ZNF414

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfation (GO:0051923)6.15032984
2behavioral response to nicotine (GO:0035095)4.89807670
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.58143343
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.58143343
5NADH dehydrogenase complex assembly (GO:0010257)4.58143343
6DNA deamination (GO:0045006)4.51661608
7cell proliferation in forebrain (GO:0021846)4.46328671
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.05387539
9protein complex biogenesis (GO:0070271)4.04723203
10gamma-aminobutyric acid transport (GO:0015812)4.00210930
11cellular response to ATP (GO:0071318)3.96127385
12water-soluble vitamin biosynthetic process (GO:0042364)3.95876893
13regulation of glomerulus development (GO:0090192)3.90153265
14regulation of germinal center formation (GO:0002634)3.81144732
15somite development (GO:0061053)3.75413772
16mitochondrial respiratory chain complex assembly (GO:0033108)3.63622769
17protein polyglutamylation (GO:0018095)3.58214157
18interferon-gamma secretion (GO:0072643)3.56596987
19DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.54989569
20dentate gyrus development (GO:0021542)3.47726819
21detection of light stimulus involved in sensory perception (GO:0050962)3.46951357
22detection of light stimulus involved in visual perception (GO:0050908)3.46951357
23positive regulation of cAMP-mediated signaling (GO:0043950)3.44235599
24negative regulation of telomere maintenance (GO:0032205)3.42583448
25pharyngeal system development (GO:0060037)3.39559274
26positive regulation of potassium ion transmembrane transport (GO:1901381)3.38737059
27cellular response to exogenous dsRNA (GO:0071360)3.27062268
28membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.22419871
29regulation of mesoderm development (GO:2000380)3.21102007
30DNA damage response, signal transduction resulting in transcription (GO:0042772)3.17369579
31response to xenobiotic stimulus (GO:0009410)3.13993059
32magnesium ion transport (GO:0015693)3.03666631
33positive regulation of defense response to virus by host (GO:0002230)3.03068067
343-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.98354304
35purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.98354304
36transmission of nerve impulse (GO:0019226)2.96899515
37activated T cell proliferation (GO:0050798)2.96320791
38indolalkylamine metabolic process (GO:0006586)2.94773884
39response to pheromone (GO:0019236)2.91161957
40regulation of DNA endoreduplication (GO:0032875)2.88680912
41ovulation cycle (GO:0042698)2.88194056
42membrane repolarization during action potential (GO:0086011)2.87632540
43cellular anion homeostasis (GO:0030002)2.86186940
44preassembly of GPI anchor in ER membrane (GO:0016254)2.85166218
45negative regulation of systemic arterial blood pressure (GO:0003085)2.81140543
46neuronal action potential (GO:0019228)2.80548598
47regulation of cell proliferation involved in kidney development (GO:1901722)2.80506921
48negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78749593
49tryptophan catabolic process (GO:0006569)2.78704787
50indole-containing compound catabolic process (GO:0042436)2.78704787
51indolalkylamine catabolic process (GO:0046218)2.78704787
52positive regulation of synapse maturation (GO:0090129)2.75758872
53regulation of skeletal muscle contraction (GO:0014819)2.73762163
54negative regulation of mast cell activation (GO:0033004)2.72751276
55kynurenine metabolic process (GO:0070189)2.71955196
56positive regulation of triglyceride biosynthetic process (GO:0010867)2.69484397
57epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.67251929
58parturition (GO:0007567)2.67233369
59positive regulation of fatty acid oxidation (GO:0046321)2.65446176
60positive regulation of glomerulus development (GO:0090193)2.65430036
61primary amino compound metabolic process (GO:1901160)2.63871777
62cornea development in camera-type eye (GO:0061303)2.63576290
63positive regulation of fatty acid transport (GO:2000193)2.62702880
64serotonin metabolic process (GO:0042428)2.61940342
65L-fucose metabolic process (GO:0042354)2.60384963
66L-fucose catabolic process (GO:0042355)2.60384963
67fucose catabolic process (GO:0019317)2.60384963
68adaptation of signaling pathway (GO:0023058)2.60243677
