ZNF480

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.38718139
2indolalkylamine metabolic process (GO:0006586)4.19927451
3monoubiquitinated protein deubiquitination (GO:0035520)4.14761783
4kynurenine metabolic process (GO:0070189)4.09600929
5tryptophan catabolic process (GO:0006569)4.02795929
6indole-containing compound catabolic process (GO:0042436)4.02795929
7indolalkylamine catabolic process (GO:0046218)4.02795929
8replication fork processing (GO:0031297)3.98157085
9regulation of sarcomere organization (GO:0060297)3.97446907
10protein K11-linked deubiquitination (GO:0035871)3.96809841
11DNA double-strand break processing (GO:0000729)3.90072971
12tryptophan metabolic process (GO:0006568)3.71492081
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.61593176
14signal peptide processing (GO:0006465)3.61504783
15tachykinin receptor signaling pathway (GO:0007217)3.43164055
16protein K48-linked deubiquitination (GO:0071108)3.43103651
17regulation of hippo signaling (GO:0035330)3.33622628
18behavioral response to nicotine (GO:0035095)3.32973092
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.32453643
20photoreceptor cell maintenance (GO:0045494)3.31359788
21detection of light stimulus involved in sensory perception (GO:0050962)3.21454054
22detection of light stimulus involved in visual perception (GO:0050908)3.21454054
23recombinational repair (GO:0000725)3.20973856
24double-strand break repair via homologous recombination (GO:0000724)3.20079872
25prenylation (GO:0097354)3.14534451
26protein prenylation (GO:0018342)3.14534451
27positive regulation of oligodendrocyte differentiation (GO:0048714)3.12442845
28positive regulation of developmental pigmentation (GO:0048087)3.12377588
29fucose catabolic process (GO:0019317)3.08804057
30L-fucose metabolic process (GO:0042354)3.08804057
31L-fucose catabolic process (GO:0042355)3.08804057
32establishment of protein localization to Golgi (GO:0072600)3.06952277
33retinal cone cell development (GO:0046549)3.04409244
34maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00694278
35rRNA catabolic process (GO:0016075)3.00062667
36cilium or flagellum-dependent cell motility (GO:0001539)2.99716692
37negative regulation of transcription regulatory region DNA binding (GO:2000678)2.98677321
38protein localization to cilium (GO:0061512)2.98401782
39regulation of gene silencing by RNA (GO:0060966)2.94498217
40regulation of posttranscriptional gene silencing (GO:0060147)2.94498217
41regulation of gene silencing by miRNA (GO:0060964)2.94498217
42resolution of meiotic recombination intermediates (GO:0000712)2.93911819
43DNA deamination (GO:0045006)2.92118735
44behavioral response to ethanol (GO:0048149)2.92039032
45indole-containing compound metabolic process (GO:0042430)2.90130710
46protein polyglutamylation (GO:0018095)2.89426329
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86886285
48axoneme assembly (GO:0035082)2.85066061
49reflex (GO:0060004)2.84489676
50interkinetic nuclear migration (GO:0022027)2.83149353
51microtubule anchoring (GO:0034453)2.80844827
52protein K63-linked deubiquitination (GO:0070536)2.78367840
53negative regulation of translation, ncRNA-mediated (GO:0040033)2.78165433
54regulation of translation, ncRNA-mediated (GO:0045974)2.78165433
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78165433
56regulation of establishment of cell polarity (GO:2000114)2.77751117
57regulation of protein glycosylation (GO:0060049)2.76905527
58preassembly of GPI anchor in ER membrane (GO:0016254)2.76463631
59microtubule depolymerization (GO:0007019)2.75024926
60cornea development in camera-type eye (GO:0061303)2.71299250
61cilium organization (GO:0044782)2.71234523
62microtubule polymerization or depolymerization (GO:0031109)2.70574973
63reciprocal DNA recombination (GO:0035825)2.70498751
64reciprocal meiotic recombination (GO:0007131)2.70498751
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69693119
66regulation of mitotic spindle checkpoint (GO:1903504)2.69693119
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.69632310
68ncRNA catabolic process (GO:0034661)2.69152342
