ZNF483

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)4.41803876
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12610971
3presynaptic membrane assembly (GO:0097105)3.86554707
4behavioral response to nicotine (GO:0035095)3.81257105
5L-fucose catabolic process (GO:0042355)3.80305831
6fucose catabolic process (GO:0019317)3.80305831
7L-fucose metabolic process (GO:0042354)3.80305831
8startle response (GO:0001964)3.65203020
9response to pheromone (GO:0019236)3.62019012
10presynaptic membrane organization (GO:0097090)3.42863641
11water-soluble vitamin biosynthetic process (GO:0042364)3.42390573
12retinal cone cell development (GO:0046549)3.41912253
13protein K11-linked deubiquitination (GO:0035871)3.24876576
14serotonin metabolic process (GO:0042428)3.23951813
15atrial cardiac muscle cell action potential (GO:0086014)3.23822019
16gamma-aminobutyric acid transport (GO:0015812)3.23512775
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07136052
18G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04209927
19regulation of posttranscriptional gene silencing (GO:0060147)3.02069725
20regulation of gene silencing by miRNA (GO:0060964)3.02069725
21regulation of gene silencing by RNA (GO:0060966)3.02069725
22primary amino compound metabolic process (GO:1901160)3.01440112
23membrane depolarization during action potential (GO:0086010)3.01233185
24gamma-aminobutyric acid signaling pathway (GO:0007214)2.97505931
25negative regulation of translation, ncRNA-mediated (GO:0040033)2.96542980
26regulation of translation, ncRNA-mediated (GO:0045974)2.96542980
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96542980
28neuronal action potential propagation (GO:0019227)2.92794708
29protein polyglutamylation (GO:0018095)2.92120498
30neuronal action potential (GO:0019228)2.91439164
31cellular ketone body metabolic process (GO:0046950)2.88964512
32glutamate receptor signaling pathway (GO:0007215)2.88178060
33protein import into peroxisome matrix (GO:0016558)2.88102269
34regulation of hexokinase activity (GO:1903299)2.87084998
35regulation of glucokinase activity (GO:0033131)2.87084998
36inositol phosphate catabolic process (GO:0071545)2.86556960
37kidney morphogenesis (GO:0060993)2.85982319
38detection of light stimulus involved in sensory perception (GO:0050962)2.83764308
39detection of light stimulus involved in visual perception (GO:0050908)2.83764308
40neuron-neuron synaptic transmission (GO:0007270)2.75757441
41synaptic transmission, glutamatergic (GO:0035249)2.75010958
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73505773
43axoneme assembly (GO:0035082)2.73469836
44regulation of meiosis I (GO:0060631)2.72966218
45proline transport (GO:0015824)2.72793596
46negative regulation of DNA-dependent DNA replication (GO:2000104)2.71762551
47DNA double-strand break processing (GO:0000729)2.70936407
48regulation of neurotransmitter uptake (GO:0051580)2.68434068
49ionotropic glutamate receptor signaling pathway (GO:0035235)2.67910300
50adaptation of signaling pathway (GO:0023058)2.66579476
51positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.64930066
52sulfation (GO:0051923)2.64554624
53indole-containing compound metabolic process (GO:0042430)2.64155851
54reflex (GO:0060004)2.62629663
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62080131
56protein localization to cilium (GO:0061512)2.61148886
57ketone body metabolic process (GO:1902224)2.60601294
58C4-dicarboxylate transport (GO:0015740)2.56482807
59piRNA metabolic process (GO:0034587)2.55927674
60insulin secretion (GO:0030073)2.55638006
61transmission of nerve impulse (GO:0019226)2.55509149
62DNA deamination (GO:0045006)2.55196047
63glycerophospholipid catabolic process (GO:0046475)2.54883304
64neuron cell-cell adhesion (GO:0007158)2.53904940
65epithelial cilium movement (GO:0003351)2.49881228
66phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49772634
67inositol phosphate dephosphorylation (GO:0046855)2.49772634
68relaxation of cardiac muscle (GO:0055119)2.49344596
69calcium ion import (GO:0070509)2.47617026
70indole-containing compound catabolic process (GO:0042436)2.47468352