69regulation of collateral sprouting (GO:0048670)2.57040523
70indole-containing compound metabolic process (GO:0042430)2.56572602
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56297480
72endoderm formation (GO:0001706)2.54931953
73regulation of female receptivity (GO:0045924)2.54384823
74regulation of synapse maturation (GO:0090128)2.53645471
75otic vesicle formation (GO:0030916)2.53410186
76membrane depolarization during action potential (GO:0086010)2.51652836
77lung morphogenesis (GO:0060425)2.51262634
78positive regulation of T cell apoptotic process (GO:0070234)2.49942756
79positive regulation of cardiac muscle cell differentiation (GO:2000727)2.49598832
80ATP synthesis coupled proton transport (GO:0015986)2.48724525
81energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48724525
82negative regulation of astrocyte differentiation (GO:0048712)2.47550139
83reflex (GO:0060004)2.47350105
84negative regulation of response to food (GO:0032096)2.47277677
85negative regulation of appetite (GO:0032099)2.47277677
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47269257
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47269257
88regulation of action potential (GO:0098900)2.47116490
89negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.46306840
90regulation of phospholipid biosynthetic process (GO:0071071)2.46169452
91negative regulation of T cell differentiation in thymus (GO:0033085)2.45691410
92regulation of membrane repolarization (GO:0060306)2.45061192
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37239250
94regulation of transcription regulatory region DNA binding (GO:2000677)2.36783997
95DNA methylation involved in gamete generation (GO:0043046)2.35850635
96positive regulation of icosanoid secretion (GO:0032305)2.35705728
97retinal ganglion cell axon guidance (GO:0031290)2.35176121
98regulation of rhodopsin mediated signaling pathway (GO:0022400)2.35108061
99spinal cord development (GO:0021510)2.34689206
100GPI anchor metabolic process (GO:0006505)2.33907941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44680207
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.35778562
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.96755662
4ZNF274_21170338_ChIP-Seq_K562_Hela2.73981474
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.58583943
6GBX2_23144817_ChIP-Seq_PC3_Human2.40874971
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40537110
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39086594
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34711157
10VDR_22108803_ChIP-Seq_LS180_Human2.32714257
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.19667090
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12693117
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08959886
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.08823002
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04344025
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97204253
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91891556
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89931933
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84659732
20EWS_26573619_Chip-Seq_HEK293_Human1.82494815
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.78660799
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77254465
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71271997
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71117735
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67660459
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67020021
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66560708
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66020866
29REST_21632747_ChIP-Seq_MESCs_Mouse1.63880275
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60501745
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60501745
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.57620496
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.57493311
34IRF1_19129219_ChIP-ChIP_H3396_Human1.56480997
35RNF2_27304074_Chip-Seq_NSC_Mouse1.53293449
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53068759
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52918814
