ZNF470

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.87338397
2detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.00243946
3nonmotile primary cilium assembly (GO:0035058)3.91457714
4indolalkylamine metabolic process (GO:0006586)3.70525270
5pyrimidine nucleobase catabolic process (GO:0006208)3.67727455
6neural tube formation (GO:0001841)3.66274923
7gamma-aminobutyric acid transport (GO:0015812)3.61563878
8fucose catabolic process (GO:0019317)3.56530532
9L-fucose metabolic process (GO:0042354)3.56530532
10L-fucose catabolic process (GO:0042355)3.56530532
11tryptophan catabolic process (GO:0006569)3.48226406
12indole-containing compound catabolic process (GO:0042436)3.48226406
13indolalkylamine catabolic process (GO:0046218)3.48226406
14retinal cone cell development (GO:0046549)3.46407105
15reflex (GO:0060004)3.43640920
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40878115
17detection of light stimulus involved in visual perception (GO:0050908)3.32568973
18detection of light stimulus involved in sensory perception (GO:0050962)3.32568973
19kynurenine metabolic process (GO:0070189)3.31042349
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22240547
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.22240547
22regulation of translation, ncRNA-mediated (GO:0045974)3.22240547
23postsynaptic membrane organization (GO:0001941)3.16674089
24response to pheromone (GO:0019236)3.14015342
25photoreceptor cell maintenance (GO:0045494)3.13867807
26presynaptic membrane assembly (GO:0097105)3.13805568
27kidney morphogenesis (GO:0060993)3.11037891
28epithelial cilium movement (GO:0003351)3.10998610
29cilium or flagellum-dependent cell motility (GO:0001539)3.10053171
30indole-containing compound metabolic process (GO:0042430)3.06805142
31behavioral response to ethanol (GO:0048149)3.05815105
32transmission of nerve impulse (GO:0019226)3.03566068
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02358219
34nucleobase catabolic process (GO:0046113)3.00749384
35protein polyglutamylation (GO:0018095)2.95970228
36cellular ketone body metabolic process (GO:0046950)2.94328957
37tryptophan metabolic process (GO:0006568)2.93525394
38presynaptic membrane organization (GO:0097090)2.93290306
39cilium morphogenesis (GO:0060271)2.93221380
40cilium organization (GO:0044782)2.93083856
41axoneme assembly (GO:0035082)2.92291428
42primary amino compound metabolic process (GO:1901160)2.92122281
43neuronal action potential (GO:0019228)2.92086409
44inner ear receptor stereocilium organization (GO:0060122)2.91796677
45negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90639241
46sulfation (GO:0051923)2.90570370
47cilium assembly (GO:0042384)2.87955005
48serotonin metabolic process (GO:0042428)2.87144395
49regulation of action potential (GO:0098900)2.83536157
50protein localization to cilium (GO:0061512)2.82841814
51negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79977004
52regulation of cilium movement (GO:0003352)2.79736971
53piRNA metabolic process (GO:0034587)2.79698634
54negative regulation of telomere maintenance (GO:0032205)2.79553655
55regulation of neurotransmitter uptake (GO:0051580)2.78240055
56cilium movement (GO:0003341)2.78097578
57protein localization to synapse (GO:0035418)2.69476443
58regulation of hippo signaling (GO:0035330)2.68920024
59auditory receptor cell stereocilium organization (GO:0060088)2.68234811
60photoreceptor cell development (GO:0042461)2.68040229
61startle response (GO:0001964)2.67900411
62ketone body metabolic process (GO:1902224)2.66453737
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62924037
64cAMP catabolic process (GO:0006198)2.61576708
65amine catabolic process (GO:0009310)2.59596036
66cellular biogenic amine catabolic process (GO:0042402)2.59596036
67negative regulation of mast cell activation (GO:0033004)2.58914187
68platelet dense granule organization (GO:0060155)2.58194456
69dendritic spine morphogenesis (GO:0060997)2.58023435
70detection of mechanical stimulus involved in sensory perception (GO:0050974)2.56891398
71regulation of gene silencing by RNA (GO:0060966)2.56710914
