ZNF454

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)5.16991641
2pyrimidine nucleobase catabolic process (GO:0006208)5.02726977
3behavioral response to nicotine (GO:0035095)4.51725846
4presynaptic membrane assembly (GO:0097105)4.42677955
5nucleobase catabolic process (GO:0046113)4.16823103
6negative regulation of synaptic transmission, GABAergic (GO:0032229)4.06808253
7proline transport (GO:0015824)3.95174678
8presynaptic membrane organization (GO:0097090)3.94274577
9transmission of nerve impulse (GO:0019226)3.77209535
10protein-cofactor linkage (GO:0018065)3.73965299
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.73285441
12postsynaptic membrane organization (GO:0001941)3.67128841
13neuron cell-cell adhesion (GO:0007158)3.63302978
14negative regulation of telomere maintenance (GO:0032205)3.62844280
15L-fucose catabolic process (GO:0042355)3.62194861
16fucose catabolic process (GO:0019317)3.62194861
17L-fucose metabolic process (GO:0042354)3.62194861
18vocalization behavior (GO:0071625)3.55735726
19regulation of action potential (GO:0098900)3.50016963
20negative regulation of multicellular organism growth (GO:0040015)3.45629155
21nonmotile primary cilium assembly (GO:0035058)3.45522415
22protein polyglutamylation (GO:0018095)3.41236499
23kynurenine metabolic process (GO:0070189)3.25520746
24axoneme assembly (GO:0035082)3.25150910
25regulation of memory T cell differentiation (GO:0043380)3.23330991
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22354637
27regulation of collateral sprouting (GO:0048670)3.21249748
28synaptic transmission, cholinergic (GO:0007271)3.17996763
29regulation of development, heterochronic (GO:0040034)3.12257870
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11638607
31regulation of timing of cell differentiation (GO:0048505)3.11197081
32response to pheromone (GO:0019236)3.08460299
33establishment of mitochondrion localization (GO:0051654)3.07263797
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04517959
35protein localization to synapse (GO:0035418)3.04292509
36regulation of telomere maintenance (GO:0032204)3.03691134
37startle response (GO:0001964)3.02302254
38epithelial cilium movement (GO:0003351)3.02288471
39calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.02073992
40indole-containing compound catabolic process (GO:0042436)2.99971091
41indolalkylamine catabolic process (GO:0046218)2.99971091
42tryptophan catabolic process (GO:0006569)2.99971091
43cerebellar Purkinje cell differentiation (GO:0021702)2.98422440
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93599664
45regulation of short-term neuronal synaptic plasticity (GO:0048172)2.92915172
46neuronal action potential propagation (GO:0019227)2.90443713
47sex differentiation (GO:0007548)2.86546679
48detection of light stimulus involved in sensory perception (GO:0050962)2.85967121
49detection of light stimulus involved in visual perception (GO:0050908)2.85967121
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77977817
51neurotransmitter-gated ion channel clustering (GO:0072578)2.76299734
52glutamate receptor signaling pathway (GO:0007215)2.75891560
53synapse assembly (GO:0007416)2.75848932
54synaptic vesicle maturation (GO:0016188)2.74968741
55protein localization to cilium (GO:0061512)2.74614380
56neuronal action potential (GO:0019228)2.72095836
57tryptophan metabolic process (GO:0006568)2.71588275
58indolalkylamine metabolic process (GO:0006586)2.71323784
59synaptic transmission, glutamatergic (GO:0035249)2.69413083
60behavioral response to ethanol (GO:0048149)2.67995990
61retinal cone cell development (GO:0046549)2.67636736
62cellular ketone body metabolic process (GO:0046950)2.66117064
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.65774938
64adult walking behavior (GO:0007628)2.64105141
65inner ear receptor stereocilium organization (GO:0060122)2.61493627
66ionotropic glutamate receptor signaling pathway (GO:0035235)2.61086869
67olfactory bulb development (GO:0021772)2.59439897
68C4-dicarboxylate transport (GO:0015740)2.59121845
69cilium movement (GO:0003341)2.58644406
70photoreceptor cell maintenance (GO:0045494)2.54849226
