ZNF428

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.73598089
2viral transcription (GO:0019083)5.05683202
3translational termination (GO:0006415)4.72193753
4postsynaptic membrane organization (GO:0001941)4.63797395
5establishment of mitochondrion localization (GO:0051654)4.52710936
6cell migration in hindbrain (GO:0021535)4.48424788
7nucleobase catabolic process (GO:0046113)4.37958627
8behavioral response to nicotine (GO:0035095)4.31173818
9neuron recognition (GO:0008038)4.21136917
10establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.11854440
11mitochondrion transport along microtubule (GO:0047497)4.11854440
12dendritic spine morphogenesis (GO:0060997)3.97489199
13axonal fasciculation (GO:0007413)3.96225851
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96223306
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95079894
16translational elongation (GO:0006414)3.94892557
17neuron cell-cell adhesion (GO:0007158)3.92944204
18sequestering of actin monomers (GO:0042989)3.89840294
19ribosomal small subunit biogenesis (GO:0042274)3.85962469
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83592806
21ATP synthesis coupled proton transport (GO:0015986)3.83592806
22cellular protein complex disassembly (GO:0043624)3.81482048
23adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.80554714
24regulation of synapse structural plasticity (GO:0051823)3.75535004
25transmission of nerve impulse (GO:0019226)3.72057388
26protein localization to synapse (GO:0035418)3.68530098
27cotranslational protein targeting to membrane (GO:0006613)3.68244724
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67295294
29protein targeting to ER (GO:0045047)3.66163702
30viral life cycle (GO:0019058)3.66017875
31auditory behavior (GO:0031223)3.64900714
32substrate-independent telencephalic tangential migration (GO:0021826)3.56010193
33substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.56010193
34positive regulation of synapse assembly (GO:0051965)3.51594677
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48642646
36protein complex disassembly (GO:0043241)3.48112791
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43406693
38protein localization to endoplasmic reticulum (GO:0070972)3.42145983
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.42037933
40ribosomal small subunit assembly (GO:0000028)3.38533129
41chaperone-mediated protein transport (GO:0072321)3.33758534
42axon extension (GO:0048675)3.31411349
43neurofilament cytoskeleton organization (GO:0060052)3.26474453
44macromolecular complex disassembly (GO:0032984)3.25928052
45synaptic vesicle maturation (GO:0016188)3.24256428
46vocalization behavior (GO:0071625)3.23781152
47presynaptic membrane organization (GO:0097090)3.23692703
48synaptic vesicle exocytosis (GO:0016079)3.20678233
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19742728
50presynaptic membrane assembly (GO:0097105)3.19733471
51synaptic transmission, glutamatergic (GO:0035249)3.18869236
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16427937
53response to auditory stimulus (GO:0010996)3.15952415
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.13154833
55regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12657989
56mechanosensory behavior (GO:0007638)3.07937242
57synapse assembly (GO:0007416)3.07137455
58dopamine receptor signaling pathway (GO:0007212)3.07018794
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04968006
60maturation of SSU-rRNA (GO:0030490)3.02485178
61axon ensheathment in central nervous system (GO:0032291)2.98813684
62central nervous system myelination (GO:0022010)2.98813684
63exploration behavior (GO:0035640)2.96717665
64cell-cell junction maintenance (GO:0045217)2.93996284
65negative regulation of microtubule polymerization (GO:0031115)2.93204304
66synaptic transmission, cholinergic (GO:0007271)2.90174285
67retinal ganglion cell axon guidance (GO:0031290)2.89892121
68glutamate secretion (GO:0014047)2.88510395
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88396901
70locomotory exploration behavior (GO:0035641)2.87114988
71respiratory electron transport chain (GO:0022904)2.87004534
