ZNF451

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.16397351
2replication fork processing (GO:0031297)4.15296943
3neural tube formation (GO:0001841)4.01685466
4prenylation (GO:0097354)3.91028547
5protein prenylation (GO:0018342)3.91028547
6negative regulation of DNA-dependent DNA replication (GO:2000104)3.88178496
7protein K11-linked deubiquitination (GO:0035871)3.82419249
8regulation of centriole replication (GO:0046599)3.57790110
9mitotic sister chromatid cohesion (GO:0007064)3.52878056
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.45407073
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41286681
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.41286681
13regulation of translation, ncRNA-mediated (GO:0045974)3.41286681
14regulation of DNA endoreduplication (GO:0032875)3.34025531
15resolution of meiotic recombination intermediates (GO:0000712)3.33057771
16nuclear pore complex assembly (GO:0051292)3.27202548
17monoubiquitinated protein deubiquitination (GO:0035520)3.26945481
18response to pheromone (GO:0019236)3.24202038
19microtubule anchoring (GO:0034453)3.22403552
20pyrimidine nucleobase catabolic process (GO:0006208)3.22134979
21synapsis (GO:0007129)3.15319338
22nuclear pore organization (GO:0006999)3.13346964
23regulation of centrosome duplication (GO:0010824)3.11812271
24centriole replication (GO:0007099)3.08297689
25establishment of protein localization to Golgi (GO:0072600)3.07344976
26regulation of mitotic spindle checkpoint (GO:1903504)3.04426335
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04426335
28presynaptic membrane organization (GO:0097090)3.01673887
29presynaptic membrane assembly (GO:0097105)2.96205178
30recombinational repair (GO:0000725)2.95530671
31double-strand break repair via homologous recombination (GO:0000724)2.95204045
32attachment of spindle microtubules to kinetochore (GO:0008608)2.92251391
33regulation of hexokinase activity (GO:1903299)2.91730436
34regulation of glucokinase activity (GO:0033131)2.91730436
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88089412
36histone mRNA catabolic process (GO:0071044)2.87351730
37reciprocal meiotic recombination (GO:0007131)2.85607298
38reciprocal DNA recombination (GO:0035825)2.85607298
39negative regulation of DNA recombination (GO:0045910)2.82941451
40histone H2A acetylation (GO:0043968)2.82775169
41positive regulation of developmental pigmentation (GO:0048087)2.80700040
42atrial cardiac muscle cell action potential (GO:0086014)2.76997343
43intraciliary transport (GO:0042073)2.76701583
44nucleobase catabolic process (GO:0046113)2.75410348
45protein targeting to Golgi (GO:0000042)2.75127073
46postreplication repair (GO:0006301)2.73992113
47sister chromatid cohesion (GO:0007062)2.68960623
48somatic hypermutation of immunoglobulin genes (GO:0016446)2.68136241
49somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68136241
50meiotic chromosome segregation (GO:0045132)2.68067301
51regulation of telomere maintenance (GO:0032204)2.67973104
52regulation of centrosome cycle (GO:0046605)2.67955836
53pore complex assembly (GO:0046931)2.67631853
54regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.66514154
55positive regulation of mRNA processing (GO:0050685)2.64202033
56rRNA catabolic process (GO:0016075)2.63316419
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63167978
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62447535
59regulation of nuclear cell cycle DNA replication (GO:0033262)2.62169388
60kinetochore organization (GO:0051383)2.60800684
61fucose catabolic process (GO:0019317)2.60740359
62L-fucose metabolic process (GO:0042354)2.60740359
63L-fucose catabolic process (GO:0042355)2.60740359
64photoreceptor cell maintenance (GO:0045494)2.60369713
65pyrimidine dimer repair (GO:0006290)2.56422505
66peptidyl-lysine trimethylation (GO:0018023)2.55535231
67intra-S DNA damage checkpoint (GO:0031573)2.54369400
68single strand break repair (GO:0000012)2.54094572
69double-strand break repair via nonhomologous end joining (GO:0006303)2.53855505
70non-recombinational repair (GO:0000726)2.53855505
