ZNF449

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)4.32967897
2DNA double-strand break processing (GO:0000729)4.17113517
3regulation of male gonad development (GO:2000018)3.54331305
4fatty acid elongation (GO:0030497)3.49042460
5mitotic metaphase plate congression (GO:0007080)3.46925198
6regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.42481492
7metaphase plate congression (GO:0051310)3.34860471
8pyrimidine nucleobase catabolic process (GO:0006208)3.30922883
9regulation of cardioblast differentiation (GO:0051890)3.25446719
10spindle checkpoint (GO:0031577)3.13317867
11embryonic foregut morphogenesis (GO:0048617)3.11918812
12mitotic spindle checkpoint (GO:0071174)3.11904815
13regulation of acyl-CoA biosynthetic process (GO:0050812)3.08883088
14histone H2A acetylation (GO:0043968)3.07971284
15regulation of coenzyme metabolic process (GO:0051196)3.04139898
16regulation of cofactor metabolic process (GO:0051193)3.04139898
17nonmotile primary cilium assembly (GO:0035058)3.01942980
18cullin deneddylation (GO:0010388)2.97652540
19ribonucleoprotein complex disassembly (GO:0032988)2.94400235
20protein deneddylation (GO:0000338)2.94276704
21DNA integration (GO:0015074)2.93469603
22CENP-A containing nucleosome assembly (GO:0034080)2.90279232
23negative regulation of mitotic sister chromatid separation (GO:2000816)2.88214391
24negative regulation of sister chromatid segregation (GO:0033046)2.88214391
25negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88214391
26negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88214391
27negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88214391
28negative regulation of DNA recombination (GO:0045910)2.86123787
29intraciliary transport (GO:0042073)2.84222523
30mitotic spindle assembly checkpoint (GO:0007094)2.83832346
31presynaptic membrane assembly (GO:0097105)2.82604868
32olfactory bulb development (GO:0021772)2.81189145
33chromatin remodeling at centromere (GO:0031055)2.79668004
34glomerulus development (GO:0032835)2.79081035
35spindle assembly checkpoint (GO:0071173)2.78713430
36negative regulation of chromosome segregation (GO:0051985)2.75423631
37establishment of chromosome localization (GO:0051303)2.74147596
38organelle disassembly (GO:1903008)2.72169253
39positive regulation of heart growth (GO:0060421)2.71995872
40pyrimidine dimer repair (GO:0006290)2.71758675
41seminiferous tubule development (GO:0072520)2.68873895
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66265309
43cardiac muscle hypertrophy (GO:0003300)2.63507794
44cilium morphogenesis (GO:0060271)2.63373298
45male genitalia development (GO:0030539)2.62283809
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62037895
47regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62037895
48ganglion development (GO:0061548)2.61610994
49regulation of sister chromatid segregation (GO:0033045)2.60921842
50regulation of mitotic sister chromatid separation (GO:0010965)2.60921842
51regulation of mitotic sister chromatid segregation (GO:0033047)2.60921842
52cardiac muscle hypertrophy in response to stress (GO:0014898)2.60891672
53muscle hypertrophy in response to stress (GO:0003299)2.60891672
54cardiac muscle adaptation (GO:0014887)2.60891672
55microtubule depolymerization (GO:0007019)2.59133428
56positive regulation of mitochondrial fission (GO:0090141)2.58743400
57centriole replication (GO:0007099)2.57044812
58calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.56480846
59head development (GO:0060322)2.55832253
60regulation of spindle organization (GO:0090224)2.52805907
61axonal fasciculation (GO:0007413)2.51829519
62regulation of sulfur metabolic process (GO:0042762)2.49868446
63striated muscle hypertrophy (GO:0014897)2.48543503
64cellular response to gonadotropin stimulus (GO:0071371)2.47777992
65cholesterol biosynthetic process (GO:0006695)2.47685516
66regulation of mitotic spindle checkpoint (GO:1903504)2.46776126
67regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46776126
68metanephric mesenchyme development (GO:0072075)2.45515788
69regulation of DNA methylation (GO:0044030)2.45342022
70ubiquinone metabolic process (GO:0006743)2.44867875
