ZNF436

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.07736144
2regulation of cAMP-dependent protein kinase activity (GO:2000479)4.03565415
3presynaptic membrane assembly (GO:0097105)3.72671940
4axonal fasciculation (GO:0007413)3.48154137
5presynaptic membrane organization (GO:0097090)3.19790352
6neuron recognition (GO:0008038)3.16991351
7postsynaptic membrane organization (GO:0001941)3.09879521
8retina vasculature morphogenesis in camera-type eye (GO:0061299)3.08395937
9nucleobase catabolic process (GO:0046113)3.01283694
10cardiac myofibril assembly (GO:0055003)2.98043830
11negative regulation of protein localization to cell surface (GO:2000009)2.95500409
12neuron cell-cell adhesion (GO:0007158)2.93955124
13regulation of sarcomere organization (GO:0060297)2.84226190
14cerebral cortex radially oriented cell migration (GO:0021799)2.82387831
15calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.81525743
16negative regulation of oligodendrocyte differentiation (GO:0048715)2.81036052
17membrane assembly (GO:0071709)2.75246513
18layer formation in cerebral cortex (GO:0021819)2.71742455
19dendrite morphogenesis (GO:0048813)2.70157161
20regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63414986
21Notch signaling involved in heart development (GO:0061314)2.57799518
22endocardial cushion morphogenesis (GO:0003203)2.53078019
23C4-dicarboxylate transport (GO:0015740)2.51888578
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.51582259
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50280410
26myofibril assembly (GO:0030239)2.47728872
27vocalization behavior (GO:0071625)2.47248709
28peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44037046
29positive regulation of muscle hypertrophy (GO:0014742)2.41907716
30positive regulation of cardiac muscle hypertrophy (GO:0010613)2.41907716
31carnitine shuttle (GO:0006853)2.38090932
32central nervous system projection neuron axonogenesis (GO:0021952)2.37612769
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35339774
34cardiac chamber formation (GO:0003207)2.32119661
35synapse assembly (GO:0007416)2.31685309
36regulation of axon extension involved in axon guidance (GO:0048841)2.31014446
37positive regulation of synapse assembly (GO:0051965)2.30829765
38ionotropic glutamate receptor signaling pathway (GO:0035235)2.30284517
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.29723198
40auditory behavior (GO:0031223)2.28581141
41cardiac ventricle formation (GO:0003211)2.26399146
42collagen fibril organization (GO:0030199)2.26106533
43dermatan sulfate biosynthetic process (GO:0030208)2.26049635
44regulation of transforming growth factor beta2 production (GO:0032909)2.25430582
45gamma-aminobutyric acid transport (GO:0015812)2.23970103
46mesenchyme morphogenesis (GO:0072132)2.23929093
47myotube differentiation (GO:0014902)2.22601379
48cerebral cortex cell migration (GO:0021795)2.21758618
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.21528575
50regulation of cardiac muscle hypertrophy (GO:0010611)2.20577300
51regulation of synapse assembly (GO:0051963)2.18804217
52axon extension (GO:0048675)2.18264982
53regulation of muscle hypertrophy (GO:0014743)2.16243866
54lens morphogenesis in camera-type eye (GO:0002089)2.16164583
55morphogenesis of an epithelial sheet (GO:0002011)2.15846637
56regulation of relaxation of muscle (GO:1901077)2.14882184
57apical protein localization (GO:0045176)2.14557996
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.14167049
59head development (GO:0060322)2.13761292
60cell communication by electrical coupling (GO:0010644)2.12905579
61regulation of axon guidance (GO:1902667)2.12313136
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.11456661
63limb bud formation (GO:0060174)2.11339493
64establishment of nucleus localization (GO:0040023)2.10226660
65mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.09771955
66nucleus localization (GO:0051647)2.09154659
67regulation of skeletal muscle cell differentiation (GO:2001014)2.08476198
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.08274310
69heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.08161080