71behavioral response to nicotine (GO:0035095)2.52817649
72regulation of pigment cell differentiation (GO:0050932)2.52504351
73microtubule organizing center organization (GO:0031023)2.51809001
74cytoplasmic mRNA processing body assembly (GO:0033962)2.51444785
75microtubule depolymerization (GO:0007019)2.49688361
76keratinocyte development (GO:0003334)2.48688532
77negative regulation of neurotransmitter transport (GO:0051589)2.48550125
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.47665757
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.47665757
80positive regulation of mitotic sister chromatid separation (GO:1901970)2.47665757
81cilium morphogenesis (GO:0060271)2.47585616
82signal peptide processing (GO:0006465)2.47563187
83retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46987453
84positive regulation of mRNA metabolic process (GO:1903313)2.46114616
85inositol phosphate catabolic process (GO:0071545)2.45151283
86centrosome organization (GO:0051297)2.43648432
87regulation of sarcomere organization (GO:0060297)2.43370255
88histone H3-K9 methylation (GO:0051567)2.41053270
89pancreas development (GO:0031016)2.39681566
90DNA replication checkpoint (GO:0000076)2.39627175
91piRNA metabolic process (GO:0034587)2.39268573
92olfactory bulb development (GO:0021772)2.39063823
93histone H3-K4 trimethylation (GO:0080182)2.38939660
94cilium organization (GO:0044782)2.38825308
95chromatin remodeling at centromere (GO:0031055)2.37252783
96phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36292861
97regulation of Rac protein signal transduction (GO:0035020)2.35366152
98histone exchange (GO:0043486)2.35010511
99cilium assembly (GO:0042384)2.34972730
100protein K6-linked ubiquitination (GO:0085020)2.34399892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.72926423
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24760564
3* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.14297005
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.88133096
5IGF1R_20145208_ChIP-Seq_DFB_Human2.86883854
6ZNF274_21170338_ChIP-Seq_K562_Hela2.86132886
7GBX2_23144817_ChIP-Seq_PC3_Human2.75316263
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71535294
9FUS_26573619_Chip-Seq_HEK293_Human2.58556544
10TAF15_26573619_Chip-Seq_HEK293_Human2.55838017
11* EWS_26573619_Chip-Seq_HEK293_Human2.50037803
12VDR_22108803_ChIP-Seq_LS180_Human2.31966010
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31903275
14P300_19829295_ChIP-Seq_ESCs_Human2.17439244
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15518116
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.09444321
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08449698
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05317698
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03110939
20E2F7_22180533_ChIP-Seq_HELA_Human1.99949832
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93537965
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89317316
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82577785
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75649876
25SMAD4_21799915_ChIP-Seq_A2780_Human1.73782209
26ER_23166858_ChIP-Seq_MCF-7_Human1.72205424
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70684399
28ELK1_19687146_ChIP-ChIP_HELA_Human1.69920615
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67790264
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67690462
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64749405
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64363600
33STAT3_23295773_ChIP-Seq_U87_Human1.63511733
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61004489
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60521627
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.58808384
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55924976
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.55481739
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54416332
40CBP_20019798_ChIP-Seq_JUKART_Human1.54416332
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.49427834