72regulation of posttranscriptional gene silencing (GO:0060147)2.56710914
73regulation of gene silencing by miRNA (GO:0060964)2.56710914
74neuron cell-cell adhesion (GO:0007158)2.55753617
75intraciliary transport (GO:0042073)2.55310506
76membrane depolarization during action potential (GO:0086010)2.53798043
77protein K11-linked deubiquitination (GO:0035871)2.52771615
78rhodopsin mediated signaling pathway (GO:0016056)2.50315592
79auditory behavior (GO:0031223)2.49860469
80somite development (GO:0061053)2.49328527
81regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48973287
82neuronal action potential propagation (GO:0019227)2.47556532
83negative regulation of systemic arterial blood pressure (GO:0003085)2.47541509
84regulation of collateral sprouting (GO:0048670)2.45881298
85regulation of telomere maintenance (GO:0032204)2.44236044
86synapse assembly (GO:0007416)2.43766819
87cyclic nucleotide catabolic process (GO:0009214)2.42412657
88spinal cord motor neuron differentiation (GO:0021522)2.41799223
89synaptic transmission, cholinergic (GO:0007271)2.41448587
90retinal ganglion cell axon guidance (GO:0031290)2.41443941
91righting reflex (GO:0060013)2.41170466
92adaptation of signaling pathway (GO:0023058)2.40830983
93cornea development in camera-type eye (GO:0061303)2.39308470
94hindbrain development (GO:0030902)2.39069828
95negative regulation of appetite (GO:0032099)2.38544360
96negative regulation of response to food (GO:0032096)2.38544360
97tachykinin receptor signaling pathway (GO:0007217)2.37278597
98DNA methylation involved in gamete generation (GO:0043046)2.36836569
99cellular component assembly involved in morphogenesis (GO:0010927)2.36800588
100positive regulation of oligodendrocyte differentiation (GO:0048714)2.36639297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.73112742
2GBX2_23144817_ChIP-Seq_PC3_Human3.47731326
3* ZNF274_21170338_ChIP-Seq_K562_Hela3.28582926
4VDR_22108803_ChIP-Seq_LS180_Human2.89606039
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78006978
6IGF1R_20145208_ChIP-Seq_DFB_Human2.72687177
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71026111
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42361120
9TAF15_26573619_Chip-Seq_HEK293_Human2.38375680
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37977733
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36201425
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19376797
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16432079
14P300_19829295_ChIP-Seq_ESCs_Human2.16143174
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.03682752
16FUS_26573619_Chip-Seq_HEK293_Human1.99265885
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.90105419
18EWS_26573619_Chip-Seq_HEK293_Human1.89831773
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85378912
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83691965
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81544333
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77900416
23STAT3_23295773_ChIP-Seq_U87_Human1.74303492
24SMAD4_21799915_ChIP-Seq_A2780_Human1.74052057
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73867169
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.73081671
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72466314
28ER_23166858_ChIP-Seq_MCF-7_Human1.70436150
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69094646
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65323261
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63049455
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63049455
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61992671
34TCF4_23295773_ChIP-Seq_U87_Human1.56597101
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56400092
36CBP_20019798_ChIP-Seq_JUKART_Human1.56400092
37REST_21632747_ChIP-Seq_MESCs_Mouse1.56326444
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55613052
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54778678
40AR_21572438_ChIP-Seq_LNCaP_Human1.54472057
41* BCAT_22108803_ChIP-Seq_LS180_Human1.54123395
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.51445730