71indolalkylamine catabolic process (GO:0046218)2.47468352
72tryptophan catabolic process (GO:0006569)2.47468352
73protein prenylation (GO:0018342)2.47320750
74prenylation (GO:0097354)2.47320750
75positive regulation of potassium ion transmembrane transport (GO:1901381)2.47100167
76action potential (GO:0001508)2.45256554
77positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.44270871
78polyol catabolic process (GO:0046174)2.43437467
79indolalkylamine metabolic process (GO:0006586)2.43388684
80positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.43071303
81photoreceptor cell maintenance (GO:0045494)2.42149391
82kynurenine metabolic process (GO:0070189)2.41618596
83establishment of protein localization to Golgi (GO:0072600)2.40303830
84behavioral response to ethanol (GO:0048149)2.39300570
85detection of calcium ion (GO:0005513)2.38263715
86cellular potassium ion transport (GO:0071804)2.37916611
87potassium ion transmembrane transport (GO:0071805)2.37916611
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37898271
89neural tube formation (GO:0001841)2.37028019
90cochlea development (GO:0090102)2.36860870
91nonmotile primary cilium assembly (GO:0035058)2.36560432
92signal peptide processing (GO:0006465)2.35881724
93behavioral defense response (GO:0002209)2.34398211
94behavioral fear response (GO:0001662)2.34398211
95positive regulation of sodium ion transmembrane transport (GO:1902307)2.33753832
96respiratory chain complex IV assembly (GO:0008535)2.33388895
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33342356
98potassium ion transport (GO:0006813)2.32757739
99regulation of telomere maintenance (GO:0032204)2.31435467
100cyclic nucleotide catabolic process (GO:0009214)2.31129280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.74097153
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.11693298
3ZNF274_21170338_ChIP-Seq_K562_Hela2.90398855
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82757406
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66933463
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65279350
7EZH2_22144423_ChIP-Seq_EOC_Human2.59955643
8TAF15_26573619_Chip-Seq_HEK293_Human2.48019247
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47716269
10VDR_22108803_ChIP-Seq_LS180_Human2.42885736
11IGF1R_20145208_ChIP-Seq_DFB_Human2.40507606
12FUS_26573619_Chip-Seq_HEK293_Human2.34192908
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.31750931
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30906933
15P300_19829295_ChIP-Seq_ESCs_Human2.30459658
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.24092706
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21683633
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17391226
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09244038
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.06530149
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05251156
22EWS_26573619_Chip-Seq_HEK293_Human2.04074254
23SMAD4_21799915_ChIP-Seq_A2780_Human1.90571956
24STAT3_23295773_ChIP-Seq_U87_Human1.77003692
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.74224061
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73672659
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69139304
28* TCF4_23295773_ChIP-Seq_U87_Human1.62391745
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61665190
30* ER_23166858_ChIP-Seq_MCF-7_Human1.59713186
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59529715
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58648157
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58068969
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.57510611
35BCAT_22108803_ChIP-Seq_LS180_Human1.54201293
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53938712
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53783329
38CBP_20019798_ChIP-Seq_JUKART_Human1.53783329
39AR_25329375_ChIP-Seq_VCAP_Human1.51637790
40REST_21632747_ChIP-Seq_MESCs_Mouse1.51069078
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50488252
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48950543
