ZNF439

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose metabolic process (GO:0042354)4.46029618
2L-fucose catabolic process (GO:0042355)4.46029618
3fucose catabolic process (GO:0019317)4.46029618
4neural tube formation (GO:0001841)4.07817590
5negative regulation of mast cell activation (GO:0033004)3.99227133
6detection of light stimulus involved in sensory perception (GO:0050962)3.64961609
7detection of light stimulus involved in visual perception (GO:0050908)3.64961609
8behavioral response to nicotine (GO:0035095)3.53143101
9protein polyglutamylation (GO:0018095)3.46799815
10DNA deamination (GO:0045006)3.33901114
11protein K11-linked deubiquitination (GO:0035871)3.32473088
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30627479
13sulfation (GO:0051923)3.21437413
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.09995998
15regulation of translation, ncRNA-mediated (GO:0045974)3.09995998
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09995998
17indolalkylamine metabolic process (GO:0006586)3.09760421
18neuronal action potential (GO:0019228)3.06067156
19response to pheromone (GO:0019236)2.99051173
20negative regulation of DNA-dependent DNA replication (GO:2000104)2.95623515
21axoneme assembly (GO:0035082)2.94821357
22piRNA metabolic process (GO:0034587)2.94536470
23positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.92861876
24tryptophan catabolic process (GO:0006569)2.86389105
25indole-containing compound catabolic process (GO:0042436)2.86389105
26indolalkylamine catabolic process (GO:0046218)2.86389105
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86191269
28nonmotile primary cilium assembly (GO:0035058)2.86109889
29photoreceptor cell maintenance (GO:0045494)2.83582313
30preassembly of GPI anchor in ER membrane (GO:0016254)2.82552344
31epithelial cilium movement (GO:0003351)2.81704338
32regulation of cilium movement (GO:0003352)2.80324961
33rRNA catabolic process (GO:0016075)2.75988292
34mitochondrial respiratory chain complex I assembly (GO:0032981)2.73515635
35NADH dehydrogenase complex assembly (GO:0010257)2.73515635
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73515635
37regulation of glucokinase activity (GO:0033131)2.72748297
38regulation of hexokinase activity (GO:1903299)2.72748297
39interkinetic nuclear migration (GO:0022027)2.71246142
40tryptophan metabolic process (GO:0006568)2.68164166
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67989353
42DNA demethylation (GO:0080111)2.66884332
43cAMP catabolic process (GO:0006198)2.60068976
44cilium or flagellum-dependent cell motility (GO:0001539)2.59836633
45adenosine metabolic process (GO:0046085)2.58216778
46dentate gyrus development (GO:0021542)2.55204188
47regulation of telomere maintenance (GO:0032204)2.52913466
48pyrimidine nucleobase catabolic process (GO:0006208)2.52101295
49positive regulation of granulocyte differentiation (GO:0030854)2.51781665
50hematopoietic stem cell proliferation (GO:0071425)2.50965375
51presynaptic membrane assembly (GO:0097105)2.50311794
52gamma-aminobutyric acid transport (GO:0015812)2.46947369
53activated T cell proliferation (GO:0050798)2.46937103
54regulation of nuclear cell cycle DNA replication (GO:0033262)2.46789341
55cyclic nucleotide catabolic process (GO:0009214)2.46329718
56cilium morphogenesis (GO:0060271)2.46267371
57histone H3-K4 trimethylation (GO:0080182)2.42611227
58reciprocal meiotic recombination (GO:0007131)2.40584376
59reciprocal DNA recombination (GO:0035825)2.40584376
60positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.40540064
61regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.40540064
62presynaptic membrane organization (GO:0097090)2.40369099
63seminiferous tubule development (GO:0072520)2.40005961
64cellular ketone body metabolic process (GO:0046950)2.39574264
65positive regulation of defense response to virus by host (GO:0002230)2.39459263
66purinergic nucleotide receptor signaling pathway (GO:0035590)2.39095575
67regulation of DNA endoreduplication (GO:0032875)2.38901658
68cilium organization (GO:0044782)2.38645295
69fucosylation (GO:0036065)2.38186066
70protein complex biogenesis (GO:0070271)2.38172374
