulation of mast cell activation (GO:0033004)2.66722487
60double-strand break repair via homologous recombination (GO:0000724)2.66286952
61methionine biosynthetic process (GO:0009086)2.64539517
62microtubule anchoring (GO:0034453)2.63779524
63methionine metabolic process (GO:0006555)2.62575069
64DNA integration (GO:0015074)2.62059424
65protein deneddylation (GO:0000338)2.61985833
66regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.61909395
67reciprocal DNA recombination (GO:0035825)2.58798509
68reciprocal meiotic recombination (GO:0007131)2.58798509
69mitochondrial respiratory chain complex I assembly (GO:0032981)2.58663736
70NADH dehydrogenase complex assembly (GO:0010257)2.58663736
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58663736
72acrosome assembly (GO:0001675)2.57127464
73kinetochore organization (GO:0051383)2.56963138
74epithelial cilium movement (GO:0003351)2.54699695
75neuron cell-cell adhesion (GO:0007158)2.51190273
76postsynaptic membrane organization (GO:0001941)2.49065557
77regulation of action potential (GO:0098900)2.48645125
78cilium organization (GO:0044782)2.48294267
79regulation of helicase activity (GO:0051095)2.48268069
80attachment of spindle microtubules to kinetochore (GO:0008608)2.47187384
81protein polyglutamylation (GO:0018095)2.46500954
82cilium assembly (GO:0042384)2.45991468
83outer ear morphogenesis (GO:0042473)2.45713760
84positive regulation of mitochondrial fission (GO:0090141)2.43427899
85vocalization behavior (GO:0071625)2.40290071
86auditory receptor cell stereocilium organization (GO:0060088)2.37193713
87regulation of development, heterochronic (GO:0040034)2.36475025
88chromosome organization involved in meiosis (GO:0070192)2.35764118
89limb bud formation (GO:0060174)2.35445272
90protein complex biogenesis (GO:0070271)2.33874004
91pyrimidine nucleobase catabolic process (GO:0006208)2.33151404
92photoreceptor cell development (GO:0042461)2.32590500
93regulation of DNA endoreduplication (GO:0032875)2.32229097
94peptidyl-lysine trimethylation (GO:0018023)2.31345142
95positive regulation of gastrulation (GO:2000543)2.30209440
96meiotic chromosome segregation (GO:0045132)2.29275530
97regulation of glucokinase activity (GO:0033131)2.29171778
98regulation of hexokinase activity (GO:1903299)2.29171778
99tachykinin receptor signaling pathway (GO:0007217)2.28720011
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.28180395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.83167595
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.28558261
3EZH2_22144423_ChIP-Seq_EOC_Human3.16420164
4GBX2_23144817_ChIP-Seq_PC3_Human3.04348987
5VDR_22108803_ChIP-Seq_LS180_Human2.96939317
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82415280
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77084734
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71751747
9FUS_26573619_Chip-Seq_HEK293_Human2.70763611
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.65767180
11EWS_26573619_Chip-Seq_HEK293_Human2.53228063
12IGF1R_20145208_ChIP-Seq_DFB_Human2.44231567
13P300_19829295_ChIP-Seq_ESCs_Human2.23104097
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21653024
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00886801
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94946713
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92451338
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92116254
19TAF15_26573619_Chip-Seq_HEK293_Human1.85301131
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82173596
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.81175870
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79344371
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78659880
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.77231527
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76117355
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.74052668
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72916078
28SMAD4_21799915_ChIP-Seq_A2780_Human1.71665015
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.71164204
30* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66213497
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.65303325
