ZNF487

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.80910756
2epithelial cilium movement (GO:0003351)5.76576036
3axonemal dynein complex assembly (GO:0070286)5.63845392
4cilium movement (GO:0003341)5.38274896
5cilium or flagellum-dependent cell motility (GO:0001539)4.58180266
6platelet dense granule organization (GO:0060155)4.44861433
7regulation of cilium movement (GO:0003352)4.42706456
8axoneme assembly (GO:0035082)4.37505178
9protein localization to cilium (GO:0061512)4.28241963
10preassembly of GPI anchor in ER membrane (GO:0016254)4.14242150
11adaptation of signaling pathway (GO:0023058)4.04297373
12behavioral response to nicotine (GO:0035095)3.95979000
13DNA deamination (GO:0045006)3.89679426
14intraciliary transport (GO:0042073)3.86077925
15neural tube formation (GO:0001841)3.82315316
16response to pheromone (GO:0019236)3.81178108
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.67720308
18L-fucose metabolic process (GO:0042354)3.62199766
19L-fucose catabolic process (GO:0042355)3.62199766
20fucose catabolic process (GO:0019317)3.62199766
21GPI anchor metabolic process (GO:0006505)3.53087929
22respiratory chain complex IV assembly (GO:0008535)3.51902327
23retinal cone cell development (GO:0046549)3.51635207
24protein polyglutamylation (GO:0018095)3.49995883
25cilium organization (GO:0044782)3.47397870
26motile cilium assembly (GO:0044458)3.42443414
27cilium assembly (GO:0042384)3.37222977
28cilium morphogenesis (GO:0060271)3.33599971
29sperm motility (GO:0030317)3.32679527
30centriole replication (GO:0007099)3.32042840
31negative regulation of oligodendrocyte differentiation (GO:0048715)3.31875307
32regulation of neurotransmitter uptake (GO:0051580)3.29856618
33GPI anchor biosynthetic process (GO:0006506)3.23367101
34photoreceptor cell maintenance (GO:0045494)3.22605127
35multicellular organism reproduction (GO:0032504)3.19724635
36cell wall macromolecule catabolic process (GO:0016998)3.13763495
37indolalkylamine metabolic process (GO:0006586)3.07978885
38cellular ketone body metabolic process (GO:0046950)3.06760912
39detection of light stimulus involved in visual perception (GO:0050908)3.02423341
40detection of light stimulus involved in sensory perception (GO:0050962)3.02423341
41keratinocyte development (GO:0003334)2.93800159
42indole-containing compound catabolic process (GO:0042436)2.88380795
43indolalkylamine catabolic process (GO:0046218)2.88380795
44tryptophan catabolic process (GO:0006569)2.88380795
45cytochrome complex assembly (GO:0017004)2.84430475
46C-terminal protein lipidation (GO:0006501)2.83953082
47negative regulation of transcription regulatory region DNA binding (GO:2000678)2.82528176
48ketone body metabolic process (GO:1902224)2.82155474
49C-terminal protein amino acid modification (GO:0018410)2.81899226
50sulfation (GO:0051923)2.81256008
51amine catabolic process (GO:0009310)2.81005827
52cellular biogenic amine catabolic process (GO:0042402)2.81005827
53gamma-aminobutyric acid transport (GO:0015812)2.80868599
54cell wall macromolecule metabolic process (GO:0044036)2.79268069
55mannosylation (GO:0097502)2.78380696
56ubiquinone biosynthetic process (GO:0006744)2.76518250
57nonmotile primary cilium assembly (GO:0035058)2.76068830
58protein complex biogenesis (GO:0070271)2.74240900
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.72998736
60NADH dehydrogenase complex assembly (GO:0010257)2.72998736
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72998736
62piRNA metabolic process (GO:0034587)2.72276387
63neuron fate determination (GO:0048664)2.69858822
64cytidine deamination (GO:0009972)2.67229442
65cytidine metabolic process (GO:0046087)2.67229442
66cytidine catabolic process (GO:0006216)2.67229442
67peptidyl-histidine modification (GO:0018202)2.66437471
68transmission of nerve impulse (GO:0019226)2.61707216
69positive regulation of oligodendrocyte differentiation (GO:0048714)2.61667925
70behavioral response to ethanol (GO:0048149)2.60286693
71regulation of microtubule-based movement (GO:0060632)2.60150469
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59132436