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.47432812
44AR_25329375_ChIP-Seq_VCAP_Human1.46653036
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42826924
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41872973
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41564085
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40432590
49RNF2_27304074_Chip-Seq_NSC_Mouse1.39514040
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39325220
51IRF1_19129219_ChIP-ChIP_H3396_Human1.38565183
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34922689
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33805868
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33552899
55* TCF4_22108803_ChIP-Seq_LS180_Human1.32164944
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32092407
57RUNX2_22187159_ChIP-Seq_PCA_Human1.32080730
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31763670
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28388822
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.26781507
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24691247
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24688933
63TP53_22573176_ChIP-Seq_HFKS_Human1.24649486
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.23049304
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.22168237
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20944864
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.20944469
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.20591495
69* SOX2_19829295_ChIP-Seq_ESCs_Human1.20394265
70* NANOG_19829295_ChIP-Seq_ESCs_Human1.20394265
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20192951
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.19175192
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14485838
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14199189
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.10649230
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.10640164
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10453766
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10384983
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10220708
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09906149
81P53_22387025_ChIP-Seq_ESCs_Mouse1.09306561
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.08608116
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07491843
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07311570
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06943208
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06595175
87JUN_21703547_ChIP-Seq_K562_Human1.05768254
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.05199661
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04769280
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.04464450
91CDX2_22108803_ChIP-Seq_LS180_Human1.03576235
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03499602
93TP53_16413492_ChIP-PET_HCT116_Human1.03035351
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.02576687
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02372549
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.02372549
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.01803494
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00966914
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00589127
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00409511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.51779451
2MP0002102_abnormal_ear_morphology2.74281667
3MP0005551_abnormal_eye_electrophysiolog2.60996874
4MP0003880_abnormal_central_pattern2.52247545
5MP0008877_abnormal_DNA_methylation2.49032381
6MP0009046_muscle_twitch2.30162852
7MP0001968_abnormal_touch/_nociception2.23907864
8MP0006292_abnormal_olfactory_placode2.14918030
9MP0002736_abnormal_nociception_after2.09075026
10MP0003195_calcinosis2.08597588
11MP0001984_abnormal_olfaction2.06910843
12MP0009745_abnormal_behavioral_response2.05644290
13MP0006276_abnormal_autonomic_nervous2.02376834
14MP0000778_abnormal_nervous_system2.00064602
15MP0003136_yellow_coat_color1.98778638