71cardiac muscle cell development (GO:0055013)2.44357850
72establishment of integrated proviral latency (GO:0075713)2.42258282
73nucleobase catabolic process (GO:0046113)2.41816311
74cellular response to BMP stimulus (GO:0071773)2.41357624
75response to BMP (GO:0071772)2.41357624
76DNA replication-independent nucleosome organization (GO:0034724)2.41256633
77DNA replication-independent nucleosome assembly (GO:0006336)2.41256633
78regulation of female gonad development (GO:2000194)2.41220762
79neural tube formation (GO:0001841)2.40219365
80regulation of helicase activity (GO:0051095)2.39917365
81histone exchange (GO:0043486)2.39431913
82peroxisome fission (GO:0016559)2.39381722
83cerebral cortex cell migration (GO:0021795)2.37358380
84female gonad development (GO:0008585)2.37090390
85resolution of meiotic recombination intermediates (GO:0000712)2.37076800
86presynaptic membrane organization (GO:0097090)2.35851989
87positive regulation of dendritic spine morphogenesis (GO:0061003)2.34525142
88nuclear pore organization (GO:0006999)2.34197871
89regulation of chromosome segregation (GO:0051983)2.33164764
90protein localization to kinetochore (GO:0034501)2.32785013
91spermatid nucleus differentiation (GO:0007289)2.32502043
92regulation of transforming growth factor beta2 production (GO:0032909)2.32467780
93DNA ligation (GO:0006266)2.31292231
94protein localization to chromosome, centromeric region (GO:0071459)2.29865416
95sterol biosynthetic process (GO:0016126)2.29061102
96protein localization to chromosome (GO:0034502)2.29039817
97retinal ganglion cell axon guidance (GO:0031290)2.28240114
98cardiac cell development (GO:0055006)2.27853321
99ventricular cardiac muscle cell development (GO:0055015)2.27264627
100regulation of development, heterochronic (GO:0040034)2.26497678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.56447553
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.35990151
3IGF1R_20145208_ChIP-Seq_DFB_Human3.16662468
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87272662
5EZH2_22144423_ChIP-Seq_EOC_Human2.72282187
6TAF15_26573619_Chip-Seq_HEK293_Human2.57597905
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55293307
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53931895
9FUS_26573619_Chip-Seq_HEK293_Human2.36279301
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35955337
11EWS_26573619_Chip-Seq_HEK293_Human2.30460433
12ZNF274_21170338_ChIP-Seq_K562_Hela2.30416222
13ELK1_19687146_ChIP-ChIP_HELA_Human2.23243223
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.21687069
15GBX2_23144817_ChIP-Seq_PC3_Human2.21191964
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18171707
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06020046
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03437290
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88558095
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.86093319
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80970214
22P300_19829295_ChIP-Seq_ESCs_Human1.78500009
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.78408495
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73406495
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.70397353
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69348511
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63703350
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61227679
29* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61208349
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61098881
31* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57070285
32VDR_22108803_ChIP-Seq_LS180_Human1.54387896
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54155648
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53720794
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51457159
36RNF2_27304074_Chip-Seq_NSC_Mouse1.51222146
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48966102
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.47454316
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46314677
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45210169