32* IRF1_19129219_ChIP-ChIP_H3396_Human1.63220050
33* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60469934
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59360601
35MYC_18940864_ChIP-ChIP_HL60_Human1.58971451
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56836150
37STAT3_23295773_ChIP-Seq_U87_Human1.56539060
38ELK1_19687146_ChIP-ChIP_HELA_Human1.54229438
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51394045
40BCAT_22108803_ChIP-Seq_LS180_Human1.50763153
41AR_25329375_ChIP-Seq_VCAP_Human1.49446033
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.49107859
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.45491216
44TCF4_23295773_ChIP-Seq_U87_Human1.42317511
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41383514
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.39297760
47TCF4_22108803_ChIP-Seq_LS180_Human1.39278540
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38593206
49RUNX2_22187159_ChIP-Seq_PCA_Human1.37208054
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35383410
51ER_23166858_ChIP-Seq_MCF-7_Human1.35123489
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34326830
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32108661
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31917387
55RNF2_27304074_Chip-Seq_NSC_Mouse1.30860042
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30674981
57CBP_20019798_ChIP-Seq_JUKART_Human1.30674981
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28912875
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27478376
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26119419
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25834936
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25834936
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22472801
64SOX2_19829295_ChIP-Seq_ESCs_Human1.21878551
65NANOG_19829295_ChIP-Seq_ESCs_Human1.21878551
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.20127770
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19865362
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17670553
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.16265401
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16222544
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14847545
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14467409
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13989623
74JUN_21703547_ChIP-Seq_K562_Human1.13831313
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.12321235
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.12094708
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12070172
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11776748
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11620249
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10374950
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09592748
82TP53_22573176_ChIP-Seq_HFKS_Human1.09147116
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08019714
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06723671
85VDR_23849224_ChIP-Seq_CD4+_Human1.06148797
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05487417
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04934493
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04254571
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.99721915
90P53_22387025_ChIP-Seq_ESCs_Mouse0.98120752
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97596755
92EZH2_27304074_Chip-Seq_ESCs_Mouse0.97266752
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.96415251
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.96173632
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94838850
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94488160
97REST_21632747_ChIP-Seq_MESCs_Mouse0.93033278
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.92270983
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.91217402
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91148644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.16963646
2MP0006292_abnormal_olfactory_placode3.01652585
3MP0008058_abnormal_DNA_repair2.97567282
4MP0003718_maternal_effect2.57006331
5MP0009780_abnormal_chondrocyte_physiolo2.34104515
6MP0008789_abnormal_olfactory_epithelium2.31455505