71intraciliary transport (GO:0042073)2.54830306
72ubiquinone metabolic process (GO:0006743)2.53841237
73cilium morphogenesis (GO:0060271)2.52159015
74reflex (GO:0060004)2.51928630
75cellular biogenic amine catabolic process (GO:0042402)2.50834293
76amine catabolic process (GO:0009310)2.50834293
77central nervous system projection neuron axonogenesis (GO:0021952)2.50577797
78seminiferous tubule development (GO:0072520)2.50533855
79regulation of cilium movement (GO:0003352)2.49812171
80cell proliferation in forebrain (GO:0021846)2.47379968
81regulation of sarcomere organization (GO:0060297)2.46756632
82glycosphingolipid biosynthetic process (GO:0006688)2.46669440
83neural tube formation (GO:0001841)2.45809416
84negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.44743455
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.44743455
86regulation of translation, ncRNA-mediated (GO:0045974)2.44743455
87positive regulation of action potential (GO:0045760)2.44573069
88auditory receptor cell stereocilium organization (GO:0060088)2.44558934
89tachykinin receptor signaling pathway (GO:0007217)2.44428504
90positive regulation of synapse assembly (GO:0051965)2.44106990
91photoreceptor cell development (GO:0042461)2.43043467
92head development (GO:0060322)2.41367183
93substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41004443
94substrate-independent telencephalic tangential migration (GO:0021826)2.41004443
95alanine transport (GO:0032328)2.40851865
96cilium organization (GO:0044782)2.40811358
97negative regulation of mast cell activation (GO:0033004)2.39025350
98limb bud formation (GO:0060174)2.36870860
99cilium assembly (GO:0042384)2.36758591
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.35819898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.74237657
2GBX2_23144817_ChIP-Seq_PC3_Human3.61190865
3EZH2_22144423_ChIP-Seq_EOC_Human3.27951310
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15024194
5IGF1R_20145208_ChIP-Seq_DFB_Human3.14596901
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88965260
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85142963
8VDR_22108803_ChIP-Seq_LS180_Human2.83651486
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54503792
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47909627
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41749041
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34608996
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30678971
14TAF15_26573619_Chip-Seq_HEK293_Human2.29753196
15FUS_26573619_Chip-Seq_HEK293_Human2.26684203
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.24898877
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01490214
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.93638868
19P300_19829295_ChIP-Seq_ESCs_Human1.93063189
20EWS_26573619_Chip-Seq_HEK293_Human1.89739928
21REST_21632747_ChIP-Seq_MESCs_Mouse1.77044278
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75929013
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74747809
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73319280
25ER_23166858_ChIP-Seq_MCF-7_Human1.70940486
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68433753
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.67048316
28SMAD4_21799915_ChIP-Seq_A2780_Human1.58501013
29IRF1_19129219_ChIP-ChIP_H3396_Human1.58294315
30BCAT_22108803_ChIP-Seq_LS180_Human1.57511305
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.57304051
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56049068
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55418359
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53768563
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53544009
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53399002
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52001759
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51974333
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51963651
40AR_25329375_ChIP-Seq_VCAP_Human1.46576601
41STAT3_23295773_ChIP-Seq_U87_Human1.45555476
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44483690