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59132436
74cellular component assembly involved in morphogenesis (GO:0010927)2.57961046
75central nervous system myelination (GO:0022010)2.55293257
76axon ensheathment in central nervous system (GO:0032291)2.55293257
77ubiquinone metabolic process (GO:0006743)2.54094915
78smoothened signaling pathway (GO:0007224)2.53570749
79proline transport (GO:0015824)2.52010144
80male meiosis (GO:0007140)2.50485202
81regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.50444513
82dopamine transport (GO:0015872)2.50118928
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49874145
84S-adenosylmethionine metabolic process (GO:0046500)2.48286627
85neuronal action potential (GO:0019228)2.47800937
86determination of left/right symmetry (GO:0007368)2.47646575
87regulation of oligodendrocyte differentiation (GO:0048713)2.47255547
88parental behavior (GO:0060746)2.47250469
89synaptic transmission, cholinergic (GO:0007271)2.45076916
90water-soluble vitamin biosynthetic process (GO:0042364)2.42634876
91left/right axis specification (GO:0070986)2.42344873
92glycolipid biosynthetic process (GO:0009247)2.42174106
93protein K11-linked deubiquitination (GO:0035871)2.41981001
94kynurenine metabolic process (GO:0070189)2.40942047
95exogenous drug catabolic process (GO:0042738)2.40779473
96mitochondrial respiratory chain complex assembly (GO:0033108)2.40503336
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.39976926
98protein-cofactor linkage (GO:0018065)2.37035005
99somite development (GO:0061053)2.36328209
100embryonic epithelial tube formation (GO:0001838)2.36160579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.54505619
2VDR_22108803_ChIP-Seq_LS180_Human3.35299072
3EZH2_22144423_ChIP-Seq_EOC_Human2.86186976
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70400723
5GBX2_23144817_ChIP-Seq_PC3_Human2.59104653
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44717699
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37579773
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33663193
9IGF1R_20145208_ChIP-Seq_DFB_Human2.31095789
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.29244716
11FUS_26573619_Chip-Seq_HEK293_Human2.25101329
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23743760
13P300_19829295_ChIP-Seq_ESCs_Human2.12296515
14EWS_26573619_Chip-Seq_HEK293_Human2.11947898
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10093584
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97377909
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90984625
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81242577
19ER_23166858_ChIP-Seq_MCF-7_Human1.79667366
20TAF15_26573619_Chip-Seq_HEK293_Human1.77068741
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76184921
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76085012
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75471402
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.70645408
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67325510
26BCAT_22108803_ChIP-Seq_LS180_Human1.66766107
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64499446
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.60673128
29CBP_20019798_ChIP-Seq_JUKART_Human1.54837482
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54837482
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52153692
32AR_25329375_ChIP-Seq_VCAP_Human1.51044247
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50843202
34NANOG_19829295_ChIP-Seq_ESCs_Human1.49281471
35SOX2_19829295_ChIP-Seq_ESCs_Human1.49281471
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.49012166
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48811050
38SMAD4_21799915_ChIP-Seq_A2780_Human1.48804200
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47155297
40STAT3_23295773_ChIP-Seq_U87_Human1.46965363
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46556099
42TP53_22573176_ChIP-Seq_HFKS_Human1.42089492
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.39052619
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38601195
