ZNF492

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.56983999
2fucose catabolic process (GO:0019317)4.38535601
3L-fucose metabolic process (GO:0042354)4.38535601
4L-fucose catabolic process (GO:0042355)4.38535601
5piRNA metabolic process (GO:0034587)4.22589044
6regulation of meiosis I (GO:0060631)3.89311693
7synapsis (GO:0007129)3.81306939
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.75844783
9DNA deamination (GO:0045006)3.75684148
10water-soluble vitamin biosynthetic process (GO:0042364)3.59137199
11response to pheromone (GO:0019236)3.40314471
12protein-cofactor linkage (GO:0018065)3.40184137
13protein K6-linked ubiquitination (GO:0085020)3.38584427
14indolalkylamine metabolic process (GO:0006586)3.38020585
15tryptophan catabolic process (GO:0006569)3.34798361
16indole-containing compound catabolic process (GO:0042436)3.34798361
17indolalkylamine catabolic process (GO:0046218)3.34798361
18kynurenine metabolic process (GO:0070189)3.33297404
19replication fork processing (GO:0031297)3.32439472
20reciprocal meiotic recombination (GO:0007131)3.24848813
21reciprocal DNA recombination (GO:0035825)3.24848813
22recombinational repair (GO:0000725)3.22857356
23double-strand break repair via homologous recombination (GO:0000724)3.21283185
24male meiosis I (GO:0007141)3.19836193
25meiotic chromosome segregation (GO:0045132)3.16174940
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.10808775
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.08403352
28cornea development in camera-type eye (GO:0061303)3.05905280
29RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01515523
30protein complex biogenesis (GO:0070271)2.99925831
31DNA double-strand break processing (GO:0000729)2.99908221
32tryptophan metabolic process (GO:0006568)2.98944482
33reflex (GO:0060004)2.98927861
34mitochondrial respiratory chain complex I assembly (GO:0032981)2.98522107
35NADH dehydrogenase complex assembly (GO:0010257)2.98522107
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98522107
37DNA methylation involved in gamete generation (GO:0043046)2.98302042
38neural tube formation (GO:0001841)2.95424454
39sulfation (GO:0051923)2.91594515
40platelet dense granule organization (GO:0060155)2.90812421
41regulation of DNA endoreduplication (GO:0032875)2.89972439
42positive regulation of meiosis (GO:0045836)2.86886909
43nonmotile primary cilium assembly (GO:0035058)2.86233430
44mitochondrial respiratory chain complex assembly (GO:0033108)2.85777141
45retinal cone cell development (GO:0046549)2.79185084
46respiratory chain complex IV assembly (GO:0008535)2.78179292
47photoreceptor cell maintenance (GO:0045494)2.74933113
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74208609
49regulation of hippo signaling (GO:0035330)2.73989122
50limb bud formation (GO:0060174)2.73277637
51axoneme assembly (GO:0035082)2.72604191
52negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72262487
53negative regulation of telomere maintenance (GO:0032205)2.71853761
54male meiosis (GO:0007140)2.70734216
55preassembly of GPI anchor in ER membrane (GO:0016254)2.70536119
56positive regulation of meiotic cell cycle (GO:0051446)2.69202331
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68970399
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68970399
59negative regulation of mast cell activation (GO:0033004)2.68693512
60resolution of meiotic recombination intermediates (GO:0000712)2.68469642
61detection of light stimulus involved in sensory perception (GO:0050962)2.68294646
62detection of light stimulus involved in visual perception (GO:0050908)2.68294646
63indole-containing compound metabolic process (GO:0042430)2.65671765
64cell proliferation in forebrain (GO:0021846)2.65412986
65epithelial cilium movement (GO:0003351)2.63567425
66behavioral response to ethanol (GO:0048149)2.61845223
67cellular response to ATP (GO:0071318)2.61794519
68photoreceptor cell development (GO:0042461)2.60049807
69nephron epithelium morphogenesis (GO:0072088)2.59107793
70nephron tubule morphogenesis (GO:0072078)2.59107793
71cilium morphogenesis (GO:0060271)2.58876022