69regulation of telomere maintenance (GO:0032204)2.69043150
70benzene-containing compound metabolic process (GO:0042537)2.68269750
71mannosylation (GO:0097502)2.67951772
72intraciliary transport (GO:0042073)2.64815902
73regulation of pigment cell differentiation (GO:0050932)2.64556475
74DNA integration (GO:0015074)2.64035146
75cilium assembly (GO:0042384)2.63024946
76cellular ketone body metabolic process (GO:0046950)2.62318471
77regulation of centriole replication (GO:0046599)2.61689444
78respiratory chain complex IV assembly (GO:0008535)2.59194601
79centriole replication (GO:0007099)2.58180717
80cilium morphogenesis (GO:0060271)2.58049024
81seminiferous tubule development (GO:0072520)2.57022618
82protein complex biogenesis (GO:0070271)2.56741149
83anterograde synaptic vesicle transport (GO:0048490)2.55656460
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53618860
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53618860
86isotype switching (GO:0045190)2.53618860
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.53004410
88NADH dehydrogenase complex assembly (GO:0010257)2.53004410
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53004410
90cellular response to sterol (GO:0036315)2.52352754
91peptidyl-histidine modification (GO:0018202)2.50875523
92DNA methylation involved in gamete generation (GO:0043046)2.49200685
93response to pheromone (GO:0019236)2.49001645
94mitochondrial respiratory chain complex assembly (GO:0033108)2.48016418
95histone H3-K9 methylation (GO:0051567)2.47602605
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47390164
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.47390164
98acrosome assembly (GO:0001675)2.46807869
99negative regulation of mast cell activation (GO:0033004)2.46399806
100embryonic epithelial tube formation (GO:0001838)2.44644191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.51342376
2GBX2_23144817_ChIP-Seq_PC3_Human3.21707267
3IGF1R_20145208_ChIP-Seq_DFB_Human3.07065501
4VDR_22108803_ChIP-Seq_LS180_Human2.97334778
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89536507
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87883238
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70942117
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.67679635
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64682865
10TAF15_26573619_Chip-Seq_HEK293_Human2.53392208
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.52914340
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42388439
13EWS_26573619_Chip-Seq_HEK293_Human2.39169292
14FUS_26573619_Chip-Seq_HEK293_Human2.36855056
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28698794
16P300_19829295_ChIP-Seq_ESCs_Human2.25243822
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08208279
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08080954
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03006800
20ER_23166858_ChIP-Seq_MCF-7_Human1.92526753
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87999496
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87653806
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87520789
24STAT3_23295773_ChIP-Seq_U87_Human1.73304647
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.69416282
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.68034662
27SMAD4_21799915_ChIP-Seq_A2780_Human1.67923664
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67712321
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66674562
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65525660
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63556607
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62590011
33IRF1_19129219_ChIP-ChIP_H3396_Human1.61051767
34CBP_20019798_ChIP-Seq_JUKART_Human1.60086684
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60086684
36BCAT_22108803_ChIP-Seq_LS180_Human1.57773703
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56379375
38TCF4_23295773_ChIP-Seq_U87_Human1.54691272
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.51782534
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.51612009
41ELK1_19687146_ChIP-ChIP_HELA_Human1.50265750