45TCF4_22108803_ChIP-Seq_LS180_Human1.37695078
46TCF4_23295773_ChIP-Seq_U87_Human1.37510727
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.36073085
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36073085
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34711566
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34306795
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34306795
52* SMAD4_21741376_ChIP-Seq_EPCs_Human1.32778262
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32107132
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31886173
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.31814411
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.31586591
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31216141
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30759148
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30063608
60IRF1_19129219_ChIP-ChIP_H3396_Human1.28789894
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24504382
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.23001412
63RUNX2_22187159_ChIP-Seq_PCA_Human1.22576735
64* CDX2_22108803_ChIP-Seq_LS180_Human1.22453127
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.20793778
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20756115
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19048113
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18233572
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18143788
70ELK1_19687146_ChIP-ChIP_HELA_Human1.17965117
71AR_20517297_ChIP-Seq_VCAP_Human1.17758615
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17289851
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.17159003
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16542738
75RNF2_27304074_Chip-Seq_NSC_Mouse1.15662709
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15541843
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.14539419
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14360909
79MYC_18940864_ChIP-ChIP_HL60_Human1.12421184
80GATA3_26560356_Chip-Seq_TH2_Human1.10996524
81P53_22387025_ChIP-Seq_ESCs_Mouse1.10943176
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.10887260
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10404306
84NCOR_22424771_ChIP-Seq_293T_Human1.09617830
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09396214
86JUN_21703547_ChIP-Seq_K562_Human1.08874870
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08086475
88AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03895820
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03260827
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.02378949
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99959266
92* HOXB7_26014856_ChIP-Seq_BT474_Human0.99475161
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.99230797
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98952796
95AR_21572438_ChIP-Seq_LNCaP_Human0.98853132
96VDR_23849224_ChIP-Seq_CD4+_Human0.98698997
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98606494
98REST_21632747_ChIP-Seq_MESCs_Mouse0.98140535
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.97353714
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96612574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.95473560
2MP0003195_calcinosis2.67964205
3MP0003136_yellow_coat_color2.50907417
4MP0002102_abnormal_ear_morphology2.39626857
5MP0006292_abnormal_olfactory_placode2.39554633
6MP0005551_abnormal_eye_electrophysiolog2.33087129
7MP0003646_muscle_fatigue2.27688685
8MP0002653_abnormal_ependyma_morphology2.27450260
9MP0004043_abnormal_pH_regulation2.25264787
10MP0001986_abnormal_taste_sensitivity2.18724276
11MP0005645_abnormal_hypothalamus_physiol2.11516044
12MP0008875_abnormal_xenobiotic_pharmacok2.09093519
13MP0008872_abnormal_physiological_respon2.07950324
14MP0000569_abnormal_digit_pigmentation2.07007156
15MP0005174_abnormal_tail_pigmentation1.99120975
16MP0006072_abnormal_retinal_apoptosis1.97638866
17MP0008995_early_reproductive_senescence1.94273908
18MP0001968_abnormal_touch/_nociception1.87666741