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.58799721
73meiosis I (GO:0007127)2.58544615
74negative regulation of systemic arterial blood pressure (GO:0003085)2.56309646
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55488580
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.54603749
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54603749
78auditory receptor cell stereocilium organization (GO:0060088)2.54476966
79centriole replication (GO:0007099)2.53250890
80protein polyglutamylation (GO:0018095)2.51394169
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50468674
82rhodopsin mediated signaling pathway (GO:0016056)2.50117168
83cytochrome complex assembly (GO:0017004)2.49750726
84histone H2A acetylation (GO:0043968)2.49467761
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48827527
86hindbrain development (GO:0030902)2.48361451
87protein K11-linked deubiquitination (GO:0035871)2.45363633
88somite development (GO:0061053)2.44861939
89regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44379220
90regulation of action potential (GO:0098900)2.44177028
91cilium organization (GO:0044782)2.41780562
92primary amino compound metabolic process (GO:1901160)2.41300765
93regulation of male gonad development (GO:2000018)2.40877128
94negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.40683135
95pseudouridine synthesis (GO:0001522)2.40165310
96embryonic epithelial tube formation (GO:0001838)2.39494624
97negative regulation by host of viral transcription (GO:0043922)2.38918014
98regulation of mesoderm development (GO:2000380)2.38425030
99gamma-aminobutyric acid transport (GO:0015812)2.38340108
100isotype switching (GO:0045190)2.38173747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.07658788
2VDR_22108803_ChIP-Seq_LS180_Human3.62634895
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76357574
4GBX2_23144817_ChIP-Seq_PC3_Human2.72382214
5IGF1R_20145208_ChIP-Seq_DFB_Human2.62489387
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56055893
7EWS_26573619_Chip-Seq_HEK293_Human2.55141220
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51718438
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48370938
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.43655117
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40983908
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38840089
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35214411
14FUS_26573619_Chip-Seq_HEK293_Human2.33562849
15EZH2_22144423_ChIP-Seq_EOC_Human2.29942098
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27172140
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.14283342
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07641446
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.05070876
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.01520825
21* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00517704
22P300_19829295_ChIP-Seq_ESCs_Human1.99394718
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.97136822
24IRF1_19129219_ChIP-ChIP_H3396_Human1.96228084
25TAF15_26573619_Chip-Seq_HEK293_Human1.95784828
26ER_23166858_ChIP-Seq_MCF-7_Human1.94716286
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93729622
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88572846
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83931936
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76481109
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69417078
32BCAT_22108803_ChIP-Seq_LS180_Human1.66205576
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62679526
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57697312
35ELK1_19687146_ChIP-ChIP_HELA_Human1.57444309
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54559632
37TP53_22573176_ChIP-Seq_HFKS_Human1.52852060
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51811016
39MYC_18940864_ChIP-ChIP_HL60_Human1.50174634
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48020567
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40754159
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.40497862
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40460880
