ZNF500

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.56154168
2DNA deamination (GO:0045006)4.49324769
3response to pheromone (GO:0019236)4.01136919
4fucose catabolic process (GO:0019317)3.88199584
5L-fucose metabolic process (GO:0042354)3.88199584
6L-fucose catabolic process (GO:0042355)3.88199584
7water-soluble vitamin biosynthetic process (GO:0042364)3.82492200
8negative regulation of telomere maintenance (GO:0032205)3.79579999
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77522331
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.77522331
11NADH dehydrogenase complex assembly (GO:0010257)3.77522331
12indolalkylamine metabolic process (GO:0006586)3.71420575
13protein complex biogenesis (GO:0070271)3.70621986
14detection of light stimulus involved in sensory perception (GO:0050962)3.55667067
15detection of light stimulus involved in visual perception (GO:0050908)3.55667067
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45580254
17protein polyglutamylation (GO:0018095)3.45095102
18respiratory chain complex IV assembly (GO:0008535)3.44823406
19cornea development in camera-type eye (GO:0061303)3.44741018
20piRNA metabolic process (GO:0034587)3.41842474
21mitochondrial respiratory chain complex assembly (GO:0033108)3.41528066
22tryptophan catabolic process (GO:0006569)3.38062850
23indole-containing compound catabolic process (GO:0042436)3.38062850
24indolalkylamine catabolic process (GO:0046218)3.38062850
25cytochrome complex assembly (GO:0017004)3.35421141
26axoneme assembly (GO:0035082)3.32977034
27kynurenine metabolic process (GO:0070189)3.27761092
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.21171834
29preassembly of GPI anchor in ER membrane (GO:0016254)3.21136929
30cellular response to ATP (GO:0071318)3.20435160
31DNA methylation involved in gamete generation (GO:0043046)3.17667173
32negative regulation of transcription regulatory region DNA binding (GO:2000678)3.15663296
33somite development (GO:0061053)3.10110876
34cellular ketone body metabolic process (GO:0046950)3.03240245
35tryptophan metabolic process (GO:0006568)2.99793027
36neural tube formation (GO:0001841)2.96979927
37epithelial cilium movement (GO:0003351)2.96689161
38regulation of cilium movement (GO:0003352)2.94250335
39negative regulation of mast cell activation (GO:0033004)2.94247084
40mannosylation (GO:0097502)2.91453131
41regulation of telomere maintenance (GO:0032204)2.91186546
42nonmotile primary cilium assembly (GO:0035058)2.88196444
43positive regulation of triglyceride biosynthetic process (GO:0010867)2.85724766
44replication fork processing (GO:0031297)2.85533657
45behavioral response to ethanol (GO:0048149)2.83042377
46kidney morphogenesis (GO:0060993)2.81786272
47detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79239819
48ketone body metabolic process (GO:1902224)2.78287527
49indole-containing compound metabolic process (GO:0042430)2.76816793
50amine catabolic process (GO:0009310)2.76374799
51cellular biogenic amine catabolic process (GO:0042402)2.76374799
52sulfation (GO:0051923)2.76213376
53rRNA catabolic process (GO:0016075)2.75576956
54transmission of nerve impulse (GO:0019226)2.73060663
55regulation of hexokinase activity (GO:1903299)2.72777740
56regulation of glucokinase activity (GO:0033131)2.72777740
57recombinational repair (GO:0000725)2.71942086
58double-strand break repair via homologous recombination (GO:0000724)2.71909921
59neuronal action potential (GO:0019228)2.71281804
60nephron epithelium morphogenesis (GO:0072088)2.69392861
61nephron tubule morphogenesis (GO:0072078)2.69392861
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69166582
63ubiquinone biosynthetic process (GO:0006744)2.68020775
64cell proliferation in forebrain (GO:0021846)2.67958739
65regulation of translation, ncRNA-mediated (GO:0045974)2.67869430
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67869430
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.67869430
68pyrimidine nucleobase catabolic process (GO:0006208)2.67544056
69gamma-aminobutyric acid transport (GO:0015812)2.67372310
70spinal cord motor neuron differentiation (GO:0021522)2.66705883
