ZNF438

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.88868978
2response to peptidoglycan (GO:0032494)4.81693050
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.60235738
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.60235738
5modulation by symbiont of host immune response (GO:0052553)4.60235738
6positive regulation by symbiont of host defense response (GO:0052509)4.60235738
7modulation by symbiont of host defense response (GO:0052031)4.60235738
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.60235738
9neutrophil activation (GO:0042119)4.50155015
10negative regulation of interleukin-12 production (GO:0032695)4.42148601
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.41703250
12granulocyte activation (GO:0036230)4.37604842
13macrophage activation involved in immune response (GO:0002281)4.37190966
14detection of molecule of bacterial origin (GO:0032490)4.36677096
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33512637
16positive regulation of gamma-delta T cell activation (GO:0046645)4.32643431
17cellular extravasation (GO:0045123)4.23530720
18positive regulation of mast cell activation (GO:0033005)4.11860003
19leukocyte migration involved in inflammatory response (GO:0002523)3.95512382
20regulation of mast cell degranulation (GO:0043304)3.86476674
21microglial cell activation (GO:0001774)3.83179375
22immunoglobulin mediated immune response (GO:0016064)3.75403765
23negative regulation of cell killing (GO:0031342)3.69459830
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69459830
25myeloid cell activation involved in immune response (GO:0002275)3.68999871
26regulation of mast cell activation involved in immune response (GO:0033006)3.66950440
27detection of other organism (GO:0098543)3.66328810
28positive regulation of mast cell degranulation (GO:0043306)3.64657785
29positive regulation of mast cell activation involved in immune response (GO:0033008)3.64657785
30detection of external biotic stimulus (GO:0098581)3.58520584
31macrophage activation (GO:0042116)3.57839946
32regulation of mast cell activation (GO:0033003)3.52214611
33regulation of platelet activation (GO:0010543)3.40249473
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39603749
35positive regulation of toll-like receptor signaling pathway (GO:0034123)3.33056055
36regulation of platelet aggregation (GO:0090330)3.29801176
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29124931
38response to host immune response (GO:0052572)3.29124931
39regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.29015532
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26931752
41detection of bacterium (GO:0016045)3.21174228
42neutrophil mediated immunity (GO:0002446)3.20180846
43positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.19192421
44regulation of leukocyte degranulation (GO:0043300)3.17439269
45detection of biotic stimulus (GO:0009595)3.10409139
46regulation of interferon-beta biosynthetic process (GO:0045357)3.10181899
47positive regulation of cellular amide metabolic process (GO:0034250)3.09517012
48regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.08635199
49negative regulation of interleukin-17 production (GO:0032700)3.07433095
50germinal center formation (GO:0002467)3.04690615
51B cell mediated immunity (GO:0019724)3.03956047
52cellular response to thyroid hormone stimulus (GO:0097067)3.01347909
53leukocyte degranulation (GO:0043299)3.00359130
54regulation of B cell receptor signaling pathway (GO:0050855)3.00093726
55positive regulation of leukocyte degranulation (GO:0043302)2.99416415
56positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.95591239
57adenosine receptor signaling pathway (GO:0001973)2.91123199
58T-helper 1 type immune response (GO:0042088)2.90212475
59regulation of regulatory T cell differentiation (GO:0045589)2.89562167
60regulation of T-helper 2 cell differentiation (GO:0045628)2.88824929
61myeloid leukocyte activation (GO:0002274)2.87790257
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86817881
63thrombin receptor signaling pathway (GO:0070493)2.86592418
64defense response to protozoan (GO:0042832)2.85371331
65response to host defenses (GO:0052200)2.85206897