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45979977
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43969361
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40698795
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40698795
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38280919
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38071561
49IRF1_19129219_ChIP-ChIP_H3396_Human1.37880922
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36820642
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.35037252
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33381149
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33208612
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32141143
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30081257
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.30032055
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.29664790
58TCF4_22108803_ChIP-Seq_LS180_Human1.29350191
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28751649
60RUNX2_22187159_ChIP-Seq_PCA_Human1.27854444
61* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26082313
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.24005456
63* NANOG_19829295_ChIP-Seq_ESCs_Human1.23224440
64* SOX2_19829295_ChIP-Seq_ESCs_Human1.23224440
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22942270
66AR_21572438_ChIP-Seq_LNCaP_Human1.22684672
67RNF2_27304074_Chip-Seq_NSC_Mouse1.22251438
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21332889
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.20856232
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.20383318
71TP53_22573176_ChIP-Seq_HFKS_Human1.19419365
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19248422
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18770570
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.17987350
75P53_22387025_ChIP-Seq_ESCs_Mouse1.17358899
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15641200
77* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14513849
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13523102
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11323454
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10850845
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.09554055
82CDX2_22108803_ChIP-Seq_LS180_Human1.09468911
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08485228
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08371735
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.07944857
86TP53_16413492_ChIP-PET_HCT116_Human1.06897388
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05060744
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04392319
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.04158354
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.03536641
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02923373
92KDM2B_26808549_Chip-Seq_REH_Human1.02429562
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.01613630
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01420453
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.00601235
96* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00454812
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.00131459
98P300_18555785_Chip-Seq_ESCs_Mouse0.98902938
99MYC_18940864_ChIP-ChIP_HL60_Human0.98814227
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98473632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.38800460
2MP0009046_muscle_twitch2.95942968
3MP0003195_calcinosis2.93251119
4MP0000569_abnormal_digit_pigmentation2.86214914
5MP0003787_abnormal_imprinting2.52757168
6MP0009745_abnormal_behavioral_response2.42723295
7MP0008057_abnormal_DNA_replication2.37811099
8MP0003880_abnormal_central_pattern2.33684273
9MP0002272_abnormal_nervous_system2.29161140
10MP0001501_abnormal_sleep_pattern2.29126841
11MP0005551_abnormal_eye_electrophysiolog2.19649463
12MP0001968_abnormal_touch/_nociception2.13132519
13MP0001984_abnormal_olfaction2.12594842
14MP0005646_abnormal_pituitary_gland2.10158709
15MP0002064_seizures2.08909915
16MP0002837_dystrophic_cardiac_calcinosis2.06828281