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41889784
44CBP_20019798_ChIP-Seq_JUKART_Human1.41889784
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41504739
46RNF2_27304074_Chip-Seq_NSC_Mouse1.41195133
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.40892477
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37686345
49TCF4_23295773_ChIP-Seq_U87_Human1.36016020
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35630731
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35576912
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35093967
53TP53_22573176_ChIP-Seq_HFKS_Human1.32271953
54RUNX2_22187159_ChIP-Seq_PCA_Human1.31973190
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30968889
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30257401
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.29880733
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.26220891
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25783038
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23108185
61TCF4_22108803_ChIP-Seq_LS180_Human1.20975659
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20634837
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20225300
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17742294
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17536738
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17536738
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15766133
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13945122
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.12251905
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.11850501
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.11588710
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11519541
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.10716715
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.08834034
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08038660
76NANOG_19829295_ChIP-Seq_ESCs_Human1.07841922
77SOX2_19829295_ChIP-Seq_ESCs_Human1.07841922
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07407130
79MYC_18940864_ChIP-ChIP_HL60_Human1.07397136
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.07090577
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06277482
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06158261
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03678774
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.02713141
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00971836
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.98982493
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98982493
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98233651
89P53_22387025_ChIP-Seq_ESCs_Mouse0.98173624
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96550044
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.96061514
92JUN_21703547_ChIP-Seq_K562_Human0.96048863
93KDM2B_26808549_Chip-Seq_REH_Human0.95661414
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94614581
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.94562021
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94436568
97NCOR_22424771_ChIP-Seq_293T_Human0.93663143
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92889671
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92557524
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91979996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.14627981
2MP0001968_abnormal_touch/_nociception3.09703338
3MP0001529_abnormal_vocalization2.95572020
4MP0008877_abnormal_DNA_methylation2.82344748
5MP0003011_delayed_dark_adaptation2.62025016
6MP0001986_abnormal_taste_sensitivity2.50138341
7MP0002638_abnormal_pupillary_reflex2.46783595
8MP0001188_hyperpigmentation2.31744664
9MP0003880_abnormal_central_pattern2.30672664
10MP0009046_muscle_twitch2.18039023
11MP0009745_abnormal_behavioral_response2.16730297
12MP0005551_abnormal_eye_electrophysiolog2.11984285
13MP0002102_abnormal_ear_morphology2.08696042
14MP0005253_abnormal_eye_physiology2.08312098
15MP0006276_abnormal_autonomic_nervous2.07847571