71establishment of protein localization to Golgi (GO:0072600)2.37054221
72behavioral response to ethanol (GO:0048149)2.36992563
73photoreceptor cell development (GO:0042461)2.36601113
74auditory behavior (GO:0031223)2.36099090
75serotonin receptor signaling pathway (GO:0007210)2.35828222
76monoubiquitinated protein deubiquitination (GO:0035520)2.35296035
77negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35278547
78cilium assembly (GO:0042384)2.34248803
79DNA double-strand break processing (GO:0000729)2.33631745
80mechanosensory behavior (GO:0007638)2.33054380
81mitochondrial respiratory chain complex assembly (GO:0033108)2.32975487
82platelet dense granule organization (GO:0060155)2.32278399
83mast cell activation involved in immune response (GO:0002279)2.31916319
84mast cell degranulation (GO:0043303)2.31916319
85ketone body metabolic process (GO:1902224)2.31150213
86histone H2A acetylation (GO:0043968)2.29375732
87histone H3-K9 methylation (GO:0051567)2.28968203
88cilium movement (GO:0003341)2.28037275
893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.26993444
90purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.26993444
91positive regulation of fatty acid transport (GO:2000193)2.26939388
92negative regulation of telomere maintenance (GO:0032205)2.26475508
93membrane depolarization during action potential (GO:0086010)2.25908570
94regulation of action potential (GO:0098900)2.25516356
95positive regulation of prostaglandin secretion (GO:0032308)2.24910401
96dendritic spine morphogenesis (GO:0060997)2.24598698
97centriole replication (GO:0007099)2.23976572
98somite development (GO:0061053)2.23869260
99protein-cofactor linkage (GO:0018065)2.23293959
100regulation of B cell receptor signaling pathway (GO:0050855)2.23256315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.66847132
2GBX2_23144817_ChIP-Seq_PC3_Human3.09202283
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.04410251
4IGF1R_20145208_ChIP-Seq_DFB_Human2.93160264
5VDR_22108803_ChIP-Seq_LS180_Human2.78250084
6EZH2_22144423_ChIP-Seq_EOC_Human2.77885924
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59006043
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54279654
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52470340
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.37230204
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.30982465
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12374949
13FUS_26573619_Chip-Seq_HEK293_Human2.10993825
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10779528
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.00237255
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99928801
17EWS_26573619_Chip-Seq_HEK293_Human1.98629849
18TAF15_26573619_Chip-Seq_HEK293_Human1.95457382
19P300_19829295_ChIP-Seq_ESCs_Human1.95223657
20ER_23166858_ChIP-Seq_MCF-7_Human1.91321270
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67550172
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67363201
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66777463
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62322439
25BCAT_22108803_ChIP-Seq_LS180_Human1.60725354
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58760821
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55700377
28STAT3_23295773_ChIP-Seq_U87_Human1.54636534
29CBP_20019798_ChIP-Seq_JUKART_Human1.49581605
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49581605
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49490130
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49490130
33SMAD4_21799915_ChIP-Seq_A2780_Human1.47942174
34AR_21572438_ChIP-Seq_LNCaP_Human1.46426734
35TCF4_23295773_ChIP-Seq_U87_Human1.46175426
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44658103
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44539587
38PRDM14_20953172_ChIP-Seq_ESCs_Human1.44284495
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44034959
40IRF1_19129219_ChIP-ChIP_H3396_Human1.42754207
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42193030
42AR_25329375_ChIP-Seq_VCAP_Human1.41925912
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41129245