19MP0003011_delayed_dark_adaptation1.85397843
20MP0005253_abnormal_eye_physiology1.78200753
21MP0000372_irregular_coat_pigmentation1.77871014
22MP0002638_abnormal_pupillary_reflex1.76874176
23MP0002163_abnormal_gland_morphology1.74806146
24MP0004885_abnormal_endolymph1.73836983
25MP0009046_muscle_twitch1.68869613
26MP0002876_abnormal_thyroid_physiology1.68466600
27MP0002736_abnormal_nociception_after1.66017639
28MP0002928_abnormal_bile_duct1.65757651
29MP0005410_abnormal_fertilization1.64309278
30MP0004142_abnormal_muscle_tone1.61921527
31MP0009745_abnormal_behavioral_response1.59484284
32MP0005646_abnormal_pituitary_gland1.58431184
33MP0001984_abnormal_olfaction1.58115289
34MP0002837_dystrophic_cardiac_calcinosis1.54747013
35MP0003878_abnormal_ear_physiology1.52643782
36MP0005377_hearing/vestibular/ear_phenot1.52643782
37MP0002234_abnormal_pharynx_morphology1.52374032
38MP0002272_abnormal_nervous_system1.51009224
39MP0002277_abnormal_respiratory_mucosa1.47652984
40MP0000631_abnormal_neuroendocrine_gland1.47192911
41MP0005084_abnormal_gallbladder_morpholo1.39242573
42MP0001486_abnormal_startle_reflex1.31937614
43MP0005367_renal/urinary_system_phenotyp1.31347055
44MP0000516_abnormal_urinary_system1.31347055
45MP0005379_endocrine/exocrine_gland_phen1.28480444
46MP0001485_abnormal_pinna_reflex1.26324820
47MP0000427_abnormal_hair_cycle1.24310571
48MP0001501_abnormal_sleep_pattern1.22748009
49MP0004133_heterotaxia1.22257995
50MP0005389_reproductive_system_phenotype1.22139469
51MP0008057_abnormal_DNA_replication1.19840648
52MP0001919_abnormal_reproductive_system1.16596148
53MP0009764_decreased_sensitivity_to1.16057576
54MP0010368_abnormal_lymphatic_system1.09655399
55MP0001764_abnormal_homeostasis1.09426389
56MP0002938_white_spotting1.09055839
57MP0001970_abnormal_pain_threshold1.08573004
58MP0000015_abnormal_ear_pigmentation1.08207285
59MP0003718_maternal_effect1.08158570
60MP0008789_abnormal_olfactory_epithelium1.06852947
61MP0005195_abnormal_posterior_eye1.02194311
62MP0001929_abnormal_gametogenesis1.01888844
63MP0002095_abnormal_skin_pigmentation1.00001523
64MP0002751_abnormal_autonomic_nervous0.99933143
65MP0004742_abnormal_vestibular_system0.99697186
66MP0002572_abnormal_emotion/affect_behav0.98107672
67MP0006276_abnormal_autonomic_nervous0.97976107
68MP0000026_abnormal_inner_ear0.94396122
69MP0003786_premature_aging0.93619482
70MP0002735_abnormal_chemical_nociception0.93072510
71MP0003698_abnormal_male_reproductive0.93007252
72MP0001905_abnormal_dopamine_level0.92587165
73MP0001324_abnormal_eye_pigmentation0.89240266
74MP0003724_increased_susceptibility_to0.88879892
75MP0005075_abnormal_melanosome_morpholog0.87144246
76MP0003880_abnormal_central_pattern0.86552303
77MP0004145_abnormal_muscle_electrophysio0.85279324
78MP0008058_abnormal_DNA_repair0.84593290
79MP0002160_abnormal_reproductive_system0.82296776
80MP0001293_anophthalmia0.81361100
81MP0002557_abnormal_social/conspecific_i0.80592855
82MP0002067_abnormal_sensory_capabilities0.79043046
83MP0002282_abnormal_trachea_morphology0.78322898
84MP0005671_abnormal_response_to0.78134233
85MP0001440_abnormal_grooming_behavior0.76562294
86MP0005085_abnormal_gallbladder_physiolo0.76548786
87MP0010386_abnormal_urinary_bladder0.76218041
88MP0000230_abnormal_systemic_arterial0.75998213
89MP0005167_abnormal_blood-brain_barrier0.75439118
90MP0001963_abnormal_hearing_physiology0.75106841
91MP0002229_neurodegeneration0.74548633
92MP0003787_abnormal_imprinting0.74047942
93MP0004147_increased_porphyrin_level0.73405851
94MP0002064_seizures0.72863485
95MP0002752_abnormal_somatic_nervous0.71945904
96MP0003122_maternal_imprinting0.71873945
97MP0001529_abnormal_vocalization0.70264608
98MP0005423_abnormal_somatic_nervous0.68662608
99MP0000653_abnormal_sex_gland0.66885066
100MP0004883_abnormal_blood_vessel0.66661824

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.02648560
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.91152368
3Absent/shortened dynein arms (HP:0200106)4.91152368
4True hermaphroditism (HP:0010459)4.65012259
5Abnormal respiratory motile cilium morphology (HP:0005938)4.53922338