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51248973
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46199013
40IGF1R_20145208_ChIP-Seq_DFB_Human1.45149867
41* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42870418
42FUS_26573619_Chip-Seq_HEK293_Human1.40959136
43P300_19829295_ChIP-Seq_ESCs_Human1.39909097
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.39555798
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39021712
46MYC_18940864_ChIP-ChIP_HL60_Human1.37812854
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32568553
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30367303
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28576043
50BCAT_22108803_ChIP-Seq_LS180_Human1.27243013
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26737057
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24415145
53ER_23166858_ChIP-Seq_MCF-7_Human1.24373351
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22276975
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21498469
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18097277
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.17448272
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.17311841
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.15890175
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15712343
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15256848
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11025872
63NCOR_22424771_ChIP-Seq_293T_Human1.10924060
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.10593577
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.10036412
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09865459
67TP53_22573176_ChIP-Seq_HFKS_Human1.09299050
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05846873
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.05767727
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04161703
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.04161703
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03377377
73ERA_21632823_ChIP-Seq_H3396_Human1.02840050
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02463525
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02463525
76DROSHA_22980978_ChIP-Seq_HELA_Human1.02109152
77TAF15_26573619_Chip-Seq_HEK293_Human1.01323464
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01306004
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00851493
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00653862
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.00537558
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00457934
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98059057
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97618125
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.95972490
86P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95148587
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94401244
88NANOG_20526341_ChIP-Seq_ESCs_Human0.93319094
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92955348
90TAF2_19829295_ChIP-Seq_ESCs_Human0.92114979
91TCF4_23295773_ChIP-Seq_U87_Human0.92037091
92STAT3_23295773_ChIP-Seq_U87_Human0.91432706
93NANOG_19829295_ChIP-Seq_ESCs_Human0.91263450
94SOX2_19829295_ChIP-Seq_ESCs_Human0.91263450
95CBP_20019798_ChIP-Seq_JUKART_Human0.90073675
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90073675
97AR_25329375_ChIP-Seq_VCAP_Human0.89107786
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88876633
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.88135213
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87373616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland2.99626466
2MP0006292_abnormal_olfactory_placode2.80883022
3MP0004885_abnormal_endolymph2.72099118
4MP0002160_abnormal_reproductive_system2.65765479
5MP0001968_abnormal_touch/_nociception2.38356461
6MP0002138_abnormal_hepatobiliary_system2.35749912
7MP0005389_reproductive_system_phenotype2.23976681
8MP0002837_dystrophic_cardiac_calcinosis2.23535746
9MP0000049_abnormal_middle_ear2.19359501
10MP0003646_muscle_fatigue2.17432218
11MP0008877_abnormal_DNA_methylation2.09166933
12MP0004142_abnormal_muscle_tone2.05258516
13MP0000631_abnormal_neuroendocrine_gland2.04219180