70astrocyte development (GO:0014002)2.08069937
71L-serine transport (GO:0015825)2.07967477
72establishment of mitochondrion localization (GO:0051654)2.07840379
73protein localization to synapse (GO:0035418)2.07652564
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.07412448
75ephrin receptor signaling pathway (GO:0048013)2.07384833
76regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.07072991
77negative regulation of neurotransmitter secretion (GO:0046929)2.06427216
78synapse organization (GO:0050808)2.05706205
79myoblast fusion (GO:0007520)2.05621423
80heart valve morphogenesis (GO:0003179)2.05222526
81peripheral nervous system axon ensheathment (GO:0032292)2.04408858
82myelination in peripheral nervous system (GO:0022011)2.04408858
83regulation of cardiac muscle cell differentiation (GO:2000725)2.04300995
84dermatan sulfate metabolic process (GO:0030205)2.04299012
85extracellular fibril organization (GO:0043206)2.02710917
86homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.02691442
87positive regulation of potassium ion transport (GO:0043268)2.02519344
88regulation of synaptic vesicle exocytosis (GO:2000300)2.02247987
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.02152517
90regulation of glycogen (starch) synthase activity (GO:2000465)2.01448907
91neurotransmitter-gated ion channel clustering (GO:0072578)2.00555006
92negative regulation of potassium ion transmembrane transport (GO:1901380)2.00412173
93response to auditory stimulus (GO:0010996)2.00300382
94nerve growth factor signaling pathway (GO:0038180)2.00088518
95cellular response to catecholamine stimulus (GO:0071870)1.99978821
96cellular response to monoamine stimulus (GO:0071868)1.99978821
97fatty acid transmembrane transport (GO:1902001)1.99906651
98heart valve formation (GO:0003188)1.98832179
99fatty acid elongation (GO:0030497)1.98739455
100asymmetric protein localization (GO:0008105)1.98722751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.80663096
2GBX2_23144817_ChIP-Seq_PC3_Human3.19723049
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.77646715
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.69995474
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50653752
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.46200725
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39665233
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30442519
9PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.25523039
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25014576
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11790667
12PIAS1_25552417_ChIP-Seq_VCAP_Human2.00396861
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91976685
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.89964389
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.89715502
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89405932
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.86615701
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85692789
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85113973
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.84151004
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81333651
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78968713
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.77806823
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74191186
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72620712
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71643313
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71338229
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71016305
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71016305
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67205047
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67205047
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67001662
33SMAD4_21799915_ChIP-Seq_A2780_Human1.66799935
34IGF1R_20145208_ChIP-Seq_DFB_Human1.66544939
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64481184
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63858049
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61586352