71regulation of hippo signaling (GO:0035330)2.66262794
72positive regulation of fatty acid transport (GO:2000193)2.65437024
73positive regulation of defense response to virus by host (GO:0002230)2.65178452
74protein K6-linked ubiquitination (GO:0085020)2.61269851
75negative regulation of systemic arterial blood pressure (GO:0003085)2.59029988
76cilium movement (GO:0003341)2.58680797
77embryonic epithelial tube formation (GO:0001838)2.56014336
78regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55965276
79GPI anchor metabolic process (GO:0006505)2.54727660
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52019603
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51823711
82synaptic transmission, cholinergic (GO:0007271)2.49870148
83oxidative demethylation (GO:0070989)2.49174838
84rhodopsin mediated signaling pathway (GO:0016056)2.49035966
85transepithelial transport (GO:0070633)2.48659073
86regulation of mesoderm development (GO:2000380)2.48534101
87primary amino compound metabolic process (GO:1901160)2.48284410
88regulation of neurotransmitter uptake (GO:0051580)2.48008072
89ubiquinone metabolic process (GO:0006743)2.47722493
90protein-cofactor linkage (GO:0018065)2.47670977
91negative regulation of reactive oxygen species metabolic process (GO:2000378)2.46331219
92positive regulation of mitochondrial fission (GO:0090141)2.45364677
93adaptation of signaling pathway (GO:0023058)2.45157098
94regulation of triglyceride biosynthetic process (GO:0010866)2.44339611
95cilium organization (GO:0044782)2.43920541
96cilium morphogenesis (GO:0060271)2.43234889
97cellular response to exogenous dsRNA (GO:0071360)2.40406252
98tRNA modification (GO:0006400)2.40291336
99glycerophospholipid catabolic process (GO:0046475)2.38654531
100serotonin metabolic process (GO:0042428)2.38525953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.49618157
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65540661
3VDR_22108803_ChIP-Seq_LS180_Human3.35644878
4EZH2_22144423_ChIP-Seq_EOC_Human2.95344814
5GBX2_23144817_ChIP-Seq_PC3_Human2.71467202
6* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53725350
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.35394005
8IGF1R_20145208_ChIP-Seq_DFB_Human2.29590214
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24385180
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11792459
11EWS_26573619_Chip-Seq_HEK293_Human2.10003421
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07791226
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99694772
14IRF1_19129219_ChIP-ChIP_H3396_Human1.96862192
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92601697
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88791843
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.81814330
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.80806249
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76228804
20FUS_26573619_Chip-Seq_HEK293_Human1.71634803
21MYC_18940864_ChIP-ChIP_HL60_Human1.65058260
22ER_23166858_ChIP-Seq_MCF-7_Human1.63936303
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63541487
24REST_21632747_ChIP-Seq_MESCs_Mouse1.62346181
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61465913
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57637104
27TP53_22573176_ChIP-Seq_HFKS_Human1.55154553
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55074274
29P300_19829295_ChIP-Seq_ESCs_Human1.49990729
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49637853
31TAF15_26573619_Chip-Seq_HEK293_Human1.46296334
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.41284406
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.40565869
34GATA3_21878914_ChIP-Seq_MCF-7_Human1.40407133
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33640871
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33433314
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33433314
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32115356
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31897617
40RNF2_27304074_Chip-Seq_NSC_Mouse1.31346430
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30964883