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85206897
67response to host (GO:0075136)2.85206897
68interferon-gamma-mediated signaling pathway (GO:0060333)2.84162757
69phagocytosis, engulfment (GO:0006911)2.83750495
70regulation of tolerance induction (GO:0002643)2.82746340
71regulation of gamma-delta T cell activation (GO:0046643)2.82065585
72respiratory burst (GO:0045730)2.81534252
73cellular response to type I interferon (GO:0071357)2.79628508
74type I interferon signaling pathway (GO:0060337)2.79628508
75myeloid leukocyte mediated immunity (GO:0002444)2.79415470
76glycosphingolipid catabolic process (GO:0046479)2.78805292
77regulation of T cell tolerance induction (GO:0002664)2.77506388
78response to type I interferon (GO:0034340)2.74422485
79regulation of T-helper 1 cell differentiation (GO:0045625)2.72375581
80superoxide anion generation (GO:0042554)2.71632247
81neutrophil chemotaxis (GO:0030593)2.71277093
82negative regulation of T-helper cell differentiation (GO:0045623)2.69025546
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69025546
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68626358
85positive regulation of monocyte chemotaxis (GO:0090026)2.68034357
86response to protozoan (GO:0001562)2.66335877
87positive regulation of interleukin-6 production (GO:0032755)2.65852498
88positive regulation of type 2 immune response (GO:0002830)2.64829203
89negative regulation of cytokine production involved in immune response (GO:0002719)2.64218440
90neutrophil migration (GO:1990266)2.63410399
91positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62684734
92amino sugar catabolic process (GO:0046348)2.62639010
93leukocyte aggregation (GO:0070486)2.62532784
94positive regulation of tolerance induction (GO:0002645)2.61271762
95regulation of MHC class II biosynthetic process (GO:0045346)2.60457567
96positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59435615
97regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.58251452
98production of molecular mediator involved in inflammatory response (GO:0002532)2.57103570
99regulation of mononuclear cell migration (GO:0071675)2.56241865
100G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.56133729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.91703352
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.82938203
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.66671536
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.71765196
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.59103831
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43728275
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.37188393
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.23605467
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12976744
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12331818
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11306323
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10057879
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83617819
14SCL_19346495_ChIP-Seq_HPC-7_Human2.64306628
15SPI1_23127762_ChIP-Seq_K562_Human2.55344228
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.52115273
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.51646319
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48166865
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47126819
20* SPI1_23547873_ChIP-Seq_NB4_Human2.26444676
21* VDR_24787735_ChIP-Seq_THP-1_Human2.25426335
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.20256254
23RUNX_20019798_ChIP-Seq_JUKART_Human2.11596275
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.07447003
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02938825
26LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.00769709
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99377516
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92335241
29* VDR_24763502_ChIP-Seq_THP-1_Human1.89979277
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.81864317
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77853124
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76624263
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72892008