72cerebral cortex radially oriented cell migration (GO:0021799)2.84894821
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84302048
74electron transport chain (GO:0022900)2.83954631
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83160899
76neuronal ion channel clustering (GO:0045161)2.81305840
77spinal cord association neuron differentiation (GO:0021527)2.81284794
78neurotransmitter-gated ion channel clustering (GO:0072578)2.80988897
79adult walking behavior (GO:0007628)2.79080645
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78099889
81gamma-aminobutyric acid transport (GO:0015812)2.76077567
82positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75431551
83cell proliferation in forebrain (GO:0021846)2.74131060
84spinal cord development (GO:0021510)2.73959598
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73081772
86regulation of glutamate receptor signaling pathway (GO:1900449)2.70344075
87neuron-neuron synaptic transmission (GO:0007270)2.68876388
88behavioral response to cocaine (GO:0048148)2.68254493
89neuromuscular synaptic transmission (GO:0007274)2.66858949
90short-term memory (GO:0007614)2.66666926
91neuron projection extension (GO:1990138)2.65662223
92axon extension involved in axon guidance (GO:0048846)2.65419895
93neuron projection extension involved in neuron projection guidance (GO:1902284)2.65419895
94negative regulation of axon extension (GO:0030517)2.65334965
95neurotransmitter secretion (GO:0007269)2.64216771
96positive regulation of gastrulation (GO:2000543)2.63452807
97NADH dehydrogenase complex assembly (GO:0010257)2.63137411
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63137411
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.63137411
100protein complex biogenesis (GO:0070271)2.62705747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.25520679
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.79718104
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.30846405
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.01792090
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98725261
6SUZ12_27294783_Chip-Seq_ESCs_Mouse2.67788475
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.67241101
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.66167248
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.65943630
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61971837
11REST_21632747_ChIP-Seq_MESCs_Mouse2.58171338
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.56349755
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51460783
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51460783
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41341282
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39238240
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.37007950
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28004724
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.22966747
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.22103448
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21802634
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.21100256
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04272559
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91953825
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.91177377
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.90667929
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89492653
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.86675797
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86189342
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82610932
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79482415
32DROSHA_22980978_ChIP-Seq_HELA_Human1.78135623
33* CTCF_27219007_Chip-Seq_Bcells_Human1.75780916
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75150303
35RNF2_27304074_Chip-Seq_NSC_Mouse1.70833849
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69704573
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.68895355
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63567595
39OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.61997581