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.30630783
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.30467802
44ERA_21632823_ChIP-Seq_H3396_Human1.30432199
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29378553
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28624311
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27611573
48AR_25329375_ChIP-Seq_VCAP_Human1.27318932
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27152676
50STAT3_23295773_ChIP-Seq_U87_Human1.26830762
51TCF4_23295773_ChIP-Seq_U87_Human1.25123921
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.25062806
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25062806
54NCOR_22424771_ChIP-Seq_293T_Human1.24204194
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24000822
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21263933
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20931620
58BCAT_22108803_ChIP-Seq_LS180_Human1.20802374
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19247902
60HOXB7_26014856_ChIP-Seq_BT474_Human1.17807740
61CBP_20019798_ChIP-Seq_JUKART_Human1.17358230
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17358230
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.17290237
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15425899
65VDR_23849224_ChIP-Seq_CD4+_Human1.14731336
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.14161057
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12461007
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11568336
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11451059
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.10672335
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.10367634
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10159255
73* ETS1_20019798_ChIP-Seq_JURKAT_Human1.09692984
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08975646
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08594073
76NANOG_19829295_ChIP-Seq_ESCs_Human1.08340863
77SOX2_19829295_ChIP-Seq_ESCs_Human1.08340863
78DROSHA_22980978_ChIP-Seq_HELA_Human1.07842897
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.07045905
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.05915144
81TAF2_19829295_ChIP-Seq_ESCs_Human1.05914727
82AR_20517297_ChIP-Seq_VCAP_Human1.05432004
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05372111
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04442762
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03893097
86SMAD4_21799915_ChIP-Seq_A2780_Human1.03659994
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03487867
88TCF4_22108803_ChIP-Seq_LS180_Human1.03122937
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01257693
90OCT4_20526341_ChIP-Seq_ESCs_Human0.99961066
91NANOG_20526341_ChIP-Seq_ESCs_Human0.97561217
92MYC_19829295_ChIP-Seq_ESCs_Human0.97424622
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.95806426
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95341319
95P53_21459846_ChIP-Seq_SAOS-2_Human0.95242861
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94883483
97RUNX2_22187159_ChIP-Seq_PCA_Human0.94800782
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94004578
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93869054
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93839757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.12781494
2MP0006292_abnormal_olfactory_placode2.80203201
3MP0001968_abnormal_touch/_nociception2.55473143
4MP0005646_abnormal_pituitary_gland2.41980394
5MP0003787_abnormal_imprinting2.40856848
6MP0003646_muscle_fatigue2.39459514
7MP0005551_abnormal_eye_electrophysiolog2.34073896
8MP0002653_abnormal_ependyma_morphology2.33894094
9MP0002736_abnormal_nociception_after2.17399908
10MP0003136_yellow_coat_color2.16108365
11MP0002876_abnormal_thyroid_physiology2.10704855
12MP0002102_abnormal_ear_morphology2.10368714
13MP0008872_abnormal_physiological_respon2.08322240
14MP0003195_calcinosis2.05732746
15MP0002837_dystrophic_cardiac_calcinosis1.96193187
16MP0004133_heterotaxia1.91907968
17MP0004885_abnormal_endolymph1.89361350
18MP0006072_abnormal_retinal_apoptosis1.85170998