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.71812297
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71356845
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.69976770
37* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68706381
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68236122
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66419641
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66322419
41GATA1_22025678_ChIP-Seq_K562_Human1.61195903
42MYB_26560356_Chip-Seq_TH2_Human1.59206163
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57791837
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45644593
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42738635
46GATA1_19941826_ChIP-Seq_K562_Human1.40941789
47PU_27001747_Chip-Seq_BMDM_Mouse1.39656827
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37856890
49GATA3_26560356_Chip-Seq_TH2_Human1.32783085
50GATA2_19941826_ChIP-Seq_K562_Human1.29119123
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28435075
52GATA3_27048872_Chip-Seq_THYMUS_Human1.27100970
53* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24740394
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19451714
55MYB_26560356_Chip-Seq_TH1_Human1.18160555
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13060741
57GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11804268
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11748611
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11205424
60TFEB_21752829_ChIP-Seq_HELA_Human1.10982826
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10863700
62* MAF_26560356_Chip-Seq_TH1_Human1.08643221
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.08076236
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07737306
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06522386
66VDR_21846776_ChIP-Seq_THP-1_Human1.05554675
67* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05104405
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04454336
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02394093
70UTX_26944678_Chip-Seq_JUKART_Human1.02383496
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98164948
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97812419
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95991709
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92402441
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92402441
76STAT1_20625510_ChIP-Seq_HELA_Human0.92031180
77SMRT_27268052_Chip-Seq_Bcells_Human0.90975801
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90119819
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87866234
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86743238
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86620862
82KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85032638
83STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84615537
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83629926
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83454525
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83383988
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79692188
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77368026
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75807307
90SALL4_22934838_ChIP-ChIP_CD34+_Human0.74915259
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73392368
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73244690
93SPI1_20517297_ChIP-Seq_HL60_Human0.72474250
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.71684838
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70006909
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66639356
97TCF7_22412390_ChIP-Seq_EML_Mouse0.66580509
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.63376837
99ELK4_26923725_Chip-Seq_MESODERM_Mouse0.62707297
100HTT_18923047_ChIP-ChIP_STHdh_Human0.62383385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.70242781
2MP0005464_abnormal_platelet_physiology3.98035629
3MP0003303_peritoneal_inflammation3.90394336
4MP0001835_abnormal_antigen_presentation3.36304714
5MP0003436_decreased_susceptibility_to2.97153658
6MP0005058_abnormal_lysosome_morphology2.87491380
7MP0002419_abnormal_innate_immunity2.82081260