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.44833349
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41535687
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.39068090
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37750371
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37110985
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35190762
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34284111
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32431442
49SMAD4_21799915_ChIP-Seq_A2780_Human1.32000739
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.29806481
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23507529
52VDR_23849224_ChIP-Seq_CD4+_Human1.22827530
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22714846
54CBP_20019798_ChIP-Seq_JUKART_Human1.22000084
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22000084
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21670934
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.21095300
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19489122
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17868739
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17161205
61STAT3_23295773_ChIP-Seq_U87_Human1.15285255
62IRF1_19129219_ChIP-ChIP_H3396_Human1.14805383
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13269257
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12977258
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12717335
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.12710865
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12176131
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.11670420
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.09011448
70SOX9_26525672_Chip-Seq_HEART_Mouse1.07873425
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06134065
72TCF4_23295773_ChIP-Seq_U87_Human1.04500392
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04473579
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.04222617
75MYC_18940864_ChIP-ChIP_HL60_Human1.03986807
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03974393
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03642900
78JUN_21703547_ChIP-Seq_K562_Human1.03533270
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02673547
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02142063
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02005623
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.01113136
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.00522445
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.00351425
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99986975
86RUNX2_22187159_ChIP-Seq_PCA_Human0.99330884
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98725488
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98050579
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98050579
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97132797
91TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96716618
92AR_25329375_ChIP-Seq_VCAP_Human0.95976169
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95856718
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95711213
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95677767
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95551363
97TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95458976
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.94931763
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94591445
100HTT_18923047_ChIP-ChIP_STHdh_Human0.94503334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.78540438
2MP0003890_abnormal_embryonic-extraembry2.74791911
3MP0008789_abnormal_olfactory_epithelium2.64509385
4MP0008995_early_reproductive_senescence2.55706575
5MP0005394_taste/olfaction_phenotype2.22049784
6MP0005499_abnormal_olfactory_system2.22049784
7MP0003880_abnormal_central_pattern2.11605548
8MP0006292_abnormal_olfactory_placode2.07439825
9MP0003122_maternal_imprinting2.01818661
10MP0002102_abnormal_ear_morphology2.01636344
11MP0003121_genomic_imprinting2.00984699
12MP0001293_anophthalmia1.97164015
13MP0002234_abnormal_pharynx_morphology1.94253194