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40605506
45TP53_22573176_ChIP-Seq_HFKS_Human1.40544336
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37026751
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.35555502
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35080087
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.34558978
50REST_21632747_ChIP-Seq_MESCs_Mouse1.34463072
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.33705543
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31245054
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31189895
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.28766282
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28056948
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26085974
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.25279229
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23874823
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21974812
60SCL_19346495_ChIP-Seq_HPC-7_Human1.21222315
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.20318397
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18532907
63NANOG_19829295_ChIP-Seq_ESCs_Human1.18286878
64SOX2_19829295_ChIP-Seq_ESCs_Human1.18286878
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17645426
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17258868
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.16678089
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16274445
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.16151317
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15811394
71* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14449077
72RUNX2_22187159_ChIP-Seq_PCA_Human1.12746271
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12725674
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11181542
75P53_22387025_ChIP-Seq_ESCs_Mouse1.11152568
76TCF4_22108803_ChIP-Seq_LS180_Human1.10982266
77RUNX_20019798_ChIP-Seq_JUKART_Human1.10953613
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10548904
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08705786
80GATA3_26560356_Chip-Seq_TH2_Human1.08150178
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08148303
82DROSHA_22980978_ChIP-Seq_HELA_Human1.07291121
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06672154
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.06672154
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.06590134
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05773363
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.04367090
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04345884
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04059558
90AR_20517297_ChIP-Seq_VCAP_Human1.00942535
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.00910037
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.99759532
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99489140
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.98070760
95RNF2_27304074_Chip-Seq_NSC_Mouse0.96955577
96MYC_18940864_ChIP-ChIP_HL60_Human0.96032743
97NCOR_22424771_ChIP-Seq_293T_Human0.95065374
98CDX2_22108803_ChIP-Seq_LS180_Human0.94394111
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.93778682
100VDR_23849224_ChIP-Seq_CD4+_Human0.93249436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.66660978
2MP0006292_abnormal_olfactory_placode3.00191732
3MP0003880_abnormal_central_pattern2.53805442
4MP0008877_abnormal_DNA_methylation2.43985869
5MP0005174_abnormal_tail_pigmentation2.34328151
6MP0005551_abnormal_eye_electrophysiolog2.14000037
7MP0003195_calcinosis2.09168336
8MP0004043_abnormal_pH_regulation2.01249306
9MP0003787_abnormal_imprinting1.98016884
10MP0002396_abnormal_hematopoietic_system1.95371419
11MP0002138_abnormal_hepatobiliary_system1.95083986
12MP0001501_abnormal_sleep_pattern1.91274353
13MP0001968_abnormal_touch/_nociception1.85102722
14MP0001986_abnormal_taste_sensitivity1.84959953
15MP0006072_abnormal_retinal_apoptosis1.84343827
16MP0004142_abnormal_muscle_tone1.79912506
17MP0000372_irregular_coat_pigmentation1.78940849
18MP0003136_yellow_coat_color1.75558657