8MP0002148_abnormal_hypersensitivity_rea2.81357896
9MP0006082_CNS_inflammation2.76299251
10MP0009785_altered_susceptibility_to2.66840003
11MP0005671_abnormal_response_to2.43940155
12MP0005000_abnormal_immune_tolerance2.43302410
13MP0008004_abnormal_stomach_pH2.40506107
14MP0005025_abnormal_response_to2.35283043
15MP0000343_altered_response_to2.34022947
16MP0003172_abnormal_lysosome_physiology2.29160603
17MP0003191_abnormal_cellular_cholesterol2.28659240
18MP0004510_myositis2.25545789
19MP0001790_abnormal_immune_system2.15181451
20MP0005387_immune_system_phenotype2.15181451
21MP0002452_abnormal_antigen_presenting2.10651005
22MP0002723_abnormal_immune_serum2.10453085
23MP0003828_pulmonary_edema2.06026006
24MP0001800_abnormal_humoral_immune2.04876524
25MP0003300_gastrointestinal_ulcer2.01578700
26MP0009764_decreased_sensitivity_to1.95185848
27MP0005167_abnormal_blood-brain_barrier1.94463695
28MP0008260_abnormal_autophagy1.93900651
29MP0005397_hematopoietic_system_phenotyp1.92309069
30MP0001545_abnormal_hematopoietic_system1.92309069
31MP0001533_abnormal_skeleton_physiology1.89984761
32MP0002420_abnormal_adaptive_immunity1.85437871
33MP0001819_abnormal_immune_cell1.83203858
34MP0000685_abnormal_immune_system1.83165181
35MP0003075_altered_response_to1.76770541
36MP0003656_abnormal_erythrocyte_physiolo1.75269238
37MP0000465_gastrointestinal_hemorrhage1.75114459
38MP0006054_spinal_hemorrhage1.75010610
39MP0009278_abnormal_bone_marrow1.70241960
40MP0009840_abnormal_foam_cell1.68569700
41MP0001845_abnormal_inflammatory_respons1.66464186
42MP0002405_respiratory_system_inflammati1.58141514
43MP0002998_abnormal_bone_remodeling1.55414311
44MP0005451_abnormal_body_composition1.50317774
45MP0010155_abnormal_intestine_physiology1.47265545
46MP0004947_skin_inflammation1.39649804
47MP0000569_abnormal_digit_pigmentation1.36579429
48MP0008469_abnormal_protein_level1.36211060
49MP0004883_abnormal_blood_vessel1.32918042
50MP0000604_amyloidosis1.32575943
51MP0000716_abnormal_immune_system1.31854533
52MP0005310_abnormal_salivary_gland1.31595091
53MP0002398_abnormal_bone_marrow1.31539686
54MP0003183_abnormal_peptide_metabolism1.30549974
55MP0005164_abnormal_response_to1.28420887
56MP0000858_altered_metastatic_potential1.27547471
57MP0002332_abnormal_exercise_endurance1.25945508
58MP0003806_abnormal_nucleotide_metabolis1.24748921
59MP0001851_eye_inflammation1.19687153
60MP0000015_abnormal_ear_pigmentation1.17689609
61MP0000689_abnormal_spleen_morphology1.16828061
62MP0005166_decreased_susceptibility_to1.11625139
63MP0003448_altered_tumor_morphology1.10017204
64MP0002429_abnormal_blood_cell1.07169813
65MP0002722_abnormal_immune_system1.05840878
66MP0003690_abnormal_glial_cell1.05731543
67MP0003646_muscle_fatigue1.05508230
68MP0009333_abnormal_splenocyte_physiolog1.05021815
69MP0009763_increased_sensitivity_to1.00400028
70MP0000249_abnormal_blood_vessel1.00215822
71MP0001853_heart_inflammation0.99089115
72MP0004130_abnormal_muscle_cell0.91307045
73MP0004808_abnormal_hematopoietic_stem0.87136072
74MP0005174_abnormal_tail_pigmentation0.83135321
75MP0008874_decreased_physiological_sensi0.82388192
76MP0002132_abnormal_respiratory_system0.81449052
77MP0001542_abnormal_bone_strength0.80327036
78MP0009765_abnormal_xenobiotic_induced0.78549701
79MP0004484_altered_response_of0.78102280
80MP0003795_abnormal_bone_structure0.76864289
81MP0002277_abnormal_respiratory_mucosa0.76097214
82MP0003453_abnormal_keratinocyte_physiol0.75298951
83MP0005390_skeleton_phenotype0.73120900
84MP0001663_abnormal_digestive_system0.70680565
85MP0004036_abnormal_muscle_relaxation0.70618121
86MP0003763_abnormal_thymus_physiology0.70101716
87MP0005165_increased_susceptibility_to0.69311307
88MP0003091_abnormal_cell_migration0.69131488
89MP0000920_abnormal_myelination0.66719099
90MP0005647_abnormal_sex_gland0.65170804
91MP0003045_fibrosis0.61562659
92MP0002139_abnormal_hepatobiliary_system0.60657631
93MP0005410_abnormal_fertilization0.60312710
94MP0000230_abnormal_systemic_arterial0.59450017
95MP0003221_abnormal_cardiomyocyte_apopto0.59082959
96MP0002972_abnormal_cardiac_muscle0.58825683
97MP0000703_abnormal_thymus_morphology0.58313899
98MP0005376_homeostasis/metabolism_phenot0.57452032