44CBP_20019798_ChIP-Seq_JUKART_Human1.40460880
45VDR_23849224_ChIP-Seq_CD4+_Human1.40228811
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39683028
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.39683028
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38689201
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37288706
50STAT3_23295773_ChIP-Seq_U87_Human1.36086307
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35561048
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.34802572
53NANOG_19829295_ChIP-Seq_ESCs_Human1.34288529
54SOX2_19829295_ChIP-Seq_ESCs_Human1.34288529
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34187976
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33959675
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.31533310
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31244471
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31185096
60RNF2_27304074_Chip-Seq_NSC_Mouse1.30423102
61SMAD4_21799915_ChIP-Seq_A2780_Human1.29232934
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28348139
63AR_25329375_ChIP-Seq_VCAP_Human1.28282658
64TCF4_23295773_ChIP-Seq_U87_Human1.28059637
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27881708
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.24846922
67TCF4_22108803_ChIP-Seq_LS180_Human1.23725108
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19152700
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18928391
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18928391
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.18877764
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17903206
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17750348
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.17280738
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.16851684
76AR_21572438_ChIP-Seq_LNCaP_Human1.13896062
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13210940
78NCOR_22424771_ChIP-Seq_293T_Human1.12119762
79AR_20517297_ChIP-Seq_VCAP_Human1.11903871
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.11040054
81RUNX2_22187159_ChIP-Seq_PCA_Human1.09630081
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08915529
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.08466176
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07778174
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06841000
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04441134
87* HOXB7_26014856_ChIP-Seq_BT474_Human1.04333563
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.04293793
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00988303
90REST_21632747_ChIP-Seq_MESCs_Mouse0.98241435
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.97526028
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96175442
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96036642
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.96024635
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95493200
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94017854
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.93741923
98CDX2_22108803_ChIP-Seq_LS180_Human0.93434113
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.93107906
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92598614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.98377204
2MP0002102_abnormal_ear_morphology2.70797951
3MP0005551_abnormal_eye_electrophysiolog2.55315585
4MP0003136_yellow_coat_color2.39093333
5MP0001485_abnormal_pinna_reflex2.32853731
6MP0001968_abnormal_touch/_nociception2.31756048
7MP0006292_abnormal_olfactory_placode2.28691438
8MP0004885_abnormal_endolymph2.27651252
9MP0003195_calcinosis2.18595993
10MP0008872_abnormal_physiological_respon2.15557335
11MP0002837_dystrophic_cardiac_calcinosis2.11938530
12MP0005084_abnormal_gallbladder_morpholo2.03753421
13MP0001986_abnormal_taste_sensitivity2.03261742
14MP0002736_abnormal_nociception_after1.99545355
15MP0004147_increased_porphyrin_level1.97690528
16MP0006072_abnormal_retinal_apoptosis1.97383271
17MP0003011_delayed_dark_adaptation1.97279654
18MP0002876_abnormal_thyroid_physiology1.94861847