16MP0002653_abnormal_ependyma_morphology1.97355422
17MP0004142_abnormal_muscle_tone1.96274328
18MP0002272_abnormal_nervous_system1.88126556
19MP0001486_abnormal_startle_reflex1.83596060
20MP0002837_dystrophic_cardiac_calcinosis1.75611764
21MP0006072_abnormal_retinal_apoptosis1.74569221
22MP0002638_abnormal_pupillary_reflex1.73371207
23MP0004133_heterotaxia1.72579146
24MP0002572_abnormal_emotion/affect_behav1.72024552
25MP0001501_abnormal_sleep_pattern1.71593775
26MP0005253_abnormal_eye_physiology1.68754622
27MP0003635_abnormal_synaptic_transmissio1.67380457
28MP0002938_white_spotting1.65503787
29MP0008872_abnormal_physiological_respon1.65328031
30MP0000631_abnormal_neuroendocrine_gland1.64507713
31MP0000427_abnormal_hair_cycle1.64182089
32MP0004043_abnormal_pH_regulation1.62947120
33MP0001529_abnormal_vocalization1.62333626
34MP0001485_abnormal_pinna_reflex1.62229856
35MP0002557_abnormal_social/conspecific_i1.61779473
36MP0004885_abnormal_endolymph1.61017758
37MP0003787_abnormal_imprinting1.55559361
38MP0002064_seizures1.53495083
39MP0002735_abnormal_chemical_nociception1.52097099
40MP0005645_abnormal_hypothalamus_physiol1.50955649
41MP0002067_abnormal_sensory_capabilities1.48752995
42MP0003646_muscle_fatigue1.48404805
43MP0004145_abnormal_muscle_electrophysio1.46347288
44MP0002063_abnormal_learning/memory/cond1.46268538
45MP0003890_abnormal_embryonic-extraembry1.44374461
46MP0005646_abnormal_pituitary_gland1.43336435
47MP0005386_behavior/neurological_phenoty1.40679335
48MP0004924_abnormal_behavior1.40679335
49MP0004742_abnormal_vestibular_system1.31894734
50MP0004859_abnormal_synaptic_plasticity1.31753113
51MP0010386_abnormal_urinary_bladder1.30067452
52MP0003283_abnormal_digestive_organ1.27906066
53MP0001970_abnormal_pain_threshold1.25526081
54MP0001986_abnormal_taste_sensitivity1.24470637
55MP0002734_abnormal_mechanical_nocicepti1.22048018
56MP0008789_abnormal_olfactory_epithelium1.20206799
57MP0002752_abnormal_somatic_nervous1.19580899
58MP0002184_abnormal_innervation1.19112208
59MP0005174_abnormal_tail_pigmentation1.19097437
60MP0002876_abnormal_thyroid_physiology1.18696188
61MP0005195_abnormal_posterior_eye1.18011755
62MP0005499_abnormal_olfactory_system1.17597039
63MP0005394_taste/olfaction_phenotype1.17597039
64MP0002733_abnormal_thermal_nociception1.15399013
65MP0000955_abnormal_spinal_cord1.14999259
66MP0002882_abnormal_neuron_morphology1.10896718
67MP0002928_abnormal_bile_duct1.10784474
68MP0000383_abnormal_hair_follicle1.06466229
69MP0001905_abnormal_dopamine_level1.04142408
70MP0002095_abnormal_skin_pigmentation1.02912856
71MP0002229_neurodegeneration1.01971292
72MP0003119_abnormal_digestive_system1.01517928
73MP0000026_abnormal_inner_ear1.00320436
74MP0004270_analgesia1.00209481
75MP0002138_abnormal_hepatobiliary_system0.98938010
76MP0003937_abnormal_limbs/digits/tail_de0.98772704
77MP0001440_abnormal_grooming_behavior0.97924655
78MP0008875_abnormal_xenobiotic_pharmacok0.97254069
79MP0003011_delayed_dark_adaptation0.96774788
80MP0002909_abnormal_adrenal_gland0.93541162
81MP0002234_abnormal_pharynx_morphology0.93538432
82MP0003121_genomic_imprinting0.92868605
83MP0003122_maternal_imprinting0.92324006
84MP0001293_anophthalmia0.92110611
85MP0005423_abnormal_somatic_nervous0.90485212
86MP0002751_abnormal_autonomic_nervous0.89781656
87MP0001502_abnormal_circadian_rhythm0.88141034
88MP0000372_irregular_coat_pigmentation0.87188115
89MP0003698_abnormal_male_reproductive0.84391992
90MP0002822_catalepsy0.84021928
91MP0001963_abnormal_hearing_physiology0.83360721
92MP0005187_abnormal_penis_morphology0.82789280
93MP0000647_abnormal_sebaceous_gland0.82574787
94MP0000230_abnormal_systemic_arterial0.82548454
95MP0003137_abnormal_impulse_conducting0.81961293
96MP0003878_abnormal_ear_physiology0.81499423
97MP0005377_hearing/vestibular/ear_phenot0.81499423
98MP0004215_abnormal_myocardial_fiber0.79884556
99MP0005084_abnormal_gallbladder_morpholo0.78984112
100MP0005391_vision/eye_phenotype0.78237663

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.58012170
2Abnormality of midbrain morphology (HP:0002418)4.39864187
3Molar tooth sign on MRI (HP:0002419)4.39864187