14MP0009384_cardiac_valve_regurgitation1.88806939
15MP0008058_abnormal_DNA_repair1.88540405
16MP0003937_abnormal_limbs/digits/tail_de1.86502507
17MP0003567_abnormal_fetal_cardiomyocyte1.85166470
18MP0005423_abnormal_somatic_nervous1.74482714
19MP0002233_abnormal_nose_morphology1.70348401
20MP0003119_abnormal_digestive_system1.70047422
21MP0000778_abnormal_nervous_system1.69806158
22MP0006072_abnormal_retinal_apoptosis1.61842875
23MP0003221_abnormal_cardiomyocyte_apopto1.57302928
24MP0000049_abnormal_middle_ear1.53141434
25MP0000749_muscle_degeneration1.52277767
26MP0008932_abnormal_embryonic_tissue1.51909493
27MP0006276_abnormal_autonomic_nervous1.47538549
28MP0001984_abnormal_olfaction1.47140388
29MP0000516_abnormal_urinary_system1.44947798
30MP0005367_renal/urinary_system_phenotyp1.44947798
31MP0001529_abnormal_vocalization1.36503740
32MP0000751_myopathy1.33227406
33MP0004215_abnormal_myocardial_fiber1.32962981
34MP0002697_abnormal_eye_size1.32478333
35MP0003385_abnormal_body_wall1.31219099
36MP0001286_abnormal_eye_development1.30329746
37MP0004145_abnormal_muscle_electrophysio1.30215193
38MP0003718_maternal_effect1.29694569
39MP0005187_abnormal_penis_morphology1.29245538
40MP0005248_abnormal_Harderian_gland1.28913897
41MP0006054_spinal_hemorrhage1.28383621
42MP0000569_abnormal_digit_pigmentation1.25056803
43MP0000537_abnormal_urethra_morphology1.24212089
44MP0005253_abnormal_eye_physiology1.23092171
45MP0004133_heterotaxia1.21742749
46MP0003755_abnormal_palate_morphology1.18950980
47MP0003786_premature_aging1.18088100
48MP0001299_abnormal_eye_distance/1.17265402
49MP0002084_abnormal_developmental_patter1.16866934
50MP0003787_abnormal_imprinting1.14436228
51MP0000631_abnormal_neuroendocrine_gland1.14150518
52MP0003828_pulmonary_edema1.14098959
53MP0002127_abnormal_cardiovascular_syste1.13247752
54MP0003942_abnormal_urinary_system1.12324865
55MP0000639_abnormal_adrenal_gland1.12149341
56MP0004270_analgesia1.11844343
57MP0003935_abnormal_craniofacial_develop1.11841898
58MP0010030_abnormal_orbit_morphology1.08538635
59MP0000647_abnormal_sebaceous_gland1.08447910
60MP0004272_abnormal_basement_membrane1.06268390
61MP0002269_muscular_atrophy1.03883763
62MP0002090_abnormal_vision1.03477989
63MP0010368_abnormal_lymphatic_system1.02400290
64MP0005391_vision/eye_phenotype1.01499006
65MP0004085_abnormal_heartbeat1.01118411
66MP0003941_abnormal_skin_development0.99899769
67MP0003693_abnormal_embryo_hatching0.97407897
68MP0003861_abnormal_nervous_system0.96554986
69MP0004084_abnormal_cardiac_muscle0.96474022
70MP0004197_abnormal_fetal_growth/weight/0.96110123
71MP0008057_abnormal_DNA_replication0.95782661
72MP0002210_abnormal_sex_determination0.95227912
73MP0002184_abnormal_innervation0.94000854
74MP0010094_abnormal_chromosome_stability0.93798630
75MP0000428_abnormal_craniofacial_morphol0.93742886
76MP0003077_abnormal_cell_cycle0.93021926
77MP0003136_yellow_coat_color0.91998943
78MP0003315_abnormal_perineum_morphology0.91538335
79MP0004957_abnormal_blastocyst_morpholog0.91125279
80MP0000653_abnormal_sex_gland0.91089975
81MP0000358_abnormal_cell_content/0.91049352
82MP0001188_hyperpigmentation0.90764504
83MP0005380_embryogenesis_phenotype0.89178761
84MP0001672_abnormal_embryogenesis/_devel0.89178761
85MP0004811_abnormal_neuron_physiology0.88921323
86MP0001929_abnormal_gametogenesis0.88684733
87MP0002653_abnormal_ependyma_morphology0.87303183
88MP0001145_abnormal_male_reproductive0.86675787
89MP0002092_abnormal_eye_morphology0.86615880
90MP0002085_abnormal_embryonic_tissue0.86125815
91MP0002752_abnormal_somatic_nervous0.86068415
92MP0002751_abnormal_autonomic_nervous0.85658947
93MP0003137_abnormal_impulse_conducting0.85055355
94MP0008260_abnormal_autophagy0.84768423
95MP0001177_atelectasis0.83600825
96MP0009697_abnormal_copulation0.81690835
97MP0001119_abnormal_female_reproductive0.79957283
98MP0000955_abnormal_spinal_cord0.79729364
99MP0008775_abnormal_heart_ventricle0.79720822
100MP0003984_embryonic_growth_retardation0.79691581

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.88280954
2Hyperglycinemia (HP:0002154)3.80520684
3Cortical dysplasia (HP:0002539)3.49708746