17MP0004270_analgesia2.05614166
18MP0001486_abnormal_startle_reflex2.01608698
19MP0006072_abnormal_retinal_apoptosis2.00329943
20MP0005645_abnormal_hypothalamus_physiol1.91436974
21MP0003635_abnormal_synaptic_transmissio1.87851541
22MP0002102_abnormal_ear_morphology1.80403125
23MP0002254_reproductive_system_inflammat1.79542844
24MP0002876_abnormal_thyroid_physiology1.74498140
25MP0004859_abnormal_synaptic_plasticity1.69006207
26MP0002572_abnormal_emotion/affect_behav1.68179497
27MP0002735_abnormal_chemical_nociception1.66896029
28MP0005253_abnormal_eye_physiology1.63682637
29MP0001485_abnormal_pinna_reflex1.62440442
30MP0004885_abnormal_endolymph1.60373292
31MP0002638_abnormal_pupillary_reflex1.59410251
32MP0002063_abnormal_learning/memory/cond1.59266160
33MP0006292_abnormal_olfactory_placode1.59067708
34MP0004147_increased_porphyrin_level1.58942892
35MP0004043_abnormal_pH_regulation1.57357891
36MP0008872_abnormal_physiological_respon1.54965667
37MP0002736_abnormal_nociception_after1.54718493
38MP0003890_abnormal_embryonic-extraembry1.53095326
39MP0005379_endocrine/exocrine_gland_phen1.52680663
40MP0002734_abnormal_mechanical_nocicepti1.52036707
41MP0000631_abnormal_neuroendocrine_gland1.50454455
42MP0002163_abnormal_gland_morphology1.43817091
43MP0000427_abnormal_hair_cycle1.38885562
44MP0002067_abnormal_sensory_capabilities1.38467735
45MP0005386_behavior/neurological_phenoty1.38129953
46MP0004924_abnormal_behavior1.38129953
47MP0002557_abnormal_social/conspecific_i1.35640054
48MP0003121_genomic_imprinting1.34345493
49MP0003122_maternal_imprinting1.33792695
50MP0009780_abnormal_chondrocyte_physiolo1.33158006
51MP0002909_abnormal_adrenal_gland1.32928975
52MP0006276_abnormal_autonomic_nervous1.30182912
53MP0004142_abnormal_muscle_tone1.25818904
54MP0001970_abnormal_pain_threshold1.24201980
55MP0004215_abnormal_myocardial_fiber1.20918590
56MP0010386_abnormal_urinary_bladder1.19598424
57MP0002733_abnormal_thermal_nociception1.18107628
58MP0004133_heterotaxia1.17902531
59MP0002160_abnormal_reproductive_system1.17556493
60MP0001188_hyperpigmentation1.17519463
61MP0005174_abnormal_tail_pigmentation1.14200358
62MP0003646_muscle_fatigue1.12383544
63MP0003633_abnormal_nervous_system1.12234068
64MP0003136_yellow_coat_color1.12078225
65MP0003718_maternal_effect1.08676133
66MP0002229_neurodegeneration1.07354957
67MP0004742_abnormal_vestibular_system1.06838986
68MP0005423_abnormal_somatic_nervous1.06601945
69MP0001986_abnormal_taste_sensitivity1.06163023
70MP0008058_abnormal_DNA_repair1.06011971
71MP0000778_abnormal_nervous_system1.03697518
72MP0002184_abnormal_innervation1.03010522
73MP0001502_abnormal_circadian_rhythm1.02195040
74MP0002938_white_spotting0.99028240
75MP0002090_abnormal_vision0.95856292
76MP0003879_abnormal_hair_cell0.94636568
77MP0002693_abnormal_pancreas_physiology0.93998582
78MP0001529_abnormal_vocalization0.92732904
79MP0005389_reproductive_system_phenotype0.90041851
80MP0001944_abnormal_pancreas_morphology0.89174441
81MP0001440_abnormal_grooming_behavior0.87596412
82MP0003119_abnormal_digestive_system0.86074780
83MP0004085_abnormal_heartbeat0.85406971
84MP0001963_abnormal_hearing_physiology0.82487537
85MP0000383_abnormal_hair_follicle0.82268111
86MP0002882_abnormal_neuron_morphology0.82144462
87MP0005187_abnormal_penis_morphology0.81946698
88MP0003011_delayed_dark_adaptation0.81278519
89MP0003283_abnormal_digestive_organ0.80860080
90MP0003698_abnormal_male_reproductive0.80040175
91MP0002751_abnormal_autonomic_nervous0.79591445
92MP0000955_abnormal_spinal_cord0.79117089
93MP0002752_abnormal_somatic_nervous0.78783249
94MP0001929_abnormal_gametogenesis0.77752981
95MP0003137_abnormal_impulse_conducting0.76655630
96MP0005195_abnormal_posterior_eye0.76500552
97MP0003631_nervous_system_phenotype0.74034362
98MP0002928_abnormal_bile_duct0.73535140
99MP0002066_abnormal_motor_capabilities/c0.73356767
100MP0000516_abnormal_urinary_system0.72569943

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.61069475
2Gaze-evoked nystagmus (HP:0000640)3.49425256
3Febrile seizures (HP:0002373)3.48205647
4Focal motor seizures (HP:0011153)3.48203693