4Pancreatic fibrosis (HP:0100732)4.30810928
5True hermaphroditism (HP:0010459)4.18736577
6Nephronophthisis (HP:0000090)3.80099427
7Hyperventilation (HP:0002883)3.77597035
8Medial flaring of the eyebrow (HP:0010747)3.54837284
9Abnormality of the renal medulla (HP:0100957)3.35117534
10Abnormality of the renal cortex (HP:0011035)3.24848451
11Congenital stationary night blindness (HP:0007642)3.19044027
12Chronic hepatic failure (HP:0100626)3.13866274
13Gait imbalance (HP:0002141)3.08948136
14Progressive cerebellar ataxia (HP:0002073)3.05382395
15Type II lissencephaly (HP:0007260)2.98648438
16Congenital primary aphakia (HP:0007707)2.93613268
17Cystic liver disease (HP:0006706)2.85982617
18Gaze-evoked nystagmus (HP:0000640)2.82099003
19Abolished electroretinogram (ERG) (HP:0000550)2.81331309
20Broad-based gait (HP:0002136)2.78762769
21Aplasia/Hypoplasia of the tibia (HP:0005772)2.78203258
22Inability to walk (HP:0002540)2.78182089
23Nephrogenic diabetes insipidus (HP:0009806)2.77003193
24Febrile seizures (HP:0002373)2.76873364
25Genetic anticipation (HP:0003743)2.74315017
26Tubular atrophy (HP:0000092)2.73206134
27Attenuation of retinal blood vessels (HP:0007843)2.72819001
28Genital tract atresia (HP:0001827)2.58863791
29Progressive inability to walk (HP:0002505)2.52980850
30Pendular nystagmus (HP:0012043)2.50092766
31Vaginal atresia (HP:0000148)2.48822547
32Anencephaly (HP:0002323)2.48042882
33Protruding tongue (HP:0010808)2.45084573
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.44440771
35Keratoconus (HP:0000563)2.44272207
36Increased corneal curvature (HP:0100692)2.44272207
37Renal cortical cysts (HP:0000803)2.40350838
38Sclerocornea (HP:0000647)2.37826408
39Polydipsia (HP:0001959)2.37301766
40Abnormal drinking behavior (HP:0030082)2.37301766
41Absent speech (HP:0001344)2.34019228
42Abnormality of alanine metabolism (HP:0010916)2.30849137
43Hyperalaninemia (HP:0003348)2.30849137
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30849137
45Congenital hepatic fibrosis (HP:0002612)2.30257506
46Cerebellar dysplasia (HP:0007033)2.29318428
47Colon cancer (HP:0003003)2.27173166
48Lissencephaly (HP:0001339)2.26642621
49Intestinal atresia (HP:0011100)2.26235323
50Focal motor seizures (HP:0011153)2.24250428
51Postaxial foot polydactyly (HP:0001830)2.21816181
52Drooling (HP:0002307)2.20124570
53Clumsiness (HP:0002312)2.18445035
54Oligodactyly (hands) (HP:0001180)2.17811305
55Optic nerve hypoplasia (HP:0000609)2.17421767
56Hemiparesis (HP:0001269)2.15373646
57Focal seizures (HP:0007359)2.14452295
58Postaxial hand polydactyly (HP:0001162)2.13943386
59Retinal dysplasia (HP:0007973)2.13819676
60Poor coordination (HP:0002370)2.12178754
61Short tibia (HP:0005736)2.05458656
62Bile duct proliferation (HP:0001408)2.05266142
63Abnormal biliary tract physiology (HP:0012439)2.05266142
64Fair hair (HP:0002286)2.04456538
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03513110
66Decreased central vision (HP:0007663)2.03367605
67Male pseudohermaphroditism (HP:0000037)2.02069536
68Dialeptic seizures (HP:0011146)1.99146183
69Furrowed tongue (HP:0000221)1.98946976
70Epileptic encephalopathy (HP:0200134)1.96904314
71Preaxial hand polydactyly (HP:0001177)1.94675472
72Excessive salivation (HP:0003781)1.94345211
73Absent/shortened dynein arms (HP:0200106)1.92014961
74Dynein arm defect of respiratory motile cilia (HP:0012255)1.92014961
75Abnormal ciliary motility (HP:0012262)1.90449098
76Bony spicule pigmentary retinopathy (HP:0007737)1.89708570
77Stomach cancer (HP:0012126)1.89498192
78Abnormality of the labia minora (HP:0012880)1.89442950
79Polyuria (HP:0000103)1.89052775
80Narrow forehead (HP:0000341)1.87984834
81Abnormality of macular pigmentation (HP:0008002)1.86721460
82Pachygyria (HP:0001302)1.85722738
83Specific learning disability (HP:0001328)1.83664093
84Chorioretinal atrophy (HP:0000533)1.82462874
85Large for gestational age (HP:0001520)1.80777620
86Limb dystonia (HP:0002451)1.79933720
87Abnormal rod and cone electroretinograms (HP:0008323)1.79261167
88Dandy-Walker malformation (HP:0001305)1.78757004
89Atonic seizures (HP:0010819)1.77049442