7MP0002102_abnormal_ear_morphology2.28594675
8MP0002234_abnormal_pharynx_morphology2.08145071
9MP0003890_abnormal_embryonic-extraembry2.03995318
10MP0006054_spinal_hemorrhage2.01065503
11MP0005551_abnormal_eye_electrophysiolog1.96506106
12MP0004043_abnormal_pH_regulation1.95856711
13MP0004142_abnormal_muscle_tone1.94519269
14MP0004133_heterotaxia1.84998678
15MP0001986_abnormal_taste_sensitivity1.81095224
16MP0001486_abnormal_startle_reflex1.79859694
17MP0003567_abnormal_fetal_cardiomyocyte1.76232576
18MP0000049_abnormal_middle_ear1.75822456
19MP0000647_abnormal_sebaceous_gland1.74324878
20MP0003787_abnormal_imprinting1.73790861
21MP0000631_abnormal_neuroendocrine_gland1.73353006
22MP0003121_genomic_imprinting1.72607134
23MP0005499_abnormal_olfactory_system1.70522017
24MP0005394_taste/olfaction_phenotype1.70522017
25MP0008995_early_reproductive_senescence1.61754537
26MP0003136_yellow_coat_color1.61655147
27MP0002837_dystrophic_cardiac_calcinosis1.59833739
28MP0000427_abnormal_hair_cycle1.52068198
29MP0008057_abnormal_DNA_replication1.51758222
30MP0000383_abnormal_hair_follicle1.50305438
31MP0003119_abnormal_digestive_system1.49957945
32MP0004885_abnormal_endolymph1.47401505
33MP0001501_abnormal_sleep_pattern1.45762090
34MP0009745_abnormal_behavioral_response1.41250074
35MP0002233_abnormal_nose_morphology1.40857929
36MP0006072_abnormal_retinal_apoptosis1.39819232
37MP0010094_abnormal_chromosome_stability1.37074925
38MP0004145_abnormal_muscle_electrophysio1.36276476
39MP0003755_abnormal_palate_morphology1.36027201
40MP0002736_abnormal_nociception_after1.34009508
41MP0005187_abnormal_penis_morphology1.32207149
42MP0005379_endocrine/exocrine_gland_phen1.31666310
43MP0002272_abnormal_nervous_system1.30935864
44MP0008961_abnormal_basal_metabolism1.29957124
45MP0006276_abnormal_autonomic_nervous1.29332370
46MP0003937_abnormal_limbs/digits/tail_de1.28593274
47MP0002735_abnormal_chemical_nociception1.28295964
48MP0003880_abnormal_central_pattern1.25026339
49MP0005253_abnormal_eye_physiology1.23359051
50MP0003283_abnormal_digestive_organ1.22492464
51MP0002210_abnormal_sex_determination1.21658491
52MP0001929_abnormal_gametogenesis1.18613336
53MP0001188_hyperpigmentation1.17429112
54MP0002876_abnormal_thyroid_physiology1.16442901
55MP0001968_abnormal_touch/_nociception1.16012456
56MP0000653_abnormal_sex_gland1.15906403
57MP0000778_abnormal_nervous_system1.15595572
58MP0001529_abnormal_vocalization1.13428656
59MP0004134_abnormal_chest_morphology1.11623333
60MP0001293_anophthalmia1.10651993
61MP0004215_abnormal_myocardial_fiber1.09496009
62MP0002734_abnormal_mechanical_nocicepti1.09126351
63MP0009046_muscle_twitch1.08483721
64MP0001984_abnormal_olfaction1.08271048
65MP0002928_abnormal_bile_duct1.08181283
66MP0003635_abnormal_synaptic_transmissio1.05678473
67MP0002638_abnormal_pupillary_reflex1.04788006
68MP0010678_abnormal_skin_adnexa1.03807663
69MP0003698_abnormal_male_reproductive1.03245710
70MP0002751_abnormal_autonomic_nervous1.03141710
71MP0002163_abnormal_gland_morphology1.03013138
72MP0002572_abnormal_emotion/affect_behav1.01387846
73MP0004147_increased_porphyrin_level1.00709173
74MP0005386_behavior/neurological_phenoty1.00659510
75MP0004924_abnormal_behavior1.00659510
76MP0002653_abnormal_ependyma_morphology0.99061028
77MP0005084_abnormal_gallbladder_morpholo0.98105512
78MP0009250_abnormal_appendicular_skeleto0.97688105
79MP0002938_white_spotting0.97624060
80MP0004270_analgesia0.95176666
81MP0003385_abnormal_body_wall0.93561627
82MP0002557_abnormal_social/conspecific_i0.93204845
83MP0000462_abnormal_digestive_system0.93190103
84MP0001145_abnormal_male_reproductive0.93097841
85MP0005248_abnormal_Harderian_gland0.92071922
86MP0002095_abnormal_skin_pigmentation0.91657381
87MP0001286_abnormal_eye_development0.91299432
88MP0003938_abnormal_ear_development0.90237499
89MP0001299_abnormal_eye_distance/0.89444522
90MP0000566_synostosis0.89171374
91MP0000013_abnormal_adipose_tissue0.85712624
92MP0005195_abnormal_posterior_eye0.85440259
93MP0005646_abnormal_pituitary_gland0.84997555
94MP0003786_premature_aging0.83555610
95MP0002752_abnormal_somatic_nervous0.83335903
96MP0000026_abnormal_inner_ear0.81764143
97MP0003646_muscle_fatigue0.81749504