5Pancreatic fibrosis (HP:0100732)3.44395470
6Hyperventilation (HP:0002883)3.43142465
7Progressive cerebellar ataxia (HP:0002073)3.08622841
8True hermaphroditism (HP:0010459)3.03319364
9Molar tooth sign on MRI (HP:0002419)3.00810286
10Abnormality of midbrain morphology (HP:0002418)3.00810286
11Nephronophthisis (HP:0000090)2.98793924
12Atonic seizures (HP:0010819)2.94701581
13Broad-based gait (HP:0002136)2.84480334
14Focal seizures (HP:0007359)2.81192397
15Abnormality of the labia minora (HP:0012880)2.80401508
16Congenital stationary night blindness (HP:0007642)2.77074176
17Hemiparesis (HP:0001269)2.74866524
18Abnormality of the renal cortex (HP:0011035)2.71671096
19Dialeptic seizures (HP:0011146)2.70538899
20Hyperinsulinemic hypoglycemia (HP:0000825)2.65920402
21Chronic hepatic failure (HP:0100626)2.65872687
22Progressive inability to walk (HP:0002505)2.59052497
23Epileptic encephalopathy (HP:0200134)2.58231889
24Protruding tongue (HP:0010808)2.57233845
25Abnormality of the renal medulla (HP:0100957)2.57203627
26Methylmalonic acidemia (HP:0002912)2.56130462
27Medial flaring of the eyebrow (HP:0010747)2.55715611
28Ketoacidosis (HP:0001993)2.54841525
29Genetic anticipation (HP:0003743)2.54356683
30Inability to walk (HP:0002540)2.48770189
31Abnormal drinking behavior (HP:0030082)2.48185911
32Polydipsia (HP:0001959)2.48185911
33Hypomagnesemia (HP:0002917)2.42225657
34Type II lissencephaly (HP:0007260)2.39018839
35Abolished electroretinogram (ERG) (HP:0000550)2.38126047
36Hypoglycemic seizures (HP:0002173)2.37749830
37Abnormality of vitamin B metabolism (HP:0004340)2.37746926
38Epileptiform EEG discharges (HP:0011182)2.37555779
39Large for gestational age (HP:0001520)2.33678482
40Intestinal atresia (HP:0011100)2.31860514
41Fair hair (HP:0002286)2.25921080
42Neoplasm of the adrenal cortex (HP:0100641)2.25293859
43Attenuation of retinal blood vessels (HP:0007843)2.25120544
44Absence seizures (HP:0002121)2.23962464
45Homocystinuria (HP:0002156)2.19835600
46Abnormality of homocysteine metabolism (HP:0010919)2.19835600
47Colon cancer (HP:0003003)2.17613659
48Hypothermia (HP:0002045)2.16269551
49Pendular nystagmus (HP:0012043)2.15373221
50EEG with generalized epileptiform discharges (HP:0011198)2.15237676
51Cystic liver disease (HP:0006706)2.13539774
52Renal cortical cysts (HP:0000803)2.12321974
53Hypoglycemic coma (HP:0001325)2.09406495
54Hypsarrhythmia (HP:0002521)2.08406061
55Abnormality of the vitamin B12 metabolism (HP:0004341)2.08198563
56Drooling (HP:0002307)2.07756896
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.05968303
58Gait imbalance (HP:0002141)2.05172909
59Methylmalonic aciduria (HP:0012120)2.04242605
60Genital tract atresia (HP:0001827)2.04207814
61Optic nerve hypoplasia (HP:0000609)2.03775673
62Generalized tonic-clonic seizures (HP:0002069)2.00541149
63Tubular atrophy (HP:0000092)1.99289509
64Congenital primary aphakia (HP:0007707)1.97359364
65Ketosis (HP:0001946)1.95268451
66Furrowed tongue (HP:0000221)1.94478560
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92133201
68Abnormality of alanine metabolism (HP:0010916)1.90421142
69Hyperalaninemia (HP:0003348)1.90421142
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90421142
71Vaginal atresia (HP:0000148)1.89852534
72Poor coordination (HP:0002370)1.89797459
73Polyuria (HP:0000103)1.86933606
74Lissencephaly (HP:0001339)1.85929992
75Widely spaced teeth (HP:0000687)1.83515526
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.83135759
77Excessive salivation (HP:0003781)1.82461959
78Hypoplasia of the pons (HP:0012110)1.81149150
79Decreased circulating renin level (HP:0003351)1.80814739
80Generalized hypopigmentation of hair (HP:0011358)1.80803444
81Nephrogenic diabetes insipidus (HP:0009806)1.80801506
82Absent speech (HP:0001344)1.80546646
83Abnormality of the pons (HP:0007361)1.80022772
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79001213
85Stomach cancer (HP:0012126)1.78834288
86Aqueductal stenosis (HP:0002410)1.78067218
87Increased circulating renin level (HP:0000848)1.77757533
88Abnormality of the pancreatic islet cells (HP:0006476)1.75951198