16MP0004859_abnormal_synaptic_plasticity2.07498126
17MP0002272_abnormal_nervous_system2.06833048
18MP0000569_abnormal_digit_pigmentation2.06486662
19MP0006072_abnormal_retinal_apoptosis2.02561539
20MP0003635_abnormal_synaptic_transmissio2.00755982
21MP0001486_abnormal_startle_reflex1.98129178
22MP0000778_abnormal_nervous_system1.82761484
23MP0004885_abnormal_endolymph1.81173606
24MP0006292_abnormal_olfactory_placode1.80751557
25MP0003787_abnormal_imprinting1.79915290
26MP0002653_abnormal_ependyma_morphology1.78580970
27MP0002572_abnormal_emotion/affect_behav1.72848613
28MP0002734_abnormal_mechanical_nocicepti1.65212944
29MP0002063_abnormal_learning/memory/cond1.63738207
30MP0002735_abnormal_chemical_nociception1.60262646
31MP0008789_abnormal_olfactory_epithelium1.59611531
32MP0005084_abnormal_gallbladder_morpholo1.59023675
33MP0004043_abnormal_pH_regulation1.58197339
34MP0001984_abnormal_olfaction1.57689826
35MP0004270_analgesia1.57268483
36MP0002733_abnormal_thermal_nociception1.56350060
37MP0002064_seizures1.55045860
38MP0004924_abnormal_behavior1.52886434
39MP0005386_behavior/neurological_phenoty1.52886434
40MP0003122_maternal_imprinting1.50220930
41MP0005499_abnormal_olfactory_system1.50001460
42MP0005394_taste/olfaction_phenotype1.50001460
43MP0001970_abnormal_pain_threshold1.48281747
44MP0001501_abnormal_sleep_pattern1.45761809
45MP0004142_abnormal_muscle_tone1.41382260
46MP0000631_abnormal_neuroendocrine_gland1.39815968
47MP0002557_abnormal_social/conspecific_i1.39190324
48MP0002067_abnormal_sensory_capabilities1.35789806
49MP0002938_white_spotting1.31693118
50MP0003195_calcinosis1.26627113
51MP0003567_abnormal_fetal_cardiomyocyte1.24816784
52MP0005367_renal/urinary_system_phenotyp1.21770736
53MP0000516_abnormal_urinary_system1.21770736
54MP0000049_abnormal_middle_ear1.19848145
55MP0004133_heterotaxia1.18838589
56MP0000427_abnormal_hair_cycle1.17989000
57MP0002837_dystrophic_cardiac_calcinosis1.17348565
58MP0004147_increased_porphyrin_level1.15538587
59MP0002752_abnormal_somatic_nervous1.14320322
60MP0001905_abnormal_dopamine_level1.13917681
61MP0003137_abnormal_impulse_conducting1.10852550
62MP0003119_abnormal_digestive_system1.09530413
63MP0008872_abnormal_physiological_respon1.08858614
64MP0003121_genomic_imprinting1.08700781
65MP0002184_abnormal_innervation1.08698033
66MP0002882_abnormal_neuron_morphology1.05758286
67MP0000955_abnormal_spinal_cord1.04664732
68MP0004811_abnormal_neuron_physiology1.04203452
69MP0002751_abnormal_autonomic_nervous1.03664577
70MP0005646_abnormal_pituitary_gland1.03008961
71MP0008058_abnormal_DNA_repair1.01647763
72MP0001485_abnormal_pinna_reflex1.01375105
73MP0000372_irregular_coat_pigmentation0.99843973
74MP0005423_abnormal_somatic_nervous0.99644769
75MP0005391_vision/eye_phenotype0.98290985
76MP0004742_abnormal_vestibular_system0.97586625
77MP0005195_abnormal_posterior_eye0.96270127
78MP0003718_maternal_effect0.95189603
79MP0002277_abnormal_respiratory_mucosa0.94325898
80MP0002069_abnormal_eating/drinking_beha0.91702605
81MP0002234_abnormal_pharynx_morphology0.91633515
82MP0001963_abnormal_hearing_physiology0.91154566
83MP0001502_abnormal_circadian_rhythm0.89952303
84MP0000026_abnormal_inner_ear0.89791233
85MP0010386_abnormal_urinary_bladder0.88892886
86MP0001177_atelectasis0.87691164
87MP0002066_abnormal_motor_capabilities/c0.87406837
88MP0008875_abnormal_xenobiotic_pharmacok0.87348499
89MP0003136_yellow_coat_color0.86971862
90MP0003252_abnormal_bile_duct0.86198310
91MP0002229_neurodegeneration0.85604241
92MP0002152_abnormal_brain_morphology0.84125207
93MP0002876_abnormal_thyroid_physiology0.83824927
94MP0001440_abnormal_grooming_behavior0.82868135
95MP0002233_abnormal_nose_morphology0.81254946
96MP0003890_abnormal_embryonic-extraembry0.80328076
97MP0005645_abnormal_hypothalamus_physiol0.78762816
98MP0004085_abnormal_heartbeat0.78227358
99MP0003861_abnormal_nervous_system0.77356101
100MP0004215_abnormal_myocardial_fiber0.76218662

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)3.85978496
2Pancreatic fibrosis (HP:0100732)3.68375244
3Pancreatic cysts (HP:0001737)3.67751495
4Hyperventilation (HP:0002883)3.64903685