19MP0000015_abnormal_ear_pigmentation1.71352595
20MP0006276_abnormal_autonomic_nervous1.70713522
21MP0002876_abnormal_thyroid_physiology1.64959027
22MP0002735_abnormal_chemical_nociception1.61535641
23MP0002102_abnormal_ear_morphology1.59304360
24MP0004147_increased_porphyrin_level1.59065970
25MP0008872_abnormal_physiological_respon1.58704168
26MP0005084_abnormal_gallbladder_morpholo1.57943868
27MP0009745_abnormal_behavioral_response1.56256767
28MP0002095_abnormal_skin_pigmentation1.51999710
29MP0002928_abnormal_bile_duct1.46974806
30MP0005646_abnormal_pituitary_gland1.45950346
31MP0005253_abnormal_eye_physiology1.40759960
32MP0005075_abnormal_melanosome_morpholog1.40683990
33MP0002653_abnormal_ependyma_morphology1.38485281
34MP0005645_abnormal_hypothalamus_physiol1.36398753
35MP0009046_muscle_twitch1.32989552
36MP0004885_abnormal_endolymph1.32814116
37MP0001800_abnormal_humoral_immune1.30789563
38MP0002837_dystrophic_cardiac_calcinosis1.28957181
39MP0003252_abnormal_bile_duct1.28678870
40MP0001835_abnormal_antigen_presentation1.28569562
41MP0002272_abnormal_nervous_system1.27878643
42MP0002733_abnormal_thermal_nociception1.27324814
43MP0001970_abnormal_pain_threshold1.26671757
44MP0002736_abnormal_nociception_after1.26609139
45MP0008007_abnormal_cellular_replicative1.23096603
46MP0001486_abnormal_startle_reflex1.22269900
47MP0001984_abnormal_olfaction1.22087875
48MP0005397_hematopoietic_system_phenotyp1.16208407
49MP0001545_abnormal_hematopoietic_system1.16208407
50MP0005171_absent_coat_pigmentation1.15192518
51MP0000427_abnormal_hair_cycle1.12679100
52MP0004742_abnormal_vestibular_system1.09504903
53MP0002572_abnormal_emotion/affect_behav1.07562810
54MP0010386_abnormal_urinary_bladder1.04826268
55MP0002277_abnormal_respiratory_mucosa1.02120105
56MP0000631_abnormal_neuroendocrine_gland1.01543150
57MP0008995_early_reproductive_senescence1.00897783
58MP0005220_abnormal_exocrine_pancreas1.00894794
59MP0002064_seizures1.00509596
60MP0008058_abnormal_DNA_repair1.00427951
61MP0004924_abnormal_behavior0.99067358
62MP0005386_behavior/neurological_phenoty0.99067358
63MP0003943_abnormal_hepatobiliary_system0.98041054
64MP0008875_abnormal_xenobiotic_pharmacok0.97697525
65MP0004808_abnormal_hematopoietic_stem0.97499375
66MP0004133_heterotaxia0.96303686
67MP0002822_catalepsy0.94878398
68MP0005423_abnormal_somatic_nervous0.93830882
69MP0002067_abnormal_sensory_capabilities0.92735075
70MP0003635_abnormal_synaptic_transmissio0.91898591
71MP0002163_abnormal_gland_morphology0.91619622
72MP0002557_abnormal_social/conspecific_i0.90864714
73MP0001485_abnormal_pinna_reflex0.87441934
74MP0000383_abnormal_hair_follicle0.86931564
75MP0002723_abnormal_immune_serum0.86373166
76MP0000230_abnormal_systemic_arterial0.86173811
77MP0000465_gastrointestinal_hemorrhage0.83422639
78MP0005389_reproductive_system_phenotype0.82825752
79MP0002229_neurodegeneration0.82601402
80MP0002063_abnormal_learning/memory/cond0.81239699
81MP0000685_abnormal_immune_system0.81075632
82MP0001764_abnormal_homeostasis0.81061458
83MP0002420_abnormal_adaptive_immunity0.80002507
84MP0003718_maternal_effect0.79894446
85MP0005195_abnormal_posterior_eye0.79508841
86MP0003698_abnormal_male_reproductive0.78925808
87MP0000689_abnormal_spleen_morphology0.77972259
88MP0003724_increased_susceptibility_to0.77497696
89MP0000516_abnormal_urinary_system0.77436720
90MP0005367_renal/urinary_system_phenotyp0.77436720
91MP0008961_abnormal_basal_metabolism0.77186597
92MP0001819_abnormal_immune_cell0.77000118
93MP0002452_abnormal_antigen_presenting0.75860183
94MP0004145_abnormal_muscle_electrophysio0.74546063
95MP0003763_abnormal_thymus_physiology0.74070065
96MP0005387_immune_system_phenotype0.73658661
97MP0001790_abnormal_immune_system0.73658661
98MP0005379_endocrine/exocrine_gland_phen0.72677254
99MP0003866_abnormal_defecation0.71713723
100MP0000538_abnormal_urinary_bladder0.71399765

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.46607848
2Abnormality of midbrain morphology (HP:0002418)4.18599645
3Molar tooth sign on MRI (HP:0002419)4.18599645
4Pancreatic cysts (HP:0001737)4.10579658
5True hermaphroditism (HP:0010459)3.65877381
6Pancreatic fibrosis (HP:0100732)3.49743614