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60944366
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59979100
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59421021
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.57997590
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54111179
43TAF15_26573619_Chip-Seq_HEK293_Human1.52161255
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49271214
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48531243
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.47324627
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44284874
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43650430
49TP53_16413492_ChIP-PET_HCT116_Human1.40289263
50CJUN_26792858_Chip-Seq_BT549_Human1.38261047
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36335092
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35632667
53STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34529506
54RNF2_27304074_Chip-Seq_NSC_Mouse1.33224735
55FUS_26573619_Chip-Seq_HEK293_Human1.33139321
56TP53_18474530_ChIP-ChIP_U2OS_Human1.32583157
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31827710
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30647498
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30281331
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30265263
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29907034
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.29606840
63YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27599935
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27300734
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.26177545
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25528218
67LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25162783
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25081269
69STAT3_23295773_ChIP-Seq_U87_Human1.24798273
70P300_19829295_ChIP-Seq_ESCs_Human1.23320662
71AHR_22903824_ChIP-Seq_MCF-7_Human1.22770286
72AR_21572438_ChIP-Seq_LNCaP_Human1.22306986
73ZNF274_21170338_ChIP-Seq_K562_Hela1.21332944
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17842457
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17649294
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.16865604
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16504034
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15874342
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.14650246
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.12093959
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12090240
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11292603
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.10642202
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10146730
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10117405
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.09032047
87EWS_26573619_Chip-Seq_HEK293_Human1.08359438
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07612472
89KDM2B_26808549_Chip-Seq_REH_Human1.06908555
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.03926641
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.03297349
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00673140
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99594949
94AR_25329375_ChIP-Seq_VCAP_Human0.99463132
95TCF4_23295773_ChIP-Seq_U87_Human0.99403771
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98666833
97* AR_19668381_ChIP-Seq_PC3_Human0.97917175
98CBP_20019798_ChIP-Seq_JUKART_Human0.97904070
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97904070
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.97359259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.42103796
2MP0005275_abnormal_skin_tensile3.14070385
3MP0004270_analgesia2.72667007
4MP0000751_myopathy2.56482369
5MP0004272_abnormal_basement_membrane2.47212092
6MP0004859_abnormal_synaptic_plasticity2.37947297
7MP0010368_abnormal_lymphatic_system2.36703584
8MP0005503_abnormal_tendon_morphology2.28789343
9MP0005248_abnormal_Harderian_gland2.16055589
10MP0000778_abnormal_nervous_system2.00535618