5Genetic anticipation (HP:0003743)3.41527828
6Progressive cerebellar ataxia (HP:0002073)3.37760082
7True hermaphroditism (HP:0010459)3.26946713
8Action tremor (HP:0002345)3.23600307
9Medial flaring of the eyebrow (HP:0010747)3.21906473
10Abnormality of midbrain morphology (HP:0002418)3.14088049
11Molar tooth sign on MRI (HP:0002419)3.14088049
12Gait imbalance (HP:0002141)3.01588476
13Focal seizures (HP:0007359)3.00994113
14Focal motor seizures (HP:0011153)2.97367176
15Dialeptic seizures (HP:0011146)2.89334513
16Absent speech (HP:0001344)2.85279462
17Gaze-evoked nystagmus (HP:0000640)2.76880855
18Nephronophthisis (HP:0000090)2.75792081
19Hyperglycinemia (HP:0002154)2.74730489
20Drooling (HP:0002307)2.74192542
21Abnormality of the labia minora (HP:0012880)2.72132907
22Lissencephaly (HP:0001339)2.71123664
23Congenital primary aphakia (HP:0007707)2.68741133
24Hypsarrhythmia (HP:0002521)2.66097783
25Abolished electroretinogram (ERG) (HP:0000550)2.63170473
26Inability to walk (HP:0002540)2.56592687
27Congenital stationary night blindness (HP:0007642)2.55310389
28EEG with generalized epileptiform discharges (HP:0011198)2.53524738
29Broad-based gait (HP:0002136)2.52170035
30Febrile seizures (HP:0002373)2.51288603
31Type II lissencephaly (HP:0007260)2.51128340
32Absence seizures (HP:0002121)2.50337314
33Excessive salivation (HP:0003781)2.47159569
34Limb dystonia (HP:0002451)2.46772316
35Epileptiform EEG discharges (HP:0011182)2.43958253
36Nephrogenic diabetes insipidus (HP:0009806)2.43929290
37Tubulointerstitial nephritis (HP:0001970)2.39250460
38Abnormality of the renal medulla (HP:0100957)2.38352068
39Polyphagia (HP:0002591)2.37412067
40Genital tract atresia (HP:0001827)2.35001943
41Abnormality of the renal cortex (HP:0011035)2.33197198
42Epileptic encephalopathy (HP:0200134)2.28763016
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.27022947
44Pachygyria (HP:0001302)2.25724353
45Keratoconus (HP:0000563)2.25290512
46Increased corneal curvature (HP:0100692)2.25290512
47Vaginal atresia (HP:0000148)2.24936891
48Cystic liver disease (HP:0006706)2.22791111
49Absent/shortened dynein arms (HP:0200106)2.22773411
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.22773411
51Hyperglycinuria (HP:0003108)2.18808143
52Hemiparesis (HP:0001269)2.17831124
53Retinal dysplasia (HP:0007973)2.17652723
54Methylmalonic acidemia (HP:0002912)2.15818252
55Narrow forehead (HP:0000341)2.12345939
56Postaxial foot polydactyly (HP:0001830)2.10198117
57Chronic hepatic failure (HP:0100626)2.08218765
58Chorioretinal atrophy (HP:0000533)2.07497717
59Postaxial hand polydactyly (HP:0001162)2.06952890
60Tubular atrophy (HP:0000092)2.05886760
61Atonic seizures (HP:0010819)2.03724213
62Urinary bladder sphincter dysfunction (HP:0002839)2.03101922
63Sclerocornea (HP:0000647)2.02149378
64Spastic tetraplegia (HP:0002510)2.01981615
65Short tibia (HP:0005736)2.01878150
66Protruding tongue (HP:0010808)2.01690629
67Progressive inability to walk (HP:0002505)2.00680559
68Dysdiadochokinesis (HP:0002075)2.00191479
69Cerebellar dysplasia (HP:0007033)1.99638881
70Abnormality of glycine metabolism (HP:0010895)1.98779701
71Abnormality of serine family amino acid metabolism (HP:0010894)1.98779701
72Abnormal drinking behavior (HP:0030082)1.98681380
73Polydipsia (HP:0001959)1.98681380
74Cortical dysplasia (HP:0002539)1.98017514
75Abnormality of macular pigmentation (HP:0008002)1.96948050
76Specific learning disability (HP:0001328)1.95453219
77Generalized myoclonic seizures (HP:0002123)1.92721531
78Congenital hepatic fibrosis (HP:0002612)1.91938207
79Anencephaly (HP:0002323)1.89598056
80Abnormal respiratory epithelium morphology (HP:0012253)1.88390857
81Abnormal respiratory motile cilium morphology (HP:0005938)1.88390857
82Oculomotor apraxia (HP:0000657)1.87049810
83Supernumerary spleens (HP:0009799)1.86274605
84Male pseudohermaphroditism (HP:0000037)1.86236953
85Myokymia (HP:0002411)1.86056698
86Optic nerve hypoplasia (HP:0000609)1.85673681
87Retinitis pigmentosa (HP:0000510)1.84704887
88Attenuation of retinal blood vessels (HP:0007843)1.84626073
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.83824886