7Nephronophthisis (HP:0000090)3.31676066
8Abnormality of the renal cortex (HP:0011035)3.29703624
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.27586134
10Abnormality of alanine metabolism (HP:0010916)3.27586134
11Hyperalaninemia (HP:0003348)3.27586134
12Abolished electroretinogram (ERG) (HP:0000550)3.23137584
13Abnormality of the renal medulla (HP:0100957)3.08183489
14Medial flaring of the eyebrow (HP:0010747)3.02184787
15Acute lymphatic leukemia (HP:0006721)2.99757363
16Stomach cancer (HP:0012126)2.97492643
17Abnormal rod and cone electroretinograms (HP:0008323)2.86861143
18Hyperventilation (HP:0002883)2.86663960
19Renal cortical cysts (HP:0000803)2.77515852
20Febrile seizures (HP:0002373)2.74718984
21Chronic hepatic failure (HP:0100626)2.60873833
22Type II lissencephaly (HP:0007260)2.60244165
23Cystic liver disease (HP:0006706)2.54898630
24Broad-based gait (HP:0002136)2.54748588
25Progressive cerebellar ataxia (HP:0002073)2.54641914
26Attenuation of retinal blood vessels (HP:0007843)2.54288000
27Decreased central vision (HP:0007663)2.50992828
28Genetic anticipation (HP:0003743)2.48498000
29Hemiparesis (HP:0001269)2.47152323
30Thyroiditis (HP:0100646)2.46035373
31Abnormal biliary tract physiology (HP:0012439)2.40188172
32Bile duct proliferation (HP:0001408)2.40188172
33Inability to walk (HP:0002540)2.39845909
34Abnormality of macular pigmentation (HP:0008002)2.37888010
35Absent/shortened dynein arms (HP:0200106)2.36007839
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.36007839
37Hypoplasia of the fovea (HP:0007750)2.33612422
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.33612422
39Polydipsia (HP:0001959)2.31299614
40Abnormal drinking behavior (HP:0030082)2.31299614
41Gaze-evoked nystagmus (HP:0000640)2.30220616
42Gait imbalance (HP:0002141)2.27508884
43Widely spaced teeth (HP:0000687)2.25627900
44Congenital primary aphakia (HP:0007707)2.24343192
45Panhypogammaglobulinemia (HP:0003139)2.23650490
46Large for gestational age (HP:0001520)2.23089419
47Abnormality of B cell number (HP:0010975)2.22957412
48Stomatitis (HP:0010280)2.22393274
49Congenital hepatic fibrosis (HP:0002612)2.20017598
50Progressive inability to walk (HP:0002505)2.17720935
51Albinism (HP:0001022)2.16594425
52Hypothermia (HP:0002045)2.15119422
53Neoplasm of the adrenal cortex (HP:0100641)2.14858967
54Protruding tongue (HP:0010808)2.12983380
55Nephrogenic diabetes insipidus (HP:0009806)2.12666797
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.11502994
57Fair hair (HP:0002286)2.10033165
58Severe combined immunodeficiency (HP:0004430)2.09763544
59Tubular atrophy (HP:0000092)2.07484727
60Tubulointerstitial nephritis (HP:0001970)2.04008157
61Abnormality of the fovea (HP:0000493)2.03404049
62Decreased circulating renin level (HP:0003351)2.00416423
63Focal motor seizures (HP:0011153)2.00042539
64Delayed CNS myelination (HP:0002188)1.99419214
65Abnormal delayed hypersensitivity skin test (HP:0002963)1.98949599
66Cerebellar dysplasia (HP:0007033)1.97365603
67Absent speech (HP:0001344)1.97022205
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94616991
69Severe visual impairment (HP:0001141)1.92820703
70Congenital, generalized hypertrichosis (HP:0004540)1.92440429
71Adactyly (HP:0009776)1.92053233
72Chronic sinusitis (HP:0011109)1.91546295
73Furrowed tongue (HP:0000221)1.89948876
74Elevated erythrocyte sedimentation rate (HP:0003565)1.88499739
75Generalized hypopigmentation of hair (HP:0011358)1.88443238
76Recurrent cutaneous fungal infections (HP:0011370)1.87297803
77Chronic mucocutaneous candidiasis (HP:0002728)1.87297803
78Polyuria (HP:0000103)1.85064952
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83194883
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.82317665
81Retinal dysplasia (HP:0007973)1.82127488
82Anencephaly (HP:0002323)1.81658000
83Agammaglobulinemia (HP:0004432)1.81130324
84Focal seizures (HP:0007359)1.80591201
85Central scotoma (HP:0000603)1.80172093
86Bony spicule pigmentary retinopathy (HP:0007737)1.80119849
87Abnormal ciliary motility (HP:0012262)1.78638182
88Congenital sensorineural hearing impairment (HP:0008527)1.77026575