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53635069
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47179948
42SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.47057568
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.46096384
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41398174
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40157999
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36214668
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34833753
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34576228
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.34171225
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.29006073
51LXR_22292898_ChIP-Seq_THP-1_Human1.26947127
52KDM2B_26808549_Chip-Seq_K562_Human1.24113380
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21243410
54P68_20966046_ChIP-Seq_HELA_Human1.20843927
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19629588
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19237982
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13040376
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11342832
59CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10705797
60SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10406598
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09758101
62MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08275593
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08066650
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05417708
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04099501
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.03048447
67THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98608490
68SA1_27219007_Chip-Seq_ERYTHROID_Human0.97742365
69CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95194627
70XRN2_22483619_ChIP-Seq_HELA_Human0.93413299
71TP63_19390658_ChIP-ChIP_HaCaT_Human0.93294237
72OCT4_19829295_ChIP-Seq_ESCs_Human0.93274700
73CTCF_20526341_ChIP-Seq_ESCs_Human0.92829640
74FOXP1_21924763_ChIP-Seq_HESCs_Human0.92322846
75SOX3_22085726_ChIP-Seq_NPCs_Mouse0.91409985
76* ELF1_20517297_ChIP-Seq_JURKAT_Human0.91380257
77SMC4_20622854_ChIP-Seq_HELA_Human0.91257708
78ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91218683
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90323399
80YY1_21170310_ChIP-Seq_MESCs_Mouse0.89229058
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89027443
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88823614
83NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88304584
84* PHF8_20622854_ChIP-Seq_HELA_Human0.88096253
85SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87294677
86BCL6_27268052_Chip-Seq_Bcells_Human0.87071200
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87045497
88SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85792245
89E2F1_20622854_ChIP-Seq_HELA_Human0.85420309
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82006154
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81635133
92ZNF274_21170338_ChIP-Seq_K562_Hela0.80098695
93ERA_21632823_ChIP-Seq_H3396_Human0.79569204
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79560882
95* YY1_22570637_ChIP-Seq_MALME-3M_Human0.78586409
96KLF4_19829295_ChIP-Seq_ESCs_Human0.77991605
97KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77165782
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77150283
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77150283
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76616428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.89596404
2MP0004859_abnormal_synaptic_plasticity3.55518273
3MP0005423_abnormal_somatic_nervous3.14043822
4MP0003880_abnormal_central_pattern3.02698333
5MP0000778_abnormal_nervous_system2.71816613
6MP0003122_maternal_imprinting2.70780500
7MP0003635_abnormal_synaptic_transmissio2.58102456
8MP0002822_catalepsy2.57224032
9MP0002653_abnormal_ependyma_morphology2.49588010
10MP0006276_abnormal_autonomic_nervous2.36637814
11MP0003787_abnormal_imprinting2.25155401
12MP0002063_abnormal_learning/memory/cond2.17813807
13MP0000566_synostosis2.14919157