19MP0005645_abnormal_hypothalamus_physiol1.80125781
20MP0000372_irregular_coat_pigmentation1.72637726
21MP0004142_abnormal_muscle_tone1.71838728
22MP0000631_abnormal_neuroendocrine_gland1.70813903
23MP0008875_abnormal_xenobiotic_pharmacok1.69521795
24MP0001986_abnormal_taste_sensitivity1.69453573
25MP0009745_abnormal_behavioral_response1.66775380
26MP0002160_abnormal_reproductive_system1.64138289
27MP0009046_muscle_twitch1.61410888
28MP0001485_abnormal_pinna_reflex1.58411264
29MP0002272_abnormal_nervous_system1.57707219
30MP0002638_abnormal_pupillary_reflex1.57405253
31MP0005174_abnormal_tail_pigmentation1.56610217
32MP0003880_abnormal_central_pattern1.56270597
33MP0006276_abnormal_autonomic_nervous1.48573929
34MP0005253_abnormal_eye_physiology1.46997014
35MP0008995_early_reproductive_senescence1.41852953
36MP0004043_abnormal_pH_regulation1.41734148
37MP0005389_reproductive_system_phenotype1.39482820
38MP0000015_abnormal_ear_pigmentation1.34977391
39MP0000427_abnormal_hair_cycle1.29827225
40MP0002163_abnormal_gland_morphology1.29340957
41MP0000569_abnormal_digit_pigmentation1.29238479
42MP0002938_white_spotting1.28779259
43MP0001486_abnormal_startle_reflex1.24917100
44MP0002064_seizures1.21210388
45MP0005075_abnormal_melanosome_morpholog1.21153562
46MP0005084_abnormal_gallbladder_morpholo1.20287583
47MP0002572_abnormal_emotion/affect_behav1.20035504
48MP0002735_abnormal_chemical_nociception1.18715995
49MP0003011_delayed_dark_adaptation1.15805562
50MP0005379_endocrine/exocrine_gland_phen1.13370418
51MP0004147_increased_porphyrin_level1.11816457
52MP0003283_abnormal_digestive_organ1.10681897
53MP0001970_abnormal_pain_threshold1.09987156
54MP0005195_abnormal_posterior_eye1.09578382
55MP0010386_abnormal_urinary_bladder1.08801360
56MP0002733_abnormal_thermal_nociception1.08771414
57MP0004145_abnormal_muscle_electrophysio1.08357244
58MP0002557_abnormal_social/conspecific_i1.07842152
59MP0002138_abnormal_hepatobiliary_system1.06979611
60MP0002751_abnormal_autonomic_nervous1.06389158
61MP0001501_abnormal_sleep_pattern1.06291879
62MP0000383_abnormal_hair_follicle1.06178782
63MP0002928_abnormal_bile_duct1.05802593
64MP0001529_abnormal_vocalization1.04493423
65MP0001984_abnormal_olfaction1.02671831
66MP0001919_abnormal_reproductive_system1.01958902
67MP0001764_abnormal_homeostasis1.00374066
68MP0000049_abnormal_middle_ear0.99110758
69MP0003635_abnormal_synaptic_transmissio0.98884894
70MP0003121_genomic_imprinting0.98309273
71MP0001502_abnormal_circadian_rhythm0.92864896
72MP0002184_abnormal_innervation0.92853931
73MP0004742_abnormal_vestibular_system0.92825461
74MP0002063_abnormal_learning/memory/cond0.91920651
75MP0002277_abnormal_respiratory_mucosa0.91621035
76MP0000026_abnormal_inner_ear0.91019782
77MP0002752_abnormal_somatic_nervous0.90160288
78MP0000778_abnormal_nervous_system0.88844940
79MP0008058_abnormal_DNA_repair0.88610234
80MP0008789_abnormal_olfactory_epithelium0.88099517
81MP0002067_abnormal_sensory_capabilities0.87731605
82MP0004924_abnormal_behavior0.87204684
83MP0005386_behavior/neurological_phenoty0.87204684
84MP0003698_abnormal_male_reproductive0.87127486
85MP0001324_abnormal_eye_pigmentation0.86905348
86MP0000538_abnormal_urinary_bladder0.86659168
87MP0001905_abnormal_dopamine_level0.86194024
88MP0000013_abnormal_adipose_tissue0.85738241
89MP0002095_abnormal_skin_pigmentation0.84394839
90MP0003938_abnormal_ear_development0.84327308
91MP0001963_abnormal_hearing_physiology0.82942321
92MP0003119_abnormal_digestive_system0.82046672
93MP0002229_neurodegeneration0.80620343
94MP0005332_abnormal_amino_acid0.79783849
95MP0002693_abnormal_pancreas_physiology0.79155277
96MP0001661_extended_life_span0.78707040
97MP0003718_maternal_effect0.78013030
98MP0002210_abnormal_sex_determination0.77831805
99MP0006035_abnormal_mitochondrial_morpho0.77280440
100MP0000516_abnormal_urinary_system0.76538861

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.38490171
2Congenital stationary night blindness (HP:0007642)3.95715331
3Molar tooth sign on MRI (HP:0002419)3.83882884
4Abnormality of midbrain morphology (HP:0002418)3.83882884