4Medial flaring of the eyebrow (HP:0010747)3.33560452
5Congenital primary aphakia (HP:0007707)3.29993607
6Gait imbalance (HP:0002141)3.25877972
7Gonadal dysgenesis (HP:0000133)3.20787481
8Gonadotropin excess (HP:0000837)3.18567811
9Short tibia (HP:0005736)3.17756957
10Aplasia/Hypoplasia of the tibia (HP:0005772)3.06811566
11Exercise-induced muscle cramps (HP:0003710)2.99213947
12Nephrogenic diabetes insipidus (HP:0009806)2.93346416
13Genital tract atresia (HP:0001827)2.88780423
14Vaginal atresia (HP:0000148)2.80394586
15Abnormal lung lobation (HP:0002101)2.73933456
16Abnormality of the anterior horn cell (HP:0006802)2.62364625
17Degeneration of anterior horn cells (HP:0002398)2.62364625
18Nephroblastoma (Wilms tumor) (HP:0002667)2.60420435
19Abnormality of the lower motor neuron (HP:0002366)2.60167857
20Male pseudohermaphroditism (HP:0000037)2.59923293
21Embryonal renal neoplasm (HP:0011794)2.55398768
22Dry hair (HP:0011359)2.52412397
23Diaphragmatic weakness (HP:0009113)2.51059013
24Atrophy/Degeneration involving motor neurons (HP:0007373)2.48229048
25Hypoplastic left heart (HP:0004383)2.47889125
26Hypoplastic pelvis (HP:0008839)2.45851941
27Tubulointerstitial nephritis (HP:0001970)2.45727310
28Broad foot (HP:0001769)2.45177784
29Abnormality of the musculature of the pelvis (HP:0001469)2.43802337
30Abnormality of the hip-girdle musculature (HP:0001445)2.43802337
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.40348204
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40348204
33Papillary thyroid carcinoma (HP:0002895)2.38216119
34Bifid tongue (HP:0010297)2.37476384
35Shoulder girdle muscle weakness (HP:0003547)2.36252872
36Poor coordination (HP:0002370)2.35659998
37Colon cancer (HP:0003003)2.35235101
38Testicular neoplasm (HP:0010788)2.34129450
39Abnormality of the corticospinal tract (HP:0002492)2.33902431
40Drooling (HP:0002307)2.33214687
41Renal cortical cysts (HP:0000803)2.30810602
42Volvulus (HP:0002580)2.24091970
43Methylmalonic acidemia (HP:0002912)2.23385737
44Pancreatic fibrosis (HP:0100732)2.23030958
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.16713674
46Abnormality of glycine metabolism (HP:0010895)2.16214500
47Abnormality of serine family amino acid metabolism (HP:0010894)2.16214500
48Micropenis (HP:0000054)2.15654584
49Decreased testicular size (HP:0008734)2.11757781
50Aplasia/Hypoplasia of the lens (HP:0008063)2.08361174
51Thyroid carcinoma (HP:0002890)2.08358532
52Amyotrophic lateral sclerosis (HP:0007354)2.08324958
53Postaxial foot polydactyly (HP:0001830)2.07622994
54Absent eyebrow (HP:0002223)2.03914709
55Postaxial hand polydactyly (HP:0001162)2.03210392
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.02821233
57Excessive salivation (HP:0003781)2.02741800
58Hepatoblastoma (HP:0002884)2.00692494
59Rimmed vacuoles (HP:0003805)2.00417636
60Fibular hypoplasia (HP:0003038)1.99880468
61Abnormal biliary tract physiology (HP:0012439)1.97968291
62Bile duct proliferation (HP:0001408)1.97968291
63Adrenal hypoplasia (HP:0000835)1.97590471
64Abnormality of the labia minora (HP:0012880)1.97044559
65Oligodactyly (hands) (HP:0001180)1.95034890
66Septo-optic dysplasia (HP:0100842)1.94585775
67Aplasia/Hypoplasia of the fibula (HP:0006492)1.93140844
68Specific learning disability (HP:0001328)1.91594214
69Hypoplastic heart (HP:0001961)1.90946555
70Pancreatic cysts (HP:0001737)1.87444036
71Abnormality of midbrain morphology (HP:0002418)1.86728575
72Molar tooth sign on MRI (HP:0002419)1.86728575
73Urinary urgency (HP:0000012)1.86322749
74Ovarian neoplasm (HP:0100615)1.85547392
75Abnormal ventriculo-arterial connection (HP:0011563)1.83409521
76Transposition of the great arteries (HP:0001669)1.83409521
77Abnormal connection of the cardiac segments (HP:0011545)1.83409521
78Impaired vibration sensation in the lower limbs (HP:0002166)1.77096516
79Chronic hepatic failure (HP:0100626)1.76474179
80Preaxial foot polydactyly (HP:0001841)1.75737094
81Supernumerary spleens (HP:0009799)1.75730270
82Hand muscle atrophy (HP:0009130)1.72700091
83Curly hair (HP:0002212)1.71541807
84Occipital encephalocele (HP:0002085)1.71532675
85Abnormality of the calf musculature (HP:0001430)1.70311704