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48608039
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47871587
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.45592924
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44475460
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.43806373
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40805341
48TCF4_23295773_ChIP-Seq_U87_Human1.38864859
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37728530
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34595590
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.34396415
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33583696
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33161497
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32168897
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30773149
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30427987
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29972952
58AR_25329375_ChIP-Seq_VCAP_Human1.29619933
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28653900
60P53_22387025_ChIP-Seq_ESCs_Mouse1.28211996
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27556809
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27439243
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.27196736
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26996910
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.26815833
66BCAT_22108803_ChIP-Seq_LS180_Human1.26672800
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.26096155
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24528965
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24485120
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.23218664
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.21015395
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20960655
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20960655
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19816631
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.18968860
76IRF1_19129219_ChIP-ChIP_H3396_Human1.18619016
77RNF2_27304074_Chip-Seq_NSC_Mouse1.15493167
78RUNX2_22187159_ChIP-Seq_PCA_Human1.14217780
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13879400
80TCF4_22108803_ChIP-Seq_LS180_Human1.13870269
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.13355722
82* VDR_23849224_ChIP-Seq_CD4+_Human1.11477208
83P300_18555785_Chip-Seq_ESCs_Mouse1.10402039
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.10022151
85MYC_18940864_ChIP-ChIP_HL60_Human1.09917822
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06243522
87AR_21572438_ChIP-Seq_LNCaP_Human1.05307248
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05030310
89TP53_22573176_ChIP-Seq_HFKS_Human1.04666037
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04339593
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04247301
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03462192
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.03405093
94CDX2_22108803_ChIP-Seq_LS180_Human1.02679671
95NANOG_19829295_ChIP-Seq_ESCs_Human1.01500638
96SOX2_19829295_ChIP-Seq_ESCs_Human1.01500638
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01144714
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00300629
99SOX2_18555785_Chip-Seq_ESCs_Mouse0.99639257
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97737726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.10652496
2MP0000569_abnormal_digit_pigmentation4.05387511
3MP0008877_abnormal_DNA_methylation3.83989959
4MP0003787_abnormal_imprinting2.94372329
5MP0008058_abnormal_DNA_repair2.36007581
6MP0004147_increased_porphyrin_level2.30092147
7MP0003890_abnormal_embryonic-extraembry2.15167531
8MP0010094_abnormal_chromosome_stability2.02513922
9MP0003121_genomic_imprinting1.99521108
10MP0002102_abnormal_ear_morphology1.86632562
11MP0001984_abnormal_olfaction1.81588109
12MP0000372_irregular_coat_pigmentation1.80108599
13MP0003195_calcinosis1.74274361
14MP0006292_abnormal_olfactory_placode1.74128077