98MP0002177_abnormal_outer_ear0.80635881
99MP0000613_abnormal_salivary_gland0.80581096
100MP0001119_abnormal_female_reproductive0.79974438

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.95399546
2Pancreatic fibrosis (HP:0100732)3.76391401
3Colon cancer (HP:0003003)3.53862068
4Pancreatic cysts (HP:0001737)3.48916538
5Molar tooth sign on MRI (HP:0002419)3.41825450
6Abnormality of midbrain morphology (HP:0002418)3.41825450
7Medial flaring of the eyebrow (HP:0010747)3.40263936
8True hermaphroditism (HP:0010459)3.33647314
9Nephronophthisis (HP:0000090)3.27701436
10Gait imbalance (HP:0002141)3.07514103
11Supernumerary spleens (HP:0009799)3.05439689
12Congenital primary aphakia (HP:0007707)3.03447441
13Nephrogenic diabetes insipidus (HP:0009806)2.97994393
14Abnormality of the labia minora (HP:0012880)2.89928749
15Volvulus (HP:0002580)2.87607683
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79576530
17Chronic hepatic failure (HP:0100626)2.76618229
18Calf muscle hypertrophy (HP:0008981)2.76383707
19Abnormality of the renal medulla (HP:0100957)2.75118695
20Abnormal biliary tract physiology (HP:0012439)2.67614379
21Bile duct proliferation (HP:0001408)2.67614379
22Progressive macrocephaly (HP:0004481)2.57809404
23Protruding tongue (HP:0010808)2.57197266
24Abnormal rod and cone electroretinograms (HP:0008323)2.57029370
25Acute necrotizing encephalopathy (HP:0006965)2.55754134
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.51831177
27Muscle hypertrophy of the lower extremities (HP:0008968)2.47829377
28Genital tract atresia (HP:0001827)2.47359502
29Attenuation of retinal blood vessels (HP:0007843)2.43754599
30Intestinal atresia (HP:0011100)2.42829199
31Broad-based gait (HP:0002136)2.37400282
32Aplasia/hypoplasia of the uterus (HP:0008684)2.37170522
33Vaginal atresia (HP:0000148)2.36395182
34Acute encephalopathy (HP:0006846)2.34924306
35Papillary thyroid carcinoma (HP:0002895)2.33626713
36Methylmalonic acidemia (HP:0002912)2.33163537
37Median cleft lip (HP:0000161)2.29884921
38Hepatocellular necrosis (HP:0001404)2.24521507
39Shoulder girdle muscle weakness (HP:0003547)2.17223986
40Congenital stationary night blindness (HP:0007642)2.17099660
41Sclerocornea (HP:0000647)2.14303878
42Atonic seizures (HP:0010819)2.13175270
43Medulloblastoma (HP:0002885)2.12778920
44Stomach cancer (HP:0012126)2.12286537
45Cystic liver disease (HP:0006706)2.10814189
46Increased CSF lactate (HP:0002490)2.10382479
47Absent speech (HP:0001344)2.10194695
48Hyperglycinemia (HP:0002154)2.08067654
49Narrow forehead (HP:0000341)2.07174152
50Neoplasm of the oral cavity (HP:0100649)2.07012091
51Mitochondrial inheritance (HP:0001427)2.05905599
52Drooling (HP:0002307)2.02711509
53Abnormality of the renal cortex (HP:0011035)1.99595773
54Hypoplastic labia majora (HP:0000059)1.99349680
55Abnormal mitochondria in muscle tissue (HP:0008316)1.98871599
56CNS hypomyelination (HP:0003429)1.97815943
57Bony spicule pigmentary retinopathy (HP:0007737)1.95105463
58Asplenia (HP:0001746)1.94386649
59Congenital hepatic fibrosis (HP:0002612)1.94329043
60Gaze-evoked nystagmus (HP:0000640)1.93123988
61Aplasia/Hypoplasia of the spleen (HP:0010451)1.92621604
62Hepatic necrosis (HP:0002605)1.91792464
63Abnormality of the musculature of the pelvis (HP:0001469)1.91278005
64Abnormality of the hip-girdle musculature (HP:0001445)1.91278005
65Poor coordination (HP:0002370)1.90377472
66Split foot (HP:0001839)1.89437716
67Septo-optic dysplasia (HP:0100842)1.88689746
68Male pseudohermaphroditism (HP:0000037)1.86939174
69Unsteady gait (HP:0002317)1.84244656
70Anencephaly (HP:0002323)1.84160975
71Sloping forehead (HP:0000340)1.83630783
72Pendular nystagmus (HP:0012043)1.82354026
73Hyperglycinuria (HP:0003108)1.82288992
74Furrowed tongue (HP:0000221)1.80232702
75Rhabdomyosarcoma (HP:0002859)1.80223239
76Abnormality of the labia majora (HP:0012881)1.80059057
77Decreased testicular size (HP:0008734)1.79753817
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.79400061
79Excessive salivation (HP:0003781)1.78240382
80Postaxial foot polydactyly (HP:0001830)1.76599904
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74360085
82Degeneration of the lateral corticospinal tracts (HP:0002314)1.74360085