11MP0001879_abnormal_lymphatic_vessel1.99129635
12MP0000537_abnormal_urethra_morphology1.85778908
13MP0005187_abnormal_penis_morphology1.78013587
14MP0010386_abnormal_urinary_bladder1.74038483
15MP0004145_abnormal_muscle_electrophysio1.57926968
16MP0000462_abnormal_digestive_system1.57758799
17MP0005367_renal/urinary_system_phenotyp1.52981175
18MP0000516_abnormal_urinary_system1.52981175
19MP0003705_abnormal_hypodermis_morpholog1.48664058
20MP0002108_abnormal_muscle_morphology1.47627792
21MP0002822_catalepsy1.45810686
22MP0001984_abnormal_olfaction1.45712433
23MP0000749_muscle_degeneration1.44435465
24MP0002734_abnormal_mechanical_nocicepti1.42159334
25MP0000534_abnormal_ureter_morphology1.41508161
26MP0001270_distended_abdomen1.40728917
27MP0001958_emphysema1.39635934
28MP0004885_abnormal_endolymph1.36947176
29MP0004084_abnormal_cardiac_muscle1.34861845
30MP0001299_abnormal_eye_distance/1.34205712
31MP0002735_abnormal_chemical_nociception1.32797652
32MP0002638_abnormal_pupillary_reflex1.32677274
33MP0000013_abnormal_adipose_tissue1.32055463
34MP0003635_abnormal_synaptic_transmissio1.28490595
35MP0002233_abnormal_nose_morphology1.28271284
36MP0003385_abnormal_body_wall1.26856681
37MP0002234_abnormal_pharynx_morphology1.23671594
38MP0003880_abnormal_central_pattern1.23023332
39MP0001502_abnormal_circadian_rhythm1.21847564
40MP0002896_abnormal_bone_mineralization1.19173314
41MP0005623_abnormal_meninges_morphology1.17864770
42MP0001177_atelectasis1.17745507
43MP0003935_abnormal_craniofacial_develop1.15890036
44MP0003279_aneurysm1.15861776
45MP0004233_abnormal_muscle_weight1.14894010
46MP0009384_cardiac_valve_regurgitation1.11874984
47MP0003122_maternal_imprinting1.11811447
48MP0004215_abnormal_myocardial_fiber1.10951366
49MP0003755_abnormal_palate_morphology1.10747303
50MP0003300_gastrointestinal_ulcer1.10634849
51MP0000762_abnormal_tongue_morphology1.10170860
52MP0003941_abnormal_skin_development1.10146970
53MP0000383_abnormal_hair_follicle1.08839609
54MP0005595_abnormal_vascular_smooth1.08715358
55MP0005620_abnormal_muscle_contractility1.06078277
56MP0002063_abnormal_learning/memory/cond1.05976848
57MP0002282_abnormal_trachea_morphology1.05724399
58MP0003942_abnormal_urinary_system1.02768964
59MP0000049_abnormal_middle_ear1.02581102
60MP0003329_amyloid_beta_deposits0.99677964
61MP0005171_absent_coat_pigmentation0.98783680
62MP0000767_abnormal_smooth_muscle0.95482670
63MP0006276_abnormal_autonomic_nervous0.95144492
64MP0009250_abnormal_appendicular_skeleto0.94546393
65MP0003283_abnormal_digestive_organ0.92911151
66MP0010678_abnormal_skin_adnexa0.91829818
67MP0002928_abnormal_bile_duct0.88076262
68MP0002971_abnormal_brown_adipose0.87392097
69MP0002697_abnormal_eye_size0.85641986
70MP0000733_abnormal_muscle_development0.84579067
71MP0004130_abnormal_muscle_cell0.83845719
72MP0003121_genomic_imprinting0.83116483
73MP0002127_abnormal_cardiovascular_syste0.81800582
74MP0008789_abnormal_olfactory_epithelium0.80365614
75MP0000747_muscle_weakness0.79028458
76MP0004087_abnormal_muscle_fiber0.79017120
77MP0005409_darkened_coat_color0.78797476
78MP0002249_abnormal_larynx_morphology0.78592324
79MP0002972_abnormal_cardiac_muscle0.77918705
80MP0006054_spinal_hemorrhage0.77751750
81MP0001486_abnormal_startle_reflex0.77735981
82MP0004811_abnormal_neuron_physiology0.77614857
83MP0003634_abnormal_glial_cell0.76843036
84MP0005220_abnormal_exocrine_pancreas0.75896444
85MP0000566_synostosis0.75859361
86MP0001968_abnormal_touch/_nociception0.75684890
87MP0001529_abnormal_vocalization0.74649622
88MP0000613_abnormal_salivary_gland0.74621077
89MP0005394_taste/olfaction_phenotype0.74433751
90MP0005499_abnormal_olfactory_system0.74433751
91MP0002882_abnormal_neuron_morphology0.74156543
92MP0002272_abnormal_nervous_system0.73958337
93MP0005508_abnormal_skeleton_morphology0.73272912
94MP0005369_muscle_phenotype0.73220065
95MP0008775_abnormal_heart_ventricle0.72932276
96MP0005423_abnormal_somatic_nervous0.72294958
97MP0003937_abnormal_limbs/digits/tail_de0.72059073
98MP0008569_lethality_at_weaning0.71791724
99MP0004036_abnormal_muscle_relaxation0.71500708
100MP0003091_abnormal_cell_migration0.71325553