6Abnormal respiratory epithelium morphology (HP:0012253)4.53922338
7Pancreatic cysts (HP:0001737)4.47781559
8Abnormal respiratory motile cilium physiology (HP:0012261)4.42122010
9Abnormal ciliary motility (HP:0012262)4.30152829
10Pancreatic fibrosis (HP:0100732)4.16204437
11Molar tooth sign on MRI (HP:0002419)3.78197115
12Abnormality of midbrain morphology (HP:0002418)3.78197115
13Rhinitis (HP:0012384)3.58082800
14Nephronophthisis (HP:0000090)3.49493896
15Tubulointerstitial nephritis (HP:0001970)3.39342871
16Medial flaring of the eyebrow (HP:0010747)3.27683643
17Chronic hepatic failure (HP:0100626)3.23805635
18Congenital stationary night blindness (HP:0007642)3.03276351
19Abnormality of the renal medulla (HP:0100957)2.93968520
20Congenital primary aphakia (HP:0007707)2.85932020
21Gait imbalance (HP:0002141)2.85734102
22Cystic liver disease (HP:0006706)2.79865820
23Chronic bronchitis (HP:0004469)2.76892251
24Bronchiectasis (HP:0002110)2.74920796
25Hyperventilation (HP:0002883)2.70234619
26Decreased central vision (HP:0007663)2.69552395
27Abnormal rod and cone electroretinograms (HP:0008323)2.67244798
28Nephrogenic diabetes insipidus (HP:0009806)2.63292395
29Male pseudohermaphroditism (HP:0000037)2.60615170
30Abnormality of the renal cortex (HP:0011035)2.54520853
31Sclerocornea (HP:0000647)2.50659263
32Abolished electroretinogram (ERG) (HP:0000550)2.49230012
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47368923
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.45048781
35Occipital encephalocele (HP:0002085)2.44982312
36Type II lissencephaly (HP:0007260)2.44878869
37Attenuation of retinal blood vessels (HP:0007843)2.36621050
38Large for gestational age (HP:0001520)2.33917923
39Concave nail (HP:0001598)2.33444561
40Tubular atrophy (HP:0000092)2.32064573
41Gaze-evoked nystagmus (HP:0000640)2.29199897
42Postaxial foot polydactyly (HP:0001830)2.28985776
43Genital tract atresia (HP:0001827)2.27651840
44Progressive cerebellar ataxia (HP:0002073)2.26180521
45Methylmalonic acidemia (HP:0002912)2.25285045
46Vaginal atresia (HP:0000148)2.24896971
47Inability to walk (HP:0002540)2.17311116
48Furrowed tongue (HP:0000221)2.17061858
49Stomach cancer (HP:0012126)2.16033937
50Abnormal drinking behavior (HP:0030082)2.13489280
51Polydipsia (HP:0001959)2.13489280
52Anencephaly (HP:0002323)2.09726778
53Abnormality of macular pigmentation (HP:0008002)2.06468027
54Chronic sinusitis (HP:0011109)2.03285194
55Congenital hepatic fibrosis (HP:0002612)2.02938114
56Acute necrotizing encephalopathy (HP:0006965)2.02028904
57Stomatitis (HP:0010280)2.00387005
58Renal cortical cysts (HP:0000803)1.96948854
59Bronchitis (HP:0012387)1.95673542
60Febrile seizures (HP:0002373)1.95248325
61Congenital, generalized hypertrichosis (HP:0004540)1.94761501
62Poor coordination (HP:0002370)1.94609872
63Hepatocellular necrosis (HP:0001404)1.93020970
64Postaxial hand polydactyly (HP:0001162)1.90494083
65Optic nerve hypoplasia (HP:0000609)1.89982091
66Progressive macrocephaly (HP:0004481)1.88217234
67Bile duct proliferation (HP:0001408)1.87957768
68Abnormal biliary tract physiology (HP:0012439)1.87957768
69Tubulointerstitial abnormality (HP:0001969)1.87487927
70Ketoacidosis (HP:0001993)1.85685196
71Acute encephalopathy (HP:0006846)1.84726575
72Mitochondrial inheritance (HP:0001427)1.84434471
73Keratoconus (HP:0000563)1.83491582
74Increased corneal curvature (HP:0100692)1.83491582
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.82300909
76Cerebellar dysplasia (HP:0007033)1.81783358
77Fair hair (HP:0002286)1.80822727
78Methylmalonic aciduria (HP:0012120)1.79641709
79Hepatic necrosis (HP:0002605)1.78135089
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77822362
81Bony spicule pigmentary retinopathy (HP:0007737)1.77497669
82Thyroiditis (HP:0100646)1.77186958
83Optic disc pallor (HP:0000543)1.76688798
84Hyperglycinemia (HP:0002154)1.74683347
85Increased CSF lactate (HP:0002490)1.73616637
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73540645
87Focal motor seizures (HP:0011153)1.73069367
88Septo-optic dysplasia (HP:0100842)1.72864023