5Pancreatic fibrosis (HP:0100732)3.82570346
6Nephronophthisis (HP:0000090)3.76676803
7True hermaphroditism (HP:0010459)3.36491002
8Abnormality of the renal medulla (HP:0100957)3.24574638
9Type II lissencephaly (HP:0007260)3.21014288
10Tubular atrophy (HP:0000092)3.02446777
11Medial flaring of the eyebrow (HP:0010747)2.89434255
12Abnormality of the renal cortex (HP:0011035)2.86207642
13Abnormal rod and cone electroretinograms (HP:0008323)2.85214589
14Attenuation of retinal blood vessels (HP:0007843)2.84053000
15Hyperventilation (HP:0002883)2.79972471
16Abnormal drinking behavior (HP:0030082)2.75689719
17Polydipsia (HP:0001959)2.75689719
18Hyperalaninemia (HP:0003348)2.70119773
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70119773
20Abnormality of alanine metabolism (HP:0010916)2.70119773
21Pendular nystagmus (HP:0012043)2.66813497
22Cystic liver disease (HP:0006706)2.59596347
23Aplasia/Hypoplasia of the patella (HP:0006498)2.48572502
24Large for gestational age (HP:0001520)2.48050534
25Patellar aplasia (HP:0006443)2.47217897
26Abnormality of the renal collecting system (HP:0004742)2.44201883
27Hypoplasia of the pons (HP:0012110)2.34221136
28Sclerocornea (HP:0000647)2.34057421
29Abnormality of the pons (HP:0007361)2.30356645
30Protruding tongue (HP:0010808)2.29561045
31Abolished electroretinogram (ERG) (HP:0000550)2.27961083
32Methylmalonic acidemia (HP:0002912)2.27906125
33Cerebellar dysplasia (HP:0007033)2.26906758
34Chronic hepatic failure (HP:0100626)2.23996501
35Lissencephaly (HP:0001339)2.23755649
36Polyuria (HP:0000103)2.22375168
37Absent thumb (HP:0009777)2.22004347
38Gait imbalance (HP:0002141)2.20528716
39Severe muscular hypotonia (HP:0006829)2.20351796
40Inability to walk (HP:0002540)2.19867250
41Keratoconus (HP:0000563)2.17497560
42Increased corneal curvature (HP:0100692)2.17497560
43Methylmalonic aciduria (HP:0012120)2.15883514
44Duplicated collecting system (HP:0000081)2.15560495
45Acute necrotizing encephalopathy (HP:0006965)2.13262523
46Mitochondrial inheritance (HP:0001427)2.12598755
47Increased CSF lactate (HP:0002490)2.11588450
48Bony spicule pigmentary retinopathy (HP:0007737)2.10560750
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10085122
50Congenital hepatic fibrosis (HP:0002612)2.08146579
51Congenital primary aphakia (HP:0007707)2.08069646
52Absent/shortened dynein arms (HP:0200106)2.06354937
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.06354937
54Hepatocellular necrosis (HP:0001404)2.05640142
55Anencephaly (HP:0002323)2.05572492
56Gaze-evoked nystagmus (HP:0000640)2.05376253
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.04708167
58Broad-based gait (HP:0002136)2.01699763
59Abnormal biliary tract physiology (HP:0012439)2.00331443
60Bile duct proliferation (HP:0001408)2.00331443
61Nephrogenic diabetes insipidus (HP:0009806)2.00165076
62Tachypnea (HP:0002789)1.99381673
63Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99213205
64Asplenia (HP:0001746)1.95061884
65Chorioretinal atrophy (HP:0000533)1.95025291
66Pachygyria (HP:0001302)1.94696925
67Ketosis (HP:0001946)1.93976955
68Clumsiness (HP:0002312)1.93846081
69Decreased circulating renin level (HP:0003351)1.91772054
70Decreased central vision (HP:0007663)1.91301305
71Acute encephalopathy (HP:0006846)1.91080079
72Rib fusion (HP:0000902)1.90889812
73Genetic anticipation (HP:0003743)1.90301990
74Progressive inability to walk (HP:0002505)1.89615305
75Abnormal mitochondria in muscle tissue (HP:0008316)1.88009141
76Progressive macrocephaly (HP:0004481)1.85215513
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.83399450
78Furrowed tongue (HP:0000221)1.80904768
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.80162594
80Hepatic necrosis (HP:0002605)1.79736720
81Optic disc pallor (HP:0000543)1.79691567
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.79338824
83Male pseudohermaphroditism (HP:0000037)1.78265497
84Genital tract atresia (HP:0001827)1.78115006
85Ectopic kidney (HP:0000086)1.77526012
86Concave nail (HP:0001598)1.76677435
87Ketoacidosis (HP:0001993)1.75502167
88Abnormality of DNA repair (HP:0003254)1.73145469
89Abnormal urine output (HP:0012590)1.73096874