86Narrow forehead (HP:0000341)1.67776749
87Sex reversal (HP:0012245)1.67195139
88Abnormal sex determination (HP:0012244)1.67195139
89Spinal muscular atrophy (HP:0007269)1.66985504
90Left ventricular hypertrophy (HP:0001712)1.66822062
91Preaxial hand polydactyly (HP:0001177)1.65943720
92Hyperglycinuria (HP:0003108)1.65663180
93Thyroid-stimulating hormone excess (HP:0002925)1.65365159
94Vitreoretinal degeneration (HP:0000655)1.64121064
95Termporal pattern (HP:0011008)1.63245140
96Insidious onset (HP:0003587)1.63245140
97Cutaneous finger syndactyly (HP:0010554)1.63189388
98Tachypnea (HP:0002789)1.62528454
99Postnatal microcephaly (HP:0005484)1.62518979
100Oligodactyly (HP:0012165)1.62227577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK12.87072003
2TRIM282.80247102
3ERBB32.77431233
4MAP3K42.64808200
5BCR2.50235603
6NEK12.48224769
7EPHA32.38794420
8CASK2.02121522
9WNK31.99924111
10EIF2AK31.93628700
11MAP2K71.90308226
12AKT31.81875457
13PLK21.79759600
14PDK21.77367944
15OBSCN1.71285980
16PAK31.70140981
17TTK1.65601190
18PLK31.65554817
19RPS6KA41.65138158
20PLK41.63316119
21MKNK11.61706010
22BRSK21.59162056
23BRD41.54261562
24STK38L1.54117096
25EPHB21.53598040
26MKNK21.53024946
27CSNK1G21.52501111
28DYRK31.45691533
29CSNK1A1L1.41555728
30CSNK1G11.39409194
31BMPR1B1.38903600
32CSNK1G31.36819517
33ACVR1B1.36788238
34NUAK11.36452288
35MARK11.33849243
36EPHA41.27614520
37WEE11.27052194
38KSR11.24228855
39MST41.23347235
40TSSK61.17722189
41BUB11.14772622
42PLK11.13998252
43TNIK1.07723714
44ERBB41.03023324
45CDC70.96446643
46DYRK20.94869096
47MAPK130.93513002
48NEK90.92769991
49NTRK20.92764921
50PINK10.90259943
51PRKCE0.89446519
52LATS10.88604121
53PIK3CA0.84814007
54MAP2K40.82996944
55TIE10.80023523
56PBK0.78148600
57RAF10.74168431
58NEK20.72356256
59NEK60.67953506
60LIMK10.67105949
61VRK10.66596833
62FLT30.65810030
63CDK190.65601624
64MAP4K20.65390777
65FER0.65254401
66CCNB10.63630826
67STK160.62452267
68PRKCG0.61411894
69FRK0.61335831
70CAMKK20.60082648
71ATM0.59547004
72YES10.58649162
73DYRK1A0.57970710
74BRSK10.56366443
75PAK60.53372135
76ATR0.52123389
77CDK30.51581795
78TGFBR10.50605534
79STK30.50029781
80DMPK0.48986773
81FGFR10.48202169
82AURKB0.47525720
83DYRK1B0.47501174
84EIF2AK10.47396760
85CAMK2A0.46990246
86PKN10.44676311
87STK390.44410670
88PRKACB0.41578878
89PNCK0.40288848
90CHEK10.39180199
91CDK180.37987943
92MET0.37621126
93CDK140.36682476
94BRAF0.36571166
95MINK10.36277083
96CDK50.36250433
97SGK20.35743625
98ZAK0.35588924
99MAP3K50.34577544
100MYLK0.34506504

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.99423413
2Steroid biosynthesis_Homo sapiens_hsa001002.95230604
3Propanoate metabolism_Homo sapiens_hsa006402.86391059
4Basal transcription factors_Homo sapiens_hsa030222.61181749
5Non-homologous end-joining_Homo sapiens_hsa034502.55185447
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41777256
7Fatty acid elongation_Homo sapiens_hsa000622.37607354
8Protein export_Homo sapiens_hsa030602.30123521
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10048110
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90501955
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89998375
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84657857
13Fanconi anemia pathway_Homo sapiens_hsa034601.82191318
14Pyruvate metabolism_Homo sapiens_hsa006201.81575715
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77812224
16Mismatch repair_Homo sapiens_hsa034301.72285571
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70681005
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68899741
19RNA degradation_Homo sapiens_hsa030181.68394898
20Cell cycle_Homo sapiens_hsa041101.67721509
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63951946
22RNA transport_Homo sapiens_hsa030131.60332112
23Oocyte meiosis_Homo sapiens_hsa041141.48631190
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45037103
25Circadian rhythm_Homo sapiens_hsa047101.43566644
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.42135362
27Base excision repair_Homo sapiens_hsa034101.38479037
28Nucleotide excision repair_Homo sapiens_hsa034201.35854653