19MP0000569_abnormal_digit_pigmentation1.89670200
20MP0002160_abnormal_reproductive_system1.82139945
21MP0002638_abnormal_pupillary_reflex1.80310913
22MP0005253_abnormal_eye_physiology1.78460334
23MP0005646_abnormal_pituitary_gland1.76136400
24MP0003646_muscle_fatigue1.72953840
25MP0000372_irregular_coat_pigmentation1.72274016
26MP0004742_abnormal_vestibular_system1.71541130
27MP0002938_white_spotting1.70364698
28MP0010094_abnormal_chromosome_stability1.69215989
29MP0000631_abnormal_neuroendocrine_gland1.66437516
30MP0002653_abnormal_ependyma_morphology1.64785082
31MP0005645_abnormal_hypothalamus_physiol1.63363506
32MP0009745_abnormal_behavioral_response1.60898855
33MP0005389_reproductive_system_phenotype1.60271249
34MP0010386_abnormal_urinary_bladder1.58159894
35MP0000427_abnormal_hair_cycle1.51432495
36MP0008058_abnormal_DNA_repair1.49091699
37MP0008875_abnormal_xenobiotic_pharmacok1.46505130
38MP0003880_abnormal_central_pattern1.44055543
39MP0001529_abnormal_vocalization1.43878147
40MP0002138_abnormal_hepatobiliary_system1.42883097
41MP0003718_maternal_effect1.40801298
42MP0002735_abnormal_chemical_nociception1.38612081
43MP0004142_abnormal_muscle_tone1.38505828
44MP0002751_abnormal_autonomic_nervous1.38224234
45MP0004133_heterotaxia1.35709691
46MP0002272_abnormal_nervous_system1.33645717
47MP0003890_abnormal_embryonic-extraembry1.32843112
48MP0001919_abnormal_reproductive_system1.31143986
49MP0002928_abnormal_bile_duct1.30914524
50MP0002163_abnormal_gland_morphology1.28924387
51MP0009046_muscle_twitch1.28114619
52MP0001501_abnormal_sleep_pattern1.28105079
53MP0005174_abnormal_tail_pigmentation1.25261427
54MP0001486_abnormal_startle_reflex1.19813078
55MP0005377_hearing/vestibular/ear_phenot1.18058126
56MP0003878_abnormal_ear_physiology1.18058126
57MP0002210_abnormal_sex_determination1.16361834
58MP0002277_abnormal_respiratory_mucosa1.16278451
59MP0004215_abnormal_myocardial_fiber1.11483096
60MP0001929_abnormal_gametogenesis1.09994902
61MP0003693_abnormal_embryo_hatching1.09557920
62MP0005379_endocrine/exocrine_gland_phen1.04939191
63MP0000383_abnormal_hair_follicle1.04737344
64MP0005171_absent_coat_pigmentation1.02769879
65MP0000049_abnormal_middle_ear1.00597249
66MP0004043_abnormal_pH_regulation0.99978321
67MP0005195_abnormal_posterior_eye0.99590232
68MP0003787_abnormal_imprinting0.98529221
69MP0001145_abnormal_male_reproductive0.98444583
70MP0004145_abnormal_muscle_electrophysio0.97456511
71MP0000653_abnormal_sex_gland0.97118074
72MP0000026_abnormal_inner_ear0.96933627
73MP0003698_abnormal_male_reproductive0.96848228
74MP0002064_seizures0.96098045
75MP0005367_renal/urinary_system_phenotyp0.94728054
76MP0000516_abnormal_urinary_system0.94728054
77MP0002095_abnormal_skin_pigmentation0.94712563
78MP0003937_abnormal_limbs/digits/tail_de0.94406288
79MP0002067_abnormal_sensory_capabilities0.92065046
80MP0008775_abnormal_heart_ventricle0.90912643
81MP0001970_abnormal_pain_threshold0.89679637
82MP0003283_abnormal_digestive_organ0.89203602
83MP0002733_abnormal_thermal_nociception0.89049798
84MP0005386_behavior/neurological_phenoty0.88026266
85MP0004924_abnormal_behavior0.88026266
86MP0000647_abnormal_sebaceous_gland0.87693678
87MP0002184_abnormal_innervation0.87334981
88MP0005085_abnormal_gallbladder_physiolo0.87294367
89MP0000538_abnormal_urinary_bladder0.86578585
90MP0002572_abnormal_emotion/affect_behav0.86205364
91MP0006276_abnormal_autonomic_nervous0.85500005
92MP0008057_abnormal_DNA_replication0.84924380
93MP0002752_abnormal_somatic_nervous0.84703749
94MP0002557_abnormal_social/conspecific_i0.83518508
95MP0001963_abnormal_hearing_physiology0.83218428
96MP0002234_abnormal_pharynx_morphology0.82084246
97MP0008789_abnormal_olfactory_epithelium0.82017403
98MP0002734_abnormal_mechanical_nocicepti0.81864329
99MP0008995_early_reproductive_senescence0.81602387
100MP0001873_stomach_inflammation0.80174841

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.36564013
2Abnormality of midbrain morphology (HP:0002418)4.02483011
3Molar tooth sign on MRI (HP:0002419)4.02483011
4Pancreatic fibrosis (HP:0100732)4.01904885
5True hermaphroditism (HP:0010459)3.94902378