89Abnormality of endocrine pancreas physiology (HP:0012093)1.75951198
90Agitation (HP:0000713)1.74269375
91Sclerocornea (HP:0000647)1.70924181
92Decreased central vision (HP:0007663)1.68844731
93Hyperglycemia (HP:0003074)1.67837223
94Congenital hepatic fibrosis (HP:0002612)1.66389822
95Abnormal biliary tract physiology (HP:0012439)1.63958580
96Bile duct proliferation (HP:0001408)1.63958580
97Clumsiness (HP:0002312)1.62716917
98Thyroiditis (HP:0100646)1.60838836
99Bony spicule pigmentary retinopathy (HP:0007737)1.60514524
100Abnormality of vitamin metabolism (HP:0100508)1.60356504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.40930329
2CASK3.12282190
3BMPR1B2.58018912
4WNK32.51394257
5ZAK2.46536779
6TNIK2.27345449
7ADRBK22.23463402
8ACVR1B2.19946101
9MAP4K22.07035990
10NTRK32.05534672
11MAP3K41.97378388
12GRK11.96133716
13FGFR21.94727359
14NUAK11.88684087
15MKNK21.85430638
16PINK11.80589013
17OXSR11.65308842
18AKT31.53618788
19STK38L1.53216531
20STK391.45262736
21MAPK131.43864975
22WNK41.38368084
23DAPK21.37512053
24INSRR1.32565363
25MARK11.30984460
26PLK21.27970237
27CAMKK21.24660235
28TRIM281.22498339
29PAK31.20383289
30PNCK1.19367469
31PRKCG1.16729979
32NTRK21.16511179
33BRSK21.16258736
34NLK1.08349749
35TLK11.03012823
36PRKCE1.02052617
37PLK30.99247912
38TSSK60.96311839
39CSNK1G10.95068703
40TAF10.94587181
41CSNK1G20.93991687
42TAOK30.91514511
43MST40.89522669
44SGK20.88641586
45EPHA40.87476236
46MAP2K70.83871336
47TIE10.81588934
48STK30.78753354
49MKNK10.77986280
50CAMK1G0.77538615
51EIF2AK30.76542713
52CSNK1A1L0.76056621
53CAMK2A0.74222648
54PHKG10.73417469
55PHKG20.73417469
56FER0.71657104
57VRK10.69527445
58STK110.68519224
59ADRBK10.68213779
60ERBB30.67704104
61CAMK10.66171994
62CSNK1G30.65743339
63SGK2230.63046196
64SGK4940.63046196
65PASK0.59626707
66TXK0.59606685
67SGK10.59033730
68CAMK1D0.58893966
69DYRK20.56664702
70DAPK10.50800302
71CSNK1A10.50795071
72CAMK2B0.50577974
73TEC0.50150729
74PLK40.48720823
75CSNK1D0.48297435
76PTK2B0.47102597
77CDK50.46268715
78MUSK0.45014701
79PLK10.44700649
80PIK3CA0.44127281
81ATM0.44073692
82MAP3K90.44029581
83TGFBR10.43878594
84CAMKK10.41548120
85DYRK1A0.41003995
86BRD40.40003251
87PRKACA0.39118624
88WNK10.39065688
89PRKG10.39029848
90CAMK40.38970911
91BCR0.38314102
92RPS6KA50.38286505
93CDK30.36937513
94CDC70.36848142
95CAMK2D0.36682952
96PRKCZ0.36551188
97CSNK1E0.35922410
98IRAK10.35766614
99PRKACB0.35331671
100PKN10.35058455

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76917903
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.01270514
3Selenocompound metabolism_Homo sapiens_hsa004502.61140842
4Phototransduction_Homo sapiens_hsa047442.46312580
5Insulin secretion_Homo sapiens_hsa049112.38592886
6Butanoate metabolism_Homo sapiens_hsa006502.22954450
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15065751
8Taste transduction_Homo sapiens_hsa047421.96741103
9Morphine addiction_Homo sapiens_hsa050321.95786517
10GABAergic synapse_Homo sapiens_hsa047271.95350320
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91119333
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86953047
13Protein export_Homo sapiens_hsa030601.86845432
14Circadian entrainment_Homo sapiens_hsa047131.83353303
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77312193
16Glutamatergic synapse_Homo sapiens_hsa047241.73051537
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71638584
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62053417
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58977920
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58623900
21One carbon pool by folate_Homo sapiens_hsa006701.49486611
22Ether lipid metabolism_Homo sapiens_hsa005651.47538396
23Propanoate metabolism_Homo sapiens_hsa006401.43941870
24Circadian rhythm_Homo sapiens_hsa047101.42496166
25Amphetamine addiction_Homo sapiens_hsa050311.41728398
26Nitrogen metabolism_Homo sapiens_hsa009101.40790782
27Linoleic acid metabolism_Homo sapiens_hsa005911.36707983
28Tryptophan metabolism_Homo sapiens_hsa003801.34952268
29Salivary secretion_Homo sapiens_hsa049701.34743870
30Homologous recombination_Homo sapiens_hsa034401.33805601