90Polyphagia (HP:0002591)1.76994929
91Short foot (HP:0001773)1.74913823
92Astigmatism (HP:0000483)1.73102816
93Hypothermia (HP:0002045)1.71611312
94Tubulointerstitial abnormality (HP:0001969)1.71429549
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71320542
96Abnormal respiratory motile cilium morphology (HP:0005938)1.68860807
97Abnormal respiratory epithelium morphology (HP:0012253)1.68860807
98Septo-optic dysplasia (HP:0100842)1.68183233
99Congenital, generalized hypertrichosis (HP:0004540)1.66475760
100Highly arched eyebrow (HP:0002553)1.65165954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.65455583
2BMPR1B3.48492636
3CASK2.86074793
4ADRBK22.66892569
5WNK32.65421195
6MAP3K42.62866878
7ZAK2.56104640
8MAP4K22.46241284
9NUAK12.40291630
10MARK12.11936357
11INSRR2.11779666
12GRK11.98736259
13ACVR1B1.94569680
14MAPK131.89080984
15WNK41.77936061
16PINK11.70845143
17LATS11.62870524
18MAP2K71.57034519
19PAK31.54946288
20STK38L1.48688106
21TAOK31.47226953
22TRIM281.42802728
23DAPK21.40530228
24NTRK31.38895473
25TNIK1.38642955
26BCR1.32191774
27NTRK21.31110908
28PLK21.29381990
29PNCK1.24235435
30TGFBR11.23878066
31EPHA41.22453634
32MUSK1.18030372
33OXSR11.17959010
34MKNK21.16758662
35STK391.14978371
36PRKCE1.05007299
37TLK11.03956961
38CAMKK21.03927511
39PRKCG1.02424571
40DYRK21.01764492
41CSNK1G21.00032720
42ADRBK10.98670453
43FGFR20.89096923
44AKT30.86999983
45CSNK1G10.85051440
46CSNK1A1L0.77684654
47TIE10.76763386
48CSNK1G30.74152182
49PTK2B0.70935538
50STK30.68404801
51PIK3CA0.68312891
52CAMK2A0.67231526
53EPHB20.66937736
54BCKDK0.64085208
55SGK20.63924602
56TXK0.63636526
57OBSCN0.57870996
58SGK4940.56576233
59SGK2230.56576233
60STK110.54709211
61DYRK1A0.54275221
62PKN10.53108230
63CSNK1D0.52643344
64PHKG10.52640978
65PHKG20.52640978
66MINK10.50283458
67SIK20.50275606
68CAMK10.49886859
69PRKACA0.49238660
70WNK10.49129090
71ERBB30.48063018
72VRK10.47921839
73MKNK10.47652413
74PLK30.47443409
75MAP2K40.47400905
76TEC0.45920288
77PAK60.44211192
78MAPK150.42457238
79PIK3CG0.41933784
80STK160.41184355
81PRKCQ0.39419676
82TNK20.38910399
83PRKG10.38804167
84ERBB20.38121490
85CAMK1G0.38072856
86CDK50.37411504
87BRSK20.36810185
88PRKCH0.36237941
89CSNK1A10.35999076
90CDK190.35497332
91NEK20.35427826
92PLK40.35333531
93CDK30.35289209
94PRKCZ0.35265795
95STK380.35100143
96FER0.34107106
97PRKAA10.33950097
98NLK0.33526765
99PRKCA0.32325764
100TAF10.32087383

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.16360179
2Nicotine addiction_Homo sapiens_hsa050332.97841916
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.57552119
4Butanoate metabolism_Homo sapiens_hsa006502.52225779
5Linoleic acid metabolism_Homo sapiens_hsa005912.44132934
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42420896
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38939037
8Nitrogen metabolism_Homo sapiens_hsa009102.27263971
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.18516139
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03222047
11Morphine addiction_Homo sapiens_hsa050321.91278584
12Selenocompound metabolism_Homo sapiens_hsa004501.90994895
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88306297
14Tryptophan metabolism_Homo sapiens_hsa003801.86449714
15Taste transduction_Homo sapiens_hsa047421.84852839
16Ether lipid metabolism_Homo sapiens_hsa005651.76004897
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69663159
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.69633753
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61998046
20GABAergic synapse_Homo sapiens_hsa047271.57257678
21Protein export_Homo sapiens_hsa030601.56719138
22Caffeine metabolism_Homo sapiens_hsa002321.55566539
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50833530
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50518958
25Circadian entrainment_Homo sapiens_hsa047131.49427064
26Glutamatergic synapse_Homo sapiens_hsa047241.46218155
27Insulin secretion_Homo sapiens_hsa049111.45157173
28Basal transcription factors_Homo sapiens_hsa030221.43316726
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.42981402