90Progressive cerebellar ataxia (HP:0002073)1.72997494
91Hemiparesis (HP:0001269)1.71279515
92Vaginal atresia (HP:0000148)1.70189001
93Renal cortical cysts (HP:0000803)1.69700506
94Abnormal ciliary motility (HP:0012262)1.67711663
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67606364
96Preaxial hand polydactyly (HP:0001177)1.66296775
97Aplasia/hypoplasia of the uterus (HP:0008684)1.66087707
98Thyroid-stimulating hormone excess (HP:0002925)1.64337886
99Abnormality of the ileum (HP:0001549)1.63798205
100Abnormal respiratory epithelium morphology (HP:0012253)1.63791257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.78336405
2ZAK3.51416875
3TLK13.27797056
4ADRBK23.17588837
5BMPR1B2.97876285
6PINK12.96029370
7MAP4K22.79270990
8GRK12.70639918
9ACVR1B2.49966370
10TAOK32.17041574
11WNK32.14554398
12CASK2.01890266
13MAPK132.00475352
14WNK41.97107174
15INSRR1.79507226
16NUAK11.77026844
17MAP3K41.74760101
18STK391.35884216
19MAP2K61.33752428
20OXSR11.26337165
21MAPKAPK31.23749463
22ADRBK11.18597799
23PHKG21.16578376
24PHKG11.16578376
25MAP2K71.12291784
26VRK11.11127029
27DAPK21.09753902
28MARK11.09730998
29MAPK151.08948909
30PRKCG1.06466473
31CAMKK21.04179163
32PAK31.03381873
33BCKDK0.99835825
34FGFR20.99634368
35DYRK20.94976523
36PRKCI0.94209296
37MKNK20.93023390
38PDK20.90254863
39MUSK0.86157867
40TRIM280.84443039
41TNIK0.83716547
42TNK20.83130112
43NTRK30.81766817
44AKT30.80429002
45PRKCE0.79502212
46RPS6KA50.77388563
47SIK20.76917952
48PNCK0.76856681
49PKN10.76380854
50FLT30.76284096
51IKBKB0.75069830
52TEC0.74564305
53STK110.73499652
54CSNK1G20.71076405
55CAMK10.68454000
56PRKCQ0.67532402
57TGFBR10.67162699
58TXK0.66867001
59KIT0.66788502
60NME10.65540928
61PTK2B0.65236322
62CSNK1G10.62996552
63CSNK1G30.58707650
64PRKAA10.57102558
65PLK20.56612711
66TIE10.56441265
67STK160.55238709
68PRKAA20.54915849
69PRKCZ0.51928599
70MAP2K40.51059634
71CSNK1A1L0.50921969
72RPS6KA60.50565118
73NTRK20.50366420
74CSNK1A10.48184109
75MAP4K10.46243994
76NLK0.45651115
77PRKACA0.45530183
78CDK80.45077716
79MAPKAPK50.44822339
80CHUK0.44642959
81PRKD20.44250924
82CHEK20.44144331
83STK38L0.43396623
84EPHA40.43369824
85IRAK10.41489159
86CAMK2A0.40429633
87PIK3CA0.39944085
88EPHA30.39209611
89ATR0.38465041
90PIM10.38411779
91MAP3K70.38287086
92ITK0.36519174
93BRSK20.35961588
94MAP2K20.34600000
95RPS6KB10.34512437
96CCNB10.34497688
97MARK30.33801021
98TAF10.33007568
99PRKCH0.32810386
100PRKCA0.32502092

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78771344
2Phototransduction_Homo sapiens_hsa047442.75195923
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.63641952
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52997041
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29194397
6Linoleic acid metabolism_Homo sapiens_hsa005912.28252955
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26275769
8Homologous recombination_Homo sapiens_hsa034402.23662125
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.20169386
10Selenocompound metabolism_Homo sapiens_hsa004502.18328537
11Nitrogen metabolism_Homo sapiens_hsa009102.14003389
12RNA polymerase_Homo sapiens_hsa030202.12856504
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11088332
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01655428
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.99868100
16Fanconi anemia pathway_Homo sapiens_hsa034601.97511372
17Basal transcription factors_Homo sapiens_hsa030221.92351739
18Nicotine addiction_Homo sapiens_hsa050331.91017761
19Butanoate metabolism_Homo sapiens_hsa006501.90620941
20Oxidative phosphorylation_Homo sapiens_hsa001901.85923764
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80160495
22Ether lipid metabolism_Homo sapiens_hsa005651.78573090
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63054419
24Caffeine metabolism_Homo sapiens_hsa002321.62665269
25Tryptophan metabolism_Homo sapiens_hsa003801.62026610
26Taste transduction_Homo sapiens_hsa047421.40968325
27RNA degradation_Homo sapiens_hsa030181.40091475
28Parkinsons disease_Homo sapiens_hsa050121.30318722
29One carbon pool by folate_Homo sapiens_hsa006701.28116804