15MP0006072_abnormal_retinal_apoptosis1.73403246
16MP0005174_abnormal_tail_pigmentation1.70397452
17MP0000427_abnormal_hair_cycle1.69515332
18MP0002009_preneoplasia1.65956020
19MP0005253_abnormal_eye_physiology1.65300568
20MP0009697_abnormal_copulation1.63882882
21MP0005551_abnormal_eye_electrophysiolog1.62963026
22MP0001529_abnormal_vocalization1.62258371
23MP0000015_abnormal_ear_pigmentation1.60129566
24MP0005187_abnormal_penis_morphology1.58458608
25MP0000516_abnormal_urinary_system1.56062016
26MP0005367_renal/urinary_system_phenotyp1.56062016
27MP0002638_abnormal_pupillary_reflex1.53641595
28MP0005645_abnormal_hypothalamus_physiol1.52251806
29MP0002938_white_spotting1.51146388
30MP0003786_premature_aging1.47872098
31MP0003880_abnormal_central_pattern1.45785792
32MP0008995_early_reproductive_senescence1.45275561
33MP0003122_maternal_imprinting1.43703832
34MP0000778_abnormal_nervous_system1.43286086
35MP0002095_abnormal_skin_pigmentation1.40389131
36MP0009046_muscle_twitch1.37012062
37MP0006276_abnormal_autonomic_nervous1.35739232
38MP0002751_abnormal_autonomic_nervous1.33940582
39MP0003937_abnormal_limbs/digits/tail_de1.32041047
40MP0002837_dystrophic_cardiac_calcinosis1.31698247
41MP0000631_abnormal_neuroendocrine_gland1.25390507
42MP0004885_abnormal_endolymph1.24166707
43MP0003718_maternal_effect1.23364698
44MP0004924_abnormal_behavior1.20836538
45MP0005386_behavior/neurological_phenoty1.20836538
46MP0001929_abnormal_gametogenesis1.20656024
47MP0002234_abnormal_pharynx_morphology1.13615855
48MP0000647_abnormal_sebaceous_gland1.13522485
49MP0001188_hyperpigmentation1.13371579
50MP0006054_spinal_hemorrhage1.12903884
51MP0005646_abnormal_pituitary_gland1.12754188
52MP0002160_abnormal_reproductive_system1.10617860
53MP0001293_anophthalmia1.09612226
54MP0008007_abnormal_cellular_replicative1.09485678
55MP0001486_abnormal_startle_reflex1.09102531
56MP0003077_abnormal_cell_cycle1.04506758
57MP0010678_abnormal_skin_adnexa1.02547450
58MP0003698_abnormal_male_reproductive1.02300814
59MP0003111_abnormal_nucleus_morphology1.01570836
60MP0004142_abnormal_muscle_tone1.01162241
61MP0003943_abnormal_hepatobiliary_system1.01142527
62MP0010352_gastrointestinal_tract_polyps1.00911822
63MP0002210_abnormal_sex_determination1.00027107
64MP0005075_abnormal_melanosome_morpholog0.99236139
65MP0003567_abnormal_fetal_cardiomyocyte0.97751302
66MP0003656_abnormal_erythrocyte_physiolo0.97226171
67MP0004215_abnormal_myocardial_fiber0.96920363
68MP0005391_vision/eye_phenotype0.95362890
69MP0002928_abnormal_bile_duct0.94718579
70MP0000383_abnormal_hair_follicle0.94690813
71MP0010307_abnormal_tumor_latency0.91107962
72MP0002272_abnormal_nervous_system0.89830307
73MP0000653_abnormal_sex_gland0.89157341
74MP0005084_abnormal_gallbladder_morpholo0.88898532
75MP0010234_abnormal_vibrissa_follicle0.88758513
76MP0003119_abnormal_digestive_system0.88045181
77MP0005220_abnormal_exocrine_pancreas0.87816703
78MP0002184_abnormal_innervation0.87294538
79MP0001324_abnormal_eye_pigmentation0.86725255
80MP0001145_abnormal_male_reproductive0.84547080
81MP0005195_abnormal_posterior_eye0.84106870
82MP0008775_abnormal_heart_ventricle0.83135346
83MP0008789_abnormal_olfactory_epithelium0.82420718
84MP0009745_abnormal_behavioral_response0.82121664
85MP0004133_heterotaxia0.82004908
86MP0001485_abnormal_pinna_reflex0.81827377
87MP0002557_abnormal_social/conspecific_i0.81675536
88MP0005389_reproductive_system_phenotype0.80965524
89MP0001286_abnormal_eye_development0.79448662
90MP0010386_abnormal_urinary_bladder0.76242207
91MP0002090_abnormal_vision0.76158705
92MP0002067_abnormal_sensory_capabilities0.75399460
93MP0001968_abnormal_touch/_nociception0.75346696
94MP0009703_decreased_birth_body0.74380813
95MP0002233_abnormal_nose_morphology0.73775339
96MP0005395_other_phenotype0.73710456
97MP0003693_abnormal_embryo_hatching0.72981046
98MP0004270_analgesia0.72669724
99MP0004134_abnormal_chest_morphology0.72658527
100MP0003935_abnormal_craniofacial_develop0.71972256

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.58847244
2Chronic hepatic failure (HP:0100626)3.29663287