99MP0005319_abnormal_enzyme/_coenzyme0.57159404
100MP0004084_abnormal_cardiac_muscle0.57154838

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)5.33952864
2Abnormality of liposaccharide metabolism (HP:0010968)5.26803740
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.26803740
4Abnormality of glycolipid metabolism (HP:0010969)5.26803740
5Recurrent abscess formation (HP:0002722)5.13522489
6Recurrent bacterial skin infections (HP:0005406)5.01939625
7Prolonged bleeding time (HP:0003010)4.90536114
8Eczematoid dermatitis (HP:0000976)4.86811556
9Petechiae (HP:0000967)4.66475376
10Stomatitis (HP:0010280)4.34289870
11Purpura (HP:0000979)4.29768055
12Epistaxis (HP:0000421)3.95177621
13Gingival bleeding (HP:0000225)3.86858988
14Recurrent gram-negative bacterial infections (HP:0005420)3.86078056
15Spontaneous hematomas (HP:0007420)3.78379736
16Orchitis (HP:0100796)3.72072153
17Myositis (HP:0100614)3.67790934
18Retrobulbar optic neuritis (HP:0100654)3.63620704
19Optic neuritis (HP:0100653)3.63620704
20Vacuolated lymphocytes (HP:0001922)3.55643375
21Abnormal platelet volume (HP:0011876)3.55476684
22Increased cerebral lipofuscin (HP:0011813)3.54495165
23Obstructive lung disease (HP:0006536)3.38259902
24Chronic obstructive pulmonary disease (HP:0006510)3.38259902
25Disinhibition (HP:0000734)3.31626692
26Increased mean platelet volume (HP:0011877)3.31103283
27Menorrhagia (HP:0000132)3.25735608
28Dysostosis multiplex (HP:0000943)3.20962500
29Abnormality of the vasculature of the conjunctiva (HP:0008054)3.19366209
30Loss of speech (HP:0002371)3.11696106
31Recurrent skin infections (HP:0001581)2.97907552
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.90799985
33Mediastinal lymphadenopathy (HP:0100721)2.90145384
34Systemic lupus erythematosus (HP:0002725)2.89356942
35Conjunctival telangiectasia (HP:0000524)2.80822906
36Elevated erythrocyte sedimentation rate (HP:0003565)2.79194657
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.75630290
38Hepatosplenomegaly (HP:0001433)2.72926455
39Recurrent fungal infections (HP:0002841)2.70908824
40Gingivitis (HP:0000230)2.70792336
41Amyloidosis (HP:0011034)2.61702473
42Increased IgM level (HP:0003496)2.61470530
43Keratoconjunctivitis sicca (HP:0001097)2.58532381
44Arterial thrombosis (HP:0004420)2.57980042
45Chest pain (HP:0100749)2.55393557
46Encephalitis (HP:0002383)2.52734707
47Impaired platelet aggregation (HP:0003540)2.51505820
48Abnormal platelet function (HP:0011869)2.51505820
49Myocardial infarction (HP:0001658)2.51473013
50Episodic fever (HP:0001954)2.50997561
51Autoimmune thrombocytopenia (HP:0001973)2.46835482
52Meningitis (HP:0001287)2.41280769
53Urticaria (HP:0001025)2.35788548
54Keratoconjunctivitis (HP:0001096)2.34524026
55Recurrent cutaneous fungal infections (HP:0011370)2.32676372
56Chronic mucocutaneous candidiasis (HP:0002728)2.32676372
57Abnormality of polysaccharide metabolism (HP:0011012)2.31962749
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31962749
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31962749
60Vasculitis (HP:0002633)2.29978613
61Hematochezia (HP:0002573)2.27383492
62Pulmonary infiltrates (HP:0002113)2.25928865
63Increased serum ferritin (HP:0003281)2.25196103
64Abnormality of iron homeostasis (HP:0011031)2.25147419
65Hemoptysis (HP:0002105)2.23130834
66Leukocytosis (HP:0001974)2.20980073
67Hyperlipoproteinemia (HP:0010980)2.20510089
68Gastrointestinal infarctions (HP:0005244)2.19273284
69Axonal loss (HP:0003447)2.18741721
70T lymphocytopenia (HP:0005403)2.16345995
71Abnormality of lateral ventricle (HP:0030047)2.13745779
72Upper motor neuron abnormality (HP:0002127)2.11221718
73Dyschromatopsia (HP:0007641)2.10562907
74Muscle fiber splitting (HP:0003555)2.09928155
75Urinary glycosaminoglycan excretion (HP:0003541)2.09339377
76Mucopolysacchariduria (HP:0008155)2.09339377
77Polyneuropathy (HP:0001271)2.08065254
78Abnormality of T cell number (HP:0011839)2.07336621
79Mutism (HP:0002300)2.05295199
80Polycythemia (HP:0001901)2.05243844
81Pulmonary embolism (HP:0002204)2.04379611
82Vertigo (HP:0002321)1.99216195
83Abnormal delayed hypersensitivity skin test (HP:0002963)1.98973435
84Basal ganglia calcification (HP:0002135)1.95174500