31Basal transcription factors_Homo sapiens_hsa030221.33229473
32Fanconi anemia pathway_Homo sapiens_hsa034601.30882900
33Olfactory transduction_Homo sapiens_hsa047401.28454346
34Caffeine metabolism_Homo sapiens_hsa002321.26500174
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23439600
36Serotonergic synapse_Homo sapiens_hsa047261.23325406
37Non-homologous end-joining_Homo sapiens_hsa034501.22570324
38RNA degradation_Homo sapiens_hsa030181.21423918
39Dopaminergic synapse_Homo sapiens_hsa047281.17494390
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16607781
41Regulation of autophagy_Homo sapiens_hsa041401.12639919
42RNA polymerase_Homo sapiens_hsa030201.09108946
43Renin secretion_Homo sapiens_hsa049241.04588664
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04072170
45Cocaine addiction_Homo sapiens_hsa050301.00313891
46Peroxisome_Homo sapiens_hsa041460.98911819
47Synaptic vesicle cycle_Homo sapiens_hsa047210.98659930
48Vitamin B6 metabolism_Homo sapiens_hsa007500.98177132
49Calcium signaling pathway_Homo sapiens_hsa040200.95885711
50Dorso-ventral axis formation_Homo sapiens_hsa043200.94284473
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92670675
52Mineral absorption_Homo sapiens_hsa049780.91515233
53ABC transporters_Homo sapiens_hsa020100.91331967
54beta-Alanine metabolism_Homo sapiens_hsa004100.91322529
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.91155405
56Oxidative phosphorylation_Homo sapiens_hsa001900.88595626
57Cardiac muscle contraction_Homo sapiens_hsa042600.87401863
58Long-term depression_Homo sapiens_hsa047300.85446814
59Type II diabetes mellitus_Homo sapiens_hsa049300.85152016
60cAMP signaling pathway_Homo sapiens_hsa040240.83948098
61Gastric acid secretion_Homo sapiens_hsa049710.83672942
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81321992
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.79738795
64Collecting duct acid secretion_Homo sapiens_hsa049660.79339388
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79318222
66Ovarian steroidogenesis_Homo sapiens_hsa049130.76300645
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75253198
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73248808
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72212133
70Long-term potentiation_Homo sapiens_hsa047200.71195880
71Pancreatic secretion_Homo sapiens_hsa049720.70553043
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68856718
73Oocyte meiosis_Homo sapiens_hsa041140.68652051
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66844947
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65233684
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64445392
77Cholinergic synapse_Homo sapiens_hsa047250.63566266
78Thyroid hormone synthesis_Homo sapiens_hsa049180.61498823
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.59778019
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.58925800
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58049589
82Retinol metabolism_Homo sapiens_hsa008300.57693572
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56973524
84Purine metabolism_Homo sapiens_hsa002300.55823986
85Oxytocin signaling pathway_Homo sapiens_hsa049210.54914505
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50968532
87Chemical carcinogenesis_Homo sapiens_hsa052040.47218281
88Alzheimers disease_Homo sapiens_hsa050100.46915274
89Parkinsons disease_Homo sapiens_hsa050120.46395709
90Alcoholism_Homo sapiens_hsa050340.45997835
91Histidine metabolism_Homo sapiens_hsa003400.44015970
92Glycerolipid metabolism_Homo sapiens_hsa005610.42773998
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42594855
94Hedgehog signaling pathway_Homo sapiens_hsa043400.41417990
95Arachidonic acid metabolism_Homo sapiens_hsa005900.40914709
96Bile secretion_Homo sapiens_hsa049760.39642881
97Huntingtons disease_Homo sapiens_hsa050160.38430682
98Lysine degradation_Homo sapiens_hsa003100.36481235
99Sulfur metabolism_Homo sapiens_hsa009200.36219878
100Fatty acid elongation_Homo sapiens_hsa000620.35299993

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