3Pancreatic cysts (HP:0001737)3.24859043
4Pancreatic fibrosis (HP:0100732)3.01414582
5Molar tooth sign on MRI (HP:0002419)2.96001788
6Abnormality of midbrain morphology (HP:0002418)2.96001788
7Hyperventilation (HP:0002883)2.93010774
8Nephronophthisis (HP:0000090)2.92665152
9Abnormality of chromosome stability (HP:0003220)2.85861693
10Chromsome breakage (HP:0040012)2.85455635
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81579943
12Medial flaring of the eyebrow (HP:0010747)2.76525479
13Abnormality of the renal medulla (HP:0100957)2.73067451
14True hermaphroditism (HP:0010459)2.70960557
15Abnormality of the renal cortex (HP:0011035)2.70474589
16Abnormality of the labia minora (HP:0012880)2.65470140
17Drooling (HP:0002307)2.61086217
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.58028874
19Intestinal atresia (HP:0011100)2.57738357
20Fair hair (HP:0002286)2.55075500
21Abnormality of the astrocytes (HP:0100707)2.53795160
22Astrocytoma (HP:0009592)2.53795160
23Gaze-evoked nystagmus (HP:0000640)2.44464546
24Neoplasm of the adrenal cortex (HP:0100641)2.41553631
25Glioma (HP:0009733)2.39090073
26Colon cancer (HP:0003003)2.37156951
27Protruding tongue (HP:0010808)2.35541119
28Hypothermia (HP:0002045)2.32217032
29Papillary thyroid carcinoma (HP:0002895)2.32045197
30Abnormality of the ileum (HP:0001549)2.31357844
31Excessive salivation (HP:0003781)2.31252175
32Broad-based gait (HP:0002136)2.31106676
33Aqueductal stenosis (HP:0002410)2.30734245
34Tubulointerstitial nephritis (HP:0001970)2.30534788
35Meckel diverticulum (HP:0002245)2.30107498
36Oligodactyly (hands) (HP:0001180)2.21444049
37Gait imbalance (HP:0002141)2.18989818
38Febrile seizures (HP:0002373)2.18779403
39Renal cortical cysts (HP:0000803)2.18635267
40Congenital primary aphakia (HP:0007707)2.18577016
41Thyroiditis (HP:0100646)2.15327307
42Genital tract atresia (HP:0001827)2.12327287
43Thyroid carcinoma (HP:0002890)2.11688793
44Sloping forehead (HP:0000340)2.10715807
45Submucous cleft hard palate (HP:0000176)2.08871016
46Widely spaced teeth (HP:0000687)2.06942060
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.06006010
48Ependymoma (HP:0002888)2.05190616
49Nephrogenic diabetes insipidus (HP:0009806)2.04106304
50Clubbing of toes (HP:0100760)2.02097197
51Vaginal atresia (HP:0000148)2.01461793
52Absent speech (HP:0001344)1.99074147
53Poor coordination (HP:0002370)1.97699583
54Neoplasm of the oral cavity (HP:0100649)1.96781805
55Rhabdomyosarcoma (HP:0002859)1.95871182
56Abnormality of the preputium (HP:0100587)1.95391112
57Cupped ear (HP:0000378)1.94852681
58Abnormal hair whorl (HP:0010721)1.94467143
59Progressive inability to walk (HP:0002505)1.90538052
60Aplasia/Hypoplasia of the tongue (HP:0010295)1.88731611
61Generalized hypopigmentation of hair (HP:0011358)1.86197458
62Hip dysplasia (HP:0001385)1.85170923
63Small intestinal stenosis (HP:0012848)1.83531714
64Duodenal stenosis (HP:0100867)1.83531714
65Hypoplastic iliac wings (HP:0002866)1.82223514
66Embryonal renal neoplasm (HP:0011794)1.81449169
67Postaxial foot polydactyly (HP:0001830)1.80839221
68Astigmatism (HP:0000483)1.80488275
69Abnormality of the duodenum (HP:0002246)1.79980526
70Ectopic kidney (HP:0000086)1.77120987
71Birth length less than 3rd percentile (HP:0003561)1.76555334
72Attenuation of retinal blood vessels (HP:0007843)1.75083939
73Lissencephaly (HP:0001339)1.73589387
74Small hand (HP:0200055)1.72570263
75Atonic seizures (HP:0010819)1.72368359
76Acute myeloid leukemia (HP:0004808)1.69823533
77Type II lissencephaly (HP:0007260)1.69128006
78Tubular atrophy (HP:0000092)1.68829907
79Methylmalonic acidemia (HP:0002912)1.68091039
80Dandy-Walker malformation (HP:0001305)1.67956271
81Nephroblastoma (Wilms tumor) (HP:0002667)1.67146902
82Genetic anticipation (HP:0003743)1.65380537
83Cerebellar dysplasia (HP:0007033)1.65203389
84Neoplasm of the small intestine (HP:0100833)1.64986120
85Abnormality of the metopic suture (HP:0005556)1.64240603
86Hypoplastic labia majora (HP:0000059)1.63544088
87Progressive cerebellar ataxia (HP:0002073)1.63348949
88Prominent nasal bridge (HP:0000426)1.63023146