Predicted human phenotypes

RankGene SetZ-score
1Vertebral arch anomaly (HP:0008438)3.92867878
2Arterial tortuosity (HP:0005116)3.47501549
3Vascular tortuosity (HP:0004948)3.33953018
4Mitral stenosis (HP:0001718)3.23419774
5Papillary thyroid carcinoma (HP:0002895)2.71983902
6Aortic dissection (HP:0002647)2.59427097
7Protrusio acetabuli (HP:0003179)2.57177008
8Pulmonary artery stenosis (HP:0004415)2.56755870
9Limited hip movement (HP:0008800)2.56423293
10Abnormality of the calf musculature (HP:0001430)2.49433497
11Ulnar bowing (HP:0003031)2.41723033
12Neonatal short-limb short stature (HP:0008921)2.41593904
13Soft skin (HP:0000977)2.38974801
14Small epiphyses (HP:0010585)2.37234760
15Atrophic scars (HP:0001075)2.34581581
16Infantile muscular hypotonia (HP:0008947)2.34217403
17Drooling (HP:0002307)2.29255970
18Pulmonic stenosis (HP:0001642)2.24101461
19Split foot (HP:0001839)2.20443594
20Arthropathy (HP:0003040)2.20051972
21Hypoplasia of the iris (HP:0007676)2.18430900
22Cubitus valgus (HP:0002967)2.17597106
23Absent speech (HP:0001344)2.15987365
24Action tremor (HP:0002345)2.14497604
25Pheochromocytoma (HP:0002666)2.12203884
26Cutaneous finger syndactyly (HP:0010554)2.05090950
27Aortic aneurysm (HP:0004942)2.04494733
28Excessive salivation (HP:0003781)2.03675489
29Premature rupture of membranes (HP:0001788)2.02922139
30Morphological abnormality of the middle ear (HP:0008609)2.02807822
31Bladder diverticulum (HP:0000015)2.02247481
32Mitral regurgitation (HP:0001653)2.01026999
33Retinal dysplasia (HP:0007973)2.00229271
34Overgrowth (HP:0001548)1.97402788
35Calf muscle hypertrophy (HP:0008981)1.97334588
36Vertebral clefting (HP:0008428)1.97112164
37Widely spaced teeth (HP:0000687)1.93494896
38Gait imbalance (HP:0002141)1.91221601
39Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91198686
40Turricephaly (HP:0000262)1.90477067
41Aortic regurgitation (HP:0001659)1.90422368
42Tubulointerstitial nephritis (HP:0001970)1.90397930
43Neuroendocrine neoplasm (HP:0100634)1.89891872
44Tibial bowing (HP:0002982)1.88564346
45Neoplasm of the heart (HP:0100544)1.87969670
46Subaortic stenosis (HP:0001682)1.86440111
47Abnormality of the left ventricular outflow tract (HP:0011103)1.86440111
48Hemiparesis (HP:0001269)1.82116349
49Lower limb muscle weakness (HP:0007340)1.81238019
50Spinal rigidity (HP:0003306)1.80481215
51Cutaneous syndactyly (HP:0012725)1.80367526
52Exercise-induced myalgia (HP:0003738)1.78633868
53Abnormality of the lower motor neuron (HP:0002366)1.78482639
54Genital tract atresia (HP:0001827)1.78262794
55Sudden death (HP:0001699)1.76711750
56Vaginal atresia (HP:0000148)1.75198088
57Striae distensae (HP:0001065)1.74643496
58Abnormality of the ischium (HP:0003174)1.73051743
59Polyphagia (HP:0002591)1.72373526
60Megalencephaly (HP:0001355)1.71671722
61Open mouth (HP:0000194)1.69575053
62Hyporeflexia of lower limbs (HP:0002600)1.69399949
63Amyotrophic lateral sclerosis (HP:0007354)1.68905240
64Congenital primary aphakia (HP:0007707)1.68645210
65Flattened epiphyses (HP:0003071)1.68385227
66Muscle hypertrophy of the lower extremities (HP:0008968)1.68289618
67Ankle clonus (HP:0011448)1.66546538
68Atonic seizures (HP:0010819)1.66288718
69Medial flaring of the eyebrow (HP:0010747)1.65876986
70Mitral valve prolapse (HP:0001634)1.65560914
71Subacute progressive viral hepatitis (HP:0006572)1.65241810
72Aplasia involving bones of the upper limbs (HP:0009823)1.64077880
73Aplasia of the phalanges of the hand (HP:0009802)1.64077880
74Aplasia involving bones of the extremities (HP:0009825)1.64077880
75Follicular hyperkeratosis (HP:0007502)1.63507012
76Hypoplastic pelvis (HP:0008839)1.62566050
77Steppage gait (HP:0003376)1.62520923
78Metatarsus adductus (HP:0001840)1.62419191
79Neoplasm of the peripheral nervous system (HP:0100007)1.62414188
80Knee flexion contracture (HP:0006380)1.61102296
81Aortic valve stenosis (HP:0001650)1.60173956
82Absent eyelashes (HP:0000561)1.59019777
83Distal arthrogryposis (HP:0005684)1.58977150
84Large earlobe (HP:0009748)1.58528584
85Wrist flexion contracture (HP:0001239)1.57842304
86Male infertility (HP:0003251)1.57822275