14MP0002064_seizures2.12093826
15MP0006292_abnormal_olfactory_placode2.11825468
16MP0009745_abnormal_behavioral_response2.08209861
17MP0001529_abnormal_vocalization2.05065383
18MP0002572_abnormal_emotion/affect_behav1.99167939
19MP0002272_abnormal_nervous_system1.95606286
20MP0001905_abnormal_dopamine_level1.91133638
21MP0001968_abnormal_touch/_nociception1.88229890
22MP0003121_genomic_imprinting1.87795634
23MP0004142_abnormal_muscle_tone1.87561160
24MP0003136_yellow_coat_color1.87482494
25MP0000955_abnormal_spinal_cord1.86604438
26MP0002735_abnormal_chemical_nociception1.85511266
27MP0002734_abnormal_mechanical_nocicepti1.81560720
28MP0004742_abnormal_vestibular_system1.80310173
29MP0004270_analgesia1.80290830
30MP0002557_abnormal_social/conspecific_i1.78305645
31MP0004133_heterotaxia1.76626640
32MP0002184_abnormal_innervation1.69035066
33MP0001970_abnormal_pain_threshold1.68998947
34MP0009046_muscle_twitch1.68899411
35MP0002733_abnormal_thermal_nociception1.67897289
36MP0003123_paternal_imprinting1.65264067
37MP0001188_hyperpigmentation1.65037037
38MP0003283_abnormal_digestive_organ1.64737841
39MP0004885_abnormal_endolymph1.60636695
40MP0001486_abnormal_startle_reflex1.60106510
41MP0002882_abnormal_neuron_morphology1.54840408
42MP0005394_taste/olfaction_phenotype1.53147688
43MP0005499_abnormal_olfactory_system1.53147688
44MP0000049_abnormal_middle_ear1.51563288
45MP0004811_abnormal_neuron_physiology1.50126498
46MP0002736_abnormal_nociception_after1.46422558
47MP0008789_abnormal_olfactory_epithelium1.42646559
48MP0002067_abnormal_sensory_capabilities1.41935416
49MP0010030_abnormal_orbit_morphology1.41692791
50MP0001440_abnormal_grooming_behavior1.41330461
51MP0000026_abnormal_inner_ear1.40828352
52MP0000631_abnormal_neuroendocrine_gland1.39644448
53MP0001984_abnormal_olfaction1.38546828
54MP0002152_abnormal_brain_morphology1.32844319
55MP0002752_abnormal_somatic_nervous1.31457340
56MP0002638_abnormal_pupillary_reflex1.28399180
57MP0002909_abnormal_adrenal_gland1.24635123
58MP0003879_abnormal_hair_cell1.21969112
59MP0005645_abnormal_hypothalamus_physiol1.21176904
60MP0001502_abnormal_circadian_rhythm1.19218219
61MP0003938_abnormal_ear_development1.18315387
62MP0002249_abnormal_larynx_morphology1.17115541
63MP0002938_white_spotting1.15312654
64MP0003861_abnormal_nervous_system1.14795772
65MP0002066_abnormal_motor_capabilities/c1.13755270
66MP0008569_lethality_at_weaning1.08688880
67MP0005386_behavior/neurological_phenoty1.08136640
68MP0004924_abnormal_behavior1.08136640
69MP0001963_abnormal_hearing_physiology1.07760133
70MP0003329_amyloid_beta_deposits1.04546247
71MP0001485_abnormal_pinna_reflex1.03235262
72MP0003942_abnormal_urinary_system1.02424025
73MP0002234_abnormal_pharynx_morphology1.01949603
74MP0001986_abnormal_taste_sensitivity1.01843157
75MP0005646_abnormal_pituitary_gland0.99807462
76MP0005551_abnormal_eye_electrophysiolog0.96993867
77MP0005195_abnormal_posterior_eye0.92102118
78MP0003011_delayed_dark_adaptation0.91564627
79MP0003119_abnormal_digestive_system0.88463867
80MP0001293_anophthalmia0.87129104
81MP0004145_abnormal_muscle_electrophysio0.85638312
82MP0002751_abnormal_autonomic_nervous0.83276166
83MP0002928_abnormal_bile_duct0.79152199
84MP0000534_abnormal_ureter_morphology0.78234759
85MP0002102_abnormal_ear_morphology0.77437235
86MP0002069_abnormal_eating/drinking_beha0.77266722
87MP0005084_abnormal_gallbladder_morpholo0.76792959
88MP0009250_abnormal_appendicular_skeleto0.75644415
89MP0003315_abnormal_perineum_morphology0.74681714
90MP0002116_abnormal_craniofacial_bone0.73470716
91MP0009053_abnormal_anal_canal0.73207173
92MP0003631_nervous_system_phenotype0.72013081
93MP0003633_abnormal_nervous_system0.71876169
94MP0002229_neurodegeneration0.71272595
95MP0008877_abnormal_DNA_methylation0.68415238
96MP0003634_abnormal_glial_cell0.68050995
97MP0002081_perinatal_lethality0.66282676
98MP0002837_dystrophic_cardiac_calcinosis0.64577714
99MP0002163_abnormal_gland_morphology0.64548773
100MP0004130_abnormal_muscle_cell0.64283347

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.81703250
2Limb dystonia (HP:0002451)4.90764925