89Abnormality of the pons (HP:0007361)1.63019459
90Thin upper lip vermilion (HP:0000219)1.62949913
91Sclerocornea (HP:0000647)1.62827808
92Highly arched eyebrow (HP:0002553)1.62743700
93Exotropia (HP:0000577)1.62275563
94Postaxial hand polydactyly (HP:0001162)1.62245145
95Duplicated collecting system (HP:0000081)1.62179289
96Preaxial hand polydactyly (HP:0001177)1.61906498
97Narrow forehead (HP:0000341)1.61650324
98Breast carcinoma (HP:0003002)1.61162329
99Abnormality of the carotid arteries (HP:0005344)1.60622214
100Cystic liver disease (HP:0006706)1.60477006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.47567518
2WNK33.14923679
3TRIM282.91546039
4MKNK22.45200506
5CASK2.40807691
6BMPR1B2.28488774
7MAP3K42.19764414
8NUAK12.18495022
9EIF2AK32.16019552
10ACVR1B2.10662571
11ERBB32.10596567
12BRSK22.09567184
13BRD42.01965842
14MAP4K21.93704020
15AKT31.84761309
16ZAK1.80306967
17BCR1.77711125
18PLK41.61875842
19MAPK131.60330765
20TNIK1.56987775
21MKNK11.54818956
22PLK21.52407401
23FGFR21.45499902
24MARK11.44299918
25WEE11.36166279
26STK391.33760470
27PLK31.25543385
28STK38L1.22967836
29BUB11.20611527
30PNCK1.10812854
31CDC71.08389903
32NLK1.06955259
33MAP2K71.06532798
34EIF2AK11.06380120
35PINK11.06115924
36PAK31.04076789
37CSNK1G11.03458603
38SRPK11.03397492
39STK31.02612921
40MST41.02304151
41OXSR11.01892090
42CAMKK21.01407258
43NTRK30.98220442
44ADRBK20.94461276
45EPHA40.94006082
46SGK20.88277260
47CSNK1A1L0.87620069
48CSNK1G20.84747205
49INSRR0.81729424
50GRK10.80751717
51TEC0.80544539
52WNK40.77187698
53VRK10.76377279
54ATM0.75437284
55CAMK1G0.75122929
56PLK10.70732692
57YES10.70257919
58CSNK1G30.69998663
59TSSK60.68921404
60TAF10.67536405
61ATR0.67431675
62TLK10.67148496
63LATS10.66326208
64SIK30.64656575
65PRKCE0.64645020
66TTK0.64260842
67FER0.63569439
68TGFBR10.63308535
69CDK30.61226414
70DYRK30.60124899
71TAOK30.59321966
72KSR10.58321087
73CHEK20.52827434
74CAMK1D0.49870394
75DYRK1A0.49724538
76CCNB10.48655546
77CSNK1D0.48271883
78TIE10.46840477
79MUSK0.46626230
80SGK2230.45010667
81SGK4940.45010667
82RPS6KA50.44790932
83NEK10.43231380
84CHEK10.43139913
85EIF2AK20.43090957
86IRAK10.41988664
87DYRK20.41506655
88PRKAA10.41449804
89TRPM70.40194636
90PIK3CG0.39938666
91PRKCG0.38832988
92RPS6KA40.38444043
93STK110.38183257
94STK240.37184836
95PIK3CA0.36890259
96PBK0.34533068
97PRKAA20.33974913
98FGFR10.32675874
99SGK30.32587807
100ADRBK10.32302309

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.44340856
2Fanconi anemia pathway_Homo sapiens_hsa034603.19574419
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91257884
4Basal transcription factors_Homo sapiens_hsa030222.71490888
5Protein export_Homo sapiens_hsa030602.68646885
6Homologous recombination_Homo sapiens_hsa034402.48483065
7Selenocompound metabolism_Homo sapiens_hsa004502.32024623
8Nicotine addiction_Homo sapiens_hsa050332.12515420
9Butanoate metabolism_Homo sapiens_hsa006502.08500480
10RNA degradation_Homo sapiens_hsa030181.99980342
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98450756
12Circadian rhythm_Homo sapiens_hsa047101.90418243
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90137343
14Phototransduction_Homo sapiens_hsa047441.84849206
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.77247577
16Propanoate metabolism_Homo sapiens_hsa006401.72974697
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68865476
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63190471
19RNA transport_Homo sapiens_hsa030131.58276974
20Nitrogen metabolism_Homo sapiens_hsa009101.56539296
21Mismatch repair_Homo sapiens_hsa034301.53747995
22Dorso-ventral axis formation_Homo sapiens_hsa043201.46706754
23Cell cycle_Homo sapiens_hsa041101.46686068
24Regulation of autophagy_Homo sapiens_hsa041401.46632846
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45381470
26Taste transduction_Homo sapiens_hsa047421.41862647
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38261655
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35953781
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34715897