89Sclerocornea (HP:0000647)1.76968778
90Abnormal respiratory motile cilium morphology (HP:0005938)1.76876175
91Abnormal respiratory epithelium morphology (HP:0012253)1.76876175
92Asplenia (HP:0001746)1.76622307
93Poor coordination (HP:0002370)1.75591152
94Genital tract atresia (HP:0001827)1.75530871
95Constricted visual fields (HP:0001133)1.74543257
96Vaginal atresia (HP:0000148)1.70872622
97Abnormal pancreas size (HP:0012094)1.69064696
98Macular degeneration (HP:0000608)1.68545561
99Neoplasm of the tracheobronchial system (HP:0100552)1.67472787
100Supernumerary spleens (HP:0009799)1.67443174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.68557897
2BMPR1B2.99065276
3TAOK32.79870434
4ADRBK22.70638241
5ACVR1B2.31880246
6PINK12.19460423
7MAPK132.08149780
8WNK32.00638255
9KIT1.97585690
10INSRR1.97057618
11NUAK11.96826753
12MAP4K21.86951153
13FLT31.85826811
14TXK1.74209322
15GRK11.71280869
16ZAK1.71203421
17MAP4K11.62443578
18DAPK21.58367817
19PNCK1.54059292
20TEC1.53388105
21WNK41.36626206
22CASK1.34196883
23PLK21.25460797
24SYK1.23319143
25PASK1.15898704
26ERBB31.14278305
27MARK11.10231460
28ADRBK11.07332288
29TGFBR11.06968775
30MAP3K41.05826180
31FES1.03596964
32TLK11.03536968
33MAP3K71.01891595
34CSF1R1.01883150
35CAMKK21.01678878
36PTK2B1.00188761
37ITK0.99733963
38BMPR20.97794148
39TNIK0.94911456
40CCNB10.91810842
41IKBKB0.91603168
42MAPK150.90017178
43FGFR20.88521704
44PAK30.85371901
45BRD40.84345647
46MKNK20.84075622
47PRKCQ0.81289283
48TNK20.80398569
49SIK20.78017627
50NTRK20.77773245
51PKN10.77609510
52BTK0.75066859
53DYRK20.74786340
54PRKCE0.74216289
55RIPK40.71394569
56CDK30.68900964
57IKBKE0.68718121
58LYN0.67432620
59CAMKK10.66999168
60CSNK1G20.65701097
61TRPM70.64701838
62STK110.64093761
63LCK0.63529461
64VRK10.61844972
65RPS6KA40.61701039
66CSNK1G30.60368187
67TAF10.59580433
68CSNK1G10.58361099
69TIE10.58122302
70PRKG10.54584372
71SGK20.53829521
72MKNK10.53474660
73OXSR10.53357842
74RPS6KA50.51876308
75HCK0.51411200
76CSNK1A1L0.51393894
77MAP2K60.50702239
78NLK0.49520284
79IRAK10.48034976
80GRK60.47830142
81NTRK30.47445341
82CHUK0.46277750
83MARK30.45487891
84CAMK10.45364906
85PIK3CA0.43971874
86ATR0.43096188
87PRKCI0.43059959
88BLK0.41637256
89RPS6KA60.40867038
90PRKACA0.40399476
91HIPK20.39459911
92BCKDK0.39294895
93MAP2K20.39265156
94CSNK1A10.38780977
95EPHA40.38716173
96CAMK40.38528866
97ABL10.36919200
98SGK10.36616001
99LATS10.36503401
100JAK30.36490079

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.87529612
2Phototransduction_Homo sapiens_hsa047442.38548749
3Asthma_Homo sapiens_hsa053102.32432068
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.26309398
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.21307229
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05031876
7Nitrogen metabolism_Homo sapiens_hsa009102.04464989
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.03794521
9Butanoate metabolism_Homo sapiens_hsa006501.96595802
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93216626
11Linoleic acid metabolism_Homo sapiens_hsa005911.91120722
12Primary immunodeficiency_Homo sapiens_hsa053401.89604679
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85403386
14Ether lipid metabolism_Homo sapiens_hsa005651.82696398
15Nicotine addiction_Homo sapiens_hsa050331.81998008
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81674634
17Graft-versus-host disease_Homo sapiens_hsa053321.72726130
18Type I diabetes mellitus_Homo sapiens_hsa049401.72291801
19Allograft rejection_Homo sapiens_hsa053301.68584886
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63481994
21Autoimmune thyroid disease_Homo sapiens_hsa053201.63388732
22Non-homologous end-joining_Homo sapiens_hsa034501.49109646
23Taste transduction_Homo sapiens_hsa047421.48335322
24Morphine addiction_Homo sapiens_hsa050321.41942176
25Selenocompound metabolism_Homo sapiens_hsa004501.40428893
26Circadian entrainment_Homo sapiens_hsa047131.34875173
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31799708
28Insulin secretion_Homo sapiens_hsa049111.30758825
29Homologous recombination_Homo sapiens_hsa034401.30020460
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29271865