90Polymicrogyria (HP:0002126)1.82071489
91Abnormal ciliary motility (HP:0012262)1.82024574
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81519785
93Bony spicule pigmentary retinopathy (HP:0007737)1.80693291
94Renal cortical cysts (HP:0000803)1.80668149
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.78933284
96Short foot (HP:0001773)1.78125570
97Acute encephalopathy (HP:0006846)1.77869502
98Poor eye contact (HP:0000817)1.76487927
99Muscular hypotonia of the trunk (HP:0008936)1.75785685
100Poor coordination (HP:0002370)1.75754933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.90713103
2WNK33.80684274
3MARK13.56167332
4MAPK133.24141719
5CDK193.19136323
6CASK2.95441201
7MAP3K42.88413251
8GRK12.59429213
9MAP2K72.38975846
10MAP4K22.38268089
11BMPR1B2.18841838
12TRIM282.07140490
13PINK12.06681450
14ADRBK22.01631476
15NUAK11.94885453
16OXSR11.94582096
17TNIK1.92711611
18AKT31.87392219
19DYRK21.83920613
20BCR1.60747394
21PNCK1.52523788
22NTRK21.47462298
23PRKCG1.35483350
24CSNK1G21.35040331
25TIE11.34995201
26MKNK21.32993659
27STK161.32811174
28INSRR1.31159939
29CSNK1G31.29172462
30CSNK1A1L1.27506050
31PRKCE1.24212912
32CSNK1G11.23732795
33ZAK1.16293636
34PLK21.15660749
35BCKDK1.15033324
36PRKD31.14928483
37MAP2K41.09589082
38PKN11.09581957
39PAK31.08132525
40CCNB11.06732003
41DAPK21.02817296
42ERBB30.96635075
43MKNK10.84938701
44SGK2230.80787353
45SGK4940.80787353
46SGK20.80407010
47DYRK1A0.78353244
48EPHA40.78136353
49WNK40.77996583
50PHKG20.77422558
51PHKG10.77422558
52STK38L0.74046929
53TLK10.72701282
54DYRK30.68107961
55SRPK10.65378225
56NTRK30.64098988
57CAMK2A0.61836064
58TXK0.58541696
59VRK10.57675295
60FGFR20.57643634
61PLK30.56961428
62PRKCZ0.56532379
63UHMK10.54686545
64PTK2B0.54446375
65CDK50.50959004
66PRKACA0.49956778
67CSNK1D0.48299490
68ADRBK10.47524193
69CSNK1A10.47083107
70FER0.46807081
71EPHA30.46636021
72CAMK2B0.46441811
73LIMK10.46170853
74TGFBR10.45304004
75TAOK30.43261997
76PRKAA10.41429706
77MAP3K60.40059148
78RPS6KA40.39922913
79TSSK60.39873264
80PRKG10.39729722
81STK380.39486566
82TNK20.38063529
83CAMK2D0.37085038
84WEE10.36897537
85MINK10.36570291
86GRK50.36569784
87CAMK40.36389083
88ACVR1B0.36297150
89MAP3K90.36286293
90DAPK10.36054611
91CAMKK20.34952137
92CDK90.34662174
93CSNK1E0.34185531
94PLK40.34085577
95STK110.31415589
96PAK60.29624881
97TAF10.28284248
98PRKCB0.27593802
99PRKCA0.26711815
100EPHB20.26514002

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.20490198
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.15445666
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95038741
4Phototransduction_Homo sapiens_hsa047442.57771910
5Butanoate metabolism_Homo sapiens_hsa006502.37359994
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33784763
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19806921
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15660613
9Propanoate metabolism_Homo sapiens_hsa006402.15449902
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.11091057
11Linoleic acid metabolism_Homo sapiens_hsa005911.96415991
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88306432
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81440400
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80849676
15Morphine addiction_Homo sapiens_hsa050321.74809630
16GABAergic synapse_Homo sapiens_hsa047271.74734067
17RNA polymerase_Homo sapiens_hsa030201.70481365
18Steroid biosynthesis_Homo sapiens_hsa001001.68739397
19Taste transduction_Homo sapiens_hsa047421.65015716
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62118850
21Selenocompound metabolism_Homo sapiens_hsa004501.60722302
22Protein export_Homo sapiens_hsa030601.57213574
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57029976
24Ether lipid metabolism_Homo sapiens_hsa005651.56915838
25beta-Alanine metabolism_Homo sapiens_hsa004101.53075820
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52128073
27Tryptophan metabolism_Homo sapiens_hsa003801.50090148
28Glutamatergic synapse_Homo sapiens_hsa047241.47319806
29Oxidative phosphorylation_Homo sapiens_hsa001901.46041630
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40514731