30ABC transporters_Homo sapiens_hsa020101.24407810
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.21934601
32Sulfur relay system_Homo sapiens_hsa041221.20014541
33Morphine addiction_Homo sapiens_hsa050321.19613670
34Olfactory transduction_Homo sapiens_hsa047401.18747498
35Peroxisome_Homo sapiens_hsa041461.17188749
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16464458
37Insulin secretion_Homo sapiens_hsa049111.13325762
38Chemical carcinogenesis_Homo sapiens_hsa052041.12219195
39Collecting duct acid secretion_Homo sapiens_hsa049661.09102542
40Primary immunodeficiency_Homo sapiens_hsa053401.09032410
41Glycerolipid metabolism_Homo sapiens_hsa005611.05156244
42Sulfur metabolism_Homo sapiens_hsa009201.04315288
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01105383
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.97648984
45Huntingtons disease_Homo sapiens_hsa050160.95156797
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94861053
47Regulation of autophagy_Homo sapiens_hsa041400.89702029
48Dorso-ventral axis formation_Homo sapiens_hsa043200.88793530
49Circadian entrainment_Homo sapiens_hsa047130.88555559
50Glutamatergic synapse_Homo sapiens_hsa047240.88026172
51Protein export_Homo sapiens_hsa030600.87451358
52Arachidonic acid metabolism_Homo sapiens_hsa005900.86219785
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86217269
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85771099
55Ovarian steroidogenesis_Homo sapiens_hsa049130.84218898
56Serotonergic synapse_Homo sapiens_hsa047260.81881442
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.79193168
58Alzheimers disease_Homo sapiens_hsa050100.78575976
59Retinol metabolism_Homo sapiens_hsa008300.78474796
60Purine metabolism_Homo sapiens_hsa002300.76195304
61Propanoate metabolism_Homo sapiens_hsa006400.75188871
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74991788
63Pyrimidine metabolism_Homo sapiens_hsa002400.74961459
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72397779
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.70594523
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70338209
67Calcium signaling pathway_Homo sapiens_hsa040200.69162678
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68135499
69Cardiac muscle contraction_Homo sapiens_hsa042600.66040202
70GABAergic synapse_Homo sapiens_hsa047270.65780205
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64988200
72Metabolic pathways_Homo sapiens_hsa011000.64901884
73Non-homologous end-joining_Homo sapiens_hsa034500.64148015
74beta-Alanine metabolism_Homo sapiens_hsa004100.63893029
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63068097
76Salivary secretion_Homo sapiens_hsa049700.57532489
77Cocaine addiction_Homo sapiens_hsa050300.53201008
78Fat digestion and absorption_Homo sapiens_hsa049750.52239583
79Vitamin digestion and absorption_Homo sapiens_hsa049770.50713349
80Systemic lupus erythematosus_Homo sapiens_hsa053220.49235503
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48110698
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48006590
83Lysine degradation_Homo sapiens_hsa003100.46921026
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.44728489
85Dopaminergic synapse_Homo sapiens_hsa047280.43516534
86Long-term depression_Homo sapiens_hsa047300.43288876
87Nucleotide excision repair_Homo sapiens_hsa034200.42772119
88Hedgehog signaling pathway_Homo sapiens_hsa043400.41980594
89Basal cell carcinoma_Homo sapiens_hsa052170.41269462
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40064160
91Cholinergic synapse_Homo sapiens_hsa047250.39869974
92Histidine metabolism_Homo sapiens_hsa003400.39798458
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.39757646
94Alcoholism_Homo sapiens_hsa050340.39348309
95Asthma_Homo sapiens_hsa053100.38350170
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36798459
97cAMP signaling pathway_Homo sapiens_hsa040240.36686788
98Renin secretion_Homo sapiens_hsa049240.35434216
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33188660
100Base excision repair_Homo sapiens_hsa034100.32399527

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