3Abnormality of cells of the erythroid lineage (HP:0012130)4.12181898
4Abnormal number of erythroid precursors (HP:0012131)3.93515747
5Polyphagia (HP:0002591)3.76828303
6Focal motor seizures (HP:0011153)3.44277102
7Reticulocytopenia (HP:0001896)3.25715957
8Agitation (HP:0000713)3.02772002
9Abnormal eating behavior (HP:0100738)2.91709617
10Epileptic encephalopathy (HP:0200134)2.90646780
11Gait imbalance (HP:0002141)2.89437340
12Focal seizures (HP:0007359)2.87461480
13Acute necrotizing encephalopathy (HP:0006965)2.72921659
14Rib fusion (HP:0000902)2.68769233
15Sleep apnea (HP:0010535)2.63209288
16Mitochondrial inheritance (HP:0001427)2.61981887
17Nephronophthisis (HP:0000090)2.58672585
18Abnormal mitochondria in muscle tissue (HP:0008316)2.57904422
19Abnormal respiratory epithelium morphology (HP:0012253)2.45712498
20Abnormal respiratory motile cilium morphology (HP:0005938)2.45712498
21Macrocytic anemia (HP:0001972)2.45341595
22Progressive cerebellar ataxia (HP:0002073)2.43627215
23Poor suck (HP:0002033)2.42929165
24Abnormal ciliary motility (HP:0012262)2.42325569
25Abnormality of midbrain morphology (HP:0002418)2.42158716
26Molar tooth sign on MRI (HP:0002419)2.42158716
27Septo-optic dysplasia (HP:0100842)2.40773050
28Retinal dysplasia (HP:0007973)2.40429632
29Abnormal respiratory motile cilium physiology (HP:0012261)2.36628383
30Lissencephaly (HP:0001339)2.36266665
31Medial flaring of the eyebrow (HP:0010747)2.34328366
32Pachygyria (HP:0001302)2.33826687
33Pancreatic fibrosis (HP:0100732)2.31821550
34Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30820844
35Hypoplasia of the brainstem (HP:0002365)2.30820844
36Type II lissencephaly (HP:0007260)2.30359188
37Failure to thrive in infancy (HP:0001531)2.22478340
38True hermaphroditism (HP:0010459)2.22206894
39Abnormality of the 4th metacarpal (HP:0010012)2.20976405
40Progressive macrocephaly (HP:0004481)2.19011893
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18923111
42Amblyopia (HP:0000646)2.18113983
43Acute encephalopathy (HP:0006846)2.17210870
44Hyperthyroidism (HP:0000836)2.15526946
45Increased hepatocellular lipid droplets (HP:0006565)2.15146059
46Congenital primary aphakia (HP:0007707)2.13600442
47Abnormality of the diencephalon (HP:0010662)2.10783807
48Sclerocornea (HP:0000647)2.10333255
49Drooling (HP:0002307)2.09507664
50Hepatocellular necrosis (HP:0001404)2.07353077
51Nephrogenic diabetes insipidus (HP:0009806)2.04295222
52Lipid accumulation in hepatocytes (HP:0006561)2.03970395
53Anophthalmia (HP:0000528)2.02985151
54Renal Fanconi syndrome (HP:0001994)2.01830741
55Abnormality of the aortic arch (HP:0012303)1.99597670
56Absent/shortened dynein arms (HP:0200106)1.98913459
57Dynein arm defect of respiratory motile cilia (HP:0012255)1.98913459
58Spastic tetraplegia (HP:0002510)1.95707169
59Oligodactyly (hands) (HP:0001180)1.95398720
60Pallor (HP:0000980)1.95198730
61Abnormality of the corticospinal tract (HP:0002492)1.94647465
62Visual hallucinations (HP:0002367)1.94341665
63Turricephaly (HP:0000262)1.94014759
64Febrile seizures (HP:0002373)1.93284462
65Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91946282
66Concave nail (HP:0001598)1.90881555
67Torticollis (HP:0000473)1.90654114
68Partial duplication of thumb phalanx (HP:0009944)1.90323449
69Increased CSF lactate (HP:0002490)1.89857607
70Generalized tonic-clonic seizures (HP:0002069)1.89530742
71Anencephaly (HP:0002323)1.88455695
72Excessive salivation (HP:0003781)1.88315615
73Specific learning disability (HP:0001328)1.87722283
74Maternal diabetes (HP:0009800)1.86581209
75Focal dystonia (HP:0004373)1.86329338
76Pancreatic cysts (HP:0001737)1.85874373
77Esotropia (HP:0000565)1.85666000
78Oligodactyly (HP:0012165)1.84258032
79Abnormality of the labia minora (HP:0012880)1.83298812
80Short 4th metacarpal (HP:0010044)1.83104521
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83104521
82Partial duplication of the phalanx of hand (HP:0009999)1.81100686
83Anomalous pulmonary venous return (HP:0010772)1.80356668
84Broad distal phalanx of finger (HP:0009836)1.80260943
85Ulnar claw (HP:0001178)1.79871628
86Renal dysplasia (HP:0000110)1.76945404
87Hemiparesis (HP:0001269)1.73945014