6Congenital stationary night blindness (HP:0007642)3.51290818
7Type II lissencephaly (HP:0007260)3.32986919
8Nephronophthisis (HP:0000090)3.31374683
9Attenuation of retinal blood vessels (HP:0007843)2.91321794
10Pendular nystagmus (HP:0012043)2.90913113
11Medial flaring of the eyebrow (HP:0010747)2.87092797
12Abnormality of the renal cortex (HP:0011035)2.85311990
13Chronic hepatic failure (HP:0100626)2.84457015
14Abnormality of the renal medulla (HP:0100957)2.80872003
15Abolished electroretinogram (ERG) (HP:0000550)2.77005508
16Cystic liver disease (HP:0006706)2.61170897
17Abnormal rod and cone electroretinograms (HP:0008323)2.48423657
18Sclerocornea (HP:0000647)2.48383560
19Aplasia/Hypoplasia of the tongue (HP:0010295)2.47130753
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.47001159
21Tubular atrophy (HP:0000092)2.45892019
22Abnormality of the ileum (HP:0001549)2.44047673
23Patellar aplasia (HP:0006443)2.43164309
24Stomach cancer (HP:0012126)2.39465039
25Meckel diverticulum (HP:0002245)2.38927508
26Congenital, generalized hypertrichosis (HP:0004540)2.37327233
27Aplasia/Hypoplasia of the patella (HP:0006498)2.37155128
28Keratoconus (HP:0000563)2.34412845
29Increased corneal curvature (HP:0100692)2.34412845
30Aplasia/Hypoplasia of the tibia (HP:0005772)2.33554781
31Concave nail (HP:0001598)2.32574541
32Abnormality of the labia minora (HP:0012880)2.31707475
33Gaze-evoked nystagmus (HP:0000640)2.25924194
34Volvulus (HP:0002580)2.25772702
35Hypoplasia of the pons (HP:0012110)2.24022583
36Abnormality of the pons (HP:0007361)2.23497756
37Anencephaly (HP:0002323)2.22123683
38Decreased central vision (HP:0007663)2.19335787
39Oligodactyly (hands) (HP:0001180)2.17659694
40Retinal dysplasia (HP:0007973)2.17161957
41Male pseudohermaphroditism (HP:0000037)2.16558045
42Congenital primary aphakia (HP:0007707)2.15939545
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14378513
44Renal cortical cysts (HP:0000803)2.13475862
45Optic nerve hypoplasia (HP:0000609)2.12766019
46Gait imbalance (HP:0002141)2.12705739
47Polydipsia (HP:0001959)2.12550631
48Abnormal drinking behavior (HP:0030082)2.12550631
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12463154
50Hypothermia (HP:0002045)2.12265690
51Cerebellar dysplasia (HP:0007033)2.11904535
52Congenital hepatic fibrosis (HP:0002612)2.10961440
53Postaxial foot polydactyly (HP:0001830)2.07717129
54Hyperventilation (HP:0002883)2.07686046
55Genital tract atresia (HP:0001827)2.07587131
56Small hand (HP:0200055)2.05784467
57Acute necrotizing encephalopathy (HP:0006965)2.04781298
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03825945
59Furrowed tongue (HP:0000221)2.03779157
60Abnormality of chromosome stability (HP:0003220)2.00914462
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00328888
62Chromsome breakage (HP:0040012)1.99692530
63Large for gestational age (HP:0001520)1.97281007
64Lissencephaly (HP:0001339)1.97098484
65Increased CSF lactate (HP:0002490)1.97029076
66Vaginal atresia (HP:0000148)1.95239158
67Nephrogenic diabetes insipidus (HP:0009806)1.95003524
68Progressive inability to walk (HP:0002505)1.94402216
69Absent thumb (HP:0009777)1.93778696
70Abnormality of B cell number (HP:0010975)1.93343449
71Short tibia (HP:0005736)1.93076374
72Aplasia/Hypoplasia of the spleen (HP:0010451)1.92971216
73Postaxial hand polydactyly (HP:0001162)1.92885656
74Ectopic kidney (HP:0000086)1.91236561
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91017708
76Abnormality of alanine metabolism (HP:0010916)1.91017708
77Hyperalaninemia (HP:0003348)1.91017708
78Mitochondrial inheritance (HP:0001427)1.90678334
79Clubbing of toes (HP:0100760)1.90320978
80Aplasia/hypoplasia of the uterus (HP:0008684)1.88034763
81Progressive macrocephaly (HP:0004481)1.86542280
82Birth length less than 3rd percentile (HP:0003561)1.86261241
83Sloping forehead (HP:0000340)1.85948292
84Septo-optic dysplasia (HP:0100842)1.84998333
85Abnormality of the preputium (HP:0100587)1.84532824
86Inability to walk (HP:0002540)1.82248412
87Astigmatism (HP:0000483)1.80738995
883-Methylglutaconic aciduria (HP:0003535)1.80164832