14MP0002272_abnormal_nervous_system1.99483753
15MP0002653_abnormal_ependyma_morphology1.99457471
16MP0002102_abnormal_ear_morphology1.92614396
17MP0006072_abnormal_retinal_apoptosis1.91517445
18MP0008872_abnormal_physiological_respon1.85764063
19MP0002736_abnormal_nociception_after1.84371924
20MP0004145_abnormal_muscle_electrophysio1.82005005
21MP0005551_abnormal_eye_electrophysiolog1.81849172
22MP0009745_abnormal_behavioral_response1.77057470
23MP0001485_abnormal_pinna_reflex1.75603631
24MP0002163_abnormal_gland_morphology1.75502561
25MP0004133_heterotaxia1.69485397
26MP0005645_abnormal_hypothalamus_physiol1.67852624
27MP0003011_delayed_dark_adaptation1.63433842
28MP0002735_abnormal_chemical_nociception1.62845372
29MP0001440_abnormal_grooming_behavior1.56189618
30MP0005671_abnormal_response_to1.52160059
31MP0004134_abnormal_chest_morphology1.45825731
32MP0002064_seizures1.45188330
33MP0002733_abnormal_thermal_nociception1.44692562
34MP0005379_endocrine/exocrine_gland_phen1.41056870
35MP0000678_abnormal_parathyroid_gland1.40382360
36MP0001919_abnormal_reproductive_system1.37301548
37MP0002277_abnormal_respiratory_mucosa1.37069270
38MP0001970_abnormal_pain_threshold1.35627340
39MP0003635_abnormal_synaptic_transmissio1.34935082
40MP0004742_abnormal_vestibular_system1.34692869
41MP0001502_abnormal_circadian_rhythm1.32317379
42MP0001905_abnormal_dopamine_level1.31686931
43MP0002876_abnormal_thyroid_physiology1.30625015
44MP0009046_muscle_twitch1.27959347
45MP0009250_abnormal_appendicular_skeleto1.26868251
46MP0000026_abnormal_inner_ear1.24449893
47MP0002572_abnormal_emotion/affect_behav1.23175370
48MP0005253_abnormal_eye_physiology1.22151511
49MP0005084_abnormal_gallbladder_morpholo1.21738744
50MP0001486_abnormal_startle_reflex1.21655975
51MP0003283_abnormal_digestive_organ1.19414322
52MP0003195_calcinosis1.17893058
53MP0003880_abnormal_central_pattern1.16039471
54MP0002557_abnormal_social/conspecific_i1.15151861
55MP0003938_abnormal_ear_development1.14656162
56MP0002938_white_spotting1.12554536
57MP0006276_abnormal_autonomic_nervous1.12244436
58MP0002928_abnormal_bile_duct1.11766032
59MP0001963_abnormal_hearing_physiology1.10322695
60MP0003567_abnormal_fetal_cardiomyocyte1.08205690
61MP0002063_abnormal_learning/memory/cond1.06952338
62MP0002734_abnormal_mechanical_nocicepti1.06422794
63MP0004130_abnormal_muscle_cell1.03695653
64MP0003119_abnormal_digestive_system1.01500222
65MP0000685_abnormal_immune_system1.00862046
66MP0003787_abnormal_imprinting0.98934190
67MP0001348_abnormal_lacrimal_gland0.94245128
68MP0001986_abnormal_taste_sensitivity0.93216543
69MP0005174_abnormal_tail_pigmentation0.92986802
70MP0009379_abnormal_foot_pigmentation0.92953630
71MP0000372_irregular_coat_pigmentation0.91130582
72MP0002234_abnormal_pharynx_morphology0.90936889
73MP0002752_abnormal_somatic_nervous0.90875285
74MP0000613_abnormal_salivary_gland0.88812294
75MP0003879_abnormal_hair_cell0.88462903
76MP0005195_abnormal_posterior_eye0.88364639
77MP0002067_abnormal_sensory_capabilities0.86936634
78MP0003724_increased_susceptibility_to0.86476396
79MP0002184_abnormal_innervation0.85714575
80MP0009053_abnormal_anal_canal0.84888399
81MP0008875_abnormal_xenobiotic_pharmacok0.83413636
82MP0000569_abnormal_digit_pigmentation0.83348722
83MP0001501_abnormal_sleep_pattern0.79753682
84MP0004859_abnormal_synaptic_plasticity0.79225437
85MP0002932_abnormal_joint_morphology0.78041307
86MP0002249_abnormal_larynx_morphology0.77413601
87MP0001529_abnormal_vocalization0.76685888
88MP0008789_abnormal_olfactory_epithelium0.75724227
89MP0001764_abnormal_homeostasis0.74276408
90MP0000230_abnormal_systemic_arterial0.74024323
91MP0001188_hyperpigmentation0.73416482
92MP0009765_abnormal_xenobiotic_induced0.73333124
93MP0003638_abnormal_response/metabolism_0.73083733
94MP0003937_abnormal_limbs/digits/tail_de0.72324474
95MP0001873_stomach_inflammation0.72081892
96MP0004147_increased_porphyrin_level0.68300875
97MP0005410_abnormal_fertilization0.66539495
98MP0004924_abnormal_behavior0.65918810
99MP0005386_behavior/neurological_phenoty0.65918810
100MP0001765_abnormal_ion_homeostasis0.65820284

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.80530637
2Pendular nystagmus (HP:0012043)3.74381899