87Increased variability in muscle fiber diameter (HP:0003557)1.57563101
88Decreased lacrimation (HP:0000633)1.57540573
89Exercise-induced muscle cramps (HP:0003710)1.56582494
90Renal dysplasia (HP:0000110)1.56407760
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56314962
92Absent frontal sinuses (HP:0002688)1.56210253
93Chronic hepatic failure (HP:0100626)1.55975222
94Hyperextensible skin (HP:0000974)1.54051286
95Exotropia (HP:0000577)1.53625414
96Alopecia of scalp (HP:0002293)1.52882014
97Abnormality of the right ventricle (HP:0001707)1.50225653
98Round ear (HP:0100830)1.49116089
99Lower limb asymmetry (HP:0100559)1.49045965
100Hip contracture (HP:0003273)1.48173837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.25710736
2MARK13.97439708
3CASK3.78220563
4BCR2.55213500
5EPHB22.35443432
6PDGFRA2.31396907
7AKT32.30658700
8MAP3K41.89373268
9EPHA31.86231191
10ERBB31.84097468
11NTRK21.72407130
12EPHA41.68839413
13OBSCN1.67591096
14CSNK1G21.63529794
15NTRK11.54508520
16FER1.50972718
17MAPK131.48628216
18NTRK31.42666299
19CSNK1A1L1.40749122
20LATS11.38838529
21MAP2K71.33274803
22DMPK1.32460750
23PDGFRB1.28453969
24TNIK1.26387267
25CCNB11.20135513
26CSNK1G31.16079236
27CSNK1G11.14857993
28SGK21.11854328
29NEK91.10907635
30MAPKAPK51.09496514
31PIK3CA1.06013463
32PHKG11.04717064
33PHKG21.04717064
34MAP3K61.03398360
35RIPK11.02060637
36PKN21.01052312
37PRKCE0.97149442
38TRIM280.94647844
39MET0.94616414
40PAK60.94056413
41SGK4940.90179831
42SGK2230.90179831
43DDR20.89417646
44ROCK10.89139815
45MAP4K20.87866373
46CDK50.85298488
47PINK10.83920090
48UHMK10.82877392
49MOS0.75690413
50DYRK20.74652465
51SGK30.74317898
52ROCK20.73858249
53PRKAA10.73559965
54LATS20.72002500
55BMPR1B0.70971902
56MAP2K40.67153794
57DYRK1B0.65995922
58TYRO30.65982393
59CAMK2B0.65980624
60MAP3K20.63362309
61PTK20.62975502
62CAMK2A0.62974282
63MINK10.62531951
64TIE10.62407481
65MAPK70.62371133
66CAMK2D0.62273035
67STK38L0.61757322
68RAF10.61593875
69ERBB40.57935902
70BCKDK0.57021480
71PNCK0.56910588
72LIMK10.56380540
73SIK20.55045054
74WNK30.54127306
75DYRK1A0.53860879
76MAPK100.52502292
77KSR10.52080179
78RET0.51989720
79MAP3K70.50878396
80PAK20.49538323
81RPS6KA20.49238754
82PRKD10.48248615
83PRKACB0.47059667
84PAK30.46908566
85FGFR10.46695840
86YES10.45733201
87PRKCZ0.45527806
88RPS6KB10.44976005
89SRPK10.44968647
90NEK60.44096689
91PKN10.43483316
92PRKG10.43360441
93GSK3A0.42936209
94CAMK2G0.42776118
95PLK20.41196697
96CSNK1D0.40918925
97PRKG20.40869688
98PRKAA20.40115336
99DYRK30.39766256
100CAMK1G0.39440555

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18440323
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04792779
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00706554
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89799577
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88908245
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88895158
7ECM-receptor interaction_Homo sapiens_hsa045121.88224843
8Dilated cardiomyopathy_Homo sapiens_hsa054141.84660408
9Nicotine addiction_Homo sapiens_hsa050331.79314438
10Circadian rhythm_Homo sapiens_hsa047101.63808114
11Axon guidance_Homo sapiens_hsa043601.50500553
12Circadian entrainment_Homo sapiens_hsa047131.49302787
13GABAergic synapse_Homo sapiens_hsa047271.46701707
14Cocaine addiction_Homo sapiens_hsa050301.42354229
15Focal adhesion_Homo sapiens_hsa045101.35971349
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34051956
17Dopaminergic synapse_Homo sapiens_hsa047281.32796974
18Glutamatergic synapse_Homo sapiens_hsa047241.32395457
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31225587
20Steroid biosynthesis_Homo sapiens_hsa001001.28577166
21AMPK signaling pathway_Homo sapiens_hsa041521.26643161
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26117007
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24925342
24Gap junction_Homo sapiens_hsa045401.24528076
25Dorso-ventral axis formation_Homo sapiens_hsa043201.18130217
26Amphetamine addiction_Homo sapiens_hsa050311.17992926
27Phenylalanine metabolism_Homo sapiens_hsa003601.16494217
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12325733
29Long-term depression_Homo sapiens_hsa047301.08471933