88Depressed nasal ridge (HP:0000457)1.73584979
89Broad-based gait (HP:0002136)1.72845229
90Myotonia (HP:0002486)1.72479974
91Morphological abnormality of the pyramidal tract (HP:0002062)1.72415278
92Hepatic necrosis (HP:0002605)1.71233401
93Epileptiform EEG discharges (HP:0011182)1.70688416
94Rhinitis (HP:0012384)1.69935820
95Abnormality of the renal medulla (HP:0100957)1.69435922
96Status epilepticus (HP:0002133)1.69393383
97Hypsarrhythmia (HP:0002521)1.68573454
98Down-sloping shoulders (HP:0200021)1.67099796
99Elfin facies (HP:0004428)1.66979430
100Truncus arteriosus (HP:0001660)1.66858645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.20521330
2CASK3.31932655
3NTRK23.22378722
4DYRK23.05400883
5MAPK152.43187106
6MAP2K72.40540790
7EPHB22.37411588
8NTRK32.25689631
9SIK22.16700919
10STK162.11332314
11MAPK132.07646709
12PNCK2.06227384
13TYRO31.89021666
14UHMK11.82553912
15MAP3K111.79432528
16MAP3K41.78581383
17TLK11.77426298
18MINK11.72825296
19PHKG21.48483303
20PHKG11.48483303
21CDK191.48068333
22EPHA41.47322119
23BCKDK1.44033165
24PRKD31.42990193
25DYRK31.39231205
26MAP2K41.39114786
27PRKCG1.38898015
28PKN11.26178251
29PINK11.23090012
30PAK61.22481591
31DYRK1B1.17256794
32VRK21.16190483
33CAMKK11.14437902
34LIMK11.14048469
35NTRK11.12366770
36ARAF1.11338653
37TESK11.10219627
38CSNK1G21.06296962
39PIM21.05217876
40CDK11A1.04062882
41CDK51.01922922
42CDK151.01417931
43WNK30.99922085
44CDK140.99674277
45WNK40.98572090
46MARK20.97872650
47CDK180.91808144
48DYRK1A0.91657195
49RPS6KA20.90498562
50ADRBK20.88705371
51BRAF0.87601533
52CAMK10.84848557
53SGK2230.83479173
54SGK4940.83479173
55NME10.82814460
56STK110.81331189
57ICK0.80869624
58ABL20.79627811
59TESK20.79616693
60CSNK1G30.75849702
61PAK30.73656167
62PRKCZ0.73405471
63CAMK2B0.72051501
64MAPKAPK50.69041367
65AURKA0.68923134
66VRK10.66920949
67MAP3K90.66658247
68TRIB30.65672208
69CAMK2A0.63210801
70DAPK20.59404637
71PRKCH0.56589849
72MAPK120.55293095
73MAP2K20.54332293
74RPS6KA50.53960020
75CAMK2G0.53828277
76TNIK0.53624208
77RPS6KA60.52160471
78MAP4K20.51412199
79DAPK30.50627890
80MAPK40.48884924
81PRKACA0.48492447
82SIK10.48072202
83CSNK1A1L0.48014847
84DDR20.46700901
85RPS6KC10.45522379
86RPS6KL10.45522379
87LRRK20.45382551
88CAMK40.43368528
89CSNK1E0.42085799
90PRKCI0.41220859
91CAMKK20.40715419
92ADRBK10.40309016
93KSR10.34535821
94CDK30.34516396
95SGK10.34395805
96CSNK1G10.32659033
97CSNK1A10.32178452
98GRK70.31763963
99CHEK20.31201391
100GRK50.30617596

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.48082250
2Oxidative phosphorylation_Homo sapiens_hsa001903.94282468
3Nicotine addiction_Homo sapiens_hsa050333.73917385
4Parkinsons disease_Homo sapiens_hsa050123.65815303
5Cardiac muscle contraction_Homo sapiens_hsa042603.42943978
6Alzheimers disease_Homo sapiens_hsa050102.64158676
7Huntingtons disease_Homo sapiens_hsa050162.55527935
8Cocaine addiction_Homo sapiens_hsa050302.46363992
9Synaptic vesicle cycle_Homo sapiens_hsa047212.41385223
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.22595168
11Morphine addiction_Homo sapiens_hsa050322.22538516
12GABAergic synapse_Homo sapiens_hsa047272.17676522
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08797652
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03675827
15Dopaminergic synapse_Homo sapiens_hsa047281.91360207
16Phototransduction_Homo sapiens_hsa047441.90356960
17Glutamatergic synapse_Homo sapiens_hsa047241.87272638
18Axon guidance_Homo sapiens_hsa043601.80551487
19Circadian entrainment_Homo sapiens_hsa047131.80213996
20Sulfur relay system_Homo sapiens_hsa041221.76644456
21Amphetamine addiction_Homo sapiens_hsa050311.64273612
22Cholinergic synapse_Homo sapiens_hsa047251.60287901
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59324082
24Basal cell carcinoma_Homo sapiens_hsa052171.45904654
25Insulin secretion_Homo sapiens_hsa049111.43515384
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30846407
27Hedgehog signaling pathway_Homo sapiens_hsa043401.28796182
28RNA polymerase_Homo sapiens_hsa030201.26692357
29Taste transduction_Homo sapiens_hsa047421.22601926
30Notch signaling pathway_Homo sapiens_hsa043301.22429110