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.69030164
4Abolished electroretinogram (ERG) (HP:0000550)3.64048274
5Conjunctival hamartoma (HP:0100780)3.57392015
6Pancreatic fibrosis (HP:0100732)3.53522407
7Congenital stationary night blindness (HP:0007642)3.47729369
8True hermaphroditism (HP:0010459)3.47282618
9Abnormality of the proximal phalanges of the hand (HP:0009834)3.39309044
10Genetic anticipation (HP:0003743)3.37658248
11Molar tooth sign on MRI (HP:0002419)3.18885160
12Abnormality of midbrain morphology (HP:0002418)3.18885160
13Abnormal rod and cone electroretinograms (HP:0008323)3.15986551
14Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.09933907
15Progressive cerebellar ataxia (HP:0002073)3.07050702
16Abnormality of the middle phalanges of the toes (HP:0010183)2.97284190
17Asplenia (HP:0001746)2.96544359
18Nephronophthisis (HP:0000090)2.95221254
19Decreased central vision (HP:0007663)2.93016459
20Abnormality of the phalanges of the 2nd finger (HP:0009541)2.87539935
21Abnormality of the phalanges of the 5th finger (HP:0004213)2.85667073
22Aplasia/Hypoplasia of the spleen (HP:0010451)2.85049810
23Increased corneal curvature (HP:0100692)2.84730735
24Keratoconus (HP:0000563)2.84730735
25Hamartoma of the eye (HP:0010568)2.84339573
26Hypoplasia of the uterus (HP:0000013)2.82518183
27Furrowed tongue (HP:0000221)2.73084369
28Abnormal number of erythroid precursors (HP:0012131)2.66490287
29Abnormality of DNA repair (HP:0003254)2.63611440
30Short 1st metacarpal (HP:0010034)2.59769869
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.59769869
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59196341
33Aplasia/hypoplasia of the uterus (HP:0008684)2.51528146
34Severe visual impairment (HP:0001141)2.46753295
35Symphalangism affecting the phalanges of the hand (HP:0009773)2.46444994
36Attenuation of retinal blood vessels (HP:0007843)2.46121740
37Short femoral neck (HP:0100864)2.41442855
38Short hallux (HP:0010109)2.40100182
39Methylmalonic acidemia (HP:0002912)2.39673756
40Cystic liver disease (HP:0006706)2.37978098
41Abnormality of the renal medulla (HP:0100957)2.34597964
42Abnormality of cells of the erythroid lineage (HP:0012130)2.31713253
43Abnormality of the renal cortex (HP:0011035)2.28463928
44Type II lissencephaly (HP:0007260)2.27798181
45Mitochondrial inheritance (HP:0001427)2.27760622
46Congenital sensorineural hearing impairment (HP:0008527)2.26973063
47Aplasia/Hypoplasia of the hallux (HP:0008362)2.26282289
48Congenital, generalized hypertrichosis (HP:0004540)2.24964745
49Abnormality of the 1st metacarpal (HP:0010009)2.24458612
50Sclerocornea (HP:0000647)2.22905154
51Morphological abnormality of the middle ear (HP:0008609)2.21782745
52Gaze-evoked nystagmus (HP:0000640)2.20776169
533-Methylglutaconic aciduria (HP:0003535)2.20675149
54Agitation (HP:0000713)2.20022905
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.19049080
56Bone cyst (HP:0012062)2.14230762
57Male pseudohermaphroditism (HP:0000037)2.14136768
58Short tibia (HP:0005736)2.13114365
59Abnormality of the nasal septum (HP:0000419)2.13072944
60Bony spicule pigmentary retinopathy (HP:0007737)2.12426661
61Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.12069589
62Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.11789202
63Aplasia/Hypoplasia of the patella (HP:0006498)2.08387217
64Meningioma (HP:0002858)2.08126209
65Hepatocellular necrosis (HP:0001404)2.04833291
66Septo-optic dysplasia (HP:0100842)2.03564541
67Chronic hepatic failure (HP:0100626)2.02368640
68Fibular aplasia (HP:0002990)2.02318786
69Methylmalonic aciduria (HP:0012120)2.02000100
70Hypoplastic pelvis (HP:0008839)2.01696237
71Anomalous pulmonary venous return (HP:0010772)1.99759951
72Goiter (HP:0000853)1.98928345
73Chorioretinal atrophy (HP:0000533)1.98491479
74Dynein arm defect of respiratory motile cilia (HP:0012255)1.98463497
75Absent/shortened dynein arms (HP:0200106)1.98463497
76Acute necrotizing encephalopathy (HP:0006965)1.97256528
77Mesomelia (HP:0003027)1.96482688
78Increased CSF lactate (HP:0002490)1.95921988
79Adactyly (HP:0009776)1.94485920
80Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.92510993
81Abnormality of the renal collecting system (HP:0004742)1.89206877
82Concave nail (HP:0001598)1.87961127