31Regulation of autophagy_Homo sapiens_hsa041401.28718139
32Olfactory transduction_Homo sapiens_hsa047401.26230404
33Serotonergic synapse_Homo sapiens_hsa047261.22943288
34Dorso-ventral axis formation_Homo sapiens_hsa043201.18282855
35Propanoate metabolism_Homo sapiens_hsa006401.15405635
36Caffeine metabolism_Homo sapiens_hsa002321.09709417
37Tryptophan metabolism_Homo sapiens_hsa003801.09318905
38Calcium signaling pathway_Homo sapiens_hsa040201.08555693
39Hematopoietic cell lineage_Homo sapiens_hsa046401.07814762
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07565403
41Salivary secretion_Homo sapiens_hsa049701.06630680
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05011280
43Glutamatergic synapse_Homo sapiens_hsa047241.03333915
44Chemical carcinogenesis_Homo sapiens_hsa052041.01828052
45Fanconi anemia pathway_Homo sapiens_hsa034601.00616177
46Peroxisome_Homo sapiens_hsa041460.99924191
47GABAergic synapse_Homo sapiens_hsa047270.99100999
48Renin secretion_Homo sapiens_hsa049240.97605382
49Arachidonic acid metabolism_Homo sapiens_hsa005900.96694065
50RNA degradation_Homo sapiens_hsa030180.95774042
51Collecting duct acid secretion_Homo sapiens_hsa049660.94330101
52ABC transporters_Homo sapiens_hsa020100.93481609
53Basal transcription factors_Homo sapiens_hsa030220.92804027
54Long-term depression_Homo sapiens_hsa047300.92369153
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89066368
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.85483934
57Amphetamine addiction_Homo sapiens_hsa050310.84443683
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84403902
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83918715
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83511875
61Dopaminergic synapse_Homo sapiens_hsa047280.83120320
62Antigen processing and presentation_Homo sapiens_hsa046120.82313617
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.81881456
64Rheumatoid arthritis_Homo sapiens_hsa053230.81248110
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77434988
66Oxytocin signaling pathway_Homo sapiens_hsa049210.76167152
67Cholinergic synapse_Homo sapiens_hsa047250.74943768
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74671323
69Staphylococcus aureus infection_Homo sapiens_hsa051500.69400926
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69389715
71Protein export_Homo sapiens_hsa030600.68485371
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.68452922
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68060071
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.66140083
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64349677
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62356023
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60021623
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57738672
79Glycerolipid metabolism_Homo sapiens_hsa005610.57493715
80Ovarian steroidogenesis_Homo sapiens_hsa049130.57286226
81Oxidative phosphorylation_Homo sapiens_hsa001900.55733096
82Leishmaniasis_Homo sapiens_hsa051400.54894118
83cAMP signaling pathway_Homo sapiens_hsa040240.53350936
84Gastric acid secretion_Homo sapiens_hsa049710.53306428
85Cocaine addiction_Homo sapiens_hsa050300.52377629
86Pancreatic secretion_Homo sapiens_hsa049720.52338359
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50055889
88Platelet activation_Homo sapiens_hsa046110.49915732
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49217487
90Sphingolipid metabolism_Homo sapiens_hsa006000.49148424
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45921375
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44968509
93T cell receptor signaling pathway_Homo sapiens_hsa046600.44667449
94Purine metabolism_Homo sapiens_hsa002300.44604972
95Retinol metabolism_Homo sapiens_hsa008300.42423657
96beta-Alanine metabolism_Homo sapiens_hsa004100.40330415
97B cell receptor signaling pathway_Homo sapiens_hsa046620.37534093
98MAPK signaling pathway_Homo sapiens_hsa040100.37134257
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36624824
100Systemic lupus erythematosus_Homo sapiens_hsa053220.34972718

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