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48652598
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48410504
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45298044
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44828129
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44828129
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44751621
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43660908
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.43513409
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42120163
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40998672
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40826536
53AR_25329375_ChIP-Seq_VCAP_Human1.38724703
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38435741
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.37967649
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37519779
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36619346
58EZH2_22144423_ChIP-Seq_EOC_Human1.36024422
59TCF4_22108803_ChIP-Seq_LS180_Human1.33471231
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.33242229
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.32633894
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31052737
63TP53_22573176_ChIP-Seq_HFKS_Human1.30847856
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30297450
65* NANOG_19829295_ChIP-Seq_ESCs_Human1.28400420
66* SOX2_19829295_ChIP-Seq_ESCs_Human1.28400420
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.26586150
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26513133
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25755107
70AR_21572438_ChIP-Seq_LNCaP_Human1.25043891
71RUNX2_22187159_ChIP-Seq_PCA_Human1.24853794
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22755918
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20141607
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.19247029
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18528278
76* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18451000
77P53_22387025_ChIP-Seq_ESCs_Mouse1.17930353
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17094712
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16305193
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15883611
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.15344966
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13512092
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12567428
84CDX2_22108803_ChIP-Seq_LS180_Human1.11900909
85* EST1_17652178_ChIP-ChIP_JURKAT_Human1.11655298
86MYC_18940864_ChIP-ChIP_HL60_Human1.11384087
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09897368
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.08731561
89P300_18555785_Chip-Seq_ESCs_Mouse1.08626514
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.08136059
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06983463
92VDR_23849224_ChIP-Seq_CD4+_Human1.04811696
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04163593
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04011540
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.03984503
96RNF2_27304074_Chip-Seq_NSC_Mouse1.03156011
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00491692
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99146619
99OCT4_18555785_Chip-Seq_ESCs_Mouse0.99090438
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98976588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.94159932
2MP0008057_abnormal_DNA_replication3.60399835
3MP0008877_abnormal_DNA_methylation3.17233974
4MP0003646_muscle_fatigue2.61904936
5MP0003787_abnormal_imprinting2.50861011
6MP0002102_abnormal_ear_morphology2.47757901
7MP0005551_abnormal_eye_electrophysiolog2.41251781
8MP0003890_abnormal_embryonic-extraembry2.24878988
9MP0008058_abnormal_DNA_repair2.23198307
10MP0010094_abnormal_chromosome_stability2.07586417
11MP0003195_calcinosis1.97807483
12MP0005253_abnormal_eye_physiology1.97243044
13MP0000372_irregular_coat_pigmentation1.97154707
14MP0002736_abnormal_nociception_after1.96385498
15MP0005075_abnormal_melanosome_morpholog1.93819746