89Broad-based gait (HP:0002136)1.71006150
90Clumsiness (HP:0002312)1.70441914
91Absent speech (HP:0001344)1.70214908
92Hypoproteinemia (HP:0003075)1.70194957
93Hemiparesis (HP:0001269)1.69537350
94Progressive inability to walk (HP:0002505)1.69361996
95Abnormal mitochondria in muscle tissue (HP:0008316)1.68410609
96Narrow forehead (HP:0000341)1.67397297
97Atonic seizures (HP:0010819)1.67038384
98Infertility (HP:0000789)1.66348830
99Retinitis pigmentosa (HP:0000510)1.65386673
100Polyuria (HP:0000103)1.64534202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.40125834
2ADRBK23.12246363
3MAP4K23.06651618
4WNK42.76451246
5MAPK132.45262197
6WNK32.35751378
7STK242.28174728
8BMPR1B2.27931317
9MAPK152.26564941
10TIE12.21548401
11GRK12.20036025
12STK392.19299500
13PINK12.17623406
14ZAK2.12169453
15INSRR2.10902325
16PNCK1.99811928
17NUAK11.85493107
18MST41.80154963
19CASK1.69792741
20TEC1.67147157
21TRIM281.48839515
22ACVR1B1.44251765
23TLK11.33357008
24TAOK31.24856053
25STK38L1.22679897
26MAP3K121.22001338
27WNK11.17758659
28MKNK21.12489718
29PAK31.11180930
30OXSR11.08807793
31PRKCE1.08746697
32VRK11.07025396
33BCR1.06798554
34TXK1.06660973
35MAPKAPK31.05340872
36MAP3K41.05103774
37ERBB31.02907395
38PRKCQ1.00032438
39ADRBK10.99208245
40PTK2B0.99034485
41AKT30.91842569
42KIT0.88965125
43PLK20.87784878
44PIK3CA0.87727387
45CSNK1G30.84585638
46CSNK1G20.83965704
47BMPR20.83927288
48CSNK1G10.81971131
49WEE10.79459030
50DYRK20.76997451
51NTRK30.76944001
52DAPK20.74680319
53TNIK0.74470189
54PRKCG0.73114161
55TNK20.69506998
56ITK0.67948664
57BCKDK0.67491046
58IKBKB0.66802636
59CSNK1A1L0.66517289
60PLK40.66423101
61EIF2AK30.64656982
62MAP3K20.62848856
63BRSK20.61247321
64MARK30.59897619
65GRK60.56603200
66TGFBR10.53575833
67PLK30.52997687
68MKNK10.52938210
69MAP2K70.51026302
70JAK30.47712514
71PRKACA0.46529704
72CCNB10.46525439
73SYK0.46410757
74IKBKE0.43907585
75EPHA40.43574567
76ABL10.42438342
77PKN10.39529802
78PIK3CG0.39480878
79PHKG10.39373716
80PHKG20.39373716
81DYRK30.39213782
82FGFR20.38652351
83CAMKK20.36788614
84EPHA30.36153288
85PRKCI0.36022692
86IGF1R0.35840280
87PRKCA0.35365034
88PRKG10.34344150
89VRK20.34202408
90CAMK2A0.34133990
91STK160.32333842
92LYN0.32158823
93STK30.31983816
94SGK20.31969332
95MINK10.31283933
96RPS6KA50.30563426
97FER0.30364666
98PRKCZ0.30239286
99DYRK1A0.28829500
100CSNK1A10.27770662

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.95322254
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65221604
3Protein export_Homo sapiens_hsa030602.64711182
4Phototransduction_Homo sapiens_hsa047442.45122899
5Nitrogen metabolism_Homo sapiens_hsa009102.30878512
6Asthma_Homo sapiens_hsa053102.14576774
7Oxidative phosphorylation_Homo sapiens_hsa001902.10359935
8Butanoate metabolism_Homo sapiens_hsa006502.04380635
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03000224
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.89995879
11Linoleic acid metabolism_Homo sapiens_hsa005911.89563236
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89358184
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.87349676
14Selenocompound metabolism_Homo sapiens_hsa004501.83932399
15Regulation of autophagy_Homo sapiens_hsa041401.78459340
16Propanoate metabolism_Homo sapiens_hsa006401.76848965
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73795591
18Allograft rejection_Homo sapiens_hsa053301.71199392
19Autoimmune thyroid disease_Homo sapiens_hsa053201.62373708
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59046706
21Parkinsons disease_Homo sapiens_hsa050121.56738674
22Graft-versus-host disease_Homo sapiens_hsa053321.56642363
23Basal transcription factors_Homo sapiens_hsa030221.56023565
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55836025
25Type I diabetes mellitus_Homo sapiens_hsa049401.55720474
26Peroxisome_Homo sapiens_hsa041461.55421523
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55239602
28Chemical carcinogenesis_Homo sapiens_hsa052041.53934949
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51656170
30Homologous recombination_Homo sapiens_hsa034401.51297808