83Small hand (HP:0200055)1.87498764
84Medial flaring of the eyebrow (HP:0010747)1.87126970
85Synostosis of carpal bones (HP:0005048)1.86702615
86Hypoplasia of the ulna (HP:0003022)1.81056423
87Anencephaly (HP:0002323)1.80541737
88Clumsiness (HP:0002312)1.80203512
89IgG deficiency (HP:0004315)1.79218702
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78987244
91Short 4th metacarpal (HP:0010044)1.78987244
92Tubular atrophy (HP:0000092)1.78603265
93Abnormal drinking behavior (HP:0030082)1.78393793
94Polydipsia (HP:0001959)1.78393793
95Prostate neoplasm (HP:0100787)1.78054981
96Visual hallucinations (HP:0002367)1.76731619
97Adrenal hypoplasia (HP:0000835)1.76721075
98Abnormality of the 4th metacarpal (HP:0010012)1.76279188
99Megalencephaly (HP:0001355)1.74410151
100Aplasia/Hypoplasia of the fibula (HP:0006492)1.74142229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.68109562
2FRK3.59851486
3GRK13.30771032
4TAOK32.78078378
5VRK22.69355007
6NUAK12.48196748
7TAF12.45977234
8PINK12.35438879
9MAP4K22.28830149
10BCKDK2.24673253
11TXK2.21433311
12TLK12.15475781
13BMPR1B1.86064347
14ZAK1.77630493
15PRKD21.64019310
16WNK31.60125353
17IKBKB1.53326685
18GRK71.53086787
19DYRK21.51505015
20MAPK131.49112627
21WNK41.47513440
22VRK11.37115296
23GRK51.36756656
24INSRR1.31720799
25NME21.31245418
26TNIK1.26559653
27ADRBK11.26215983
28DAPK21.25168410
29CSNK1G21.24559140
30RPS6KA61.18653108
31CSNK1G31.15945646
32MAPKAPK31.11717458
33CASK1.08183350
34TIE11.04886766
35MAPKAPK51.03198863
36PRKCG0.99249189
37CSNK1G10.95666253
38GRK60.93420548
39CSNK1A1L0.93085299
40SGK20.90925379
41KIT0.90440505
42STK160.90131755
43PLK20.89378301
44PAK30.89058996
45DYRK30.88660858
46TEC0.88614825
47PKN10.88364704
48MAP4K10.87310956
49MAP3K40.86485893
50RPS6KC10.86148697
51RPS6KL10.86148697
52MAP2K60.81760685
53ACVR1B0.81431617
54PRKCE0.80073446
55ABL20.79082844
56MAP2K70.78836015
57NTRK20.77221438
58SIK20.74769483
59TNK20.74321189
60SGK4940.74086096
61SGK2230.74086096
62MAPK150.72658139
63PHKG20.72322527
64PHKG10.72322527
65HIPK20.70931984
66CSNK1A10.68422224
67SYK0.68300480
68PRKACA0.67451592
69PRKCQ0.66730991
70RPS6KA20.66478586
71PTK2B0.63231955
72MAP2K20.62328411
73STK110.62014284
74CDK190.61564323
75AURKA0.60914479
76CAMK2A0.60282669
77MARK10.56814118
78PRKCH0.56802935
79NEK90.56681366
80FLT30.56245235
81OXSR10.55738464
82CAMKK20.55508934
83RPS6KA50.52638150
84LYN0.52370376
85PRKCI0.51640504
86MUSK0.50664249
87IKBKE0.50417374
88ITK0.47194058
89NTRK30.46893129
90PRKCA0.46671756
91SGK30.46610013
92CAMK10.46542208
93MATK0.45147275
94CAMK2B0.43874155
95PRKAA10.41956025
96DAPK30.41282649
97CDK90.40330166
98PIM20.39485498
99DAPK10.39383940
100ERBB20.38457197

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.86459984
2Oxidative phosphorylation_Homo sapiens_hsa001902.62200427
3Phototransduction_Homo sapiens_hsa047442.57756466
4Nicotine addiction_Homo sapiens_hsa050332.51801672
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.50100692
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20854070
7Sulfur metabolism_Homo sapiens_hsa009202.18638814
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.17390461
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00443391
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94703718
11Parkinsons disease_Homo sapiens_hsa050121.94619085
12Linoleic acid metabolism_Homo sapiens_hsa005911.82753096
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81685677
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78891328
15Morphine addiction_Homo sapiens_hsa050321.78613534
16Homologous recombination_Homo sapiens_hsa034401.72310830
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68917162
18Nitrogen metabolism_Homo sapiens_hsa009101.64653627
19Ribosome_Homo sapiens_hsa030101.64031464
20Sulfur relay system_Homo sapiens_hsa041221.60637537
21Primary immunodeficiency_Homo sapiens_hsa053401.53821274
22Alzheimers disease_Homo sapiens_hsa050101.44839482
23Cardiac muscle contraction_Homo sapiens_hsa042601.42696200
24Chemical carcinogenesis_Homo sapiens_hsa052041.41357112
25RNA polymerase_Homo sapiens_hsa030201.36205727
26Olfactory transduction_Homo sapiens_hsa047401.35891574
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35439739