16MP0006072_abnormal_retinal_apoptosis1.89104584
17MP0006292_abnormal_olfactory_placode1.86606792
18MP0009046_muscle_twitch1.86465674
19MP0000427_abnormal_hair_cycle1.73258735
20MP0001968_abnormal_touch/_nociception1.70223174
21MP0004043_abnormal_pH_regulation1.69514811
22MP0002234_abnormal_pharynx_morphology1.68380276
23MP0008872_abnormal_physiological_respon1.67409188
24MP0002837_dystrophic_cardiac_calcinosis1.66652779
25MP0006276_abnormal_autonomic_nervous1.61894713
26MP0003718_maternal_effect1.60988222
27MP0002938_white_spotting1.54337218
28MP0001501_abnormal_sleep_pattern1.52472346
29MP0004142_abnormal_muscle_tone1.50530543
30MP0003567_abnormal_fetal_cardiomyocyte1.46513280
31MP0003121_genomic_imprinting1.42334636
32MP0004215_abnormal_myocardial_fiber1.38964481
33MP0003937_abnormal_limbs/digits/tail_de1.35931355
34MP0001529_abnormal_vocalization1.32549126
35MP0001485_abnormal_pinna_reflex1.31295567
36MP0009697_abnormal_copulation1.29418460
37MP0000631_abnormal_neuroendocrine_gland1.29345370
38MP0010386_abnormal_urinary_bladder1.28525071
39MP0004133_heterotaxia1.28078957
40MP0005174_abnormal_tail_pigmentation1.26990053
41MP0004147_increased_porphyrin_level1.25926033
42MP0003786_premature_aging1.24890779
43MP0003880_abnormal_central_pattern1.24458710
44MP0003136_yellow_coat_color1.21250637
45MP0004145_abnormal_muscle_electrophysio1.20920822
46MP0005646_abnormal_pituitary_gland1.20699521
47MP0005645_abnormal_hypothalamus_physiol1.19733814
48MP0006035_abnormal_mitochondrial_morpho1.17705018
49MP0001293_anophthalmia1.13273505
50MP0002638_abnormal_pupillary_reflex1.12114008
51MP0002751_abnormal_autonomic_nervous1.10217480
52MP0002095_abnormal_skin_pigmentation1.08708596
53MP0004924_abnormal_behavior1.06147474
54MP0005386_behavior/neurological_phenoty1.06147474
55MP0001486_abnormal_startle_reflex1.05055591
56MP0005367_renal/urinary_system_phenotyp1.04816536
57MP0000516_abnormal_urinary_system1.04816536
58MP0009745_abnormal_behavioral_response1.04119106
59MP0002876_abnormal_thyroid_physiology1.02304063
60MP0005195_abnormal_posterior_eye1.02073201
61MP0002272_abnormal_nervous_system0.99830828
62MP0001984_abnormal_olfaction0.99618950
63MP0000383_abnormal_hair_follicle0.99259298
64MP0008789_abnormal_olfactory_epithelium0.99131442
65MP0002254_reproductive_system_inflammat0.98440457
66MP0008995_early_reproductive_senescence0.97837106
67MP0005391_vision/eye_phenotype0.97672853
68MP0003119_abnormal_digestive_system0.96656999
69MP0002160_abnormal_reproductive_system0.95760665
70MP0000371_diluted_coat_color0.95568115
71MP0001324_abnormal_eye_pigmentation0.95384818
72MP0000778_abnormal_nervous_system0.95184058
73MP0005266_abnormal_metabolism0.94362796
74MP0003698_abnormal_male_reproductive0.92488305
75MP0005395_other_phenotype0.92221245
76MP0005389_reproductive_system_phenotype0.91993558
77MP0001986_abnormal_taste_sensitivity0.90646152
78MP0001929_abnormal_gametogenesis0.86844372
79MP0002735_abnormal_chemical_nociception0.84855994
80MP0002752_abnormal_somatic_nervous0.84824417
81MP0005410_abnormal_fertilization0.83861272
82MP0000653_abnormal_sex_gland0.83709065
83MP0002067_abnormal_sensory_capabilities0.83579725
84MP0000538_abnormal_urinary_bladder0.83293984
85MP0001764_abnormal_homeostasis0.83138697
86MP0001919_abnormal_reproductive_system0.82602555
87MP0002210_abnormal_sex_determination0.82258466
88MP0002557_abnormal_social/conspecific_i0.80253180
89MP0001145_abnormal_male_reproductive0.79806256
90MP0002090_abnormal_vision0.79778801
91MP0003137_abnormal_impulse_conducting0.79334485
92MP0004085_abnormal_heartbeat0.78267930
93MP0000647_abnormal_sebaceous_gland0.77398828
94MP0005085_abnormal_gallbladder_physiolo0.76922390
95MP0000230_abnormal_systemic_arterial0.73628669
96MP0002184_abnormal_innervation0.73626570
97MP0006054_spinal_hemorrhage0.72501458
98MP0002233_abnormal_nose_morphology0.71210608
99MP0002229_neurodegeneration0.70534984
100MP0008775_abnormal_heart_ventricle0.70310810

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.11100001
2Pancreatic fibrosis (HP:0100732)3.77582636
3True hermaphroditism (HP:0010459)3.70035349
4Abnormality of midbrain morphology (HP:0002418)3.39721809