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41596566
32Fanconi anemia pathway_Homo sapiens_hsa034601.39294456
33Olfactory transduction_Homo sapiens_hsa047401.36907595
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35356203
35Huntingtons disease_Homo sapiens_hsa050161.30913911
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30595959
37Caffeine metabolism_Homo sapiens_hsa002321.29221119
38Nicotine addiction_Homo sapiens_hsa050331.28158145
39Primary immunodeficiency_Homo sapiens_hsa053401.27054118
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26656533
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.22215640
42Collecting duct acid secretion_Homo sapiens_hsa049661.20967392
43Tryptophan metabolism_Homo sapiens_hsa003801.19937880
44Taste transduction_Homo sapiens_hsa047421.18401805
45Non-homologous end-joining_Homo sapiens_hsa034501.18259461
46Arachidonic acid metabolism_Homo sapiens_hsa005901.12972405
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11620909
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10112631
49Ether lipid metabolism_Homo sapiens_hsa005651.09626240
50Retinol metabolism_Homo sapiens_hsa008301.09458195
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.08580376
52RNA polymerase_Homo sapiens_hsa030201.04910468
53Morphine addiction_Homo sapiens_hsa050320.96952417
54Rheumatoid arthritis_Homo sapiens_hsa053230.95531122
55Proteasome_Homo sapiens_hsa030500.93115390
56Alzheimers disease_Homo sapiens_hsa050100.91990085
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91149118
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89919655
59beta-Alanine metabolism_Homo sapiens_hsa004100.87906429
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87596301
61Antigen processing and presentation_Homo sapiens_hsa046120.86262044
62Salivary secretion_Homo sapiens_hsa049700.84666734
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80542406
64RNA degradation_Homo sapiens_hsa030180.78065607
65ABC transporters_Homo sapiens_hsa020100.77429483
66Circadian entrainment_Homo sapiens_hsa047130.73448558
67Steroid biosynthesis_Homo sapiens_hsa001000.72050088
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70737458
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70626777
70Glutathione metabolism_Homo sapiens_hsa004800.68548048
71GABAergic synapse_Homo sapiens_hsa047270.68429546
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63818222
73Serotonergic synapse_Homo sapiens_hsa047260.63535272
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61118305
75Calcium signaling pathway_Homo sapiens_hsa040200.60195663
76Insulin secretion_Homo sapiens_hsa049110.58744488
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.57640150
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57032597
79Cardiac muscle contraction_Homo sapiens_hsa042600.56417122
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55988425
81Staphylococcus aureus infection_Homo sapiens_hsa051500.54860771
82Vitamin digestion and absorption_Homo sapiens_hsa049770.52911692
83African trypanosomiasis_Homo sapiens_hsa051430.52573515
84Purine metabolism_Homo sapiens_hsa002300.52442873
85Hematopoietic cell lineage_Homo sapiens_hsa046400.52038428
86Metabolic pathways_Homo sapiens_hsa011000.51958684
87Fatty acid degradation_Homo sapiens_hsa000710.49749073
88Fat digestion and absorption_Homo sapiens_hsa049750.49595363
89Fatty acid biosynthesis_Homo sapiens_hsa000610.48875940
90Circadian rhythm_Homo sapiens_hsa047100.48610250
91Fatty acid elongation_Homo sapiens_hsa000620.46379865
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43982397
93Glutamatergic synapse_Homo sapiens_hsa047240.40230321
94Dopaminergic synapse_Homo sapiens_hsa047280.39436434
95Ovarian steroidogenesis_Homo sapiens_hsa049130.38508148
96Histidine metabolism_Homo sapiens_hsa003400.35730554
97TGF-beta signaling pathway_Homo sapiens_hsa043500.35538797
98Fatty acid metabolism_Homo sapiens_hsa012120.34770005
99Mineral absorption_Homo sapiens_hsa049780.33435871
100Pyrimidine metabolism_Homo sapiens_hsa002400.31043291

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