31Non-homologous end-joining_Homo sapiens_hsa034501.37562946
32Basal transcription factors_Homo sapiens_hsa030221.34996786
33Olfactory transduction_Homo sapiens_hsa047401.32392025
34Circadian entrainment_Homo sapiens_hsa047131.31580886
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20259998
36Caffeine metabolism_Homo sapiens_hsa002321.19407284
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18662257
38Regulation of autophagy_Homo sapiens_hsa041401.16916682
39Fanconi anemia pathway_Homo sapiens_hsa034601.16281120
40Synaptic vesicle cycle_Homo sapiens_hsa047211.15752121
41Nitrogen metabolism_Homo sapiens_hsa009101.14195730
42Retinol metabolism_Homo sapiens_hsa008301.13021091
43Homologous recombination_Homo sapiens_hsa034401.11404247
44Parkinsons disease_Homo sapiens_hsa050121.10152437
45Long-term depression_Homo sapiens_hsa047301.09115909
46Dopaminergic synapse_Homo sapiens_hsa047281.08573352
47Serotonergic synapse_Homo sapiens_hsa047261.01816883
48Collecting duct acid secretion_Homo sapiens_hsa049661.01132273
49Insulin secretion_Homo sapiens_hsa049110.99698421
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.97127223
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.96812201
52Cardiac muscle contraction_Homo sapiens_hsa042600.92550911
53Peroxisome_Homo sapiens_hsa041460.92508460
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86227196
55RNA degradation_Homo sapiens_hsa030180.83449718
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82115942
57Cocaine addiction_Homo sapiens_hsa050300.81840050
58Axon guidance_Homo sapiens_hsa043600.81184050
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78874348
60Chemical carcinogenesis_Homo sapiens_hsa052040.75944449
61Hedgehog signaling pathway_Homo sapiens_hsa043400.73582047
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.73500880
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73311734
64Fatty acid degradation_Homo sapiens_hsa000710.72706968
65Circadian rhythm_Homo sapiens_hsa047100.72480848
66Ovarian steroidogenesis_Homo sapiens_hsa049130.71138507
67Amphetamine addiction_Homo sapiens_hsa050310.70844280
68Huntingtons disease_Homo sapiens_hsa050160.68582031
69Fat digestion and absorption_Homo sapiens_hsa049750.67354820
70Glycerolipid metabolism_Homo sapiens_hsa005610.65378022
71Histidine metabolism_Homo sapiens_hsa003400.64187509
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62857824
73Purine metabolism_Homo sapiens_hsa002300.62590095
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61351167
75Salivary secretion_Homo sapiens_hsa049700.60558751
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58516037
77Metabolic pathways_Homo sapiens_hsa011000.57965182
78Calcium signaling pathway_Homo sapiens_hsa040200.55803636
79Alzheimers disease_Homo sapiens_hsa050100.54149940
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53625753
81ABC transporters_Homo sapiens_hsa020100.53257426
82Fatty acid metabolism_Homo sapiens_hsa012120.53112783
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52899573
84Arachidonic acid metabolism_Homo sapiens_hsa005900.51509958
85Pyrimidine metabolism_Homo sapiens_hsa002400.45862860
86Arginine and proline metabolism_Homo sapiens_hsa003300.45089133
87Renin-angiotensin system_Homo sapiens_hsa046140.44497040
88cAMP signaling pathway_Homo sapiens_hsa040240.43191025
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42478269
90Fatty acid biosynthesis_Homo sapiens_hsa000610.42389173
91Oxytocin signaling pathway_Homo sapiens_hsa049210.42172928
92Basal cell carcinoma_Homo sapiens_hsa052170.40493497
93Pyruvate metabolism_Homo sapiens_hsa006200.40201352
94Dorso-ventral axis formation_Homo sapiens_hsa043200.39700548
95Cholinergic synapse_Homo sapiens_hsa047250.39462659
96Fatty acid elongation_Homo sapiens_hsa000620.38922494
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38499462
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34442113
99Lysine degradation_Homo sapiens_hsa003100.34177762
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34072667

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