83Abnormality of the metopic suture (HP:0005556)1.74323039
84Adrenal hypoplasia (HP:0000835)1.74291710
85Tubular atrophy (HP:0000092)1.73172663
86Abnormality of vitamin B metabolism (HP:0004340)1.72774388
87Aplasia/Hypoplasia of the lens (HP:0008063)1.72545478
88Astigmatism (HP:0000483)1.71908762
89Postaxial hand polydactyly (HP:0001162)1.71455812
90Thyroid carcinoma (HP:0002890)1.71056142
91Hemiparesis (HP:0001269)1.69557396
92Glioma (HP:0009733)1.67221872
93Abnormality of glycine metabolism (HP:0010895)1.66125369
94Abnormality of serine family amino acid metabolism (HP:0010894)1.66125369
95Cerebral edema (HP:0002181)1.65574664
96Broad foot (HP:0001769)1.65430564
97Abnormal lung lobation (HP:0002101)1.63919221
98Widely spaced teeth (HP:0000687)1.63918100
99Optic disc pallor (HP:0000543)1.62990650
100Absent septum pellucidum (HP:0001331)1.62820962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.29931918
2FRK3.15893196
3TNIK2.97067793
4MAP3K42.62155928
5ACVR1B2.35761575
6PINK12.22513949
7BRSK22.15450023
8STK38L2.11671227
9WNK32.06805592
10GRK11.92488056
11EIF2AK31.91552089
12BMPR1B1.86638856
13PNCK1.86398232
14NUAK11.73759070
15MAPK131.72369942
16CCNB11.69825272
17NEK11.60339927
18MAP2K71.55851649
19MKNK21.53490695
20BRD41.47776058
21CSNK1G11.43689703
22MAP4K21.40193977
23ADRBK21.39473376
24PHKG21.37041957
25PHKG11.37041957
26CSNK1G21.28366348
27ZAK1.26488659
28MARK11.18779646
29SRPK11.10024259
30CSNK1G31.09090819
31PLK31.08289672
32PRKCE1.08028811
33AKT31.05514341
34MAP3K91.02221414
35NLK1.01906022
36STK161.01628668
37MAP2K41.00147773
38ERBB30.98576079
39CSNK1A1L0.97383969
40MKNK10.97180923
41PAK30.95129672
42PLK20.93292948
43INSRR0.92733846
44TRIM280.92240723
45TGFBR10.92042563
46EIF2AK10.89170636
47OBSCN0.88688251
48MAP3K60.87883144
49WEE10.87369428
50TTK0.86836061
51PRKCG0.86525113
52FLT30.85352701
53NTRK20.85097781
54VRK10.84652554
55MET0.83842223
56CDC70.83322128
57SGK20.83297132
58RPS6KA40.81386876
59EPHA40.80331104
60ARAF0.78928399
61BRAF0.78079082
62TAF10.77467182
63FGFR20.74915310
64PLK10.74009646
65DYRK20.73693907
66BUB10.70609903
67BCR0.70076873
68BRSK10.69606390
69WNK40.65994180
70STK390.65690919
71STK30.65045995
72ATM0.62437660
73PRKCI0.59458732
74PASK0.59130146
75PRKG10.55264529
76PLK40.55246130
77FGFR10.54898024
78MST40.53241222
79DYRK30.52733111
80NTRK30.52420983
81CSNK1E0.51810170
82NEK60.48536468
83MUSK0.46998867
84PRKACB0.46832688
85SGK4940.46266900
86SGK2230.46266900
87TSSK60.44914260
88PKN10.44219525
89PIK3CA0.44040103
90ADRBK10.42545798
91CAMKK20.42465578
92PRKD30.42175741
93PRKACA0.40801901
94CDK190.39418403
95CSNK1D0.39376126
96NEK20.38617967
97EIF2AK20.37501183
98KSR10.36022534
99MATK0.35257811
100OXSR10.35120306

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030222.88975691
2Non-homologous end-joining_Homo sapiens_hsa034502.77852496
3Nicotine addiction_Homo sapiens_hsa050332.54150049
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47437071
5Phototransduction_Homo sapiens_hsa047442.45259188
6Homologous recombination_Homo sapiens_hsa034402.38467759
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37448873
8Fanconi anemia pathway_Homo sapiens_hsa034602.23802637
9Propanoate metabolism_Homo sapiens_hsa006402.23169369
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22644191
11Caffeine metabolism_Homo sapiens_hsa002322.12569459
12Protein export_Homo sapiens_hsa030601.96262226
13RNA degradation_Homo sapiens_hsa030181.94781379
14Oxidative phosphorylation_Homo sapiens_hsa001901.91568171
15Mismatch repair_Homo sapiens_hsa034301.90865959
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90532239
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76720827
18Nucleotide excision repair_Homo sapiens_hsa034201.65843414
19RNA polymerase_Homo sapiens_hsa030201.63870815
20RNA transport_Homo sapiens_hsa030131.62946082
21Butanoate metabolism_Homo sapiens_hsa006501.54922641
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54770039
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.54164653
24Parkinsons disease_Homo sapiens_hsa050121.53364603
25Selenocompound metabolism_Homo sapiens_hsa004501.53273847
26Linoleic acid metabolism_Homo sapiens_hsa005911.47135085
27Circadian rhythm_Homo sapiens_hsa047101.41827589