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34133658
30Nicotine addiction_Homo sapiens_hsa050331.28262036
31Spliceosome_Homo sapiens_hsa030401.23769465
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18132270
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17763287
34Carbon metabolism_Homo sapiens_hsa012001.17212685
35mRNA surveillance pathway_Homo sapiens_hsa030151.13350571
36Fatty acid metabolism_Homo sapiens_hsa012121.13198549
37Regulation of autophagy_Homo sapiens_hsa041401.13005475
38TGF-beta signaling pathway_Homo sapiens_hsa043501.11741196
39Hedgehog signaling pathway_Homo sapiens_hsa043401.08677881
40Peroxisome_Homo sapiens_hsa041461.05450611
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02807698
42Butanoate metabolism_Homo sapiens_hsa006501.01771049
43Axon guidance_Homo sapiens_hsa043600.98926718
44Adherens junction_Homo sapiens_hsa045200.98036838
45Hippo signaling pathway_Homo sapiens_hsa043900.96159196
46RNA polymerase_Homo sapiens_hsa030200.95943550
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95521439
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94214943
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93384726
50Basal cell carcinoma_Homo sapiens_hsa052170.89066613
51Wnt signaling pathway_Homo sapiens_hsa043100.86400554
52Huntingtons disease_Homo sapiens_hsa050160.81421050
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79659374
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78066204
55Parkinsons disease_Homo sapiens_hsa050120.77239092
56Homologous recombination_Homo sapiens_hsa034400.74938955
57p53 signaling pathway_Homo sapiens_hsa041150.74223035
58Folate biosynthesis_Homo sapiens_hsa007900.74067068
59GABAergic synapse_Homo sapiens_hsa047270.70922687
60Selenocompound metabolism_Homo sapiens_hsa004500.66304042
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65558787
62beta-Alanine metabolism_Homo sapiens_hsa004100.64217696
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63770737
64Biosynthesis of amino acids_Homo sapiens_hsa012300.63683419
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62577494
66Dilated cardiomyopathy_Homo sapiens_hsa054140.60099741
67Dopaminergic synapse_Homo sapiens_hsa047280.59505812
68Proteasome_Homo sapiens_hsa030500.59031327
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.57680307
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54166187
71Colorectal cancer_Homo sapiens_hsa052100.52932719
72Gap junction_Homo sapiens_hsa045400.50757795
73Arginine and proline metabolism_Homo sapiens_hsa003300.50096836
74Cardiac muscle contraction_Homo sapiens_hsa042600.49409480
75Tight junction_Homo sapiens_hsa045300.48616689
76Fatty acid degradation_Homo sapiens_hsa000710.45643041
77Oxidative phosphorylation_Homo sapiens_hsa001900.45384073
78Cocaine addiction_Homo sapiens_hsa050300.43617352
79Amphetamine addiction_Homo sapiens_hsa050310.41844140
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41739482
81MicroRNAs in cancer_Homo sapiens_hsa052060.41341629
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40787347
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40277005
84Metabolic pathways_Homo sapiens_hsa011000.40139588
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.37889139
86Purine metabolism_Homo sapiens_hsa002300.35335980
87Olfactory transduction_Homo sapiens_hsa047400.35192403
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34219936
89Melanoma_Homo sapiens_hsa052180.34105405
90ECM-receptor interaction_Homo sapiens_hsa045120.33512493
91Thyroid cancer_Homo sapiens_hsa052160.30865959
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28758752
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27750374
94Phototransduction_Homo sapiens_hsa047440.27745160
95Lysine degradation_Homo sapiens_hsa003100.27557502
96Glutathione metabolism_Homo sapiens_hsa004800.26559020
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26396998
98Melanogenesis_Homo sapiens_hsa049160.24860162
99AMPK signaling pathway_Homo sapiens_hsa041520.24161727
100Taste transduction_Homo sapiens_hsa047420.24094412

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