28Selenocompound metabolism_Homo sapiens_hsa004501.33058393
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32015440
30Asthma_Homo sapiens_hsa053101.28351231
31Taste transduction_Homo sapiens_hsa047421.28271141
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26687053
33Retinol metabolism_Homo sapiens_hsa008301.26601231
34Insulin secretion_Homo sapiens_hsa049111.24283769
35Ether lipid metabolism_Homo sapiens_hsa005651.23862581
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23686671
37Protein export_Homo sapiens_hsa030601.20008347
38Huntingtons disease_Homo sapiens_hsa050161.18398988
39Tryptophan metabolism_Homo sapiens_hsa003801.17001586
40Circadian entrainment_Homo sapiens_hsa047131.16964705
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.16824387
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16034263
43Basal transcription factors_Homo sapiens_hsa030221.12905309
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11758674
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10549678
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07611431
47GABAergic synapse_Homo sapiens_hsa047271.06287474
48Glutamatergic synapse_Homo sapiens_hsa047241.01735300
49Serotonergic synapse_Homo sapiens_hsa047261.01332853
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98383792
51Glycerolipid metabolism_Homo sapiens_hsa005610.96262217
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95534789
53Fanconi anemia pathway_Homo sapiens_hsa034600.94460484
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94245653
55Butanoate metabolism_Homo sapiens_hsa006500.91637445
56Collecting duct acid secretion_Homo sapiens_hsa049660.90982605
57Arachidonic acid metabolism_Homo sapiens_hsa005900.85861735
58Hedgehog signaling pathway_Homo sapiens_hsa043400.83493739
59Calcium signaling pathway_Homo sapiens_hsa040200.83004683
60Caffeine metabolism_Homo sapiens_hsa002320.80800313
61Dorso-ventral axis formation_Homo sapiens_hsa043200.78060630
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76895123
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75433362
64Cholinergic synapse_Homo sapiens_hsa047250.75109816
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74992994
66Vitamin digestion and absorption_Homo sapiens_hsa049770.73823978
67Salivary secretion_Homo sapiens_hsa049700.71939061
68Gastric acid secretion_Homo sapiens_hsa049710.71627732
69RNA degradation_Homo sapiens_hsa030180.70526027
70Melanoma_Homo sapiens_hsa052180.69506519
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68736046
72Basal cell carcinoma_Homo sapiens_hsa052170.67972014
73One carbon pool by folate_Homo sapiens_hsa006700.67144594
74Peroxisome_Homo sapiens_hsa041460.66581291
75Rheumatoid arthritis_Homo sapiens_hsa053230.63433460
76Renin secretion_Homo sapiens_hsa049240.63189599
77Regulation of autophagy_Homo sapiens_hsa041400.63030984
78Type I diabetes mellitus_Homo sapiens_hsa049400.62941703
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62663610
80Allograft rejection_Homo sapiens_hsa053300.59131332
81Ovarian steroidogenesis_Homo sapiens_hsa049130.58399883
82Dopaminergic synapse_Homo sapiens_hsa047280.56828635
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55486316
84Systemic lupus erythematosus_Homo sapiens_hsa053220.55079574
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54645973
86Cocaine addiction_Homo sapiens_hsa050300.53494371
87Graft-versus-host disease_Homo sapiens_hsa053320.52989004
88Autoimmune thyroid disease_Homo sapiens_hsa053200.51674780
89Oxytocin signaling pathway_Homo sapiens_hsa049210.51316827
90Synaptic vesicle cycle_Homo sapiens_hsa047210.50890418
91MAPK signaling pathway_Homo sapiens_hsa040100.47426221
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46173765
93Nucleotide excision repair_Homo sapiens_hsa034200.43854322
94Hematopoietic cell lineage_Homo sapiens_hsa046400.43474382
95cAMP signaling pathway_Homo sapiens_hsa040240.42438875
96ABC transporters_Homo sapiens_hsa020100.42382994
97Fat digestion and absorption_Homo sapiens_hsa049750.42013145
98Metabolic pathways_Homo sapiens_hsa011000.41755552
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.39957810
100Amphetamine addiction_Homo sapiens_hsa050310.39125091

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