89Lipid accumulation in hepatocytes (HP:0006561)1.79843873
90Preaxial hand polydactyly (HP:0001177)1.79334876
91Intestinal atresia (HP:0011100)1.78935589
92Progressive cerebellar ataxia (HP:0002073)1.77889095
93Bony spicule pigmentary retinopathy (HP:0007737)1.77622055
94Acute encephalopathy (HP:0006846)1.74184896
95Abnormal biliary tract physiology (HP:0012439)1.73269840
96Bile duct proliferation (HP:0001408)1.73269840
97Asplenia (HP:0001746)1.72017663
98Congenital sensorineural hearing impairment (HP:0008527)1.71459643
99Polyuria (HP:0000103)1.71231922
100Chorioretinal atrophy (HP:0000533)1.69329406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.15798080
2BMPR1B4.10385526
3ACVR1B3.16891225
4ADRBK23.00249275
5WNK32.77597087
6PNCK2.60153152
7ZAK2.55166483
8TLK12.37132112
9GRK12.11124892
10MAP4K22.09694255
11NUAK11.98809549
12CASK1.98052006
13MKNK21.96920474
14TSSK61.84790668
15PINK11.84483535
16TGFBR11.82367542
17WNK41.79590221
18STK391.59762717
19INSRR1.56240615
20VRK11.44090089
21WEE11.42028314
22OXSR11.40769866
23PLK41.36545287
24MAPK151.36167326
25MAPK131.35049841
26FGFR21.34893014
27TNIK1.25688100
28MAP3K41.16038177
29TAOK31.12646261
30CDK81.12557008
31BRSK21.06906534
32EIF2AK31.05154939
33MKNK11.03796976
34PLK31.03220852
35PRKCE1.00838133
36BUB11.00022513
37ADRBK10.97215411
38DAPK20.96223219
39TXK0.93222039
40BCKDK0.92627479
41CAMKK20.87869354
42CDC70.87098110
43TIE10.85424473
44DYRK20.84763460
45TAF10.84339965
46MST40.84013283
47PRKCG0.83504695
48PLK20.81639197
49PAK30.79433943
50MAP2K60.75686516
51CSNK1G10.74922007
52TRIM280.73343107
53CCNB10.72890143
54PKN10.72048576
55RPS6KA50.70576888
56CSNK1G20.70494274
57PIK3CA0.69273084
58EPHA40.66439397
59IRAK10.66373967
60ATR0.65647483
61TEC0.64967811
62PLK10.64289888
63CHEK20.62880829
64STK38L0.61812829
65MUSK0.61595245
66VRK20.58455344
67CSNK1G30.55145979
68NTRK20.54585417
69PASK0.52477896
70NME10.52476573
71MAPKAPK50.52402953
72NTRK30.50795653
73STK30.47138454
74ATM0.46872468
75MAP2K70.46742418
76CSNK1A10.46609401
77IKBKB0.45883765
78PRKCI0.45823360
79PTK2B0.45088211
80CAMK2A0.44970268
81TTK0.43538399
82ERBB30.43508680
83CDK30.42331776
84PRKCQ0.41328518
85PRKACA0.41137408
86CAMK10.40675871
87SRPK10.39232680
88RPS6KA40.39135124
89NLK0.38697537
90CSNK1A1L0.38563068
91STK110.38265603
92MARK10.37341392
93MAPKAPK30.36648291
94PHKG10.35924402
95PHKG20.35924402
96CSNK1D0.33869388
97AURKB0.33699339
98ERBB20.32231957
99CSNK2A10.31214480
100NEK10.30944619

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.85497434
2Phototransduction_Homo sapiens_hsa047442.84217338
3Fanconi anemia pathway_Homo sapiens_hsa034602.57384061
4Nitrogen metabolism_Homo sapiens_hsa009102.42793855
5Basal transcription factors_Homo sapiens_hsa030222.30075180
6One carbon pool by folate_Homo sapiens_hsa006702.18809392
7Oxidative phosphorylation_Homo sapiens_hsa001902.14606310
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14121516
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.12670296
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11800437
11Selenocompound metabolism_Homo sapiens_hsa004502.11219380
12Protein export_Homo sapiens_hsa030602.11058861
13Linoleic acid metabolism_Homo sapiens_hsa005912.10572720
14RNA polymerase_Homo sapiens_hsa030202.05176906
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92548664
16Caffeine metabolism_Homo sapiens_hsa002321.88851057
17Butanoate metabolism_Homo sapiens_hsa006501.88477248
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87981840
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86190990
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85489553
21Nicotine addiction_Homo sapiens_hsa050331.85385838
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73618924
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68741545
24Non-homologous end-joining_Homo sapiens_hsa034501.60719913
25RNA degradation_Homo sapiens_hsa030181.55994986
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52958470
27Tryptophan metabolism_Homo sapiens_hsa003801.50927792
28Parkinsons disease_Homo sapiens_hsa050121.49472427
29Ether lipid metabolism_Homo sapiens_hsa005651.45846838