31Collecting duct acid secretion_Homo sapiens_hsa049661.09347343
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09170770
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09075098
34Serotonergic synapse_Homo sapiens_hsa047261.08567687
35Olfactory transduction_Homo sapiens_hsa047401.06163448
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04932100
37Alcoholism_Homo sapiens_hsa050341.04465214
38Oxytocin signaling pathway_Homo sapiens_hsa049211.04010275
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01311661
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00251770
41Gap junction_Homo sapiens_hsa045400.97821180
42Gastric acid secretion_Homo sapiens_hsa049710.95572680
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92752470
44cAMP signaling pathway_Homo sapiens_hsa040240.90796407
45Melanogenesis_Homo sapiens_hsa049160.89205802
46Butanoate metabolism_Homo sapiens_hsa006500.85931866
47Calcium signaling pathway_Homo sapiens_hsa040200.83916969
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83298095
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82855776
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80680469
51Long-term depression_Homo sapiens_hsa047300.73187404
52Salivary secretion_Homo sapiens_hsa049700.72289339
53Hippo signaling pathway_Homo sapiens_hsa043900.69398397
54Dilated cardiomyopathy_Homo sapiens_hsa054140.69305075
55Protein export_Homo sapiens_hsa030600.66936030
56MAPK signaling pathway_Homo sapiens_hsa040100.63781296
57Long-term potentiation_Homo sapiens_hsa047200.62496169
58Prion diseases_Homo sapiens_hsa050200.58866456
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58462637
60Wnt signaling pathway_Homo sapiens_hsa043100.58114951
61Folate biosynthesis_Homo sapiens_hsa007900.55933106
62Renin secretion_Homo sapiens_hsa049240.55611565
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55088241
64ErbB signaling pathway_Homo sapiens_hsa040120.51243605
65Ras signaling pathway_Homo sapiens_hsa040140.50701720
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46900231
67Estrogen signaling pathway_Homo sapiens_hsa049150.46563517
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44830286
69Vibrio cholerae infection_Homo sapiens_hsa051100.44406075
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.44347749
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44196358
72Base excision repair_Homo sapiens_hsa034100.42825002
73Linoleic acid metabolism_Homo sapiens_hsa005910.42667441
74VEGF signaling pathway_Homo sapiens_hsa043700.41432701
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.40981671
76Phenylalanine metabolism_Homo sapiens_hsa003600.39636445
77Tyrosine metabolism_Homo sapiens_hsa003500.39298463
78GnRH signaling pathway_Homo sapiens_hsa049120.39242545
79Pyrimidine metabolism_Homo sapiens_hsa002400.37914654
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36615303
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36584237
82Steroid biosynthesis_Homo sapiens_hsa001000.35443442
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33612314
84Peroxisome_Homo sapiens_hsa041460.33202241
85Purine metabolism_Homo sapiens_hsa002300.32556324
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32225395
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31460449
88Rap1 signaling pathway_Homo sapiens_hsa040150.31438536
89Basal transcription factors_Homo sapiens_hsa030220.31191021
90Type II diabetes mellitus_Homo sapiens_hsa049300.30029477
91Metabolic pathways_Homo sapiens_hsa011000.28563266
92Regulation of autophagy_Homo sapiens_hsa041400.27873320
93Ovarian steroidogenesis_Homo sapiens_hsa049130.27797954
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26743806
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.25925408
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25833935
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.24018607
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21961920
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21728992
100Tryptophan metabolism_Homo sapiens_hsa003800.21645178

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