30beta-Alanine metabolism_Homo sapiens_hsa004101.06291744
31Hippo signaling pathway_Homo sapiens_hsa043901.05188958
32PPAR signaling pathway_Homo sapiens_hsa033201.04846563
33Fatty acid metabolism_Homo sapiens_hsa012121.04500722
34TGF-beta signaling pathway_Homo sapiens_hsa043501.01351954
35Renin secretion_Homo sapiens_hsa049241.00084752
36Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98396100
37Endometrial cancer_Homo sapiens_hsa052130.98131954
38Protein digestion and absorption_Homo sapiens_hsa049740.97418619
39Propanoate metabolism_Homo sapiens_hsa006400.96974919
40Adherens junction_Homo sapiens_hsa045200.96329617
41Morphine addiction_Homo sapiens_hsa050320.93708015
42Glioma_Homo sapiens_hsa052140.92247319
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92080911
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91814225
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91364454
46Fatty acid biosynthesis_Homo sapiens_hsa000610.89188336
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88779351
48Hedgehog signaling pathway_Homo sapiens_hsa043400.88723535
49Cholinergic synapse_Homo sapiens_hsa047250.88438537
50cAMP signaling pathway_Homo sapiens_hsa040240.87515646
51Gastric acid secretion_Homo sapiens_hsa049710.87466902
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85452033
53Basal cell carcinoma_Homo sapiens_hsa052170.85147509
54Type II diabetes mellitus_Homo sapiens_hsa049300.83907521
55Estrogen signaling pathway_Homo sapiens_hsa049150.83670390
56Melanogenesis_Homo sapiens_hsa049160.81875378
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81606129
58ErbB signaling pathway_Homo sapiens_hsa040120.80373040
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79951995
60MicroRNAs in cancer_Homo sapiens_hsa052060.79437511
61Oxytocin signaling pathway_Homo sapiens_hsa049210.79363993
62Ovarian steroidogenesis_Homo sapiens_hsa049130.78616358
63Insulin signaling pathway_Homo sapiens_hsa049100.78555092
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76544305
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75634263
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74927202
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74899551
68Long-term potentiation_Homo sapiens_hsa047200.74666523
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74047475
70Fatty acid elongation_Homo sapiens_hsa000620.73063803
71Proteoglycans in cancer_Homo sapiens_hsa052050.71973151
72Renal cell carcinoma_Homo sapiens_hsa052110.71747276
73Tight junction_Homo sapiens_hsa045300.71503916
74Insulin secretion_Homo sapiens_hsa049110.71261495
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.70977068
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.69557462
77Vibrio cholerae infection_Homo sapiens_hsa051100.68662916
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68548406
79Rap1 signaling pathway_Homo sapiens_hsa040150.68410891
80Calcium signaling pathway_Homo sapiens_hsa040200.67752313
81Ras signaling pathway_Homo sapiens_hsa040140.67126285
82Synaptic vesicle cycle_Homo sapiens_hsa047210.66435281
83Salivary secretion_Homo sapiens_hsa049700.65534967
84ABC transporters_Homo sapiens_hsa020100.63416538
85Melanoma_Homo sapiens_hsa052180.62302036
86Amoebiasis_Homo sapiens_hsa051460.61842906
87Colorectal cancer_Homo sapiens_hsa052100.60959088
88mTOR signaling pathway_Homo sapiens_hsa041500.60940105
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.57740270
90Butanoate metabolism_Homo sapiens_hsa006500.56558354
91Histidine metabolism_Homo sapiens_hsa003400.56050464
92GnRH signaling pathway_Homo sapiens_hsa049120.54674538
93Prostate cancer_Homo sapiens_hsa052150.53593564
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52748870
95Prolactin signaling pathway_Homo sapiens_hsa049170.50544909
96Glucagon signaling pathway_Homo sapiens_hsa049220.50049857
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49747407
98Bile secretion_Homo sapiens_hsa049760.49650603
99Insulin resistance_Homo sapiens_hsa049310.47837143
100Chronic myeloid leukemia_Homo sapiens_hsa052200.45961437

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