28Taste transduction_Homo sapiens_hsa047421.41559875
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33870390
30Ether lipid metabolism_Homo sapiens_hsa005651.33705789
31One carbon pool by folate_Homo sapiens_hsa006701.31538034
32Huntingtons disease_Homo sapiens_hsa050161.25006147
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.21386983
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20293956
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.17238673
36Hedgehog signaling pathway_Homo sapiens_hsa043401.15522535
37Vitamin B6 metabolism_Homo sapiens_hsa007501.13875454
38Base excision repair_Homo sapiens_hsa034101.13550093
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12453042
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09682012
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08816006
42Proteasome_Homo sapiens_hsa030501.06939606
43Cardiac muscle contraction_Homo sapiens_hsa042601.06881064
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04140602
45Basal cell carcinoma_Homo sapiens_hsa052170.98034551
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95096575
47Peroxisome_Homo sapiens_hsa041460.93156931
48Tryptophan metabolism_Homo sapiens_hsa003800.92533215
49GABAergic synapse_Homo sapiens_hsa047270.90938527
50Purine metabolism_Homo sapiens_hsa002300.90761192
51Collecting duct acid secretion_Homo sapiens_hsa049660.89647540
52beta-Alanine metabolism_Homo sapiens_hsa004100.88299061
53Alzheimers disease_Homo sapiens_hsa050100.85955225
54Insulin secretion_Homo sapiens_hsa049110.85343756
55Cell cycle_Homo sapiens_hsa041100.85233317
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82815690
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82722779
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82414416
59Olfactory transduction_Homo sapiens_hsa047400.81526385
60Chemical carcinogenesis_Homo sapiens_hsa052040.80714972
61Dorso-ventral axis formation_Homo sapiens_hsa043200.80642386
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.80423715
63Steroid biosynthesis_Homo sapiens_hsa001000.79202945
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78933885
65mRNA surveillance pathway_Homo sapiens_hsa030150.77451906
66Oocyte meiosis_Homo sapiens_hsa041140.77066477
67Regulation of autophagy_Homo sapiens_hsa041400.76413316
68Ovarian steroidogenesis_Homo sapiens_hsa049130.75106630
69Retinol metabolism_Homo sapiens_hsa008300.73842695
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73673776
71Long-term depression_Homo sapiens_hsa047300.72974047
72Morphine addiction_Homo sapiens_hsa050320.70600499
73Glutamatergic synapse_Homo sapiens_hsa047240.70161501
74Serotonergic synapse_Homo sapiens_hsa047260.69686711
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68129813
76Spliceosome_Homo sapiens_hsa030400.66906012
77Folate biosynthesis_Homo sapiens_hsa007900.63814142
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63431983
79Metabolic pathways_Homo sapiens_hsa011000.63182717
80Dopaminergic synapse_Homo sapiens_hsa047280.62494427
81Circadian entrainment_Homo sapiens_hsa047130.61087542
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58268321
83p53 signaling pathway_Homo sapiens_hsa041150.57931200
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57636012
85DNA replication_Homo sapiens_hsa030300.56347905
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55929525
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55906667
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52061267
89Nitrogen metabolism_Homo sapiens_hsa009100.51677370
90Pyrimidine metabolism_Homo sapiens_hsa002400.51429247
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51170035
92Pyruvate metabolism_Homo sapiens_hsa006200.50348712
93Amphetamine addiction_Homo sapiens_hsa050310.48168720
94Sulfur metabolism_Homo sapiens_hsa009200.47128217
95Wnt signaling pathway_Homo sapiens_hsa043100.46116589
96Synaptic vesicle cycle_Homo sapiens_hsa047210.44574440
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44341988
98TGF-beta signaling pathway_Homo sapiens_hsa043500.42505590
99Glutathione metabolism_Homo sapiens_hsa004800.41732905
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38685378

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