85Progressive neurologic deterioration (HP:0002344)1.92228518
86Inflammation of the large intestine (HP:0002037)1.91945046
87Gangrene (HP:0100758)1.91354658
88Joint swelling (HP:0001386)1.90757238
89Recurrent viral infections (HP:0004429)1.89624380
90Paralysis (HP:0003470)1.89482684
91Abnormality of transition element cation homeostasis (HP:0011030)1.86963939
92Osteomyelitis (HP:0002754)1.85256349
93Bruising susceptibility (HP:0000978)1.83509585
94Hypergammaglobulinemia (HP:0010702)1.83023966
95Agnosia (HP:0010524)1.82115022
96Mucosal telangiectasiae (HP:0100579)1.79789156
97Asymmetric septal hypertrophy (HP:0001670)1.77667208
98Nausea (HP:0002018)1.76835333
99Granulocytopenia (HP:0001913)1.76110640
100Abnormality of the prostate (HP:0008775)1.75043823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.58986514
2BLK3.28532671
3MAP2K32.94441827
4FGR2.70050350
5IRAK32.47933307
6CSK2.38894757
7TYK22.35039585
8IRAK42.34307634
9ZAP702.30434080
10ACVR1B2.12578325
11CSF1R2.05657656
12BTK1.98097823
13MAP3K141.97926824
14MAP4K11.89511894
15FES1.84047837
16SYK1.81687060
17TXK1.80286229
18PTK2B1.80186906
19TGFBR21.79509999
20GRK71.77773582
21TNK21.77063623
22EPHB11.73645262
23BMX1.69452973
24PIK3CG1.66798920
25TAOK31.65700819
26HCK1.57777560
27MATK1.53843611
28JAK31.50754071
29LYN1.50517189
30TBK11.48712275
31TEC1.48183186
32MARK31.46534179
33BMPR21.45259600
34TAOK11.42725262
35IKBKE1.34180412
36IKBKB1.29697957
37IRAK11.21818197
38YES11.20423499
39MAP3K51.19001872
40MAP3K31.17736941
41JAK21.17588308
42TAOK21.15966704
43MAP3K11.15057388
44MAP3K111.07831520
45KIT1.03956538
46JAK11.03091726
47OBSCN1.02915068
48EPHA31.01822538
49MYLK0.99846570
50CAMKK20.98621401
51ERN10.94804939
52GRK60.94275171
53MAP3K60.94121514
54LCK0.93584553
55ADRBK20.92268947
56IRAK20.90918915
57MAP2K60.88309676
58MOS0.79886010
59SIK30.75312358
60NEK90.73648877
61PDK10.72894342
62GRK50.71731425
63DDR20.69236364
64CDC42BPA0.62431168
65MST40.61857509
66ITK0.60868217
67FRK0.59050487
68PDPK10.57987079
69MAPK120.56666624
70STK30.55476918
71KSR10.54606334
72MAP2K40.54396013
73MAP3K130.53672668
74PDGFRB0.52756849
75RET0.50676394
76FYN0.50401346
77PRPF4B0.48279453
78DAPK20.45816756
79SGK30.45179380
80DYRK30.42833541
81MARK20.42503531
82ABL10.42457014
83PRKD10.42251582
84MAP3K20.39102815
85TTN0.37130479
86ABL20.36918568
87PKN10.35459137
88PRKCQ0.35119714
89FER0.34889101
90SGK20.34709926
91STK100.33617180
92KSR20.33615535
93STK240.32365993
94PIM20.31987272
95PLK20.30550015
96DYRK1B0.29953178
97GSK3A0.29589290
98FGFR30.28409662
99EGFR0.28305923
100PRKG10.28243401

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.94739629
2Staphylococcus aureus infection_Homo sapiens_hsa051502.85575461
3Leishmaniasis_Homo sapiens_hsa051402.63959975
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45144068
5Lysosome_Homo sapiens_hsa041422.29119200
6Tuberculosis_Homo sapiens_hsa051522.21142876
7Malaria_Homo sapiens_hsa051442.15343096
8Other glycan degradation_Homo sapiens_hsa005112.09983872
9Platelet activation_Homo sapiens_hsa046112.00912667
10Rheumatoid arthritis_Homo sapiens_hsa053231.95723699
11Allograft rejection_Homo sapiens_hsa053301.94626400
12Phagosome_Homo sapiens_hsa041451.92673706
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88427392
14Legionellosis_Homo sapiens_hsa051341.84089368
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.81381227
16Graft-versus-host disease_Homo sapiens_hsa053321.77724824
17Hematopoietic cell lineage_Homo sapiens_hsa046401.73238213
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67240061
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.65942915
20Chemokine signaling pathway_Homo sapiens_hsa040621.65420599
21Autoimmune thyroid disease_Homo sapiens_hsa053201.64951139
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63682443
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63409013
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57118564
25Pertussis_Homo sapiens_hsa051331.53234277
26B cell receptor signaling pathway_Homo sapiens_hsa046621.52172859
27Asthma_Homo sapiens_hsa053101.50958217
28Salmonella infection_Homo sapiens_hsa051321.50710303
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47682517