5Molar tooth sign on MRI (HP:0002419)3.39721809
6Nephronophthisis (HP:0000090)3.28052740
7Chronic hepatic failure (HP:0100626)3.27612111
8Attenuation of retinal blood vessels (HP:0007843)3.18776456
9Abnormality of the renal cortex (HP:0011035)3.08635219
10Medial flaring of the eyebrow (HP:0010747)3.04474146
11Congenital stationary night blindness (HP:0007642)3.03610750
12Hyperventilation (HP:0002883)2.98971733
13Renal cortical cysts (HP:0000803)2.96229939
14Abnormality of the renal medulla (HP:0100957)2.92533220
15Genetic anticipation (HP:0003743)2.84359802
16Volvulus (HP:0002580)2.81932549
17Protruding tongue (HP:0010808)2.71442863
18Gaze-evoked nystagmus (HP:0000640)2.68019588
19Abolished electroretinogram (ERG) (HP:0000550)2.64445498
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.61358846
21Nephrogenic diabetes insipidus (HP:0009806)2.60268398
22Intestinal atresia (HP:0011100)2.56279394
23Congenital primary aphakia (HP:0007707)2.54529361
24Colon cancer (HP:0003003)2.53375488
25Chromsome breakage (HP:0040012)2.48684481
26Gait imbalance (HP:0002141)2.48037241
27Abnormality of chromosome stability (HP:0003220)2.47767114
28Genital tract atresia (HP:0001827)2.45655634
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.40379383
30Progressive inability to walk (HP:0002505)2.37973636
31Sclerocornea (HP:0000647)2.37878263
32Vaginal atresia (HP:0000148)2.32555152
33Cystic liver disease (HP:0006706)2.31243810
34Thyroiditis (HP:0100646)2.31079922
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.30719350
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25896731
37Anencephaly (HP:0002323)2.25478364
38Postaxial foot polydactyly (HP:0001830)2.22641291
39Bony spicule pigmentary retinopathy (HP:0007737)2.20847882
40Tubulointerstitial nephritis (HP:0001970)2.18066798
41Abnormality of the labia minora (HP:0012880)2.17118374
42Abnormality of alanine metabolism (HP:0010916)2.16103986
43Hyperalaninemia (HP:0003348)2.16103986
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16103986
45Oligodactyly (hands) (HP:0001180)2.11646565
46Type II lissencephaly (HP:0007260)2.11047329
47Lissencephaly (HP:0001339)2.09311194
48Central scotoma (HP:0000603)2.07749286
49Sloping forehead (HP:0000340)2.07117802
50Neoplasm of the adrenal cortex (HP:0100641)2.06080194
51Inability to walk (HP:0002540)2.04726002
52Abnormality of the ileum (HP:0001549)2.04578655
53Progressive cerebellar ataxia (HP:0002073)2.03886833
54Increased CSF lactate (HP:0002490)2.02544981
55Poor coordination (HP:0002370)1.99385010
56Abnormality of B cell number (HP:0010975)1.99201546
57Small hand (HP:0200055)1.98040139
58Cerebellar dysplasia (HP:0007033)1.96994038
59Congenital hepatic fibrosis (HP:0002612)1.96192338
60Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95177856
61Male pseudohermaphroditism (HP:0000037)1.94933370
62Meckel diverticulum (HP:0002245)1.94563491
63Fair hair (HP:0002286)1.92011860
64Absent speech (HP:0001344)1.87412399
65Facial diplegia (HP:0001349)1.85779854
66Astigmatism (HP:0000483)1.85412668
67Broad-based gait (HP:0002136)1.84807478
68Acute necrotizing encephalopathy (HP:0006965)1.84688233
69Abnormality of macular pigmentation (HP:0008002)1.83787724
70Increased corneal curvature (HP:0100692)1.81231048
71Keratoconus (HP:0000563)1.81231048
72Methylmalonic acidemia (HP:0002912)1.80596335
73Methylmalonic aciduria (HP:0012120)1.79583653
74Tubular atrophy (HP:0000092)1.78065519
75Preaxial hand polydactyly (HP:0001177)1.77597224
76Chorioretinal atrophy (HP:0000533)1.77225489
77Patellar aplasia (HP:0006443)1.76937269
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.76338051
79Hypoplasia of the pons (HP:0012110)1.76305196
80Constricted visual fields (HP:0001133)1.75812305
81Abnormality of the pons (HP:0007361)1.74932266
82Furrowed tongue (HP:0000221)1.74855627
83Clubbing of toes (HP:0100760)1.74529807
84Dandy-Walker malformation (HP:0001305)1.74145458
85Acute encephalopathy (HP:0006846)1.73099920
86Hypoplastic iliac wings (HP:0002866)1.73043879
87Abnormal biliary tract physiology (HP:0012439)1.71898701
88Bile duct proliferation (HP:0001408)1.71898701