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33712501
31Nucleotide excision repair_Homo sapiens_hsa034201.32858659
32Alcoholism_Homo sapiens_hsa050341.31050030
33RNA polymerase_Homo sapiens_hsa030201.30753859
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28835337
35Ether lipid metabolism_Homo sapiens_hsa005651.22638869
36Steroid biosynthesis_Homo sapiens_hsa001001.21283840
37mRNA surveillance pathway_Homo sapiens_hsa030151.19588879
38TGF-beta signaling pathway_Homo sapiens_hsa043501.19101343
39Oocyte meiosis_Homo sapiens_hsa041141.15455041
40One carbon pool by folate_Homo sapiens_hsa006701.11638295
41Lysine degradation_Homo sapiens_hsa003101.10342475
42p53 signaling pathway_Homo sapiens_hsa041151.10038580
43Systemic lupus erythematosus_Homo sapiens_hsa053221.07037097
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95216472
45Glutamatergic synapse_Homo sapiens_hsa047240.91212008
46GABAergic synapse_Homo sapiens_hsa047270.90152437
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87736219
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87520226
49Circadian entrainment_Homo sapiens_hsa047130.87473663
50ABC transporters_Homo sapiens_hsa020100.87369752
51Olfactory transduction_Homo sapiens_hsa047400.87125529
52Dopaminergic synapse_Homo sapiens_hsa047280.86280201
53Morphine addiction_Homo sapiens_hsa050320.84445560
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82034184
55Serotonergic synapse_Homo sapiens_hsa047260.79817131
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79664236
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78756483
58Long-term depression_Homo sapiens_hsa047300.77898323
59Spliceosome_Homo sapiens_hsa030400.77471039
60Insulin secretion_Homo sapiens_hsa049110.77292996
61Amphetamine addiction_Homo sapiens_hsa050310.74450037
62FoxO signaling pathway_Homo sapiens_hsa040680.71280483
63Tryptophan metabolism_Homo sapiens_hsa003800.70436233
64Purine metabolism_Homo sapiens_hsa002300.70216332
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65803489
66Peroxisome_Homo sapiens_hsa041460.64743002
67Linoleic acid metabolism_Homo sapiens_hsa005910.64421105
68DNA replication_Homo sapiens_hsa030300.63250526
69Hippo signaling pathway_Homo sapiens_hsa043900.60434158
70Hedgehog signaling pathway_Homo sapiens_hsa043400.58516691
71Inositol phosphate metabolism_Homo sapiens_hsa005620.56167874
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.55405323
73Caffeine metabolism_Homo sapiens_hsa002320.53958296
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53755404
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53703901
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51868866
77MicroRNAs in cancer_Homo sapiens_hsa052060.51141189
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49596047
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.49391064
80Melanoma_Homo sapiens_hsa052180.49372821
81Fatty acid biosynthesis_Homo sapiens_hsa000610.48726282
82Type II diabetes mellitus_Homo sapiens_hsa049300.48110638
83Colorectal cancer_Homo sapiens_hsa052100.48042818
84Sulfur metabolism_Homo sapiens_hsa009200.47574622
85Cocaine addiction_Homo sapiens_hsa050300.43132700
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43090102
87Wnt signaling pathway_Homo sapiens_hsa043100.42927378
88Fatty acid metabolism_Homo sapiens_hsa012120.42631480
89Cholinergic synapse_Homo sapiens_hsa047250.42575391
90Renin secretion_Homo sapiens_hsa049240.40363859
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38976387
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38199316
93mTOR signaling pathway_Homo sapiens_hsa041500.37919178
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37212567
95cAMP signaling pathway_Homo sapiens_hsa040240.36424740
96Axon guidance_Homo sapiens_hsa043600.36291173
97Prostate cancer_Homo sapiens_hsa052150.32956573
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.29473365
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28708822
100Calcium signaling pathway_Homo sapiens_hsa040200.27901035

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