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35355720
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27831933
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.26494612
33Taste transduction_Homo sapiens_hsa047421.21549390
34Huntingtons disease_Homo sapiens_hsa050161.14074468
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13663560
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08833050
37Propanoate metabolism_Homo sapiens_hsa006401.08134387
38Primary immunodeficiency_Homo sapiens_hsa053401.07939432
39Mismatch repair_Homo sapiens_hsa034301.07226655
40Chemical carcinogenesis_Homo sapiens_hsa052041.06285301
41Regulation of autophagy_Homo sapiens_hsa041401.02272159
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01825608
43Olfactory transduction_Homo sapiens_hsa047400.99882220
44Retinol metabolism_Homo sapiens_hsa008300.98826394
45Nucleotide excision repair_Homo sapiens_hsa034200.88098165
46Morphine addiction_Homo sapiens_hsa050320.87036024
47Dorso-ventral axis formation_Homo sapiens_hsa043200.85897681
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84058894
49DNA replication_Homo sapiens_hsa030300.83050146
50Alzheimers disease_Homo sapiens_hsa050100.82682460
51Proteasome_Homo sapiens_hsa030500.82556278
52Steroid biosynthesis_Homo sapiens_hsa001000.81618400
53RNA transport_Homo sapiens_hsa030130.80667610
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80364624
55ABC transporters_Homo sapiens_hsa020100.79736312
56Cardiac muscle contraction_Homo sapiens_hsa042600.79509662
57Collecting duct acid secretion_Homo sapiens_hsa049660.79205004
58Peroxisome_Homo sapiens_hsa041460.79020632
59Purine metabolism_Homo sapiens_hsa002300.78671992
60Pyrimidine metabolism_Homo sapiens_hsa002400.78582771
61Insulin secretion_Homo sapiens_hsa049110.75380010
62Vitamin digestion and absorption_Homo sapiens_hsa049770.75289725
63Arachidonic acid metabolism_Homo sapiens_hsa005900.74100073
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.73388615
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73187321
66beta-Alanine metabolism_Homo sapiens_hsa004100.70795595
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.68968278
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67187912
69GABAergic synapse_Homo sapiens_hsa047270.66299618
70Glycerolipid metabolism_Homo sapiens_hsa005610.65886043
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62539913
72Serotonergic synapse_Homo sapiens_hsa047260.62469196
73Folate biosynthesis_Homo sapiens_hsa007900.60252632
74Glutamatergic synapse_Homo sapiens_hsa047240.59193582
75Ribosome_Homo sapiens_hsa030100.58293348
76Circadian entrainment_Homo sapiens_hsa047130.57319885
77Metabolic pathways_Homo sapiens_hsa011000.57078277
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.56672954
79Histidine metabolism_Homo sapiens_hsa003400.55919415
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55810613
81Calcium signaling pathway_Homo sapiens_hsa040200.54921054
82Hedgehog signaling pathway_Homo sapiens_hsa043400.54756952
83Vitamin B6 metabolism_Homo sapiens_hsa007500.54491966
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52325410
85TGF-beta signaling pathway_Homo sapiens_hsa043500.52322911
86Ovarian steroidogenesis_Homo sapiens_hsa049130.51761052
87Base excision repair_Homo sapiens_hsa034100.51596688
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51577302
89Sulfur metabolism_Homo sapiens_hsa009200.50927924
90Spliceosome_Homo sapiens_hsa030400.49320531
91p53 signaling pathway_Homo sapiens_hsa041150.49068616
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47816283
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46430690
94Systemic lupus erythematosus_Homo sapiens_hsa053220.45631950
95Mineral absorption_Homo sapiens_hsa049780.44163533
96Salivary secretion_Homo sapiens_hsa049700.40938332
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39011137
98Fat digestion and absorption_Homo sapiens_hsa049750.37997502
99Basal cell carcinoma_Homo sapiens_hsa052170.36819569
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36272604

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