89Postaxial hand polydactyly (HP:0001162)1.71735510
90Absent forearm bone (HP:0003953)1.70214861
91Aplasia involving forearm bones (HP:0009822)1.70214861
92Abnormal rod and cone electroretinograms (HP:0008323)1.69805034
93Progressive macrocephaly (HP:0004481)1.69566804
94Clumsiness (HP:0002312)1.69286412
95Thyroid-stimulating hormone excess (HP:0002925)1.68454501
96Congenital sensorineural hearing impairment (HP:0008527)1.66773738
97B lymphocytopenia (HP:0010976)1.66308587
98Absent radius (HP:0003974)1.66127996
99Bifid tongue (HP:0010297)1.66021187
100Drooling (HP:0002307)1.65840211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.67886089
2MAP4K23.33454863
3NUAK13.11927721
4WNK33.08749232
5ACVR1B3.07525945
6BMPR1B2.61484035
7TRIM282.23633958
8MAPK132.06974964
9STK38L2.04604703
10ADRBK22.02498851
11MKNK21.92201638
12ZAK1.88890556
13TAOK31.75072696
14BCR1.65173616
15CASK1.62397962
16GRK11.57381718
17ERBB31.56874498
18INSRR1.55406859
19BRSK21.43543462
20STK391.38004374
21OXSR11.33247611
22MKNK11.22565998
23PLK41.14604080
24TEC1.10997795
25PBK1.10711465
26TXK1.07810653
27PINK11.03399466
28PAK31.02332193
29MAP3K40.98238631
30EIF2AK30.97740929
31WNK40.96400978
32CSNK1G20.93404045
33ADRBK10.92270066
34AKT30.88747015
35CDC70.86958058
36FER0.83433747
37MARK10.83195956
38TNIK0.81488903
39MST40.81314358
40CSNK1G10.79662255
41PLK30.78905914
42PRKCE0.75920557
43PDK20.74836155
44LATS10.74208006
45NLK0.73835997
46CSNK1A1L0.73562457
47PLK20.72685641
48ATR0.72385531
49STK160.71816981
50SRPK10.71789055
51TAF10.70355026
52VRK10.70258233
53OBSCN0.69589852
54STK30.69108093
55PIK3CG0.67210572
56TGFBR10.66755898
57ATM0.66753516
58WEE10.66459352
59PIK3CA0.66232273
60BCKDK0.64808446
61PLK10.64306976
62TLK10.63433442
63NTRK30.63183556
64CSNK1G30.62428467
65FGFR20.57991358
66CAMKK20.54873452
67DYRK30.54539361
68CHEK20.54379721
69EPHA40.54120988
70BRD40.50472674
71TIE10.49484813
72NEK10.49450721
73BUB10.49258447
74CAMK40.49205173
75PRKCG0.47604343
76PRKAA20.46652659
77IRAK10.43001729
78PRKCQ0.42991632
79SGK20.42179641
80CAMK2A0.42154312
81EPHA30.41470522
82MAP2K70.40526907
83DYRK1A0.39611668
84CSNK1D0.38027064
85DYRK20.37598922
86FLT30.37589769
87CSNK1A10.37416918
88RPS6KA50.37299522
89ITK0.35309118
90PRKCB0.33757013
91PRKACB0.33477370
92VRK20.33383165
93RPS6KA40.32496601
94CDK30.32467835
95MARK30.30399776
96DAPK20.29556879
97PRKACA0.29149247
98PRKAA10.29024514
99CCNB10.28806530
100PKN10.28129776

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.04125360
2Non-homologous end-joining_Homo sapiens_hsa034503.00311082
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.82135863
4Fanconi anemia pathway_Homo sapiens_hsa034602.82050663
5Phototransduction_Homo sapiens_hsa047442.48487021
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40580058
7Basal transcription factors_Homo sapiens_hsa030222.40357520
8Butanoate metabolism_Homo sapiens_hsa006502.40142446
9RNA polymerase_Homo sapiens_hsa030202.37796860
10Tryptophan metabolism_Homo sapiens_hsa003801.95153867
11Propanoate metabolism_Homo sapiens_hsa006401.87223162
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86501618
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82601565
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76857224
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76728327
16Selenocompound metabolism_Homo sapiens_hsa004501.76038546
17Nitrogen metabolism_Homo sapiens_hsa009101.73805908
18Nicotine addiction_Homo sapiens_hsa050331.71640235
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.71353418
20Linoleic acid metabolism_Homo sapiens_hsa005911.70430595
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.69915985
22Protein export_Homo sapiens_hsa030601.69256521
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68061643
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62717803
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60545117
26Nucleotide excision repair_Homo sapiens_hsa034201.53646207
27RNA degradation_Homo sapiens_hsa030181.53018296
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48992035
29ABC transporters_Homo sapiens_hsa020101.48116475