30Olfactory transduction_Homo sapiens_hsa047401.41667109
31Oxidative phosphorylation_Homo sapiens_hsa001901.34435209
32ABC transporters_Homo sapiens_hsa020101.32286140
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30847654
34Propanoate metabolism_Homo sapiens_hsa006401.29973430
35Fanconi anemia pathway_Homo sapiens_hsa034601.29607153
36Serotonergic synapse_Homo sapiens_hsa047261.28816392
37Homologous recombination_Homo sapiens_hsa034401.28298642
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26223483
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25080816
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.21218302
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17466442
42Regulation of autophagy_Homo sapiens_hsa041401.09742260
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09487418
44Cocaine addiction_Homo sapiens_hsa050301.08332471
45Dopaminergic synapse_Homo sapiens_hsa047281.05353862
46Chemical carcinogenesis_Homo sapiens_hsa052041.03063370
47Calcium signaling pathway_Homo sapiens_hsa040201.02500750
48Peroxisome_Homo sapiens_hsa041461.01794994
49Salivary secretion_Homo sapiens_hsa049700.98002768
50Parkinsons disease_Homo sapiens_hsa050120.95852342
51beta-Alanine metabolism_Homo sapiens_hsa004100.95130246
52Retinol metabolism_Homo sapiens_hsa008300.93702965
53RNA polymerase_Homo sapiens_hsa030200.93306686
54Cardiac muscle contraction_Homo sapiens_hsa042600.91025393
55Dorso-ventral axis formation_Homo sapiens_hsa043200.90258376
56RNA degradation_Homo sapiens_hsa030180.84322017
57Arachidonic acid metabolism_Homo sapiens_hsa005900.84246245
58Histidine metabolism_Homo sapiens_hsa003400.82891208
59Amphetamine addiction_Homo sapiens_hsa050310.82685526
60Hedgehog signaling pathway_Homo sapiens_hsa043400.81280080
61Glycerolipid metabolism_Homo sapiens_hsa005610.79419303
62Ovarian steroidogenesis_Homo sapiens_hsa049130.79351589
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78058062
64Long-term depression_Homo sapiens_hsa047300.77200008
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76770659
66Cholinergic synapse_Homo sapiens_hsa047250.73558001
67cAMP signaling pathway_Homo sapiens_hsa040240.71696094
68Huntingtons disease_Homo sapiens_hsa050160.70530025
69Circadian rhythm_Homo sapiens_hsa047100.69184391
70Steroid biosynthesis_Homo sapiens_hsa001000.68796885
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.65679329
72Axon guidance_Homo sapiens_hsa043600.62625345
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61072931
74Oxytocin signaling pathway_Homo sapiens_hsa049210.59923889
75Collecting duct acid secretion_Homo sapiens_hsa049660.57974993
76Gastric acid secretion_Homo sapiens_hsa049710.57212687
77Basal cell carcinoma_Homo sapiens_hsa052170.57168729
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.50399665
79Alzheimers disease_Homo sapiens_hsa050100.49600679
80Lysine degradation_Homo sapiens_hsa003100.49320293
81Synaptic vesicle cycle_Homo sapiens_hsa047210.48845717
82One carbon pool by folate_Homo sapiens_hsa006700.48767639
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48663005
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48433214
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45884824
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44710919
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44200320
88Metabolic pathways_Homo sapiens_hsa011000.43519169
89Type II diabetes mellitus_Homo sapiens_hsa049300.43101424
90Renin secretion_Homo sapiens_hsa049240.42638827
91Purine metabolism_Homo sapiens_hsa002300.41488161
92Hippo signaling pathway_Homo sapiens_hsa043900.40216967
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40216076
94Mineral absorption_Homo sapiens_hsa049780.37363075
95Asthma_Homo sapiens_hsa053100.35284043
96Fat digestion and absorption_Homo sapiens_hsa049750.34263147
97Fatty acid metabolism_Homo sapiens_hsa012120.30967663
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30027704
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.29131473
100Ras signaling pathway_Homo sapiens_hsa040140.29078287

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