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47128284
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44920937
32TNF signaling pathway_Homo sapiens_hsa046681.43402296
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36052530
34Toxoplasmosis_Homo sapiens_hsa051451.31849241
35Shigellosis_Homo sapiens_hsa051311.31206420
36Type I diabetes mellitus_Homo sapiens_hsa049401.30730350
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29810433
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29257804
39Collecting duct acid secretion_Homo sapiens_hsa049661.29093462
40Influenza A_Homo sapiens_hsa051641.28949335
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27439150
42Measles_Homo sapiens_hsa051621.23287121
43Viral myocarditis_Homo sapiens_hsa054161.23211280
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21041778
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20390083
46African trypanosomiasis_Homo sapiens_hsa051431.18969029
47Antigen processing and presentation_Homo sapiens_hsa046121.14291149
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12805580
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.11091795
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.10028556
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.09412085
52Herpes simplex infection_Homo sapiens_hsa051680.97737681
53T cell receptor signaling pathway_Homo sapiens_hsa046600.94021210
54Acute myeloid leukemia_Homo sapiens_hsa052210.86807087
55Hepatitis C_Homo sapiens_hsa051600.84406424
56Amoebiasis_Homo sapiens_hsa051460.84145400
57Hepatitis B_Homo sapiens_hsa051610.81593537
58Apoptosis_Homo sapiens_hsa042100.81180696
59Primary immunodeficiency_Homo sapiens_hsa053400.77872959
60Endocytosis_Homo sapiens_hsa041440.77073272
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76988949
62Complement and coagulation cascades_Homo sapiens_hsa046100.73902645
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70517988
64Regulation of autophagy_Homo sapiens_hsa041400.69409899
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68324249
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66560890
67VEGF signaling pathway_Homo sapiens_hsa043700.65872089
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.65504936
69Pancreatic cancer_Homo sapiens_hsa052120.64907916
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.64880709
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63810074
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58177981
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54614711
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.53762741
75Renal cell carcinoma_Homo sapiens_hsa052110.53647131
76Sphingolipid metabolism_Homo sapiens_hsa006000.53027899
77Prolactin signaling pathway_Homo sapiens_hsa049170.52819530
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.52690136
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51980001
80Non-small cell lung cancer_Homo sapiens_hsa052230.51008903
81HIF-1 signaling pathway_Homo sapiens_hsa040660.46317548
82Dorso-ventral axis formation_Homo sapiens_hsa043200.46249656
83Arachidonic acid metabolism_Homo sapiens_hsa005900.45925460
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44642757
85PPAR signaling pathway_Homo sapiens_hsa033200.42802931
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42092474
87GnRH signaling pathway_Homo sapiens_hsa049120.39405568
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39355049
89FoxO signaling pathway_Homo sapiens_hsa040680.36811390
90Viral carcinogenesis_Homo sapiens_hsa052030.34264739
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32679269
92Chronic myeloid leukemia_Homo sapiens_hsa052200.32275466
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.30626466
94Galactose metabolism_Homo sapiens_hsa000520.30384450
95Rap1 signaling pathway_Homo sapiens_hsa040150.29232735
96Insulin resistance_Homo sapiens_hsa049310.28412348
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27975375
98Fatty acid elongation_Homo sapiens_hsa000620.27720788
99Type II diabetes mellitus_Homo sapiens_hsa049300.26731253
100Gap junction_Homo sapiens_hsa045400.26725466

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