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48112681
31Ether lipid metabolism_Homo sapiens_hsa005651.38476701
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35248956
33Mismatch repair_Homo sapiens_hsa034301.32887617
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25715398
35Retinol metabolism_Homo sapiens_hsa008301.22499114
36Olfactory transduction_Homo sapiens_hsa047401.21398222
37Taste transduction_Homo sapiens_hsa047421.18934601
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15173204
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12843813
40Caffeine metabolism_Homo sapiens_hsa002321.12769831
41Chemical carcinogenesis_Homo sapiens_hsa052041.07573658
42One carbon pool by folate_Homo sapiens_hsa006701.03511280
43Lysine degradation_Homo sapiens_hsa003101.00588687
44Peroxisome_Homo sapiens_hsa041460.95404248
45beta-Alanine metabolism_Homo sapiens_hsa004100.94327021
46Purine metabolism_Homo sapiens_hsa002300.94187292
47Fatty acid degradation_Homo sapiens_hsa000710.92711800
48Morphine addiction_Homo sapiens_hsa050320.91644447
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88752181
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.87831523
51Glycerolipid metabolism_Homo sapiens_hsa005610.87371267
52RNA transport_Homo sapiens_hsa030130.85864075
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85267574
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85084255
55Histidine metabolism_Homo sapiens_hsa003400.84723497
56Serotonergic synapse_Homo sapiens_hsa047260.83681046
57Steroid biosynthesis_Homo sapiens_hsa001000.81950293
58Regulation of autophagy_Homo sapiens_hsa041400.79713644
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77413685
60GABAergic synapse_Homo sapiens_hsa047270.76298777
61Primary immunodeficiency_Homo sapiens_hsa053400.75559883
62Circadian rhythm_Homo sapiens_hsa047100.74169542
63Oxidative phosphorylation_Homo sapiens_hsa001900.73860588
64Huntingtons disease_Homo sapiens_hsa050160.71333645
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71203688
66Cell cycle_Homo sapiens_hsa041100.70366513
67Circadian entrainment_Homo sapiens_hsa047130.68866501
68Glutamatergic synapse_Homo sapiens_hsa047240.67577338
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67521786
70Pyrimidine metabolism_Homo sapiens_hsa002400.67175515
71Base excision repair_Homo sapiens_hsa034100.67154821
72Salivary secretion_Homo sapiens_hsa049700.66600095
73Fatty acid metabolism_Homo sapiens_hsa012120.64367433
74Arachidonic acid metabolism_Homo sapiens_hsa005900.62438299
75Calcium signaling pathway_Homo sapiens_hsa040200.60569527
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60182327
77Parkinsons disease_Homo sapiens_hsa050120.59688015
78Metabolic pathways_Homo sapiens_hsa011000.59262243
79p53 signaling pathway_Homo sapiens_hsa041150.57906488
80Proteasome_Homo sapiens_hsa030500.56132313
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.53529617
82Vitamin digestion and absorption_Homo sapiens_hsa049770.52826010
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52369775
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.45515136
85DNA replication_Homo sapiens_hsa030300.44030266
86Fatty acid biosynthesis_Homo sapiens_hsa000610.39811181
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.37965199
88Fat digestion and absorption_Homo sapiens_hsa049750.37690089
89Fatty acid elongation_Homo sapiens_hsa000620.36682955
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36672856
91Spliceosome_Homo sapiens_hsa030400.36466325
92Hedgehog signaling pathway_Homo sapiens_hsa043400.36315294
93TGF-beta signaling pathway_Homo sapiens_hsa043500.36098619
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36012802
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35572688
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33265189
97Dorso-ventral axis formation_Homo sapiens_hsa043200.32352869
98Ovarian steroidogenesis_Homo sapiens_hsa049130.30623560
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30512812
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.30055516

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